Professional Documents
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2013 Annual Report
2013 Annual Report
tartup Technology Transfer Consulting Licensing Patent Protection Material Transfer Intellectual P
Cover: In 2006, Doctors Dmitry Oleynikov and Shane Farritor developed mini surgical robots that decrease the
size of surgical incisions. The robotic surgical device enters a patients body using a single incision, which should
be much less invasive than traditional surgery
meaning shorter recovery time for patients and reduced-cost
hospital stays. The patented technology is licensed to Virtual Incision (see page 7), a startup company that has
attracted more than $3 million in private investments so far.
(Photo: University of Nebraska-Lincoln Office of Research)
Contents
Watch the UNeMed video here:
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UNeMed
From bench to bedside
UNeMed serves the faculty, staff,
and students at the University of Nebraska Medical Center and helps
them identify problems and develop solutions that promote the general health and welfare of the state.
Whether those solutions are new
drug candidates, medical devices, or
methods for treating diseases, all innovations are evaluated for their scientific and commercial potential by
UNeMeds experienced group of staff,
postdocs and interns.
UNMC employees first disclose
their innovative solutions to UNeMed,
which then works to identify and
MISSION
In the beginning
In 1991 the Board of Regents of the University of Nebraska saw that innovation and discovery needed help
going beyond academic journals and into the hands of
people who could benefit most.
In a move to protect and commercialize world-class
intellectual property created at the University of Nebraska Medical Center, the Regents established UNeMed
Corporation as the licensing arm for UNMC technology.
As a for-profit corporation, UNeMed also administered
other commercial and research contracts for UNMC. The
VALUES
VISION
job of evaluating
and managing
new inventions
fell to the Intellectual Property Office.
UNeMed eventually absorbed the Intellectual Property Office in a 2007 restructuring. The restructuring folded
UNeMed into UNMCs research division under the Vice
Chancellor for Research, creating UNeMed as it exists
today a world-leading technology transfer office that
springboards Nebraska innovation from the research
bench to patients bedsides.
The mission today goes far beyond the modest beginnings 22 years ago.
UNeMed has since established itself as a national
leader among technology transfer offices, reaching far
above and beyond the traditional role of licensing technologies and filing patent applications.
UNeMeds progressive approach is infused with an entrepreneurial spirit that places the office at center stage as
a major player in the startup, consulting, and conferencing
communities.
Playing that role is made easier with a partner like
UNMC, which has undergone a transformative period of
growth that has firmly placed a large star over Omaha on
the biomedical research map.
Facilities
UNMC Rendering
UNMC Rendering
With construction set to begin in early 2014, the new College of Pharmacy building will house laboratory and research
support space with an emphasis on infectious diseases and
dedicated to three key areas: drug discovery and development, drug delivery, and clinical and translational research.
Completion of the $35 million construction project is expected in 2015.
RESEARCH CENTERS
n Center for Advanced Surgical
Technology
n Center for Biopreparedness
Education
n Center for Clinical and
Translational Research
n Center for Collaboration on
Research Design and Analysis
n Center for Drug Delivery and
Nanomedicine
n Center for Environmental Health
and Toxicology
n Center for Health Services
Research
n Center for Humanities, Ethics and
Society
n Center for Neurodegenerative
Disorders
n Center for Research in Leukemia
and Lymphoma
n Eppley Cancer Center
n Center for Integrative and
Translational Neuroscience
n Nebraska Center for Cellular
Signaling
n Center for Staphylococcal
Research
MAJOR PROGRAMS
n Gastrointestinal Cancer (SPORE)
n Mass Spectrometry in Clinical
Diagnosis of Nerve Agent
Exposure
n The Molecular Biology of
Neurosensory Systems (COBRE)
n Nebraska Center for Cellular
Signaling
n Nebraska Center for
Nanomedicine
n Nebraska Research Network in
Functional Genomics (INBRE)
n Nebraska Regenerative Medicine
Project
n Neural Immunity in HIV Dementia
n Proteomic Strategies for AIDS and
Drug Abuse - HIV and METH
CNS Synergy
n Staphylococcal Biofilm and
Disease
n Chronic HIV Infection and Aging in
NeuroAIDS (CHAIN) Center
People
UNeMed Staff
Michael Dixon
President & CEO
Joe Runge
Director of Business Development
Cori Harsh
Finance Manager
BOARD OF DIRECTORS
Donald Leuenberger
Chair
Vice Chancellor for Business and
Finance
University of Nebraska Medical
Center
Michael Dixon, Ph.D.
President & Chief Executive Officer
UNeMed Corporation
Richard Spellman, Esq.
General Counsel for Healthcare
University of Nebraska Medical
Center
Mike Pallesen
Board Secretary and General
Counsel
Cline Williams, Wright, Johnson &
Oldfather
Steve Schreiner
Vice President & Director of
Licensing and Marketing
Matthew Boehm
Senior Licensing Specialist
Jason T. Nickla
Vice President & Director of
Intellectual Property
Jack Mayfield
Contracts Manager
Valerie Gunderson
Office Manager
Mindy Ware
Patent Associate
Charlie Litton
Communications Associate
Joined UNeMed: 2013
Qian Zhang
Licensing Associate
Caronda Moore
Licensing Associate
Deepak Madhaven
Physician in Residence
Gary L. Madsen
Entrepreneur in Residence
Agnes Lenagh
Licensing Associate
Anne Rivas
Office Associate
Jack A. Hartwigsen
Senior Licensing Consultant
Activities
Featured startups built in FY 2013
Radux Devices, LLC
Startups
Many inventions disclosed to UNeMed are at an
extremely early stage of development, and often industry
partners require additional
research data before entering into formal relationships.
In such a circumstance, new
corporate entities are often
the most appropriate avenue
for product development.
UNeMed works with
entrepreneurs, investors and
consultants to form new companies around disclosed technologies. UNeMed nurtures
these companies identifying
early investors, grant opportunities and potential leaders
while often taking an equity
stake in the business.
In fiscal year 2013, UNeMed helped establish four
new startup companies, including Bohe Biotech, a new
company in China that plans
to develop a UNMC technology that could make things
like mouthwash and toothpaste provide fresh breath all
day long.
Other companies formed
in 2013 are Radux Devices,
LLC, ProTransit Nanotherapy,
LLC, and Trak Surgical, Inc.
(See related story.)
ProTransit
Nanotherapy, LLC
Gary Madsen (left) and UNeMed president Michael Dixon sign on June 12, 2013,
the licensing agreement that made ProTransit Nanotherapy, LLC a reality. ProTransit
will use technology developed at UNMC to make things like sunscreen more effective barriers against skin cancer.
UNeMeds
entrepreneur
in residence, Gary Madsen,
Ph.D., built ProTransit Nanotherapy, LLC, on a drug delivery nanoparticle developed at the University
of Nebraska Medical Center. ProTransit Nanotherapy will begin operations by perfecting
a targeted system that will deliver powerful
antioxidants to subcutaneous tissue beneath
the skin. The encapsulated antioxidants could
then be added to existing products such as
sunscreen and cosmetics, and improve their
abilities to prevent skin cancer and wrinkles.
Future possible products from this platform
technology include treating cancer and symptoms of stroke.
Activities
Where are they now?
Vireo Resources
UNeMed Seminars
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70
60
50
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20
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23
UNMC Photo
Prommune Inc.
UNMC Photo
Founded in
2006, Virtual Incision Corp. is
the product of
surgical devices developed at UNL and UNMC. The
company has attracted more than $3
million in private investments, most
recently a $500,000 match from Invest
Nebraska in January 2013. Virtual Incision is developing a product line
of surgical robots including those
depicted on the cover that are expected to make surgical procedures
safer, cheaper and less invasive.
Innovation Week
Activities
Education
Academic research institutions are charged with missions
concerning not only the pursuit
of knowledge through research,
but also with the education of students in areas such as scientific
disciplines and the management
of ideas, money and time so they
may be successful in their future
careers. Many of those careers
will impact public sector areas
such as economic growth and
public health, so the education of
campus investigators in the effects
of developing, marketing, and
transferring novel technologies to
the market falls within UNeMeds
core mission.
Campus education provides
investigators with the knowledge
to contact UNeMed when initial
discoveries are made; and ensures that the University has the
best chance of developing and
successfully licensing a technology that leads to significant and
sustained revenue.
To aid in the education of the
campus community, UNeMed
engages in different types of outreach programs, including those
that aim to educate the campus
in general, and specific programs
focusing on individuals who show
an interest for a career in transferring technologies to the commercial sector. UNeMeds postdoc and intern programs serve to
educate individuals, while open
seminars and UNeMeds Innovation Week activities provide general exposure and education to
all campus personnel.
Through these efforts, UNeMed
seeks to create a culture of innovation, where all UNMC faculty, staff, and students are both
knowledgeable and conscious
of the possibilities of developing
and transferring valuable technologies from UNMC to the private sector.
Win-Win
Postdoctoral Program
Activities
Services
Sizzling steaks drew a steady stream of vistors to Nebraskas booth during the
international BIO conference in Chicago. UNeMed representatives used the oppotunity to build new relationships in the global biomedical community.
Consulting services
offered at Roosevelt University
UNeMed uses existing personnel and capabilities to provide outside institutions with
invention evaluations, market potential analysis, intellectual property landscape analysis,
and marketing efforts, if applicable.
Most recently, UNeMed has worked with
Roosevelt University, a sprawling campus
of 6,343 students in downtown Chicago and
nearby Schaumburg, Ill. UNeMed will serve
as Roosevelts back office for technology
transfer, helping them establish intellectual
property policy and procedures, evaluate new
inventions and establish and pursue a marketing plan to discover industry partners.
As a regional leader
in technology transfer, UNeMed is establishing itself as
more than a mere extension
of the University of Nebraska
Medical Center.
In addition to consulting
services for smaller institutions, UNeMed also expends
a fair amount of energy
building and maintaining its
reputation as a valuable resource within the intellectual
property, small business and
biotechnology communities.
UNeMed has executed
agreements with external institutions, takes a leadership
role in the local entrepreneur
and startup community, offers educational seminars
and is a visible member of
the international biotechnology industry.
UNeMeds effectiveness
in these services is largely
due to the make-up of its talented staff and personnel. In
addition to a staff of biomedical and intellectual property
experts, UNeMed has also
added the business and clinical perspective with a physician- and entrepreneur-in-residence. (See page 15.)
Expanding reach
Breakthough malaria
drug will treat millions
n UNMC, UNeMed gift
cutting edge treatment
to developing world
College of Pharmacy.
Dr. Vennerstrom is now working
on improving the already powerful
compound, which now requires malaria sufferers to undergo a threedose regimen over three days.
Currently in Phase II studies, the
improved version could reduce the
number of treatments to one, effectively curing a malady that strikes
200 million people worldwide with a
single pill.
24
2
20
2
16
1
10
19
17
14
22
12
2009
2010
2011
2012
2013
THE WOR
UNeMeds grasp re
In fiscal 2013, UNe
foreign countries.
Australia
Belgium
n Canada
n China
n Czech Republic
n Denmark
n England
n
n
UNeMed Metrics
UNMC Patents
A look at the cumulative number of patents from research
at the University of Nebraska Medical Center.
U.S. Patents...............................345
Pending................................ 228
Foreign Patents.........................157
Pending................................ 90
$141.62 million
research expenditures in 2012
$1.46 million
gross revenue
RLD IS FLAT
66
Japan
Malaysia
n North Korea
n Russia
n South Africa
n Spain
n Switzerland
104
64
om bench to bedside
strongholds such as Europe, China and Japan.
Once UNeMed finds a commercial partner that
can continue to support the development of the
technology, UNeMed negotiates a licensing agreement to ensure that the innovation is developed,
and that UNMC is compensated for its support in
the development of the technology.
Compensation may include licensing fees, equity, running royalties, milestone fees and other
contractual obligations. In the case of Synriam,
the malaria treatment featured on page 10, UNeMed waived compensation to ensure the technology would reach its full potential and benefit those
who need it most.
In addition, commercial partners often continue
to work with UNMC through the use of sponsored
11
UNeMed Metrics
Stretching the research dollar
A strong testament to the amount and quality of research at
the University of Nebraska Medical Center can be seen with a
careful look at data provided by the Association of University
Technology Managers or AUTM. In fact, UNMC is dollar-fordollar one of the most creative and innovative universities in
the nation, if not the world.
In 2012, UNMC accounted for $141.62 million of the $394.74
million the University of Nebraska spent on research. Research
heavyweights such as Johns Hopkins University and Stanford
University spend five to 10 times more on research, yet UNMC
compares favorably across the board when research activities
are viewed in proportion to the amount of money spent. UNMC
leads a group of selected peers and even the national elite
by most measures.
For example, UNMC researchers developed 7.48 new inventions for every $10 million spent in 2012, well beyond the
peer group average of 4.05, and more than double the national
average of 3.56.
Elite schools and other selected notable institutions including Stanford, Johns Hopkins, Harvard, Columbia and most
Big Ten schools reported an average of just 0.16 new inventions for every $10 million spent.
UNMCs trend as a research leader can also be seen by using the same approach to view licensing agreements.
UNeMed helped secure 1.34 licensing deals for every $10
million in research spent, more than five times the national
average (0.24). The peer group averaged 0.94 licensing agreements for every $10 million spent.
How UNMC compares to the peer group average per $10 million in research expenditures in 2008-2012, according to data provided by the Association of University Technology Managers.
2011
n
n
n
n
n
n
n
n
n
n
n
n
n
n
4.05
2010
3.67
2009
3.6
2008
4.05
3.92
5.18
4.09
6.11
7.48
7.37
2012
Kansas University
Northwestern University
Ohio State University
Oklahoma University
Oregon Health & Science University
University of Arizona
University of Cincinatti
University of Colorado
University of Florida
University of Illinois (Chicago-Urbana)
University of Iowa
University of Kentucky Research Foundation
University of Tennessee
University of Utah
2011
.94
1.34
.85
2010
.6
2009
.85
1.23
12
2008
.8
1.13
0.3
.86
1.06
0.6
2012
UNeMed Metrics
UNeMed Licensing Agreements
(1999-2013)
80
70
60
40
20
18
10
19992003
44
30
80
50
20042008
20092013
$8
million
10.76
$7
million
$6
million
$5
million
$4
million
$3
million
400
146
2.75
150
19992003
257
200
20042008
390
250
50
19992003
20042008
$2
million
300
100
1.29
350
$1
million
20092013
20092013
13
UNeMed Metrics
1213
300
0
20092013
500
400
433
880
20042008
600
354
511
19992003
900
20042008
20092013
300
200
146
100
19992003
70
40
50
29
13
60
50
18
4 7
17
2009
2010
2011
29
6 6 7
Foreign
Patents Issued
10
Non-Provisional
Patent Applications
21
20
10
Provisional
Patent Applications
5 8
29
12
Patents
Issued
14
30
15
16
10
44
20
8 14 10
26
30
39
40
2012
Patent Cooperation
Treaty Applications
2013
Foreign Patent
Applications
New Additions
Entrepreneur-in-residence
UNeMed has enjoyed the benefits of
an entrepreneur-inresidence since Gary
Madsen, Ph.D., joined
the staff in June 2012.
He was brought in
to help identify promising UNMC technologies that have the
potential to form the
basis of new startup companies.
Dr. Madsen recently signed a one-year
extension, and also established ProTransit Nanotherapy, LLC, a company based on
technology invented at UNMC. (See page 6)
He joined UNeMed following a successful, three-decade career in biotechnology
product and business development. Previously, he worked in several biotech companies in Madison, Wisc., including Gilson,
Third Wave Technologies (Hologic), Promega and EraGen Biosciences. He began
his biotechnology career at Abbott Laboratories, then served as vice president of
research and development at IDEXX Labs
in Westbrook, Maine.
Physician-in-residence
In May 2013, UNeMed created a physician-in-residence position, and signed Deepak
Madhavan, M.D., to the
role.
Dr. Madhavan is
the director of The Nebraska Medical Centers comprehensive
epilepsy program and
an assistant professor at UNMCs Department of Neurological Sciences.
As researchers develop new ideas on
campus, Dr. Madhavan will bring his rare
experience as a businessman and practicing physician to help get those innovations
closer to patient bedsides.
Before joining UNMC, Dr. Madhavan
founded in 2009 a private practice focused
on treating epilepsy, Midwest Regional
Epilepsy Associates. He is also the president of Lifestyle Innovations for Epilepsy,
or LIFE, an Omaha-based nonprofit dedicated to the wellbeing of people living
with epilepsy.
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199
2!
Residence Programs
UNMC researcher
Dan Anderson (center)
interviews with a local
television reporter in
early July about a
new coronary artery
disease blood test he
and his co-inventors,
Dr. Geoff Thiele and
Michael Duryee, are
developing.
15
Featured Technologies
Double Threat
Vitals
Photo: UNMC
Rundown
n Novel compound
n Accurate diagnostic
n Track cancer growth
n Image and kill cancer cells
n Effective against prostate cancer
n Comprehensive, successful cellular and
animal studies
Investigation New Drug application has been filed with the FDA.
UNMC plans to start a clinical trial in prostate cancer patients soon.
Inventors
n Amarnath Natarajan, Ph.D.
n Qian Chen, Ph.D.
n Vashti Bryant, Ph.D.
n Rajkumar Rajule
16
Photo: UNMC
Rundown
n Novel drug
n Orally Available
n Few side effects
n Potent inhibitor of cancer
cell proliferation
n Effective in pancreatic
cancer animal model
n Treat other forms of cancer
n Treat diabetes, other
diseases
Dr. Natarajan
able to increase the odds for those who receive the grim
news. Researchers at UNMC are working on a novel drug
called 13-197 that has shown promise in mouse models
with relatively few side effects.
13-197 is still in preclinical development for pancreatic cancer, and may be useful in the treatment of other
forms of cancer and other diseases such as diabetes.
UNMC is interested in partnering with a pharmaceutical company to further develop 13-197 and future analogs for clinical use.
Featured Technologies
Novel Biofilm Therapy
Vitals
Rundown
n Innovative therapy
n Personalized meds
n Use patients cells
n Prevent biofilm formation
n Treat established infections
n Reduce risk of developing
antibiotic resistant bacteria
ness. By using a patients own immune system rather than anitibiotics, this approach also decreases the
likelihood of developing antibiotic
resistant bacteria.
Photo: UNMC
Inventors
n Tammy Kielian, Ph.D.
n Mark Hanke, Ph.D.
ously difficult to treat without removing or replacing the medical device. Treatment is further hindered
by the development of antibacterialresistant strains of microbes. But
researchers at the University of Nebraska Medical Center discovered
a new way to combat device-related
infections.
Rather than pursue traditional
routes of treatment with antibiotics,
UNMC researchers developed a novel
method that treats, controls and even
prevents biofilms.
The method is a cell-based therapy that uses a patients own immune
cells, specifically macrophages. The
immune cells are isolated and activated outside the body, then used as
needed to prevent or treat a biofilm
infection.
The cell-based therapy has been
tested to show significant effective-
Dr. Kielian
Intuitool
Dr. Oleynikov
Vitals
Rundown
n Intuitive interface
n Ergonomic design
n Shorter learning curve
n Shorter procedures
n Shorter patient recovery
n Better Patient Care
Inventors
n Dmitry Oleynikov, M.D.
n Susan Hallbeck, Ph.D.
17
Featured Technologies
Cancer Vaccine
Photo: UNMC
Vitals
Rundown
n Tumor-specific immunity
n Vaccine for all MUC1 cancers
n Increase anti-tumor response
n Use the bodys own immune cells
n Halts tumor growth
n Will not create an
autoimmune response
n Extend patient survival
Inventors
n Tony Hollingsworth, Ph.D.
n Karl Kohlgraf, M.D.
n Tom Caffrey
Dr. Hollingsworth
Inventor
n Guangshun Wang, Ph.D.
Photo: UNMC
18
Glyoxalase-1 targets
and degrades the suspected cause of these
complicationsa
naturally occurring chemical,
methylglyoxal, which is
created by damaged cells
when blood sugar levels
are high.
Currently there are no
FDA-approved treatments
that target brain complications in diabetes and also
help manage blood sugar
levels. But with a committed partnership, Glyoxalase-1 could be the first.
Vitals
Rundown
n Prevent cognitive
dysfunction
n Reduce cerebrovascular
complications
n Minimize affected brain
tissue following stroke
n Treats other diabetic
complications
n Reduce brain complications
n Manage blood sugar
n Targets damaged cells
Inventor
n Keshore Bidasee, Ph.D.
Featured Technologies
Research from Dr. Dong Wang
Detect, stop brain injury
immediately after head trauma
Diagnosing and effectively
treating a traumatic brain injury has been nearly impossible.
But thanks to researcher
Dong Wang, Ph.D., at the University of Nebraska Medical
Center, the 1.7 million people
who suffer head trauma each
year might finally receive effective treatment.
Sooner or later, patients
with traumatic brain injuries
develop irreversible neurodegenerative disease, which
can include memory problems,
mental decline, and full cognitive dysfunction leading to
dementia. Traumatic brain injury can also lead to significant
personal, social and economic
losses.
Unfortunately, there is no
way to detect and stop a traumatic brain injury after the actual head trauma occurs.
But the novel prodrug PDex carries imaging agents
and potent anti-inflammatory
Vitals
Rundown
n Diagnostic imaging
prior to symptoms
n Minimizes permanent
brain injury
n Delivers antiinflammatory to injury
n Image, treat
simultaneously
n Safe, non-toxic
n Proof of concept
in animal models
n Comprehensive
patent rights available
drugs into the brain to help visualize and treat the affected
area.
Both imaging and therapeutic agents are directed to
the precise area of inflammation and injury by the systems
unique targeting chemistry.
Vitals
Photo: UNMC
Vitals
Rundown
n Novel composition
n Reduce dexamethasone
side-effects
n Reduce renal damage
n Better efficacy
n Less frequent dosing
n Less expensive
19
Featured Technologies
Inventors
n Jyothi Arikkath, Ph.D.
n Dipika Singh
Photo: UNMC
Rundown
n Novel formulation
n Maintain high viability
(75-90%) upon thawing
n Freeze primary hippocampus
and cortical neurons
n Works with rat and
mouse neurons
n Save cells from wild type or
genetically-engineered animals
n Never again
waste leftover cells
n Reduce costs
n Retain up to 90 percent
viability in frozen brain cells
20
Vitals
Photo: UNMC
One of the largest challenges facing elderly care is striking the proper
balance between monitoring health
while maintaining independence.
Solutions exist, but they are generally expensive and have limited applications.
Stephen Bonasera, a researcher at
the University of Nebraska Medical
Center, found an elegant solution: A
wireless system that caregivers can
use remotely to track patients around
the clock with little more than a modern cell phone and a few well-placed
transmitters in the home.
The cost-effective solution, called
the Lifespace Monitoring System,
measures a persons movement patterns around the home to develop a
baseline of regular activity.
With minimal intrusion, Lifespace
can then detect minor changes in activity, which could indicate the onset of
several mental or physical conditions.
Dr. Bonasera
Rundown
n Novel
n Inexpensive
n Accurate, non-intrusive
collection of patient info
n Real-time information
n Reduce intervention costs
n Better information,
better results
n Constant and continuous
monitoring
n Improve response times
Inventor
n Stephen Bonasera, M.D.
UNeMed VISION
UNeMed VALUES
n Innovative Vision
n Integrity & Stewardship
n Excellence
n Dedication
Physical Address:
4460 Farnam Street, Suite 3000
Omaha, NE 68198-6099
Mailing Address:
986099 Nebraska Medical Center
Omaha, NE 68198-6099
402-559-2468
unemed@unmc.edu
http://www.unemed.com
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986099 Nebraska Medical Center | 4460 Farnam St., Ste. 3000 | Omaha, Nebraska 68198-6099
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