Th 2 Thng 11 14 (HealthDay News) - triu chng vim i trng Nghin cu s b cho thy

rng mt liu tim duy nht ca mt protein nhn to c th lm gim nng cholesterol "xu".

a ra trong bng, AMG145 gim mc lipoprotein (LDL) cholesterol mt thp trong mt

nhm ngi tnh nguyn khe mnh. C tt mt iu cholesterol va c xc nh, PCSK9, m
cn tr kh nng ca gan xa cholesterol xu trong mu.

Nhng pht hin ny c trnh by th hai ti Hip hi Tim mch M (AHA) hp hng nm
ti Orlando, Fla. Nghin cu c ti tr bi nh sn xut AMG145 Amgen Inc.

Cholesterol cao l mt yu t nguy c chnh gy bnh tim. Cc bc u tin hng ti vic

gim cholesterol thng l thay i li sng, trong bao gm n mt ch n ung t cht bo
v cc hot ng th cht thng xuyn. i vi mt s ngi, thuc nh statin phi c b
sung c c mc cholesterol ni h nn c. Ngay c iu ny l khng c c
s ca mi ngi vo vng an ton, v khng phi ai cng c th chu ng thuc hin ang c
sn. Mt LDL di 100 mg / dL mu c coi l ti u.

Tc gi nghin cu Clapton Dias, khoa hc y t gim c dc l lm sng v pht trin ban u

ti Amgen, Thousand Oaks, Calif., cho bit bc nh ny c th c a ra nh l mt add-on
cho cc liu php lm gim cholesterol hin ti cho nhng ngi khng nhn c thp h cn
phi hoc l mt iu tr c lp cho nhng ngi khng th chu ng c cc loi thuc h
lipid mu hin c.

"Bnh tim mch l nguyn nhn s mt gy t vong M, v trong khi statin rt c hiu qu, t
l tt ca nhng ngi khng p ng mc tiu ca h, nguyn nhn vim i trng v trong
thit lp ny bn c th l mt b sung c gi tr," ng ni.

Nghin cu bao gm 54 n ng v hai ph n tui t 18 n 45 ngi khng c nng

cholesterol. Nhng ngi tham gia nhn c mt trong nm liu thuc mi chuyn qua bn

hoc tim tnh mch hoc gi dc. Cc nh nghin cu o nng cholesterol LDL cho 85-113
ngy sau khi iu tr.

Cc loi thuc mi t c mc tiu ca mnh, PCSK9, v gim mc cholesterol LDL

bng cch ln n 64 phn trm. C cng c gim thy nng cholesterol ton phn v apoB (ht m nh trong mu m cn lm tng nguy c bnh tim). Mc triglyceride v cholesterol
"tt" HDL khng thay i do thuc v khng c tc dng ph nghim trng bo co. By gi,
cc nh nghin cu ang th nghim bn mi nhng ngi c mc cholesterol cao.

Bc s tim mch lc quan thn trng v cc liu php mi.

Cu Tng thng AHA Tin s Ralph Sacco ni rng cn qu sm a ra bt k d on v vai

tr g, nu c, liu php ny s c trong vic gim mc cholesterol, nhng n trong mt ngy c
th lp y mt khong trng quan trng.

"Mc d statin rt hiu qu trong vic lm gim cholesterol v gim nguy c bnh tim v t
qu, h khng cn phi c thc hin mi ngy v h c th c tc dng ph nht nh mt
s ngi," ng ni. tc dng ph Statin c th bao gm cc tn thng gan v / hoc au c bp.

"Bn mi ny c th cung cp mt cch tip cn lu di hn, c bit l nu n c th c a

ra mi thng mt ln," Sacco ni.

Tin s Dan Rader, gim c khoa tim mch phng nga ti i hc Pennsylvania, cho bit rng
PCSK9 l "mc tiu nng nht cho phng php iu tr mi gim cholesterol LDL." V
nhng kt qu nghin cu c th s y ngn la , ng ni thm.

"Mt trm gim 60-cng trong LDL vi mt liu duy nht ca khng th ny l n tng," ng
ni. " l nhng ngy u, nhng cc d liu tm kim mnh m. By gi chng ta cn nhiu

d liu hn vi nhng ngi lp i lp li liu v c theo di trong thi gian di hn,

"Rader thm.

"Vn cn rt nhiu ngi khng th t c mc LDL y vi cc loi thuc hin c, bao

gm statin", ng lu . Thm vo , thuc vim i trng ngi ta c th tm thy n d dng
hn c c mt shot mi hai tun hoc hng thng hn l ung mt vin thuc mi ngy."

Nghin cu c trnh by ti cuc hp nn c xem l s b cho n khi c cng b trong

tp ch y khoa peer-xem xt li.

Thm thng tin