RECOMBINAN

DNA
VACCINES

VACCINE

According to the Merriam Webster

Dictionary

- a substance that is usually

injected into a person or animal
to protect against a particular
disease
- a preparation of killed
microorganisms, that is
administered to produce
immunity to a particular disease

-is a technique for

protecting an organism
against disease by
injecting it with
genetically engineered
DNA to produce
immunological response

History

1950 the start of

experiments outlining
the transfer of DNA
into cells of living
animals

1992 Tang and

Johnson reported the
first successful growth
hormone in mice

1998 development
of the 1st human
antibodies

Construction

Compose of
bacterial
plasmid

Types of Vaccines
Live, Attenuated
Vaccines
These vaccines are good
teachers of the immune
system. They elicit strong
cellular and antibody responses
and often confer to lifelong
immunity with only one to two
doses

Types of Vaccines
Live, Attenuated
Vaccines
- Viruses undergo growing
generation.
- Vaccines against measles,
mumps and chickenpox are
made by this method

Types of Vaccines
Inactivated Vaccines
- Scientists produce
inactivated vaccines by
killing the disease causing
microbe with chemicals,
heat or radiation.
- Such vaccines are more
safer and stable than live
vaccines

Types of Vaccines
Toxoid Vaccines
- Vaccines for those bacteriacausing diseases that
secretes toxin or harmful
chemicals
- Taken from the host and
injected to the immune
system for adjustment and
stability

Types of Vaccines
Conjugate Vaccines
- Vaccines that are taken from
bacterium with outer coating
of sugar molecules called
polysaccharides
- Vaccine against influenza
type B is an example

Types of Vaccines
DNA Vaccines
- Genes from a microbe is
analysed and will be induced
as a vaccine and be injected
to the host so that the body
will create its antigen
molecules as a response