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    Road To Cancer

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    Sagir Alva
    This document discusses the molecular basis of cancer development. It explains that cancer arises from genetic damage, including small mutations, large changes that alter the karyotype through translocations, deletions, amplifications, and aneuploidy. Cancer development is a multistep process influenced by the dysregulation of several classes of genes involved in processes like growth promotion, growth inhibition, cell death, and DNA repair. MicroRNAs can also contribute to carcinogenesis.

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    Road To Cancer

    Uploaded by

    Sagir Alva
    26 views15 pages
    This document discusses the molecular basis of cancer development. It explains that cancer arises from genetic damage, including small mutations, large changes that alter the karyotype through translocations, deletions, amplifications, and aneuploidy. Cancer development is a multistep process influenced by the dysregulation of several classes of genes involved in processes like growth promotion, growth inhibition, cell death, and DNA repair. MicroRNAs can also contribute to carcinogenesis.

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    Original Title

    Road to Cancer

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    This document discusses the molecular basis of cancer development. It explains that cancer arises from genetic damage, including small mutations, large changes that alter the karyotype through translocations, deletions, amplifications, and aneuploidy. Cancer development is a multistep process influenced by the dysregulation of several classes of genes involved in processes like growth promotion, growth inhibition, cell death, and DNA repair. MicroRNAs can also contribute to carcinogenesis.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pptx, pdf, or txt
    26 views15 pages

    Road To Cancer

    Uploaded by

    Sagir Alva
    This document discusses the molecular basis of cancer development. It explains that cancer arises from genetic damage, including small mutations, large changes that alter the karyotype through translocations, deletions, amplifications, and aneuploidy. Cancer development is a multistep process influenced by the dysregulation of several classes of genes involved in processes like growth promotion, growth inhibition, cell death, and DNA repair. MicroRNAs can also contribute to carcinogenesis.

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    of 15

    ROAD TO CANCER:

    MOLEKULER

    DASAR MOLEKULER

    Kerusakan genetik non-letal: Karsinogenesis


    Empat kelas gen regulator normal:

    1. growth-promoting proto-oncogen (beta katenin),

    2. growth-inhibiting tumor suppressor genes (p53), TSG:


    governor atau guardian

    3. genes that regulate programmed cell death (Bcl2),

    4. gene yang terlibat dalam reparasi DNA (MSH

    LESI GENETIK
    Perubahan genetik

    1. Kecil (mutasi pada 1 titik/insersi/delesi)

    2. Besar sehinga menyebabkan perubahan

    karyotypic

    PERUBAHAN KARYOTYPIC: TRANSLOKASI

    DELESI

    POOR PANCREATIC CANCER PROGNOSIS

    AMPLIFIKASI

    NEUROBLASTOMA

    ANEUPLOIDI = NOT MULTIPLE OF HAPLOID STATE

    MICRORNA DAN CANCER

    KARSINOGENESIS : MULTISTEP
    PROCESS

    HALLMARK OF CANCER

    PERAN CDK DAN CDK-INHIBITOR DALAM SIKLUS


    SEL

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