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  • Daignosis Prenatal: Irene, Rani, Rudy, Nevin, Ritsia, Abram, Hendrik, Mirna, Prisilla, Fanny

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    Muhammad Ahmad Syammakh
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    1. The document discusses prenatal diagnosis which aims to detect congenital abnormalities and assess fetal well-being. 2. It outlines various risk factors that warrant prenatal testing and different testing methods including serum/urine tests of the mother, ultrasound exams of the fetus, and invasive or non-invasive fetal tissue sampling techniques. 3. Prenatal diagnosis evaluates the fetus through laboratory tests of chromosomes, DNA, blood cells and more, as well as through clinical exams of the mother and electronic monitoring of the fetus.

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    Original Title

    Prenatal Screening Revisi

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    1. The document discusses prenatal diagnosis which aims to detect congenital abnormalities and assess fetal well-being. 2. It outlines various risk factors that warrant prenatal testing and different testing methods including serum/urine tests of the mother, ultrasound exams of the fetus, and invasive or non-invasive fetal tissue sampling techniques. 3. Prenatal diagnosis evaluates the fetus through laboratory tests of chromosomes, DNA, blood cells and more, as well as through clinical exams of the mother and electronic monitoring of the fetus.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
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    22 views19 pages

    Daignosis Prenatal: Irene, Rani, Rudy, Nevin, Ritsia, Abram, Hendrik, Mirna, Prisilla, Fanny

    Uploaded by

    Muhammad Ahmad Syammakh
    1. The document discusses prenatal diagnosis which aims to detect congenital abnormalities and assess fetal well-being. 2. It outlines various risk factors that warrant prenatal testing and different testing methods including serum/urine tests of the mother, ultrasound exams of the fetus, and invasive or non-invasive fetal tissue sampling techniques. 3. Prenatal diagnosis evaluates the fetus through laboratory tests of chromosomes, DNA, blood cells and more, as well as through clinical exams of the mother and electronic monitoring of the fetus.

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
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    of 19

    DAIGNOSIS PRENATAL

    Irene, Rani, Rudy, Nevin, Ritsia,


    Abram, Hendrik, Mirna, Prisilla,
    Fanny

    DIAGNOSIS PRENATAL
    TUJUAN :

    A. Deteksi awal kelainan kongenital


    B. Deteksi gangguan kesejahteraan

    A. Deteksi Cacat Bawaan


    INDIKASI PEMERIKSAAN :
    1. Faktor risiko / predisposisi
    yang dapat dikenal sebelum
    kehamilan :
    Umur ibu > 35 th
    Parental consanguinity
    Kelompok etnis tertentu
    Riwayat keluarga yang
    buruk
    Riwayat obstetri yang
    buruk

    2. Faktor risiko yang dapat


    dikenal dalam
    kehamilan :
    Kelainan gambaran USG
    Kelainan kadar AFP
    Polihidramnion
    Oligohidramnion
    Infeksi ibu
    Kontak / makan obatobat dan zat kimia
    teratogenik
    Radiasi

    METODE PEMERIKSAAN
    I. Pemeriksaan serum & urine ibu :
    Triple test : kadar dalam serum
    AFP
    hCG
    Estriol
    Asam metilmalonat
    methylmalonic aciduria

    II. Pemeriksaan janin in utero :


    1. USG = Ultrasonograf
    2. Fetoskopi
    3. Radiologi

    4. MRI = Magnetic Resonance Ima


    5. Embrioskopi

    III. Pemeriksaan sel/jaringan


    janin :
    ( Fetal Tissue Sampling )
    1. Teknik invasif
    Amniosentesis

    Aspirasi darah janin


    (FBS = Fetal blood
    sampling)
    Khordosentesis
    Biopsi : khorion (CVS),kulit
    janin, hati

    AMNIOSENTESIS

    CHORIONIC VILLUS SAMPLING

    Villu
    s

    CHORDOCYNTHESIS

    2. Teknik non invasif


    Preimplantation genetic
    diagnosis
    Maternal blood sampling

    Pemeriksaan Laboratorium

    Analisis kromosom

    Analisis DNA

    Analisis Biokimia

    Analisis Hematologi

    Analisis Mikrobiologi

    Dll

    TEKNIK PEMERIKSAAN

    KROMOSOM : FISH ( Fluorescence In Situ


    Hybridization )
    DNA :* PCR ( Polymerase Chain Reaction)
    * Southern blot
    * Pulsed field gel electrophoresis
    mRNA : * Nothern blot
    * Rnase A mapping

    B. Evaluasi Kesejahteraan Janin


    1. Secara Klinis :

    Pengukuran tinggi fundus


    uteri & lingkaran perut ibu

    Pengukuran pertambahan BB
    ibu

    Evaluasi Bunyi Jantung Janin


    (BJJ)

    Pemantauan gerakan janin

    ( Fetal Kick Count : Normal > 10 /


    12 jam )

    2. Secara Biokimia :
    Pemantauan

    kadar :
    Hormon estriol
    HPL = Human placental
    lactogen
    Chorionic gonadotropin
    L/S ratio
    (Lecithine/Sphyngomyelin
    )
    pH darah janin

    3. Secara Elektronis :
    CTG

    = Cardiotocography
    USG termasuk Doppler USG
    Pemantauan Biofsik Janin
    EKG janin
    EEG janin
    FPO (Fetal pulse oxymetry)

    KARDIO TOKO GRAFI

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