Namiesnik Jacek VN

p dng k thut chun b mu xanh c lp,
lm giu v phn tch sc k cc nhim hu

c trong mi trng
Marcinkowski ukasz1, Spietelun Agata1,
Kloskowski Adam1, Namienik Jacek2
1Department
of Physical Chemistry, Chemical Faculty

of Analytical Chemistry, Chemical Faculty
Gdask University of Technology,
80-233 Gdansk, 11/12 G. Narutowicza St., Poland
*chemanal@pg.gda.pl
2Department
Analytica Vietnam , 17-19.04.2013, Ho Chi Minh City
VAI TR CA HA PHN TCH TRONG

LNH VC KHOA HC MI TRNG
Kho st hin trng mi trng v cc qu trnh xy ra
trong mi trng
Xc nh kh nhiu nhim, thng tn ti lng vt
hay siu vt trong cc mu nn c thnh phn phc tp
v bin i.
Cn phi a vo thc nghim phn tch cc phng
php v thit b phn tch mi p ng nguyn tc pht
trin bn vng v ha hc xanh.
HA HC XANH
(LCH S PHT TRIN)
Vin HA HC XANH (EPA) ra i USA.

Vin thc y s hp tc gia cc c quan
nh nc v cc tp on cng nghip, s
phi hp gia cc trng v vin nghin cu,
Nhm hot ng Ha hc xanh ca IUPAC

(IUPAC Working Party on Green Chemistry)
c thnh lp.
2003
Hi ngh quc gia u tin v HA HC

XANH c t chc Balan
EkoChemTech03
1997
Hi tho quc t u tin v HA HC

XANH
1996
1995
Chng trnh Ha hc xanh c US EPA

khi xng
Hi ng Th gii v Mi trng v Pht
trin ca lin hip quc (World Commission on
Environment and Development - WCED) xut bn
Tng lai chung ca chng ta, cn c bit
vi tn Bo co Brundtland,
Gii thng hng nm cho cc thnh tu

trong lnh vc p dng cc nguyn tc ca
HA HC XANH
1991
C quan kim sot Cht c v ngn nga

nhim a ra chng trnh h tr nghin
cu c tn Tng hp thay th ngn nga
nhim
1987
Paul Anastas a ra thut ng HA HC

XANH
1993
11. Phn tch thi gian

thc ngn nga
nhim
10. Thit k ha cht v
sn phm c th phn
hy sau s dng
12. Gim thiu nguy c

xy ra s c
1. Trnh pht thi

2. Tng hiu sut nguyn t
trong cc qu trnh ha hc
(atom economy )
3. t tng hp ha
nguy hi
GREEN
CHEMISTRY
9. Dng xc tc
4. Ha cht v sn phm
an ton hn.
8. Trnh cc dn xut
ha hc
7. Dng nguyn
liu ti to
5. Dung mi v iu kin
phn ng an ton
6. Tng hiu qu nng
lng
Nguyn tc ca HA HC XANH
(P.T. Anastas, J. Warner, Green Chemistry.Theory and Practice,
Oxford University Press,New York, 1998, p. 30)
PRINCIPLES of GREEN CHEMICAL TECHNOLOGY
(N. Winterton, Green Chem., 3 (2001) G73)
PRINCIPLES of GREEN CHEMICAL ENGINEERING
(P.T. Anastas, J.B. Zimmerman, Environ. Sci.Technol., 37 (2003) 94A-101A.)
HA HC XANH
Ha hc xanh, l s sng to, thit k v ng dng cc sn phm v
qu trnh ha hc nhm hn ch v loi b vic s dng hay to ra cc
cht nguy hi
P. T. Anastas, J. C. Warner, Green Chemistry: Theory and Praktice. Oxford Science Publications, Oxford (1998)
HA PHN TCH XANH-GAC

S dng cc k thut phn tch ha hc v cc phng php lun
nhm gim hay loi tr dung mi, thuc th, cht bo qun v cc
ha cht nguy hi cho sc khe hay mi trng, ng thi cho php
phn tch nhanh hn, tit kim nng lng hn m khng lm gim
cc tiu ch hiu nng
H. K. Lawrence, Green Analytical Methodology Curriculum
http://www.chemistshelpingchemists.org/GreenAnalyticalMethodologyCurriculum.ppt#257,2,Curriculum
THE COMPONENTS OF GREEN ANALYSIS
D vn hnh, an ton
Gn nh, tn t nng lng
A. Gauszka, Z.M. Migaszewski, J. Namienik Twelve principles of green analytical chemistry

SIGNIFICANCE of green analytical practices. Trends Anal. Chem. Submitted.
THE PRINCIPLES OF GAC EXPRESSED AS

TM QUAN TRNG NG GHI NHN
Chn phng php trc tip

Tch hp qu trnh phn tch v iu khin
t thi hn, nu c th th x l cn thn
Khng hao ph nng lng
T ng ha v lm phng php gn li
u tin thuc th t cc ngun c kh nng ti to
Tng tnh an ton cho ngi thc hin
Thc hin cc php o in-situ
Trnh bin tnh
S mu v lng mu cng t v nh cng tt
Chn cc phng php phn tch a cht, a bin
Thay th v loi b cc tc cht c hi
A. Gauszka, Z.M. Migaszewski, J. Namienik Twelve principles of green analytical chemistry
SIGNIFICANCE of green analytical practices. Trends Anal. Chem. Submitted.
A KHI NIM PHT TRIN BN

VNG VO CC PTN PHN TCH
HA PHN TCH XANH
Tm k thut phn tch mi

Tm k thut chun b mu khng cn dungmi
Mi trng ly trch mi
Dng cht lng iontrong giai on chun b mu trc khi phn tch.
Dng nc siu ti hn lm mi trng ly trch
Cc tc ng gin tip ln cc cht

p dng visng.
p dng siu m.
p dng tia UV.
Tch hp v nhha thit b phn tch

nh gi tc ng mi trng ca cc phng th nghim v cc quy trnh
phn tch ng dng k thut nh gi vng i.
CC MC NG NH TRONG HA PHN TCH XANH

1974
Pht trin pp phn tch tim dng - FIA
1974
Pht trin k thut gii - hp th (purge-and-trap) - PT
1976
Pht trin pp. chit pha rn - SPE
1978
Pht trin pp ly trch im sng (cloud point extraction CPE)
1985
Pht trin pp ly trch bng vi sng (microwave-assisted extraction MAE)

Pht trin pp ly trch cht lng siu ti hn (supercritical fluid extraction SFE)
1987
Khi nim ha hc sinh thi (H. Malissa)

Khi nim pht trin bn vng
1990
Pht trin pp vi chit pha rn (solid-phase microextraction SPME)

Pht trin H phn tch tng vi lng (micro total analysis system - TAS)
1993
Pht trin pp chit pha rn ng du phn t (molecularly imprinted solid-phase extraction- MIMSPE
1995
Khi nim ha phn tch thn thin vi mi trng (M. de la Guardia, J. Ruzicka)
1996
Pht trin pp chit p sut cao (presurized solvent extraction PSE)

Pht trin pp chit pha lng vi lng (liquid phase micro extraction LPME)
Pht trin pp chit vi lng n git (single drop microextration SDME)
1999
Khi nim ha hc xanh (P.T. Anastas)

Khi nim ha phn tch sch ( M. de la Guardia)
Khi nim ha phn tch xanh ( J. Namienik)
Pht trin pp chit hp th trn thanh khuy (stir bar sorptive extraction- SBSE)
MI TRNG LY TRCH
DUNG MI XANH
Thng s
CO2 Siu ti hn
H2O Siu nng
tan ca cht c th thay i
10-100 ln
50-1000000 ln
Cc cht c th chit c
Cht phn cc
Cht khng phn cc
Cc cht c th chit d dng
Cht khng phn cc
Cht phn cc
Hot tnh ca cht cn phn tch
Thp
Thp trung bnh
Lm giu sau ly trch
usually easy
kh thay i
Ly trch chn lc cc cht vi

phn cc khc nhau
Trung bnh
tt
ly trch chn lc t cc mu vi
thnh phn mu nn cho trc
( t)
tt
Km
Khong bin thin phn cc

ca cc cht c phn tch ()
1-2
10-80
10
MI TRNG LY TRCH MI
DUNG MI XANH
CHT LNG ION DUNG MI CA TH K 21ST
NHNG TNH CHT HP DN V
HA HN CA CHT LNG ION
Nhng mui ny dng lng nhit phng.
Ha tan cc hp cht hu c v v c.
Bn nhit;
nht cao;
a nc/ k nc;
khng bay hi (p sut hi 25C rt thp);
dn in cao.
TNG S KT HP CATION V
ANION THEO L THUYT C TH
12
TI 10
Cho n nay bit khong 1500 CHT
LNG ION.
Mi c 500 c thng mi ha.
11
MI TRNG LY TRCH MI
DUNG MI XANH
Chun b mu giai on quan trng nht trong quy trnh phn tch tng th
KHNG TiN X L TRC PHN TCH GiI PHP HON HO

TUY NHIN c rt t k thut phn tch nh vy
Lm giu cht ch (cc cht cn phn tch ) v nng cao
hn gii hn pht hin ca my o/my quan trc.
C lp cht CH khi nn mu ban u hay n gin ha nn
Loi tr cc cht c nh hng v loi tr nhng thnh phn
hp ph bn ln ct sc k lm ct nhanh hng.
12
K THUT CHUN B MU KHNG DUNGMI

Dng dng kh tr lm mi
trng ly trch
K thut chit pha rn

kt hp vi gii hp
nhit
K thut chit bng

mng
Phn tch Ha hi tnh (S-HS)

Phn tch Ha hi ng (D-HS)
By lnh (CT)
Headspace (Ha hi)
Lm sch v by (Purge and Trap PT)

Phn tch gii loi trong ng (CLSA)
Ly trch trn gm (GPE)
Chit ng trong kim (INDEX)
By hp ph trong mao qun kim (INCAT)
Ly trch hp thu Ha hi (HHSE)
By ng h (OTT)
Chit vi lng mao qun ph (CCME)
By ng mng dy h (TFOT)
By mao qun mng dy (TFCT)
Chit hp th trn thanh khuy (SBSE)
Chit trn pha rn vi lng (SPE)
Chit vi lng trn pha rn (SPME)
Chit nano lng pha rn (SPNE)
Thit b chit pha rn quay
Khi ph mng u vo (MMS)

Chit trn mng vi b mt hp ph (MESI)
Phn tch ly mu si rng (HFSA)
Vi by cho chit mng trong dng (OLMEM)
By v gii loi trn mng (MPT)
Chit xung trn mng (PIME)

Thit b bn thm mng (SPMD)
ng dng gii hp nhit mng (TMDA)
Gii hp nhit lng k thm th ng
Chit bng cht lng

siu ti hn
K thut chit gn
nh khng dung mi
Chit pha lng vi lng dy rng (HF-LPME)

Tch / Chit mng in (EMI/EME)
Chit vi lng n git (SDME)
Rn ha git hu c tri (SFOD)

Chit vi lng Lng-Lng phn tn (DLLME)
Thit b chit pha rn quay
13
CHIT VI LNG N GiT

(SDME)
EXTRACTING
FORSDME
SDME
DUNG MI LYSOLVENTS
TRCH TRONG
DI-SDME
HS-SDME
IL-SDME
n -Hexane
n -Octane
iso-Octane
Cyclohexane
n -Hexadecane
Butylacetate
Diisopropyl ether
n -Octane
n -Decane
Tetradecane
Ethylene glycol
Toluene
o -Xylene
1-Octanol
BMIM PF 6
HMIM PF 6
OMIM PF6
HMIM NTf 2
Dung lng git
1 8L
chn lc cao
Gii hn pht hin thp

n gin, nhanh, d
Chun b mu nhanh gn
T ng ha nh tr gip ca cc thit b c thng mi
C kh nng p dng cho phn tch vt trong nc
G. Liu, P.K. Dasgupta, Anal. Chem. 68 (1996) 1817
DI-SDME: direct immersion

HS-SDME: headspace
IL-SDME:ionic liquid-base
14
Cc ch chit SDME
CONTINOUS
FLOW
DNG LIN
TC
W. Liu, H.K. Lee, Anal. Chem., 72 (2000), 4462
LLLME
CHT
NHNG TRC TiP
HA HC
L. Xu, C. Basheer, H.K. Lee. J. Chromatog. A, 1152 (2007), 184
DROP-TO-DROP
GiT TRONG GiT
DMD-LPME
LNG
ION
Git = Mng Git - LPME
M. Ma, F.F. Cantwell, Anal. Chem.,

70 (1998), p. 3912
H.F. Wu, J.H. Yen, C.C. Chin, Anal. Chem.,

78 (2006) 1707
T. Sikanen, S. Pedersen-Bjergaard, H. Jensen, R.

Kostiainen, K. E. Rasmussen, T. Kotiaho,
Anal. Chim. Acta 658 (2010) 133
15
CHIT VI LNG NG C GiT HU C

TRI (SFOD/SFOME)
Tnh cht ha l ca dung mi dng

trong SFOME:
Khng trn ln vi nc
bay hi thp
T trng thp
C kh nng ly trch cht cn phn tch
Dung
mi solvents
thng dng
Common
used
in SFOME
1-Undecanol
o
Melting
point
Nhit
si( C)
13-15
1-Dodecanol
22-24
2-Dodecanol
17-18
n-Hexadecane
18
1,10-Dichlorodecane
14-16
Organic solvent
M.R.K. Zanjani, Y. Yamini, S. Shariati, J. . Jnsson, Anal. Chim.Acta, 585 (2007) 286
16
CHIT VI LNG PHA LNG DY

RNG (HF-LPME)
R, n gin, sch
C th t ng ha
Thch hp cho phn tch GC, HPLC, CE
chn lc v linh hot cao
Ch Ha hi/nhng
Kh nng bin tnh in-situ
HF-LPME c th c:
Ch ba pha (a)
Ch hai pha (b)
TIN B TRONG K THUT HF-LPME :

Chit vi lng Lng-Lng-Lng Mng trn
dy rng (HFM-LLLME)
Chit vi lng pha lng dy rng ng HFLPME
Fig. D. Han, K. H. Row, Microchim. Acta,176 (2012) 1
Chit vi lng pha lng dy rng ng dung

mi lnh HF-LPME (SC-DHF-LPME)
17
C LP MNG iN HA (EMI)
CHIT MNG iN HA (EME)
EME trn chip
S. Pedersen-Bjergaard, K.E. Rasmussen, J. Chromatogr., A 1109 (2006) 183.
M. D. Ramos Payn, H. Jensen, N. J. Petersen, S. H. Hansen, S. Pedersen-Bjergaard, Anal. Chim. Acta, 735 (2012) 46
18
CHIT VI LNG PHN TN LNG

LNG (DLLME)
Fig. A. V. Herrera-Herrera, M. Asensio-Ramos, J. Hernndez-Borges,

M. . Rodrguez-Delgado, Trends Anal. Chem., 29 (2010) 728
R, n gin, nhanh
D thc hin
C th t ng ha
Din tch tip xc gia mu v pha nhn ln
Thch hp cho phn tch bng GC, HPLC, CE v UV-vis
ng hc ly trch nhanh
H s lm giu mu cao
M. Rezaee, Y. Assadi, M.R.M. Hosseini, E. Aghaee, F. Ahmadi, S. Berijani, J. Chromatogr., A 1116 (2006) 1.
19
Tin b trong chit vi lng phn tn Lng-lng

DLLME tr gip bng vi sng
DLLME tr gip bng lc xoy
DLLME tr gip bng cht hot ng b mt
DLLME gii nh tng ha bng dung mi

DLLME kt thc bng dung mi
DLLME gii nh tng ha vi dung mi t trng thp
DLLME tim tun t
Dung mi ly trch mi
DUNG MI LY TRCH NHE HN NC
THIT B LY TRCH CHUYN DNG T CH TO
DLLME GiT HU C TRI RN

CHT LNG ION
CHIT VI LNG DA TRN KT TP LNH (CIAME)
CHIT VI LNG TO DUNG MI IN SITU (ISFME)
DLLME CHT LNG ION KiM SOT NHIT (TILDLME)

GiT T V MIXEN O
20
THIT B CHIT PHA LNG QUAY
Hollow Fiber Solid-Liquid Phase Microextraction (HFSLPME)
Stir Membrane liquidliquid microextraction

(SM-LLME)
Z. Eshaghi, M. A.-K. Khooni, T. Heidari,

Spectrochim. Acta Part A, 79 (2011) 603
M. C. Alcudia-Len, R. Lucena, S. Crdenas, M. Valcrcel,

Anal. Chem., 81 (2009) 8957
Dual Solvent Stir Bars Microextraction

(DSSBME)
C. Yu, Q. Liu, L. Lan, B. Hu, J. Chromatogr. A, 1188 (2008) 124
Solvent Bar Microextraction

(SBME)
X. Jiang, H. K. Lee, Anal. Chem., 76 (2004) 5591
21
THIT B CHIT PHA LNG QUAY
Modes:
bar adsorptive - extraction (BaE)
multi-spheres adsorptive -extraction (MSAE)
Stir cake sorptive extraction (SCSE)

X. Huang, L. Chen, F Lin, D. Yuan, J. Sep. Sci., 34 (2011) 2145
Adsorptive -extraction (AE)

N.R. Neng, A.R.M. Silva, J.M.F. Nogueira, J.Chromatogr. A, 1217 (2010) 7303
Rotating disk sorbent extraction (RDSE)

P. Richter, C. Leiva, C. Choque, A. Giordano, B. Sepulveda,
J. Chromatogr. A, 1216 (2009) 8598
Stir rod sorptive extraction (SRSE)

Y. B. Luo, Q. Ma, Y. Q. Feng, J. Chromatogr. A, 1217 (2010) 3583.
22
CHIT HP THU THANH KHUY

(SBSE)
Nhanh, n gin, khng dung mi
Ly trch nhy v hiu qu

Thch hp cho phn tch bng GC, HPLC, CE
Ch Ha hi v Nhng trc tip
Nhit v ha hc ca lp ph thanh khuy n nh
Tin b trong k thut SBSE:
p dng mt xp poliurethane, PPESK, alkyl-diolsilica
RAM, vt liu silica, lp ph phn t ng du, k thut
monoliths (nguyn khi) v sol-gel ch to lp ph
thanh khuy.
Lp ph thanh khuy nh pha
E. Baltussen, H. G. Janssen, P. Sandra, C. A. Cramers, J. High. Resolut. Chromatogr., 20 (1997) 385
23
Chit pha rn vi lng (SPE)

R, n gin, sch
D p dng
D thao tc
Thch hp cho phn tch GC, HPLC
Ch Ha hi v Nhng
nhy m bo
lp li tt
lm giu tuyt vi
Tin b trong k thut (SPE) :

ng dng ti giy gn, si composite polyaniline-nylon-6
(PANI-N6) v si polypyrrole-polyamide (PP-PA) iu ch
bng phng php spin in ha ch to tm hp thu.
C. Basheer, A. A. Alnedhary,B. S. M. Rao, S. Valliyaveettil, H. K. Lee, Anal. Chem., 78 (2006) 2853

24
ng dng ht nano trong k thut ly trch quy

m nano
THY TINH KCH THC
MICRO VI HT NANO Au
MU NC
LC V LYTM
THUKT TA
THM DUNGMI
LC V LYTM
LY TH NI TRN MT
HPLC
LETRESS
PHNG N I
H. Wang, A. D. Campiglia, Anal. Chem., 80 (2008) 8202
PHNG N II
Y. Zhu, S. Zhang, Y. Tang, M. Guo, C. Jin, T. Qi,
J Solid State Electrochem, 14 (2010) 1609.
ChiT nano pha rn (SPNE)

H. Wang, A. D. Campiglia, Anal. Chem., 80 (2008) 8202
25
CHIT VI LNG PHA RN

(SPME)
Thao tc n gin
Thi gian ly trch v gii hp ngn
Hon ton khng dung mi
Kch thc rt nh (tin thit k thit b bn)
C th hon ton t ng ha
Kt ni trc tip vi GC
Kh nng ly mu in-situ v in-vivo
Ch Nhng trc tip hay Ha hi
1.
2.
3.
4.
5.
u trn
ng rng
Bao kim
Kim trong
Dy silica ph nng
C. L. Arthur, J. Pawliszyn, Anal. Chem., 62 (1990) 2145

26
CC MC PHT TRIN
PHNG PHP SPME
SPME Ha hi
(HS-SPME)
SPME MNG
(M-SPME)
SPME LNH TRN SI PH

(CCF-SPME)
SPME DY TRONG NG
SPME SI TRONG NG
SPME TRONG NG
27
TiN B TRONG K THUT

SPME
T NG
PHA LY TRCH MI
CHT LNG ION
CARBON NANOTUBES V GRAPHEN
SILICA CU TRC MICRO
THIT B MI V CC CI TiN
SPME MNG
CHIT VI LNG LNG-LNG-RN
SPME GIA TC BNG iN HP PH
28
SI CHO SPME TRN TH TRNG

HP TH
t la chn
C th c s phn hy
Gii hp khng hon ton

Tng tc xc tc gia cht hp th v
cht b bt gi
chn lc km cho
cht phn cc
kh nng cnh tranh chim cc tm hp ph
gia cc cht nn v cht ch
HP PH
Cn nhit cao gii hp cc cht kh bay

hi
Nhit gii hp thp
S phn hy cht cn phn tch

Xc tin, xc tc s phn r cc cht ch
c bt gi
Cht b bt ha tan trong pha hp phu

Cht b bt gi khng b phn hy
Khng c tng tc c bit gia cht
b bt gi v pha hp ph
analyte and sorbent
29
CHIT VI LNG LNG-LNG-RN
n gin
chi ph thp rt hp dn
thn thin vi mi trng
lng dung mi khng ng k
hiu nng cao
x l chn lc v nhy
Y. Hu, Y. Wang, Y. Hu, G. Li, J. Chromatogr. A, 1216 (2009) 8304
30
SPME HP PH iN HA GIA TNG

(EE-SPME)
n gin, nhanh, nhy

Hiu sut tt
Thi gian hp ph ngn
Khong tuyn tnh ln
LOD thp
phc hi cao
Q. Li, Y. Ding, D. Yuan, Talanta 85 (2011) 1148
Phng php ly trch vi in cc lm vic ph ht nano c

bit vi tn:
LY TRCH NANO PHA RN iN HA
X. Chai, Y. He, D. Ying, J. Jia, T. Sun, J. Chromatogr. A, 1165 (2007) 26 Y. Zhu, S. Zhang, Y. Tang, M. Guo, C. Jin, T. Qi, J. Solid State Electrochem, 14 (2010) 1609.
31
SPME TRN MNG (M-SPME)
1) Dy silica
2) Lp ph polyethylene glycol (PEG)
3) Lp ph polydimethylsiloxane (PDMS)
Vt liu hp ph
B dy trung bnh ca lp ph
Chiu di lp ph
Vai tr ca lp ph cht hp ph
Lp ph trong
PEG
40-50m
1cm
Mi trng bt gi
cht rt phn cc
Lp ph ngoi
PDMS
100-110m
1,2 cm
K nc, mng khng
phn cc
A. Kloskowski, M. Pilarczyk, J. Namienik, Anal. Chem., 81 (2009) 7363.

32
U iM CA SPME TRN MNG

Chi ph cho dy rt thp
bn nhit cao (PDMS bn cho n 300oC)
thi gian ly trch v gii hp ngn
nc khng b hp thu (nh lp mng k nc)
i lc cao vi hp cht phn cc
nhit ly trch, PEG phn t lng thp hot ng nh l
cht lng b c nh (polymer lng nht)
Cht cn phn tch b bt gi nh ha tan vo lp hp ph

Bn cht hp ph ca s bt gi
C ch phn tch ca qu trnh gii hp
33
Xc nh phenols
Bng SPME mng v GC
Khong
tuyn tnh
(g/L)
R2
15-1500
2-Chlorophenol
Hp cht
LOD (g/L)
M-SPME
PA
0.9953
50
3-300
0.9936
43
530
2,4-Dichlorophenol
3-300
0.9987
15
120
2,4-Dimethylphenol
3-300
0.9921
110
2,4-Dinitrophenol
10-1000
0.9963
110
950
2-Methyl-4,6-dinitrophenol
15-1500
0.9898
81
680
2-Nitrophenol
3-300
0.9945
60
4-Nitrophenol
15-1500
0.9937
150
1800
Pentachlorophenol
15-1500
0.9914
83
740
2,4,6-Trichlorophenol
10-1000
0.9932
61
440
4-Chloro-3-methylphenol
A. Kloskowski, M. Pilarczyk, J. Namienik, Anal. Chem., 81 (2009) 7363
34
Xc nh VOCs
Bng SPME mng v GC
R2
Compound
chlorobenzene
p-xylene
o-xylene
isopropylbenzene
n-propylbenzene
2-chlorotoluene
4-chlorotoluene
t-butylbenzene
sec-butylbenzene
1,3-dichlorobenzene
1,4-dichlorobenzene
1,2-dichlorobenzene
LOD (mg/L)
RSD (%)
M-SPME
DVB/CAR
/PDMS
M-SPME
DVB/CAR
/PDMS
M-SPME
DVB/CAR
/PDMS
0.997
0.992
0.986
0.994
0.998
0.997
0.995
0.997
0.987
0.989
0.994
0.986
0.994
0.986
0.994
0.995
0.997
0.993
0.995
0.985
0.992
0.998
0.987
0.988
0.031
0.022
0.018
0.015
0.013
0.016
0.017
0.011
0.011
0.017
0.017
0.016
0.016
0.015
0.014
0.018
0.017
0.019
0.018
0.021
0.021
0.017
0.023
0.028
11
9
12
12
14
8
10
12
11
14
13
13
9
6
7
8
10
6
6
8
8
10
7
7
35
Kt lun v SPME mng

C ch phn tch ca qu trnh chit c trng bi khong tuyn tnh ln hn so vi cc
si ly trch trn th trng.
Cho php dng cc cht hp ph phn cc mnh m khng c nguy c tan vo nn mu
phn cc
Cho c hi ng dng cc vt liu hon ton mi m cho n nay khng c ch ti do
c nhit nng chy thp hay tan trong nc
Hiu sut ly trch cao phenols v VOCs bng ly trch vi lng pha rn mng trn dy,
bng v cao hn so vi dng dy c trn th trng
M-SPME kt hp vi GC c th tr thnh cng c hu

hiu v thn thin vi mi trng ly mu, c lp v
lm giu cc nhim hu c.
c th p dng trong giai on chun b mu c nng
ppb trc bc nh lng cui cng.
36
NH GI TC NG MI TRNG CA CC
QUY TRNH PHN TCH
CNG C:
nh gi vng i (LCA)1
Quy m sinh thi 2
Phm vi sinh thi 3
Consoli, F., D. Allen, R. Weston, I. Boustead, J. Fava, W. Franklin, A. Jensen, N. de Oude, R.
Parrish, R. Perriman, D. Postlethwaite, B. Quay, J. Sguin and B. Vigon., Guidelines for life cycle
assessment: A Code of practice. SETAC, Brussels and Pensacola, 1993.
1
Aken K., L. Strekowski, L. Patiny, EcoScale, a semi-quantitative tool to select an organic

preparation based on economical and ecological parameters, Beilstein J. Org. Chem. 2, 3, 2006.
3 Home
Sustainability Assessment, http://www.ecocompass.com.au/
37
QUY M SINH THI CA

PHNG PHP PHN TCH
Cng c mi nh gi xanh ca ca phng php phn tch
Quy m sinh thi = 100 tng s im pht
Kt qu c nh gi nh sau:
>75 phn tch xanh tt
>50 phn tch xanh chp nhn c
<50 khng t phn tch xanh
im pht c cho da trn lng cht, ri ro (vt l, mi trng, sc khe v ngh
nghip), nng lng tiu hao v cht thi trong mt qu trnh phn tch.
Gauszka A., Konieczka P., Migaszewski Z.M., Namienik J. 2012. Analytical Eco-Scale for assessing the greenness of analytical procedures.
Trends in Analytical Chemistry 37, 6172.
38
IM PHT (PPS) TRONG TNH QUY M SINH THI

TC CHT
Lng
Ri ro (vt l, mi trng,
sc khe v ngh nghip)
im pht con
1
2
3
0
1
2
<10 mL (g)
10-100 mL (g)
>100 mL (g)
Khng
t ri ro
Ri ro
im pht tng
Amount
PPHazard
PP
THIT B
Nng lng
Ri ro ngh nghip
Cht thi
0.1 kWh / mu
1.5 kWh kWh / mu
>1.5 kWh kWh / mu
H thng phn tch kn
Thi hi v kh vo khng kh
Khng
<1 mL (g)
1-10 mL (g)
>10 mL (g)
Ti ch
Phn hy
Th ng ha
Khng x l
0
1
2
3
39
B MN HA PHN TCH
KHOA HA
I HC CNG NGH GDANSK
Department of
Analytical Chemistry
C th tm bi ging ny a ch
http://www.pg.gda.pl/chem/Katedry/Analityczna/analit.html
40
EUROPEAN MASTER IN QUALITY

IN ANALYTICAL LABORATORIES- EMQAL
http://eacea.ec.europa.eu/erasmus_mundus/
41
MODAS
Sn xut v chng thc cc vt liu mi quan trng c
bit cc phng th nghim ca Balan t chng
nhn ca chu u MODAS
http://www.pg.gda.pl/chem/modas/
42
43
43
MEMBERS OF MY RESEARCH GROUP
44
THANK YOU FOR YOUR ATTENTION!
45

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p dng k thut chun b mu xanh c lp,

lm giu v phn tch sc k cc nhim hu

of Physical Chemistry, Chemical Faculty

Analytica Vietnam , 17-19.04.2013, Ho Chi Minh City

VAI TR CA HA PHN TCH TRONG

Analytica Vietnam , 17-19.04.2013, Ho Chi Minh City

(LCH S PHT TRIN)

Vin HA HC XANH (EPA) ra i USA.

Nhm hot ng Ha hc xanh ca IUPAC

Hi ngh quc gia u tin v HA HC

Hi tho quc t u tin v HA HC

Chng trnh Ha hc xanh c US EPA

Gii thng hng nm cho cc thnh tu

C quan kim sot Cht c v ngn nga

Paul Anastas a ra thut ng HA HC

Analytica Vietnam , 17-19.04.2013, Ho Chi Minh City

11. Phn tch thi gian

12. Gim thiu nguy c

1. Trnh pht thi

HA PHN TCH XANH-GAC

THE COMPONENTS OF GREEN ANALYSIS

Gn nh, tn t nng lng

A. Gauszka, Z.M. Migaszewski, J. Namienik Twelve principles of green analytical chemistry

THE PRINCIPLES OF GAC EXPRESSED AS

Chn phng php trc tip

A KHI NIM PHT TRIN BN

HA PHN TCH XANH

Tm k thut phn tch mi

Cc tc ng gin tip ln cc cht

Tch hp v nhha thit b phn tch

CC MC NG NH TRONG HA PHN TCH XANH

Pht trin pp phn tch tim dng - FIA

Pht trin k thut gii - hp th (purge-and-trap) - PT

Pht trin pp. chit pha rn - SPE

Pht trin pp ly trch im sng (cloud point extraction CPE)

Pht trin pp ly trch bng vi sng (microwave-assisted extraction MAE)

Khi nim ha hc sinh thi (H. Malissa)

Pht trin pp vi chit pha rn (solid-phase microextraction SPME)

Pht trin pp chit p sut cao (presurized solvent extraction PSE)

Khi nim ha hc xanh (P.T. Anastas)

H2O Siu nng

tan ca cht c th thay i

Cht khng phn cc

Cc cht c th chit d dng

Cht khng phn cc

Hot tnh ca cht cn phn tch

Thp trung bnh

Lm giu sau ly trch

Ly trch chn lc cc cht vi

Khong bin thin phn cc

Analytica Vietnam , 17-19.04.2013, Ho Chi Minh City

Analytica Vietnam , 17-19.04.2013, Ho Chi Minh City

KHNG TiN X L TRC PHN TCH GiI PHP HON HO

Analytica Vietnam , 17-19.04.2013, Ho Chi Minh City

K THUT CHUN B MU KHNG DUNGMI

K thut chit pha rn

K thut chit bng

Phn tch Ha hi tnh (S-HS)

Headspace (Ha hi)