Non-potable drinking water

Pathogenic microorganism (Entamoeba histolytica) enters the system

Microorgansim releases endotoxins
Hyperstimulation/ irritation of intestinal lining
Disruption of cell membrane
Increased water and electrolyte secretion

Release of chemical mediators

Active secretion of Chloride and bicarbonate ions

Activation of nociceptors

Inhibition of Sodium and Water reabsorption

Nerve impulse sent to CNS

Increased Protein-rich fluid secretion

CNS response: Vasodialtion,

Increased cell permeability
Abdominal cramping/pain

Overwhelms large bowels ability to reabsorb fluids

Increased fluid volume and decreased intestinal motility

Abdominal distention

Watery stools (Diarrhea), Hyperactive bowel sounds Stimulation of vomiting center in the brain
Nausea, Anorexia

Continuous active fluid losses, Decreased food and fluid intake

Inadequate hydration and nutrition
Dry lips and mucous membranes, Sunken eyeballs, Poor skin turgor