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    Lecture 5 Sample Problem Answers

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    This document contains sample answers to problems from Lecture 5 of the BIOSC1000 course. It discusses potential locations of reverse turns or bends, intrachain disulfide linkages, and whether certain amino acids would likely be on the interior or exterior of a globular protein, based on an example amino acid sequence. It also states that hemoglobin, a protein made of two alpha and two beta subunits, exhibits all four levels of protein structure: primary, secondary, tertiary, and quaternary.

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    Lecture 5 Sample Problem Answers

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    sonicdragon
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    This document contains sample answers to problems from Lecture 5 of the BIOSC1000 course. It discusses potential locations of reverse turns or bends, intrachain disulfide linkages, and whether certain amino acids would likely be on the interior or exterior of a globular protein, based on an example amino acid sequence. It also states that hemoglobin, a protein made of two alpha and two beta subunits, exhibits all four levels of protein structure: primary, secondary, tertiary, and quaternary.

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    This document contains sample answers to problems from Lecture 5 of the BIOSC1000 course. It discusses potential locations of reverse turns or bends, intrachain disulfide linkages, and whether certain amino acids would likely be on the interior or exterior of a globular protein, based on an example amino acid sequence. It also states that hemoglobin, a protein made of two alpha and two beta subunits, exhibits all four levels of protein structure: primary, secondary, tertiary, and quaternary.

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    21 views1 page

    Lecture 5 Sample Problem Answers

    Uploaded by

    sonicdragon
    This document contains sample answers to problems from Lecture 5 of the BIOSC1000 course. It discusses potential locations of reverse turns or bends, intrachain disulfide linkages, and whether certain amino acids would likely be on the interior or exterior of a globular protein, based on an example amino acid sequence. It also states that hemoglobin, a protein made of two alpha and two beta subunits, exhibits all four levels of protein structure: primary, secondary, tertiary, and quaternary.

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    BIOSC1000

    Fall2012(2131)

    SampleProblemAnswersLecture5

    1. Considerthefollowingaminoacidsequence:

    IleAlaHisThrTyrGlyProPheGluAlaAlaMetCysLysTrpGluAlaGlnProAsp
    GlyMetGluCysAlaPheHisArg

    a. Wheremightreverseturnsorbendsoccur?

    Bendsorturnsaremostlikelytooccuratresidues7and19(Proresidues)
    becauseProisoften(butnotalways)foundatbendsinglobularfolded
    proteins.NotethatbendsoftenalsocontainGlyandthereareGlyresiduesvery
    closetoeachoftheProresiduesinthissequence.

    b. Wheremightintrachaindisulfidelinkagesform?

    IntrachaindisulfidebondscanonlyformbetweenCysresidues(residue13and
    24).

    c. Assumingthissequenceispartofalargerglobularprotein,wouldyouexpect
    thefollowingaminoacidstobeontheinteriororexterioroftheprotein?

    Asp,Ile,Thr,Gln,Lys

    Aminoacidswithionic(charged)orstronglypolarneutralgroups(Asp,Gln,
    andLysinthisprotein)arelocatedontheexternalsurface,wheretheyinteract
    withwater.Residueswithnonpolarsidechains(Ile)arelocatedintheinterior,
    awayfromthewater.ThrismostlikelyfoundontheexteriorbecausetheOH
    groupgivesithydrophylliccharacter,butitcouldalsobefoundintheinterior
    becauseitisunchargedatneutralpHandhasanextramethylgroupthatcould
    interactwithnonpolarresidues.

    2. Hemoglobinisaproteinthatconsistsof4subunits,2alphasubunitsand2beta
    subunits.Whatlevelsofproteinstructuredoeshemoglobinexhibit?

    Hemoglobinexhibitsallfourlevelsofproteinstructure(primary,secondary,tertiary,
    andquaternary).

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