CANCER

IARC Classification
Group 1
Group 2A
Group 2B
Group 3
Group 4

Sufficient evidence in humans or

sufficient evidence in animals and
strong mechanistic data in humans
Limited evidence in humans and
sufficient evidence in animals
Limited evidence in humans and less
than sufficient evidence in animals
Inadequate in humans and
inadequate or limited in animals
Lack of carcinogenicity in humans
and in animals

Acetaldehyde
Acrylonitrile
Aflatoxin
1-Aminonaphthalene

include
include

2-Aminonaphthalene
4-Aminobiphenyl
Arsenic
Benzene
Benzo[a]pyrene
1,3-Butadiene
Cadmium
Catechol
Chlorinated
dioxins/furans

include
include
include
include
include
include
include
include
Include -

Category on
IARC 2010 list
Group 2B
Group 2B

Yes in smokeless
NIOSH (2010) : potential
occupational carcinogen

include

Is there a
method of
measurement?

Not on IARC 2010 list;

On Following Lists

Group 1
Group 1
Group 1
Group 1
Group 1
Group 2A
Group 1
Group 2B
Group 2B

Chlorinated dioxins: NTP (11th

report): human carcinogen

CANCER (continued)
Category on
IARC 2010 list
Group 1

Chromium
Cresols

include
include

Crotonaldehyde

include

Formaldehyde
Hydroquinone
Isoprene
Lead
Mercury

include
include
include
include
include

N-nitrosoanabasine

include

N-nitrosodimethylamine
Nickel
4-(methylnitrosamino)1-(3-pyridyl)-1-butanone
N-nitrosonornicotine
N-nitrosopyrrolidine

include
include
include

Group 2A
Group 1
Group 1

include
include

Group 1
Group 2B

Not on IARC 2010 list;

On Following Lists
EPA (2010): o-cresol, m-cresol, pcresol: possible human carcinogens
EPA (2010): possible human
carcinogen

Group 1
None: possible tumor promoter
Group 2B
Group 2A

IARC 1993: methyl mercury:

possibly carcinogenic to humans
IARC (2007): limited evidence of
carcinogenicity in experimental
animals; no classifiable in humans
Yes in smokeless

Yes in smokeless

CANCER (continued)
Category on Not on IARC 2010 list;
IARC 2010 list On Following Lists

Phenol
Quinoline

DO NOT
INCLUDE

Tar

include

Styrene
3-Aminobiphenyl
N-nitrosoanatabine

include

include

EPA (2010): likely to be

carcinogenic in humans
Produces carcinoma when painted
on mouse skin
Group 2B

DO NOT
INCLUDE
DO NOT
INCLUDE

Shaded rows added during the 6/8/10 meeting

Polycyclic aromatic
hydrocarbons (PAH)
Benz[j]aceanthrylene
Benz[a]anthracene
Benz[b]fluoroanthene
Benz[j]fluoroanthene
Benz[k]fluoroanthene
Benzo[c]phenanthrene

propose to include all / representative

sample / include all for now, until we
discuss methods

On IARC List

Group 2B
Group 2B, smokeless
Group 2B, smokeless
Group 2B, smokeless
Group 2B, smokeless
Group 2B

CANCER (continued)
Chrysene
Cyclopenta[c,d]pyrene
Dibenz[a,h]anthracene
Dibenzo[a,e]pyrene
Dibenzo[a,i]pyrene
Dibenzo[a,h]pyrene
Dibenzo[a,l]pyrene
Indeno[1,2,3-cd]pyrene
5-Methylchrysene
Naphthalene
Aromatic Amines
2-Toluidine
2,6-Dimethylaniline
0-Anisidine

Group 2B, smokeless

Group 2A
Group 2, smokeless

Group 2B
Group 2B
Group 2B
Group 2A

Group 2B, smokeless

Group 2B
Group 2B, smokeless

Group 2A

Group 2B
Group 2B

CANCER (continued)
Heterocyclic aromatic amines
A--C
MeA- -C
IQ
Trp-P-1
Trp-P-2
Glu-P-1
Glu-P-2
PhlP

Include all?

Other heterocyclic compounds

Furan
Dibenz(a,h)acridine
Dibenz(a,j)acridine
Dibenzo(c,g)carbazole
Benzo(b)furan
Nitrohydrocarbons
Nitromethane
2-Nitropropane
Nitrobenzene

Include all

Group 2B
Group 2B
Group 2A

Group 2B
Group 2B
Group 2B
Group 2B
Group 2B

Group 2B
Group 2B
Group 2B
Group 2B
Group 2B
Include all

Group 2B
Group 2B
Group 2B

CANCER (continued)
Misc Organic cpds
Acetamide
Acrylamide
Acrylonitrile
Vinyl Chloride
Ethylene oxide
Propylene oxide
Urethane
Vinyl acetate

Include all

Metals
Beryllium
Cobalt
Hydrazine
Radio-isotope
Polonium-210

Include all additional

Pyridine?

(respiratory)

Group 2B
Group 2A

Group 2B
Group 1
Group 1
Group 2B
Group 2B
Group 2B

Group 1
Group 2B
Group 2B
Group 1

Non-Neoplastic Effects (respiratory, cardiovascular,

developmental)
IARC Classification
Group 1
Group 2A
Group 2B
Group 3
Group 4

Sufficient evidence in humans or

sufficient evidence in animals and
strong mechanistic data in humans
Limited evidence in humans and
sufficient evidence in animals
Limited evidence in humans and less
than sufficient evidence in animals
Inadequate in humans and
inadequate or limited in animals
Lack of carcinogenicity in humans
and in animals

Acetaldehyde
Acetone
Acrolein
Acrylonitrile
Ammonia
Arsenic
1,3-Butadiene
Benzene
Benzo[a]pyrene
Butyraldehyde
Cadmium
Carbon monoxide
Chromium
Cresols
Crotonaldehyde
Eugenol
Formaldehyde
Glycerol
Hydrogen cyanide

Included as carcinogen
Included as a respiratory toxicant
Included as a respiratory toxicant
Included as carcinogen
Included as a respiratory toxicant
Included as carcinogen
Included as carcinogen
Included as carcinogen
Included as carcinogen
Included as a respiratory toxicant
Included as carcinogen
Included as cardiovascular
toxicant
Included as carcinogen
Included as carcinogen
Included as carcinogen
Included as a respiratory toxicant
Included as carcinogen
DO NOT INCLUDE
Included as a respiratory toxicant

CA EPA developmental
toxicant

FOOTNOTE

Non-Neoplastic Effects (continued)

Isoprene
Lead
Methyl ethyl ketone
Nickel
Nicotine
Nitrate
Nitric oxide/nitrogen oxides
Phenol
Propionaldehyde
Propylene glycol
Pyridine
Resorcinol
Selenium
Sodium propionate
Sorbic acid
Toluene

Included as carcinogen
Included as carcinogen
Included as a respiratory toxicant
Included as carcinogen
Included for addictive,
reproductive, and cardiovascular
effects
DO NOT INCLUDE (FOR
SMOKE)
Included as a respiratory and
cardiovascular toxicant
Included as a respiratory and
cardiovascular toxicant
Included as a respiratory and
cardiovascular toxicant
DO NOT INCLUDE
Included as a respiratory toxicant
Included as a respiratory toxicant
Included as a respiratory toxicant
DO NOT INCLUDE
DO NOT INCLUDE
Included as a respiratory toxicant

Addictive

FOOTNOTE
Canada and Brazil

CA EPA developmental

toxicant

Triacetin
Triethylene glycol

DO NOT INCLUDE
DO NOT INCLUDE

FOOTNOTE

Note: Anabasine, anatabine, myosmine, nornicotine will be discussed at next meeting after NIDA presentation
Note: Committee deferred menthol to the ongoing TPSAC consideration