Male Reproductive System

Esther RD Sitorus

Histology Department
Medical Faculty

Introduction

REPRODUCTIVE SYSTEM
INCLUDES :
1.

2.

3.
4.
5.

TESTES-SPERM
PRODUCTION VIA MITOSIS
AND MEIOSIS
EPIDIDYMIS-STORAGE OF
SPERM
GENITAL DUCTS
PENIS
ACCESORY GLANDS-TO
SUPPORT & TRANSPORT
SPERM :

SEMINAL VESSICLE
PROSTATE
BULBOURETHRAL GLANDS

Ducts of the testis and the ductus

epididymis

Testes
VASCULATURE IS CRITICAL TO FUNCTION
SPERM PRODUCTION
ERECTION & TRANSMISSION OF SPERM
TEMPERATURE REGULATION-MUST BE BELOW 37C

CONNECTIVE TISSUE SYSTEM

TUNICA BAGINALIS (OUTER), T. ALBUGINEA (MIDDLE)
& T. VASCULOSA (INNER)
MEDIASTINUM TESTES = CONNECTIVE TISSUE TO
PROTECT BLOOD VESSELS, LYMPHATICS & GENITAL
DUCTS
LOBULES CONTAIN THE SEMINIFEROUS FOR SPERM
PRODUCTION
THESE LOBULES TERMINATE IN TUBULI RECTI TO
RETE TESTIS

Tubulus seminiferus
1.

2.

DIFFERENT SPERMATOGENIC CELLS ARE INTERSPERSED

WITH EPITHELIAL CELLS (SERTOLI) AT SPECIFICSITES
GOVERNED BY SPECIFIC INTERCELULAR CONNECTIONS
DEVELOPS IN CYCLES74 DAYS TO MATURATION
TUNICA PROPRIA CONTAINS MYOID CELLS WHICH ARE SMOOTH
MUSCLE LIKE AND USED FOR CONTRACTION OF PERISTALTIC TO
MOVE SPERM

3.

SERTOLI CELLS
TALL COLUMNAR EPITHELIUM
SUPPORT (NURSE) CELLS FOR SPERM
EXTENSIVE RER, GOLGI, LIPID, GLYCOGEN & INCLUSIONS
INDICATE HIGH METABOLIC ACTIVITY
SPECIFIC CELL-CELL INTERACTIONS IN UNIQUE TIGHT
JUNCTIONS
ALSO A CELL-SPERMATOCYTE JUNCTION=DESMOSOMAL LIKE

Tubulus seminiferus
4.

CELL-CELL ESTABLISHES THE BASAL AND LUMINAL

COMPARTMENTS
SPERMATOGONIA & PRIMARY SPERMATOCYTE CONFINED TO
BASAL LAYER BY TIGHT JUNCTION
WITH MEIOSIS & SPERMATOGENESIS MOVEMENT UPWORDS
TOWARDS THE LUMINAL SURFACE

5.
6.
7.

INDICATES NURSE CELL FUNCTION AS IN OTHER

SYSTEMS
BASAL LAMINAE DEFINES BLOOD-TESTES BARRIER &
BLOCKS CERTAIN MOLECULES SUCH AS Iggs BUT
OTHERS OK
LEYDIG CELLS

LARGE ACIDOPHILIC (HARD TO SEE) WITH INCLUSIONS OF

LIPID AND CRYSTALS OF REINKE
STEROID SECRETING PROFILE FOR TESTOSTERONE
IN OLD AGE MAY RESEMBLE FIBROBLASTS

Tubulus Seminiferus

SPERMATOGENESIS 3
PHASES
A.

SPERMATOGONIAL
1.
2.

3.

B.

STEM CELLS DIVIDE

COMMITTED POPULATION OF CELLS TO
BE SPERMATOGONIA
HISTOLOGICALLY DEFINED BY
APPEARANCE OF NUCLEI AND STAIN
AFFINITY

SPERMATOCYTE=MEIOSIS
1.

2.

REDUCTION DIVISION AFTER MITOSIS

TO NUCLEI
TIME OF CROSS OVER

C. SPERMATID = SPERMIOGENESIS
1.

AFTER 2nd MEIOTIC DIVISION GOES TO 4

PHASES
A.

B.

C.

GOLGI PHASE-PROACROSOMAL GRANULE TO

FORM ACROSOMAL VESICLE NEAR NUCLEAR
MEMBRANE; MOVEMENT OF CENTRIOLES
CAP PHASE-FORMATION OF ACROSOMAL CAP IN
TIGHT ASSOC. WITH MEMRANE
ACROSOMAL PHASE-REORIENTATION,
CONDENSATION OF NUCLEUS AND MT FOR
MACHETTE CYLINDER

D. MATURE SPERM
1.
2.
3.

4.
5.

HEAD AND TAIL REGION

ACROSOMAL REACTION-RECOGNITION AND
DIGESTION
SPERM ARE SECRETED IN FLUID FROM
SERTOLI CELLS AND ARE NON-MOTILE AT
THIS TIME
HIGH CONCENTRATION OF TESTOSTERONE
NECESSARY FOR MATURATION IN LUMEN
DUCTS OF TESTES
A.

B.

TUBULI RECTI=STRAIGHT TUBE TO RETE TESTES

OF MEDIASTINUM
SIMPLE EPITHELIUM WITH APICAL CILIA

Tubulus seminiferus

Males gametes

DUCTUS EPIDIDYMIS
1.
2.

3.

MATURATION OF SPERM
PSEUDOSTRATIFIED EPITHELIUM WITH
STEREO CILIA THAT CONTAINS
PRINCIPAL CELLS AND BASAL CELLS
FUNCTION
A.
B.

C.

FLUID RESORBTION
PHAGOCYTOSIS OF RESIDUAL BODIES FROM
SPERM
SECRETION OF GLYCOPROTEIN HIGH FRUCTOSERICH FLUID WITH GLYCERPHOSPHOCHOLINE,
SIALIC ACID AND GP

Ductus Epididymis

DUCTUS DEFERENS (VAS

DEFERENS)
1.
2.
3.
4.

5.

APPEARANCE OF SMOOTH MUSCLE

APICAL REGION NEAR EPIDIDYMIS
DISTAL AT PROSTATIC URETHRA
ENLARGES AT AMPULA, JOINTS THE DUCT
OF SEMINAL VESICLE TO THE
EJACULATORY DUCT
PSEUDOSTRATIFIED EPITHELIUM WITH
LOTS OF MUCOSAL INFOLDING

Ductus Defferens

ACCESSORY SEX GLANDS

A.

B.

ALL APICAL TO VAS DEFERENS TO

PRODUCE FLUID FOR METABOLISM AND
TRANSPORT OF SPERM
SHOOTING BLANKS MEANS TO PRODUCE
ALL THE SEMEN WITHOUT SPERM IF YOU
HAVE A VASECTOMY = TUBULE LIGATION

SEMINAL VESICLES
1.

2.

PAIRED TUBULAR GLANDS IN

MUSCULAR AND FIBROUS COAT
SECRETES VISCUS FLUID FOR
SPERM METABOLISM (FRUCTOSE),
AMINO ACID, ASCORBATE
(ANTIOXIDANT) AND
PROSTAGLANDINS

Seminal Vesicles

PROSTATE GLAND
A.
B.
C.
D.

LARGE TUBULO ALVEOLAR GLAND

PROXIMAL TO URETHRA
MUCOSAL LAYER
SUBMUCOSAL LAYERGLANDS
CANCER RISK-BENIGN HYPERTHROPHY

Prostate Gland

BULBOURETHRAL GLANDS
(COWPERS
GLANDS)

SIMPLE MUCUS SECRETING

SECRETES GALACTOSE,
GALACTOSAMINE & SIALIC ACID
MAJOR PORTION OF PRESEMINAL
FLUID
SEMEN=ALL PRODUCTS OF
SECRETION FOR LUBRICATION,
NUTRITION AND ENHANCEMENT OF
FERTILIZATION

PENIS
CARRIES BOTH URINE AND SPERM
ERECTILE TISSUE 2 DORSAL MASSES CORPORA
CAVERNOSA AND 1 VENTRAL CORPORA
SPONGIOSUM
CT= TUNICA ALBUGINEA
ERECTILE AND INCREASE PRESSURE
(CONSTRICTION) OF VENOUS SYSTEM
AUTONOMIC ACTIVITY CONTROLS BLOOD FLOW
INTO CORPORA CAVERNOSA AND AV SHUNT
(CONSTRICTION)

A.
B.

C.
D.
E.

1.
2.
3.

F.

PARASYMPATHETIC INITIATES THE ERECTION

SYMPATHETIC RESPONSIBLE FOR EJACULATION
COMMONLY TERMED POINT AND SHOOT

SOME CORTICAL CONTROL FANTASIES, STRESS

Transverse section of the penis