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    Iada A 821476 sm0001

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    benh
    Pseudoephedrine HCl Extraction Procedure and Analytical Method Procedure Grind Tablet samples in a grinder into a fine powder. Pour the resulting suspension into filter paper and gravity filter into a collection vessel. The solvent was removed from the filtrate by vacuum drying. The remaining solid was continually vacuum dried at room temperature overnight. The dried solid was stored refrigerated until analyzed by HPLC.

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    Iada A 821476 sm0001

    Uploaded by

    benh
    10 views1 page
    Pseudoephedrine HCl Extraction Procedure and Analytical Method Procedure Grind Tablet samples in a grinder into a fine powder. Pour the resulting suspension into filter paper and gravity filter into a collection vessel. The solvent was removed from the filtrate by vacuum drying. The remaining solid was continually vacuum dried at room temperature overnight. The dried solid was stored refrigerated until analyzed by HPLC.

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    Pseudoephedrine HCl Extraction Procedure and Analytical Method Procedure Grind Tablet samples in a grinder into a fine powder. Pour the resulting suspension into filter paper and gravity filter into a collection vessel. The solvent was removed from the filtrate by vacuum drying. The remaining solid was continually vacuum dried at room temperature overnight. The dried solid was stored refrigerated until analyzed by HPLC.

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    10 views1 page

    Iada A 821476 sm0001

    Uploaded by

    benh
    Pseudoephedrine HCl Extraction Procedure and Analytical Method Procedure Grind Tablet samples in a grinder into a fine powder. Pour the resulting suspension into filter paper and gravity filter into a collection vessel. The solvent was removed from the filtrate by vacuum drying. The remaining solid was continually vacuum dried at room temperature overnight. The dried solid was stored refrigerated until analyzed by HPLC.

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    Supplement1:PseudoephedrineHClExtractionProcedureandAnalyticalMethod

    Procedure
    1) GrindTabletsamplesinagrinderintoafinepowder.
    2) Transferthepowderofeachformulationtoanappropriatelysizedbeakerequippedwithmagnetic
    stirbar.
    3) Add750mLofthetestsolventtothebeakerandstir.
    4) Pourtheresultingsuspensionintofilterpaperandgravityfilterintoacollectionvessel.Thesolvent
    wasremovedfromthefiltratebyvacuumdrying.Theremainingsolidwascontinuallyvacuumdried
    atroomtemperatureovernight.
    5) ThedriedsolidwasstoredrefrigerateduntilanalyzedbyHPLC.
    Method
    HPLCChromatographicParametersusedinPseudoephedrineExtractionDetermination
    HPLCInstrument:Agilent1200
    Column:PhenomenexLunaPhenylHexyl,150x3.0mm,3.0m(USPcategoryL11column)
    MobilePhase:~0.035Mtriethylaminephosphoricacid(pH6.8):MeOH90:10
    FlowRate:0.6mL/min(P275bar)
    InjectionVolume:10L
    Detection:Diodearray;monitoringchannelat206nm
    Temperature:Ambient
    Runtime:20min

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