Professional Documents
Culture Documents
Thyroid Nodule
Thyroid Nodule
Thyroid Nodule
1)A32yearoldmalepresentswitha3cmleftthyroidnodule.Hereportscervicaldysphagia.TSHlevels
arenormal.USrevealsbenigncharacteristicsandnootherthyroidnodules.USguidedFNArevealsa
BethesdaCategoryIIbenignnodule.Whatisthenextmostappropriatestepinmanagement?
Subtotalthyroidectomy
Leftthyroidlobectomyandisthmusectomy
CTscanoftheneck
Refertoendocrinologyforradioactiveiodineablation
Referpatientbacktoprimarycareforroutinefollowup
Youransweriscorrect
Discussion:Thispatientpresentswithasymptomaticthyroidnodulecausingdysphagia.AlthoughhisFNA
revealsalowrisknoduleformalignancy(03%basedonBethesdacriteria),thenoduleisstillcausing
troubleswallowing.Inaeuthyroidsetting,radioactiveablationisnotindicated.CTscanoftheneckwould
notprovideanyadditionalinformationinthedecisionmakingprocess.Intheabsenceofmultinodular
goiter,aunilateralprocedureispreferred.
2)A48yearoldfemaleundergoesevaluationforhoarseness.Herworkuprevealsa4.2cmrightthyroid
nodule.SubsequentUSguidedFNArevealsaBethesdaCategoryVInodule,consistentwithpapillary
carcinoma.Whatisthenextmostappropriatestepinhermanagement?
MRIoftheneck
Nuclearmedicinethyroidscan
Laryngoscopy
Rightthyroidlobectomyandisthmusectomy
Totalthyroidectomy
Youranswerisnotcorrect
Discussion:Inpatientswiththyroidcancerwhopresentwithsignsofinvasionintoadjacentstructures,
laryngoscopyshouldbeperformedtoevaluatethefunctionofthevocalcordspreoperatively.Anuclear
medicinethyroidscanwouldnotchangemanagementatthispointinherevaluation,norwouldMRI.A
totalthyroidectomywouldbethedefinitiveprocedureofchoiceafterlaryngoscopytoevaluatehervocal
cords.Althoughlobectomyandisthmusectomyisanappropriatedefinitiveprocedureforsomethyroid
cancers,thispatient'sageandsizeoftumormakeitaninferioroperationinthissetting.
3)A50yearoldfemaleundergoesatotalthyroidectomyforpapillarythyroidcarcinoma.Tumorsizeis
3cmandtherewerenoinvolvedlymphnodes.Postoperativelysheundergoesradioactiveiodineremnant
ablation.Whichofthefollowingisappropriatelongtermfollowupcareforthyroidcancersurveillance?
AnnualTSHmeasurement
AnnualCTscanofthechest
AnnualI131scan
Annualthyroglobulinmeasurement
AnnualCTscanoftheneck
Youranswerisnotcorrect
Discussion:Thyroglobulinisonlyproducedbythyroidcellsandisanexcellentclinicalindicatorof
recurrence.InthesettingofTSHsuppression,aclimbingthyroglobulinlevelshouldpromptfurther
investigationofapossiblerecurrence.TSHlevelsshouldbemonitoredmorefrequentlythanannuallyto
maintainTSHsuppression.CTscansoftheneckorchestarenotindicatedforroutinesurveillance.I 131
scanningcanbeusefulforfurtherevaluationifarecurrenceissuspected.