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  • Sepsis: Vascular Resistance Venous Capacitance Vascular Leak

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    Annisa Safira Nurdila
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    Fluid resuscitation is important in treating sepsis to address relative hypovolemia caused by vascular leakage, which decreases stroke volume and cardiac output leading to tissue hypoxia. The key targets of fluid resuscitation are maintaining a central venous pressure of 8-12 mmHg with 500mL crystalloid IVs every 30 minutes, mean arterial pressure of at least 65 mmHg using vasopressors or vasodilators, SvO2 of at least 70% through blood transfusion or dobutamine, and urine output of 0.5 ml/kgBB/hour.

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    Fluid resuscitation is important in treating sepsis to address relative hypovolemia caused by vascular leakage, which decreases stroke volume and cardiac output leading to tissue hypoxia. The key targets of fluid resuscitation are maintaining a central venous pressure of 8-12 mmHg with 500mL crystalloid IVs every 30 minutes, mean arterial pressure of at least 65 mmHg using vasopressors or vasodilators, SvO2 of at least 70% through blood transfusion or dobutamine, and urine output of 0.5 ml/kgBB/hour.

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    11 views2 pages

    Sepsis: Vascular Resistance Venous Capacitance Vascular Leak

    Uploaded by

    Annisa Safira Nurdila
    Fluid resuscitation is important in treating sepsis to address relative hypovolemia caused by vascular leakage, which decreases stroke volume and cardiac output leading to tissue hypoxia. The key targets of fluid resuscitation are maintaining a central venous pressure of 8-12 mmHg with 500mL crystalloid IVs every 30 minutes, mean arterial pressure of at least 65 mmHg using vasopressors or vasodilators, SvO2 of at least 70% through blood transfusion or dobutamine, and urine output of 0.5 ml/kgBB/hour.

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    SEPSIS

    FLUID RESUSCITATION

    vascular resistance
    venous capacitance
    vascular leak

    RELATIVE HYPOVOLEMIA

    DECREASES IN STROKE VOLUME

    TISSUE HYPOXIA

    DECREASE IN CARDIAC OUTPUT

    ANAEROBIC METABOLISM

    LACTIC ACIDOSIS

    Central Venous Pressure :


    Administration of 500 mL of IV crystalloid every 30 minutes
    8 12 mmHg

    Mean Arterial Pressure :


    65 mmHg

    Vasopressors and vasodilators

    SvO2 :
    At least 70%

    Blood transfusion or dobutamine

    Targets of Fluid Resuscitation

    Urine Output :
    0,5 ml/kgBB/jam

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