Oktoberfest: impactul remarcabil al

genului si varstei asupra intoxicarii

cu etanol
Autori: C. Binner, S. Selinski, M. J. Barysch, H.M. Bolt, R. Lessing, H. Trauer, Claudia
Rudolph

Student: Bote Andreea Oana

Chimie si Inginerie Chimica,
sectia CATB, anul III
Cluj-Napoca, 2010
 Introducere
• Oktoberfest = festivalul berii din Germania
• Anual 6 milioane de vizitatori⥤5000 au
suportat tratament medical
• 405 internati intr-o tabara medicala
 Materiale si metode
• Ctriterii de excludere: -trauma
- lipsa intoxicarii cu alcool
- complicatii care cereau masuri de urgenta
• 8 posibili parametii de influienta : gen(F;M) ,
varsta, GCS, presiunea sangelui sistolica si
diastolica, temperatura, pulsul si conc de etanol
din sange
 Materiale si metode
• GCS=scala neurologica utilizata pt cuantificarea nivelului de
constiinta
1 2 3 4 5 6

Opens eyes
Does not in response
Opens eyes Opens eyes Afectiuni cerebrale:
Eyes in response spontaneou N/A N/A
open eyes to painful
to voice sly •Severe, GCS ≤ 8
stimuli
•Moderate, GCS 9 - 12
Incomprehe Utters Oriented,
Verbal
Makes no
nsible inappropriat
Confused,
converses N/A •Minore, GCS ≥ 13.
sounds disoriented
sounds e words normally

Abnormal
Extension to
flexion to Flexion /
painful Localizes
Makes no painful Withdrawal
Motor stimuli ( painful Obeys commands
movements stimuli ( to painful
decerebrate stimuli
response decorticate stimuli
response
)
)
 Materiale si metode
• Varstele :in prima analiza 3 grupe: 10-19, 20-29, si ⩾30 ani.
in a2a analiza 5 grupe : 10-19, 20-29, 30-39, 40-49, si
⩾50 ani.
• GCS >8 si ⩽8
• Presiune sistolica a sangelui : ⩽100 si >100 mmHg
• Presiunea diastolica :⩽50 sau > de 50 mmHg
• Temperatura: ⩽34,9 si >34.9 ℃
• Pulsul :⩽98 sau >98 batai/minut
• Concentratia de etanol din sange: <1 , 1-1.49, 1.5-1.99, 2-
2.49, ⩾2.5 g/L.
 Rezultate
• Parameter Median 25–75% percentiles
• Glasgow Coma Score (GCS)a
at admission to the camp 12.0 10.0–13.0b
at discharge from the camp 15.0 15.0–15.0c
• Blood pressure at admission (mmHg)a
Systolic 110.0 100.0–125.0
Diastolic 70.0 60.0–80.0
Mean 83.3 73.3–93.3
• Blood pressure at discharge (mmHg)a
Systolic 120.0 110.0–134.0
Diastolic 72.0 63.0–80.0
Mean 88.7 80.0–99.2
• Body temperature (°C)a b Minimum–maximum: 3–15
c Minimum–maximum: 7–15
At admission to the camp: 35.0 34.9–36.1
d Minimum–maximum: 14–82
At discharge from the camp 36.3 35.9–36.7
• Heart rate (beats per min)a
At admission to the camp: 84.0 72.0–98.0
At discharge from the camp: 76.0 67.0–90.0
• Blood sugar (mg/dl): 92.0 78–108
• Blood ethanol concentration (g/L) :2.09 1.61–2.50
• Age (years): 24 20–34d
• Observation period (time between admission and discharge) (h):
2 .42 2.17–2.78
 Rezultate
• Table 2 Logistic
Parameter Odds ratio (OR) 95% Confidence
interval of OR
• A. Explanatory factors accepted by the logistic regression model
• Glasgow Coma Score (·8 versus >8)a 3.92 1.93–7.96
• Gender (male versus female) 3.72 1.40–9.89
• Age (20–29 versus ·19 years) 3.00 1.16–7.81
• Age (20–29 versus ¸30 years) 2.42 1.10–5.32
• B. All other parameters analyzed were not regarded as explanatory by the model
• Heart rate (¸98 versus <98 beats)a
• Body temperature (·34.9 versus >34.9°C)a
• Diastolic blood pressure (·50 versus >50 mmHg)a
• Blood ethanol concentration (<1, 1–1.49, 1.5–1.9, 2–2.49, ¸2.5 g/L)a
• Systolic blood pressure (·100 versus >100 mmHg)a

a parametrii determinati la admiterea

in tabara medicala
 Discutii
• Varsta, genul si GCS sunt asociate cu
spitalizarea
• 22 pacienti cu GCS<6⥤6 spitalizati
• 8 pacienti cu GCS<4⥤4 spitalizati
• Concentraia de etanol din sange nu a fost
asociata cu gradul de spitalizare
 Concluzii
Barbatii cu varsta intre 20-29 de ani au un risc
mai mare de a fi internati in spitat, acest lucru se
datoreaza nu concentratie mai mari de etanol
din sange ,ci datorita faptului ca ignora limitele
critice individuale de intoxicatie cu etanol.
Nivelele de alcool din sange nu sunt un criteriu
pentru gradul de intoxicatie.
Factorii predictvi pentru spitalizare sunt: GCS,
genul si varsta.