®

The Krebs Cycle

Cellular Respiration

Cytosol Mitochondrion

Krebs
Glycolysis Acetyl
CoA
cycle
S CoA
C O
CH3
Acetyl CoA
CoA-SH

_
COO - COO
NADH+H +
O C CH2
_
CH2 HO C COO
NAD +
COO - 1 CH2
-
COO Oxaloacetate COO
_

HO CH
8
Citrate
CH2 2
COO - _
Malate COO
CH2
7 H2O
HC COO
_
_
COO HO CH
CH COO
_

HC Isocitrate
_
COO
3 CO 2
Fumarate _
_ COO NAD +
COO CoA-SH CH2 NADH+H +
_ CoA-SH
FADH 2 CH2 COO CH2
6 FAD CH2 CH2 CO 2 C O
_ _
COO CH2 COO
Succinate GDP+ Pi
C O NAD+ α- Ketoglutarate
GTP
5 S CoA NADH+H +

ADP
Succinyl CoA 4
ATP