Scribd Logo
Upload

Welcome to Scribd!

  • Zoladex

    Uploaded by

    kinko6
    11 views2 pages
    Zoladex (Goserelin Acetate) is a luteinizing hormone releasing hormone analogue used to treat prostate cancer, both metastatic and advanced non-metastatic forms, as well as breast cancer. It works by initially stimulating testosterone or estrogen release, then paradoxically decreasing these hormones through negative feedback in the pituitary gland. Common side effects are listed but specifics on dosage and administration are provided.

    Original Description:

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    DOC, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Zoladex (Goserelin Acetate) is a luteinizing hormone releasing hormone analogue used to treat prostate cancer, both metastatic and advanced non-metastatic forms, as well as breast cancer. It works by initially stimulating testosterone or estrogen release, then paradoxically decreasing these hormones through negative feedback in the pituitary gland. Common side effects are listed but specifics on dosage and administration are provided.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as doc, pdf, or txt
    11 views2 pages

    Zoladex

    Uploaded by

    kinko6
    Zoladex (Goserelin Acetate) is a luteinizing hormone releasing hormone analogue used to treat prostate cancer, both metastatic and advanced non-metastatic forms, as well as breast cancer. It works by initially stimulating testosterone or estrogen release, then paradoxically decreasing these hormones through negative feedback in the pituitary gland. Common side effects are listed but specifics on dosage and administration are provided.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as doc, pdf, or txt
    of 2

    Zoladex (Goserelin Acetate)

    in Prostate Cancer Patients


    Luteinizing hormone releasing hormone analogue (LHRHa)

    AKA gonadotropin releasing hormone super agonist

    oIndirectly stimulates an initial release of testosterone in males and estrogen in females


    by activating receptors in the pituitary gland

    oParadoxically, this leads to a decrease in these hormones due to the feedback loop

    Indications

    oProstate cancer, metastatic (palliative treatment)

    in addition to palliative radiation

    oProstate cancer, advanced non-metastatic (Stage B2, Stage C) treatment with an


    antiandrogen

    in addition to radiation therapy

    oBreast cancer, advanced palliation

    oEndometriosis

    Contraindications

    oPregnancy

    oHypersensitivity

    Adverse Reactions

    Dosage

    Administration

    References
    Lexi-Comp Drug Information Handbook. 18th Edition 2009-2010.
    Montgomery BSI, Borwell JP, Higgins DM. Does needle size matter? Patient experience of luteinising
    hormone-releasing hormone analogue injection. Prostate Cancer and Prostatic Diseases (2005) 8, 66–68.
    Thomson Clinical Xpert (Micromedex) [computer program]. Thomson Reuters 2010.
    Zoladex LA, Product Monograph. AstraZeneca 2009.
    http://www.astrazeneca.ca/documents/ProductPortfolio/ZOLADEX%20LA_PM_en.pdf. Accessed June
    2010.

    You might also like