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  • Pathophysio of Asthma

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    Predisposing environmental and genetic factors can activate T-lymphocytes and trigger an immune response. This leads to the production of immunoglobulin E (IgE) which attaches to mast cells. When an antigen combines with IgE, the mast cells degranulate and release inflammatory mediators, causing mucus hypersecretion, bronchoconstriction, narrowing of the airways, cough, increased workload of breathing, dyspnea, and chest pain.

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    Predisposing environmental and genetic factors can activate T-lymphocytes and trigger an immune response. This leads to the production of immunoglobulin E (IgE) which attaches to mast cells. When an antigen combines with IgE, the mast cells degranulate and release inflammatory mediators, causing mucus hypersecretion, bronchoconstriction, narrowing of the airways, cough, increased workload of breathing, dyspnea, and chest pain.

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    8 views1 page

    Pathophysio of Asthma

    Uploaded by

    coteng
    Predisposing environmental and genetic factors can activate T-lymphocytes and trigger an immune response. This leads to the production of immunoglobulin E (IgE) which attaches to mast cells. When an antigen combines with IgE, the mast cells degranulate and release inflammatory mediators, causing mucus hypersecretion, bronchoconstriction, narrowing of the airways, cough, increased workload of breathing, dyspnea, and chest pain.

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    PATHOPHYSIOLOGY

    PREDISPOSING FACTORS:

     ENVIRONMENTAL FACTORS (EXTRINSIC/ INTRINSIC)


    o AIR POLLUTANTS
    o PSYCHOLOGICAL STRESS
    o VIRAL RESPIRATORY INFECTION
     GENETIC FACTOR

    ACTIVATE T-LYMPHOCYTES

    Th 1 Th2

    CELL MEDIATED IMMUNITY TRIGGERS HUMORAL SYSTEM

    ANTIGEN COMBINES WITH IgE WHICH ATTACH

    TO MAST CELLS (DEGRANULATION)

    RELEASES CONTENT OF MAST CELL/ MEDIATOR OF INFLAMMATION

    STIMULATION OF MUCUS BRONCHOSPASM

    GLAND TO SECRETE MUCUS BROCHOCONSTRICTION

    HYPERSECRETION OF MUCUS NARROWING AIRWAYS

    COUGH INCREASE WORKLOAD OF BREATHING

    DOB CHEST PAIN

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