PATHOPHYSIOLOGY

PREDISPOSING FACTORS: NON-PREDISPOSING FACTORS:

-Immuno-compromised -24 y/o
-Environment -Male

Bile of a Aedes aegypti mosquito carrying

A virus

Virus goes into the circulation

Infects cells and generate cellular response

Initiates destruction of the platelet

Increase potential for hemorrhage

Stimulates intense inflammatory response

Release of exogenous pyrogens the body releases anti-inflammatory

Mediators (Histatin, Kinins)
Increase WBC (neutrophils and microphages)
Vascular response
Release of endogenous pyrogens
Redness and Heat
Reset of hypothalamic thermostat
Headache, vomiting, epistaxis
Abdominal pain, circulatory collapse
Shock
Fever

Muscle contract to produce

Additional heat

Shivering

Blood vessels construct

To prevent loss of body heat

Chills