BILIRUBIN PRODUCTION AND ELIMINATION

After 120 days the RBC

Cellular component of RBC
RBC (life span 120 days) become fragile and
will be released
prone for destruction

Heme will split into: Hemoglobin will split

into: Macrophages will phagocyte
 Iron it
 Biliverdin  Globins
 Heme
Globins was breakdown
into amino acids

The iron that comes from Biliverdin reduct into Bilirubin fat is transported
the Heme will go to the bilirubin (indirect, to the liver with the help of
bone marrow for new RBC unconjugated) fat albumin
production

Urobilirubin will excrete The bacteria will convert The liver enzyme will
with the feces and some conjugated bilirubin to convert unconjugated to
of it in the urine. urobilirubin. conjugated bilirubin .