volume 01

1 HISTORY OF QUANTITATIVE
STRUCTURE-ACTMTY
RELATIONSHIPS, 1
2 RECENT TRENDS IN
QUANTITATrVE STRUCTUREACTMTY
RELATIONSHIPS, 49
3 MOLECULAR, MODELING IN
DRUG DESIGN, 77
4 DRUG-TARGET BINDING
FORCES: ADVANCES IN FORCE
FIELD APPROACHES, 169
5 COMBINATORIAL LIBRARY
DESIGN, MOLECULAR
SIMILARITY, AND DIVERSITY
APPLICATIONS, 187
6 VIRTUAL SCREENING, 243
7 DOCKING AND SCORING
FUNCTIONS/VIRTUAL
SCREENING, 281
8 BIOINFORMATICS: ITS ROLE IN
DRUG DISCOVERY, 333
9 CHEMICAL INFORMATION
COMPUTING SYSTEMS IN
DRUG DISCOVERY, 357
10 STRUCTURE-BASED DRUG
DESIGN, 417
11 X-RAY CRYSTALLOGRAPHY IN
DRUG DISCOVERY, 471
12 NMR AND DRUG DISCOVERY,
507
13 MASS SPECTROMETRY AND
DRUG DISCOVERY, 583
14 ELECTRON CRYOMICROSCOPY
OF BIOLOGICAL
MACROMOLECULES, 611
15 PEPTIDOMIMETICS FOR DRUG
DESIGN, 633
16 ANALOG DESIGN, 687
17 APPROACHES TO THE
RATIONAL DESIGN OF
ENZYME INHIBITORS, 715
18 CHIRALITY AND BIOLOGICAL
ACTIVITY, 781
19 STRUCTURAL CONCEPTS IN
THE PREDICTION OF THE
TOXICITY OF THERAPEUTICAL
AGENTS, 827
20 NATURAL PRODUCTS AS
LEADS FOR NEW
PHARMACEUTICALS, 847
INDEX, 901

volume 02
1 COMBINATORIAL CHEMISTRY
SYNTHESIS, 1
AND MULTIPLE PARALLEL
2 HIGH-THROUGHPUT
SCREENING FOR LEAD
DISCOVERY, 37
3 HIGH-THROUGHPUT
PHARMACOLOGY, 71
4 APPLICATION OF
RECOMBINANT DNA
TECHNOLOGY IN MEDICINAL
CHEMISTRY AND DRUG
DISCOVERY, 81
5 OLIGONUCLEOTIDE
THERAPEUTICS, 115
6 THERAPEUTIC AGENTS
ACTING ON RNA TARGETS, 167
7 CARBOHYDRATE-BASED
THERAPEUTICS, 203
8 MEMBRANE TRANSPORT
PROTEINS AND DRUG
TRANSPORT, 249
9 ALLOSTERIC PROTEINS AND
DRUG DISCOVERY, 295
10 RECEPTOR TARGETS IN DRUG
DISCOVERY AND
DEVELOPMENT, 319
11 NICOTINIC ACETYLCHOLINE
RECEPTORS, 357
12 LARGE-SCALE SYNTHESIS, 407
13 PRINCIPLES OF DRUG
METABOLISM, 431
14 METABOLIC CONSIDERATIONS
IN PRODRUG DESIGN, 499
15 RETROMETABOLISM-BASED
DRUG DESIGN AND
TARGETING, 533
16 DRUG DISCOVERY: THE ROLE
OF TOXICOLOGY, 609
17 DRUG ABSORPTION,
DISTRIBUTION, AND
ELIMINATION, 633
18 PHYSICOCHEMICAL
CHARACTERIZATION AND
PRINCIPLES OF ORAL DOSAGE
FORM SELECTION, 649
19 THE FDA AND REGULATORY
ISSUES, 683
20 INTELLECTUAL PROPERTY IN
DRUG DISCOVERY AND
BIOTECHNOLOGY, 703
INDEX, 783

volume 03
1 CARDIAC DRUGS:
ANTIANGINAL, VASODILATORS,
ANTIARRHYTHMIC, 1
2 DIURETIC AND URICOSURIC
AGENTS, 55
3 MYOCARDIAL INFARCTION
AGENTS, 155
4 ENDOGENOUS VASOACTIVE
PEPTIDES, 193
5 HEMATOPOIETIC AGENTS, 251
6 ANTICOAGULANTS,
ANTITHROMBOTICS, AND
HEMOSTATICS, 283
7 ANTIHYPERLIPIDEMIC
AGENTS, 339
OXYGEN DELIVERY BY
ALLOSTERIC EFFECTORS OF
HEMOGLOBIN, BLOOD
SUBSTITUTES, AND PLASMA
EXPANDERS, 385
9 INHIBITION OF SICKLE
HEMOGLOBIN
POLYMERIZATION AS A BASIS
FOR THERAPEUTIC APPROACH
TO SICKLE-CELL ANEMIA, 443
10 IRON CHELATORS AND
THERAPEUTIC USES, 479
11 THYROID HORMONES AND
THYROMIMETICS, 563
12 FUNDAMENTALS OF STEROID
CHEMISTRY AND
BIOCHEMISTRY, 593
13 FEMALE SEX HORMONES,
CONTRACEPTIWS, AND
FERTILITY DRUGS, 629
14 MALE SEX HORMONES,
ANALOGS, AND ANTAGONISTS,
679
15 ANTI-INFLAMMATORY
STEROIDS, 747
INDEX, 881

volume 04
1 INSULIN AND HYPOGLYCEMIC
AGENTS, 1
2 PEPTIDE AND PROTEIN
HORMONES, PEPTIDE
NEUROTRANSMITTERS, AND
THERAPEUTIC AGENTS, 45
3 INHIBITORS OF GASTRIC ACID
SECRETION, 85
4 CHEMOKINE AND CYTOKINE
MODULATORS, 129
5 COX-2 INHIBITORS AND
LEUKOTRIENE MODULATORS,
203
6 AGENTS ACTING ON
PROSTANOID RECEPTORS, 265
7 RETINOIDS, 317
8 VITAMINS, 359
9 LIFESTYLE AND OVER-THECOUNTER
DRUGS, 421
10 RADIOPAQUES, 483
11 MICROARRAYS AND GENE
EXPRESSION PROFILING
APPLIED TO DRUG RESEARCH,
599
12 SNPS: SINGLE NUCLEOTIDE
POLYMORPHISMS AND
PHARMACOGENOMICSINDlVIDUALLY
DESIGNED
DRUG THERAPY, 617
13 PLASMID DNA-MEDIATED
GENE THERAPY, 651
INDEX, 679

volume 05
1 MOLECULAR BIOLOGY OF
CANCER, 1
2 SYNTHETIC DNA-TARGETED
CHEMOTHERAPEUTIC AGENTS
AND RELATED TUMORACTIVATED
PRODRUGS, 51
3 ANTITUMOR NATURAL
PRODUCTS, 107
4 RADIOSENSITIZERS AND
RADIOPROTECTll% AGENTS, 151
5 SYNTHETIC ANTIANGIOGENIC
AGENTS, 215
6 FUTURE STRATEGIES IN
IMMUNOTHERAPY, 223
7 SELECTIVE TOXICITY, 249
8 DRUG RESISTANCE IN CANCER
CHEMOTHERAPY, 281
9 ANTIVIRAL AGENTS, DNA, 293
10 ANTIVIRAL AGENTS, RNA
11 RATIONALE OF DESIGN OF
ANTI-HIV DRUGS, 457
12 ORGAN TRANSPLANT DRUGS,
485
13 SYNTHETIC ANTIBACTERIAL
AGENTS, 537
14 P-LACTAM ANTIBIOTICS, 607
15 TETRACYCLINE,
AMINOGLYCOSIDE, MACROLIDE,
AND MISCELLANEOUS
ANTIBIOTICS, 737
16 ANTIMYCOBACTERIAL
AGENTS, 807
17 ANTIFUNGAL AGENTS, 881
18 ANTIMALARIAL AGENTS, 919
Dee Ann Casteel
19 ANTIPROTOZOAL AGENTS,
1033
20 ANTHELMINTICS, 1089
INDEX, 1097

volume 06
1 ADRENERGICS AND
ADRENERGIC-BLOCKING
AGENTS, 1
2 CHOLINERGICS, 39
3 ANTICHOLINERGIC DRUGS, 109
4 CNS STIMULANTS, 167
5 SEDATIVE-HYPNOTICS, 201
6 ANTICONVULSANTS, 263
7 NARCOTIC ANALGESICS, 329
8 ANTIDEPRESSANTS, 483
10 ANTIPSYCHOTIC AGENTS, 599
11 INVESTIGATIVE AGENTS FOR
USE IN NEURODEGENERATIVE
CONDITIONS, 673
12 THERAPEUTIC AND
DIAGNOSTIC AGENTS FOR
PARKINSON'S DISEASE, 711

13 ALZHEIMER'S DISEASE:
SEARCH FOR THERAPEUTICS,
743
14 COGNITION ENHANCERS, 779
15 DRUGS TO TREAT EATING
AND BODY WEIGHT
DISORDERS, 837

INDEX, 895
CUMULATIVE INDEX, 923