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Neurotransmitters
Neurotransmitters
So far, researchers have discovered about 15–20 different neurotransmitters, and new ones are still being identified.
The nervous system communicates accurately because there are so many neurotransmitters and because
neurotransmitters work only at matching receptor sites. Different neurotransmitters do different things.
Agonists and Antagonists
Deficiency is
Excess is
Neurotransmitter Major functions associated Agonists are chemicals that mimic
associated with
with the action of a particular
neurotransmitter. They bind to
receptors and generate postsynaptic
Muscle movement, attention, Alzheimer’s
Acetylcholine potentials.
arousal, memory, emotion disease
Nicotine and Receptors
Nicotine is an acetylcholine agonist,
Voluntary movement, learning,
Dopamine Schizophrenia Parkinsonism which means that it mimics
memory, emotion
acetylcholine closely enough to
compete for acetylcholine receptors.
Sleep, wakefulness, appetite, When both nicotine and
mood, aggression, impulsivity, acetylcholine attach to a receptor
Serotonin sensory perception, Depression site, the nerve fibers become highly
stimulated, producing a feeling of
temperature regulation, pain
suppression alertness and elation.
Antagonists are chemicals that
block the action of a particular
Endorphins Pain relief, pleasure
neurotransmitter. They bind to
receptors but can’t produce
Learning, memory, dreaming, postsynaptic potentials. Because
awakening, emotion, stress- they occupy the receptor site, they
Norepinephrine related increase in heart rate, Depression prevent neurotransmitters from
stress-related slowing of acting.
digestive processes Paralysis and Poison Arrows
Curare is a drug that causes
paralysis. As an acetylcholine
Main inhibitory neurotransmitter
GABA antagonist, it binds to acetylcholine
in the brain
receptors at nerve-muscle junctions,
preventing communication between
Main excitatory Multiple nerves and muscles. Doctors
Glutamate
neurotransmitter in the brain sclerosis sometimes use curare to immobilize
patients during extremely delicate
surgery. South American tribes have
long used curare as an arrow poison.