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  • Pathophisiology of Dengue

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    fortuneaya
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    The document outlines the pathophysiology of dengue fever. It describes how a person's initial infection with one dengue virus subtype leads to the production of antibodies against only that subtype. Upon infection by a different dengue virus subtype, those antibodies can bind but fail to inactivate the virus, potentially triggering more severe symptoms like hemorrhage, thrombocytopenia, and high fever. The viral infection causes lesions in blood vessels and the release of chemicals that increase vascular permeability and lead to fluid accumulation.

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    The document outlines the pathophysiology of dengue fever. It describes how a person's initial infection with one dengue virus subtype leads to the production of antibodies against only that subtype. Upon infection by a different dengue virus subtype, those antibodies can bind but fail to inactivate the virus, potentially triggering more severe symptoms like hemorrhage, thrombocytopenia, and high fever. The viral infection causes lesions in blood vessels and the release of chemicals that increase vascular permeability and lead to fluid accumulation.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as doc, pdf, or txt
    63 views2 pages

    Pathophisiology of Dengue

    Uploaded by

    fortuneaya
    The document outlines the pathophysiology of dengue fever. It describes how a person's initial infection with one dengue virus subtype leads to the production of antibodies against only that subtype. Upon infection by a different dengue virus subtype, those antibodies can bind but fail to inactivate the virus, potentially triggering more severe symptoms like hemorrhage, thrombocytopenia, and high fever. The viral infection causes lesions in blood vessels and the release of chemicals that increase vascular permeability and lead to fluid accumulation.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as doc, pdf, or txt
    of 2

    Predisposing factor Precipitating factor

    Environment (cleanliness, Location (tropical)


    sanitation)
    Age

    Bite from aedes aegypti mosquito

    Exposure to dengue virus subtype

    Immune system creates antibodies


    against this specific subtype

    Inability to bind to target cells

    Bite from another infected mosquito

    Infection to another dengue subtype

    Exposure to another dengue virus subtype

    Antibodies from the last infection bind to


    it but does not inactivate the virus

    Infection attracts macrophages

    Virus enters the macrophage


    and replicates in the cells
    Viral infection

    Creates multiply lesion in the blood stream Release of Release of prostaglandin


    Interleukin 1

    Release of bradykinin
    ↑ capillary ↑ ↑ vascular Reach the
    fragility consumptio permeabili anterior
    hypothalamus

    Myalgia
    Hemorrhagic Pleural effusion Athralgia
    manifestation High grade fever with
    (petechiae, headache
    purpura, Thrombocytopen
    epistaxis) ia

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