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  • Pa Tho Physiology of Dka

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    Elex Kim
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    Diabetic ketoacidosis occurs when there is a decrease in glucose utilization due to lack of insulin. This leads to gluconeogenesis and breakdown of protein and fat for energy. Increased ketone production and decreased pH due to ketosis can result in nausea, vomiting, altered consciousness, and life-threatening complications affecting fluid and electrolyte balance, organ function, and cardiac and respiratory function if not properly treated.

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    Diabetic ketoacidosis occurs when there is a decrease in glucose utilization due to lack of insulin. This leads to gluconeogenesis and breakdown of protein and fat for energy. Increased ketone production and decreased pH due to ketosis can result in nausea, vomiting, altered consciousness, and life-threatening complications affecting fluid and electrolyte balance, organ function, and cardiac and respiratory function if not properly treated.

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    22 views1 page

    Pa Tho Physiology of Dka

    Uploaded by

    Elex Kim
    Diabetic ketoacidosis occurs when there is a decrease in glucose utilization due to lack of insulin. This leads to gluconeogenesis and breakdown of protein and fat for energy. Increased ketone production and decreased pH due to ketosis can result in nausea, vomiting, altered consciousness, and life-threatening complications affecting fluid and electrolyte balance, organ function, and cardiac and respiratory function if not properly treated.

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    PATHOPHYSIOLOGY OF DIABETIC KETO ACIDOSIS

    Decrease Glucose Utilization

    Glucose Utilization Gluconeogenesis Breakdown of muscle Lipolysis of adipose


    protein and amino acids tissue

    Plasma Amino Acids Plasma free fatty


    Hyperglycemia
    acids

    Hyperosmolarity Gluconeogenesis
    Glycosuria FFA Oxidation

    pH

    Polyuria
    Loss of cellular
    potassium
    Ketosis
    Altered level of
    Osmotic Diuresis
    consciousness

    Plasma Potassium
    Nausea and
    Circulating Volume Potassium Excretion
    Vomiting

    Organ Perfusion Metabolic Acidosis

    Renal Function Cellular Potassium

    Cardiac Arrhythmias Kussmaul’s Respiration

    Hypotension
    Diabetic Coma
    Tachycardia

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