Isoprenaline

Generic

Adrenergic Beta 1 and Beta 2 antagonist, Antiasthmatic, Cardiac stimulant

Mechanism of action

Isoprenaline exerts action by non selective beta 2 adrenergic antagonist causing cardiac
stimulant, bronchodilatation and peripheral vasodilatation. By acting on beta 1 adrenergic
receptor, it produces positive chronotrophic and inotrophic effects which increase cardiac
output, in AV block it shortens conduction time and refractory period of the AV block
and increases the heart rate and strength of the ventricular contractions. By its direct
action on beta 2 adrenergic receptor it relaxes bronchial smooth muscles and reduces
residual volume and increases the vital capacity and enhances the removal of secretion.

Pharmacokinetics

Absorption – readily absorbed after parental and oral administration

Distribution – widely all over body
Metabolism – conjunction by gastrointestinal tract, enzymatic reduction in liver, lungs
and other tissues
Excretion – in urine as metabolites and as unchanged drug

Onset and duration of action

Few minutes and may last upto 2 to 6 hours

Indications

Bradycardia
Bronchospasm
Heart block
Shock

Dosage

2 to 4 mcg /body weight/hr or 0.5 to 10 mcg/ minute as infusion titrate according to

desired action
Adverse action

Fluctuations in BP
Tachycardia
Palpitations
Headache
Dizziness
Nervousness
Restlessness
Tremor
Anginal pain
Stokes Adam attack
Arrhythmias
Arrest
Diaphoresis
Heart burn

Contra indications

Hypersensitivity to the drug

Tachycardia
Arrhythmias - except responding
Angina
VF
CAD
Hyperthyroid
Recent MI
Pregnancy

Special precautions

Hypertension
Renal impairment
CAD/IHD
DM
AV node disease
Sensitive to sympathomimetic amines
Old age
Breast feeding
Children

Storage

Room temperature