Антиконвулсивни лекарствени продукти

(Антиепилептици)

1. Барбитурати :
 Phenobarbital*
H
O N O
5-ethyl-5-phenylbarbituric acid
H 3C NH

2. Барбитурови аналози :
 Primidone (Hexamidin)
H
O N

5-phenyl-5-ethylhexahydropyrimidine-4,6-dione
NH

O
H3C

3. Производни на хидантоина :
 Phenytoine* (Diphenin)

4. Производни на сукцинимида :
 Ethosuximide
H
N 3-methyl-3-ethylpyrrolidine-2,5-dione
O O

CH 3
H3 C

 Morsuximide (Morfolep)

1
5. 1,4-бензодиазепинови производни :
 Clonazepam (RIVOTRIL®)
O
HN
5-(2-Chlorophenyl)-1,3-dihydro-7-nitro-2 H- 1,4-
benzodiazepin-2-one

O2N
Cl

 Diazepam*
H3C O
N 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-
benzodiazepin-2-one

Cl

6. С друг строеж :
 Carbamazepine (TEGRETOL®, Stazepin)

5 H-Dibenz[b,f]azepine-5-carboxamide

O NH 2

2
  Valproic acid
H C
3
OH 2-Propylpentanoic acid или 2-propylvaleric
acid

H C
3

 Topiramate (Topimax)
O O
O
S
O NH 2
O O

H3C O O CH 3
H3C CH 3
2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

 Gabapentin
H2N COOH
1-(Aminomethyl)cyclohexaneacetic acid

7. Lamotrigine (Lamictal)
Cl
6-(2,3-Dichlorophenyl)-1,2,4-triazine-
Cl 3,5-diamine

N
N

H2N N NH 2

3
Антипаркинсонови лекарствени продукти

1. Централни холинолитици :
 Trihexylphenidil (PARKISAN®)

 Tolperisone
O

CH 3
H3C
2-Methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone

 Benzetimide (Tremblex)
H
O N O

3-Phenyl-1`-(phenylmethyl)-[3,4prime-bipiperidine]-2,6-dione

 Triperiden (Norakin)

 Biperiden (AKINETON®)
α-Bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-
1-piperidinepropanol

OH

4
 2. Допаминергични лекарствени продукти :
 Selegiline (JUMEX®)
CH 3 N,α-Dimethyl-N-2-propynylbenzene
ethanamine
CH
N
H 3C


Amantadine – сулфатът се продава като PK-Merz®
NH 2

Tricyclo[3.3.1.1 3,7 ]decan-1-amine или 1-adamantanamine


Ropinirole
H
N
O

H3C

N
H3C
4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one

Sinemet (Levodopa + Carbidopa)
O
3-Hydroxy-L-tyrosine
HO
OH

NH 2
HO
Levodopa
S-α-Hydrazino-3,4-
HO COOH dihydroxy-α-ethyl-
• H2 O benzenepropanoic
acid monohydrate
H3C HN NH 2
HO
Carbid
opa