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  • Pa Tho Physiology Client DM

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    Marty Martinez
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    This document summarizes the pathophysiology of diabetes mellitus in a 49-year-old female with a family history of the disease. It outlines modifiable risk factors like diet and lifestyle as well as non-modifiable factors like age, genetics, and sex. The pathophysiology involves uncontrolled lipolysis in adipose tissue leading to high free fatty acids, suppression of glucose metabolism, and impaired insulin action. This results in elevated blood glucose, glycosuria, dehydration, and increased appetite and thirst.

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    Pa Tho Physiology Client Dm

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    This document summarizes the pathophysiology of diabetes mellitus in a 49-year-old female with a family history of the disease. It outlines modifiable risk factors like diet and lifestyle as well as non-modifiable factors like age, genetics, and sex. The pathophysiology involves uncontrolled lipolysis in adipose tissue leading to high free fatty acids, suppression of glucose metabolism, and impaired insulin action. This results in elevated blood glucose, glycosuria, dehydration, and increased appetite and thirst.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as docx, pdf, or txt
    10 views1 page

    Pa Tho Physiology Client DM

    Uploaded by

    Marty Martinez
    This document summarizes the pathophysiology of diabetes mellitus in a 49-year-old female with a family history of the disease. It outlines modifiable risk factors like diet and lifestyle as well as non-modifiable factors like age, genetics, and sex. The pathophysiology involves uncontrolled lipolysis in adipose tissue leading to high free fatty acids, suppression of glucose metabolism, and impaired insulin action. This results in elevated blood glucose, glycosuria, dehydration, and increased appetite and thirst.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as docx, pdf, or txt
    of 1

    III.

    PATHOPHYSIOLOGY
    Client Based:

    Modifiable factor Non-modifiable factor


    -Diet (sweet foods) -Age (49 y/o)
    - Sedentary lifestyle -Genetics (Maternal)
    -Sex (Female)

    Uncontrolled Autoimmune destruction


    lipolysis in adipose of pancreatic B-cells
    tissue

    Increase level of Deficiency in insulin


    free fatty occurs in secretion
    plasma
    Abnormal pancreatic a-
    Suppress glucose cells function
    metab. In skeletal
    muscle
    Desensitization of the
    liber to the levels of blood
    Impairs the action glucose
    of insulin

    Excessive secretion of
    glucagon

    Decrease the expression


    of a number of genes
    necessary for target
    tissues to respond to
    insulin
    Elevated plasma
    glucose

    Capacity of kidney
    to absorb glucose
    is surpassed

    glycosuria Increased renal loss Accompanied of loss polyuria


    of glucose of H2O and
    electrolytes
    Negative calorie
    balance
    dehydration

    Increase appetite
    and food intake Activation of thirst
    mechanism

    polyphagia
    polydipsia

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