April 2006 Chap 5 (NLN-SMKLBB) 1

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April 2006 Chap 5 (NLN-SMKLBB) 1

Cancer – an effect of uncontrolled mitosis


• Cells which divide mitotically in an uncontrolled manner
can result in the growth of cell masses called tumors.
• Tumor cells may
– a. remain localised & be benign (non-cancerous), or
– b. break away & be malignant (cancerous). They are
carried to other parts of the body where they start
similar new tumors.
• Cells become cancerous due to damaged DNA.
• Cancer cells have an abnormal cell cycle, live longer
than normal cells & divide to produce more cancer cells.
• Cancer cells also have higher metabolic rates compared
to normal cells.
April 2006 Chap 5 (NLN-SMKLBB) 2
Well-formed oval-shaped Highly disorganized cancer
glands, evenly lined with a cells stacked upon each other
single, organized layer of cells in an apparently random
indicated by arrows fashion.
April 2006 Chap 5 (NLN-SMKLBB) 3
Colon cancer

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Cancers related to tobacco smoking

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Lung cancer

April 2006 Chap 5 (NLN-SMKLBB) 6


Mouth cancer

Mouth cancer related


to tobacco smoking.

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Different types of skin cancers

April 2006 Chap 5 (NLN-SMKLBB) 8


Cancer Treatments
• Surgical removal of cancerous tissues / organs.
• Radiotherapy: Radioactive rays are aimed at malignant
tumours to kill off cancer cells.
• Chemotherapy: Cytotoxic chemicals are injected into the
blood to be carried to malignant tumours. Cancer cells
will absorb higher dosages of these chemicals due to
their higher metabolic rates and are more likely to be
killed. Although dosages are carefully calculated to
minimise poisoning of non-cancerous cells, some normal
cells are inevitably killed as well – the cause of many of
the unpleasant side effects of chemotherapy.

April 2006 Chap 5 (NLN-SMKLBB) 9

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