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  • Repair and Transcription: Collision or Collusion ?

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    Shveta Jaishankar Iyer
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    The document discusses nucleotide excision repair and its relationship to transcription. It notes that the TFIIH subunits are involved in both repair and transcription processes. Defects in the repair mechanism can cause hereditary disorders like xeroderma pigmentosum and trichothiodystrophy. While repair and transcription were thought to be separate processes, evidence now suggests they can exchange roles depending on cellular needs. Maintaining genome integrity through preventing apoptosis, cancer and mutation accumulation is important. Further studies are still needed to better understand these processes at a molecular level and develop new therapies.

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    Repair and Transcription

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    The document discusses nucleotide excision repair and its relationship to transcription. It notes that the TFIIH subunits are involved in both repair and transcription processes. Defects in the repair mechanism can cause hereditary disorders like xeroderma pigmentosum and trichothiodystrophy. While repair and transcription were thought to be separate processes, evidence now suggests they can exchange roles depending on cellular needs. Maintaining genome integrity through preventing apoptosis, cancer and mutation accumulation is important. Further studies are still needed to better understand these processes at a molecular level and develop new therapies.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
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    Download as pptx, pdf, or txt
    28 views7 pages

    Repair and Transcription: Collision or Collusion ?

    Uploaded by

    Shveta Jaishankar Iyer
    The document discusses nucleotide excision repair and its relationship to transcription. It notes that the TFIIH subunits are involved in both repair and transcription processes. Defects in the repair mechanism can cause hereditary disorders like xeroderma pigmentosum and trichothiodystrophy. While repair and transcription were thought to be separate processes, evidence now suggests they can exchange roles depending on cellular needs. Maintaining genome integrity through preventing apoptosis, cancer and mutation accumulation is important. Further studies are still needed to better understand these processes at a molecular level and develop new therapies.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pptx, pdf, or txt
    of 7

    Repair

    and
    Transcription
    Collision or Collusion ?
    Shveta Jaishankar
    Int PhD.
    JNCASR
    Nucleotide Excision Repair
    TFIIH subunits
    Hereditary Disorders due to defective repair mechanism

    Xeroderma pigmentosum Trichothiodystrophy

    •High Photosensitivity •Ichthyosis


    •Skin malignancies •Progeria like features
    •Basal and squamous cell •Growth and mental
    Cockayne syndrome retardation
    carcinoma
    •Growth failure •Brittle hair and nails
    •Impaired nervous system
    •Photosensitivity
    •Premature aging
    Conclusion and Future aspects
    • Agreement between DNA • In depth molecular studies of
    repair and transcription processes for better
    understanding
    • Exchange of site of action
    • Relating 3D Genome
    depending upon organization with transcription
    requirement. and repair
    • Important factors- TFIIH, • DNA Repair studies on
    TFIIE,E2F1, NusA etc Hutchinson-Gilford
    • Genome integrity syndrome,Distal myopathies etc
    • Development of effective
    maintained by preventing
    therapies to many human
    apoptosis, cancer, mutation health problems
    accumulation
    Thank You
    Thank You

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