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Modifiedpatho Toyoda
Modifiedpatho Toyoda
Modifiedpatho Toyoda
Precipitating Factors:
• Hormonal Influences
ETIOLOGY: o early menarche
Unknown o nulliparity
o childbirth after 30
Predisposing Factors: years of age
• Age o late menopause
• Genetic o birth control pills
Predisposition • Medical History of
• Sex - Females abnormal breast biopsies
• Lifestyle
Failure of immune
surveillance
DNA damage
Mutation in cell
genes
Unregulated
breast cell growth
and differentiation
Overgrowth of
breast tissue
Neoplasm formation in
the breast
Abnormal growth
signaling interaction
between tumor cells
and stromal cells
Medical Management:
(For symptomatic relief only)
o Diet Changes: Low
fat, increase intake of Intermediate
fruits and vegetables, features
o Wearing good support
bra Clinical
manifestations:
Surgical Management:
Borderline Phyllodes
Lumpectomy larger mass Breast Tumor
Mastetcomy
Excision Biopsy
Stromal hypercellularity
Removal of the
tumor
GOOD
PROGNOSIS
Infiltrative margin of
tumor
Tumor progression
and enlargement
Clinical
manifestations:
Malignant
Enlargement of entire Phyllodes Breast
breast with distorted Tumor
shape
Tumor becomes Affects the other
invasive/ Malignant breast
Neoplasm
IF TREATED IF UNTREATED
Surgical Management:
Excision Biopsy
Mastectomy
Enter the blood stream
and metastasize to other
sites of the body/
Systemic metastases
GOOD
PROGNOSIS
Spreads to major
organs
Compromise functions
of major organs
DEATH