Volume 325, Issue 5813, ei COVER DEPARTMENTS Asolrfarm coletsa tiny faction 731 Science Onine af the 174,000 teraatsf enerey 733. This Wek inscence Stking Eat in the frm of sunlight 732 Editors Choice 12005, the at of gol energy 742 ConeetSderce consumption was about 16.3 terawatts. 743 Randoms Samples ‘See the special section on sustainability 745 Newsmakers aad energy begining on page 781 867 New Products Photo ilustvaton: Kelly Krause’Scence B71 Science Careers Omages: Getty Digital Vision) EDITORIAL sp. 737: Sclence Carers sctin p.68 737 Eneigy and Sustainability ne motel and Podcest ee. 7 bylonn # Holdren PECIAL SECTIOI Sustainability and Energy INTRODUCTION ney forthe Long Haul re NEWS AStstinbl Ft, We Pay Up Fert 182 Steringa National Lab to the ight 724 Eurela emer Pus Sled Sb els on Yak 785 Von Nke Bruel ly Pepa 786 SrallTinking eid Feth ond the Beauty Fine ess 787 Fu fo Smal Farms 708 Wr Up Eurep's ost 703 Hydrogen Economy? Let Sunlight Do the Work 78? NEWS OF THE WEEK Ghidng on Ol Tanker ne Renensble ters 790 Inrationa Team Releases Design, ot fr Treading he Mur Fel ye Minefield ma ot es atilesmoshe NoroyAttucer Demonstration Proje? 2 6 BlsBg on UC evo for Noe Blue Cente 747 Rethinking other tre’ Chics 193 FacsmAlegatons Tat Chee fot ikect 748 Former Having Sekse Medel CHPRESS 798 Catalyzing the Emergence of a Practical Biorefinery 795, om Reversed in Mice 749 PERSPECTIVES 'SCIENCESCOPE 749 Doni Forget Lengerm Fndanertl Reseach in Enetgy 798 Reseach Res—andals—inthePeien’s 750 Ga Wnstoutsond GW Crate Spending Pan Towa Cote Slr Ener se 798 MSs wc Sere Challenges in Engineering Microbes for Biofuels Production 801 NSF Eduction Program Rebowne Biomas Reelivarce: Engineering PantsardEamestor 608 NEWSIROCUS! Blots Preducton ss Spat Pent sss Pome ee Maing 4 hl Saleem ato 08 Fee ccomenasoaaer Reena Energy Sources andthe Rais of setting an 810 Stik ot ai ec MS a Ener Aaena Contoenal aon Ces Coming tothe Ome 760 rep apn 12 ali wauscioncemag.org SCIENCE VOL315 9 FEBRUARY 2007 728Science SCIENCE EXPRESS wunusciencexpress org MEDICINE Reversal of Neurological Detects in a Mouse Alodel of Ret Syndrome 1. Gay, J Gan. Selfidg, 5. Cobb, A. Bird ‘na mouse rpica of an auts-ite genetic cer, exctnation df he étectne gene ater somos appr ameliorates the ds, suggesting atherpeutcoppcoeh Ss neurstiyp 749 OA 126iscience 1136389 ‘STRUCTURAL BIOLOGY Crystal Structures ofthe Adenylate Sensor from Fission Yeast AMP-ActWvated Protea Kinase 2, Townley end. Shapiro Thecystal srucurect a key metabolic relator reas how it senses the aio fATP to AMT, jnitting ledack processes c optimize ATPLevesin the ce IOLI28cienee, 1137503 CONTENTS i ATMOSPHERIC SCIENCE Rapid Changes in ce Discharge from Greenland Outlet Glaciers LM. Honat, | R.Joughin, A Scambos Satelite measureents show tht the echarge fom two major outlet elacrsof the Greenland ce Shee coud in 2004 but then dexreased arty n 2008, OL 126icience.1138478 Paysics ‘An Intrinsic Bond- Centered Electronic Glas with Unidirectional Domains in Underdaped Cuprates Y.Kohsoka etal. “wo families of cpratesupeconducorsare shown e share aconrnen electronic supersucute at ay be the precusr phase tothe onset superonductviy OL126science 1138584 LETTERS Limits to the Human Cancer Genome Project? 762 W.l. Chng: L.A, Loeb and. H, Biel: B.S. Srouss Response £ Sjobiom eta Gene Expression and Ethnic Differences M.S. Biinger CORRECTIONS AND CLARIFICATIONS 766 BOOKS &7 Al. Contemporary Poetry and ContemporaryScience 747 2. Crawford, Ed, reviewed by 0. Ackerman The First Scientific American Benjamin Franklin and 768 the Pursuit of Genius J. Chopin, reviewed by HF. Oyllo POLICY FORUM Time fora New Era of Science Diplomacy 769 1M. Lord and V.C. Turekian PERSPECTIVES Antennae as Gyroscopes ™m RM, Alexander >> Fepat 853 Pumping Up Surace Air m7, Le Joeglé >> Research Aritep 316 jt Insight into Bacterial Gliding m3 DB. Kearns >> perp. £53 Can Droplets and Buibles Think? 78 LR Epstein => Reprtspp. 828 end 932 Cellular Demolition and the Rules of Engagement 776 Rk. Youle >> Report 56 Picaplankton Do Some Heavy lilting m RT Borber »>Repoitp 838 773 & 853 ‘ynwscioncemag.org SCIENCE VOL315 9 FEBRUARY 2007 TECHNICAL COMMENT ABSTRACTS MEDICINE Comment on “Obestatn,« Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin’ Effects on Food Intake” 1M. Chartel et al hl cata amascieneres.o1egltomtenthil315/58137 6c 766 Response to Comment on “Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghreln’s Effects on Food Intake” JV. hang etal il tet ot wscencemeg ang egomtanu 31881317660 BREVIA PLANETARY SCIENCE Enceladus: Cosmic Graffiti Ast Caught in the Act 815 A Verbiscer, French, M. Showalter, P Helferstin ue space ieascope servations inlato at patios emitted {cam Saturn's noon Enceladus cole with other stlites inthe ‘ame ing, creasing te ales, RESEARCH ARTICLES [ATMOSPHERIC SCIENCE Direct Measurements of the Convective Recy 816 of the Upper Iroposphere TH. Berton etal Diet measurerets imply tat therate of deep convecion inthe toosphere may be faster than prec, atlecing our understanding of chemiareacton ina ceLLeIcLoGy Adembrane Receptor for Retinol Binding Protein 820 Imadiates Celular Uptake of Vitamin A Kawaguchi etal. ‘A membrane petein wth 2 previously unre futon binds the caer roten fr warn A, causes release ofthe vitamin, an anspor it ica calic CONTENTS continued >> 727