Patophysiology

Risk Factor

Luminal
Obstruction

Increase Mucosal
Secretion

Increase intraluminal
pressure

Exceeds capillary perfusion Epithelial mucosal

pressure secretions accumulate

Venous and Arterial stasis and

lymphatic drainage tissue infarction
are obstructed

Intraluminal Appendical
STAGNATION exceeding the hypertension distention
appendix capacity of 0.1-0.3
ml
Venous out Visceral afferent fibers are
Loss of epithelial flow stimulated enters the 10th
integrity obstruction thoracic vertebral level

Ischemia Referred Epigastric Periumbilical

pain pain

Vascular constriction and

susceptibility to bowel flora Inflamation of
invasion serosa & adjacent
structure
Thrombosis of
appendicular artery and Triggers somatic pain fibers
vein innervating PERITONEA
structures
Luminal bacteria
multiply Radiating pain in the
periumbilical area to the RLQ
Perforation and spillage of
infected appendical contents in
PERITONEUM

APPENDICITIS
Gangrene occur