Anacardic Acid Size

Cat. No. 172050 10 mg

Synonyms: AA; 2-Hydroxy-6-pentadecylbenzoic acid; 6-Pentadecylsalicylic acid

Description: A cell-permeable salicylic acid analog that acts as a potent, non-

competitive inhibitor of p300 and PCAF (p300/CBP-associated factor)
histone acetyltransferase (HAT) activities (IC50 ~ 8.5 µM and ~ 5 µM,
respectively). Shown to affect HAT-dependent transcription from a
chromatin template and does not affect DNA transcription. Also reported
to display anti-microbial properties and to inhibit the activities of
prostaglandin synthase, tyrosinase, and lipoxygenase.

Form: Off-white solid. Packaged under inert gas.

Molecular Weight: 348.50

Molecular Formula: C22H36O3

Structure: OH O

OH

Purity: ≥95% by HPLC

Solubility: DMSO (10 mg/ml) or Ethanol (10 mg/ml)

Storage: Refrigerator (+4°C). Protect from light. Following reconstitution aliquot

and freeze (-20°C). This product is stable for 3 years as supplied. Stock
solutions are stable for up to 3 months at -20°C.

References Balasubramanyam, K., et al. 2003. J. Biol. Chem. 278, 19134.

Paramashivappa, R., et al. 2002. J. Agric. Food Chem. 50, 7709.

FOR RESEARCH USE ONLY. NOT FOR HUMAN OR DRUG USE.

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Revised: 17-October-03
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