umping to specific locations in the worksheet:

Press Ctrl+G, and write the destination cell's address. For example: A100 

Ctrl+End will jump to the last cell of your data in the worksheet (the most bottom-
right cell). It is relevant if you have already some data written in your worksheet,
otherwise in an empty worksheet it will jump to the really last cell in the worksheet.
Try it. 

Ctrl+Home should jump the active cell to cell A1

Instantly opening useful dialog boxes:

Ctrl+1 (Ctrl and the number one) will open the "Format Cells" dialog box (very
useful!) 

Alt+E and then S – will open the "Paste Special" dialog box. If you want to use
the "Values" option from this dialog box, then continue and press Alt+v, and finish
with Enter.

Editing text:

Press F2 in a cell that has text, and a text cursor will appear at the end of it,
enabling you to add more content or edit the existing text. (This comes instead of
double clicking with the mouse inside the text, or clicking in the formulas bar to
edit it). 

Press Alt+Enter when writing text in a cell, to add a line break inside the cell.

Miscellaneous

Freeze panes: 
Put the active cell in the desired location, and press Alt+w and then F. 
To remove the freeze panes, use the same shortcut. 

Instantly insert a sum function: 

 Position the active cell underneath a column of numbers, and press Alt+= (Alt key
together with the equal sign) 

Instantly insert dates: 

To insert today's date, press Ctrl+; (a semicolon). 
To have today's date change dynamically to reflect always the current date
(whenever the worksheet is opened), then write the function =today() 

An instant chart: 
Select your data (it should be organized neatly with rows and column headers),
and press the F11 key.

And of course: all the general MS Office Shortcuts

To open the "Find" dialog box: Ctrl+F 

To open the "Find and replace" dialog box: Ctrl+H 
Save file: Ctrl+S 
Open a file: Ctrl+O 
Add a new Excel file (a new workbook): Ctrl+N 
Open the "Print" dialog box: Ctrl+P 
Ctrl+C to Copy a selection, Ctrl+X to cut, Ctrl+V to Paste. 
Save as… : The F12 key. 
Applying the formatting of Bold, Italic and Underline, will be
accordingly: Ctrl+B, Ctrl+I and Ctrl+U

Applying the formatting of Bold,