Patofisiologi Infark Otak

Iskemia Kerusakan Gangguan Nekrosis

Ca Influk
Membran Sel Sel

Asam lemak bebas

CDP Cholin Asam arakhidonat

Prostaglandin
Thomboksan
lekotrin

Free radical

( Dikutip dari Hacke W. Hennerici M 1991 )

Aterosklerosis
Ischemic Stroke
Precipitating Factors:
Predisposing Factors:
-Hypertension
-Hyperlipidemia -Life style (sedentary)
VASOCONSTRICTION -Vices (Alcohol, smoke)
-Diabetes Mellitus
-Heart Diseases -Age
-Atherosclerosis Blockage of the blood vessel -Diet
-Arteriosclerosis -Sex
-Thrombosis -Heredity
Embolism -Self-medication
-Severe dehydration
Lack of oxygen & nutrients High blood pressure, smoking, heart diseases, diabetes,
supply Ischemic Stroke narrowing of arteries supplying the brain, high
cholesterol and an unhealthy lifestyle.
Cerebral Ischemia
Hypoxia
Subarachnoid High blood pressure, smoking, and a family history of
Hemorrhage burst aneurysms.
- Cell death Altered cerebral
Severe dehydration, severe infection in the sinuses of
metabolism the head and medical or genetic conditions that
- Decreased Venous Stroke
increase a person’s tendency to form blood clots.
Intracerebral
Oxygen level hemorrhage Decreased cerebral
perfusion
Large Artery Strokes Hypertension, diabetes, smoking and high cholesterol
levels.

P Local

Acidosis Transient Ischemic

A Attack Same with Ischemic stroke
Cytotoxic
R Edema
Small Artery Stroke Hypertension, diabetes and smoking.
A Aneurysm

L Rupture Irregular heart beat (atrial fibrillation), a heart attack

Embolic strokes (myocardial infarction), heart failure or a small hole in
the heart called a PFO (Patent Foramen Ovale).
Y
S Brain tissue Necrosis
I
S Severe Cases
DEATH