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    TDDS

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    krchaudhari
    Transdermal drug delivery systems can deliver drugs through the skin and into the bloodstream, avoiding first-pass metabolism in the liver. This research proposal aims to formulate and evaluate a controlled-release TDDS containing a model drug with low solubility, high permeability, and poor bioavailability due to first-pass effect. Various TDDS formulations with different ingredient concentrations will be prepared, optimized based on physicochemical properties and in vitro drug release, and evaluated through in vivo studies to derive plasma concentration profiles and calculate bioavailability compared to other formulations.

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    TDDS

    Uploaded by

    krchaudhari
    42 views1 page
    Transdermal drug delivery systems can deliver drugs through the skin and into the bloodstream, avoiding first-pass metabolism in the liver. This research proposal aims to formulate and evaluate a controlled-release TDDS containing a model drug with low solubility, high permeability, and poor bioavailability due to first-pass effect. Various TDDS formulations with different ingredient concentrations will be prepared, optimized based on physicochemical properties and in vitro drug release, and evaluated through in vivo studies to derive plasma concentration profiles and calculate bioavailability compared to other formulations.

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    Transdermal drug delivery systems can deliver drugs through the skin and into the bloodstream, avoiding first-pass metabolism in the liver. This research proposal aims to formulate and evaluate a controlled-release TDDS containing a model drug with low solubility, high permeability, and poor bioavailability due to first-pass effect. Various TDDS formulations with different ingredient concentrations will be prepared, optimized based on physicochemical properties and in vitro drug release, and evaluated through in vivo studies to derive plasma concentration profiles and calculate bioavailability compared to other formulations.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as doc, pdf, or txt
    42 views1 page

    TDDS

    Uploaded by

    krchaudhari
    Transdermal drug delivery systems can deliver drugs through the skin and into the bloodstream, avoiding first-pass metabolism in the liver. This research proposal aims to formulate and evaluate a controlled-release TDDS containing a model drug with low solubility, high permeability, and poor bioavailability due to first-pass effect. Various TDDS formulations with different ingredient concentrations will be prepared, optimized based on physicochemical properties and in vitro drug release, and evaluated through in vivo studies to derive plasma concentration profiles and calculate bioavailability compared to other formulations.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
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    Research Proposal:

    Formulation and in-vivo evaluation of Transdermal


    Drug Delivery System containing model drug

    Transdermal Drug Delivery System (TDDS) is used to administer the drug in


    blood circulation through skin to avoid first pas effect. This system may used for
    enhancement of bioavailability of BCS class-II drugs. The controlled release
    TDDS will formulation is designed using low dose drug to maintain steady state
    plasma level for 24 hrs or more. Drug having low solubility but good permeability
    and having poor bioavailability due to first pass effect will selected as it better
    suites to formulate TDDS. Various TDDS formulation containing different
    concentration of ingredients will prepared and optimized by evaluating for
    physicochemical properties and in vitro drug release profile. In-vivo study will be
    carried out to derive the drug plasma concentration profile after the TDDS has
    been applied on skin. From these the bioavailability after TDDS application will be
    calculated and compared with that of other formulations containing same drug.

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