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    Dna Gyrase Inhibitor

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    Julia Ishak
    Flouroquinolones like ciprofloxacin are synthetic analogs of nalidixic acid that act as inhibitors of bacterial DNA gyrase and topoisomerase IV. They block bacterial DNA synthesis and interfere with chromosome separation in daughter cells. Resistance can develop through mutations in DNA gyrase and topoisomerase IV or changes in permeability. Fluoroquinolones are generally well-absorbed, concentrated in tissues, and excreted renally or nonrenally depending on the specific drug. They are used to treat a variety of bacterial infections from UTIs to respiratory and intra-abdominal infections. While usually well-tolerated, adverse effects can include nausea, headaches, tendinitis,

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    Dna Gyrase Inhibitor

    Uploaded by

    Julia Ishak
    36 views2 pages
    Flouroquinolones like ciprofloxacin are synthetic analogs of nalidixic acid that act as inhibitors of bacterial DNA gyrase and topoisomerase IV. They block bacterial DNA synthesis and interfere with chromosome separation in daughter cells. Resistance can develop through mutations in DNA gyrase and topoisomerase IV or changes in permeability. Fluoroquinolones are generally well-absorbed, concentrated in tissues, and excreted renally or nonrenally depending on the specific drug. They are used to treat a variety of bacterial infections from UTIs to respiratory and intra-abdominal infections. While usually well-tolerated, adverse effects can include nausea, headaches, tendinitis,

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    Flouroquinolones like ciprofloxacin are synthetic analogs of nalidixic acid that act as inhibitors of bacterial DNA gyrase and topoisomerase IV. They block bacterial DNA synthesis and interfere with chromosome separation in daughter cells. Resistance can develop through mutations in DNA gyrase and topoisomerase IV or changes in permeability. Fluoroquinolones are generally well-absorbed, concentrated in tissues, and excreted renally or nonrenally depending on the specific drug. They are used to treat a variety of bacterial infections from UTIs to respiratory and intra-abdominal infections. While usually well-tolerated, adverse effects can include nausea, headaches, tendinitis,

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as docx, pdf, or txt
    36 views2 pages

    Dna Gyrase Inhibitor

    Uploaded by

    Julia Ishak
    Flouroquinolones like ciprofloxacin are synthetic analogs of nalidixic acid that act as inhibitors of bacterial DNA gyrase and topoisomerase IV. They block bacterial DNA synthesis and interfere with chromosome separation in daughter cells. Resistance can develop through mutations in DNA gyrase and topoisomerase IV or changes in permeability. Fluoroquinolones are generally well-absorbed, concentrated in tissues, and excreted renally or nonrenally depending on the specific drug. They are used to treat a variety of bacterial infections from UTIs to respiratory and intra-abdominal infections. While usually well-tolerated, adverse effects can include nausea, headaches, tendinitis,

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    DNA GYRASE FLOUROQUINOLONES NALIDIXIC ACID CINOXACIN

    INHIBITOR
    OVERVIEW - synthetic florinated analogs -1st antibacterial quinolones -1st antibacterial quinolones
    of nalidixic acid - not flourinated - not flourinated
    - excreted too fast - excreted too fast
    RESISTANCE - Enzyme mutation-
    DNA gyrase,
    topoisomerase IV
    - Permeability change
    - Cross resistance
    occurs
    MECH. OF ACTION -Block bacterial DNA synthesis
    -It bacterial topoisomerase II
    (DNA gyrase)→ prevent
    relaxation of positively
    supercoiled DNA
    -topoisomerase IV : intefere
    chromosome separation to
    daughter cells
    ACT ON - Gram + ve bac
    - Gram –ve bac

    PHARMACOKINETICS Excretion:
    Renal
    -ciprofloxacin
    -clinafloxacin
    -enoxacin
    -norfloxacin
    -ofloxacin

    Nonrenal:
    -moxifloxacin

    Oral: well-absorbed
    Elimination: kidney
    Concentration: prostate,
    kidney, neutrophils, m0

    CLINICAL USES  UTI


     Bacterial dirrhea
     Soft tissue infctn
     Bones n joint infctn
     Intraabdominal infctn
     Respiratory tract infctn
     Ciprofloxacin- gonococcal,
    chlamydial urethritis,
    legionellosis (2nd line),
    TB, atypical mycobacteria
    ADVERSE EFFECTS  Extremely well tollerated
     Nausea, vomiting, dirrhea
     Headache, dizziness,
    insomnia, skin rash
     Contraindicated in
    pregnant mother

    Others:
     Arthropathy
     Tendiritis
     Hepatitis
     Hepatic failure
     Photosensitivity
     Cardiac arrythmia

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