Professional Documents
Culture Documents
Biosensors: Christopher Byrd
Biosensors: Christopher Byrd
Christopher Byrd
ENPM808B
University of Maryland, College Park
December 4, 2007
Outline
Introduction
4 Specific Types of Biosensors
Electrochemical (DNA)
Carbon nanotube
BioFET
Whole Cell
Basic functionality
Benefits/Challenges
Summary
References
Introduction
Biosensor:
Biosensors ~ $3B
90% → Glucose testing
8% - 10% increase in industry per year
(Target Sequence)
(Hybridization)
“Stem-loop”
Gold electrode
“Stem-loop”
Gold electrode
(Open, extended)
(Stem-loop)
Image: www.cnano-rhone-alpes.org
Succinimidyl ester
Glucose
O2
Gluconic Acid
H2O2
e-
e- e- e-
e-
160 mM
60 mM
20 mM
0 mM
Drain Gate
Insulator
Source
+ + + +
(Not conductive enough)
(Electron Channel)
- - -
- -
-
Threshold Voltage
Drain Gate
Insulator
Source
+ + + +
Drain Gate
Insulator
Source
++ +++ + ++
- - - - - -
- -
- - -
- -
Source: http://www.whatsnextnetwork.com/technology/media/cell_adhesion.jpg
Temperature/pH sensitive
Short shelf-life
(Side view)
Suction
Suction
Regardless of challenges:
Biosensors will permeate future society