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  • RX25 Lipidmet

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    Illa Adeng
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    The document discusses lipid metabolism and energy production from fatty acid oxidation. It notes that the initial step of fatty acid oxidation requires ATP to synthesize acetyl CoA. It then examines the breakdown of palmitic acid (C16), finding that each turn of the fatty acid beta-oxidation spiral produces 5 ATP, with palmitic acid producing 34 ATP net. It further discusses that each turn of the citric acid cycle from the acetyl CoA products generates 12 ATP, resulting in a total of 130 ATP from full oxidation of palmitic acid.

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    RX25lipidmet

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    The document discusses lipid metabolism and energy production from fatty acid oxidation. It notes that the initial step of fatty acid oxidation requires ATP to synthesize acetyl CoA. It then examines the breakdown of palmitic acid (C16), finding that each turn of the fatty acid beta-oxidation spiral produces 5 ATP, with palmitic acid producing 34 ATP net. It further discusses that each turn of the citric acid cycle from the acetyl CoA products generates 12 ATP, resulting in a total of 130 ATP from full oxidation of palmitic acid.

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    14 views23 pages

    RX25 Lipidmet

    Uploaded by

    Illa Adeng
    The document discusses lipid metabolism and energy production from fatty acid oxidation. It notes that the initial step of fatty acid oxidation requires ATP to synthesize acetyl CoA. It then examines the breakdown of palmitic acid (C16), finding that each turn of the fatty acid beta-oxidation spiral produces 5 ATP, with palmitic acid producing 34 ATP net. It further discusses that each turn of the citric acid cycle from the acetyl CoA products generates 12 ATP, resulting in a total of 130 ATP from full oxidation of palmitic acid.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as ppt, pdf, or txt
    of 23

    Lipid Metabolism

    Lipid Metabolism
    Lipid Metabolism
    Lipid Metabolism
    • Digestion - Hydrolysis Reaction
    Lipid Metabolism
    Lipid Metabolism
    Fatty Acid Oxidation
    • Initial Step: Requires an ATP to synthesize acetyl CoA with the fatty acid.
    Beta Oxidation
    Beta Oxidation
    Beta Oxidation
    Beta Oxidation
    Beta Oxidation
    Beta Oxidation
    Beta Oxidation
    Palmitic Acid Review
    Palmitic Acid -ATP Synthesis
    • Palmitic Acid is C-16
    • Initiating Step - requires 1 ATP (text says 2)
    • Step 1 - FAD into e.t.c. = 2 ATP
    • Step 3 - NAD+ into e.t.c. = 3 ATP
    • Total ATP per turn of spiral = 5 ATP
    • Example with Palmitic Acid = 16 carbons = 8
    acetyl groups
    • Number of turns of fatty acid spiral = 8-1 = 7 turns
    • ATP from fatty acid spiral = 7 turns and 5 per turn
    = 35 ATP.
    • NET ATP from Fatty Acid Spiral = 35 - 1 = 34
    ATP
    Palmitic Acid (C-16) -ATP Synthesis
    • NET ATP - Fatty Acid Spiral = 35 - 1 = 34 ATP
    • Review ATP - Citric Acid Cycle start with Acetyl CoA
    • Step ATP produced
    • 7 visible ATP 1
    • Step 4 (NAD+ to E.T.C.) 3
    • Step 6 (NAD+ to E.T.C.)   3
    • Step10 (NAD+ to E.T.C.)  3
    • Step 8 (FAD to E.T.C.) 2
    •  NET 12 ATP per turn C.A.C.
    • 8 Acetyl CoA = 8 turns C.A.C.
    • 8 turns x 12 ATP/C.A.C. = 96 ATP
    • GRAND TOTAL 130 ATP
    Acetyl CoA
    Ketone Bodies
    Ketone Bodies
    Blood Glucose and Glucosuria
    Ketone Bodies
    Lipogenesis

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