17-Ketosteroid

A 17-ketosteroid is a steroid that has a ketone (C=O) functional group at the 17

position.

Examples of 17-ketosteroids include:

 Androstenedione
 Androsterone
 Estrone
 Dehydroepiandrosterone.

Androstenedione (also known as 4-androstenedione) is a 19-carbon steroid hormone

produced in the adrenal glands and the gonads as an intermediate step in the
biochemical pathway that produces the androgen testosterone and the estrogens
estrone and estradiol

Androsterone (ADT) is a steroid hormone with weak androgenic activity. It is made in

the liver from the metabolism of testosterone

Estrone (also oestrone) is an estrogenic hormone secreted by the ovary as well as

adipose tissue.

Estrone is one of the three estrogens, which also include estriol and estradiol.
Estrone is the least abundant of the three hormones, estradiol is present almost
always in the reproductive female body, and estriol is abundant primarily during
pregnancy.

Estrone is relevant to health and disease states because of its conversion to estrone
sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be
converted as needed to the more active estradiol.

5-Dehydroepiandrosterone (5-DHEA) is an endogenous steroid that has been

implicated in a broad range of biological effects in humans and other mammals.
Together with its sulfate ester (DHEA-S), it is the most abundant steroid in humans.
DHEA is produced by adrenal glands, but also synthesized de novo in the brain. It acts on
the androgen receptor both directly and through its metabolites, which include
androstenediol and androstenedione, which can undergo further conversion to produce
the androgen testosterone and the estrogens estrone and estradiol.[2] DHEA is also a
potent sigma-1 agonist.[3] It is considered a neurosteroid.