Pa Tho Physiology of Cervical Cancer

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PATHOPHYSIOLOGY

OF CERVICAL CANCER
Risk Factors
HPV infection of the external genitalia and
anus (most common)

Early intercourse (before 16 y/0)

Multiple sex partners

History of STIs

Infection with HIV


Other Risk Factors
Smoking

Poor nutritional status

History of cervical cancer

Untreated chronic cervicitis


Pre-Invasive Stage

Cervical Dysplasia in cervical


epithelium

Mild Moderate Severe Carcinoma


(CIN 1) (CIN 2) (CIN3) in situ
Invasive Stage
Begins at the squamocolumnar
junction, near the external end of
the cervix

Direct invasion of accessory structures

Vaginal Lower
Pelvic
uterine Bladder Bowel
wall segment wall
Signs and Symptoms according to areas affected
Bleeding after
intercourse
Vaginal Wall
Dark, foul
smelling
discharges

Heavy, aching,
Pelvic Wall
abdominal pain
Metrorrhagia

Post-menstrual
bleeding
Lower Uterine Segment
Polymenorrhea

Uteral obstruction
Bladder irritation

Bladder Pressure on bladder

Hematuria

Rectal discharge

Bowel Pressure on bowel

Bloody stools
Metastasis
•Metastasis occurs mainly through
lymphatic spread with some spread
occurring through the circulatory system
to the:
LIVER
LUNGS
BONES

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