www.sciencemag.org/cgi/content/full/science.

1207018/DC1

Supporting Online Material for

Widespread RNA and DNA Sequence Differences in the Human
Transcriptome
Mingyao Li, Isabel X. Wang, Yun Li, Alan Bruzel, Allison L. Richards, Jonathan M.
Toung, Vivian G. Cheung*

*To whom correspondence should be addressed. E-mail: vcheung@mail.med.upenn.edu

Published 19 May 2011 on Science Express
DOI: 10.1126/science.1207018

This PDF file includes:

Materials and Methods
Figs. S1 to S5
Tables S1 to S10
References

SUPPLEMENTAL ONLINE MATERIAL

Widespread RNA and DNA Sequence Differences in the Human Transcriptome
Mingyao Li, Isabel X. Wang, Yun Li, Alan Bruzel, Allison L. Richards, Jonathan M. Toung, Vivian G.
Cheung
Table of content
1.

Figure 1. Flowchart of analysis

2.

Figure 2. Comparison of editing levels for A-to-G sites in our and Church studies

p. 2-3

p. 4
3.

Figure 3. Examples of RDD sites by Sanger Sequencing

p. 5

4.

Figure 4. Comparison of the number of events per individual by SNPs and by monomorphic sites
p. 6

5.

Figure 5. Editing/ RDD levels by frequency

6.

Results from comparison of RDD sites obtained from our RNA-Seq reads and those from Dermitzakiss
and colleagues.
p. 8

7.

Sequencing errors and coverage do not contribute to individual differences in number of RNA editing/
RDD events
p. 9

8.

Material and Methods

p. 10-13

9.

Table 1. Information on the 27 subjects in our study

p. 14

p. 7

10. Table 2. Sequences corresponding to RDD sites translated to peptides

p. 15
11. Table 3. EST clones that contain RDD alleles

p.16-18

12. Table 4. DNA and RNA-forms of peptides at RDD sites (cancer cells)

p. 19

13. Table 5. DNA and RNA forms of peptides at RDD sites (B-cells)

p. 20-26

14. Table 6. Gene Ontology Analysis of RDD containing genes

p. 27

15. Table 7. Distribution of RDD sites across different genic regions

p. 28

16. Table 8. Primers used in Sanger sequencing

p. 29-30

17. Table 9. Detailed information on peptides from mass spec

p. 31-40

18. Table 10. Description of the 10,210 RDD sites

p. 41-147

19. References

p. 148

Supplementary Figure 1A.

Flowchart of analysis

50bp sequencing reads (n = 27)

~41 million reads per individual

Map reads to Gencode hg18 mRNA

sequences with Bowtie v0.12.7
using default options

Extract uniquely mapped reads

~28.3 million reads per individual

Compile a SNP list based on 1000 Genomes,

HapMap, and dbSNP 130 data

Pileup uniquely mapped reads

using SAMTOOLS

Compile a list of monomorphic sites that are

not present in the above SNP list

For each site, filter out read bases with

base quality < 25 and recalculate coverage
Recalculate read coverage

For each individual, extract homozygous

genotypes from 1000 Genomes and HapMap

Extract sites with read coverage 10

~9.8 million sites per individual

Remove discordant genotypes for overlapping

SNPs between 1000 Genomes and HapMap

Declare an A-to-B RNA editing/ RDD event at a site for an individual if

1) DNA genotype = A/A and coverage 4 in 1000 Genomes
2) (#A + #B)/total reads 0.9 in RNA-Seq
3) #B/(#A + #B) 0.1 in RNA-Seq
4)

Compile a list of RNA editing/ RDD events across 27 individuals and

remove singleton events

Figure 1B.

Different data generated and analyses conducted in this study.

Fig. S2.ComparisonofAtoGlevelsinBCells(thisstudy)andthoseinothercelltypescollectedbyG.Church'sgroup
1
0.9
B cell
Cerebellum (Church)

0.8

Frontal Lobe (Church)

Corpus Callosum (Church)

0.7

Diencephalon (Church)

Lev
Level

0.6

Small Intestine (Church)

Kidney (Church)

0.5

Adrenal (Church)

04
0.4
0.3
0.2
0.1
0

Figure S3. Examples of RDD sites by Sanger sequencing. Sequences of matched DNA and RNA sequences from
cultured B-cells for four genes are shown. Each matched pair of DNA and RNA sequences was from the same individual.
The reverse strand of EIF2AK2, AZIN1 and BLCAP was sequenced. Locations of the sites are based on hg18 build of the
human genome.

Fig. S4. Comparison of the number of RDD events

per individual by SNPs and monomorphic sites.

Fig.S5. Editing and RDD levels by frequency.

Comparison of our analysis using our RNA-Seq data and those previously generated (25):
Instead of aligning our sequence reads to Gencode regions of the reference human genome. We
aligned the sequences to the entire reference genome. For that analysis, we required each site to
be covered by 20 or more reads and a RDD site is called only if 20% or more of the reads cover a
site that differs from the DNA sequence. With these criteria, among the 27 subjects, we
identified 101,574 events where the RNA sequences do not match those of the corresponding
DNA sequences in our 27 subjects. These events are found in 20,753 sites in the human genome
and reside in 4,507 known genes.
Independently, Dermitzakis and colleagues have performed RNA-sequencing on the same set of
CEPH individuals(25). This provides an opportunity to validate our findings on a genome scale.
We took their RNA-Seq data and used the same analysis pipeline to identify RDD sites. They
did not sequence the samples as deeply as we did (0.7 Gb vs 2 Gb per sample) so we could not
compare all the sites. However, we were able to compare a large number of sites; among the
101,574 events identified in our data, 19,243 events have coverage 20 in the Dermitzakiss
dataset. Among these events, 17,100 (89%) showed identical RNA-DNA differences as in our
dataset. Because we applied a stringent requirement that 20% or more of the RNA-Sequencing
reads has to differ from the DNA to call a site, the 89% concordance with Dermitzakiss data is
likely an underestimate. The results are encouraging since the RNA-Seq data were generated by
two labs independently, yet the findings are highly concordant.

Sequence errors or coverage do not contribute to individual differences in number of RDD

events:
One concern with these individual differences is sequencing errors particularly for those
monomorphic sites since subjects in the 1000 Genomes Project were sequenced at low depth. To
eliminate such a possibility, we compared the number of events between SNPs and
monomorphic sites found in each individual and observed similar patterns (Spearman correlation
= 0.74, P < 10-7; Fig. S4). We have confidence in the SNP genotypes because the genotypes
from the 1000 Genomes Project were based on consensus calls using three different genotype
calling algorithms19 and for SNPs that were found in the 1000 Genomes and the HapMap
Projects, we considered only those with concordant genotypes. The similar patterns between
SNPs and monomorphic sites provide reassuring evidence that genotyping errors are unlikely to
explain the variability among individuals. Another concern with the individual variation in the
number of events is that the RNAs of different individuals were sequenced at different depths.
To evaluate the potential impact of sequencing depth, we fitted a linear model with the number
of events as the outcome variable and the number of bases covered by 10 or more reads as
independent variable and found that the number of events and sequencing depth are not
dependent (P = 0.51), suggesting that the variability is not due to variation in coverage.
Similarly, the depth of DNA sequences from 1000 Genomes cannot explain the individual
differences in the number of RDD events (P = 0.12). These analyses suggest that the individual
variation in the number of editing and RDD events has a biological basis.

MATERIALS AND METHODS

MATERIALS AND METHODS
Study samples
We used data generated by sequencing RNA from 27 cultured B-cell lines obtained from
Coriell (Camden, NJ, USA). These cell lines were derived from individuals of European descent
from the Utah pedigrees of the CEPH collection which have been extensively genotyped or
sequenced by the International HapMap and the 1000 Genomes Projects. All individuals are
unrelated. The list of individuals is shown in Table S1. The B-cells were grown to a density of 5
x 105 cells/mL in RPMI 1640 supplemented with 15% fetal bovine serum, 100 units/mL
penicillin and 100 g/mL streptomycin, and 2 mmol/L L-glutamine.
Foreskin tissues were collected from circumcisions of 10 healthy and unrelated 3-day old
newborns (anonymous donors at the Hospital of the University of Pennsylvania). Primary
fibroblasts were isolated from these foreskin tissues. Briefly, the tissues were sectioned and the
epidermis was removed. The remaining dermis was incubated in 1 ml of 3 mg/ml collagenase
(Roche, Indianapolis, IN, USA) in HBSS buffer with calcium and magnesium (Mediatech,
Manassas, VA, USA) at 37C for 30 minutes. 1 ml of 0.5% Trypsin/EDTA (Invitrogen,
Carlsbad, CA, USA) was then added and the tissue was incubated at 37C for 10 minutes. After
inactivating trypsin by adding 1 ml MEM medium (Invitrogen) with 10% fetal bovine serum
(Hyclone, Logan, UT, USA), undigested tissue pieces were removed and fibroblasts were
collected from suspension by centrifugation. Passage-1 fibroblasts were subsequently cultured at
37C in 5% CO2 in MEM medium supplemented with 10% fetal bovine serum, 2 mMmol/LLglutamine, 100 U/mL penicillin and 100 g/ml streptomycin, and were passaged every 3 days.
Human brain tissues were obtained from National Disease Research Interchange. Tissues
from cerebral cortex were collected during routine autopsy of cardiac-death donors within 7~12
post-mortem hours. Samples were snap-frozen and kept at -80C until DNA/RNA extraction. All
10 subjects were Caucasians with age of 43~79 years, including both males and females.
Library preparation for Illumina sequencing and sequence alignment
RNA-Seq was performed as recommended by the manufacturer (Illumina, Hayward, CA,
USA). Briefly, cells were harvested 24 hours after addition of fresh medium and total RNA was
extracted using the RNeasy Mini kit with DNase treatment (Qiagen, Valencia, CA, USA). PolyA
mRNA was isolated and fragmented. First strand cDNA was prepared using random hexamers.
Following second strand cDNA synthesis, end repair, addition of a single A base, adaptor
ligation, agarose gel isolation of ~200 bp cDNA and PCR amplification of the ~200 bp cDNA,
the samples were sequenced using the Illumina 1G Genome Analyzer to a coverage of
approximately 41 million 50-bp reads per sample. High quality reads were mapped to the
Gencode mRNA sequences (build hg18) using program Bowtie (40) (v0.12.7). We used the
default settings of Bowtie (allowing up to two mismatches) and then extracted uniquely mapped
reads from the obtained SAM file.
Identification of RNA editing and RDD events
We required the RNA editing or RDD site to be homozygous in the genomic DNA. Such
a site can be either a SNP with homozygous genotype or a monomorphic site (i.e, a site not in
dbSNP, and not among SNPs identified by the HapMap and the 1000 Genomes Projects). If it is
a SNP, we obtained the corresponding SNP genotypes from the HapMap and the 1000 Genomes
Projects. For overlapping SNPs between these two projects, we required the genotypes to be

10

concordant. If it is a monomorphic site, we assumed all individuals are homozygous for the
reference allele in the reference genome. We detected RNA editing or RDD events by comparing
genotypes derived from DNA-Seq with those from RNA-Seq on the same individual.
For each individual, an event is declared at a site if 1) the number of uniquely mapped
reads in RNA-Seq is 10 and the per-base sequence quality score for each of the covered base is
25, 2) the number of uniquely mapped reads in DNA-Seq is 4 in the1000 Genomes Project, 3)
the individual's genotype at the site is homozygous, and 4) 10% of the mapped reads in RNASeq show an allele that differs from the individual's (DNA-level) genotype. We removed all sites
that overlap with segmental duplications (defined by
http://humanparalogy.gs.washington.edu/build36/build36.htm) and repetitive sequences (defined
by RepeatMasker).
EST search
We analyzed those RDD sites where the DNA sequences are monomorphic (not known
as SNPs in dbSNP, HapMap or 1000 Genome projects). For each site, we used BLAST to search
for sequences corresponding to the RNA-allele and 25 nucleotides up and downstream of that
site in human dbEST. An EST is found to contain the RDD allele if its sequence is identical to
the RNA-form of the RDD site and there is no more than 1 mismatch (except for known SNPs)
to the 51-nucleotide query sequence. The EST must also map to the gene where the RDD was
called (the mapping is mostly according to Unigene).
Validation with Sanger sequencing
To validate whether the sites we identified show RNA and DNA differences and to
confirm the RNA editing/ RDD level, we carried out Sanger sequencing. Genomic DNA and
total RNA were extracted using the Qiagen AllPrep DNA/RNA kit (with DNase treatment for
total RNA) from B-cells and foreskin fibroblast. DNA and RNA from human brain tissues were
extracted using Gentra Puregene Tissue Kit and RNeasy Lipid Tissue Mini kit (Qiagen),
respectively. RNA was converted to single stranded cDNA using TaqMan reverse transcription
reagents with oligo d(T) priming (Applied Biosystems, Foster City, CA, USA). PCR products
(see Supplementary Table 8 for primer sequences) encompassing putative RNA editing sites
were generated from the cDNA and sequenced using BigDye Terminator Cycle Sequencing on a
3730 DNA Analyzer (Applied Biosystems). RNA editing/ RDD sites were validated by visual
inspection of sequencing traces independently by at least two individuals.
Mass spectrometry
Protein Database with RDD sites: We made a protein database using Gencode mRNA
sequences. For genes that display non-synonymous RDDs, protein forms predicted from both
DNA sequences and RNA sequences were included. This database consists of 17,726 protein
entries, among which 2,057 proteins contain RDD sites. This allows us to search for spectra of
peptides encoded by the DNA and RNA forms of mRNAs simultaneously. Mass spectrometry
data were searched against this database using a locally installed version of Mascot search engine
(41) (Matrix Science, Boston, MA, USA). In order to evaluate the certainty of search result and
false discovery rate, we included a decoy database search. The decoy database contains the
reversed amino acid sequences of each protein contained in the original database, thus no true
matches should be expected (43). Each dataset was searched against both the original and the

11

decoy databases, using the same parameters. The false discovery rate (FDR) was determined
using the number of the matches from the original database (TP) and those from decoy database
(FDR=FP/(TP+FP)).
Ovarian cancer and leukemic cells: First we mined public databases for large-scale mass
spectrometry data on human cells. We found two comprehensive datasets on proteomic profiling
of ovarian cancer cells (29) and leukemic cells, K562
(https://proteomecommons.org/dataset.jsp?i=76466). The data were downloaded from Proteome
commons database. The downloaded m/z XML files were converted to Mascot compatible
format using ReAdW (42). We used the following search parameters of Mascot: for the ovarian
cancer cells, we used the same parameters as the original study(29): Parent ion mass of 4 Da,
fragment mass error of 0.4 Da, complete carbaminomethyl modification of cystein, and allow
one trypsin miscleavage; for the leukemic cells: parent ion mass of 0.3 Da, fragment mass error
of 0.5 Da, complete carbaminomethyl modification of cystein and variable N-terminal
acetylation and methionine oxidation, allowing up to one trypsin miscleavage (same as B-cells,
see below). False discovery rate is <1% (determined by Mascot decoy database search).
B-cells:Cultured B-cells from 15 CEPH indivduals were cultured as described above for
GEL/LC-MS/MS. Equal number of cells from each individual were pooled and lysed in 20 mM
Tris HCl pH 8, 137 mM NaCl, 10% glycerol, 1% Nonidet P-40 (NP-40) and 2 mM EDTA. 60
g of total protein was pre-fractionated and digested as described by Beer and colleagues (44).
Specifically, the sample of 60 g of total protein was loaded onto a 12% NuPAGE Bis-Tris gel
and was run until the dye reached 2 cm from the bottom of the loading well. The gel was stained
with Coomassie R250 and destained using methanol and water. The entire lane of protein was
sliced into 27 1-mm slices using a razor array. Gel slices were destained in 200 l of 200 mM
ammonium bicarbonate and 50% acetonitrile for 30 minutes with shaking at 37C and then dried
in a Speedvac. This was followed by incubation in 100 l of 20 mM TCEP in 25 mM
ammonium bicarbonate (pH 8.0) for 15 minutes at 37C. The supernatant was discarded and 100
l of 40 mM iodoacetamide in 25 mM ammonium bicarbonate (pH 8.0) was added and incubated
for 30 minutes at 37C. The supernatant was again discarded and the gel slices were washed
twice with 200 l of 25 mM ammonium bicarbonate in H2O and once with 25 mM ammonium
bicarbonate in 50% acetonitrile. The gel slices were dried and then rehydrated with 20l of 0.02
g/l modified Trypsin (Promega, Madison, WI, USA) in 40 mM ammonium bicarbonate
overnight with shaking at 37C. The supernatant was then transferred to a clean tube and the gel
slices were incubated in 20 l of 40 mM ammonium bicarbonate for 30 min at 37C. The
supernatants were combined and 4 l of acetic acid was added. Extracted tryptic peptides were
injected onto a nanocapillary reverse-phase column (75 m column terminating in a nanospray
15 m tip) directly coupled to a LTQ-Orbitrap mass spectrometer (Thermo Scientific, Pittsburgh,
PA, USA). The MS/MS data was acquired using a top six method. Each fraction of tryptic
peptides was injected and analyzed in triplicates to increase the depth of protein detection. The
raw spectra files were converted to Mascot compatible format using BioWorks v 3.3.1 (Thermo
Scientific, Waltham, MA, USA). We used the same protein database as in the cancer cell
analysis described above. The following Mascot search parameters were applied: parent ion
mass of 0.3 Da, fragment mass error of 0.5 Da, complete carbaminomethyl modification of
cystein and variable N-terminal acetylation and methionine oxidation, allowing up to one trypsin

12

miscleavage. False discovery rate is <1% (determined by Mascot decoy database search); see
Table S9 for details on search results.
At FDR <1%, 38,572 unique peptides (from 3,217 proteins) were detected. Among
them, 11,496 peptides are from the 659 proteins that contain one or more RDD sites although the
RDD-containing peptides were not necessarily detected. Among the 659 proteins, we detected
299 and 28 peptides encoded by the DNA and RNA forms of RDDs (Table S5). As shown in
Table 3 of main text, 17 pairs of peptides differ in one residue that corresponded to the RNA and
DNA variants at RDD sites. A RDD site in RPL28 led to a loss of a STOP codon and resulted in
a larger protein with additional amino acids. We carried out BLAST search and ensured that all
28 peptides that correspond to the RNA forms of the RDD-containing peptides are unique to the
proteins of interests. For these alignments, we used nr to search all nonredundant sequences
(which includes CDS translations+PDB+SwissProt+PIR+PRF). All 28 RDD sites correspond to
monomorphic sites; by Sanger sequencing of the same aliquot of B-cells used for mass
spectrometry, we validated the sequences correspond to the reference genome sequence (Table
S8).

13

TableS1.CharacteristicsofRNAseqsamplesanddistributionofeventsbyindividual

ID
GM06985
GM06994
GM07000
GM11829
GM11830
GM11831
GM11832
GM11881
GM11992
GM11993
GM11994
GM12003
GM12004
GM12005
GM12006
GM12043
GM12044
GM12144
GM12155
GM12716
GM12717
GM12750
GM12762
GM12813
GM12814
GM12872
GM12874
Total
Mean

Gender
F
M
F
M
F
M
F
M
M
F
M
M
F
M
F
M
F
M
M
M
F
M
M
F
M
M
M

Totalreads
38424688
37634150
36665036
37293182
36412185
38923882
38657782
49771575
63260299
38441615
42390584
36977676
28390919
45286259
35506222
36999366
39839492
35020229
43551373
46656852
40635780
45066631
47651198
45288662
39024182
45367154
39588081

Uniquelymapped
reads
24864586
31439915
26987933
28117279
26729286
26175492
27779737
29645009
41104692
27190601
27741424
29073057
21836374
25260540
28101550
27453229
30992207
21561396
33153306
30454296
32974555
31480502
31766092
34565796
29109410
17499200
20781628

Bases10
coverage
16038399
19979779
16357700
16305573
16388938
16683852
16629265
15899948
17703651
15681535
16702144
17727318
13369507
11909776
14554102
17312508
16088150
11631101
16821880
16024579
20054384
17290976
17761776
18137367
16700518
9290271
10406285

DNA
coverage
2.6
4.6
4.1
6
6.4
6.4
2.8
5.1
5.7
3.7
13.8
5.9
6.2
6.1
3.3
4.2
4.7
5.5
11.7
5.9
5.2
4.2
2.2
3.7
4.7
4.9
4.9

1108725054
41063891

763839092
28290337

429451282
15905603

144.5
5.4

14

Numberofevents
Homozygous
Monomorphic
SNPs
sites
14
394
36
1208
45
1512
17
1011
31
938
29
965
27
956
29
1462
53
1810
12
621
18
466
46
1384
6
480
20
1248
34
1070
26
728
40
1255
45
1334
9
273
45
1358
25
1339
32
1319
22
819
35
1179
28
996
42
927
29
919
795
29

27971
1036

Total
408
1244
1557
1028
969
994
983
1491
1863
633
484
1430
486
1268
1104
754
1295
1379
282
1403
1364
1351
841
1214
1024
969
948
28766
1065

Table S2. Genomic DNA sequences verified by Sanger sequencing.

Gene

RDD

Location

genomicDNA(Sanger)

CD22

TtoG

chr19:40514815

DFNA5

TtoA

chr7:24705225

ENO1

TtoC

chr1:8848125

FH

TtoA

chr1:239747217

HMGB1

TtoA

chr13:29935772

HMGB1

AtoC

chr13:29935469

ITPR3

AtoC

chr6:33755773

RAD50

TtoG

chr5:131979610

ROD1

GtoT

chr9:114026264

RPL32

GtoT

chr3:12852658

RPS25P8

AtoG

chr11:118393375

RPS3AP47

CtoA

chr4:152243651

SUPT5H

GtoT

chr19:44655806

TOR1AIP1

TtoC

chr1:178144365

TUBA1

AtoG

chr2:219823379

* RDD sites are those that were found as RNA forms in peptides (mass spectrometry analysis).
We sequenced DNA extracted from the pooled samples of cell extracts used in the mass
spectrometry analysis. Sanger sequencing verified that all the sites are monomorphic; the results
agree with the sequencing data from the 1000 Genomes and Human Genome Projects (as shown
in the UCSC Genome Browser for the reference genome).

15

TableS3

Table S3. EST clones that contain RDD alleles

Gene

Chr
1

Position (bp)

EST evidence

Type
AtoC

DCP1A

53,297,343

AU152901 (teratocarcinoma),
DA808260 (brain), BX100388 (liver spleen)

EIF4G3
HSP90AB1

1
6

21168555

no EST found

44,328,823

BQ355193 (head neck), BX413896 (B cells)

KDELR1

19

53584669

BU543348(prostate),CF995267(chondrosarcoma)

AtoC

LSP1

11

1,870,029

AI217606 (fetal heart), AI950527 (squamous cell carcinoma)

AtoC

NADK
NPEPPS

1674121
43055387
11037319
40082465

no EST found

17

CA450360 (lung), BQ575372 (chondrosarcoma)

AtoC
AtoC

no EST found
BF367406 (placenta)

AtoC
AtoC

CD359333 (testis), BF475970 (prostate)

AtoG

DB116616 (thymus), DB026916 (testis)

AtoG

CLSTN1

SRM
TRIT1

1
1

AZIN1

BLCAP

20

EIF2AK2

FLNB

MLEC

MPDU1

12
17

9712103

103910812*
35580977#

37181512, 37181517*, 37181520 no EST found

DB275343 (uterus), DA233151(brain)
58116831*

119623907
7431312

PPIA

44808624*

SLC16A1
SURF4

1
9

UBE2J2

113256882
135219393
1181354

AK2

ANKRD10

13

B2M

15

33247070
110344637
42791020

CNBP

130,372,812

COX6A1

12

EEF1G

11

FBXO42

MALAT1

11

PPP3CB

10

RNF2

119362764
62083794
16514300
65026864
74876339
183327390

GSTP1

11
5

HIGD2A
HINT1

no EST found
CA406137 (adipose), BU527340 (epidermoid carcinoma)
BM929405 (eye), BM909254 (astrocytoma)
no EST found
CD513428 (brain), CB159710 (liver)
no EST found

AtoC
AtoC

AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG

CK725144 (bone), BQ086338 (pancreatic islet)

AtoT

no EST found
AV733993 (pheochromocytoma), CK002538 (brain)

AtoT

AtoT

EL955109 (eye), BJ995106 (hepatoblastoma)

AI092730 (heart), AI290411 (placenta)

AtoT

BX393801 (neuroblastoma), BX378319 (placenta)

AtoT

no EST found

AtoT

no EST found

AtoT

no EST found

AtoT

CN265767 (ES)

AtoT

67,110,698

AA701043 (pineal), BP425295 (intestine)

DN999057 (bone marrow), EC557582 (prostate)

CtoA
CtoA

175749358
130522885

MX1
MYL6

21
12

41,753,010
54,841,626

PDCL3

RPL3

22

RPS3A

ST13

22

100554512
38038834
152240239
39558576

VDAC2

10

AA826846 (prostate)
BP387195 (pancreatic islet), CA307542 (macrophage)
EC496428 (prostate), BG030232 (breast adenocarcinoma)
CD103783 (skin), AW955784 (colon tumor)

AtoT

CtoA
CtoA
CtoA
CtoA

CA305940 (macrophage), CD106758 (brain)

CtoA

CR991113 (T-cells), DW429987 (liver)

no EST found

CtoA

76,661,042

BP197712 (adrenal), BX364042 (B cell)

CtoA

DB293877 (endothelial cells), DB276783 (uterus)

FN155323 (breast carcinoma), DW465469 (liver)

CtoG

ARID1A

26971890

B2M

15

42,791,002

COMT

22
19

18,336,272

AI797179 (carcinoid), BX339791(placenta)

CN364748 (ES), BX455397 (brain)

CYTH2

AtoC

H2AFX

11

53673135
118470179

NDUFC2
RBM23

11
14

77,468,303
22,440,217

RPLP1

15

no EST found
DB105510 (thymus), EL950726 (eye)

CtoA

CtoG
CtoG
CtoG
CtoG

BQ232763 (testis, embryonic)

DW467524 (liver), CK001450 (brain)

CtoG
CtoG
CtoG

no EST found

CtoG

no EST found

CtoG
CtoT

SFRS5

14

SNRPE

67532211
69303847
202099467

CTBP2
DPP7

10
9

126672506

AA309267 (hepatocellular carcinoma), AW961838 (colon)

139,128,755

GON4L
NDUFS5

1
1

PRDM2

154020201
39264595
13986214

DB282304 (uterus), DB083627 (testis)

BI114125 (rhabdomyosarcoma), DA569196 (embryonic tissues)

RPL23

17

34,263,515

BP206252 (smooth muscle), CK128791 (embryonic stem cell)

CtoT

SLC25A1
SLC25A1

22
22

17,543,578

BY798887 (eye), BX383114 (T cell)

17543578

BY798887 (eye), BX407174 (palcenta)

CtoT
CtoT

DW435173 (liver), BM738465 (lymphoblast)

no EST found

16

CtoT
CtoT
CtoT
CtoT

TableS3

TUBB2B

3,169,822

no EST found

UBE2G2

21

45015596

BI253788 (cervical carcinoma)

CtoT
CtoT

BF972964 (leiomyosarcoma), BE881159 (lung carcinoma)

BY995830 (mast cell), CB055134 (glioblastoma)

GtoA

BLNK

10

97,957,645

CARHSP1

16

8,856,270

GtoA

DUSP

10

112,261,285

no EST found

GtoA

FBX044

11641457

no EST found

GtoA
GtoA

FIBP

11

65,407,967

CD017568 (hemapoietic stem cell), CB306355 (epithelium)

GPX1

49,369,615

BP389951 (pancreatic islet), BP294983 (macrophage)

HLA-DQB2

32,833,537, 32,833,545, 32,833,537 no EST found

CT000835 (T cell), AU310615 (neuroblastoma)
44,571,683

GtoA
GtoA, GtoA, CtoT
GtoA

PFKL

21

RHOT1
TAF5L

17
1

27,526,465

BQ345807 (nerve tumor)

227805007

BF091853 (testis), AW170566 (cervix)

GtoA
GtoA

C17orf70

17

77,117,583

AA625546 (melanocyte), AA564879 (prostate)

GtoC

CCDC88B

11
12

63873710
131927447
126717637
93587286
124957509
29934680
89326052
55055410
57787551

No EST found

GtoC
GtoC

70837047
131858545
26674349
52962537
232808841
45749309
54999230
3801714
22440250
55036254

BX383615 (T cells)
no EST found

14986231
30977905
52159874
74876340
52655038
149501330
129926756
45017000
70534516
70601993

AW893953 (nerve), AW513645 (granulosa tumor)

no EST found

TtoA

BG204392 (sarcoma), BG200284 (sarcoma)

TtoA
TtoA

30336961
26499056
62216686
41249976
26674233
32572034
101786358
31177027
92700130
28763847

CT000809 (T-cells), CT003894 (T-cells)

TtoC

AI254396 (ovarian carcinoma), AA527650 (sarcoma)

no EST found

TtoC

DA829334 (placenta), BG754228 (B-cells)

DA923318 (intestine), CA395907 (retina)

TtoC

61316640
57184884
62156790

CD685627 (nasopharynx), BU960944 (mixed cell types)

TtoG

BI856612 (mammary adenocarcinoma),

TtoG

DC409644 (thymus), DC335243 (hippocampus)

TtoG

no EST found

TtoG

no EST found

TtoG

no EST found

TtoG

CF124792 (T cell), DW459229 (liver)

TtoG

CHFR

CTBP2

10

DDX24

14

EI24

11

HMGB1
PRC1

13
15

PTOV1

19

ZWINT

10

DHCR7
GOLGA3
HMGN2
HNRNPA1P2
IRF2BP2
MMACHC/PRDX1
PAN2
PGAP2
RBM23
STAT2

11

ARHGDIB
LAPTM5
PCBP2
PPP3CB
PRPF38A
PSMD4

12

RAN

12
1

RPS8
SRGN
VPS26A
AL662795
BTN2A2

12
1
12
1
1
12
11
14
12

1
12
10
1
1

10
10
6
6

COMMD1

CTPS
HMGN2

1
1

MARCKSL1
PABPCP5

PUM1
SYK

1
9

TRNAU1AP

C11orf10

11

CLP1

11

GANAB

11

HK1

10

MDM4

PRPF3

70831630
202789468
148571780

RPL37

40,871,072

BI262008 (lymphoma), BF736510 (bladdar tumor)

CD106509 (pituitary)
No EST found

GtoC
GtoC

No EST found

GtoC

AU128946 (teratocarcinoma), CB267551 (adipose)

GtoC
GtoC

CN348404 (ES), BF969637 (adrenal cortex carcinoma)

EL953342(eye),EC536111(prostate)

GtoC

No EST found

GtoC

BX388386 (neuroblastoma), BE091398 (breast)

BM083591 (large cell carcinoma), BE882415 (leiomyosarcoma)

GtoT
GtoT
GtoT

BM994807 (chondrosarcoma), BE062504 (breast)

GtoT
GtoT

BU934412 (pooled), BY999091 (epithelium)

no EST found

GtoT

no EST found
BQ232763 (testis)
no EST found

DA791456 (brain), BP377586 (uterus)

no EST found

GtoT
GtoT
GtoT
GtoT

TtoA

TtoA

no EST found

TtoA

BP389950 (pancreas)

TtoA
TtoA

BY998701 (epithelium), DT220983 (brain)

no EST found
CD678067 (bone), AA093598 (heart)

no EST found
CB145560 (liver), BQ647981 (hepatocellular carcinoma)
no EST found

TtoA
TtoA

TtoC
TtoC
TtoC
TtoC

BE181981(head,neck)

TtoC

no EST found

TtoC
TtoC

17

TableS3

RPS2

16

1,954,544

BU175665 (lung carcinoma), BQ672658 (epidermoid carcinoma)

SLAMF6

CD635370 (not specified),

TtoG
TtoG

TPM3

158759594
152412239

BI020350 (bone marrow), AW800178 (uterus)

TtoG

For most sites, we found multiple ESTs that contain the RNA-forms of the RDD sites, we listed two per site as examples.
Reported in Reidmann et al, 2008

* Also identified by Li, Levanon et al, 2010.

All sites listed are monomorphic sites in the genome (except DPP7) thus the genomic sequences of the ESTs should be the same as the reference sequence.

18

Table S4. Mass spectrometry data in ovarian cancer cells (A) and leukemia cells (B) detected peptides encoded by DNA
or RNA sequences (underlined) at multiple RDD sites.
A. Peptides detected form HOC-7 ovarian cancer cell line
AA
Protein
Location*
RDD
DNA form peptide
change
STOP-toN/A
RPL28*
chr19:60590467 T-to-A
R
TUBA1
chr2:219823379 A-to-G E-to-G
EDMAALEK
HSPA4
chr5:132459768 T-to-G
HSP90AB1 chr6:44328823 A-to-C

V-to-G
T-to-P

B. Peptides detected form K562 leukemia cell line

AA
Protein
Location*
RDD
change

RNA form peptide

SLIGTASEPR
EDMAALGK

TSTVDLPIENQLLWQIDR
LVSSPCCIVTSTYGWTANMER

TSTGDLPIENQLLWQIDR
LVSSPCCIVTSTYGWPANMER

DNA form peptide

RNA form peptide

DHX15

chr4:24187092

T-to-A

Y-to-N

YYDILK

NYDILK

ENO3

chr17:4800624

T-to-G

V-to-G

N/D

LAQSNGWGGMVSHR

N/D
HNRNPA3
chr2:177789664 T-to-C
S-to-P
N/D
HNRNPL
chr19:44021390 C-to-A
Q-to-K
AITHLNNNFMFGQK
MYH10
chr17:8357846
T-to-G W-to-G
N/D
RANBP2
chr2:108765620 T-to-A
I-to-K
ITMELFSNIVPR
USP34
chr2:61329192
T-to-A
Y-to-N
N/D
ZFP91
chr11:58138282 A-to-G
H-to-R
N/D
* hg 18 of human genome build. (N/A- not applicable; N/D - not detected)
FABP3

chr1:31618424

T-to-A

W-to-R

19

MVDAFLGTR
GGGPGNFMGR
AITHLNNNFMFGKK
HWQWGR
KTMELFSNIVPR
LDMTPNTEDFLMGK
YLQHRIK

Table S5.Peptides encoded by DNA or RNA sequences at the RDD sites were detected in mass
spectrometry analysis of cultured B-cells.
Protein
AP2A2
AP2A2
DFNA5
DFNA5
ENO1
ENO1
ENO3
ENO3
FABP3
FABP3
FH
FH
HMGB1
HMGB1
NACA
NACA
NSF
NSF
POLR2B
POLR2B
RAD50
RAD50
RPL12
RPL12

RDD site
chr11:976858
chr11:976858
chr7:24705225
chr7:24705225
chr1:8848125
chr1:8848125
chr17:4800624
chr17:4800624
chr1:31618424
chr1:31618424
chr1:239747217
chr1:239747217
chr13:29935772
chr13:29935772
chr12:55392932
chr12:55392932
chr17:42161411
chr17:42161411
chr4:57567852
chr4:57567852
chr5:131979610
chr5:131979610
chr9:129250509
chr9:129250509

RDD
T-to-G
T-to-G
T-to-A
T-to-A
T-to-C
T-to-C
T-to-G
T-to-G
T-to-A
T-to-A
T-to-A
T-to-A
T-to-A
T-to-A
G-to-A
G-to-A
T-to-C
T-to-C
T-to-A
T-to-A
T-to-G
T-to-G
A-to-G
A-to-G

RPL28
RPL32
RPL32
RPS3AP47
RPS3AP47
SLC25A17
SLC25A17
TUBA1
TUBA1
TUBB2C
TUBB2C
HMGB1
TOR1AIP1
RPS25P8
CD22
SUPT5H
ITPR3
CDC2L5
ASAH1
POP1
ROD1
PGD
CAPZA1
PSMD4
PSMD4

chr19:60590467
chr3:12852658
chr3:12852658
chr4:152243651
chr4:152243651
chr22:39520485
chr22:39520485
chr2:219823379
chr2:219823379
chr9:139257297
chr9:139257297
chr13:29935469
chr1:178144365
chr11:118393375
chr19:40514815
chr19:44655806
chr6:33755773
chr7:40094317
chr8:17965017
chr8:99237725
chr9:114026264
chr1:10395757
chr1:113011240
chr1:149501316
chr1:149503099

T-to-A
G-to-T
G-to-T
C-to-A
C-to-A
A-to-G
A-to-G
A-to-G
A-to-G
G-to-A
G-to-A
A-to-C
T-to-C
A-to-G
T-to-G
G-to-T
A-to-C
A-to-G
C-to-A
T-to-G
G-to-T
A-to-C
A-to-G
G-to-A
A-to-G

AA
change
Y-to-D
Y-to-D
L-to-Q
L-to-Q
L-to-P
L-to-P
V-to-G
V-to-G
W-to-R
W-to-R
I-to-K
I-to-K
Y-to-N
Y-to-N
D-to-N
D-to-N
V-to-A
V-to-A
L-to-Q
L-to-Q
L-to-R
L-to-R
N-to-D
N-to-D
STOPto-R
A-to-S
A-to-S
T-to-K
T-to-K
E-to-G
E-to-G
E-to-G
E-to-G
G-to-D
G-to-D
K-to-N
S-to-P
N-to-D
L-to-R
Q-to-H
D-to-A
M-to-V
H-to-N
C-to-G
G-to-V
T-to-P
N-to-D
A-to-T
T-to-A

Detected peptide
DLALESMCTLASSEFSHEAVK
YLALESMCTLASSEFSHEAVK
VFPQLLCITLNGLCALGR
VFPLLLCITLNGLCALGR
EGPELLK
EGLELLK
LAQSNGWGGMVSHR
LAQSNGWGVMVSHR
MVDAFLGTR
MVDAFLGTWK
KEYDTFGELK
IEYDTFGELK
MSSNAFFVQTCR
MSSYAFFVQTCR
NIELVMSQANVSR
DIELVMSQANVSR
LLDYAPIGPR
LLDYVPIGPR
IISDGQK
IISDGLK
WRQDNLTLR
WLQDNLTLR
HSGDITFDEIVNIAR
HSGNITFDEIVNIAR

Coded
by
RNA
DNA
RNA
DNA
RNA
DNA
RNA
DNA
RNA
DNA
RNA
DNA
RNA
DNA
RNA
DNA
RNA
DNA
RNA
DNA
RNA
DNA
RNA
DNA

SLIGTASEPR
SAQLAIR
AAQLAIR
EVQKNDLK
EVQTNDLK
TTHMVLLGIIK
SKTTHMVLLEIIK
EDMAALGK
EDMAALEK
LHFFMPDFAPLTSR
LHFFMPGFAPLTSR
TMSAKEN
QPSVLSPGYQK
EVPDYK
MHLLGPWLLLR
TPMYGSQTPLHDGSR
DGVEDHSPLMYHISLVALLAACAEGK
QMGVTDDVSTIK
GIAAVTDIPLGNLIHGR
EAEEVMDAGGQESAGPER
NLFIEAVCSVK
TELDSFLIEITANILK
IQVHYYEDGNVQLVSHK
LQAQQDAVNIVCHSK
ITFCTGIR

RNA
RNA
DNA
RNA
DNA
RNA
DNA
RNA
DNA
RNA
DNA
RNA
RNA
RNA
RNA
RNA
RNA
RNA
RNA
RNA
RNA
DNA
DNA
DNA
DNA

20

PSMD4
RAB13
TPM3
TPM3
TPM3
ADAR
ARHGEF2
COPA
ALDH9A1
UBR4
KIAA0090
AKR7A2
PTPRC
SNRPE
RAB3GAP2
GALNT2
RPL11
C1orf128
FAM36A
KPNA6
NDUFS5
MACF1
MACF1
TOE1
ENO1
ENO1
ENO1
ENO1
ENO1
ENO1

chr1:149505434
chr1:152225281
chr1:152412062
chr1:152412239
chr1:152422191
chr1:152828520
chr1:154188626
chr1:158571656
chr1:163931204
chr1:19354011
chr1:19418760
chr1:19505140
chr1:196970974
chr1:202099460
chr1:218450777
chr1:228438406
chr1:23891686
chr1:23984835
chr1:243071920
chr1:32405361
chr1:39267183
chr1:39591327
chr1:39669016
chr1:45580673
chr1:8844063
chr1:8845549
chr1:8846682
chr1:8850693
chr1:8854615
chr1:8857500

A-to-C
T-to-C
T-to-C
T-to-G
T-to-G
A-to-G
T-to-C
T-to-G
T-to-G
T-to-G
T-to-C
T-to-C
T-to-A
T-to-A
T-to-C
T-to-G
C-to-G
G-to-A
C-to-G
T-to-G
T-to-C
T-to-C
T-to-C
A-to-C
G-to-T
T-to-A
A-to-C
T-to-C
G-to-C
A-to-G

ABCD3
ACTR1A
SMC3
BMS1
TFAM
DDX21
VPS26A
PPA1
AASDHPPT
RPS25P8
RPS25P8
SAAL1
NAP1L4
COMMD9
TUT1
TUT1
TUT1
TUT1
GANAB
PPP1R14B
IPO7
ARL1
HSP90B1

chr1:94736821
chr10:104231754
chr10:112350812
chr10:42617671
chr10:59815388
chr10:70398756
chr10:70592265
chr10:71644307
chr11:105467314
chr11:118393360
chr11:118393425
chr11:18061854
chr11:2953860
chr11:36254337
chr11:62083776
chr11:62083844
chr11:62090860
chr11:62090860
chr11:62150937
chr11:63770495
chr11:9420282
chr12:100320831
chr12:102861072

G-to-T
T-to-C
A-to-C
T-to-G
T-to-G
A-to-G
A-to-T
T-to-G
T-to-A
A-to-C
T-to-C
T-to-A
T-to-C
T-to-G
C-to-G
G-to-T
C-to-G
C-to-G
A-to-C
T-to-C
A-to-G
T-to-C
G-to-A

T-to-P
V-to-A
V-to-A
I-to-S
V-to-G
E-to-G
V-to-A
H-to-Q
V-to-G
I-to-S
Y-to-H
S-to-P
D-to-E
I-to-K
F-to-L
V-to-G
Q-to-E
G-to-E
H-to-D
V-to-G
L-to-S
V-to-A
V-to-A
T-to-P
E-to-D
Y-to-N
T-to-P
V-to-A
V-to-L
T-to-A
E-toSTOP
F-to-L
T-to-P
D-to-E
C-to-W
Q-to-R
T-to-S
C-to-W
L-to-H
T-to-P
L-to-S
V-to-E
V-to-A
W-to-G
A-to-G
W-to-C
P-to-R
P-to-A
T-to-P
L-to-P
D-to-G
V-to-A
A-to-T

MTISQQEFGR
LLLIGDSGVGK
LVIIEGDLER
MELQEIQLK
MAGITTIEAVK
GETVNDCHAEIISR
DLLVGPGVELLLTPR
TTFFHHEYPWILSASDDQTIR
EVNLAVQNAK
TTLEVLQLFPINIK
EENLIPYSPDVQIHAER
ALQAAYGASAPSVTSAALR
CPDYIIQK
IEGCIIGFDEYMNLVLDDAEEIHSK
FYTENGVLLLAQLLNEDPVLQLK
VDLPATSVVITFHNEAR
MAQDQGEK
DLTGELEYATK
HSILYGSLGSVVAGFGHFLFTSR
AQIQAVIDANIFPVLIEILQK
IEYDDFVECLLR
IDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEK
LVLDTVNEVSR
TLFLELIR
IEEELGSK
YNQLLR
FTASAGIQVVGDDLTVTNPK
LNVTEQEK
AAVPSGASTGIYEALELR
GNPTVEVDLFTSK

DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA

VLGELWPLFGGR
TLFSNIVLSGGSTLFK
ETEGGTVLTATTSELEAINK
VLAEDEELYGDFEDLETGDVHK
SGAELCTGCGSR
DSEDNPQTLLFSATCPHWVFNVAK
EITGIGPSTTTETETIAK
HTGCCGDNDPIDVCEIGSK
LEFDLSPLNLDIGQVYK
LITPAVVSER
LNNLVLFDK
VDLPLIDSLIR
LDNVPHTPSSYIETLPK
LVDLDWR
EYFSWEGAFQHVGK
GQELAFPLSPDWQVDYESYTWR
DPFAHLPK
TPSLTCPR
HHGPQTLYLPVTLSSIPVFQR
LNLEEWILEQLTR
QLQDIATLADQR
LQVGEVVTTIPTIGFNVETVTYK
GYEVIYLTEPVDEYCIQALPEFDGK

DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA

21

HSP90B1
HSP90B1
RPL6P10
RPL6P10
RAB35
RPLP0P3
RPLP0P3
ETV6
UBC
HNRNPA1P2
STAT6
NCAPD2
RPL21
LCP1
KPNA3
HSP90AA2
HSP90AA2
HNRNPC
PSME2
PSME2
PSME2
PSME2
GPHN
ACYP1
CYFIP1
CYFIP1
AQR
FAM82A2
MYO5A
SLTM
PTPLAD1
ANP32A
ANP32A
ANP32A
ANP32A
CTSH
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RBBP6
GTF3C1
MRPL28
GLG1
PRPSAP2
TMEM97
RPL23A
RPL23A
RPL19P12
RPL19P12

chr12:102861093
chr12:102861718
chr12:111328141
chr12:111328215
chr12:119026056
chr12:119119095
chr12:119119539
chr12:11928688
chr12:123963624
chr12:52962536
chr12:55784520
chr12:6505902
chr13:26728451
chr13:45630661
chr13:49204900
chr14:101617878
chr14:101620494
chr14:20771963
chr14:23682660
chr14:23682668
chr14:23683244
chr14:23684195
chr14:66705421
chr14:74599948
chr15:20515200
chr15:20551650
chr15:32973226
chr15:38817134
chr15:50400922
chr15:56972482
chr15:63636158
chr15:66863951
chr15:66866825
chr15:66866841
chr15:66867257
chr15:77002465
chr16:1952264
chr16:1952501
chr16:1952579
chr16:1952779
chr16:1952844
chr16:1952872
chr16:1954304
chr16:24488024
chr16:27421714
chr16:357701
chr16:73198103
chr17:18721825
chr17:23670508
chr17:24072035
chr17:24074747
chr17:34611017
chr17:34613861

A-to-G
T-to-G
A-to-G
T-to-C
T-to-G
C-to-A
A-to-T
A-to-C
A-to-T
A-to-C
G-to-T
T-to-C
T-to-G
T-to-G
T-to-A
C-to-T
A-to-C
G-to-T
A-to-T
T-to-C
C-to-G
G-to-C
T-to-G
T-to-C
T-to-C
A-to-G
T-to-G
T-to-C
T-to-G
A-to-G
T-to-A
A-to-G
T-to-C
A-to-G
T-to-C
T-to-G
A-to-C
T-to-C
C-to-T
T-to-C
C-to-T
C-to-G
A-to-T
T-to-C
T-to-C
T-to-G
T-to-G
A-to-C
A-to-C
A-to-G
C-to-G
G-to-C
A-to-C

K-to-E
S-to-A
N-to-D
V-to-A
W-to-G
S-to-Y
E-to-V
D-to-A
E-to-V
R-to-S
Q-to-H
I-to-T
W-to-G
S-to-A
L-to-Q
T-to-I
Y-to-S
G-to-V
M-to-L
L-to-P
S-to-C
C-to-S
V-to-G
V-to-A
L-to-P
K-to-R
V-to-G
L-to-P
V-to-G
K-to-E
V-to-E
N-to-S
L-to-P
N-to-D
L-to-P
V-to-G
T-to-P
F-to-S
P-to-L
W-to-R
A-to-V
L-to-V
I-to-F
Y-to-H
V-to-A
V-to-G
W-to-G
Y-to-S
Y-to-S
K-to-R
L-to-V
A-to-P
H-to-P

GYEVIYLTEPVDEYCIQALPEFDGKR
LTESPCALVASQYGWSGNMER
IDISNVK
QLASGLLLVTGPLVLNR
LQIWDTAGQER
AFLADPSAFVAAAPVAAATTAAPAAAAAPAK
VLALSVETDYTFPLAEK
LLWDYVYQLLSDSR
ESTLHLVLR
QEMASASSSQRGR
LPIQLQALSLPLVVIVHGNQDNNAK
GFVHPDPLWIPFK
GTWVQLK
EGICAIGGTSEQSSVGTQHSYSEEEK
AQNVTLEAILQNATSDNPVVQLSAVQAAR
LGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSR
VFIMDNCEELIPEYLNFIR
MIAGQVLDINLAAEPK
AMVLDLR
DEAAYGELR
VEAFQTTISK
CGFLPGNEK
IIFALPGNPVSAVVTCNLFVVPALR
VQGVFFR
HVQLLGR
VQKHDGK
TDVAVQIISNIYHNFPEQR
TATALLESPLSATVEDALQSFLK
QVLSDLAIQIYQQLVR
KEILPFEK
QVNITVQK
SLDLFNCEVTNLNDYR
DLSTIEPLK
CPNLTHLNLSGNK
LEGLTDEFEELEFLSTINVGLTSIANLPK
VNHAVLAVGYGEK
ATFDAISK
GCTATLGNFAK
GTGIVSAPVPK
GYWGNK
EVATAIR
AFVAIGDYNGHVGLGVK
SLEEIYLFSLPIK
EWYEK
NLIIEAVTNLR
IYVAELIQQLQQQALSEPAVVQK
HTWSNNLAVLECLQDVR
SIIGVIPYFPYSK
ELYPVEFR
NKLDHYAIIK
LAPDYDALDVANK
LASSVLR
HMYHSLYLK

22

DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA

RPL19P12
TOP2A
NPEPPS
PNPO
PHB
PHB
NME2
NME2
MAP2K6
SUMO2
PFAS
PFAS
RPL26
MYL12A
MYL12B
MYL12B
RPL17P20
RPL17P20
RPL17P20
CNDP2
GCDH
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPL

chr17:34613921
chr17:35818397
chr17:43046067
chr17:43377042
chr17:44845585
chr17:44845601
chr17:46603858
chr17:46603942
chr17:65031300
chr17:70688860
chr17:8098256
chr17:8109640
chr17:8226270
chr18:3245809
chr18:3262970
chr18:3267804
chr18:45270826
chr18:45270875
chr18:45271908
chr18:70331924
chr19:12865307
chr19:44020924
chr19:44021073
chr19:44026546
chr19:44026579
chr19:44028541
chr19:44029800

A-to-C
T-to-G
A-to-G
T-to-A
T-to-C
A-to-G
A-to-G
C-to-A
T-to-C
A-to-G
T-to-G
A-to-C
G-to-T
G-to-A
T-to-C
A-to-G
T-to-A
G-to-T
C-to-T
A-to-C
T-to-G
C-to-A
C-to-T
C-to-G
A-to-T
A-to-G
A-to-G

RPS16P1
HNRNPUL1
PAFAH1B3
OPA3
RPL13A
RPL13A
RPL13A
PDCL3
PDIA6
PDIA6
UGCGL1
MCM6
DARS
MTX2
HNRNPA3
HNRNPA3
STAT1
ANKRD44
HSPE1
HSPE1
BZW1
EEF1B2
TUBA1
TUBA1
TUBA1
DNPEP

chr19:44616012
chr19:46492379
chr19:47496219
chr19:50748775
chr19:54682699
chr19:54685333
chr19:54686524
chr2:100554512
chr2:10846497
chr2:10860095
chr2:128644385
chr2:136333433
chr2:136435478
chr2:176896369
chr2:177789516
chr2:177789554
chr2:191562622
chr2:197659675
chr2:198074130
chr2:198076072
chr2:201391338
chr2:206733586
chr2:219823379
chr2:219823647
chr2:219823757
chr2:219960095

T-to-G
A-to-C
A-to-G
T-to-C
A-to-C
A-to-G
G-to-A
C-to-A
T-to-G
G-to-T
T-to-G
T-to-C
T-to-G
T-to-G
T-to-G
G-to-C
T-to-G
T-to-A
A-to-G
G-to-A
T-to-C
T-to-G
A-to-G
A-to-G
T-to-G
T-to-G

H-to-P
C-to-W
T-to-A
F-to-I
L-to-P
I-to-V
H-to-R
A-to-D
C-to-R
N-to-D
F-to-V
T-to-P
K-to-N
E-to-K
M-to-T
M-to-V
L-to-H
A-to-S
P-to-L
H-to-P
C-to-W
H-to-N
S-to-F
S-to-C
D-to-V
Q-to-R
I-to-V
Y-toSTOP
N-to-T
T-to-A
V-to-A
M-to-L
I-to-V
V-to-I
H-to-N
V-to-G
V-to-L
V-to-G
S-to-P
V-to-G
F-to-V
V-to-G
G-to-R
L-to-R
D-to-E
I-to-V
G-to-D
S-to-P
V-to-G
E-to-G
S-to-G
V-to-G
V-to-G

ILMEHIHK
AAIGCGIVESILNWVK
HGDGTTLDIMLK
FFTNFESR
FGLALAVAGGVVNSALYNVDAGHR
VFESIGK
NIIHGSDSVK
SCAHDWVYE
MCDFGISGYLVDSVAK
TENNDHINLK
LMWLFGCPLLLDDVAR
APGSLVISAYAVCPDITATVTPDLK
KIMSSPLSK
FTDEEVDELYR
ATSNVFAMFDQSQIQEFK
ELLTTMGDR
NAESNAELK
SAEFLLHMLK
YSLDPENPTK
DVGAQILLHSHK
GYGCAGVSSVAYGLLAR
IQHPSNVLHFFNAPLEVTEENFFEICDELGVK
LNVCVSK
ASLNGADIYSGCCTLK
NGVQAMVEFDSVQSAQR
QALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQK
GLIDGVVEADLVEALQEFGPISYVVVMPK

DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA

ALVAYYQK
WDVLIQQATQCLNR
ELFSPLHALNFGIGGDGTQHVLWR
DEVGHLALALEALQAQVQAAPPQGALEELR
MAEVQVLVLDGR
CEGINISGNFYR
LAHEVGWK
QGIPLCALINQHLSGLAR
TCEEHQLCVVAVLPHILDTGAAGR
EVIQSDSLWLVEFYAPWCGHCQR
EGETYFDVVAVVDPVTR
ASSAAGLTAAVVR
QQQFNVQALVAVGDHASK
GEQILLSDNAASLAVQAFLQMCNLPIK
YHTINGHNCEVK
QEMQSAGSQR
LQELNYNLK
LLQSSGADFHK
GGIMLPEK
VLLPEYGGTK
ELQEQMSR
SYIEGYVPSQADVAVFEAVSSPPPADLCHALR
EDMAALEK
SIQFVDWCPTGFK
AYHEQLSVAEITNACFEPANQMVK
EAVQTAAK

DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA

23

SP100
PTMA
COPS8
LRPPRC

chr2:231016021
chr2:232285464
chr2:237663350
chr2:44055355

T-to-C
T-to-G
T-to-C
A-to-G

PSME4
SPTBN1
XPO1
RAB1A
ACTR2
SNRNP200
FKBP1A
FKBP1A
RRBP1
SEC23B
ATP5E
GART
MX1
MYH9
UNC84B
ST13
ST13
ST13
ST13
RANGAP1
CCDC58
RPL32
CNBP
NUP210
SR140
RPSA
RPSA
RPSA
RPL14
RPL14
LARP7
MAD2L1
RPS3AP47
SEPT11
COPS4
HSPA4
SKP1
DDX46
LARS
NPM1
NPM1
NPM1
NPM1
GNB2L1
AP3B1
GLRX
SOD2
GNL1
HLA-B

chr2:53999792
chr2:54730317
chr2:61582645
chr2:65178665
chr2:65327306
chr2:96307286
chr20:1304142
chr20:1304230
chr20:17565286
chr20:18461350
chr20:57038877
chr21:33822510
chr21:41733614
chr22:35028580
chr22:37467521
chr22:39558575
chr22:39561567
chr22:39561775
chr22:39566612
chr22:39982752
chr3:123569761
chr3:12852705
chr3:130372980
chr3:13370113
chr3:144228695
chr3:39425116
chr3:39425192
chr3:39427358
chr3:40474416
chr3:40475194
chr4:113793691
chr4:121206413
chr4:152243597
chr4:78152073
chr4:84206687
chr5:132459768
chr5:133524650
chr5:134190554
chr5:145489883
chr5:170747595
chr5:170751002
chr5:170751328
chr5:170770139
chr5:180597737
chr5:77460856
chr5:95178004
chr6:160023556
chr6:30630380
chr6:31431282

T-to-G
T-to-G
T-to-C
G-to-A
A-to-G
G-to-A
T-to-G
A-to-G
T-to-G
G-to-A
A-to-C
T-to-A
T-to-G
T-to-G
A-to-T
T-to-G
C-to-A
A-to-G
G-to-C
T-to-G
T-to-G
T-to-C
T-to-G
A-to-C
T-to-C
A-to-C
T-to-A
T-to-A
T-to-G
A-to-G
G-to-T
A-to-G
A-to-C
T-to-C
C-to-T
T-to-G
G-to-A
T-to-G
T-to-G
G-to-T
T-to-C
G-to-T
A-to-G
T-to-G
T-to-C
C-to-G
T-to-C
T-to-G
C-to-A

L-to-P
D-to-E
V-to-A
D-to-G
L-toSTOP
V-to-G
I-to-T
V-to-M
T-to-A
E-to-K
V-to-G
K-to-E
V-to-G
V-to-I
Y-to-S
V-to-E
V-to-G
W-to-G
E-to-V
C-to-G
A-to-D
I-to-V
D-to-H
V-to-G
N-to-K
I-to-T
D-to-E
T-to-P
L-to-P
N-to-T
S-to-R
L-to-H
V-to-G
M-to-V
A-to-S
I-to-V
Q-to-P
V-to-A
T-to-I
V-to-G
R-to-Q
V-to-G
V-to-G
R-to-M
L-to-P
G-to-V
I-to-V
C-to-G
L-to-P
T-to-R
W-to-R
V-to-G
A-to-D

TFPFLEGLR
AAEDDEDDDVDTK
DFPGIYTTINAHQWSETVQPIMEALR
DLLQIIFSFSK

DNA
DNA
DNA
DNA

GEPVTNLVPSMVSLEETK
VDTVNHLADELINSGHSDAATIAEWK
LNMILVQILK
FADDTYTESYISTIGVDFK
LNIDTR
MQLSAELQSDTEEILSK
GWEEGVAQMSVGQR
GQTCVVHYTGMLEDGKK
EQEITAVQAR
IAGAIGPCVSLNVK
QAGLSYIR
FGDPECQVILPLLK
VAVGNQPADIGYK
NWQWWR
IQEELSALR
LLGHWEEAAHDLALACK
AIEINPDSAQPYK
LAILYAK
EGVIEPDTDAPQEMGDENAEITEEMMDQANDK
QVEVINFGDCLVR
NLDDLTLLK
SYCAEIAHNVSSK
DCDLQEDACYNCGR
LHGLQAILVHEASGTTAITATATGYQESHLSSAR
NLLALIHR
SDGIYIINLK
AIVAIENPADVSVISSR
LLVVTDPR
VAYVSFGPHAGK
CMQLTDFILK
DTLAAISEVLYVDLLEGDTECHAR
GSAEIVAEFFSFGINSILYQR
TSYAQHQQVR
SLDLVTMK
LYNNITFEELGALLEIPAAK
TSTVDLPIENQLLWQIDR
RTDDIPVWDQEFLK
IYLAIESANELAVQK
ELAVEGMHR
MEDSMDMDMSPLRPQNYLFGCELK
VTLATLK
MSVQPTVSLGGFEITPPVVLR
MTDQEAIQDLWQWR
YWLCAATGPSIK
LLTQYILNLGK
DCIGGCSDLVSLQQSGELLTR
AIWNVINWENVTER
VLEMSDIVLLITDIR
CWALGFYPAEITLTWQR

DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA

24

HLA-DRB1
HLA-DQA1
HLA-DQB2
PSMB9
HLA-DPB1
RPS10
RPS10
RPL10A
RPL10A
FKBP5
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
PBEF1
ATP6V1F
ATP6V1F
AKR1B1
NUP205
HIBADH
HIBADH
CDC2L5
PPIA
PPIA
PPIA
ARPC1B

chr6:32660050
chr6:32717985
chr6:32833615
chr6:32933029
chr6:33156435
chr6:34500537
chr6:34500556
chr6:35545940
chr6:35546351
chr6:35718537
chr6:44325092
chr6:44325107
chr6:44325129
chr6:44325203
chr6:44325250
chr6:44325508
chr6:44325751
chr6:44325769
chr6:44325841
chr6:44326193
chr6:44326846
chr6:44326906
chr6:44327720
chr6:44327730
chr6:44327783
chr6:44327939
chr6:44328822
chr6:44328865
chr6:44328998
chr7:105700327
chr7:128290349
chr7:128292697
chr7:133786993
chr7:134923150
chr7:27532390
chr7:27655708
chr7:39993857
chr7:44805563
chr7:44805604
chr7:44805960
chr7:98784468

A-to-C
A-to-C
A-to-T
T-to-G
C-to-G
A-to-G
T-to-C
A-to-G
T-to-A
A-to-C
G-to-C
C-to-T
C-to-T
G-to-A
G-to-T
A-to-T
G-to-A
T-to-C
A-to-T
A-to-T
G-to-T
T-to-G
G-to-T
G-to-T
T-to-C
T-to-C
G-to-C
G-to-A
T-to-A
A-to-G
T-to-C
C-to-G
A-to-C
A-to-C
T-to-C
T-to-C
T-to-C
G-to-A
G-to-C
T-to-A
G-to-C

PABPCP5
PABPCP5
PABPCP5
PABPCP5
PABPCP5
PRKDC
PRKDC
PRKDC
RPL7
RPL7

chr8:101786343
chr8:101791093
chr8:101793816
chr8:101794519
chr8:101796895
chr8:48857348
chr8:48896783
chr8:48915208
chr8:74365987
chr8:74366353

C-to-G
T-to-A
G-to-A
G-to-T
A-to-T
T-to-G
A-to-C
T-to-C
G-to-A
G-to-T

RPL7

chr8:74367110

C-to-T

N-to-H
D-to-A
S-to-C
V-to-G
L-to-V
Y-to-C
W-to-R
K-to-R
V-to-E
T-to-P
A-to-P
R-to-C
P-to-L
V-to-I
L-to-F
E-to-V
R-to-K
L-to-P
Q-to-L
Q-to-L
K-to-N
D-to-E
S-to-I
Q-to-H
V-to-A
L-to-P
W-to-C
D-to-N
L-to-Q
H-to-R
F-to-S
I-to-M
Y-to-S
E-to-A
F-to-L
M-to-T
L-to-P
G-to-S
Q-to-H
N-to-K
W-to-C
S-toSTOP
C-to-S
E-to-K
S-to-I
E-to-V
L-to-R
T-to-P
V-to-A
G-to-E
A-to-S
R-toSTOP

YFYNQEESVR
VEHWGLDQPLLK
AQSESAQSK
VSAGEAVVNR
ATPENYLFQGR
HFYWYLTNEGIQYLR
EQFAWR
KYDAFLASESLIK
VLCLAVAVGHVK
NNEESPTATVAEQGEDITSK
ELISNASDALDK
IRYESLTDPSK
YESLTDPSK
TLTLVDTGIGMTK
ADLINNLGTIAK
HNDDEQYAWESSAGGSFTVR
ADHGEPIGRGTK
VILHLK
HSQFIGYPITLYLEK
YIDQEELNK
APFDLFENKK
VFIMDSCDELIPEYLNFIR
SIYYITGESK
EQVANSAFVER
GFEVVYMTEPIDEYCVQQLK
FENLCK
LVSSPCCIVTSTYGWTANMER
DNSTMGYMMAK
DLVVLLFETALLSSGFSLEDPQTHSNR
YDGHLPIEIK
DTTINEIEDTFR
DDIGIILINQYIAEMVR
VAIDVGYR
DLEHLMLLIGELYK
DFSSVFQFLR
TPVGFIGLGNMGNPMAK
SSLAAELNK
GSCFHR
IIPGFMCQGGDFTR
HTGPGILSMANAGPNTNGSQFFICTAK
STVLSLDWHPNNVLLAAGSCDFK

DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA

ITGMLLEIDNSELLHMLESPESLR
GFGFVCFSSPEEATK
NLDDGIDDER
GFGFVSFER
NFGEDMDDER
LGLIEWLENTVTLK
SLEYCSTASIDSENPPDLNK
ELLNPVVEFVSHPSTTCR
YGIICMEDLIHEIYTVGK
IALTDNALIAR

DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA

TEIRMAR

DNA

25

RPL7
FABP5
RPL12
RPL12
SET
SET
SET
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
TUBB2C
NUDT2
ANP32B

chr8:74367545
chr8:82358158
chr9:129251783
chr9:129252841
chr9:130493960
chr9:130494020
chr9:130494828
chr9:135205706
chr9:135206928
chr9:135206953
chr9:135206954
chr9:135207313
chr9:139257264
chr9:34333284
chr9:99800767

A-to-T
G-to-T
T-to-G
C-to-A
T-to-A
A-to-G
A-to-G
A-to-T
T-to-C
A-to-C
G-to-T
T-to-C
T-to-C
A-to-G
A-to-C

K-to-M
V-to-L
I-to-S
P-to-H
L-to-H
Q-to-R
E-to-G
N-to-Y
V-to-A
K-to-N
A-to-S
V-to-A
V-to-A
E-to-G
T-to-P

EVPAVPETLKK
ELGVGIALR
VGDDIAK
IGPLGLSPK
LNEQASEEILK
QPFFQK
VEVTEFEDIK
NFGIGQDIQPK
AGVNTVTTLVENK
KAQLVVIAHDVDPIELVVFLPALCR
AQLVVIAHDVDPIELVVFLPALCR
MGVPYCIIK
LAVNMVPFPR
TVIYWLAEVK
DISTLEPLK

26

DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA
DNA

TableS6.MostsignificantGeneOntologyEnrichmentsforGenesthatHaveRDDSites
GOGroup(MolecularFunction)
3'5'DNAhelicaseactivity
proteinbinding
catalyticactivity
RNAbinding
nucleotidebinding
ATPbinding

Examples
BLM,ERCC3,RECQL,RECQL4,WRN
ACBD3,AKT2,DENND4A,IL15,MLX
ACLY,CASP3,DHDDS,KDM2A,XRN1
APTX,BARD1,EIF1,RBM4,RNASEN
CDK2,CHD1,DARS,PIF1,U2AF1
ASS1,ATP11A,CEHK1,GART,KIF11

27

p
0
1x1079
3x1037
5x1037
4x1031
1x1022

TableS7.DistributionofRDDsitesacrossdifferentgenicregionsbytype.
5'UTR
Codingexon
3'UTR
Type
No.ofsites
%
No.ofsites
%
No.ofsites
AtoC
23
3.8
334
55.5
153
AtoG
44
1.9
984
42.3
1028
AtoT
26
7.2
148
41.2
104
CtoA
11
2.1
208
39.8
220
CtoG
17
5.8
159
53.9
79
CtoT
56
14.9
178
47.2
78
GtoA
15
2.0
342
44.9
292
GtoC
27
11.2
114
47.1
56
GtoT
43
10.8
192
48.0
110
TtoA
16
1.5
398
36.8
550
TtoC
58
2.5
953
41.8
951
TtoG
50
5.2
443
46.0
356

Mixed*
No.ofsites
92
272
81
84
40
65
113
45
55
118
316
113

%
25.4
44.2
29.0
42.1
26.8
20.7
38.3
23.1
27.5
50.8
41.7
37.0

Splicearesites2ntwithinexonborders;Poly(A)aresiteswithin30nt3'ofAAUAAAsites
*MixedmeansinsomeisoformsthesitesareincodingexonsandinotherisoformstheyareinUTRs.
PercentagesarecalculatedwithineachRDDtype.

28

%
15.3
11.7
22.6
16.1
13.6
17.2
14.8
18.6
13.8
10.9
13.9
11.7

Splice
No.ofsites
20
97
17
17
25
3
46
14
24
35
33
39

%
3.3
4.2
4.7
4.7
8.5
0.8
6.0
5.8
6.0
3.2
1.4
4.1

3'polyA
No.ofsites
%
4
0.7
174
7.5
7
1.9
77
14.7
10
3.4
4
1.1
73
9.6
2
0.8
3
0.8
90
8.3
142
6.2
25
2.6

Total
602
2328
359
523
295
377
762
242
400
1082
2278
962

TableS8.PrimersusedforamplifyingandsequencingRDDsites

PrimerName RDDsites
PrimerSequence
DPP7F
Chr9:139128755 5CAGGAGCGCTTCTTCCAGC3
DPP7R

Chr9:139128755 5CCGACACCAGGAAGCGC3

HLADQB2F1
HLADQB2R1
HLADQB2F2
HLADQB2R2
HLADQB2F3
HLADQB2R3

Chr6:32833537
Chr6:32833537
Chr6:32833545
Chr6:32833545
Chr6:32833550
Chr6:32833550
Chr2:37181512
Chr2:37181517
Chr2:37181520
Chr2:37181512
Chr2:37181517
Chr2:37181520
Chr8:103910812
Chr8:103910812
Chr20:35580977
Chr20:35580977

EIF2AK2F

EIF2AK2R

5CCTAGGGTGGTCAGACTGGA3
5TTGGGTTCCTCACCTTTCTG3
5CCTAGGGTGGTCAGACTGGA3
5TTGGGTTCCTCACCTTTCTG3
5CCTAGGGTGGTCAGACTGGA3
5TTGGGTTCCTCACCTTTCTG3
5'CCCCAAGAGCCACATGTATT3'

5'CCTCAAGCTCACTGTCACCA3'

AZIN1F
5'TACAAGGAAGATGAGCCTCTG3'
AZIN1R
5'AATAAATGGCTGGCCTCTGA3'
BLCAPF
5CCCGGCAGAGATCATGTATT3
BLCAPR
5AACAGTTTCCCCAGCAGCTA3
Chr5:64894960
PPWD1F
5AGCGATTTTCAGCAGAGACG3
Chr5:64894960
PPWD1R
5TTCCTCTTCTTGGCCAGTGT3
NDUFC2F
Chr11:77468303 5ACCAGGCCTCAAGTGGAAAC3
NDUFC2R
Chr11:77468303 5AGCCGTCGCGATCGG3

TableS8B:PrimersusedforvalidatingtheDNAsequencesofRDDsitesfoundinpeptides

PrimerName
CD22_F
CD22_R
DFNA5_F
DFNA5_R
ENO1_F
ENO1_R
FH_F
FH_R
HMGB1_F1
HMGB1_R1
HMGB1_F2
HMGB1_R2
ITPR3_F
ITPR3_R

RDDsites
Chr19:40514815
Chr19:40514815
Chr7:24705225
Chr7:24705225
Chr1:8848125
Chr1:8848125
Chr1:239747217
Chr1:239747217
Chr13:29935772
Chr13:29935772
Chr13:29935469
Chr13:29935469
Chr6:33755773
Chr6:33755773

PrimerSequence
5'CCCTGCTCAGGCTTGCACCC3'
5'GCTGCCCCCACCCTACCCTA3'
5'AGGTTTGGGATTGTGCAGCGCT3'
5'AGCCTTGGCCAGTAACACGTACT3'
5ACAGTCCCTGTGTAGCAGCTGT3
5GTCAGCCAGCTGGTCAGGCG3
5'AGGCAAGCCAAAATTCCTTCCGGA3'
5'GCCAACATTTCCACAAATGCCACT3'
5'GGAGATCCTAAGAAGCCGAGAGGCA3'
5'AGCGTCCCACTACGAGAATGCCA3'
5'TGGCATTCTCGTAGTGGGACGCT3'
5'ACGGAGGCCTCTTGGGTGCA3'
5'GTGTGACACGTGCCCCCTCC3'
5'TGTCCCCTGGCCTCCGGTTC3'

29

RAD50_F
RAD50_R
ROD1_F
ROD1_R
RPL32_F
RPL32_R
RPS25P8_F
RPS25P8_R
RPS3AP47_F
RPS3AP47_R
SUPT5H_F
SUPT5H_R
TOR1AIP1_F
TOR1AIP1_R
TUBA1_F
TUBA1_R

Chr5:131979610
Chr5:131979610
Chr9:114026264
Chr9:114026264
Chr3:12852658
Chr3:12852658
Chr11:118393375
Chr11:118393375
Chr4:152243651
Chr4:152243651
Chr19:44655806
Chr19:44655806
Chr1:178144365
Chr1:178144365
Chr2:219823379
Chr2:219823379

5'GCACTTGCTGTCACCAGTTGCC3'
5'TCTGTGCAGCAGGCTAGCAGA3'
5'TGCGGCCCAGGTAGTTGACTC3'
5'AGCGCCATTTTGCGATCTTTCCTG3'
5'TGGTGCTGGGACTCATTGCCT3'
5'TCTTCACTGCGCAGCCTGGC3'
5'AGGGAAAGGGTGCTTCTGCCA3'
5'GAGCTCCTGAAGGGCTGCCC3'
5'TGCTTCGTCTGTTCTGTGTTGGTT3'
5'CAAGGTTGTGTTGTGTGAGGAAGCA3'
5'TGGCTCCCAGACGCCCATGT3'
5'TCACCGTGACGGCGTGTTGG3'
5'ACCTGCTTTGCTGTAGGAAGTGGT3'
5'TGGGGCCCATTCCTGGGGAG3'
5'GCTGAGCAACACGACCGCCA3'
5'GCAGCAGCAGCATGAAGGGGA3'

30

TableS9

TableS9:DetailedmassspectrometrydataofpeptidesshowninTable3andFigure2.
Coded
by

Freq of
detection

Charge

Mass
(Da)

Peptide
Score

DNA

0.0064

15.91

DNA

0.0064

15.91

DNA

0.0047

11.27

DNA

0.0047

11.27

DNA

0.0047

11.27

DNA

0.0032

16.27

DNA

0.0032

16.27

RNA

-0.0562

5.07

RNA

-0.0562

5.07

DNA

0.0027

40.61

DNA

0.0027

40.61

RNA

0.0671

1.72

DNA

16

0.0008

24.95

DNA

16

0.0010

24.17

EGLELLK

DNA

16

0.0013

21.31

LtoP

EGLELLK

DNA

16

0.0016

28.48

LtoP

EGLELLK

DNA

16

0.0018

21.57

TtoC

LtoP

EGLELLK

DNA

16

0.0146

21.87

chr1:8848125

TtoC

LtoP

EGLELLK

DNA

16

0.0011

37.27

chr1:8848125

TtoC

LtoP

EGLELLK

DNA

16

0.0016

26.83

ENO1

chr1:8848125

TtoC

LtoP

EGLELLK

DNA

16

0.0145

23.26

ENO1

chr1:8848125

TtoC

LtoP

EGLELLK

DNA

16

0.0000

12.69

ENO1

chr1:8848125

TtoC

LtoP

EGLELLK

DNA

16

0.0009

26.51

ENO1

chr1:8848125

TtoC

LtoP

EGLELLK

DNA

16

0.0011

23.68

ENO1

chr1:8848125

TtoC

LtoP

EGLELLK

DNA

16

0.0013

22.95

ENO1

chr1:8848125

TtoC

LtoP

EGLELLK

DNA

16

0.0020

17.85

ENO1

chr1:8848125

TtoC

LtoP

EGLELLK

DNA

16

0.0150

24.41

ENO1

chr1:8848125

TtoC

LtoP

EGLELLK

DNA

16

0.0153

28.15

ENO1

chr1:8848125

TtoC

LtoP

RNA

0.0740

26.10

ENO3

chr17:4800624

TtoG

VtoG

DNA

0.0012

5.82

ENO3

chr17:4800624

TtoG

VtoG

DNA

0.0617

2.48

ENO3

chr17:4800624

TtoG

VtoG

DNA

0.0630

1.86

ENO3

chr17:4800624

TtoG

VtoG

RNA

0.0124

11.72

ENO3

chr17:4800624

TtoG

VtoG

RNA

-0.0034

13.17

ENO3

chr17:4800624

TtoG

VtoG

RNA

0.0110

17.19

ENO3

chr17:4800624

TtoG

VtoG

RNA

0.0129

15.35

FABP3

chr1:31618424

TtoA

WtoR

EGPELLK
LAQSNGWGVMVSH
R
LAQSNGWGVMVSH
R
LAQSNGWGVMVSH
R
LAQSNGWGGMVSH
R
LAQSNGWGGMVSH
R
LAQSNGWGGMVSH
R
LAQSNGWGGMVSH
R
MVDAFLGTWK

DNA

-0.0041

8.99

Protein

Postion (bp)

RDD

AA
change

AP2A2

chr11:976858

TtoG

YtoD

AP2A2

chr11:976858

TtoG

YtoD

AP2A2

chr11:976858

TtoG

YtoD

AP2A2

chr11:976858

TtoG

YtoD

AP2A2

chr11:976858

TtoG

YtoD

AP2A2

chr11:976858

TtoG

YtoD

AP2A2

chr11:976858

TtoG

YtoD

AP2A2

chr11:976858

TtoG

YtoD

AP2A2

chr11:976858

TtoG

YtoD

DFNA5

chr7:24705225

TtoA

LtoQ

DFNA5

chr7:24705225

TtoA

LtoQ

DFNA5

chr7:24705225

TtoA

LtoQ

ENO1

chr1:8848125

TtoC

LtoP

YLALESMCTLASSEF
SHEAVK
YLALESMCTLASSEF
SHEAVK
YLALESMCTLASSEF
SHEAVK
YLALESMCTLASSEF
SHEAVK
YLALESMCTLASSEF
SHEAVK
YLALESMCTLASSEF
SHEAVK
YLALESMCTLASSEF
SHEAVK
DLALESMCTLASSEF
SHEAVK
DLALESMCTLASSEF
SHEAVK
VFPLLLCITLNGLCAL
GR
VFPLLLCITLNGLCAL
GR
VFPQLLCITLNGLCA
LGR
EGLELLK

ENO1

chr1:8848125

TtoC

LtoP

EGLELLK

ENO1

chr1:8848125

TtoC

LtoP

ENO1

chr1:8848125

TtoC

ENO1

chr1:8848125

TtoC

ENO1

chr1:8848125

ENO1
ENO1

Detected peptide *

31

TableS9

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTWK

DNA

0.0042

4.38

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0174

12.17

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0174

13.98

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0174

18.20

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0174

7.57

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0175

13.79

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0176

15.15

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0170

10.60

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0171

11.68

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0172

15.21

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0172

9.41

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0172

9.73

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0173

20.00

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0173

11.46

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0174

11.87

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0175

17.41

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0170

13.92

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0170

11.72

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0171

10.48

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0172

8.12

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0172

7.84

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0173

9.94

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0173

9.12

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0173

11.33

FABP3

chr1:31618424

TtoA

WtoR

MVDAFLGTR

RNA

24

0.0174

12.07

FH

chr1:239747217

TtoA

ItoK

IEYDTFGELK

DNA

0.0018

23.88

FH

chr1:239747217

TtoA

ItoK

IEYDTFGELK

DNA

0.0017

20.71

FH

chr1:239747217

TtoA

ItoK

IEYDTFGELK

DNA

0.0018

19.77

FH

chr1:239747217

TtoA

ItoK

KEYDTFGELK

RNA

-0.0794

4.41

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0040

42.74

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0046

44.19

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0043

61.30

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0059

83.92

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0040

42.74

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0046

44.19

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0043

61.30

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0059

83.92

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0040

57.69

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0043

43.15

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0037

89.34

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0040

57.69

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0043

43.15

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0037

89.34

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0036

57.77

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0040

57.65

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0031

83.97

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0042

65.97

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0047

79.01

32

TableS9

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0036

57.77

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0040

57.65

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0031

83.97

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0042

65.97

HMGB1

chr13:29935772

TtoA

YtoN

MSSYAFFVQTCR

DNA

24

0.0047

79.01

HMGB1

chr13:29935772

TtoA

YtoN

MSSNAFFVQTCR

RNA

0.1614

7.61

HMGB1

chr13:29935772

TtoA

YtoN

MSSNAFFVQTCR

RNA

0.1616

8.23

NACA

chr12:55392932

GtoA

DtoN

DIELVMSQANVSR

DNA

0.0031

43.35

NACA

chr12:55392932

GtoA

DtoN

DIELVMSQANVSR

DNA

0.0047

47.45

NACA

chr12:55392932

GtoA

DtoN

DIELVMSQANVSR

DNA

0.0032

45.96

NACA

chr12:55392932

GtoA

DtoN

DIELVMSQANVSR

DNA

0.0048

58.89

NACA

chr12:55392932

GtoA

DtoN

DIELVMSQANVSR

DNA

0.0042

67.68

NACA

chr12:55392932

GtoA

DtoN

DIELVMSQANVSR

DNA

0.0043

50.81

NACA

chr12:55392932

GtoA

DtoN

NIELVMSQANVSR

RNA

-0.0562

4.50

NSF

chr17:42161411

TtoC

VtoA

LLDYVPIGPR

DNA

0.0020

20.63

NSF

chr17:42161411

TtoC

VtoA

LLDYVPIGPR

DNA

0.0020

13.99

NSF

chr17:42161411

TtoC

VtoA

LLDYAPIGPR

RNA

-0.0410

7.45

POLR2B

chr4:57567852

TtoA

LtoQ

IISDGLK

DNA

-0.0462

20.03

POLR2B

chr4:57567852

TtoA

LtoQ

IISDGLK

DNA

-0.0360

29.85

POLR2B

chr4:57567852

TtoA

LtoQ

IISDGLK

DNA

0.0122

15.88

POLR2B

chr4:57567852

TtoA

LtoQ

IISDGQK

RNA

-0.0001

21.47

RAD50

chr5:131979610

TtoG

LtoR

WLQDNLTLR

DNA

-0.1251

6.06

RAD50

chr5:131979610

TtoG

LtoR

WLQDNLTLR

DNA

0.0001

27.35

RAD50

chr5:131979610

TtoG

LtoR

WLQDNLTLR

DNA

-0.1251

6.06

RAD50

chr5:131979610

TtoG

LtoR

WLQDNLTLR

DNA

0.0001

27.35

RAD50

chr5:131979610

TtoG

LtoR

WLQDNLTLR

DNA

0.0003

23.67

RAD50

chr5:131979610

TtoG

LtoR

WLQDNLTLR

DNA

0.0003

23.67

RAD50

chr5:131979610

TtoG

LtoR

WLQDNLTLR

DNA

0.0018

28.75

RAD50

chr5:131979610

TtoG

LtoR

WLQDNLTLR

DNA

0.0018

28.75

RAD50

chr5:131979610

TtoG

LtoR

WRQDNLTLR

RNA

-0.0350

6.09

RAD50

chr5:131979610

TtoG

LtoR

WRQDNLTLR

RNA

-0.0350

6.09

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

-0.0003

15.12

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

-0.0001

43.51

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0006

28.61

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0014

33.99

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0025

21.98

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0034

57.68

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0045

41.66

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0056

45.13

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0083

100.26

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0005

23.90

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0010

46.97

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0012

30.62

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0014

23.12

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0025

37.96

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0030

38.56

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0064

94.90

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0067

15.42

33

TableS9

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

-0.0010

27.48

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0012

34.27

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0021

30.70

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0026

43.71

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0028

38.46

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0030

50.66

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0045

45.89

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0050

50.20

RPL12

chr9:129250509

AtoG

NtoD

HSGNITFDEIVNIAR

DNA

26

0.0052

105.35

RPL12

chr9:129250509

AtoG

NtoD

HSGDITFDEIVNIAR

RNA

-0.1040

35.41

RPL12

chr9:129250509

AtoG

NtoD

HSGDITFDEIVNIAR

RNA

-0.1073

36.25

RPL12

chr9:129250509

AtoG

HSGDITFDEIVNIAR

RNA

-0.1070

32.51

RPL28

chr19:60590467

TtoA

VFLRSLIGTASEPR

RNA

-0.0767

5.25

RPL28

chr19:60590467

TtoA

SLIGTASEPR

RNA

0.0245

23.02

RPL28

chr19:60590467

TtoA

SLIGTASEPR

RNA

-0.0354

22.23

RPL32

chr3:12852658

GtoT

NtoD
STOPto
R
STOPto
R
STOPto
R
AtoS

AAQLAIR

DNA

0.0014

32.24

RPL32

chr3:12852658

GtoT

AtoS

AAQLAIR

DNA

0.0018

26.72

RPL32

chr3:12852658

GtoT

AtoS

AAQLAIR

DNA

0.0015

32.83

RPL32

chr3:12852658

GtoT

AtoS

AAQLAIR

DNA

0.0010

47.84

RPL32

chr3:12852658

GtoT

AtoS

AAQLAIR

DNA

0.0014

33.36

RPL32

chr3:12852658

GtoT

AtoS

SAQLAIR

RNA

0.0009

19.13

RPS3AP47

chr4:152243651

CtoA

TtoK

EVQTNDLK

DNA

11

-0.0003

33.97

RPS3AP47

chr4:152243651

CtoA

TtoK

EVQTNDLK

DNA

11

-0.0002

20.38

RPS3AP47

chr4:152243651

CtoA

TtoK

EVQTNDLK

DNA

11

-0.0001

31.40

RPS3AP47

chr4:152243651

CtoA

TtoK

EVQTNDLK

DNA

11

-0.0001

32.71

RPS3AP47

chr4:152243651

CtoA

TtoK

EVQTNDLK

DNA

11

0.0001

16.14

RPS3AP47

chr4:152243651

CtoA

TtoK

EVQTNDLK

DNA

11

0.0003

20.72

RPS3AP47

chr4:152243651

CtoA

TtoK

EVQTNDLK

DNA

11

-0.0004

14.24

RPS3AP47

chr4:152243651

CtoA

TtoK

EVQTNDLK

DNA

11

0.0000

20.77

RPS3AP47

chr4:152243651

CtoA

TtoK

EVQTNDLK

DNA

11

0.0001

13.82

RPS3AP47

chr4:152243651

CtoA

TtoK

EVQTNDLK

DNA

11

0.0004

23.41

RPS3AP47

chr4:152243651

CtoA

TtoK

EVQTNDLK

DNA

11

0.0007

29.62

RPS3AP47

chr4:152243651

CtoA

TtoK

EVQKNDLK

RNA

-0.0429

30.42

RPS3AP47

chr4:152243651

CtoA

TtoK

EVQKNDLK

RNA

-0.0428

27.67
4.39

SLC25A17

chr22:39520485

AtoG

EtoG

TTHMVLLEIIK

DNA

-0.1446

SLC25A17

chr22:39520485

AtoG

EtoG

TTHMVLLGIIK

RNA

-0.0491

4.88

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

-0.0009

19.07

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0006

34.48

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0010

16.39

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0015

31.54

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0016

25.77

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0017

21.77

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

-0.0001

17.69

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0016

14.22

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

-0.0008

17.63

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

-0.0008

15.42

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

-0.0006

10.52

34

TableS9

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

-0.0006

27.05

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0001

12.06

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0011

32.08

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0014

26.04

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0016

14.62

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0017

18.75

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0025

17.33

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0026

20.57

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0343

8.59

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

-0.0005

15.28

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0001

9.12

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0002

15.16

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0008

15.09

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0001

16.37

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0012

30.28

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0014

12.93

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0016

26.93

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0023

21.24

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0002

13.90

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALEK

DNA

31

0.0018

17.39

TUBA1

chr2:219823379

AtoG

EtoG

EDMAALGK

RNA

0.1032

6.42

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0021

8.77

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0010

15.43

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0008

28.10

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0004

25.33

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0001

36.31

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0001

20.09

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0003

24.32

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0009

11.26

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0012

19.92

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0016

20.93

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0025

18.10

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0025

27.80

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0029

29.80

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0031

19.29

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0031

23.79

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0032

25.65

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0040

52.24

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0045

48.60

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0053

31.54

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0061

27.78

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0064

29.09

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0066

36.45

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0827

14.94

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0810

10.33

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0013

25.53

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0026

23.66

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0028

15.57

35

TableS9

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0031

16.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0037

27.26

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0041

32.68

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0057

35.72

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0065

14.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0076

23.60
14.87

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0086

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0021

8.77

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0010

15.43

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0008

28.10

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0004

25.33

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0001

36.31

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0001

20.09

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0003

24.32

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0009

11.26

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0012

19.92

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0016

20.93

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0025

18.10

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0025

27.80

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0029

29.80

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0031

19.29

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0031

23.79

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0032

25.65

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0040

52.24

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0045

48.60

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0053

31.54

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0061

27.78

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0064

29.09

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0066

36.45

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0827

14.94

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0810

10.33

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0013

25.53

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0026

23.66

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0028

15.57

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0031

16.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0037

27.26

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0041

32.68

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0057

35.72

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0065

14.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0076

23.60

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0086

14.87

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0021

8.77

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0010

15.43

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0008

28.10

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0004

25.33

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0001

36.31

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0001

20.09

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0003

24.32

36

TableS9

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0009

11.26

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0012

19.92

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0016

20.93

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0025

18.10

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0025

27.80

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0029

29.80

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0031

19.29

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0031

23.79

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0032

25.65

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0040

52.24

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0045

48.60

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0053

31.54

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0061

27.78

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0064

29.09

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0066

36.45

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0827

14.94

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0810

10.33

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0013

25.53

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0026

23.66

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0028

15.57

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0031

16.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0037

27.26

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0041

32.68

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0057

35.72

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0065

14.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0076

23.60

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0086

14.87

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0019

8.51

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0001

34.53

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0001

19.88

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0003

42.44

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0003

21.49

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0003

17.09

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0005

33.72

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0009

9.93

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0009

15.96

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0029

31.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0031

29.52

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0036

45.03

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0036

47.38

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0042

15.52

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0046

19.45

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0052

16.97

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0052

29.06

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0055

31.75

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0057

20.63

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0057

34.92

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0067

27.46

37

TableS9

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0075

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0811

32.30
9.40

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0022

21.11

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0033

24.38

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0036

50.49

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0036

20.62

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0037

12.31

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0039

22.61

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0039

34.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0052

27.70

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0299

14.64

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0019

8.51

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0001

34.53

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0001

19.88

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0003

42.44

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0003

21.49

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0003

17.09

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0005

33.72

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0009

9.93

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0009

15.96

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0029

31.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0031

29.52

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0036

45.03

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0036

47.38

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0042

15.52

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0046

19.45

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0052

16.97

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0052

29.06

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0055

31.75

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0057

20.63

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0057

34.92

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0067

27.46
32.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0075

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0811

9.40

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0022

21.11

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0033

24.38

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0036

50.49

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0036

20.62

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0037

12.31

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0039

22.61

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0039

34.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0052

27.70

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0299

14.64

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0019

8.51

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0001

34.53

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0001

19.88

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0003

42.44

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0003

21.49

38

TableS9

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0003

17.09

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0005

33.72

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0009

9.93

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0009

15.96

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0029

31.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0031

29.52

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0036

45.03

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0036

47.38

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0042

15.52

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0046

19.45

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0052

16.97

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0052

29.06

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0055

31.75

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0057

20.63

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0057

34.92

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0067

27.46
32.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0075

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0811

9.40

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0022

21.11

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0033

24.38

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0036

50.49

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0036

20.62

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0037

12.31

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0039

22.61

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0039

34.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0052

27.70

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0299

14.64

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0013

23.13

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0002

43.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0002

19.85

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0001

41.03

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0003

16.09

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0005

26.95

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0007

44.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0007

32.25

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0009

27.28

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0018

16.56

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0020

16.41

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0025

23.94

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0027

21.94

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0027

13.67

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0035

14.46

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0036

59.52

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0047

34.07

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0047

27.94

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0048

49.04

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0049

33.06

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0057

34.01

39

TableS9

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0068

27.76

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0072

30.54

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0075

24.86

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0815

12.31

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0022

21.58

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0030

21.24

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0030

12.17

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0031

21.96

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0037

24.23

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0058

47.62

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0095

12.66

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0314

26.62

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0013

23.13

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0002

43.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0002

19.85

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0001

41.03

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0003

16.09

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0005

26.95

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0007

44.30

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0007

32.25

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0009

27.28

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0018

16.56

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0020

16.41

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0025

23.94

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0027

21.94

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0027

13.67

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0035

14.46

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0036

59.52

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0047

34.07

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0047

27.94

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0048

49.04

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0049

33.06

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0057

34.01

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0068

27.76

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0072

30.54

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0075

24.86

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

-0.0815

12.31

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0022

21.58

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0030

21.24

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0030

12.17

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0031

21.96

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0037

24.23

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0058

47.62

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0095

12.66

TUBB2C

chr9:139257297

GtoA

GtoD

LHFFMPGFAPLTSR

DNA

264

0.0314

26.62

TUBB2C
chr9:139257297
GtoA
GtoD
LHFFMPDFAPLTSR
RNA
1
3
* When multiple peptides are matched to the same spectra, only the best matched peptides were retained.

0.0224

12.97

40

TableS10

TableS10.Informationon10,210exonicRDDsites

site
gene
chr15:65281199
AAGAB
chr2:69546830
AAK1
chr11:105467314 AASDHPPT
chr11:105473792 AASDHPPT
chr17:64759484
ABCA5
chr17:64758216
ABCA5
chr17:64772579
ABCA5
chr1:227732777
ABCB10
chr1:227743063
ABCB10
chr2:219783953
ABCB6
chr13:94522008
ABCC4
chr13:94628026
ABCC4
chr13:94611475
ABCC4
chr13:94470328
ABCC4
chr1:94736821
ABCD3
chr14:73829263
ABCD4
chr6:30666455
ABCF1
chr6:30666459
ABCF1
chr6:30667067
ABCF1
chr6:30667068
ABCF1
chr6:30667069
ABCF1
chr3:113188564
ABHD10
chr15:87544259
ABHD2
chr15:87544475
ABHD2
chr19:17266526
ABHD8
chr10:27080699
ABI1
chr10:27076915
ABI1
chr10:27076916
ABI1
chr2:204000148
ABI2
chr17:44649031
ABI3
chr9:132740222
ABL1
chr9:132751920
ABL1
chr10:116181193
ABLIM1
chr10:116181687
ABLIM1
chr10:116182367
ABLIM1
chr6:26707284
ABT1
chr3:128882122
ABTB1
chr16:30501419 AC002310.1
chr4:107236216 AC004053.1
chr5:132057267 AC004237.1
chr19:2222437
AC004490.1
chr19:2222438
AC004490.1
chr19:2222443
AC004490.1
chr19:2222444
AC004490.1
chr7:26379209
AC004540.2
chr22:30052353 AC005003.1
chr7:20145716
AC005062.2
chr7:30556922
AC005154.3
chr19:45016939 AC005393.1
chr19:2462261
AC005512.3
chr17:23965631 AC005726.9
chr19:2377561
AC005756.1
chr19:2377562
AC005756.1
chr19:2428671
AC005756.1
chr19:2428672
AC005756.1
chr17:46151975 AC005921.2
chr17:46183303 AC005921.3
chr17:46184267 AC005921.3
chr17:46184649 AC005921.3
chr17:46184653 AC005921.3
chr2:39534955
AC007246.1
chr2:37284893
AC007390.3
chr7:91925857
AC007566.2
chr5:140980642 AC008781.3
chr19:42545457 AC008806.1
chr16:85122790 AC009108.2
chr16:29729960 AC009133.1
chr16:29729987 AC009133.1
chr16:29729988 AC009133.1
chr16:75790975 AC009139.1
chr16:75791335 AC009139.1
chr2:95559577 AC009237.15
chr2:95559595 AC009237.15
chr2:84986290
AC010087.3
chr2:84987302
AC010087.3
chr2:84987306
AC010087.3
chr19:56013359 AC010325.3
chr19:12639888 AC010422.1
chr19:12639890 AC010422.1
chr19:12639910 AC010422.1
chr5:532527
AC010442.1
chr16:85893971 AC010531.3
chr16:11838711 AC010654.1
chr10:103576230 AC010789.3
chr2:26472064
AC010896.1
chr7:150404437 AC010973.2
chr19:6162781
AC011471.1
chr19:19764636 AC011477.2
chr19:19764653 AC011477.2
chr2:198279813 AC011997.1
chr15:48805810 AC012100.1

locationingene
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
mixed
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
mixed
mixed
mixed
mixed
mixed
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
mixed
UTR3
mixed
mixed
coding_exon
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
mixed
UTR5
UTR5
UTR5
UTR5
mixed
UTR3
coding_exon
mixed
UTR3
mixed
mixed
UTR3
UTR3
coding_exon
coding_exon

nonsynonymousaminoacidchange

strand

ENST00000278618:LtoH;
+
+
ENST00000320086:Rto*;ENST00000392676:Rto*;ENST00000392677:Rto*;

ENST00000344517:EtoD;

ENST00000376887:VtoA;ENST00000412704:VtoA;

ENST00000376887:ItoV;ENST00000412704:ItoV;ENST00000431522:ItoV;

ENST00000370214:Eto*;ENST00000394233:Eto*;ENST00000454898:Eto*;
+
ENST00000356924:ItoV;

ENST00000326195:*toG;ENST00000376545:*toG;ENST00000396515:*toG;ENST00
+
+
+
+
+
+
+
+
ENST00000247706:VtoD;

ENST00000261016:VtoA;ENST00000261017:VtoA;ENST00000261018:VtoA;ENST00
+
ENST00000225941:VtoG;ENST00000419580:VtoG;
+
ENST00000318560:LtoP;ENST00000372348:LtoP;
+
+

+
+
+
ENST00000273980:NtoD;ENST00000361687:NtoD;ENST00000394706:NtoD;ENST00

+
+
+
+
+
+
ENST00000449192:GtoE;

+
+
+
+
+
+
+
+
ENST00000324411:GtoE;ENST00000392153:GtoE;
+

+
+
+
+

+
+
+
+
+

ENST00000426336:MtoI;
+
+
+

41

type
TtoC
TtoC
TtoA
AtoG
AtoT
TtoC
AtoG
GtoT
TtoC
AtoG
TtoC
AtoG
TtoC
AtoG
GtoT
AtoG
TtoG
CtoG
GtoA
AtoC
CtoA
AtoG
AtoT
CtoT
TtoA
AtoC
CtoA
GtoA
TtoC
TtoG
TtoC
TtoA
TtoC
TtoG
TtoC
TtoC
TtoC
AtoG
AtoG
TtoC
CtoG
GtoA
CtoA
TtoG
AtoG
AtoG
GtoA
TtoC
TtoC
AtoC
TtoC
TtoC
CtoT
TtoC
CtoT
GtoA
TtoC
TtoC
TtoC
AtoG
AtoT
AtoG
AtoG
AtoG
GtoA
TtoG
AtoT
AtoT
AtoT
TtoC
AtoC
TtoC
TtoA
AtoC
AtoG
TtoC
GtoA
AtoG
AtoG
AtoG
AtoC
TtoA
GtoT
AtoC
CtoT
AtoT
GtoA
TtoC
AtoG
TtoC
GtoA

minlevel
0.1034
0.1
0.1111
0.1212
0.1667
0.1
0.1
0.1
0.1
0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1042
0.1176
0.1429
0.1667
0.1111
0.1034
0.1
0.1
0.1
0.125
0.125
0.1786
0.1176
0.125
0.1
0.1
0.1
0.1176
0.1071
0.1
0.1
0.1538
0.1
0.1
0.1379
0.2787
0.125
0.102
0.1
0.1111
0.1
0.1
0.1034
0.1818
0.1053
0.1
0.125
0.2632
0.125
0.1
0.1071
0.1
0.1
0.1
0.1
0.15
0.1034
0.125
0.1
0.1
0.1053
0.4
0.1667
0.1053
0.1
0.6667
0.8636
0.1429
0.1009
0.1765
0.1176
0.1176
0.1176
0.1111
0.1
0.1
0.2727
0.1111
0.5263
0.1111
0.1
0.1
0.2727
0.125
0.1176

maxlevel
0.1212
0.1176
0.15
0.1579
0.1667
0.1111
0.2
0.1818
0.1
0.1818
0.1176
0.1
0.3636
0.1
0.1
0.1053
0.2143
0.75
0.1739
0.1875
0.1765
0.2727
0.2
0.1
0.1053
0.1333
0.5
0.5455
0.1818
0.1667
0.1053
0.1429
0.1
0.2
0.1429
0.1111
0.1538
0.1667
0.1
0.2
0.6897
0.8571
0.3529
0.2667
0.1
0.1304
0.125
0.2105
0.2564
0.2
0.3
0.2857
0.4545
0.4444
0.1923
0.1
0.2
0.1111
0.1818
0.1923
0.1
0.1818
0.1111
0.7143
0.1176
0.1
0.1667
0.5833
0.6
0.2963
0.1818
0.9565
1
0.2143
0.1094
0.4
0.1481
0.125
0.1765
0.1562
0.1
0.1
0.4615
0.1667
0.7222
0.1667
0.1818
0.5
0.75
0.2727
0.1379

no.of
informative
individuals
7
2
7
5
5
6
2
2
2
3
3
2
4
2
2
4
6
8
4
5
16
6
2
3
2
4
4
3
5
2
4
4
3
5
3
6
2
3
2
5
8
8
9
8
3
3
4
3
18
3
7
4
10
6
3
2
13
6
2
14
2
4
6
2
3
3
5
2
2
19
3
4
14
3
4
13
2
4
5
10
2
2
2
2
3
4
2
9
6
3
4

no.ofRDD
2
2
2
2
2
2
2
2
2
2
2
2
4
2
2
3
3
6
2
2
6
2
2
2
2
2
3
3
2
2
2
3
2
2
2
2
2
2
2
2
8
8
8
5
2
2
2
2
17
2
6
4
10
3
2
2
8
4
2
6
2
2
2
2
3
2
2
2
2
14
2
4
14
2
2
12
2
2
3
2
2
2
2
2
2
2
2
8
5
2
2

coverage
range
[29,34]
[10,17]
[10,22]
[19,33]
[12,18]
[10,19]
[10,10]
[10,11]
[10,10]
[11,13]
[10,17]
[10,10]
[10,17]
[10,10]
[10,10]
[10,19]
[14,48]
[12,51]
[21,23]
[12,33]
[16,25]
[11,31]
[10,10]
[10,10]
[10,19]
[15,16]
[10,24]
[11,28]
[17,22]
[12,16]
[10,19]
[10,15]
[10,10]
[10,17]
[14,28]
[10,18]
[10,13]
[12,13]
[10,10]
[10,10]
[13,90]
[16,105]
[17,89]
[15,104]
[10,10]
[18,23]
[10,16]
[10,19]
[23,220]
[10,11]
[10,38]
[10,14]
[11,20]
[18,25]
[16,26]
[10,10]
[10,37]
[10,20]
[10,11]
[20,44]
[10,10]
[20,22]
[27,29]
[14,17]
[10,17]
[10,10]
[18,20]
[11,12]
[10,12]
[11,31]
[10,11]
[11,23]
[10,38]
[14,14]
[66,110]
[15,51]
[17,28]
[16,18]
[17,20]
[18,33]
[10,10]
[10,10]
[12,13]
[10,12]
[18,19]
[10,12]
[10,11]
[10,25]
[11,21]
[11,16]
[17,29]

TableS10

chr15:48805813
chr12:97531790
chr17:53422008
chr17:53422007
chr3:151941692
chr19:63787013
chr17:43360315
chr2:122201354
chr19:56899506
chr2:175134050
chr2:175134052
chr2:33641492
chr2:33641569
chr16:4807611
chr16:4837266
chr16:4837265
chr16:4835123
chr5:148854163
chr5:148855469
chr17:73617397
chr10:75243755
chr12:54513584
chr15:81598476
chr19:11323733
chr5:32265517
chr12:63376543
chr17:6853865
chr3:195843153
chr3:195843909
chr17:5377951
chr7:130280164
chr7:130280166
chr17:3856523
chr17:3856959
chr8:144716364
chr8:144733380
chr8:61696667
chr8:61696761
chr8:61696958
chr2:74039548
chr7:149770570
chr7:149774909
chr7:149774910
chr7:115685336
chr7:115685340
chr7:115685341
chr7:115685837
chr2:233155899
chr2:224540123
chr2:64310188
chr2:64332175
chr2:64332474
chr8:26284299
chr7:129562544
chr17:25599580
chr17:25599950
chr17:4119467
chr17:4120227
chr17:4122316
chr17:27493841
chr18:19952164
chr3:14959512
chr17:40111151
chr17:40122478
chr5:3561952
chr5:3561954
chr3:52302157
chr3:42653839
chr3:42659887
chr3:42659888
chr3:42660398
chr3:42662477
chr3:42662881
chr3:42664984
chr16:88563788
chr4:25358215
chr4:25458292
chr7:99870895
chr7:99870896
chr19:44866563
chr19:44866566
chr19:44866610
chr4:6728095
chr2:87905683
chr2:87905718
chr2:87905719
chr2:87905737
chr2:87905784
chr4:142367449
chr3:45697205
chr2:217055919
chr16:80287688
chr16:80300943
chr4:185508424
chr18:17463188
chr18:17463193

AC012100.1
AC013283.1
AC015813.1
AC015813.1
AC016142.1
AC016629.3
AC018521.1
AC018737.4
AC018755.7
AC018890.2
AC018890.2
AC020594.2
AC020594.2
AC020663.1
AC020663.1
AC020663.1
AC020663.1
AC021078.3
AC021078.3
AC021593.2
AC022400.4
AC023055.2
AC024270.1
AC024575.3
AC025181.1
AC025262.1
AC027763.1
AC046143.1
AC046143.1
AC055839.1
AC058791.1
AC058791.1
AC067815.1
AC067815.1
AC067930.1
AC067930.1
AC068389.1
AC068389.1
AC068389.1
AC073046.3
AC073111.1
AC073111.1
AC073111.1
AC073130.3
AC073130.3
AC073130.3
AC073130.3
AC073254.1
AC073641.1
AC074289.1
AC074289.1
AC074289.1
AC079097.1
AC087071.2
AC087644.3
AC087644.3
AC087742.2
AC087742.2
AC087742.2
AC090616.1
AC090772.3
AC090937.1
AC091152.2
AC091152.2
AC091947.1
AC091947.1
AC092045.1
AC092047.3
AC092047.3
AC092047.3
AC092047.3
AC092047.3
AC092047.3
AC092047.3
AC092143.3
AC092436.2
AC092436.2
AC092849.1
AC092849.1
AC093063.1
AC093063.1
AC093063.1
AC093323.1
AC093616.2
AC093616.2
AC093616.2
AC093616.2
AC093616.2
AC096733.1
AC098476.2
AC098820.1
AC099524.1
AC099524.1
AC103540.1
AC106037.2
AC106037.2

coding_exon
mixed
coding_exon
coding_exon
mixed
UTR5
mixed
mixed
coding_exon
mixed
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
coding_exon
UTR3
mixed
mixed
mixed
coding_exon
mixed
mixed
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3

ENST00000414925:VtoL;
ENST00000414925:VtoE;

ENST00000417847:LtoP;

ENST00000321919:TtoA;ENST00000381983:TtoA;ENST00000436648:TtoA;ENST000
ENST00000321919:MtoT;ENST00000381983:MtoT;ENST00000436648:MtoT;ENST0
ENST00000321919:MtoI;ENST00000381983:MtoI;ENST00000436648:MtoI;ENST000

ENST00000379625:HtoR;

ENST00000399540:LtoP;ENST00000399541:LtoP;

ENST00000262467:RtoS;ENST00000269280:RtoS;ENST00000345221:RtoS;ENST000

ENST00000398832:RtoC;

42

+
+

+
+
+
+

+
+

+
+

+
+
+
+

+
+
+

+
+
+

+
+
+

+
+
+
+

+
+
+
+
+
+

+
+

+
+

AtoG
TtoC
GtoT
TtoA
AtoG
CtoT
AtoG
AtoT
TtoC
AtoT
TtoC
TtoA
AtoG
AtoG
TtoC
GtoT
TtoC
AtoG
AtoC
CtoG
AtoG
AtoG
TtoA
AtoG
TtoC
AtoT
TtoC
AtoT
TtoG
AtoT
AtoG
AtoG
TtoG
TtoG
AtoG
TtoA
CtoT
TtoC
AtoT
AtoG
AtoG
CtoG
TtoG
AtoG
TtoC
AtoT
TtoC
TtoC
TtoC
TtoC
TtoA
TtoC
CtoA
TtoC
AtoC
AtoG
TtoA
AtoG
TtoA
CtoT
TtoC
TtoC
GtoA
AtoG
CtoG
TtoG
TtoC
TtoC
AtoT
GtoC
CtoG
AtoG
CtoT
AtoT
TtoC
TtoC
GtoA
TtoC
AtoC
CtoG
AtoC
GtoA
CtoA
GtoA
CtoT
AtoG
CtoT
AtoG
AtoG
TtoC
AtoG
TtoC
GtoA
AtoC
TtoC
CtoA

0.1111
0.1
0.2
0.1667
0.1333
0.1
0.1
0.125
0.1
0.1
0.1304
0.1
0.1154
0.1053
0.15
0.125
0.1481
0.1818
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.125
0.1
0.1
0.3889
0.1
0.4
0.4167
0.381
0.1
0.1176
0.1
0.1
0.1
0.1
0.125
0.2727
0.1
0.1667
0.1
0.1562
0.1
0.1
0.1
0.1
0.125
0.1
0.1
0.1053
0.1053
0.1316
0.1304
0.1667
0.1
0.1071
0.3077
0.1071
0.1
0.1
0.1
0.175
0.381
0.1667
0.12
0.1034
0.1304
0.1
0.1053
0.1176
0.2222
0.1
0.1364
0.1
0.1
0.1
0.1154
0.1
0.1
0.1
1
0.9
0.9907
0.9984
0.9957
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1

0.1212
0.1
0.2222
0.2
0.2
0.1
0.1111
0.1667
0.1111
0.1333
0.1538
0.2941
0.5833
0.1111
0.1818
0.1429
0.1818
0.2105
0.1538
0.1
0.1429
0.1818
0.1538
0.2143
0.1
0.2143
0.1538
0.1
0.7
0.1
0.9286
0.7
0.625
0.1818
0.1667
0.1905
0.1818
0.1
0.1667
0.1333
0.4
0.2
0.25
0.1538
0.25
0.1053
0.2
0.1
0.125
0.125
0.1
0.1765
0.1111
0.1538
0.8333
0.1818
0.2308
0.1053
0.2353
0.3333
0.1724
0.1
0.1
0.1111
0.1818
0.4762
0.1818
0.1818
0.1538
0.1481
0.2857
0.3333
0.1176
0.3333
0.1818
0.2
0.1
0.1364
0.1
0.1818
0.125
0.3077
0.1
1
0.9375
1
1
1
0.1053
0.1765
0.1818
0.1053
0.1
0.1538
0.1111
0.3077

4
3
2
2
7
2
2
3
2
4
7
5
7
3
3
3
4
5
3
2
3
2
2
3
3
2
2
3
2
2
5
5
2
3
3
11
4
3
4
5
3
2
4
4
8
4
5
2
3
2
3
4
2
6
5
8
2
5
6
2
5
2
2
6
2
2
3
2
7
7
14
10
5
2
2
2
2
3
4
4
4
10
2
2
3
15
11
6
4
11
2
2
5
2
7
10

2
2
2
2
4
2
2
2
2
2
2
3
5
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
5
4
2
3
2
6
2
2
3
2
2
2
3
2
2
3
2
2
2
2
2
2
2
2
5
3
2
2
2
2
3
2
2
2
2
2
2
2
3
4
13
5
2
2
2
2
2
2
2
2
3
7
2
2
3
15
11
6
2
6
2
2
2
2
4
7

[18,33]
[10,11]
[10,20]
[10,18]
[16,30]
[10,10]
[10,18]
[12,17]
[10,18]
[10,15]
[13,23]
[10,17]
[12,26]
[18,38]
[11,20]
[24,28]
[11,27]
[11,20]
[10,13]
[10,10]
[10,14]
[10,11]
[10,13]
[10,14]
[10,10]
[14,16]
[10,13]
[10,10]
[18,20]
[10,10]
[11,18]
[10,21]
[21,24]
[10,20]
[12,17]
[44,133]
[10,11]
[10,10]
[10,13]
[15,16]
[10,11]
[10,10]
[11,13]
[10,13]
[12,32]
[10,20]
[10,10]
[10,10]
[10,16]
[16,16]
[11,20]
[10,17]
[18,19]
[13,19]
[17,43]
[12,23]
[13,13]
[10,19]
[17,29]
[12,13]
[14,29]
[10,10]
[10,10]
[10,18]
[11,81]
[21,22]
[11,12]
[11,25]
[14,30]
[14,28]
[10,28]
[13,38]
[17,17]
[10,12]
[10,11]
[15,22]
[10,10]
[10,23]
[10,11]
[11,26]
[10,25]
[11,26]
[10,10]
[13,19]
[11,16]
[125,756]
[1350,6860]
[71,482]
[10,19]
[20,80]
[11,19]
[10,19]
[10,20]
[20,26]
[10,47]
[10,21]

TableS10

chr18:17463195
chr15:75258551
chr4:77090957
chr4:77097535
chr4:76190508
chr5:162804038
chr5:162804481
chr3:162629704
chr3:162629705
chr5:1129254
chr3:187677294
chr3:187677343
chr3:187677501
chr1:203949187
chr1:203949201
chr1:203949319
chr1:203949343
chr1:203949414
chr1:203949445
chr1:203949497
chr1:203949498
chr17:76003629
chr8:71649147
chr8:71648714
chr17:77580261
chr17:77603536
chr17:77608628
chr17:77629508
chr5:138751156
chr3:48997813
chr5:176879452
chr5:68696702
chr3:38139231
chr17:32556803
chr12:110676068
chr11:133640027
chr11:133631698
chr1:76001009
chr10:124800620
chr17:7069280
chr17:7069305
chr3:196477495
chr3:196477584
chr1:1227231
chr1:1217738
chr1:224419150
chr16:66249447
chr14:22606709
chr14:22606941
chr14:22607009
chr14:22618623
chr17:37323678
chr17:37328659
chr17:37328747
chr17:37277166
chr9:32415977
chr4:8458606
chr4:8458615
chr4:8419327
chr16:87739215
chr2:223501852
chr10:114154526
chr10:114166655
chr10:114177155
chr16:20715219
chr20:24952179
chr3:180777190
chr3:180788554
chr3:180788813
chr19:43913012
chr10:104231754
chr2:65327269
chr2:65327306
chr2:65327332
chr2:65341935
chr2:114432187
chr2:114432289
chr2:114432291
chr3:53883381
chr3:53879133
chr14:74599948
chr19:40913114
chr19:40903023
chr19:40916339
chr20:42684981
chr15:56691422
chr15:56676394
chr2:9548681
chr5:156923971
chr2:207190895
chr8:39080569
chr1:152828520
chr1:152821193
chr1:152821194
chr1:152821196
chr1:152821482

AC106037.2
AC107883.1
AC110615.2
AC110615.2
AC110760.2
AC112205.1
AC112205.1
AC112491.2
AC112491.2
AC116351.1
AC117414.2
AC117414.2
AC117414.2
AC119673.2
AC119673.2
AC119673.2
AC119673.2
AC119673.2
AC119673.2
AC119673.2
AC119673.2
AC120024.1
AC120194.1
AC120194.1
AC129510.2
AC129510.2
AC129510.2
AC129510.2
AC135457.2
AC137630.3
AC145098.2
AC145132.3
ACAA1
ACACA
ACAD10
ACAD8
ACAD8
ACADM
ACADSB
ACADVL
ACADVL
ACAP2
ACAP2
ACAP3
ACAP3
ACBD3
ACD
ACIN1
ACIN1
ACIN1
ACIN1
ACLY
ACLY
ACLY
ACLY
ACO1
ACOX3
ACOX3
ACOX3
ACSF3
ACSL3
ACSL5
ACSL5
ACSL5
ACSM3
ACSS1
ACTL6A
ACTL6A
ACTL6A
ACTN4
ACTR1A
ACTR2
ACTR2
ACTR2
ACTR2
ACTR3
ACTR3
ACTR3
ACTR8
ACTR8
ACYP1
AD000671.1
AD000671.1
AD000671.1
ADA
ADAM10
ADAM10
ADAM17
ADAM19
ADAM23
ADAM9
ADAR
ADAR
ADAR
ADAR
ADAR

UTR3
coding_exon
coding_exon
coding_exon
UTR3
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
coding_exon
UTR5
mixed
mixed
mixed
mixed
coding_exon
mixed
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3

ENST00000312493:WtoR;

ENST00000400233:TtoA;

ENST00000313698:RtoI;ENST00000455480:RtoI;
ENST00000281182:MtoK;ENST00000374752:MtoK;

ENST00000353662:EtoG;ENST00000354700:EtoG;
ENST00000366812:StoP;

ENST00000309951:StoP;ENST00000379923:StoP;
ENST00000356406:LtoP;ENST00000413009:LtoP;
ENST00000356406:GtoE;ENST00000413009:GtoE;
ENST00000317447:RtoQ;ENST00000393145:EtoK;ENST00000406948:RtoQ;
ENST00000354273:VtoA;ENST00000354655:VtoA;ENST00000356116:VtoA;ENST00
ENST00000354273:TtoR;ENST00000354655:TtoR;ENST00000356116:TtoR;ENST000

ENST00000323482:TtoP;ENST00000432802:TtoP;

ENST00000369905:FtoL;ENST00000446605:FtoL;
ENST00000260641:Wto*;ENST00000377982:Wto*;
ENST00000260641:TtoA;ENST00000377982:TtoA;

ENST00000335754:LtoQ;ENST00000482349:LtoQ;
ENST00000238618:VtoA;ENST00000357971:VtoA;
ENST00000222270:LtoP;ENST00000396924:LtoP;ENST00000420124:LtoP;
ENST00000222270:KtoE;ENST00000341701:KtoE;ENST00000396924:KtoE;ENST000
ENST00000222270:FtoV;ENST00000396924:FtoV;ENST00000420124:FtoV;
ENST00000372874:VtoG;

ENST00000310823:StoR;
ENST00000257527:LtoP;ENST00000394020:LtoP;ENST00000430702:LtoP;ENST0000

ENST00000292205:EtoG;ENST00000368471:EtoG;ENST00000368474:EtoG;ENST000

43

+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+

+
+
+
+
+
+

+
+
+
+

+
+
+
+
+
+
+

+
+
+

+
+

GtoA
TtoC
TtoC
CtoT
TtoA
GtoA
AtoT
TtoG
GtoA
AtoT
AtoC
AtoG
TtoC
AtoG
AtoG
GtoA
AtoG
AtoT
AtoG
CtoT
AtoG
CtoA
TtoC
AtoG
GtoC
AtoG
TtoC
AtoG
AtoG
TtoC
CtoT
TtoC
AtoG
CtoT
GtoT
TtoA
CtoA
TtoA
TtoC
TtoC
AtoG
TtoA
GtoA
AtoG
TtoG
TtoC
GtoA
CtoG
CtoG
GtoT
TtoA
CtoG
GtoC
CtoT
AtoG
TtoC
TtoC
GtoA
TtoG
GtoA
AtoG
TtoC
CtoG
AtoG
TtoC
AtoC
AtoG
TtoC
AtoC
TtoA
TtoC
GtoA
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
TtoA
AtoG
TtoC
TtoC
AtoG
TtoG
TtoG
TtoC
AtoG
TtoG
TtoC
AtoG
CtoA
AtoG
TtoA
AtoG
TtoC
TtoC

0.1429
0.1
0.1333
0.1
0.1
0.1
0.1
1
0.8571
0.1
0.1053
0.1
0.1
0.1212
0.1333
0.1
0.1
0.1176
0.12
0.1154
0.1154
0.1
0.1429
0.1
0.1333
0.1333
0.125
0.1333
0.1818
0.1
0.1
0.1053
0.1154
0.1071
0.1
0.1
0.1
0.1
0.1
0.1129
0.1333
0.1
0.1
0.1429
0.2727
0.1
0.1333
0.1
0.1
0.1
0.125
0.1379
0.1159
0.1429
0.1
0.1
0.1
0.1
0.1
0.1538
0.1053
0.125
0.1
0.1
0.1
0.1
0.1
0.1071
0.1
0.1
0.1
0.1
0.1
0.1
0.1081
0.1154
0.1364
0.1
0.1111
0.1176
0.1818
0.1429
0.1538
0.1
0.1333
0.1167
0.1
0.1
0.1
0.1
0.1
0.1
0.1538
0.1176
0.1124
0.1

0.1667
0.1
0.25
0.1667
0.1875
0.1111
0.125
1
1
0.2
0.3
0.1
0.1
0.5625
0.5
0.4211
0.4211
0.3636
0.2593
0.283
0.2642
0.2
0.1429
0.1667
0.1429
0.1818
0.2
0.1538
0.4545
0.125
0.1
0.1176
0.1538
0.1667
0.1
0.1
0.1176
0.1053
0.1
0.1324
0.5
0.1538
0.1538
0.2
0.7273
0.1429
0.1667
0.1818
0.1333
0.2
0.56
0.4
0.1474
0.1667
0.1818
0.1
0.1667
0.1111
0.1
0.3158
0.125
0.125
0.1
0.1333
0.1
0.1
0.1
0.1163
0.1
0.1818
0.1
0.2143
0.2
0.1
0.1279
0.1389
0.1818
0.1364
0.1667
0.1538
0.2105
0.1667
0.1818
0.2143
0.1449
0.1429
0.2
0.1818
0.1053
0.1111
0.1
0.1667
0.2308
0.3
0.3571
0.1184

4
2
6
7
3
3
2
3
2
3
2
2
4
17
14
18
14
5
13
15
15
2
2
2
5
4
10
3
6
6
2
2
4
5
2
2
2
4
2
11
4
4
5
3
5
4
3
2
2
3
5
8
4
3
4
2
3
2
4
2
3
4
5
2
2
3
3
4
2
5
3
2
4
3
8
6
4
6
4
2
6
5
4
3
3
6
6
2
4
3
2
2
5
10
11
8

2
2
2
4
3
2
2
3
2
2
2
2
2
15
11
10
10
4
9
9
8
2
2
2
2
2
4
2
6
3
2
2
2
3
2
2
2
2
2
4
2
2
2
2
3
2
2
2
2
2
4
8
3
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
3
3
3
2
2
2
2
2
3
2
3
3
2
2
2
2
2
4
8
8
2

[12,14]
[10,10]
[12,16]
[10,23]
[10,16]
[20,27]
[10,33]
[10,16]
[13,14]
[10,10]
[10,19]
[10,10]
[10,10]
[15,58]
[12,53]
[26,96]
[12,61]
[11,23]
[13,63]
[26,100]
[26,102]
[10,10]
[14,14]
[10,12]
[14,15]
[11,15]
[11,26]
[13,15]
[11,13]
[10,16]
[10,10]
[17,57]
[13,26]
[14,28]
[10,10]
[10,10]
[10,17]
[11,19]
[10,10]
[43,207]
[10,15]
[10,14]
[10,13]
[10,14]
[11,15]
[14,20]
[15,18]
[10,12]
[10,15]
[10,10]
[11,32]
[21,45]
[43,95]
[12,14]
[10,12]
[10,10]
[10,12]
[10,18]
[10,10]
[13,19]
[17,20]
[16,24]
[10,30]
[10,15]
[10,10]
[10,10]
[10,10]
[28,43]
[10,10]
[10,11]
[10,10]
[10,14]
[10,10]
[10,10]
[38,91]
[25,37]
[12,22]
[16,22]
[18,19]
[13,17]
[11,21]
[12,14]
[12,13]
[10,14]
[15,138]
[14,60]
[10,16]
[10,11]
[10,19]
[10,18]
[10,10]
[10,12]
[11,15]
[10,23]
[11,92]
[77,123]

TableS10

chr1:152821575
chr21:45468859
chr7:140025491
chr8:145586753
chr7:45726932
chr2:24896573
chr16:48908477
chr4:2901430
chr4:2901586
chr10:111872030
chr10:111882057
chr9:19111163
chr9:19105859
chr12:1765794
chr12:1767644
chr20:48942124
chr20:48940971
chr20:48941177
chr18:75995931
chr18:75998586
chr10:64237015
chr15:70835026
chr15:70831744
chr15:70835705
chr3:120783813
chr3:120790478
chr1:36329956
chr1:36331905
chr1:36332031
chr11:66810602
chr22:39092511
chr22:39092517
chr1:242654293
chr1:242639394
chr15:86975892
chr15:86976515
chr19:3004163
chr10:116049995
chr4:88275887
chr4:88278944
chr5:132239473
chr5:132239872
chr5:132240042
chr5:132240104
chr16:88589724
chr18:12361660
chr4:178592608
chr7:150472033
chr2:27135600
chr2:27131526
chr2:228128004
chr7:99997858
chr7:100001448
chr5:76394753
chr1:100119813
chr6:32244190
chr9:138691697
chr21:44228288
chr21:44228979
chr21:44230482
chr8:6602599
chr8:41598580
chr2:178111139
chr2:178111717
chr2:178113838
chr1:972134
chr9:87383670
chr1:11732990
chr5:177589635
chr5:177570614
chr5:177570769
chr1:110363250
chr1:110366071
chr1:110367851
chr11:62042741
chr7:17346365
chr7:17350458
chr2:61267089
chr2:61267085
chr2:61266254
chr2:61266255
chr2:61258727
chr12:8646440
chr6:143703017
chr6:107116016
chr6:107115461
chr6:107113062
chr6:107123530
chr6:107123531
chr6:107124403
chr1:157302593
chr1:157313073
chr1:33251282
chr1:33251288
chr17:52553339
chr17:19801956

ADAR
ADARB1
ADCK2
ADCK5
ADCY1
ADCY3
ADCY7
ADD1
ADD1
ADD3
ADD3
ADFP
ADFP
ADIPOR2
ADIPOR2
ADNP
ADNP
ADNP
ADNP2
ADNP2
ADO
ADPGK
ADPGK
ADPGK
ADPRH
ADPRH
ADPRHL2
ADPRHL2
ADPRHL2
ADRBK1
ADSL
ADSL
ADSS
ADSS
AEN
AEN
AES
AFAP1L2
AFF1
AFF1
AFF4
AFF4
AFF4
AFF4
AFG3L1
AFG3L2
AGA
AGAP3
AGBL5
AGBL5
AGFG1
AGFG2
AGFG2
AGGF1
AGL
AGPAT1
AGPAT2
AGPAT3
AGPAT3
AGPAT3
AGPAT5
AGPAT6
AGPS
AGPS
AGPS
AGRN
AGTPBP1
AGTRAP
AGXT2L2
AGXT2L2
AGXT2L2
AHCYL1
AHCYL1
AHCYL1
AHNAK
AHR
AHR
AHSA2
AHSA2
AHSA2
AHSA2
AHSA2
AICDA
AIG1
AIM1
AIM1
AIM1
AIM1
AIM1
AIM1
AIM2
AIM2
AK2
AK2
AKAP1
AKAP10

UTR3
mixed
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
coding_exon
mixed
UTR3
coding_exon
coding_exon
UTR3
mixed
UTR3
coding_exon
coding_exon
UTR3
coding_exon
mixed
mixed
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
mixed
mixed
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR5
mixed
mixed
UTR3
coding_exon

ENST00000072869:VtoA;ENST00000476491:VtoA;
ENST00000308860:EtoG;

ENST00000277900:LtoP;ENST00000356080:LtoP;ENST00000360162:LtoP;
ENST00000276914:ItoV;ENST00000411567:ItoV;

ENST00000349014:LtoQ;ENST00000371602:LtoQ;ENST00000396029:LtoQ;ENST000

ENST00000311669:ItoT;ENST00000331065:ItoT;ENST00000443764:ItoT;ENST00000

ENST00000357003:QtoR;ENST00000465513:QtoR;ENST00000478399:QtoR;ENST00

ENST00000269143:AtoT;

ENST00000323064:RtoQ;ENST00000359582:RtoQ;ENST00000360131:RtoQ;
ENST00000323064:LtoP;ENST00000359582:LtoP;ENST00000360131:LtoP;

ENST00000312916:FtoI;

ENST00000371694:MtoI;ENST00000371696:MtoI;

ENST00000264167:NtoK;ENST00000409888:NtoK;

ENST00000308158:YtoD;

ENST00000359172:TtoP;ENST00000369799:TtoP;

ENST00000244934:GtoR;ENST00000378024:GtoR;

ENST00000357022:TtoR;ENST00000389584:TtoR;ENST00000394457:TtoR;ENST000
ENST00000357022:LtoV;ENST00000389584:LtoV;ENST00000394457:LtoV;ENST000
ENST00000357022:KtoN;ENST00000389584:KtoN;ENST00000394457:KtoN;ENST00
ENST00000357022:EtoQ;ENST00000389584:EtoQ;ENST00000394457:EtoQ;ENST00

ENST00000285105:VtoA;ENST00000369066:VtoA;
ENST00000285105:CtoW;ENST00000369066:CtoW;

ENST00000368130:TtoA;

44

+
+
+
+

+
+
+
+
+

+
+

+
+
+

+
+
+
+
+
+
+
+

+
+

+
+

+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+

+
+
+

+
+
+
+
+
+
+

+
+
+
+
+
+
+

TtoC
AtoG
TtoC
AtoG
TtoC
TtoC
TtoG
AtoG
AtoG
TtoC
TtoA
AtoG
CtoA
TtoA
AtoC
TtoA
TtoC
TtoG
TtoG
TtoC
TtoA
TtoC
TtoC
CtoT
AtoG
TtoC
TtoG
TtoG
TtoA
GtoA
TtoC
AtoG
AtoC
TtoC
CtoA
TtoC
TtoA
CtoG
AtoG
TtoG
TtoG
TtoC
AtoT
TtoG
GtoA
GtoA
CtoA
TtoG
GtoA
TtoC
AtoT
AtoC
CtoT
TtoA
AtoG
TtoG
GtoC
GtoA
TtoA
TtoG
TtoC
TtoG
TtoA
TtoA
TtoG
TtoC
TtoC
GtoT
TtoG
TtoC
TtoC
AtoC
CtoA
AtoG
GtoC
AtoG
TtoC
CtoG
TtoG
GtoT
GtoC
TtoG
AtoG
AtoG
TtoC
TtoG
TtoA
AtoT
CtoT
AtoT
AtoG
TtoC
TtoA
TtoC
TtoC
TtoA

0.1532
0.1136
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1034
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1111
0.1176
0.1
0.1
0.1
0.1154
0.1333
0.125
0.1
0.1
0.1538
0.1
0.1
0.1389
0.4118
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1071
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1333
0.1
0.1
0.1
0.1081
0.2222
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1538
0.1111
0.12
0.125
0.4
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.14
0.125
0.125
0.125
0.1111
0.1026
0.1
0.1
0.1538
0.1
0.1
0.1818

0.2113
0.375
0.2143
0.1
0.125
0.2727
0.1176
0.1212
0.4
0.1111
0.1
0.3636
0.1053
0.2
0.16
0.125
0.1111
0.1429
0.1
0.2
0.1053
0.1333
0.1429
0.4762
0.1304
0.1176
0.1
0.1053
0.1351
0.1667
0.2
0.2
0.2
0.2
0.1429
0.1
0.2258
0.5217
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1176
0.1111
0.1667
0.1176
0.1875
0.1
0.2308
0.1
0.1429
0.1429
0.1818
0.1053
0.1667
0.1
0.1364
0.3333
0.125
0.2
0.1
0.1
0.1667
0.1667
0.1
0.12
0.2
0.1667
0.1333
0.2
0.5217
0.1429
0.2222
0.2222
0.4118
0.2
0.2105
0.1
0.1667
0.1333
0.1429
0.1905
0.15
0.1951
0.15
0.1111
0.1
0.1
0.1579
0.1333
0.1538
0.2

8
4
4
2
3
3
4
3
5
3
2
3
2
5
2
4
2
3
2
4
3
3
2
11
4
6
3
2
8
2
11
5
4
8
3
2
4
2
3
5
3
5
2
3
3
2
2
2
3
2
4
3
4
2
2
6
3
6
3
2
8
2
3
3
3
2
3
3
2
2
7
6
5
5
2
5
8
7
11
9
11
3
7
5
2
4
2
2
2
2
2
3
10
4
2
2

7
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
10
2
2
2
2
3
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
3
2
2
2
2
3
2
2
3
2
2
2
2
2
2
2
2
2
2
5
3
2
2
3
2
3
8
7
6
2
6
2
2
2
2
2
2
2
2
2
2
2
2
2

[50,124]
[13,44]
[10,14]
[10,10]
[16,18]
[11,20]
[10,17]
[10,36]
[10,10]
[10,18]
[10,10]
[10,11]
[19,20]
[10,11]
[15,25]
[16,30]
[10,18]
[14,30]
[10,10]
[10,10]
[10,19]
[15,20]
[17,22]
[23,57]
[18,23]
[10,17]
[10,20]
[19,20]
[26,49]
[13,15]
[10,19]
[10,20]
[10,10]
[11,13]
[10,14]
[10,10]
[31,38]
[23,34]
[10,10]
[10,10]
[10,10]
[10,10]
[10,10]
[10,10]
[10,10]
[19,20]
[10,17]
[10,27]
[12,28]
[10,17]
[10,19]
[10,20]
[10,13]
[10,10]
[10,14]
[19,21]
[11,15]
[19,30]
[10,12]
[10,20]
[22,38]
[10,13]
[10,16]
[10,10]
[10,10]
[10,20]
[10,12]
[10,12]
[10,10]
[20,26]
[10,42]
[17,37]
[15,25]
[10,16]
[10,23]
[14,21]
[10,10]
[10,18]
[11,38]
[15,20]
[16,21]
[10,10]
[10,29]
[10,15]
[21,51]
[16,21]
[16,20]
[16,41]
[18,40]
[36,39]
[10,10]
[10,10]
[13,20]
[15,20]
[10,13]
[10,11]

TableS10

chr17:19801962
AKAP10
chr17:19749580
AKAP10
chr13:41791279
AKAP11
chr13:41773350
AKAP11
chr13:41780624
AKAP11
chr13:41789733
AKAP11
chr13:41785184
AKAP11
chr15:83929949
AKAP13
chr15:84061587
AKAP13
chr15:84008801
AKAP13
chr15:84008799
AKAP13
chr15:84029108
AKAP13
chr15:84091269
AKAP13
chr15:84091617
AKAP13
chr9:111971083
AKAP2
chr9:111971512
AKAP2
chr7:91508102
AKAP9
chr9:116145871
AKNA
chr9:116153095
AKNA
chr9:116138289
AKNA
chr1:45808304
AKR1A1
chr7:133786993
AKR1B1
chr1:19505140
AKR7A2
chr1:19506136
AKR7A2
chr1:19503359
AKR7A2
chr19:55073308
AKT1S1
chr19:45430088
AKT2
chr1:33247069
AL020995.2
chr1:33247070
AL020995.2
chr1:33247074
AL020995.2
chr1:33248138
AL020995.2
chr1:33248139
AL020995.2
chr1:33248466
AL020995.2
chr1:23960583
AL031295.1
chr1:23282721
AL031428.1
chr1:23284878
AL031428.1
chr20:256273
AL034548.1
chr20:256428
AL034548.1
chr20:39163316 AL035652.3
chr22:39902358 AL035658.2
chr14:53963696 AL049778.1
chr6:137560512 AL050337.1
chr11:32075413 AL078612.4
chr11:32076646 AL078612.4
chr11:32081587 AL078612.4
chr14:102469509 AL117209.1
chr20:32764495 AL118520.1
chr20:33542040 AL121586.5
chr20:33542041 AL121586.5
chr20:30286905 AL121897.2
chr20:18497935 AL121900.5
chr1:158915221 AL121985.1
chr10:64235418 AL133417.1
chr14:101884411 AL137229.4
chr1:148547408 AL138795.5
chr1:158782897 AL138930.2
chr14:27804555 AL139023.1
chr14:27804604 AL139023.1
chr14:27804662 AL139023.1
chr14:27804672 AL139023.1
chr14:27804687 AL139023.1
chr14:27804753 AL139023.1
chr14:27804768 AL139023.1
chr14:27804783 AL139023.1
chr14:27804810 AL139023.1
chr14:27804827 AL139023.1
chr10:22658507 AL157831.5
chr10:22659930 AL157831.5
chr13:20750240 AL158032.5
chr9:5068376
AL161450.19
chr1:151884755 AL162258.1
chr9:95345441
AL353629.3
chr10:44818789 AL353801.1
chr9:130344178 AL356481.4
chr6:354831
AL357054.1
chr6:356309
AL357054.1
chr6:430523
AL357054.1
chr6:509128
AL357054.1
chr6:574853
AL357054.1
chr6:28201381
AL358933.2
chr9:130533046 AL441992.3
chr1:43942783
AL451062.1
chr9:37077230
AL512604.2
chr9:37078475
AL512604.2
chr9:37078811
AL512604.2
chr9:37078813
AL512604.2
chr9:37078878
AL512604.2
chr9:37079031
AL512604.2
chr1:159395260 AL590714.2
chr1:224100804 AL591895.1
chr1:46913700
AL593856.3
chr1:46915308
AL593856.3
chr1:225685300 AL606462.3
chr1:225685344 AL606462.3
chr1:225685345 AL606462.3
chr1:202639506 AL606489.3

coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
UTR3
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
coding_exon
mixed
mixed
mixed
UTR3
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed

ENST00000025301:VtoE;
ENST00000025301:TtoK;
ENST00000025301:StoP;
ENST00000025301:QtoR;
ENST00000025301:NtoD;
ENST00000361243:VtoG;ENST00000394518:VtoG;
ENST00000361243:LtoQ;ENST00000394510:LtoQ;ENST00000394518:LtoQ;
ENST00000361243:FtoL;ENST00000394518:FtoL;
ENST00000361243:FtoI;ENST00000394518:FtoI;

ENST00000356239:EtoG;
ENST00000223791:VtoA;ENST00000307564:VtoA;ENST00000374075:VtoA;ENST00
ENST00000223791:HtoR;ENST00000307564:HtoR;ENST00000374075:HtoR;ENST00

ENST00000285930:YtoS;ENST00000458165:YtoS;
ENST00000235835:StoP;ENST00000424403:StoP;
ENST00000235835:KtoN;ENST00000424403:KtoN;
ENST00000235835:FtoV;ENST00000424403:FtoV;

ENST00000412130:QtoH;

45

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+

+
+
+

+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+

+
+
+
+
+
+

+
+
+
+
+
+

TtoC
AtoG
TtoA
CtoA
TtoC
AtoG
AtoG
TtoG
TtoA
CtoG
TtoA
AtoG
TtoC
AtoT
TtoC
AtoG
AtoG
TtoC
AtoG
AtoG
AtoG
AtoC
TtoC
AtoC
TtoG
TtoA
AtoG
CtoT
AtoT
AtoG
GtoC
GtoT
TtoC
GtoT
CtoT
TtoG
AtoT
TtoC
TtoC
GtoA
TtoG
AtoC
TtoG
AtoG
TtoC
GtoA
AtoG
CtoG
GtoT
TtoC
AtoG
TtoC
AtoC
TtoC
CtoT
TtoC
CtoT
CtoT
CtoT
GtoA
GtoC
GtoC
GtoA
GtoC
CtoT
CtoT
TtoA
AtoG
TtoA
TtoC
TtoC
TtoG
AtoG
AtoC
CtoA
CtoA
AtoG
AtoT
AtoC
GtoC
CtoT
AtoT
TtoC
GtoA
TtoG
AtoT
AtoG
CtoT
AtoT
AtoG
AtoG
CtoT
GtoA
CtoA
AtoT
AtoC

0.1
0.1333
0.1
0.1
0.1
0.1053
0.4286
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1091
0.1
0.1429
0.1034
0.1
0.1
0.1
0.1034
0.1
0.1
0.1064
0.1
0.125
0.3
0.1053
0.1034
0.1026
1
0.1
0.2
0.1
0.1
0.1
0.1136
0.1
0.1
0.1
0.1
0.1429
0.125
0.1
0.1
0.1905
0.1818
0.125
0.1136
0.1
0.1
0.1
0.1053
0.1429
1
1
1
0.2319
1
1
0.9
1
1
0.975
0.1
0.1
0.92
0.1
0.1
0.1
0.1
0.1176
0.4375
0.9965
0.1
0.1
0.1
0.4
0.1667
0.1
0.1
0.25
0.1429
0.1429
0.12
0.1
0.1818
0.1579
0.1176
0.1
0.9615
0.1
0.1
0.1333

0.1667
0.1429
0.1
0.1
0.1111
0.1389
0.6364
0.1818
0.1667
0.2143
0.2667
0.1818
0.1667
0.1765
0.2
0.2778
0.1333
0.1818
0.125
0.1176
0.125
0.1053
0.1875
0.1
0.1667
0.1346
0.1053
0.3077
0.6
0.28
0.1111
0.125
1
0.1667
0.2667
0.1
0.1111
0.1
0.125
0.1
0.1176
0.125
0.2667
0.3333
0.2941
0.1176
0.1
0.2
0.2
0.1667
0.1494
0.1429
0.1
0.1429
0.2
0.1667
1
1
1
1
1
1
1
1
1
1
0.1154
0.125
1
0.1
0.1818
0.125
0.1
0.3
0.5
1
0.1
0.1818
0.1
0.9
0.1818
0.1818
0.1739
0.5
0.2143
0.1538
0.2667
0.3077
0.2
0.2
0.1429
0.1538
1
0.1538
0.1458
0.2

2
3
2
3
4
5
3
2
3
6
9
8
7
2
13
7
2
5
3
2
5
2
2
3
3
2
7
4
5
8
9
10
2
2
2
3
4
3
2
2
3
6
3
5
3
2
3
2
2
6
5
3
3
3
2
3
8
14
6
3
5
12
12
13
18
11
3
2
12
2
2
3
4
3
3
20
2
5
2
8
2
2
6
3
5
5
3
3
4
3
7
10
17
3
6
2

2
2
2
2
2
2
3
2
2
2
3
3
3
2
7
3
2
2
2
2
2
2
2
2
2
2
3
3
5
3
2
4
2
2
2
2
2
2
2
2
2
2
3
3
2
2
2
2
2
2
2
2
2
2
2
2
8
14
6
3
5
12
12
13
18
11
2
2
12
2
2
2
2
2
2
20
2
2
2
8
2
2
3
3
2
2
2
2
2
2
3
4
17
3
2
2

[10,12]
[14,15]
[10,11]
[10,10]
[10,18]
[19,37]
[11,15]
[10,11]
[10,12]
[10,14]
[10,23]
[10,11]
[10,12]
[10,18]
[18,78]
[19,57]
[10,15]
[11,35]
[17,31]
[17,30]
[10,16]
[20,96]
[16,29]
[10,20]
[10,12]
[47,52]
[10,20]
[13,18]
[11,26]
[19,25]
[27,29]
[26,39]
[142,143]
[10,12]
[10,15]
[10,11]
[10,18]
[10,10]
[16,45]
[10,10]
[10,17]
[10,16]
[15,40]
[18,37]
[17,40]
[10,17]
[10,10]
[10,21]
[11,20]
[12,16]
[44,91]
[10,31]
[10,10]
[10,21]
[10,19]
[12,14]
[10,25]
[16,55]
[23,57]
[24,69]
[36,82]
[33,136]
[11,58]
[15,39]
[15,76]
[17,95]
[10,26]
[10,16]
[10,95]
[10,10]
[10,11]
[20,40]
[10,20]
[11,17]
[12,16]
[220,571]
[10,10]
[10,12]
[10,10]
[10,20]
[11,12]
[10,11]
[10,23]
[16,76]
[14,14]
[13,14]
[15,25]
[10,13]
[10,23]
[11,19]
[14,28]
[13,20]
[10,43]
[10,23]
[10,49]
[10,15]

TableS10

chr1:202639507
chr1:202640808
chr1:202641827
chr1:202645728
chr1:202646998
chr1:202660460
chr1:15926588
chr1:15933812
chr6:32736410
chr6:32737723
chr6:32737725
chr6:32737727
chr6:30335478
chr6:30336358
chr6:30336961
chr6:30336971
chr6:30336985
chr6:30337185
chr6:30337201
chr6:30337213
chr6:30337235
chr6:30337346
chr6:30337347
chr6:30337353
chr6:30337384
chr6:30337386
chr6:30780408
chr1:20942196
chr6:32921691
chr6:32630486
chr6:32630527
chr6:32630530
chr6:32630557
chr6:32630680
chr6:32630700
chr6:32630718
chr6:32630724
chr21:45172621
chr1:38038070
chr9:115192920
chr9:115189164
chr9:115189168
chr9:115189169
chr3:106754077
chr3:106777404
chr19:54659731
chr10:97361033
chr10:97355780
chr9:38387268
chr12:110714311
chr6:24636277
chr1:163931204
chr16:29989236
chr16:29989237
chr16:29989238
chr17:23924270
chr14:77210115
chr12:108010630
chr12:108010584
chr7:101885422
chr7:101884654
chr17:18053854
chr11:106880962
chr4:113571881
chr4:113581570
chr4:113572115
chr4:113572817
chr4:113566354
chr4:113581710
chr4:113571103
chr2:202199066
chr11:46520669
chr11:46396045
chr11:46396043
chr16:54954210
chr16:54953428
chr2:128336224
chr2:128337474
chr2:128337724
chr11:10473084
chr11:10475011
chr17:77451416
chr4:25005570
chr14:76342725
chr17:4020759
chr17:4031414
chr17:4014320
chr17:4014416
chr17:4015175
chr17:4015839
chr5:14763154
chr5:139888199
chr5:139832072
chr5:139857026
chr5:139899251
chr7:91853839

AL606489.3
AL606489.3
AL606489.3
AL606489.3
AL606489.3
AL606489.3
AL606758.1
AL606758.1
AL662789.4
AL662789.4
AL662789.4
AL662789.4
AL662795.1
AL662795.1
AL662795.1
AL662795.1
AL662795.1
AL662795.1
AL662795.1
AL662795.1
AL662795.1
AL662795.1
AL662795.1
AL662795.1
AL662795.1
AL662795.1
AL662797.2
AL663074.1
AL669918.1
AL713966.1
AL713966.1
AL713966.1
AL713966.1
AL713966.1
AL713966.1
AL713966.1
AL713966.1
AL844908.1
AL929472.1
ALAD
ALAD
ALAD
ALAD
ALCAM
ALCAM
ALDH16A1
ALDH18A1
ALDH18A1
ALDH1B1
ALDH2
ALDH5A1
ALDH9A1
ALDOA
ALDOA
ALDOA
ALDOC
ALKBH1
ALKBH2
ALKBH2
ALKBH4
ALKBH4
ALKBH5
ALKBH8
ALPK1
ALPK1
ALPK1
ALPK1
ALPK1
ALPK1
ALPK1
ALS2CR4
AMBRA1
AMBRA1
AMBRA1
AMFR
AMFR
AMMECR1L
AMMECR1L
AMMECR1L
AMPD3
AMPD3
ANAPC11
ANAPC4
ANGEL1
ANKFY1
ANKFY1
ANKFY1
ANKFY1
ANKFY1
ANKFY1
ANKH
ANKHD1
ANKHD1
ANKHD1
ANKHD1
ANKIB1

mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
mixed
coding_exon

ENST00000277315:YtoN;ENST00000374173:YtoN;ENST00000409155:YtoN;

ENST00000306107:LtoR;ENST00000389926:LtoR;ENST00000389927:LtoR;ENST000
ENST00000293350:TtoP;ENST00000455361:TtoP;
ENST00000371221:StoA;ENST00000371224:StoA;
ENST00000377698:VtoA;
ENST00000261733:GtoR;ENST00000416293:GtoR;
ENST00000348925:GtoE;ENST00000357578:GtoE;ENST00000491546:GtoE;
ENST00000354775:VtoG;

ENST00000343075:ItoV;ENST00000429722:ItoV;ENST00000435370:ItoV;
ENST00000343075:HtoR;ENST00000429722:HtoR;ENST00000435370:HtoR;ENST00

ENST00000177648:StoG;ENST00000458497:StoG;
ENST00000177648:QtoR;ENST00000458497:QtoR;
ENST00000177648:NtoD;ENST00000458497:NtoD;
ENST00000177648:NtoD;ENST00000458497:NtoD;
ENST00000177648:LtoP;ENST00000458497:LtoP;
ENST00000177648:CtoG;ENST00000458497:CtoG;
ENST00000396902:LtoI;ENST00000396905:LtoI;ENST00000409099:LtoI;ENST00000
ENST00000298834:StoP;ENST00000314823:StoP;ENST00000314845:StoP;ENST000
ENST00000298834:RtoQ;ENST00000314823:RtoQ;ENST00000314845:RtoQ;ENST00
ENST00000298834:PtoA;ENST00000314823:PtoA;ENST00000314845:PtoA;ENST000

ENST00000256183:StoR;ENST00000396553:StoR;ENST00000431080:StoR;ENST000
ENST00000256183:AtoT;ENST00000396553:AtoT;ENST00000431080:AtoT;ENST000
ENST00000315368:StoT;

46

+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+

+
+
+

+
+
+

+
+
+
+
+
+
+

+
+
+
+

+
+
+
+
+

AtoT
GtoT
AtoT
TtoC
CtoA
AtoG
AtoG
AtoG
TtoC
GtoT
TtoC
AtoT
GtoT
AtoG
TtoC
GtoA
GtoC
TtoC
TtoC
AtoG
GtoA
CtoA
GtoA
TtoC
GtoA
TtoC
TtoC
CtoT
TtoC
TtoC
GtoA
GtoT
AtoG
TtoG
GtoT
AtoG
CtoT
CtoA
AtoG
TtoA
TtoA
TtoC
GtoT
TtoG
TtoC
AtoC
TtoG
TtoC
TtoC
GtoA
GtoA
TtoG
AtoG
GtoA
TtoA
AtoG
TtoG
AtoG
AtoG
CtoG
GtoA
TtoC
GtoA
AtoG
AtoG
AtoG
AtoG
TtoC
TtoG
TtoC
CtoA
TtoC
GtoA
CtoG
TtoG
TtoG
TtoA
GtoT
AtoT
TtoG
GtoA
AtoG
TtoA
AtoG
GtoA
CtoG
AtoG
TtoA
TtoA
GtoA
TtoG
TtoA
TtoC
AtoG
AtoG
TtoC

0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.2308
0.1
0.1579
0.1
0.6364
0.3571
0.2632
0.1667
0.2
0.1
0.8269
0.1667
0.1429
0.1
0.1
0.1667
0.1333
0.1765
0.1
0.1
0.1
0.1111
0.2418
0.1017
0.1
0.96
0.1009
0.9811
1
0.1
0.1
0.125
0.1538
0.1538
0.1333
0.1
0.1
0.1
0.1053
0.1053
0.1212
0.1
0.1053
0.1
0.117
0.5165
0.5
0.1
0.1
0.1176
0.1
0.1
0.1
0.1091
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.12
0.1
0.1
0.1
0.125
0.1

0.1818
0.1
0.1
0.1
0.1
0.1
0.2
0.1667
0.5
0.25
0.1818
0.1818
0.9333
0.9245
0.9565
0.5
0.3636
0.9615
0.9838
0.9845
0.2424
0.4375
0.8667
0.9868
0.3333
0.2
0.1176
0.25
0.1071
0.125
0.867
0.1282
0.1739
0.9767
0.1453
1
1
0.1
0.2308
0.1818
0.1667
0.2
0.1818
0.125
0.1818
0.1
0.1154
0.1111
0.1667
0.1111
0.1111
0.1333
0.1189
0.8511
0.6667
0.15
0.1
0.125
0.1053
0.1
0.1
0.1429
0.1
0.25
0.125
0.1667
0.1053
0.1176
0.1667
0.1
0.1
0.15
0.1
0.1
0.1053
0.2308
0.1667
0.1667
0.1
0.1333
0.1
0.1429
0.1
0.2
0.1
0.1
0.1429
0.1
0.1
0.1
0.2
0.125
0.1053
0.1
0.2
0.125

2
2
2
2
2
2
2
12
2
4
4
2
4
4
4
5
2
8
9
10
3
7
9
12
5
3
2
7
9
2
2
6
2
2
4
4
2
2
2
4
5
4
3
4
2
2
2
7
5
2
3
2
7
14
3
6
2
2
7
3
2
10
2
3
2
2
2
3
5
2
2
2
2
2
5
9
2
2
2
2
2
2
2
2
3
2
3
2
2
2
3
10
5
4
2
3

2
2
2
2
2
2
2
3
2
3
2
2
4
4
4
5
2
8
9
10
2
5
8
12
4
2
2
2
2
2
2
2
2
2
2
4
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
14
3
4
2
2
2
2
2
3
2
2
2
2
2
2
3
2
2
2
2
2
2
6
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2

[11,13]
[10,10]
[10,10]
[10,10]
[11,11]
[10,10]
[10,10]
[17,27]
[13,14]
[12,20]
[11,19]
[10,12]
[10,29]
[14,83]
[19,91]
[10,16]
[10,11]
[10,72]
[71,495]
[41,589]
[14,33]
[10,50]
[10,187]
[13,116]
[10,30]
[11,17]
[10,17]
[10,12]
[28,40]
[10,24]
[183,189]
[41,59]
[11,23]
[25,43]
[234,545]
[53,358]
[81,88]
[10,10]
[10,14]
[11,16]
[12,13]
[10,13]
[11,15]
[10,16]
[10,11]
[10,10]
[26,40]
[18,19]
[12,34]
[10,18]
[18,19]
[10,15]
[101,150]
[47,194]
[11,17]
[10,28]
[10,10]
[16,17]
[10,19]
[10,10]
[10,10]
[56,126]
[10,10]
[10,16]
[10,16]
[10,12]
[10,19]
[10,17]
[10,13]
[10,10]
[10,10]
[10,20]
[10,10]
[10,10]
[10,19]
[10,20]
[12,22]
[12,20]
[10,10]
[10,15]
[10,10]
[10,14]
[10,10]
[10,10]
[10,10]
[10,10]
[10,14]
[10,10]
[10,10]
[10,10]
[10,25]
[11,24]
[10,19]
[10,10]
[10,17]
[10,16]

TableS10

chr7:91867416
chr12:131837446
chr12:131812951
chr5:72887166
chr13:110343528
chr13:110356382
chr13:110356381
chr13:110330460
chr13:110343611
chr13:110344637
chr13:110344640
chr13:110329705
chr16:87877303
chr16:87880093
chr16:87910986
chr18:9246257
chr18:9246062
chr18:9246208
chr12:108952891
chr12:108950703
chr12:108951756
chr12:108961214
chr12:108961256
chr4:74209613
chr4:74231850
chr4:74231855
chr4:74231971
chr4:74160436
chr4:74160549
chr10:27363927
chr10:27382276
chr19:37822170
chr19:37779912
chr19:37780528
chr3:15728653
chr3:15686465
chr17:46127831
chr17:46127837
chr17:46128070
chr2:197571326
chr2:197659675
chr12:54918821
chr12:54921508
chr6:35165575
chr16:4691135
chr9:100585840
chr2:219807313
chr3:43593203
chr12:44109524
chr12:44111448
chr12:44111584
chr11:409582
chr11:408813
chr11:408336
chr15:66863951
chr15:66866841
chr15:66866825
chr15:66867257
chr15:66866826
chr15:66859824
chr15:66858357
chr15:66858358
chr15:66859049
chr9:99800767
chr9:99800751
chr10:81905325
chr10:81905357
chr4:122808662
chr4:122808829
chr5:150460531
chr6:18321959
chr21:33558358
chr21:33558677
chr21:33558678
chr22:22355974
chr11:65026864
chr18:2792673
chr21:44404137
chr11:65869506
chr11:65116047
chr11:113776699
chr11:116233829
chr11:116249516
chr11:116249525
chr22:28053844
chr16:70330666
chr14:23101337
chr14:23101015
chr14:23101013
chr14:23103065
chr14:23106368
chr17:33005096
chr17:33006038
chr17:33011775
chr17:32949975
chr17:32952647

ANKIB1
ANKLE2
ANKLE2
ANKRA2
ANKRD10
ANKRD10
ANKRD10
ANKRD10
ANKRD10
ANKRD10
ANKRD10
ANKRD10
ANKRD11
ANKRD11
ANKRD11
ANKRD12
ANKRD12
ANKRD12
ANKRD13A
ANKRD13A
ANKRD13A
ANKRD13A
ANKRD13A
ANKRD17
ANKRD17
ANKRD17
ANKRD17
ANKRD17
ANKRD17
ANKRD26
ANKRD26
ANKRD27
ANKRD27
ANKRD27
ANKRD28
ANKRD28
ANKRD40
ANKRD40
ANKRD40
ANKRD44
ANKRD44
ANKRD52
ANKRD52
ANKS1A
ANKS3
ANKS6
ANKZF1
ANO10
ANO6
ANO6
ANO6
ANO9
ANO9
ANO9
ANP32A
ANP32A
ANP32A
ANP32A
ANP32A
ANP32A
ANP32A
ANP32A
ANP32A
ANP32B
ANP32B
ANXA11
ANXA11
ANXA5
ANXA5
ANXA6
AOF1
AP000295.1
AP000295.1
AP000295.1
AP000347.4
AP000769.2
AP001011.3
AP001055.1
AP001107.1
AP001362.1
AP002373.1
AP006216.1
AP006216.1
AP006216.1
AP1B1
AP1G1
AP1G2
AP1G2
AP1G2
AP1G2
AP1G2
AP1GBP1
AP1GBP1
AP1GBP1
AP1GBP1
AP1GBP1

UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
mixed
mixed
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
mixed
mixed
coding_exon
UTR3
mixed
UTR3
mixed
coding_exon
coding_exon
mixed
mixed
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
coding_exon
coding_exon
coding_exon
UTR3
UTR3

ENST00000337516:StoP;ENST00000357997:StoP;
ENST00000296785:EtoG;
ENST00000267339:LtoP;
ENST00000267339:DtoN;ENST00000310847:EtoK;ENST00000375758:DtoN;
ENST00000267339:DtoG;ENST00000310847:EtoG;ENST00000375758:DtoG;
ENST00000267339:DtoG;
ENST00000267339:DtoE;ENST00000310847:PtoA;

ENST00000301030:KtoE;

ENST00000262126:LtoV;ENST00000383440:LtoV;
ENST00000262126:KtoE;ENST00000383440:KtoE;
ENST00000262126:EtoD;ENST00000383440:EtoD;
ENST00000261739:CtoW;ENST00000334689:VtoG;

ENST00000330838:TtoP;ENST00000358602:TtoP;ENST00000411811:TtoP;
ENST00000330838:LtoF;ENST00000358602:LtoF;ENST00000411811:LtoF;ENST0000
ENST00000330838:HtoD;ENST00000358602:HtoD;ENST00000411811:HtoD;ENST00
ENST00000330838:AtoV;ENST00000358602:AtoV;ENST00000411811:AtoV;ENST00

ENST00000306065:YtoN;

ENST00000383776:StoL;ENST00000383777:StoL;ENST00000399451:StoL;ENST0000

ENST00000328737:LtoV;ENST00000450567:LtoV;
ENST00000328737:DtoE;ENST00000409153:DtoE;ENST00000450567:DtoE;

ENST00000304283:DtoV;ENST00000446014:DtoV;ENST00000450067:DtoV;

ENST00000292246:FtoI;ENST00000396091:FtoI;ENST00000396092:FtoI;ENST00000

ENST00000332826:DtoG;ENST00000412024:DtoG;

ENST00000358235:NtoS;ENST00000465139:NtoS;
ENST00000358235:NtoD;ENST00000465139:NtoD;
ENST00000358235:LtoP;ENST00000465139:LtoP;
ENST00000358235:LtoP;ENST00000465139:LtoP;
ENST00000358235:LtoI;ENST00000465139:LtoI;
ENST00000358235:EtoK;ENST00000465139:EtoK;

ENST00000339399:TtoP;
ENST00000339399:KtoN;

ENST00000297792:LtoI;ENST00000388869:LtoI;ENST00000388870:LtoI;ENST00000

ENST00000413499:MtoL;

ENST00000375490:QtoH;
ENST00000292055:LtoI;ENST00000375288:LtoI;ENST00000375300:LtoI;ENST00000

ENST00000308724:NtoS;ENST00000397120:NtoS;
ENST00000308724:MtoL;ENST00000397120:MtoL;
ENST00000308724:MtoI;ENST00000397120:MtoI;

ENST00000339208:RtoT;ENST00000345615:RtoT;ENST00000346661:RtoT;ENST000
ENST00000339208:LtoI;ENST00000345615:LtoI;ENST00000346661:LtoI;ENST00000

47

+
+
+
+
+
+
+
+

+
+
+

+
+

AtoC
TtoC
TtoA
AtoG
TtoC
GtoA
AtoG
AtoG
CtoG
AtoT
CtoT
TtoC
AtoG
GtoT
AtoC
TtoG
AtoG
AtoT
TtoG
CtoA
TtoC
TtoA
GtoT
AtoC
GtoT
CtoG
CtoT
AtoG
TtoG
CtoT
GtoA
TtoA
AtoT
TtoC
CtoT
CtoA
AtoG
AtoG
GtoC
TtoG
TtoA
TtoC
TtoG
AtoG
AtoT
TtoC
AtoG
TtoA
AtoT
TtoC
GtoA
AtoG
AtoG
GtoT
AtoG
AtoG
TtoC
TtoC
CtoA
GtoA
AtoG
AtoG
AtoC
AtoC
AtoT
AtoG
TtoA
TtoC
AtoG
TtoC
CtoA
TtoC
TtoC
AtoT
TtoC
AtoT
TtoC
GtoA
AtoG
TtoC
GtoT
CtoA
TtoG
TtoG
TtoA
AtoC
AtoG
AtoC
GtoC
AtoG
TtoC
GtoC
CtoA
TtoC
AtoG
CtoT

0.1
0.1053
0.125
0.1
0.125
0.1429
0.1111
0.1
0.1154
0.1818
0.1176
0.1
0.1
0.125
0.1
0.1
0.1034
0.1
0.1
0.1
0.1053
0.1053
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1111
0.1
0.1
0.6
0.125
0.1
0.1
0.1
0.1
0.1667
0.1
0.1
0.1
0.1351
0.2
0.1111
0.1
0.125
0.1
0.125
0.1053
0.1
0.1071
0.1053
0.1042
0.1081
0.1
0.1429
0.1
0.1364
0.1
0.1
0.1
0.2
0.1
0.1
0.1
0.1042
0.1
0.1
0.1
0.1
0.1429
0.1
0.1034
0.1053
0.1026
0.1
0.1
0.1
0.1
0.1111
0.1
0.1

0.1111
0.1333
0.1333
0.1
0.1351
0.1765
0.2778
0.1111
0.1739
0.6364
0.4375
0.1333
0.1429
0.2308
0.2162
0.1429
0.1429
0.1429
0.1
0.1176
0.125
0.2
0.1429
0.1111
0.1
0.1053
0.1
0.1818
0.1176
0.1429
0.1
0.1
0.6154
0.1
0.1
0.1
0.1
0.1667
0.15
0.12
0.1
0.1304
0.1818
0.1
0.1
0.9167
0.2308
0.1818
0.1
0.1538
0.2
0.2
0.1087
0.1
0.1
0.4375
0.4118
0.1818
0.1333
0.1429
0.2
0.3
0.2143
0.1176
0.1111
0.1667
0.125
0.1429
0.1667
0.1429
0.1
0.1818
0.1818
0.1429
0.1
0.6667
0.1111
0.125
0.1
0.1667
0.1
0.25
0.1667
0.1
0.2857
0.125
0.25
0.1333
0.2
0.1
0.1538
0.1429
0.1
0.1667
0.1875
0.1

3
5
7
3
4
7
12
5
15
4
9
2
5
9
13
3
6
2
2
3
4
3
5
2
3
2
3
8
3
2
2
3
2
2
2
2
2
6
4
3
2
3
4
2
2
2
7
3
3
4
3
5
6
2
2
14
9
4
7
4
2
8
8
7
3
7
7
6
6
4
2
5
7
6
4
4
4
3
3
7
2
7
2
3
10
6
8
5
6
2
3
2
2
4
7
2

2
3
2
2
2
3
10
2
8
4
7
2
2
6
10
2
3
2
2
2
2
3
2
2
2
2
2
5
2
2
2
2
2
2
2
2
2
2
3
2
2
2
3
2
2
2
2
2
2
2
3
2
2
2
2
11
9
2
2
2
2
4
5
2
2
3
2
2
3
2
2
2
2
3
2
4
2
3
2
4
2
3
2
2
7
3
3
4
3
2
2
2
2
2
5
2

[10,18]
[15,19]
[15,24]
[10,20]
[16,37]
[14,20]
[14,26]
[10,18]
[12,37]
[10,15]
[14,29]
[10,15]
[10,14]
[20,33]
[10,37]
[14,20]
[14,30]
[10,14]
[10,10]
[10,17]
[16,19]
[15,28]
[10,14]
[10,27]
[10,10]
[10,19]
[10,10]
[10,22]
[10,17]
[10,14]
[10,10]
[10,10]
[13,19]
[10,10]
[10,10]
[10,10]
[10,10]
[10,12]
[18,20]
[10,25]
[10,10]
[10,23]
[10,24]
[10,10]
[10,10]
[10,12]
[13,16]
[10,11]
[10,10]
[10,13]
[10,12]
[10,12]
[10,46]
[10,10]
[10,10]
[14,47]
[10,18]
[12,20]
[10,15]
[15,16]
[10,15]
[10,24]
[20,48]
[11,18]
[18,28]
[12,19]
[26,48]
[14,38]
[12,20]
[14,14]
[10,10]
[11,22]
[10,11]
[10,19]
[10,10]
[11,18]
[10,19]
[10,17]
[10,10]
[24,48]
[10,10]
[10,16]
[11,12]
[10,10]
[11,25]
[16,20]
[16,29]
[15,38]
[20,39]
[10,10]
[10,27]
[10,14]
[10,10]
[13,18]
[10,16]
[10,10]

TableS10

chr7:100590958
chr11:976858
chr17:31075394
chr17:31075458
chr19:52033264
chr19:52033268
chr5:77509003
chr5:77460856
chr5:77441922
chr10:75551850
chr10:75553142
chr8:42145987
chr8:42146835
chr8:42146892
chr1:114248856
chr1:114240599
chr12:97651342
chr10:26829986
chr4:40590110
chr5:139920168
chr5:112204309
chr3:49695922
chr14:19993231
chr11:43299573
chr11:34860810
chr22:37743743
chr22:37743768
chr22:37743900
chr22:37744310
chr22:37813543
chr22:37813668
chr22:34867591
chr22:34867577
chr22:34385394
chr17:55878791
chr17:55879596
chr9:32963135
chr15:32973226
chr15:32950296
chr11:72073817
chr11:117976958
chr11:117978671
chr11:117978720
chr12:47616257
chr3:57532350
chr20:61380728
chr20:61386184
chr20:61389587
chr22:41543167
chr22:41560237
chr22:41523024
chr22:41523452
chr8:68275285
chr20:47082997
chr20:47075362
chr20:47083439
chr14:67187468
chr14:67187662
chr13:106009646
chr13:106008186
chr13:106009155
chr15:30704682
chr15:30695027
chr16:24849983
chr16:24860839
chr16:24838316
chr6:129970760
chr10:98972366
chr10:98972972
chr10:98973151
chr5:142573789
chr17:77418892
chr12:14986217
chr12:14986220
chr12:14986230
chr12:14986231
chr19:47084679
chr19:47103405
chr11:119851422
chr11:119856162
chr19:7440859
chr19:7427264
chr1:154201546
chr1:154188626
chr1:154184115
chr3:56738394
chr3:56738480
chr3:56736616
chr13:110753996
chr1:26971890
chr1:26978259
chr1:26980160
chr1:26980537
chr1:26980925
chr12:44531788
chr19:923198

AP1S1
AP2A2
AP2B1
AP2B1
AP2S1
AP2S1
AP3B1
AP3B1
AP3B1
AP3M1
AP3M1
AP3M2
AP3M2
AP3M2
AP4B1
AP4B1
APAF1
APBB1IP
APBB2
APBB3
APC
APEH
APEX1
API5L1
APIP
APOBEC3D
APOBEC3D
APOBEC3D
APOBEC3D
APOBEC3G
APOBEC3G
APOL3
APOL3
APOL6
APPBP2
APPBP2
APTX
AQR
AQR
ARAP1
ARCN1
ARCN1
ARCN1
ARF3
ARF4
ARFGAP1
ARFGAP1
ARFGAP1
ARFGAP3
ARFGAP3
ARFGAP3
ARFGAP3
ARFGEF1
ARFGEF2
ARFGEF2
ARFGEF2
ARG2
ARG2
ARGLU1
ARGLU1
ARGLU1
ARHGAP11A
ARHGAP11A
ARHGAP17
ARHGAP17
ARHGAP17
ARHGAP18
ARHGAP19
ARHGAP19
ARHGAP19
ARHGAP26
ARHGDIA
ARHGDIB
ARHGDIB
ARHGDIB
ARHGDIB
ARHGEF1
ARHGEF1
ARHGEF12
ARHGEF12
ARHGEF18
ARHGEF18
ARHGEF2
ARHGEF2
ARHGEF2
ARHGEF3
ARHGEF3
ARHGEF3
ARHGEF7
ARID1A
ARID1A
ARID1A
ARID1A
ARID1A
ARID2
ARID3A

UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
mixed
coding_exon
UTR3
UTR5
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
coding_exon
UTR5
mixed
mixed
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3

ENST00000329626:YtoD;ENST00000332231:YtoD;ENST00000448903:YtoD;ENST000

ENST00000255194:VtoG;
ENST00000255194:LtoP;

ENST00000256658:YtoH;ENST00000369566:YtoH;ENST00000369567:YtoH;ENST000

ENST00000295974:VtoF;
ENST00000257430:StoA;ENST00000395617:StoA;ENST00000457016:StoA;

ENST00000378852:LtoQ;ENST00000420461:LtoQ;ENST00000455725:LtoQ;

ENST00000337769:RtoH;ENST00000349314:RtoH;ENST00000397293:RtoH;ENST00
ENST00000337769:NtoD;ENST00000349314:NtoD;ENST00000397293:NtoD;ENST00

ENST00000156471:VtoG;
ENST00000156471:DtoE;

ENST00000353546:NtoS;ENST00000370275:NtoS;ENST00000370283:NtoS;

ENST00000263245:EtoG;ENST00000429508:EtoG;ENST00000437119:EtoG;

ENST00000262215:LtoQ;
ENST00000371917:YtoD;
ENST00000371917:StoP;

ENST00000361627:LtoV;

ENST00000275189:EtoG;ENST00000368149:EtoG;

ENST00000274498:CtoR;ENST00000378004:CtoR;

ENST00000319670:NtoT;ENST00000359920:NtoT;ENST00000398026:NtoT;
ENST00000319670:DtoG;ENST00000359920:DtoG;ENST00000398026:DtoG;
ENST00000361247:AtoE;ENST00000368315:AtoE;ENST00000435736:AtoE;
ENST00000313667:VtoA;ENST00000313695:VtoA;ENST00000361247:VtoA;ENST00
ENST00000296315:MtoV;ENST00000338458:MtoV;ENST00000413728:MtoV;ENST0
ENST00000296315:EtoG;ENST00000338458:EtoG;ENST00000413728:EtoG;ENST000

ENST00000324856:StoR;ENST00000374152:StoR;ENST00000457599:StoR;

48

+
+
+
+

+
+
+

+
+

+
+
+
+

+
+
+
+
+
+

+
+
+

+
+
+

+
+
+
+
+

+
+

+
+
+
+
+
+

+
+
+
+
+
+
+
+

CtoT
TtoG
TtoC
CtoA
CtoA
CtoA
TtoG
TtoC
TtoC
TtoC
CtoA
TtoC
TtoC
TtoC
TtoC
AtoG
GtoT
AtoC
GtoT
CtoA
TtoG
TtoA
TtoG
TtoA
AtoG
AtoG
TtoC
AtoC
AtoG
AtoG
TtoA
GtoA
AtoG
GtoA
GtoT
TtoA
TtoC
TtoG
CtoG
CtoG
TtoC
TtoC
TtoG
CtoA
TtoC
AtoG
TtoA
GtoA
AtoG
TtoC
AtoG
TtoA
TtoA
TtoG
TtoC
AtoT
TtoG
AtoT
TtoC
AtoG
TtoA
CtoG
GtoA
AtoC
TtoG
CtoT
AtoG
AtoT
TtoC
AtoC
TtoC
TtoA
GtoA
TtoG
GtoA
TtoA
AtoC
AtoG
AtoG
AtoG
AtoC
AtoG
CtoA
TtoC
AtoG
AtoG
AtoG
GtoA
TtoC
CtoG
TtoC
GtoA
GtoA
TtoA
AtoG
TtoA

0.1111
0.1
0.1
0.1
0.1429
0.12
0.125
0.1
0.1
0.1
0.1
0.1111
0.1
0.1053
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.12
0.1
0.1064
0.1429
0.2
0.1176
0.1
0.1364
0.1
0.1818
0.1
0.1
0.1
0.1
0.1
0.1176
0.1429
0.1
0.1
0.1176
0.1143
0.1
0.1
0.1579
0.1111
0.1
0.1
0.125
0.1154
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1111
0.1
0.1071
0.1
0.1111
0.1042
0.1053
0.1
0.1
0.1111
0.1
0.1
0.25
0.1
0.1148
0.102
0.1053
0.1081
0.1
0.1
0.1667
0.125
0.1
0.1
0.1034
0.1429
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1111
0.1
0.1
0.125

0.3
0.1818
0.1111
0.1
0.1579
0.1875
0.1818
0.1053
0.2727
0.1579
0.1
0.1111
0.2
0.2105
0.1111
0.1
0.2
0.1607
0.1
0.1
0.1
0.2353
0.1
0.1538
0.1818
0.2222
0.1304
0.3158
0.2727
0.1429
0.1818
0.1
0.2
0.1333
0.1
0.1
0.1429
0.1538
0.1111
0.1176
0.2143
0.1818
0.1
0.2
0.1852
0.1333
0.1
0.1333
0.1579
0.1429
0.1667
0.1333
0.1364
0.1538
0.1
0.1
0.1
0.1429
0.1875
0.1667
0.1
0.3077
0.2857
0.1538
0.3
0.2222
0.1111
0.1
0.1333
0.1
0.1176
0.3333
0.2
0.2353
0.1613
0.3333
0.1463
0.125
0.1667
0.1667
0.25
0.1
0.1667
0.1429
0.3333
0.1111
0.1
0.1
0.1
0.3333
0.1333
0.1429
0.2143
0.2
0.1
0.1538

2
2
6
3
4
12
2
3
5
8
4
2
3
6
6
3
2
4
2
3
2
4
2
7
3
2
3
4
3
4
2
2
2
3
3
3
3
4
3
6
4
7
3
5
7
3
2
2
4
5
9
6
3
3
2
2
2
4
5
6
2
9
4
8
6
12
2
2
8
2
2
2
2
2
13
19
7
2
3
3
4
3
11
3
11
3
5
2
3
12
8
9
7
9
2
4

2
2
2
2
2
5
2
2
4
3
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
4
2
3
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
3
2
2
7
2
4
2
4
2
2
2
2
2
2
2
2
6
17
3
2
2
2
3
2
3
2
4
2
2
2
2
9
2
4
3
3
2
2

[10,36]
[10,11]
[18,22]
[10,10]
[15,19]
[17,30]
[11,16]
[19,20]
[10,20]
[10,22]
[10,10]
[18,27]
[10,10]
[19,19]
[10,18]
[10,10]
[10,20]
[45,56]
[10,10]
[10,10]
[10,10]
[18,25]
[10,10]
[13,51]
[11,14]
[10,10]
[17,23]
[20,56]
[22,22]
[10,14]
[11,12]
[10,10]
[10,15]
[10,15]
[10,10]
[10,10]
[14,17]
[13,14]
[10,18]
[10,19]
[14,18]
[11,35]
[10,10]
[10,10]
[19,27]
[10,15]
[10,10]
[10,15]
[16,19]
[14,27]
[12,32]
[16,18]
[10,22]
[10,18]
[10,10]
[10,10]
[10,10]
[10,22]
[16,18]
[18,18]
[10,10]
[10,28]
[10,14]
[13,46]
[10,49]
[18,28]
[10,10]
[10,10]
[15,27]
[10,10]
[10,17]
[15,21]
[10,10]
[17,64]
[14,53]
[19,191]
[35,74]
[10,16]
[10,12]
[12,12]
[16,24]
[10,10]
[20,54]
[15,29]
[12,21]
[10,10]
[10,10]
[10,10]
[10,11]
[10,32]
[15,30]
[10,21]
[13,18]
[10,12]
[10,10]
[13,24]

TableS10

chr14:57897423
chr1:233412689
chr1:233405275
chr1:233443951
chr1:233405234
chr15:70665406
chr3:48940233
chr12:100320831
chr16:55840014
chr16:55844933
chr10:104426489
chr12:122033401
chr3:69237880
chr16:31385630
chr16:31385939
chr19:19026082
chr19:19029508
chr17:70636367
chr17:70637040
chr3:139486039
chr3:139439014
chr3:139423501
chr3:139446912
chr3:139497809
chr3:51401781
chr1:149075523
chr1:149075461
chr7:98784468
chr7:98789469
chr7:98784478
chr7:98780037
chr2:218827290
chr12:109357131
chr12:109357132
chr9:126679503
chr15:50636710
chr17:4565085
chr9:139629514
chr19:17982006
chr22:49410875
chr22:49413209
chr1:229202821
chr1:229202823
chr8:17965017
chr2:239019865
chr2:239024055
chr3:57280894
chr2:53878200
chr12:46828269
chr12:46828701
chr12:46829191
chr12:46829361
chr10:73557857
chr22:28560482
chr6:101197188
chr6:101063518
chr19:14092256
chr1:153582882
chr8:38115783
chr8:38116351
chr7:65195375
chr7:65195377
chr2:190243625
chr2:190243646
chr22:25160141
chr1:195320137
chr1:195358268
chr9:132345640
chr9:132366234
chr9:132366253
chr9:132366326
chr20:30488363
chr20:30480891
chr20:30488815
chr20:30490412
chr20:30490637
chr10:89567551
chr12:49500083
chr2:175645873
chr2:175646325
chr1:160195348
chr1:160200268
chr1:160200272
chr12:52193229
chr12:52193817
chr12:14525246
chr12:14542277
chr5:115195166
chr2:233867861
chr11:72211616
chr11:64422752
chr11:64420533
chr1:63057272
chr3:11572622
chr2:219795120
chr2:219793854

ARID4A
ARID4B
ARID4B
ARID4B
ARID4B
ARIH1
ARIH2
ARL1
ARL2BP
ARL2BP
ARL3
ARL6IP4
ARL6IP5
ARMC5
ARMC5
ARMC6
ARMC6
ARMC7
ARMC7
ARMC8
ARMC8
ARMC8
ARMC8
ARMC8
ARMET
ARNT
ARNT
ARPC1B
ARPC1B
ARPC1B
ARPC1B
ARPC2
ARPC3
ARPC3
ARPC5L
ARPP19
ARRB2
ARRDC1
ARRDC2
ARSA
ARSA
ARV1
ARV1
ASAH1
ASB1
ASB1
ASB14
ASB3
ASB8
ASB8
ASB8
ASB8
ASCC1
ASCC2
ASCC3
ASCC3
ASF1B
ASH1L
ASH2L
ASH2L
ASL
ASL
ASNSD1
ASNSD1
ASPHD2
ASPM
ASPM
ASS1
ASS1
ASS1
ASS1
ASXL1
ASXL1
ASXL1
ASXL1
ASXL1
ATAD1
ATF1
ATF2
ATF2
ATF6
ATF6
ATF6
ATF7
ATF7
ATF7IP
ATF7IP
ATG12
ATG16L1
ATG16L2
ATG2A
ATG2A
ATG4C
ATG7
ATG9A
ATG9A

coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
mixed
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR5
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR5
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
mixed
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon

ENST00000348476:StoA;ENST00000355431:StoA;ENST00000395168:StoA;ENST000
ENST00000264183:RtoI;ENST00000349213:RtoI;ENST00000366603:RtoI;ENST0000
ENST00000264183:KtoQ;ENST00000349213:KtoQ;ENST00000366603:KtoQ;
ENST00000264183:KtoE;ENST00000366603:KtoE;ENST00000391856:KtoE;

ENST00000356401:LtoV;ENST00000444790:LtoV;ENST00000449376:LtoV;
ENST00000261636:VtoA;

ENST00000245543:GtoA;
ENST00000393058:QtoP;ENST00000461822:QtoP;ENST00000469044:QtoP;ENST00
ENST00000358441:VtoG;ENST00000393058:VtoG;ENST00000461822:VtoG;ENST00
ENST00000358441:NtoD;ENST00000393058:NtoD;ENST00000461822:NtoD;ENST00

ENST00000322733:VtoG;ENST00000342710:VtoG;ENST00000354396:VtoG;ENST00
ENST00000322733:StoC;ENST00000342710:StoC;ENST00000354396:StoC;ENST000
ENST00000432884:WtoC;
ENST00000432884:VtoL;
ENST00000432884:NtoD;
ENST00000432884:LtoF;

ENST00000249822:EtoG;
ENST00000269260:KtoQ;ENST00000346341:KtoQ;ENST00000381488:KtoQ;ENST00
ENST00000222250:VtoA;ENST00000379656:VtoA;
ENST00000216124:QtoP;ENST00000356098:QtoP;ENST00000395619:QtoP;ENST00

ENST00000262097:HtoN;ENST00000314146:HtoN;ENST00000381733:HtoN;ENST00
ENST00000264607:ItoV;ENST00000409297:ItoV;

ENST00000317126:NtoD;ENST00000317168:NtoD;ENST00000342444:NtoD;ENST00

ENST00000215906:DtoV;ENST00000382701:DtoV;ENST00000456021:DtoV;

ENST00000334909:ItoT;ENST00000352480:ItoT;ENST00000372393:ItoT;ENST00000

ENST00000306058:VtoA;ENST00000358956:VtoA;ENST00000375687:VtoA;ENST00

ENST00000261168:VtoA;

ENST00000377264:StoP;ENST00000421419:StoP;
ENST00000377262:NtoD;ENST00000377264:NtoD;ENST00000421419:NtoD;
ENST00000317868:WtoR;ENST00000371120:WtoR;
ENST00000361242:TtoP;ENST00000396761:TtoP;ENST00000409422:TtoP;ENST000

49

+
+

+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+

+
+
+

+
+

+
+

+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+

+
+
+

+
+

+
+

+
+

TtoG
GtoT
AtoC
AtoG
TtoC
AtoG
TtoG
TtoC
AtoG
TtoC
TtoA
TtoG
AtoG
AtoG
TtoC
CtoG
TtoC
GtoC
CtoA
AtoC
TtoG
AtoG
AtoG
TtoC
AtoG
TtoG
AtoT
GtoC
GtoC
AtoG
CtoT
AtoG
CtoG
GtoA
TtoA
AtoG
AtoC
TtoC
TtoC
AtoC
GtoC
TtoG
AtoG
CtoA
AtoG
AtoG
AtoG
AtoG
TtoA
AtoT
TtoG
CtoA
AtoG
AtoG
TtoC
AtoG
AtoG
AtoG
TtoA
TtoC
GtoA
GtoA
AtoG
CtoG
AtoT
AtoG
AtoG
TtoC
GtoC
GtoA
CtoT
TtoC
AtoT
AtoG
AtoG
TtoC
AtoG
TtoA
AtoG
TtoG
AtoC
TtoC
AtoG
AtoG
TtoG
TtoC
CtoA
TtoC
GtoT
GtoA
TtoC
AtoG
TtoC
CtoT
AtoC
TtoC

0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1053
0.2
0.1
0.1
0.1667
0.1111
0.1
0.1
1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.2
0.1
0.1
0.1154
0.1
0.1538
0.1765
0.1667
0.1
0.1053
0.1
0.12
0.1304
0.1
0.1
0.1304
1
0.125
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1
0.5
0.1
0.1
0.1
0.1429
0.1667
0.1
0.1
0.1
0.1053
0.1
0.1429
0.1667
0.1
0.4167
0.1
0.125
0.1579
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1176
0.1
0.1176
0.1
0.1304
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1

0.125
0.125
0.1429
0.1053
0.1053
0.1
0.15
0.1364
0.2857
0.1538
0.1667
0.2308
0.2
0.1
0.1
1
0.1053
0.1333
0.1
0.1
0.1818
0.1429
0.1
0.1667
0.25
0.1053
0.1176
0.3333
0.4444
0.3571
0.2
0.4615
0.1818
0.1538
0.1667
0.1429
0.1429
0.1364
0.1
0.1538
1
0.1333
0.2
0.1333
0.1
0.1
0.1
0.125
0.1333
0.1667
0.125
0.1053
0.1818
0.1429
0.1
0.1
0.6522
0.1364
0.1
0.2
0.2
0.5455
0.2
0.1429
0.1
0.1818
0.1176
0.3571
0.5333
0.6154
0.7273
0.1
0.1667
0.1818
0.1
0.1
0.1
0.1429
0.1
0.125
0.1053
0.1
0.15
0.125
0.1
0.125
0.1
0.1538
0.1429
0.1176
0.1
0.1
0.1429
0.1111
0.1667
0.125

2
2
2
2
5
2
6
7
2
3
5
8
9
3
2
15
3
6
2
2
2
3
2
2
3
4
2
3
4
5
3
8
10
9
7
3
5
2
2
3
3
6
3
3
3
2
2
6
3
2
3
3
4
5
5
2
3
3
2
2
4
6
4
3
2
3
3
4
4
2
2
2
7
6
2
2
2
2
3
5
2
2
3
3
2
2
3
2
2
2
2
2
6
3
3
3

2
2
2
2
2
2
2
3
2
2
3
3
2
2
2
15
2
4
2
2
2
2
2
2
2
2
2
2
3
2
3
8
5
2
3
2
2
2
2
2
3
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
3
3
2
2
2
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2

[10,16]
[16,19]
[10,14]
[10,19]
[10,19]
[10,10]
[10,20]
[19,37]
[10,14]
[10,13]
[10,14]
[13,23]
[10,18]
[10,10]
[10,10]
[10,64]
[19,30]
[10,15]
[10,10]
[10,10]
[10,11]
[10,14]
[10,10]
[10,12]
[10,12]
[10,19]
[10,17]
[18,26]
[10,18]
[13,14]
[10,17]
[10,17]
[19,33]
[38,39]
[10,19]
[21,26]
[14,23]
[10,22]
[10,10]
[13,23]
[11,12]
[16,17]
[14,15]
[10,15]
[10,10]
[10,10]
[10,10]
[10,16]
[10,15]
[10,12]
[10,16]
[10,19]
[11,17]
[10,14]
[10,10]
[10,10]
[23,51]
[10,22]
[10,10]
[10,10]
[10,14]
[11,13]
[10,10]
[10,14]
[10,10]
[11,19]
[10,18]
[14,14]
[12,15]
[10,13]
[11,12]
[21,21]
[12,24]
[11,19]
[10,10]
[10,10]
[10,10]
[10,14]
[10,10]
[10,16]
[10,19]
[10,10]
[19,20]
[16,17]
[10,10]
[16,17]
[10,10]
[13,23]
[10,14]
[10,17]
[10,10]
[10,20]
[10,14]
[10,18]
[10,12]
[16,20]

TableS10

chr11:284418
chr11:282983
chr2:215922689
chr2:215922691
chr2:38376731
chr2:38375800
chr2:38375890
chr11:63160279
chr11:107744907
chr16:79632524
chr12:6913617
chr12:6921558
chr5:151102585
chr5:151102588
chr13:112587555
chr3:184119240
chr19:19619449
chr19:19617490
chr3:195639482
chr3:195639481
chr3:195605188
chr1:167363146
chr12:109267075
chr12:109269372
chr12:109272801
chr12:109272888
chr17:3773921
chr17:3773923
chr12:88542149
chr12:88537970
chr12:88538023
chr12:88542103
chr12:88508919
chr3:132217680
chr3:132203407
chr18:41918111
chr19:1195818
chr20:57038877
chr20:57040692
chr20:57038875
chr20:57038756
chr20:57038876
chr20:57037228
chr20:57037238
chr20:57037240
chr20:57037290
chr17:44328138
chr17:44328146
chr12:52345243
chr2:175751142
chr2:175751143
chr2:175751145
chr2:175757196
chr17:70546578
chr4:656234
chr21:26018729
chr7:98894811
chr7:98893754
chr7:98901713
chr21:34197634
chr19:46629493
chr17:37900711
chr12:122805037
chr12:122795451
chr5:172394475
chr7:149207791
chr3:115012358
chr3:115012510
chr3:115013285
chr14:66875010
chr22:16455263
chr7:128292697
chr7:128290349
chr7:128290341
chr9:116399939
chr6:31624154
chr8:54847116
chr8:54916703
chr4:42161697
chr4:42107853
chr4:42108951
chr1:152585750
chr1:152585378
chr1:152588928
chr1:46873333
chr1:46873336
chr1:46873696
chr17:17865253
chr1:28435956
chr1:28437197
chr3:48475813
chr6:16411005
chr22:44618515
chr22:44618522
chr16:70446498
chr16:70446633

ATHL1
ATHL1
ATIC
ATIC
ATL2
ATL2
ATL2
ATL3
ATM
ATMIN
ATN1
ATN1
ATOX1
ATOX1
ATP11A
ATP11B
ATP13A1
ATP13A1
ATP13A3
ATP13A3
ATP13A3
ATP1B1
ATP2A2
ATP2A2
ATP2A2
ATP2A2
ATP2A3
ATP2A3
ATP2B1
ATP2B1
ATP2B1
ATP2B1
ATP2B1
ATP2C1
ATP2C1
ATP5A1
ATP5D
ATP5E
ATP5E
ATP5E
ATP5E
ATP5E
ATP5E
ATP5E
ATP5E
ATP5E
ATP5G1
ATP5G1
ATP5G2
ATP5G3
ATP5G3
ATP5G3
ATP5G3
ATP5H
ATP5I
ATP5J
ATP5J2
ATP5J2
ATP5J2
ATP5O
ATP5SL
ATP6V0A1
ATP6V0A2
ATP6V0A2
ATP6V0E1
ATP6V0E2
ATP6V1A
ATP6V1A
ATP6V1A
ATP6V1D
ATP6V1E1
ATP6V1F
ATP6V1F
ATP6V1F
ATP6V1G1
ATP6V1G2
ATP6V1H
ATP6V1H
ATP8A1
ATP8A1
ATP8A1
ATP8B2
ATP8B2
ATP8B2
ATPAF1
ATPAF1
ATPAF1
ATPAF2
ATPIF1
ATPIF1
ATRIP
ATXN1
ATXN10
ATXN10
ATXN1L
ATXN1L

coding_exon
coding_exon
UTR3
UTR3
mixed
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
mixed
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
mixed
coding_exon
UTR3
UTR5
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
mixed
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
UTR3
coding_exon
UTR3
mixed
mixed
mixed
mixed

ENST00000312105:WtoR;ENST00000409479:WtoR;ENST00000409548:WtoR;ENST0
ENST00000312105:KtoR;ENST00000382625:KtoR;ENST00000409479:KtoR;ENST000

ENST00000291503:StoP;ENST00000357324:StoP;
ENST00000291503:NtoT;ENST00000357324:NtoT;
ENST00000256031:AtoT;ENST00000310773:AtoT;ENST00000439040:AtoT;
ENST00000256031:AtoD;ENST00000310773:AtoD;ENST00000439040:AtoD;
ENST00000367813:VtoA;ENST00000367815:VtoA;ENST00000367816:VtoA;
ENST00000308664:CtoW;ENST00000313432:CtoW;ENST00000395494:CtoW;

ENST00000261173:VtoA;ENST00000348959:VtoA;ENST00000359142:VtoA;ENST00
ENST00000261173:LtoR;ENST00000348959:LtoR;ENST00000359142:LtoR;ENST000

ENST00000243997:YtoS;ENST00000395659:YtoS;ENST00000395663:YtoS;
ENST00000243997:YtoN;ENST00000395659:YtoN;ENST00000395663:YtoN;
ENST00000243997:ItoL;ENST00000395659:ItoL;ENST00000395663:ItoL;
ENST00000243997:*toY;ENST00000395659:*toY;ENST00000395663:*toY;

ENST00000292475:YtoH;ENST00000394186:YtoH;ENST00000449683:YtoH;

ENST00000264649:PtoQ;ENST00000343619:PtoQ;ENST00000393829:PtoQ;
ENST00000330342:QtoE;

ENST00000249289:ItoM;ENST00000492758:ItoM;
ENST00000249289:FtoS;ENST00000492758:FtoS;

ENST00000355221:StoR;ENST00000359530:StoR;ENST00000396774:StoR;ENST000
ENST00000355221:QtoP;ENST00000359530:QtoP;ENST00000396774:QtoP;ENST00

ENST00000341831:ItoL;ENST00000368489:ItoL;

ENST00000474627:LtoH;

ENST00000320211:QtoR;ENST00000346691:QtoR;ENST00000412052:QtoR;

50

+
+
+
+

+
+
+
+

+
+

+
+
+
+
+

+
+

+
+

+
+
+
+
+
+
+
+

+
+
+
+

+
+
+

+
+
+

+
+
+
+

TtoC
AtoG
GtoA
TtoA
TtoC
GtoT
TtoC
TtoC
AtoG
TtoC
AtoC
TtoG
TtoA
TtoC
AtoG
TtoA
TtoC
AtoC
GtoA
CtoA
TtoA
TtoC
TtoG
TtoA
CtoG
TtoC
GtoA
TtoC
TtoC
TtoG
AtoG
TtoA
AtoG
AtoG
TtoG
AtoG
AtoG
AtoC
TtoA
AtoC
AtoT
CtoT
AtoG
AtoG
AtoG
CtoT
TtoA
TtoC
AtoG
AtoG
CtoG
GtoA
TtoC
TtoC
TtoA
AtoG
TtoC
AtoG
CtoT
AtoG
AtoG
CtoA
CtoG
TtoA
TtoA
TtoC
AtoG
TtoC
TtoC
TtoG
AtoG
CtoG
TtoC
AtoG
TtoA
CtoA
TtoG
AtoC
AtoG
AtoG
TtoA
AtoC
GtoA
TtoC
AtoG
TtoC
TtoC
TtoA
CtoA
AtoC
AtoG
AtoC
AtoG
TtoA
TtoC
TtoA

0.1
0.1
0.15
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1429
0.1
0.1
0.1081
0.1
0.1
0.1
0.1176
0.1163
0.1111
0.1
0.1
0.1
0.1111
0.1333
0.1
0.1429
0.1
0.1
0.1
0.1
0.1818
0.1053
0.1
0.1562
0.1042
0.1163
0.2
0.1071
0.1094
0.119
0.1
0.1429
0.1
0.1
0.1
0.1
0.1
0.8333
0.1087
0.1176
0.1
0.1034
0.1739
0.1143
0.1
0.1053
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.1818
0.1
0.38
0.1
0.1
0.2
0.1
0.1
0.1
0.1333
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1
0.1
0.1029
0.1
0.1
0.1

0.1111
0.25
0.2857
0.1875
0.1
0.1053
0.1
0.1053
0.1333
0.1
0.1667
0.2727
0.3333
0.1818
0.1818
0.1538
0.1176
0.15
0.1
0.1
0.3
0.1429
0.2933
0.1667
0.125
0.1
0.1818
0.2632
0.1538
0.1429
0.1667
0.1
0.1538
0.1
0.125
0.3636
0.1304
0.2727
0.2
0.1818
0.2027
0.3
0.1316
0.125
0.2987
0.1
0.2
0.1875
0.1273
0.2
0.2143
0.1053
1
0.35
0.2727
0.1429
0.114
0.1905
0.1463
0.2
0.1818
0.1
0.2308
0.1111
0.1818
0.2143
0.1429
0.1
0.4615
0.1538
0.587
0.1
0.3636
0.2
0.2
0.1538
0.1111
0.1429
0.1538
0.1481
0.1667
0.1
0.1111
0.1
0.1818
0.1364
0.1875
0.125
0.1
0.2593
0.1
0.1
0.1176
0.1176
0.1176
0.1

2
3
7
7
2
3
3
2
2
2
3
5
4
3
3
2
6
3
2
2
2
3
6
7
2
3
9
15
6
3
2
3
5
2
6
4
9
3
7
4
6
6
6
12
16
4
4
6
7
7
9
5
5
17
7
6
7
5
5
4
5
4
5
2
4
2
3
3
5
3
7
2
3
2
5
2
2
8
3
2
2
4
3
2
3
7
8
3
2
3
3
2
5
4
2
2

2
2
2
3
2
2
2
2
2
2
2
3
4
2
2
2
3
3
2
2
2
2
2
2
2
2
5
7
2
2
2
2
3
2
2
4
4
2
3
2
4
3
2
2
15
2
2
3
2
3
4
2
5
10
3
2
2
2
2
3
2
2
4
2
2
2
3
2
3
2
7
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
5
2
2
2
2
2
2
2
2
2

[10,19]
[10,17]
[14,20]
[17,36]
[10,10]
[10,19]
[10,10]
[10,19]
[10,15]
[10,10]
[12,27]
[22,30]
[10,12]
[12,20]
[11,14]
[10,13]
[10,18]
[14,37]
[10,10]
[10,10]
[10,10]
[14,17]
[43,75]
[12,18]
[10,16]
[10,10]
[10,20]
[14,44]
[13,15]
[10,14]
[12,14]
[10,10]
[10,13]
[10,10]
[10,16]
[10,13]
[16,24]
[11,31]
[10,58]
[22,49]
[45,116]
[15,45]
[28,38]
[56,64]
[31,101]
[50,90]
[10,14]
[10,20]
[56,60]
[10,19]
[11,18]
[19,20]
[10,26]
[13,46]
[11,17]
[10,14]
[119,152]
[23,24]
[35,41]
[10,10]
[11,19]
[10,10]
[13,30]
[10,19]
[10,11]
[14,21]
[10,14]
[10,10]
[11,14]
[10,14]
[50,93]
[10,20]
[10,11]
[10,10]
[10,30]
[10,13]
[10,18]
[15,16]
[13,19]
[10,27]
[10,12]
[10,20]
[10,10]
[10,11]
[10,11]
[10,23]
[30,54]
[10,16]
[10,10]
[15,30]
[10,10]
[10,10]
[17,73]
[10,18]
[10,17]
[10,10]

TableS10

chr16:28755984
chr1:109835725
chr17:39630550
chr17:39630559
chr2:74607286
chr20:54394923
chr20:54394903
chr20:54378954
chr20:54381921
chr7:69869250
chr7:69894297
chr15:31950443
chr15:31946053
chr7:32874426
chr7:32874431
chr7:32875472
chr7:32876887
chr7:33020279
chr17:76786610
chr8:103910812
chr8:103910813
chr15:42797611
chr15:42791000
chr15:42791002
chr15:42791019
chr15:42791020
chr1:233680195
chr2:231973401
chr9:33102787
chr1:44223273
chr3:120413607
chr5:176969532
chr14:103096980
chr15:38543409
chr15:38541418
chr16:1339246
chr16:86668321
chr2:215301803
chr5:17329741
chr5:17329742
chr6:31611139
chr6:31606044
chr6:31713480
chr1:169824161
chr1:169827349
chr9:133324507
chr9:133341305
chr9:133363085
chr9:133363945
chr9:133364703
chr6:31714807
chr6:31714811
chr1:210926502
chr19:54155954
chr19:54156835
chr14:34340105
chr14:34293838
chr14:34365030
chr14:34333806
chr7:72494429
chr12:55297583
chr12:55316234
chr12:55276872
chr12:55278023
chr2:159948369
chr3:108949517
chr3:108974545
chr3:109007318
chr3:109008111
chr7:107023576
chr16:73820739
chr16:73820773
chr12:24886323
chr12:24855651
chr12:24855752
chr12:24860543
chr10:127531859
chr16:31031389
chr18:58941947
chr18:58942148
chr18:58943301
chr18:58944711
chr18:58944712
chr18:58945266
chr18:58945313
chr18:58945345
chr18:58946100
chr18:59137683
chr15:78040528
chr15:78040321
chr15:78040326
chr22:16590463
chr14:22850238
chr16:30806649
chr11:118274166
chr22:21933647

ATXN2L
ATXN7L2
ATXN7L3
ATXN7L3
AUP1
AURKA
AURKA
AURKA
AURKA
AUTS2
AUTS2
AVEN
AVEN
AVL9
AVL9
AVL9
AVL9
AVL9
AZI1
AZIN1
AZIN1
B2M
B2M
B2M
B2M
B2M
B3GALNT2
B3GNT7
B4GALT1
B4GALT2
B4GALT4
B4GALT7
BAG5
BAHD1
BAHD1
BAIAP3
BANP
BARD1
BASP1
BASP1
BAT1
BAT1
BAT2
BAT2D1
BAT2D1
BAT2L
BAT2L
BAT2L
BAT2L
BAT2L
BAT3
BAT3
BATF3
BAX
BAX
BAZ1A
BAZ1A
BAZ1A
BAZ1A
BAZ1B
BAZ2A
BAZ2A
BAZ2A
BAZ2A
BAZ2B
BBX
BBX
BBX
BBX
BCAP29
BCAR1
BCAR1
BCAT1
BCAT1
BCAT1
BCAT1
BCCIP
BCKDK
BCL2
BCL2
BCL2
BCL2
BCL2
BCL2
BCL2
BCL2
BCL2
BCL2
BCL2A1
BCL2A1
BCL2A1
BCL2L13
BCL2L2
BCL7C
BCL9L
BCR

UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR5
UTR5
UTR5
UTR5
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
mixed
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
mixed
mixed
UTR3
UTR3
coding_exon
mixed
mixed
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
mixed
UTR3
UTR3
UTR3
UTR3
mixed
mixed
coding_exon

ENST00000369869:KtoE;ENST00000369870:KtoE;

ENST00000312783:VtoA;ENST00000347343:VtoA;ENST00000371356:VtoA;ENST00
ENST00000312783:RtoW;ENST00000347343:RtoW;ENST00000371356:RtoW;ENST0

ENST00000269392:LtoP;ENST00000374782:LtoP;ENST00000450824:LtoP;
ENST00000337198:StoG;ENST00000347770:StoG;

ENST00000309519:QtoH;ENST00000356836:QtoH;ENST00000372324:QtoH;ENST0

ENST00000337322:ItoN;
ENST00000339351:TtoA;ENST00000416165:TtoA;ENST00000442618:TtoA;
ENST00000339351:LtoP;ENST00000416165:LtoP;ENST00000442618:LtoP;

ENST00000322611:NtoK;
ENST00000322611:EtoK;
ENST00000376177:RtoH;ENST00000396172:RtoH;ENST00000415382:RtoH;ENST00

ENST00000338920:TtoP;ENST00000345788:NtoT;ENST00000367742:TtoP;ENST000

ENST00000358716:KtoE;ENST00000360310:KtoE;ENST00000382422:KtoE;
ENST00000358716:ItoV;ENST00000360310:ItoV;ENST00000382422:ItoV;
ENST00000358716:EtoG;ENST00000360310:EtoG;ENST00000382422:EtoG;

ENST00000343439:LtoP;ENST00000355831:LtoP;ENST00000392782:LtoP;ENST0000

ENST00000005259:TtoS;ENST00000379117:TtoS;ENST00000379119:TtoS;ENST0000

ENST00000305877:KtoE;ENST00000359540:KtoE;

51

+
+

+
+

+
+
+
+
+

+
+
+
+
+

+
+
+
+

+
+

+
+
+
+
+
+
+
+

+
+

+
+
+
+
+

+
+

+
+

GtoA
AtoG
TtoA
AtoG
GtoA
TtoC
CtoT
AtoC
AtoG
TtoC
GtoA
TtoC
TtoG
GtoC
CtoT
AtoG
AtoG
TtoC
TtoC
AtoG
AtoG
AtoG
GtoC
CtoG
GtoC
AtoT
GtoC
GtoA
AtoG
AtoC
TtoG
TtoG
TtoA
AtoG
TtoC
TtoC
GtoT
CtoG
TtoA
GtoA
GtoA
AtoG
TtoC
AtoC
GtoA
AtoG
TtoC
AtoG
AtoG
TtoG
AtoG
TtoC
TtoA
TtoG
CtoG
AtoG
AtoG
AtoG
TtoC
GtoA
AtoG
GtoA
TtoG
AtoG
TtoC
TtoC
GtoC
AtoG
TtoA
AtoT
TtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
CtoA
TtoA
TtoC
AtoT
TtoA
TtoG
TtoC
CtoA
TtoC
GtoA
AtoG
TtoA
AtoG
TtoC
TtoC
AtoT
TtoG
AtoG
AtoG

0.1111
0.1
0.1389
0.1176
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.125
0.1
0.1333
0.1
0.1
0.1538
0.1
0.1
0.1226
0.101
0.1026
0.2353
0.3571
0.102
0.1054
0.1
0.1
0.1
0.1429
0.1
0.1176
0.1
0.1
0.1333
0.1818
0.1
0.1
0.1064
0.129
0.119
0.1053
0.125
0.1
0.1053
0.125
0.1
0.1111
0.1154
0.3
0.1111
0.1
0.1
0.1349
0.1
0.1071
0.125
0.1333
0.1
0.1429
0.1538
0.1818
0.1111
0.1
0.1176
0.1667
0.1
0.1
0.1
0.1
0.125
0.1
0.1111
0.1
0.1053
0.1
0.1667
0.1333
0.125
0.1136
0.1
0.15
0.125
0.1111
0.1
0.1
0.125
0.1111
0.1053
0.1304
0.1169
0.1
0.1
0.1
0.1333
0.1

0.1905
0.1333
0.3684
0.3036
0.1
0.2083
0.1579
0.1111
0.1538
0.1111
0.1
0.1667
0.1818
0.1667
0.1176
0.1
0.3
0.1176
0.1176
0.3708
0.1011
0.2143
0.3636
0.9259
0.2035
0.3649
0.1
0.1053
0.1818
0.1905
0.1538
0.1667
0.125
0.1176
0.1538
0.1818
0.1667
0.1
0.1071
0.1333
0.2308
0.1667
0.1429
0.3043
0.1765
0.1667
0.1429
0.1224
0.1667
0.4706
0.1818
0.1
0.1579
0.1767
0.1667
0.1579
0.1667
0.1667
0.1026
0.1667
0.1667
0.3333
0.3
0.1
0.125
0.1667
0.1111
0.1667
0.1
0.1
0.1429
0.1
0.125
0.1
0.1111
0.1429
0.2
0.2727
0.1818
0.1351
0.1
0.1538
0.1538
0.125
0.3
0.1538
0.125
0.1429
0.1429
0.4
0.4
0.1667
0.1
0.1667
0.2
0.1

6
2
14
13
3
5
5
2
2
2
3
3
3
3
2
3
2
3
2
17
5
8
3
16
12
14
4
2
5
4
2
2
4
2
3
3
4
3
7
3
4
5
4
6
6
2
2
7
2
2
4
4
6
4
3
5
7
12
9
4
2
3
6
3
4
2
3
3
3
2
2
3
4
3
4
2
3
4
4
9
2
5
7
6
11
3
4
3
6
5
8
8
2
3
2
2

3
2
11
11
3
3
3
2
2
2
3
2
2
2
2
2
2
2
2
10
2
6
2
16
4
11
2
2
2
2
2
2
3
2
2
2
2
2
2
3
2
3
2
5
2
2
2
3
2
2
2
2
2
4
2
2
2
4
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
3
2
7
2
2
2
3
4
6
4
2
2
2
2

[16,21]
[15,20]
[10,72]
[21,81]
[10,10]
[17,24]
[11,21]
[10,18]
[10,13]
[10,27]
[10,11]
[12,16]
[11,11]
[12,15]
[10,17]
[10,10]
[10,13]
[10,17]
[11,17]
[20,128]
[89,99]
[14,52]
[11,17]
[10,65]
[98,324]
[112,582]
[10,10]
[10,19]
[10,12]
[15,21]
[10,13]
[12,17]
[10,16]
[10,17]
[13,15]
[11,11]
[10,12]
[10,10]
[28,48]
[15,46]
[52,84]
[12,25]
[16,21]
[10,24]
[17,19]
[12,16]
[10,14]
[18,49]
[18,26]
[10,17]
[10,11]
[10,10]
[10,19]
[108,318]
[10,12]
[19,29]
[12,16]
[12,16]
[20,78]
[19,28]
[12,13]
[11,12]
[10,19]
[10,10]
[16,17]
[12,18]
[11,18]
[10,12]
[10,10]
[10,10]
[14,16]
[10,10]
[10,17]
[10,10]
[20,36]
[10,14]
[10,12]
[10,15]
[11,17]
[37,45]
[10,10]
[13,20]
[13,20]
[18,24]
[10,27]
[10,13]
[16,16]
[22,27]
[17,41]
[11,23]
[10,77]
[20,29]
[10,10]
[10,18]
[15,15]
[10,11]

TableS10

chr2:219234174
chr2:219233054
chr2:219233908
chr17:38216135
chr16:14651163
chr16:14656426
chr16:14656427
chr9:94514501
chr22:16596939
chr8:22537384
chr11:101738866
chr11:101753527
chr11:101724956
chr11:101713057
chr11:101713062
chr11:101699446
chr17:73732617
chr2:32604149
chr2:32543185
chr2:32546242
chr2:32591549
chr20:35580977
chr15:89155557
chr15:89153444
chr15:89159564
chr10:97957645
chr10:97941486
chr12:54399743
chr12:54399749
chr10:102030756
chr19:50376597
chr7:43813453
chr19:45645561
chr15:38171011
chr14:53486382
chr10:42612512
chr10:42617671
chr10:42612534
chr15:57752218
chr15:57742801
chr10:133636610
chr4:13212472
chr4:13209670
chr4:13210336
chr4:13212562
chr4:13211673
chr4:13211859
chr2:74216147
chr2:74216150
chr7:134014547
chr6:3097897
chr1:218297821
chr17:63338973
chr17:63331327
chr17:63339727
chr7:140124301
chr12:110580934
chr12:110587859
chr17:38497514
chr17:38453188
chr17:38451234
chr17:38450248
chr13:31870541
chr6:33051844
chr6:33051159
chr6:33056699
chr9:135905466
chr9:135889750
chr16:48946222
chr16:48912134
chr16:48946217
chr5:137520636
chr5:944832
chr5:944834
chr2:28374804
chr12:124076149
chr11:65864219
chr11:65861449
chr3:9757582
chr3:9756542
chr11:62214851
chr1:32603892
chr19:523628
chr19:534449
chr19:17374757
chr19:17374758
chr10:93757951
chr10:93760833
chr10:93760849
chr16:3572633
chr1:201543867
chr1:201543876
chr1:201544476
chr1:201545349
chr3:113666014
chr3:113666639

BCS1L
BCS1L
BCS1L
BECN1
BFAR
BFAR
BFAR
BICD2
BID
BIN3
BIRC2
BIRC2
BIRC2
BIRC3
BIRC3
BIRC3
BIRC5
BIRC6
BIRC6
BIRC6
BIRC6
BLCAP
BLM
BLM
BLM
BLNK
BLNK
BLOC1S1
BLOC1S1
BLOC1S2
BLOC1S3
BLVRA
BLVRB
BMF
BMP4
BMS1
BMS1
BMS1
BNIP2
BNIP2
BNIP3
BOD1L
BOD1L
BOD1L
BOD1L
BOD1L
BOD1L
BOLA3
BOLA3
BPGM
BPHL
BPNT1
BPTF
BPTF
BPTF
BRAF
BRAP
BRAP
BRCA1
BRCA1
BRCA1
BRCA1
BRCA2
BRD2
BRD2
BRD2
BRD3
BRD3
BRD7
BRD7
BRD7
BRD8
BRD9
BRD9
BRE
BRI3BP
BRMS1
BRMS1
BRPF1
BRPF1
BSCL2
BSDC1
BSG
BSG
BST2
BST2
BTAF1
BTAF1
BTAF1
BTBD12
BTG2
BTG2
BTG2
BTG2
BTLA
BTLA

coding_exon
UTR5
UTR5
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR5
UTR3
UTR3
UTR5
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
mixed
UTR3
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3

ENST00000359273:TtoS;ENST00000392109:TtoS;ENST00000392110:TtoS;ENST0000

ENST00000261658:VtoG;ENST00000426842:VtoG;
ENST00000261658:LtoW;ENST00000426842:LtoW;

ENST00000276416:ItoL;
ENST00000227758:QtoR;
ENST00000227758:NtoS;

ENST00000261359:NtoS;ENST00000421745:NtoS;

ENST00000414542:QtoR;
ENST00000355112:RtoS;

ENST00000358848:TtoA;ENST00000361832:TtoA;ENST00000370372:TtoA;ENST000

ENST00000374518:EtoG;
ENST00000374518:DtoE;
ENST00000267859:DtoG;ENST00000409352:DtoG;ENST00000415213:DtoG;
ENST00000368636:PtoR;
ENST00000040738:MtoT;
ENST00000040738:ItoK;
ENST00000040738:EtoG;
ENST00000040738:DtoG;

ENST00000306378:LtoP;ENST00000321892:LtoP;ENST00000335221:LtoP;

ENST00000327551:LtoV;ENST00000419234:LtoV;
ENST00000327551:HtoP;ENST00000419234:HtoP;
ENST00000309486:StoI;ENST00000346315:StoI;ENST00000353540:StoI;ENST00000
ENST00000309486:HtoP;ENST00000346315:HtoP;ENST00000351666:HtoP;ENST00

ENST00000374825:VtoA;ENST00000374831:VtoA;ENST00000395287:VtoA;ENST00
ENST00000374825:KtoN;ENST00000374831:KtoN;ENST00000395287:KtoN;ENST00
ENST00000303407:TtoP;ENST00000357885:TtoP;ENST00000371834:TtoP;
ENST00000394688:StoC;ENST00000394689:StoC;ENST00000401491:StoC;
ENST00000394688:LtoR;ENST00000394689:LtoR;
ENST00000394688:AtoS;ENST00000394689:AtoS;ENST00000401491:AtoS;

ENST00000359957:StoP;ENST00000425825:StoP;
ENST00000302054:LtoP;ENST00000383829:LtoP;ENST00000424362:LtoP;ENST0000
ENST00000302054:KtoE;ENST00000383829:KtoE;ENST00000424362:KtoE;ENST000
ENST00000278893:KtoR;

ENST00000265990:KtoR;
ENST00000265990:HtoR;
ENST00000294008:EtoG;

52

+
+
+

+
+
+

+
+
+
+
+
+
+
+
+
+
+

+
+
+

+
+

+
+

+
+
+

+
+

+
+
+

+
+
+
+

+
+

+
+

+
+

+
+
+

+
+
+
+

AtoT
AtoG
TtoA
TtoC
TtoG
TtoG
GtoA
TtoA
GtoA
AtoC
AtoG
AtoG
AtoC
CtoG
TtoC
AtoG
TtoC
AtoG
TtoC
AtoG
TtoA
AtoG
AtoC
TtoC
AtoC
GtoA
TtoA
CtoG
TtoC
AtoG
AtoG
TtoC
AtoG
TtoG
TtoC
AtoG
TtoG
TtoG
AtoG
TtoC
CtoG
TtoC
TtoA
AtoG
AtoG
AtoG
TtoC
AtoC
AtoG
GtoT
TtoC
TtoC
TtoC
TtoG
AtoG
TtoC
TtoG
AtoC
GtoT
AtoC
AtoC
TtoG
AtoG
TtoC
AtoC
CtoG
AtoC
AtoG
CtoG
TtoG
GtoT
AtoG
AtoG
AtoG
CtoA
TtoC
TtoC
TtoC
TtoC
AtoG
AtoG
TtoC
GtoA
TtoC
GtoA
AtoG
AtoG
AtoG
TtoG
AtoG
AtoG
AtoG
AtoG
AtoC
TtoG
AtoG

0.1667
0.1
0.1
0.1034
0.1
0.1429
0.125
0.1
0.1
0.1
0.125
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1111
0.1
0.1
0.1034
0.1111
0.1
0.1
0.1068
0.1333
0.2
0.1818
0.1
0.1
0.1364
0.1034
0.1
0.1176
0.1
0.1
0.2
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1538
0.1
0.1
0.1
0.1
0.1
0.1333
0.1429
0.1
0.1
0.1
0.1176
0.4545
0.1
0.1
0.1154
0.1176
0.1
0.125
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.6
0.1
0.9954
0.1146
0.1
0.1071
0.1
0.1
0.1333
0.1
0.1053
0.1
0.1
0.1111
0.1429
0.1

0.1818
0.1818
0.1
0.1429
0.1667
0.1429
0.1333
0.125
0.1
0.1333
0.1875
0.1818
0.1
0.1429
0.1818
0.1333
0.1429
0.1538
0.1538
0.1818
0.1
0.1875
0.125
0.1
0.1
0.165
0.2
0.3125
0.4247
0.1
0.1
0.1818
0.1176
0.1818
0.2
0.1053
0.2143
0.2222
0.1053
0.2
0.1
0.1
0.1818
0.1
0.1
0.1176
0.1
0.2
0.2
0.1
0.2
0.1
0.1111
0.2
0.1667
0.25
0.1667
0.2667
0.1
0.2
0.2857
0.1333
0.1
0.125
0.1765
0.5125
0.1
0.2143
0.1333
0.1429
0.1034
0.1429
0.1333
0.1176
0.125
0.125
0.1176
0.1818
0.1
0.125
0.7692
0.2
1
0.1447
0.1333
0.2727
0.1667
0.1053
0.1765
0.1
0.3056
0.2941
0.15
0.1111
0.1818
0.125

4
4
3
6
9
5
2
2
2
2
6
2
2
3
2
2
4
2
2
2
6
6
5
5
2
14
4
6
4
3
2
9
4
3
2
3
10
4
3
2
2
4
4
2
2
3
2
2
7
2
3
3
4
4
2
2
3
7
2
3
4
2
2
3
6
2
2
3
2
8
2
5
4
3
2
3
2
10
2
4
2
3
8
5
3
11
5
3
3
4
7
8
3
2
3
4

2
2
2
2
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
5
2
2
2
7
3
3
3
3
2
2
2
2
2
3
5
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
5
2
2
4
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
4
2
2
2
2
8
4
2
5
3
2
2
2
5
7
2
2
2
2

[11,12]
[10,11]
[10,10]
[14,29]
[10,18]
[14,14]
[15,16]
[16,20]
[10,10]
[10,15]
[16,16]
[10,11]
[10,10]
[10,14]
[10,11]
[10,15]
[10,14]
[10,13]
[13,18]
[10,11]
[10,10]
[16,44]
[10,16]
[10,10]
[10,10]
[37,176]
[11,16]
[12,20]
[11,77]
[10,10]
[10,10]
[11,23]
[17,29]
[10,11]
[10,17]
[10,19]
[10,69]
[10,15]
[19,20]
[10,10]
[10,10]
[10,10]
[10,11]
[10,10]
[10,10]
[10,17]
[10,10]
[10,10]
[10,10]
[10,10]
[10,10]
[10,10]
[10,18]
[13,15]
[10,12]
[10,12]
[10,12]
[10,15]
[10,20]
[10,15]
[13,15]
[10,15]
[10,10]
[10,16]
[17,17]
[155,160]
[10,10]
[10,14]
[15,26]
[14,18]
[10,29]
[14,16]
[10,15]
[17,18]
[16,20]
[10,16]
[10,17]
[10,15]
[10,10]
[10,16]
[13,40]
[10,10]
[31,294]
[51,115]
[10,15]
[11,28]
[10,14]
[10,19]
[15,17]
[10,10]
[15,36]
[13,50]
[10,20]
[10,10]
[11,14]
[10,16]

TableS10

chr3:113667086
chr6:26576421
chr6:26499056
chr6:26499169
chr6:26519784
chr6:26521298
chr6:26521341
chr6:26513657
chr6:26483004
chr6:26485464
chr10:103303344
chr2:111112186
chr2:111140447
chr11:116138642
chr11:116146067
chr5:34961342
chr1:84734566
chr1:84735774
chr1:84735894
chr6:42008149
chr6:42008743
chr2:201391338
chr2:201391343
chr10:73660130
chr10:73663032
chr10:121585098
chr10:121580899
chr10:121580933
chr10:97617660
chr10:97622470
chr10:97626380
chr10:127428036
chr10:5840915
chr10:5830542
chr10:5843265
chr10:102739392
chr10:102743158
chr10:102743921
chr10:104613583
chr10:95441830
chr10:120431211
chr10:120431215
chr10:120432080
chr10:120432613
chr10:120435546
chr10:120435629
chr10:73180749
chr10:103751819
chr10:103595391
chr10:103596425
chr10:103596961
chr10:120085741
chr10:104200072
chr11:111259827
chr11:61313186
chr11:61316633
chr11:61316640
chr11:64621101
chr11:64635749
chr11:30309380
chr11:62191574
chr11:62191572
chr11:62189698
chr11:47140236
chr11:71499978
chr11:71499980
chr11:111456396
chr11:111460047
chr11:65440908
chr11:60970353
chr12:51987184
chr12:105891276
chr12:109410051
chr12:109412386
chr12:110969949
chr12:110950603
chr12:2864799
chr12:2867463
chr12:2867892
chr12:2868384
chr12:2868700
chr12:32036633
chr12:47361581
chr12:47333584
chr12:119926147
chr12:119926151
chr12:119926152
chr12:50757244
chr12:103912600
chr12:103912585
chr12:103912586
chr12:102869249
chr13:38485502
chr13:38482997
chr13:20626234
chr13:20648659

BTLA
BTN2A1
BTN2A2
BTN2A2
BTN3A1
BTN3A1
BTN3A1
BTN3A1
BTN3A2
BTN3A2
BTRC
BUB1
BUB1
BUD13
BUD13
BXDC2
BXDC5
BXDC5
BXDC5
BYSL
BYSL
BZW1
BZW1
C10orf104
C10orf104
C10orf119
C10orf119
C10orf119
C10orf131
C10orf131
C10orf131
C10orf137
C10orf18
C10orf18
C10orf18
C10orf2
C10orf2
C10orf2
C10orf32
C10orf4
C10orf46
C10orf46
C10orf46
C10orf46
C10orf46
C10orf46
C10orf54
C10orf76
C10orf76
C10orf76
C10orf76
C10orf84
C10orf95
C11orf1
C11orf10
C11orf10
C11orf10
C11orf2
C11orf2
C11orf46
C11orf48
C11orf48
C11orf48
C11orf49
C11orf51
C11orf51
C11orf57
C11orf57
C11orf68
C11orf79
C12orf10
C12orf23
C12orf24
C12orf24
C12orf30
C12orf30
C12orf32
C12orf32
C12orf32
C12orf32
C12orf32
C12orf35
C12orf41
C12orf41
C12orf43
C12orf43
C12orf43
C12orf44
C12orf45
C12orf45
C12orf45
C12orf73
C13orf23
C13orf23
C13orf3
C13orf3

UTR3
mixed
coding_exon
coding_exon
coding_exon
mixed
mixed
UTR5
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
mixed
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR5
UTR5
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR5
UTR5
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR5

ENST00000302759:NtoD;ENST00000409311:NtoD;
ENST00000302759:HtoR;ENST00000409311:HtoR;

ENST00000230340:DtoE;
ENST00000353957:StoP;ENST00000409226:StoP;ENST00000409521:StoP;ENST000
ENST00000299381:DtoG;
ENST00000360003:ItoV;ENST00000369077:ItoV;

ENST00000263123:WtoR;ENST00000328090:WtoR;ENST00000380270:WtoR;ENST0
ENST00000263123:NtoD;ENST00000328090:NtoD;ENST00000380270:NtoD;ENST00
ENST00000263123:DtoE;ENST00000328090:DtoE;ENST00000380270:DtoE;ENST000

ENST00000359204:LtoV;ENST00000371426:LtoV;ENST00000371430:LtoV;ENST000

ENST00000370033:VtoD;

ENST00000279281:RtoQ;

ENST00000354588:EtoK;ENST00000415855:EtoK;ENST00000431002:EtoK;
ENST00000354588:EtoD;ENST00000415855:EtoD;ENST00000431002:EtoD;

ENST00000280352:PtoQ;ENST00000393047:PtoQ;ENST00000393048:PtoQ;ENST00

ENST00000267103:LtoP;
ENST00000377673:ItoK;
ENST00000261745:StoP;ENST00000412551:StoP;

ENST00000312561:MtoR;ENST00000381054:MtoR;

ENST00000280749:KtoR;
ENST00000280749:AtoE;

53

+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+

+
+
+

+
+

+
+
+
+
+

+
+
+
+
+
+

+
+
+
+

TtoC
CtoT
TtoC
GtoA
GtoA
CtoT
TtoC
AtoG
TtoA
AtoC
TtoC
AtoG
AtoG
AtoG
AtoG
TtoC
TtoC
AtoT
TtoA
TtoA
AtoG
TtoC
TtoC
AtoG
AtoG
AtoG
AtoG
AtoG
CtoA
GtoA
TtoA
AtoG
TtoA
AtoG
TtoG
GtoT
CtoA
TtoC
AtoC
CtoG
AtoG
TtoG
AtoG
TtoG
CtoG
TtoG
AtoG
TtoA
TtoC
GtoT
TtoA
GtoA
TtoA
TtoC
TtoA
GtoC
TtoG
GtoA
GtoA
TtoA
GtoA
GtoC
AtoG
AtoC
TtoC
TtoG
CtoA
GtoA
TtoC
GtoT
TtoC
TtoC
TtoA
TtoC
TtoC
TtoC
TtoC
TtoC
AtoG
AtoC
GtoA
TtoG
AtoG
TtoG
TtoG
AtoG
TtoG
GtoC
AtoG
CtoA
AtoG
AtoG
TtoG
AtoG
TtoA
TtoG

0.125
0.1429
0.1667
0.1429
0.1
0.1176
0.2
0.1
0.1
0.1053
0.1
0.1
0.1111
0.1
0.1333
0.1
0.1176
0.1
0.1
0.1
0.1111
0.1053
0.1
0.1034
0.1154
0.1333
0.1053
0.1
0.2727
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1667
0.2143
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1
0.1
0.1
0.1
0.1071
0.1538
0.1163
0.1333
0.1
0.1538
0.2857
0.1
0.1429
0.1154
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1538
0.1
0.1071
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.2308
0.1538
0.1
0.1
0.125
0.1034
0.1
0.1429
0.1
0.1
0.1429

0.1667
0.1538
0.6
0.2353
0.1364
0.4545
0.2308
0.1
0.2308
0.2143
0.1
0.1429
0.1667
0.1333
0.15
0.1667
0.1667
0.1333
0.1111
0.1053
0.2143
0.1429
0.1154
0.1311
0.1395
0.1707
0.2
0.125
0.2727
0.1
0.1333
0.1579
0.1
0.1
0.1
0.2273
0.1
0.2
0.2
0.1111
0.1818
0.2857
0.1
0.1
0.1
0.1
0.1
0.1667
0.1154
0.1
0.2
0.1
0.2143
0.1667
0.1818
0.1489
0.2
0.1667
0.2308
0.1
0.7273
0.9231
0.1818
0.1667
0.1613
0.1875
0.15
0.1
0.1333
0.1
0.1
0.1304
0.1
0.1
0.1
0.1818
0.1053
0.1364
0.1667
0.1
0.1176
0.1538
0.1
0.1111
0.1111
0.25
0.3077
0.1111
0.3077
0.1765
0.1667
0.1667
0.1667
0.1818
0.1111
0.1538

2
3
5
4
3
3
4
2
15
7
2
8
2
6
2
2
4
4
5
2
3
2
2
12
8
7
2
4
3
2
3
9
2
3
2
2
2
6
2
2
4
5
2
2
2
2
2
5
2
2
4
2
4
4
6
3
2
3
2
2
9
17
3
6
9
5
2
3
5
2
4
4
8
2
3
3
7
7
6
3
4
3
2
3
2
2
3
2
4
8
9
2
2
2
3
2

2
2
5
4
2
3
3
2
8
3
2
4
2
3
2
2
2
2
3
2
2
2
2
4
2
5
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
9
17
3
2
3
2
2
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
3
2
3
3
3
2
2
2
2
2

[12,16]
[13,14]
[10,18]
[14,18]
[10,22]
[11,17]
[10,13]
[10,10]
[13,48]
[14,29]
[10,10]
[10,28]
[18,18]
[10,17]
[15,20]
[18,20]
[12,17]
[10,15]
[10,21]
[19,20]
[14,18]
[14,19]
[10,26]
[28,82]
[43,57]
[12,41]
[10,20]
[10,33]
[11,11]
[10,10]
[10,16]
[10,20]
[10,10]
[10,10]
[10,10]
[10,22]
[10,10]
[10,10]
[10,10]
[10,18]
[11,24]
[14,18]
[10,10]
[10,10]
[10,10]
[10,10]
[10,10]
[10,12]
[10,26]
[10,10]
[10,15]
[10,10]
[10,14]
[10,12]
[10,18]
[28,50]
[11,13]
[12,43]
[13,15]
[10,10]
[10,21]
[11,34]
[10,11]
[18,21]
[19,31]
[16,32]
[10,20]
[10,10]
[15,20]
[10,20]
[10,20]
[10,23]
[10,11]
[10,10]
[10,10]
[11,13]
[10,19]
[22,28]
[12,16]
[10,10]
[17,20]
[10,13]
[10,10]
[10,20]
[10,10]
[12,13]
[12,13]
[10,18]
[10,20]
[13,17]
[12,29]
[10,19]
[12,14]
[10,11]
[10,18]
[13,14]

TableS10

chr14:89854159
chr14:75707996
chr14:22637270
chr14:22637521
chr14:22637526
chr14:76980404
chr14:59681376
chr14:59628665
chr14:92739805
chr14:89467672
chr14:103223300
chr14:103107859
chr14:103235225
chr14:103126619
chr14:103221730
chr14:90725199
chr14:90732562
chr14:90706147
chr14:90712031
chr14:75595465
chr14:103448386
chr14:103448604
chr14:103448606
chr14:23844240
chr14:23844640
chr14:76564279
chr14:73603336
chr14:105026168
chr14:105026169
chr15:72981460
chr15:72981461
chr15:72981995
chr15:73290916
chr15:87971903
chr15:63658296
chr16:1353257
chr16:76663
chr16:76664
chr16:66254824
chr16:66255097
chr16:79588420
chr16:19535543
chr16:15867132
chr16:15867935
chr16:8627111
chr16:65711576
chr16:11352244
chr16:11352284
chr16:56707516
chr16:87306587
chr16:45394058
chr16:19625740
chr16:1410021
chr17:77945572
chr17:26250461
chr17:16285584
chr17:16285958
chr17:16286054
chr17:10550595
chr17:39581919
chr17:39590756
chr17:39595170
chr17:7247024
chr17:8081538
chr17:8072554
chr17:8072847
chr17:8071883
chr17:8071991
chr17:8072117
chr17:77128089
chr17:77117583
chr17:54645631
chr17:27689088
chr17:27689412
chr17:27689087
chr17:7100906
chr17:7100904
chr17:72600965
chr17:5053058
chr17:76829673
chr17:76829675
chr17:34083024
chr18:32662818
chr18:13672014
chr18:31809042
chr18:46171502
chr18:42097053
chr18:42100679
chr18:45262205
chr18:69967078
chr19:4608604
chr19:4608606
chr19:34885578
chr19:34884885
chr19:847508
chr19:1425170

C14orf102
C14orf118
C14orf119
C14orf119
C14orf119
C14orf133
C14orf135
C14orf135
C14orf142
C14orf143
C14orf153
C14orf153
C14orf153
C14orf153
C14orf153
C14orf159
C14orf159
C14orf159
C14orf159
C14orf179
C14orf2
C14orf2
C14orf2
C14orf21
C14orf21
C14orf4
C14orf45
C14orf80
C14orf80
C15orf17
C15orf17
C15orf17
C15orf39
C15orf42
C15orf44
C16orf28
C16orf35
C16orf35
C16orf48
C16orf48
C16orf61
C16orf62
C16orf63
C16orf63
C16orf68
C16orf70
C16orf75
C16orf75
C16orf80
C16orf84
C16orf87
C16orf88
C16orf91
C17orf101
C17orf42
C17orf45
C17orf45
C17orf45
C17orf48
C17orf53
C17orf53
C17orf53
C17orf61
C17orf68
C17orf68
C17orf68
C17orf68
C17orf68
C17orf68
C17orf70
C17orf70
C17orf71
C17orf75
C17orf75
C17orf75
C17orf81
C17orf81
C17orf86
C17orf87
C17orf89
C17orf89
C17orf96
C18orf10
C18orf19
C18orf21
C18orf24
C18orf25
C18orf25
C18orf32
C18orf55
C19orf10
C19orf10
C19orf12
C19orf12
C19orf22
C19orf25

mixed
coding_exon
mixed
mixed
mixed
coding_exon
coding_exon
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
mixed
mixed
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
UTR3
UTR3
mixed
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3

ENST00000261530:VtoA;ENST00000312858:VtoA;ENST00000336993:VtoA;ENST00

ENST00000327028:DtoY;ENST00000343765:DtoY;ENST00000445370:DtoY;ENST000

ENST00000306954:RtoQ;
ENST00000316738:KtoE;
ENST00000246489:GtoS;ENST00000334553:GtoS;ENST00000347839:GtoS;

ENST00000256324:VtoA;ENST00000321157:VtoA;ENST00000336843:VtoA;ENST00
ENST00000256324:QtoR;ENST00000321157:QtoR;ENST00000336843:QtoR;ENST00
ENST00000256324:GtoV;ENST00000321157:GtoV;ENST00000336843:GtoV;ENST00
ENST00000256324:EtoG;ENST00000321157:EtoG;ENST00000336843:EtoG;ENST000

ENST00000243878:StoG;ENST00000414445:StoG;
ENST00000243878:HtoR;ENST00000414445:HtoR;
ENST00000219400:NtoK;

ENST00000163678:NtoD;ENST00000381920:NtoD;
ENST00000219139:VtoA;

ENST00000262498:LtoP;

ENST00000219837:EtoG;ENST00000420899:EtoG;

ENST00000306049:DtoG;

ENST00000245382:QtoK;ENST00000319977:QtoK;

ENST00000327787:EtoD;
ENST00000300917:LtoI;
ENST00000225805:TtoP;
ENST00000225805:TtoK;
ENST00000225805:TtoI;
ENST00000354429:StoT;ENST00000356683:StoT;ENST00000396627:StoT;ENST0000
ENST00000354429:DtoE;ENST00000356683:DtoE;ENST00000396627:DtoE;ENST000

ENST00000322247:HtoQ;ENST00000402563:HtoQ;ENST00000457610:HtoQ;
ENST00000269194:StoP;ENST00000333234:StoP;
ENST00000285116:StoP;ENST00000398452:StoP;ENST00000417656:StoP;
ENST00000282059:DtoN;ENST00000321319:DtoN;

ENST00000169551:StoP;

ENST00000323670:DtoN;ENST00000392278:DtoN;

54

+
+
+
+

+
+

+
+
+
+
+
+
+
+
+
+

+
+

+
+
+

+
+

+
+
+
+

+
+
+
+
+
+
+

+
+
+

+
+

+
+
+
+

TtoC
TtoC
AtoG
TtoC
TtoA
GtoT
AtoT
TtoG
GtoA
AtoG
GtoA
AtoT
CtoG
GtoA
CtoG
TtoC
AtoG
GtoT
AtoG
AtoG
TtoC
TtoA
AtoG
TtoC
TtoC
AtoC
TtoC
AtoC
AtoG
CtoA
TtoC
GtoT
TtoA
TtoA
TtoC
TtoG
GtoT
GtoT
AtoG
AtoG
TtoG
TtoG
TtoC
TtoC
AtoG
TtoC
TtoA
AtoT
TtoC
CtoT
TtoC
AtoG
AtoG
TtoC
AtoG
TtoC
CtoG
TtoC
GtoC
CtoA
TtoA
TtoC
AtoG
AtoC
TtoC
TtoC
AtoG
TtoA
TtoG
GtoT
GtoC
TtoA
AtoC
CtoA
CtoT
GtoC
CtoG
TtoC
AtoG
TtoC
CtoA
TtoG
TtoA
TtoA
TtoC
TtoC
GtoA
TtoC
TtoC
TtoC
GtoT
GtoT
GtoA
AtoG
TtoC
TtoA

0.1
0.1
0.1
0.1154
0.1053
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1087
0.1111
0.1
0.1
0.1
0.1
0.1042
0.1538
0.1
0.2
0.1818
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1429
0.1
0.1667
0.1
0.1
0.1667
0.1
0.1
0.1
0.1
0.1
0.1176
0.1111
0.1
0.1
0.1
0.3973
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.2353
0.1
1
0.1
0.9167
0.1569
0.1622
0.1
0.1
0.1389
0.1
0.1538
0.1
0.1
0.1053
0.15
0.1
0.1
0.125
0.1176
0.1
0.1053
0.1
0.1111
0.1667
0.1

0.1111
0.1
0.1579
0.1154
0.1364
0.1111
0.1667
0.1
0.1
0.1
0.1429
0.1
0.1429
0.2
0.1333
0.1333
0.1429
0.1
0.1818
0.1
0.1333
0.1167
0.1231
0.1
0.1538
0.1429
0.1
0.1129
0.1556
0.1818
0.2
0.2667
0.1364
0.125
0.2
0.1
0.1333
0.1176
0.1429
0.1
0.16
0.1538
0.1875
0.1818
0.1
0.1818
0.1
0.1818
0.1429
0.4583
0.1
0.1333
0.1429
0.1
0.1667
0.1161
0.8087
0.25
0.1
0.1818
0.1
0.1176
0.3125
0.1
0.1333
0.1
0.1
0.1538
0.1
0.1111
0.2778
0.1
1
0.1
1
0.6
0.5833
0.2
0.1
0.1429
0.3636
0.2
0.1429
0.1429
0.1111
0.1875
0.1
0.1538
0.129
0.1875
0.1304
0.1333
0.1
0.1765
0.2
0.1

3
3
14
5
4
2
3
2
2
2
6
6
3
6
10
7
2
2
2
2
3
5
9
5
4
2
2
5
4
10
7
8
5
2
7
2
4
3
2
3
9
3
5
4
2
2
2
2
4
2
2
2
4
3
3
14
8
16
3
3
2
4
5
2
5
3
2
2
5
2
2
4
2
2
4
5
12
3
3
5
9
4
2
3
2
3
3
3
6
4
4
3
3
4
3
3

2
2
4
2
2
2
2
2
2
2
2
3
2
4
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
4
2
6
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
8
13
2
2
2
2
4
2
3
2
2
2
2
2
2
2
2
2
4
3
5
2
2
2
5
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2

[10,10]
[10,10]
[17,33]
[26,26]
[19,22]
[10,10]
[10,12]
[10,10]
[10,10]
[10,10]
[19,21]
[10,10]
[10,14]
[10,12]
[30,30]
[10,15]
[10,14]
[10,10]
[10,11]
[10,10]
[15,15]
[50,61]
[38,67]
[10,10]
[20,26]
[10,21]
[10,10]
[52,68]
[14,45]
[10,17]
[10,15]
[10,16]
[18,22]
[10,16]
[10,21]
[10,10]
[15,20]
[10,17]
[10,14]
[10,10]
[14,25]
[10,13]
[16,18]
[10,11]
[10,10]
[11,12]
[10,10]
[10,11]
[11,15]
[10,24]
[10,10]
[15,17]
[18,22]
[10,10]
[10,12]
[61,187]
[80,377]
[14,258]
[10,10]
[10,11]
[10,10]
[10,17]
[10,16]
[10,10]
[15,18]
[10,10]
[10,10]
[10,13]
[10,10]
[10,18]
[17,19]
[10,10]
[17,19]
[10,10]
[10,17]
[10,51]
[12,55]
[10,10]
[10,10]
[35,36]
[10,16]
[13,16]
[10,14]
[10,14]
[10,19]
[17,20]
[10,10]
[10,13]
[16,31]
[16,17]
[10,23]
[15,19]
[10,10]
[17,27]
[10,12]
[10,10]

TableS10

chr19:3574708
chr19:3561928
chr19:2049800
chr19:2049801
chr19:2049449
chr19:16618378
chr19:16618710
chr19:45526202
chr19:13750274
chr19:13750276
chr19:45939634
chr19:18561294
chr19:55678411
chr19:55678415
chr2:68123546
chr2:68127938
chr1:199134141
chr1:37921119
chr1:167944268
chr1:168068196
chr1:168085352
chr1:168089324
chr1:36558814
chr1:36557633
chr1:23984835
chr1:23984836
chr1:23986554
chr1:229441353
chr1:37732130
chr1:37731574
chr1:37731875
chr1:19825680
chr1:19825683
chr1:1007113
chr1:3795711
chr1:54980176
chr1:243083617
chr1:35952436
chr1:35952638
chr1:28085699
chr1:152445866
chr1:148515664
chr1:224238001
chr1:25441444
chr1:25441492
chr1:25441498
chr1:244877424
chr1:244896879
chr1:244897983
chr1:244897988
chr12:7140279
chr20:42131274
chr20:54527335
chr20:61047300
chr20:61047379
chr20:42259550
chr20:57954386
chr20:47339172
chr20:47339175
chr20:47339176
chr20:47339177
chr20:3682184
chr20:3752803
chr20:24902342
chr20:24892549
chr20:13730286
chr21:44581974
chr21:44576418
chr21:44378091
chr21:44389598
chr21:44389794
chr21:44390017
chr21:32563972
chr21:34679753
chr21:46546912
chr21:46561581
chr21:33053449
chr21:33053264
chr21:45177759
chr21:29469010
chr21:18087601
chr22:31125746
chr22:30408251
chr22:30408326
chr22:30408445
chr22:30408542
chr22:30408588
chr22:30408589
chr22:30409345
chr22:40809272
chr22:17811327
chr22:43968465
chr22:43968528
chr22:43968953
chr22:43968958
chr22:43969023

C19orf29
C19orf29
C19orf36
C19orf36
C19orf36
C19orf42
C19orf42
C19orf47
C19orf53
C19orf53
C19orf54
C19orf60
C19orf63
C19orf63
C1D
C1D
C1orf106
C1orf109
C1orf112
C1orf112
C1orf112
C1orf112
C1orf113
C1orf113
C1orf128
C1orf128
C1orf128
C1orf131
C1orf149
C1orf149
C1orf149
C1orf151
C1orf151
C1orf159
C1orf174
C1orf175
C1orf199
C1orf216
C1orf216
C1orf38
C1orf43
C1orf54
C1orf55
C1orf63
C1orf63
C1orf63
C1orf71
C1orf71
C1orf71
C1orf71
C1RL
C20orf100
C20orf106
C20orf11
C20orf11
C20orf111
C20orf177
C20orf199
C20orf199
C20orf199
C20orf199
C20orf27
C20orf29
C20orf3
C20orf3
C20orf7
C21orf2
C21orf2
C21orf33
C21orf33
C21orf33
C21orf33
C21orf45
C21orf51
C21orf58
C21orf58
C21orf66
C21orf66
C21orf67
C21orf7
C21orf91
C22orf28
C22orf30
C22orf30
C22orf30
C22orf30
C22orf30
C22orf30
C22orf30
C22orf32
C22orf39
C22orf9
C22orf9
C22orf9
C22orf9
C22orf9

coding_exon
mixed
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
mixed
UTR3
mixed
mixed
mixed
UTR3
coding_exon
mixed
coding_exon
coding_exon
UTR3
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
mixed
mixed
mixed
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
mixed
mixed
mixed
coding_exon
coding_exon
mixed
mixed
mixed
mixed
UTR3
mixed
coding_exon
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
mixed
mixed
coding_exon
coding_exon
UTR3
mixed
UTR3
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3

ENST00000221899:LtoR;ENST00000248420:LtoR;ENST00000429344:LtoR;
ENST00000300960:MtoK;ENST00000395301:MtoK;ENST00000395307:MtoK;
ENST00000300960:MtoI;ENST00000395301:MtoI;ENST00000395307:MtoI;
ENST00000300960:KtoR;ENST00000395301:KtoR;ENST00000395307:KtoR;

ENST00000357884:TtoA;ENST00000392035:TtoA;

ENST00000358607:HtoP;ENST00000397217:HtoP;ENST00000450195:HtoP;

ENST00000355848:NtoK;ENST00000407324:NtoK;ENST00000409302:NtoK;ENST00

ENST00000312808:QtoK;ENST00000426732:QtoK;ENST00000453908:QtoK;
ENST00000246151:GtoE;ENST00000374524:GtoE;

ENST00000318906:GtoV;ENST00000366648:GtoV;ENST00000366649:GtoV;ENST00

ENST00000366512:PtoL;ENST00000366513:PtoL;

ENST00000266542:StoR;

ENST00000358293:TtoP;ENST00000360816:TtoP;

ENST00000378106:LtoP;ENST00000463598:LtoP;
ENST00000325223:StoC;ENST00000339818:StoC;ENST00000397956:StoC;

ENST00000290130:StoP;

ENST00000290178:Lto*;ENST00000331923:Lto*;ENST00000342419:Lto*;
ENST00000290178:KtoQ;ENST00000331923:KtoQ;ENST00000342419:KtoQ;

ENST00000442204:RtoG;

55

+
+
+

+
+

+
+
+

+
+
+
+
+
+
+
+
+

+
+

+
+
+
+

+
+
+
+

+
+
+
+
+

+
+
+
+

TtoG
TtoC
TtoA
GtoC
AtoG
TtoA
AtoC
AtoG
TtoC
CtoA
CtoA
AtoC
TtoC
CtoA
TtoA
TtoG
AtoG
AtoG
AtoG
TtoG
TtoA
TtoG
CtoA
CtoA
GtoA
AtoT
AtoC
GtoT
GtoT
AtoC
TtoC
TtoC
TtoC
GtoA
AtoG
AtoC
TtoG
GtoA
CtoA
TtoC
TtoC
TtoG
AtoG
TtoA
GtoA
CtoA
CtoT
TtoC
TtoC
AtoG
CtoA
AtoG
TtoC
CtoA
CtoA
AtoG
AtoC
TtoC
AtoG
TtoA
AtoG
TtoA
GtoA
GtoA
TtoC
TtoC
AtoT
TtoG
TtoC
AtoT
AtoC
TtoG
TtoC
AtoG
TtoC
AtoT
TtoA
AtoC
CtoT
TtoC
CtoA
AtoG
GtoA
AtoG
TtoC
TtoC
GtoT
TtoG
CtoA
AtoG
AtoG
TtoC
AtoG
AtoG
AtoG
AtoG

0.1
1
0.1818
0.1
0.25
0.1
0.1
0.1176
0.1667
0.122
0.1
0.1176
0.1176
0.1176
0.1
0.1364
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1111
0.1111
0.1
0.1
0.1
0.1
0.1333
0.1
0.1351
0.1
0.1429
0.2
0.1
0.1
0.1
0.1
0.1471
0.1111
0.1
0.1034
0.1
0.1176
0.1
0.1
0.1176
0.1
0.1
0.1
0.1
0.1111
0.1111
0.12
0.1
0.1034
0.1429
0.1429
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.125
0.102
0.119
0.1333
0.1
0.1667
0.1667
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.3333
0.4545
0.3636
0.1

0.1
1
0.2143
0.2667
0.3333
0.1
0.1818
0.2
0.2
0.3636
0.1429
0.1515
0.1852
0.1538
0.125
0.2
0.125
0.1818
0.1053
0.1
0.2
0.1
0.1053
0.1429
0.1765
0.1765
0.1739
0.1
0.1
0.1
0.2
0.1818
0.3333
0.2
0.3
0.2
0.1176
0.1
0.1
0.1
0.1765
0.1333
0.2
0.1429
0.1111
0.125
0.1
0.1
0.1667
0.1667
0.1
0.1818
0.125
0.2308
0.1667
0.1667
0.1
0.1923
0.2727
0.3913
0.1429
0.1316
0.1
0.1429
0.12
0.1818
0.1
0.1
0.1429
0.1471
0.1818
0.2727
0.2143
0.1667
0.3
0.1
0.1
0.3077
0.1
0.1818
0.125
0.1
0.2
0.1333
0.25
0.1
0.2
0.1
0.1
0.1429
0.1
0.1053
0.6
0.7692
0.6923
0.5

4
6
4
7
3
3
3
2
2
3
3
2
3
5
2
9
3
3
4
3
2
2
3
2
3
3
4
2
2
3
4
12
13
2
5
3
7
2
2
4
4
4
2
5
8
2
2
2
3
3
2
6
6
5
2
6
2
14
11
4
2
5
2
5
3
4
2
2
2
2
7
2
4
4
4
4
2
3
3
2
2
2
3
6
3
2
3
2
2
10
3
4
4
3
3
11

2
6
3
4
2
2
2
2
2
2
2
2
2
3
2
4
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
7
4
2
2
2
3
2
2
2
2
4
2
2
3
2
2
2
2
2
2
4
3
2
2
2
2
6
4
4
2
2
2
2
2
2
2
2
2
2
3
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
4
3
2
10

[10,10]
[10,30]
[11,15]
[10,19]
[12,18]
[10,10]
[10,11]
[10,17]
[10,12]
[12,42]
[10,14]
[33,34]
[17,28]
[13,17]
[10,16]
[10,29]
[16,20]
[10,12]
[10,19]
[10,10]
[10,10]
[10,10]
[10,19]
[14,15]
[17,19]
[17,18]
[20,25]
[10,10]
[10,10]
[10,10]
[10,15]
[12,36]
[14,37]
[10,10]
[11,14]
[10,10]
[18,30]
[10,20]
[10,10]
[20,30]
[17,141]
[15,27]
[10,10]
[14,29]
[20,80]
[16,17]
[10,10]
[10,10]
[12,17]
[10,12]
[10,10]
[11,20]
[10,17]
[13,18]
[10,12]
[12,25]
[10,10]
[26,72]
[11,20]
[10,25]
[10,21]
[10,39]
[10,10]
[14,19]
[20,26]
[10,11]
[10,10]
[10,11]
[16,29]
[34,49]
[41,44]
[12,49]
[10,14]
[12,12]
[10,12]
[10,10]
[10,10]
[10,13]
[10,10]
[10,11]
[16,17]
[10,10]
[10,10]
[10,15]
[10,12]
[10,10]
[10,10]
[10,10]
[10,10]
[18,21]
[10,10]
[10,19]
[10,18]
[10,13]
[12,13]
[10,26]

TableS10

chr11:73430852
chr2:219745270
chr2:101252599
chr2:75745337
chr2:70293015
chr2:70293359
chr2:20864698
chr2:24105961
chr2:24107295
chr2:200532846
chr2:37332800
chr2:98583502
chr2:200498968
chr2:73309181
chr2:73309135
chr2:73310761
chr2:73308708
chr2:24866665
chr2:24866667
chr2:24866668
chr2:233430567
chr2:63687807
chr2:63687808
chr3:10143590
chr3:10143624
chr3:114207233
chr3:114206623
chr3:114206798
chr3:14684643
chr3:10108922
chr3:10118022
chr3:11824319
chr3:130492301
chr3:130506708
chr3:88288196
chr3:113322488
chr3:113323430
chr3:56655601
chr3:56647814
chr3:56632354
chr4:129169344
chr4:129169342
chr4:17415360
chr4:17415248
chr4:17415068
chr4:17415043
chr4:17411751
chr4:39229326
chr4:39229793
chr4:39316754
chr4:159809850
chr4:159810121
chr4:2662454
chr4:2631571
chr4:2704016
chr5:111119386
chr5:31570171
chr5:31589572
chr5:31590201
chr5:31590202
chr5:134218703
chr5:131839529
chr6:34663647
chr6:139406076
chr6:30727033
chr6:30726838
chr6:30725677
chr6:43101767
chr6:43105289
chr6:151832250
chr6:151832397
chr6:44080470
chr6:31910687
chr6:24813294
chr6:24813931
chr6:169897394
chr6:169898770
chr6:149954290
chr6:36999393
chr6:37000057
chr7:40139345
chr7:40140726
chr7:6608296
chr7:2544772
chr7:66053507
chr7:66058377
chr7:66060614
chr7:66060623
chr7:99592197
chr7:1003168
chr7:99585055
chr7:99589763
chr7:99590628
chr7:99590979
chr7:99589755
chr7:99589759

C2CD3
C2orf24
C2orf29
C2orf3
C2orf42
C2orf42
C2orf43
C2orf44
C2orf44
C2orf47
C2orf56
C2orf64
C2orf69
C2orf7
C2orf7
C2orf7
C2orf7
C2orf79
C2orf79
C2orf79
C2orf82
C2orf86
C2orf86
C3orf10
C3orf10
C3orf17
C3orf17
C3orf17
C3orf19
C3orf24
C3orf24
C3orf31
C3orf37
C3orf37
C3orf38
C3orf52
C3orf52
C3orf63
C3orf63
C3orf63
C4orf29
C4orf29
C4orf30
C4orf30
C4orf30
C4orf30
C4orf30
C4orf34
C4orf34
C4orf34
C4orf46
C4orf46
C4orf8
C4orf8
C4orf8
C5orf13
C5orf22
C5orf22
C5orf22
C5orf22
C5orf24
C5orf56
C6orf106
C6orf115
C6orf136
C6orf136
C6orf136
C6orf153
C6orf153
C6orf211
C6orf211
C6orf223
C6orf48
C6orf62
C6orf62
C6orf70
C6orf70
C6orf72
C6orf89
C6orf89
C7orf11
C7orf11
C7orf26
C7orf27
C7orf42
C7orf42
C7orf42
C7orf42
C7orf43
C7orf50
C7orf59
C7orf59
C7orf59
C7orf59
C7orf59
C7orf59

mixed
UTR3
UTR3
coding_exon
mixed
mixed
mixed
UTR3
UTR3
coding_exon
mixed
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
mixed
mixed
mixed
mixed
mixed
coding_exon
UTR3
UTR3
coding_exon
mixed
mixed
coding_exon
coding_exon
UTR3
mixed
mixed
mixed
coding_exon
coding_exon
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
coding_exon
coding_exon
UTR3
mixed
mixed
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
mixed
UTR5
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR5
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
mixed
mixed
mixed
UTR3
UTR3

ENST00000321027:HtoR;ENST00000409857:HtoR;

ENST00000295079:KtoR;ENST00000392290:KtoR;

ENST00000258083:HtoP;

ENST00000314400:VtoD;ENST00000383675:VtoD;ENST00000393857:VtoD;ENST00

ENST00000444133:ItoL;ENST00000455809:ItoL;

ENST00000296313:HtoR;ENST00000355628:HtoR;ENST00000431842:HtoR;ENST00

ENST00000388795:PtoT;ENST00000398961:PtoT;ENST00000398965:PtoT;ENST000
ENST00000388795:NtoS;ENST00000398961:NtoS;ENST00000398965:NtoS;ENST000
ENST00000382247:VtoI;
ENST00000382247:KtoM;
ENST00000382247:FtoY;

ENST00000324666:NtoT;ENST00000382839:NtoT;

ENST00000435259:ItoV;

ENST00000293604:WtoS;ENST00000376471:WtoS;ENST00000376473:WtoS;
ENST00000293604:KtoR;ENST00000376471:KtoR;ENST00000376473:KtoR;
ENST00000293604:EtoK;ENST00000376473:EtoK;

ENST00000366772:QtoR;ENST00000366773:QtoR;
ENST00000366772:FtoI;ENST00000366773:FtoI;

ENST00000344417:NtoS;ENST00000359073:NtoS;
ENST00000341567:Gto*;

ENST00000316937:YtoH;ENST00000419841:YtoH;ENST00000457641:YtoH;

56

+
+

+
+

+
+
+
+
+

+
+

+
+
+

+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+

+
+
+
+
+

+
+
+
+

+
+
+
+
+
+

GtoA
TtoG
TtoA
AtoG
AtoG
AtoG
TtoA
AtoG
TtoC
AtoG
AtoG
TtoA
GtoA
AtoC
CtoT
TtoC
TtoC
GtoC
AtoG
CtoG
TtoC
TtoC
AtoT
TtoC
TtoC
TtoA
TtoG
TtoC
AtoG
TtoC
AtoT
AtoC
AtoG
CtoA
TtoC
TtoC
AtoG
AtoG
AtoG
AtoT
CtoA
AtoG
GtoA
AtoT
TtoA
AtoG
GtoA
TtoC
TtoC
GtoT
GtoA
TtoC
AtoC
AtoG
TtoC
AtoG
GtoA
GtoA
GtoC
AtoT
AtoG
TtoA
AtoG
TtoA
GtoC
AtoG
GtoA
TtoC
AtoG
CtoA
AtoG
AtoG
GtoT
GtoT
TtoC
AtoG
TtoA
TtoA
TtoA
TtoA
TtoA
AtoT
AtoG
AtoG
GtoT
TtoC
AtoG
TtoC
TtoC
AtoG
TtoA
GtoA
GtoT
GtoT
GtoA
TtoC

0.1667
0.1176
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1333
0.1
0.1
0.1
0.1818
0.2
0.1818
0.1176
0.1538
0.1053
0.1111
0.1111
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1429
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1111
0.1667
0.1
0.1667
0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1111
0.1
0.1
0.1
0.1
0.1667
0.1364
0.1176
0.1
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.125
0.6154
0.1176
0.1154
0.1
0.1429
0.1
0.1429
0.1
0.5455
0.1
0.1
0.1111
0.1

0.1667
0.1176
0.1
0.1538
0.1
0.1111
0.1
0.1176
0.1
0.1667
0.1
0.1
0.1
0.2
0.3636
0.4
0.2857
0.1667
0.1667
0.12
0.2143
0.2857
0.2
0.1176
0.1111
0.5
0.1429
0.1538
0.1818
0.1
0.1
0.2
0.125
0.12
0.1053
0.2
0.1875
0.1
0.1053
0.125
0.2
0.1
0.1429
0.5
0.3
0.2
0.2143
0.125
0.2
0.2941
0.125
0.125
0.2
0.1
0.25
0.1176
0.1
0.1
0.1
0.1818
0.1
0.1333
0.1977
0.1333
0.1
0.1538
0.1667
0.1818
0.1
0.2
0.2727
0.3
0.1333
0.2353
0.1429
0.1
0.1176
0.1818
0.1
0.1333
0.1053
0.1
0.1818
1
0.1429
0.125
0.125
0.1667
0.1111
0.2
0.1
0.6667
0.1
0.125
0.1515
0.1154

4
5
4
2
3
2
3
2
2
3
3
6
2
7
5
10
6
3
10
4
5
14
10
7
2
3
4
4
4
4
5
4
2
4
4
2
7
3
3
2
2
2
5
5
6
4
4
3
3
8
5
2
3
3
4
8
2
2
3
4
2
6
3
4
3
3
2
4
3
2
3
3
5
5
4
4
2
4
2
6
5
3
5
5
2
10
2
3
2
5
4
2
2
4
4
8

2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
4
4
2
5
2
2
11
7
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
4
3
4
4
3
2
2
3
2
2
2
2
2
2
2
2
2
3
2
2
3
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
5
2
3
2
3
2
3
2
2
2
2
2
2

[12,12]
[17,18]
[10,20]
[10,13]
[10,10]
[18,19]
[10,10]
[10,17]
[10,10]
[12,15]
[10,11]
[10,30]
[10,10]
[11,15]
[11,15]
[10,16]
[12,17]
[12,13]
[14,21]
[18,25]
[14,18]
[10,37]
[10,27]
[18,34]
[10,10]
[10,16]
[14,20]
[11,13]
[10,11]
[10,10]
[10,11]
[10,10]
[16,19]
[10,25]
[19,20]
[10,10]
[10,18]
[10,10]
[10,19]
[10,16]
[10,10]
[10,10]
[10,19]
[10,14]
[10,19]
[10,20]
[10,14]
[10,24]
[19,20]
[10,19]
[10,16]
[16,18]
[10,12]
[10,10]
[12,16]
[17,17]
[10,10]
[10,10]
[10,10]
[10,11]
[10,10]
[10,15]
[40,86]
[10,15]
[10,10]
[13,18]
[10,12]
[10,11]
[10,11]
[10,10]
[11,12]
[10,22]
[15,17]
[15,20]
[16,22]
[10,10]
[10,17]
[10,11]
[10,10]
[10,15]
[10,19]
[10,10]
[11,16]
[13,17]
[17,28]
[27,33]
[16,20]
[12,14]
[10,10]
[10,28]
[10,10]
[12,12]
[10,10]
[10,16]
[18,33]
[20,26]

TableS10

chr7:99589762
chr7:112247007
chr8:146250517
chr8:33477873
chr8:143814372
chr8:143814660
chr8:86314079
chr8:86314009
chr8:86319843
chr8:124301619
chr8:124312866
chr9:35653375
chr9:97677149
chr9:129966018
chr9:5351155
chr9:5351851
chr9:5348207
chr9:85744131
chr9:4654902
chr9:131629503
chr9:114491698
chr9:114491681
chr9:26877510
chr9:76873811
chr22:22813431
chr12:1972777
chr1:179814950
chr1:180035390
chr2:27297602
chr17:44296134
chr10:105196589
chr10:105199708
chr2:47253101
chr2:47156201
chr2:47240893
chr2:47257139
chr2:47257140
chr2:47257146
chr19:12915900
chr19:12916269
chr19:12916273
chr7:128198292
chr7:128198548
chr7:128198672
chr10:12907702
chr10:12851714
chr10:12912013
chr10:12916593
chr4:114593599
chr10:75242710
chr5:110847856
chr5:110848173
chr5:110848176
chr12:120162590
chr5:134105060
chr9:137854457
chr1:199096371
chr12:65990255
chr12:65993007
chr3:12852538
chr3:12852539
chr3:12852540
chr3:12852544
chr3:12852545
chr3:12852547
chr17:74500590
chr5:179088514
chr5:179090533
chr2:85475400
chr11:64736039
chr2:241183391
chr2:241183392
chr15:40431558
chr19:41333090
chr11:34078429
chr11:34079232
chr1:113011240
chr1:113003871
chr7:116346164
chr7:116346167
chr7:116346357
chr1:19537975
chr1:19537977
chr19:53444845
chr16:8854697
chr16:8854698
chr16:8856270
chr13:110087477
chr13:110085827
chr11:2995734
chr13:110091770
chr17:35578166
chr17:35580292
chr15:38701703
chr15:38705127
chr11:104417540

C7orf59
C7orf60
C8orf33
C8orf41
C8orf55
C8orf55
C8orf59
C8orf59
C8orf59
C8orf76
C8orf76
C9orf100
C9orf130
C9orf16
C9orf46
C9orf46
C9orf46
C9orf64
C9orf68
C9orf78
C9orf80
C9orf80
C9orf82
C9orf95
CABIN1
CACNA1C
CACNA1E
CACNA1E
CAD
CALCOCO2
CALHM2
CALHM2
CALM2
CALM2
CALM2
CALM2
CALM2
CALM2
CALR
CALR
CALR
CALU
CALU
CALU
CAMK1D
CAMK1D
CAMK1D
CAMK1D
CAMK2D
CAMK2G
CAMK4
CAMK4
CAMK4
CAMKK2
CAMLG
CAMSAP1
CAMSAP1L1
CAND1
CAND1
CAND2
CAND2
CAND2
CAND2
CAND2
CAND2
CANT1
CANX
CANX
CAPG
CAPN1
CAPN10
CAPN10
CAPN3
CAPNS1
CAPRIN1
CAPRIN1
CAPZA1
CAPZA1
CAPZA2
CAPZA2
CAPZA2
CAPZB
CAPZB
CARD8
CARHSP1
CARHSP1
CARHSP1
CARKD
CARKD
CARS
CARS2
CASC3
CASC3
CASC5
CASC5
CASP1

UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR5
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR5
mixed
UTR3
UTR3
UTR5
UTR5
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR5
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
UTR3
coding_exon
mixed
coding_exon
UTR3
coding_exon
mixed
coding_exon
coding_exon
coding_exon

ENST00000417663:DtoN;ENST00000421308:DtoN;ENST00000431163:DtoN;ENST00

ENST00000276704:StoP;
ENST00000276704:StoA;
ENST00000343259:VtoA;ENST00000378382:VtoA;ENST00000378387:VtoA;ENST00

ENST00000223864:VtoA;
ENST00000223864:EtoG;

ENST00000374236:StoC;ENST00000374242:StoC;
ENST00000374236:RtoW;ENST00000374242:RtoW;
ENST00000333916:EtoG;
ENST00000263119:LtoP;ENST00000398319:LtoP;ENST00000405822:LtoP;
ENST00000357570:KtoE;ENST00000358338:KtoE;ENST00000360108:KtoE;ENST000
ENST00000264705:StoP;ENST00000403525:StoP;

ENST00000378845:YtoS;
ENST00000378845:StoP;ENST00000378847:StoP;

ENST00000297156:VtoA;
ENST00000312405:VtoE;ENST00000389532:VtoE;ENST00000389533:VtoE;ENST000

ENST00000354082:Wto*;ENST00000391982:Wto*;ENST00000391984:Wto*;ENST0
ENST00000354082:KtoQ;ENST00000391982:KtoQ;ENST00000391984:KtoQ;ENST00

ENST00000263168:NtoD;
ENST00000263168:KtoE;

ENST00000309957:VtoG;ENST00000397191:VtoG;ENST00000424185:VtoG;ENST00

ENST00000260369:PtoH;ENST00000346991:PtoH;ENST00000399668:PtoH;

57

+
+

+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+

+
+
+

+
+
+
+
+
+
+
+
+

+
+

+
+
+
+
+
+
+
+
+
+
+
+

+
+

+
+
+
+

AtoG
TtoC
AtoG
AtoT
GtoT
TtoC
GtoA
TtoA
CtoT
TtoC
TtoG
TtoC
CtoA
TtoC
TtoC
AtoG
AtoG
AtoG
AtoT
GtoA
CtoG
CtoT
AtoG
TtoC
TtoC
AtoG
AtoG
TtoG
TtoC
AtoG
CtoA
AtoC
TtoC
GtoT
TtoA
AtoT
GtoC
TtoG
GtoC
AtoG
AtoG
TtoA
AtoG
TtoG
AtoC
TtoC
TtoG
TtoG
GtoA
AtoG
TtoC
TtoC
AtoG
AtoG
TtoC
TtoA
TtoC
AtoG
AtoG
AtoT
TtoC
GtoT
GtoT
AtoT
GtoT
TtoG
TtoC
TtoA
GtoA
CtoA
GtoA
AtoC
AtoC
TtoA
TtoC
GtoA
AtoG
AtoG
TtoC
TtoA
TtoC
TtoG
GtoA
AtoG
TtoC
CtoT
GtoA
TtoG
TtoA
CtoT
AtoG
AtoC
AtoG
CtoA
GtoA
TtoC

0.1
0.1
0.1
0.1
0.1
0.1
0.1667
0.2
0.1034
0.1
0.1
0.1
0.1
0.1111
0.1
0.1538
0.1
0.1
0.1
0.1875
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1053
0.1
0.1
0.1
0.1
0.1
0.1224
0.1
0.1026
0.1
0.1364
0.1154
0.1818
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1071
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1667
0.1034
0.1084
0.1364
0.1048
0.1086
0.1117
0.1
0.1667
0.1333
0.1538
0.1176
0.1
0.125
0.1
0.4615
0.1
0.1
0.119
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1429
0.1818
0.1818
0.1818
0.1875
0.1
0.1034
0.1
0.1
0.1
0.1

0.125
0.1
0.1
0.1111
0.1
0.1
0.4286
0.3077
0.125
0.1
0.1
0.1667
0.1
0.1818
0.1
0.2
0.1765
0.1
0.1333
0.25
0.1538
0.125
0.1429
0.1667
0.1
0.1
0.1
0.1429
0.1111
0.1333
0.2727
0.2667
0.1111
0.125
0.125
0.2222
0.1304
0.1667
0.1579
0.1667
0.25
0.125
0.1538
0.1
0.125
0.1
0.1
0.2353
0.1
0.1
0.2
0.1111
0.1667
0.125
0.1538
0.1
0.125
0.1538
0.3571
0.2
0.1333
0.1429
0.177
0.2373
0.2025
0.1538
0.2
0.3
0.2
0.1818
0.1818
0.1429
0.1538
0.6667
0.1212
0.1429
0.1923
0.1
0.2857
0.1
0.2222
0.1154
0.1667
0.2
0.1667
0.5455
0.6364
0.2
0.1875
0.2857
0.2
0.1667
0.1
0.1
0.1333
0.1538

4
2
2
4
2
2
2
2
5
5
2
3
2
7
3
4
2
2
2
5
5
2
3
3
2
2
4
4
6
6
2
4
2
6
8
8
4
9
3
12
3
5
4
2
2
4
2
2
2
3
3
4
12
4
3
2
2
3
2
5
11
9
15
19
19
3
4
9
2
2
3
4
5
3
2
2
12
5
3
3
2
3
4
4
2
6
10
3
6
5
4
3
2
2
2
9

2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
4
2
3
2
4
3
3
2
3
2
3
3
2
2
2
2
2
2
3
2
2
6
2
2
2
2
2
2
4
4
2
5
11
15
3
2
8
2
2
2
2
2
3
2
2
2
2
3
2
2
2
2
2
2
6
8
2
2
2
4
2
2
2
2
2

[10,17]
[10,10]
[10,20]
[11,19]
[10,10]
[10,11]
[14,24]
[11,13]
[16,29]
[10,10]
[10,10]
[10,18]
[10,10]
[11,18]
[11,20]
[10,13]
[10,17]
[10,10]
[10,15]
[12,16]
[13,19]
[16,20]
[10,14]
[10,12]
[10,10]
[10,11]
[10,10]
[14,18]
[19,27]
[10,15]
[10,12]
[10,29]
[10,10]
[10,24]
[34,54]
[10,55]
[18,39]
[10,14]
[22,38]
[12,27]
[11,12]
[10,24]
[10,13]
[10,10]
[10,16]
[10,10]
[10,10]
[10,18]
[10,10]
[10,20]
[10,28]
[10,18]
[10,12]
[16,19]
[10,13]
[10,10]
[10,16]
[13,20]
[12,15]
[10,29]
[15,83]
[21,22]
[35,114]
[38,178]
[63,569]
[10,17]
[10,18]
[15,40]
[10,14]
[11,17]
[10,11]
[14,16]
[10,13]
[10,13]
[41,66]
[14,20]
[26,42]
[10,20]
[10,14]
[10,10]
[10,10]
[11,28]
[12,17]
[10,10]
[10,18]
[10,21]
[11,22]
[10,11]
[12,17]
[14,16]
[10,13]
[18,29]
[10,10]
[10,11]
[10,15]
[10,13]

TableS10

chr7:142713204
chr4:185786290
chr4:185787180
chr4:185787401
chr11:104318849
chr2:201839549
chr5:96134289
chr5:96134648
chr5:96135536
chr11:34449665
chr20:31696261
chr16:87470044
chr16:65690393
chr16:65691715
chr16:65692254
chr11:118679382
chr11:118680246
chr11:118682349
chr11:118682601
chr11:118683108
chr3:106903631
chr3:106859864
chr4:170146290
chr12:52932236
chr12:52914322
chr12:52914708
chr12:52915110
chr12:52916820
chr12:52921522
chr22:37589492
chr22:37394057
chr22:37399621
chr19:13891753
chr1:52599263
chr10:70183734
chr10:70184565
chr10:70172216
chr10:70178933
chr2:55616394
chr9:35651157
chr4:110825222
chr4:110828218
chr22:27514201
chr22:27514937
chr22:27515169
chr19:17915788
chr3:125150669
chr5:42837433
chr6:139156081
chr1:32443562
chr1:32443563
chr11:27318833
chr3:181810445
chr3:181810670
chr17:59959434
chr17:59957532
chr17:59177086
chr17:34211928
chr17:34224805
chr17:34220359
chr17:34219544
chr17:34220249
chr17:34211814
chr3:114655226
chr12:100979186
chr17:25469263
chr17:25523691
chr17:77652659
chr3:123569761
chr3:123561421
chr12:81270955
chr19:51201700
chr5:150542231
chr3:49175343
chr2:37176091
chr2:37170500
chr1:100386333
chr11:95756933
chr11:118390957
chr2:55376418
chr11:63873710
chr11:63873713
chr11:63881574
chr14:90874160
chr14:90819614
chr19:52455435
chr11:82650574
chr12:28435532
chr19:46520849
chr5:168953818
chr6:31230419
chr16:55957595
chr16:55950195
chr4:122958228
chr5:68509235
chr5:68498741

CASP2
CASP3
CASP3
CASP3
CASP4
CASP8
CAST
CAST
CAST
CAT
CBFA2T2
CBFA2T3
CBFB
CBFB
CBFB
CBL
CBL
CBL
CBL
CBL
CBLB
CBLB
CBR4
CBX5
CBX5
CBX5
CBX5
CBX5
CBX5
CBX6
CBY1
CBY1
CC2D1A
CC2D1B
CCAR1
CCAR1
CCAR1
CCAR1
CCDC104
CCDC107
CCDC109B
CCDC109B
CCDC117
CCDC117
CCDC117
CCDC124
CCDC14
CCDC152
CCDC28A
CCDC28B
CCDC28B
CCDC34
CCDC39
CCDC39
CCDC45
CCDC45
CCDC47
CCDC49
CCDC49
CCDC49
CCDC49
CCDC49
CCDC49
CCDC52
CCDC53
CCDC55
CCDC55
CCDC57
CCDC58
CCDC58
CCDC59
CCDC61
CCDC69
CCDC71
CCDC75
CCDC75
CCDC76
CCDC82
CCDC84
CCDC88A
CCDC88B
CCDC88B
CCDC88B
CCDC88C
CCDC88C
CCDC9
CCDC90B
CCDC91
CCDC97
CCDC99
CCHCR1
CCL22
CCL22
CCNA2
CCNB1
CCNB1

UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
coding_exon
mixed
UTR3
UTR5
UTR3
UTR3
UTR5

ENST00000264274:QtoR;ENST00000264275:QtoR;ENST00000303385:QtoR;ENST00

ENST00000216029:StoP;ENST00000396811:StoP;ENST00000454616:StoP;
ENST00000318003:VtoL;ENST00000397486:VtoL;ENST00000412841:VtoL;
ENST00000265872:LtoP;
ENST00000265872:FtoS;

ENST00000344132:FtoI;ENST00000394650:FtoI;

ENST00000328697:NtoS;

ENST00000269064:HtoL;ENST00000397727:HtoL;

ENST00000225428:NtoK;
ENST00000225428:LtoR;
ENST00000225428:EtoK;

ENST00000295872:StoI;

ENST00000291458:NtoK;ENST00000479899:NtoK;

ENST00000263284:LtoP;

ENST00000281932:EtoG;ENST00000379187:EtoG;ENST00000409774:EtoG;

ENST00000389857:EtoG;
ENST00000331194:StoT;ENST00000389857:GtoA;ENST00000427583:StoT;

ENST00000306172:QtoR;ENST00000381259:QtoR;
ENST00000265295:LtoP;ENST00000446362:LtoP;

58

+
+
+
+
+
+

+
+
+
+
+
+
+
+

+
+
+

+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+

+
+

+
+

+
+
+

+
+
+

+
+
+

+
+

+
+

TtoC
AtoG
AtoG
GtoT
TtoG
AtoG
TtoA
TtoA
AtoG
TtoA
AtoC
AtoG
TtoA
GtoA
TtoG
TtoC
TtoC
TtoG
GtoC
TtoC
TtoA
AtoC
TtoC
TtoA
GtoA
AtoG
AtoG
GtoT
CtoA
GtoA
TtoC
TtoA
GtoC
GtoA
TtoC
TtoC
AtoT
AtoC
GtoA
TtoC
TtoA
TtoC
GtoC
TtoC
AtoG
TtoC
CtoG
AtoG
AtoG
CtoA
AtoG
AtoG
AtoC
TtoC
AtoT
AtoG
TtoG
TtoA
TtoG
GtoA
AtoG
GtoA
TtoA
GtoT
CtoT
CtoT
TtoC
AtoG
TtoG
TtoC
AtoG
TtoC
TtoC
TtoG
AtoG
AtoG
AtoG
TtoC
TtoC
AtoT
GtoC
CtoG
GtoA
AtoG
GtoC
TtoC
TtoG
AtoG
TtoC
TtoC
GtoT
TtoG
TtoG
CtoG
TtoG
GtoT

0.1
0.1111
0.1176
0.1
0.1053
0.1
0.1
0.1
0.125
0.1
0.1
0.1
0.1
0.1
0.12
0.1
0.125
0.5455
0.1
0.1176
0.1
0.1
0.1
0.1053
0.1579
0.1304
0.1
0.1
0.1
0.1818
0.1
0.1
0.1
0.1
0.1
0.1111
0.125
0.1
0.1429
0.1
0.1111
0.1053
0.1111
0.1
0.1429
0.1071
0.1538
0.1
0.1
0.1333
0.129
0.4211
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1163
0.1
0.1667
0.1
0.1
0.2308
0.1
0.1111
0.1053
0.1176
0.1
0.1
0.1304
0.1053
0.1
0.1538
0.1
0.1
0.1818
0.1
0.1111
0.1
0.1538
0.1
0.1
0.1
0.1
0.1667
0.12
0.1
0.1
0.1154
0.4167
0.1
0.1538
0.1

0.1
0.2
0.1333
0.1091
0.1111
0.1429
0.1818
0.1
0.1538
0.1111
0.2
0.1818
0.2
0.1
0.1818
0.1333
0.1429
0.5769
0.1333
0.12
0.1
0.1429
0.1
0.12
0.1667
0.1538
0.1176
0.15
0.1
0.2143
0.1429
0.1
0.2
0.1
0.1
0.2
0.1333
0.1765
0.1818
0.1538
0.1579
0.2
0.1818
0.2
0.1818
0.1875
0.2
0.1429
0.2
0.3333
0.2632
0.4615
0.1
0.1
0.1
0.1
0.3077
0.1667
0.1
0.3
0.2143
0.1667
0.1818
0.1
0.1429
0.3
0.2727
0.1739
0.125
0.1739
0.1
0.1
0.15
0.1111
0.1
0.1765
0.1
0.1538
0.1818
0.1053
0.12
0.2
0.2
0.1
0.1053
0.125
0.1176
0.25
0.2
0.1053
0.1
0.1667
0.4706
0.1
0.1538
0.2

4
7
7
5
6
3
4
5
2
6
2
3
3
5
7
3
4
2
2
6
3
2
2
3
2
3
4
4
2
2
2
4
2
2
2
2
2
5
4
13
5
4
2
4
3
5
2
2
3
7
8
2
3
3
2
2
4
5
2
5
16
3
2
2
3
3
3
3
3
6
2
2
3
5
2
3
2
4
4
4
2
5
2
2
3
4
4
2
3
2
2
6
3
3
9
3

2
3
2
3
2
2
2
2
2
2
2
2
2
2
4
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
3
5
2
3
2
2
2
2
2
2
2
6
5
2
2
2
2
2
2
3
2
3
7
2
2
2
2
2
3
2
2
4
2
2
2
2
2
2
2
2
2
2
2
4
2
2
2
2
2
2
2
2
2
2
3
2
2
2

[10,10]
[10,18]
[15,17]
[20,55]
[10,19]
[10,14]
[10,11]
[10,20]
[13,16]
[10,18]
[10,10]
[10,11]
[10,10]
[10,10]
[11,26]
[10,15]
[14,16]
[12,26]
[15,20]
[17,25]
[10,20]
[10,14]
[10,10]
[19,25]
[12,19]
[13,24]
[10,17]
[20,20]
[10,10]
[14,22]
[10,14]
[10,20]
[10,10]
[10,10]
[10,10]
[10,18]
[15,16]
[10,17]
[11,14]
[10,26]
[21,37]
[10,19]
[10,11]
[10,10]
[11,21]
[16,28]
[10,13]
[15,20]
[10,10]
[12,31]
[12,31]
[13,19]
[10,10]
[10,10]
[10,10]
[10,10]
[10,13]
[10,13]
[10,11]
[10,22]
[14,43]
[10,12]
[11,12]
[10,10]
[10,14]
[10,39]
[10,33]
[18,23]
[16,19]
[15,24]
[10,10]
[10,10]
[20,23]
[19,28]
[10,10]
[13,17]
[10,10]
[10,13]
[11,11]
[10,19]
[25,27]
[10,26]
[11,27]
[10,10]
[10,19]
[10,24]
[10,17]
[12,12]
[10,25]
[10,21]
[10,10]
[12,28]
[12,21]
[10,10]
[13,26]
[10,10]

TableS10

chr14:19854432
chr6:100097483
chr6:100097586
chr12:4280763
chr12:4280794
chr12:4281331
chr12:4253196
chr12:4253215
chr6:42011333
chr19:35003512
chr19:35006474
chr19:35006559
chr16:2447710
chr16:2448852
chr5:86740926
chr4:78187338
chr4:78187806
chr4:78187808
chr3:158352661
chr3:158350635
chr2:135428250
chr10:35845544
chr17:35963548
chr17:35963549
chr12:68265515
chr1:154545404
chr2:61949130
chr2:73333617
chr6:109794440
chr6:109794639
chr6:109794640
chr6:109794648
chr6:109794650
chr3:113551306
chr3:113542498
chr19:40514815
chr19:40515294
chr19:40530094
chr18:65765238
chr18:65679662
chr18:65679663
chr18:65681167
chr18:65681396
chr18:65681589
chr12:6431137
chr12:6431138
chr12:6431141
chr9:5460448
chr6:47700552
chr6:47701927
chr6:47702068
chr17:69981559
chr19:50603835
chr11:35208047
chr11:35209485
chr11:35209595
chr1:206007030
chr1:206033566
chr1:206033847
chr1:206035103
chr3:109245583
chr3:109245728
chr1:26519601
chr1:111244030
chr1:111217296
chr1:111217298
chr1:116862939
chr12:9796567
chr19:6536894
chr5:149761401
chr5:149761402
chr5:149761403
chr5:149761406
chr5:149761408
chr5:149761980
chr5:149772511
chr5:149772524
chr19:47077273
chr17:59359836
chr3:123321130
chr15:40803736
chr10:12278284
chr10:62217991
chr1:43601439
chr3:48173786
chr20:3731597
chr20:3726278
chr20:3733821
chr5:137649188
chr9:115060817
chr17:42574390
chr17:42550711
chr1:1637753
chr1:1640667
chr7:40094317
chr7:40100653

CCNB1IP1
CCNC
CCNC
CCND2
CCND2
CCND2
CCND2
CCND2
CCND3
CCNE1
CCNE1
CCNE1
CCNF
CCNF
CCNH
CCNI
CCNI
CCNI
CCNL1
CCNL1
CCNT2
CCNY
CCR7
CCR7
CCT2
CCT3
CCT4
CCT7
CD164
CD164
CD164
CD164
CD164
CD200
CD200
CD22
CD22
CD22
CD226
CD226
CD226
CD226
CD226
CD226
CD27
CD27
CD27
CD274
CD2AP
CD2AP
CD2AP
CD300A
CD3EAP
CD44
CD44
CD44
CD46
CD46
CD46
CD46
CD47
CD47
CD52
CD53
CD53
CD53
CD58
CD69
CD70
CD74
CD74
CD74
CD74
CD74
CD74
CD74
CD74
CD79A
CD79B
CD86
CDAN1
CDC123
CDC2
CDC20
CDC25A
CDC25B
CDC25B
CDC25B
CDC25C
CDC26
CDC27
CDC27
CDC2L2
CDC2L2
CDC2L5
CDC2L5

coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR5
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR5
mixed
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR5
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
mixed
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon

ENST00000353689:ItoV;ENST00000358932:ItoV;ENST00000398160:ItoV;ENST0000

ENST00000262643:YtoH;ENST00000444983:YtoH;
ENST00000262643:TtoP;ENST00000357943:TtoP;ENST00000444983:TtoP;

ENST00000256897:CtoF;ENST00000448765:CtoF;

ENST00000295926:WtoR;ENST00000417607:WtoR;ENST00000461804:WtoR;

ENST00000265375:YtoD;ENST00000339497:YtoD;ENST00000374704:YtoD;ENST000

ENST00000315711:VtoA;ENST00000383681:VtoA;ENST00000451093:VtoA;ENST00
ENST00000085219:LtoR;ENST00000341773:LtoR;ENST00000419549:LtoR;

ENST00000280200:NtoD;

ENST00000309424:KtoE;ENST00000423698:KtoE;

ENST00000281141:StoP;ENST00000378900:StoP;
ENST00000307250:HtoQ;ENST00000373811:HtoQ;ENST00000395284:HtoQ;ENST0

ENST00000245960:LtoP;ENST00000340833:LtoP;ENST00000344256:LtoP;ENST0000

ENST00000066544:EtoA;ENST00000441612:EtoA;
ENST00000317673:RtoK;ENST00000341028:RtoK;ENST00000341832:RtoK;ENST000
ENST00000181839:MtoV;ENST00000340829:MtoV;
ENST00000181839:LtoP;ENST00000340829:LtoP;

59

+
+
+
+
+

+
+
+
+
+

+
+

+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+

+
+
+

+
+
+

+
+

AtoG
TtoC
GtoT
AtoG
AtoT
AtoG
AtoG
AtoT
AtoC
TtoC
AtoC
GtoA
TtoC
TtoC
GtoT
TtoC
AtoG
TtoA
TtoA
TtoC
TtoG
TtoG
AtoG
AtoG
GtoA
TtoC
TtoC
TtoG
TtoA
GtoT
GtoC
TtoA
AtoG
TtoC
AtoT
TtoG
AtoG
AtoG
AtoG
AtoT
TtoC
AtoG
GtoA
AtoG
CtoA
AtoG
CtoA
TtoC
AtoG
TtoC
AtoG
CtoT
AtoG
TtoC
AtoC
GtoA
AtoG
TtoC
AtoG
TtoA
TtoC
AtoC
AtoG
TtoA
AtoC
TtoC
TtoA
AtoG
AtoG
AtoG
AtoG
TtoA
TtoA
GtoA
TtoG
TtoG
CtoT
AtoG
AtoG
TtoC
TtoC
TtoC
TtoA
TtoC
TtoA
TtoC
AtoG
AtoG
AtoG
TtoC
AtoC
TtoC
GtoA
GtoA
AtoG
TtoC

0.1
0.1
0.1
0.102
0.1176
0.1333
0.1
0.1515
0.2222
0.1
0.1111
0.1053
0.1154
0.1667
0.2
0.1429
0.1
0.1429
0.1176
0.102
0.1
0.1
0.1
0.2143
0.1
0.1
0.1
0.1029
0.1
0.1
0.1
0.1
0.1304
0.1053
0.1
0.1
0.1111
0.1538
0.1
0.1053
0.1
0.1071
0.1
0.1
0.1
0.1
0.2
0.1111
0.1
0.1
0.1
0.1
0.1
0.1538
0.1034
0.1071
0.1
0.1053
0.1
0.1111
0.125
0.1
0.1724
0.1053
0.1
0.1429
0.1
0.1429
0.1
0.1
0.1364
0.1933
0.1538
0.1402
0.1222
0.1515
0.1053
0.1
0.2105
0.1
0.1
0.1
0.1
0.1304
0.1
0.1053
0.1
0.125
0.1
0.1
0.1
0.1
0.1
0.3529
0.1304
0.1

0.1538
0.1739
0.1
0.1667
0.3333
0.1765
0.1364
0.1667
0.3333
0.1667
0.2
0.2
0.2
0.1667
0.2
0.4
0.2083
0.2
0.5833
0.2083
0.1
0.1
0.2
0.375
0.2
0.25
0.1111
0.119
0.1667
0.1818
0.1818
0.1429
0.4167
0.1429
0.1
0.1429
0.1429
0.1667
0.1538
0.25
0.1667
0.2
0.3333
0.3
0.2727
0.2222
0.3333
0.3
0.1
0.1111
0.1111
0.1
0.15
0.1818
0.125
0.2143
0.1667
0.15
0.25
0.1176
0.1333
0.1
0.36
0.125
0.3333
0.3684
0.1
0.1875
0.2727
0.2
0.2222
0.5571
0.1667
0.1719
0.1899
0.1765
0.1111
0.2308
0.5
0.1333
0.1
0.1053
0.1538
0.2
0.1053
0.125
0.1333
0.1538
0.1
0.1818
0.1818
0.1176
0.2963
0.7143
0.1818
0.1

2
8
4
6
11
6
2
2
2
3
6
4
5
3
2
6
6
4
10
8
3
3
3
7
4
9
3
11
4
4
3
3
5
4
2
3
11
3
3
2
3
6
12
9
6
6
2
5
3
3
3
2
3
6
4
4
3
3
7
5
4
2
8
6
12
12
2
5
7
3
10
14
13
8
6
6
5
7
2
5
2
2
3
12
2
4
3
5
2
2
3
3
12
4
3
2

2
4
2
4
11
3
2
2
2
2
3
2
2
2
2
3
2
2
8
4
2
2
2
6
4
7
2
4
4
2
2
2
2
2
2
2
4
2
2
2
2
2
6
2
4
3
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
4
3
11
11
2
3
4
2
4
14
2
3
3
3
2
3
2
2
2
2
2
5
2
2
2
3
2
2
2
3
8
4
2
2

[10,13]
[23,36]
[10,20]
[12,49]
[11,72]
[15,17]
[10,22]
[30,34]
[12,36]
[10,13]
[10,18]
[15,19]
[16,26]
[12,13]
[10,15]
[11,21]
[20,25]
[10,28]
[12,17]
[24,53]
[10,10]
[10,10]
[10,10]
[11,18]
[13,36]
[10,24]
[10,18]
[44,71]
[10,20]
[10,11]
[10,11]
[10,14]
[12,23]
[14,19]
[10,10]
[14,20]
[14,41]
[12,13]
[10,13]
[12,19]
[10,12]
[10,28]
[10,64]
[10,10]
[10,11]
[10,11]
[13,25]
[10,18]
[10,20]
[10,19]
[10,18]
[10,10]
[10,21]
[13,23]
[29,40]
[14,28]
[10,13]
[19,20]
[10,17]
[17,18]
[15,16]
[10,10]
[22,65]
[16,19]
[10,22]
[10,25]
[10,10]
[11,22]
[11,30]
[20,38]
[19,44]
[30,143]
[66,191]
[64,290]
[1872,4407]
[34,66]
[18,19]
[10,15]
[11,19]
[15,20]
[10,10]
[10,19]
[10,13]
[10,23]
[10,19]
[16,19]
[10,15]
[13,17]
[10,10]
[10,11]
[10,11]
[10,20]
[11,51]
[13,17]
[11,23]
[10,10]

TableS10

chr7:40003671
chr7:39993857
chr7:40101517
chr6:111041483
chr2:37727325
chr5:130757299
chr6:44505563
chr8:25421024
chr12:6828320
chr11:64601523
chr2:173936868
chr7:21914588
chr3:120618599
chr10:73180522
chr12:54652560
chr11:67030584
chr17:27841802
chr17:27842309
chr20:31431106
chr20:31437165
chr9:122202902
chr9:122347879
chr9:122191138
chr9:122191233
chr17:43406808
chr17:43406811
chr17:43408016
chr7:92075030
chr7:92075308
chr7:92076887
chr9:129592607
chr6:20954285
chr6:20642741
chr6:36754477
chr6:36754479
chr6:36754481
chr12:12766270
chr12:12766523
chr9:21960979
chr16:22265170
chr20:5119333
chr16:87402419
chr16:87402420
chr3:134788765
chr3:134791796
chr19:46733793
chr19:46733983
chr19:38562627
chr22:15998775
chr2:26857130
chr2:26870480
chr4:68023226
chr4:104288124
chr1:212903624
chr1:212886465
chr1:212883055
chr1:212897109
chr1:212887176
chr1:212886682
chr5:68541536
chr16:79619719
chr16:79603097
chr2:24897247
chr16:66420835
chr16:66422620
chr17:16186622
chr9:122964270
chr15:46818393
chr11:116783878
chr11:116747167
chr11:116788303
chr11:116788362
chr18:13059848
chr18:13104239
chr18:13106479
chr20:33542567
chr20:33545853
chr20:33555925
chr20:33549110
chr20:33545835
chr20:33551293
chr1:178329449
chr1:178346852
chr1:178256546
chr1:178350561
chr10:95278253
chr11:95172197
chr1:111527081
chr22:45459943
chr2:182110069
chr2:182110539
chr16:65529443
chr16:65534183
chr16:65535454
chr16:65526073
chr5:89725646

CDC2L5
CDC2L5
CDC2L5
CDC2L6
CDC42EP3
CDC42SE2
CDC5L
CDCA2
CDCA3
CDCA5
CDCA7
CDCA7L
CDGAP
CDH23
CDK2
CDK2AP2
CDK5R1
CDK5R1
CDK5RAP1
CDK5RAP1
CDK5RAP2
CDK5RAP2
CDK5RAP2
CDK5RAP2
CDK5RAP3
CDK5RAP3
CDK5RAP3
CDK6
CDK6
CDK6
CDK9
CDKAL1
CDKAL1
CDKN1A
CDKN1A
CDKN1A
CDKN1B
CDKN1B
CDKN2A
CDR2
CDS2
CDT1
CDT1
CDV3
CDV3
CEACAM21
CEACAM21
CEBPG
CECR5
CENPA
CENPA
CENPC1
CENPE
CENPF
CENPF
CENPF
CENPF
CENPF
CENPF
CENPH
CENPN
CENPN
CENPO
CENPT
CENPT
CENPV
CEP110
CEP152
CEP164
CEP164
CEP164
CEP164
CEP192
CEP192
CEP192
CEP250
CEP250
CEP250
CEP250
CEP250
CEP250
CEP350
CEP350
CEP350
CEP350
CEP55
CEP57
CEPT1
CERK
CERKL
CERKL
CES2
CES2
CES2
CES2
CETN3

coding_exon
mixed
UTR3
UTR3
mixed
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR5
mixed
mixed
mixed
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
mixed
UTR3
UTR5
UTR5
mixed
UTR3
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
mixed
UTR3
mixed
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR5
coding_exon

ENST00000181839:LtoP;ENST00000326351:LtoP;ENST00000340829:LtoP;

ENST00000371477:YtoN;ENST00000423012:YtoN;

ENST00000306721:Sto*;ENST00000347703:Sto*;ENST00000392567:Sto*;ENST000
ENST00000356195:DtoE;ENST00000373934:DtoE;ENST00000396561:DtoE;ENST000

ENST00000313401:NtoK;
ENST00000346416:NtoI;ENST00000357886:NtoI;ENST00000452723:NtoI;
ENST00000349780:LtoQ;ENST00000359309:LtoQ;ENST00000360190:LtoQ;ENST000
ENST00000349780:LtoH;ENST00000359309:LtoH;ENST00000360190:LtoH;ENST000

ENST00000338399:YtoF;
ENST00000338399:LtoS;

ENST00000304494:StoA;ENST00000446177:StoA;

ENST00000366955:VtoA;
ENST00000366955:LtoR;
ENST00000366955:LtoP;
ENST00000366955:GtoE;
ENST00000366955:EtoG;

ENST00000305850:NtoD;ENST00000428963:NtoD;ENST00000439957:NtoD;
ENST00000299572:MtoV;ENST00000305850:MtoV;ENST00000393335:MtoV;ENST0

ENST00000399334:Sto*;
ENST00000278935:StoP;ENST00000444913:StoP;

ENST00000325971:EtoK;ENST00000399863:EtoK;ENST00000430049:EtoK;

ENST00000342580:VtoA;ENST00000356095:VtoA;ENST00000397527:VtoA;
ENST00000342580:QtoR;ENST00000356095:QtoR;ENST00000397527:QtoR;
ENST00000342580:QtoR;ENST00000356095:QtoR;ENST00000397527:QtoR;
ENST00000342580:LtoQ;ENST00000356095:LtoQ;ENST00000397527:LtoQ;
ENST00000342580:EtoG;ENST00000356095:EtoG;ENST00000397527:EtoG;
ENST00000342580:DtoG;ENST00000356095:DtoG;ENST00000397527:DtoG;
ENST00000367607:VtoE;ENST00000419991:VtoE;
ENST00000367607:LtoQ;ENST00000419991:LtoQ;
ENST00000367607:LtoH;ENST00000419991:LtoH;

ENST00000325486:RtoG;ENST00000325542:RtoG;

ENST00000317091:QtoE;ENST00000417689:QtoE;
ENST00000317091:NtoD;

60

+
+
+

+
+
+

+
+
+

+
+

+
+
+

+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+

+
+

+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+

TtoC
TtoC
CtoA
TtoC
TtoA
TtoA
TtoA
GtoA
TtoA
AtoG
CtoA
TtoG
TtoC
TtoC
AtoG
CtoA
TtoA
TtoA
AtoT
TtoC
TtoA
TtoA
TtoC
TtoC
AtoT
TtoC
GtoA
AtoC
TtoA
CtoG
AtoG
GtoA
TtoG
AtoG
CtoG
GtoT
AtoC
AtoG
TtoG
AtoG
TtoA
AtoG
CtoA
AtoG
TtoA
AtoG
CtoT
TtoG
AtoG
GtoA
TtoC
TtoC
AtoG
TtoC
TtoG
TtoC
GtoA
AtoG
TtoC
AtoG
AtoG
AtoG
AtoC
TtoC
AtoG
TtoA
TtoC
CtoA
TtoC
TtoC
TtoC
GtoC
GtoA
TtoC
AtoG
TtoC
AtoG
AtoG
TtoA
AtoG
AtoG
TtoA
TtoA
TtoA
TtoC
GtoA
AtoG
TtoA
TtoC
TtoC
TtoC
CtoG
AtoG
TtoC
TtoC
TtoC

0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1053
0.125
0.1
0.1
0.1
0.1
0.1
0.1053
0.125
0.1
0.1
0.1
0.1333
0.1
0.1
0.1
0.1
0.125
0.1053
0.1064
0.1
0.1
0.1
0.1
0.1
0.1
0.1538
0.1282
0.2131
0.1
0.1
1
0.1
0.1
0.125
0.1053
0.1176
0.6
0.1538
0.1053
0.1
0.1071
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1212
0.1
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1053
0.1176
0.125
0.1111
0.1
0.1
0.1
0.1

0.1176
0.1333
0.1
0.1667
0.1
0.1111
0.2105
0.1176
0.1538
0.1176
0.1081
0.1
0.1176
0.1
0.1176
0.125
0.2
0.1111
0.1176
0.1429
0.1818
0.1
0.125
0.2727
0.1905
0.5714
0.2917
0.1538
0.1
0.2
0.1
0.2
0.1
0.2143
0.4583
0.6061
0.1429
0.1538
1
0.2222
0.1333
0.25
0.25
0.125
1
0.4
0.1333
0.1818
0.125
0.1
0.2
0.25
0.1538
0.2041
0.1
0.125
0.15
0.1
0.1
0.2
0.1818
0.1
0.1429
0.1538
0.2
0.1818
0.1
0.1
0.1429
0.1538
0.1667
0.1
0.1667
0.3333
0.1818
0.1
0.1429
0.1176
0.1
0.1
0.1333
0.1111
0.1818
0.1
0.1818
0.15
0.1538
0.1176
0.1429
0.1429
0.4545
0.125
0.1111
0.2
0.2222
0.2

3
7
2
3
3
3
2
2
4
3
3
2
8
2
3
4
3
4
3
5
4
2
3
7
10
20
11
6
2
5
5
3
2
6
3
6
2
2
3
6
4
7
7
5
2
5
5
2
5
2
2
3
2
9
2
4
3
3
4
3
2
4
2
3
9
2
2
3
3
5
2
3
2
2
8
2
2
3
2
2
2
2
3
2
2
6
3
5
5
5
9
4
4
7
4
5

2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
3
10
4
3
2
3
2
2
2
3
2
5
2
2
3
2
2
7
3
2
2
3
2
2
2
2
2
2
2
4
2
2
2
2
3
2
2
2
2
2
5
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
3
3

[10,17]
[10,15]
[10,10]
[10,12]
[10,10]
[10,19]
[21,30]
[17,19]
[14,16]
[10,17]
[20,38]
[10,10]
[10,17]
[10,10]
[17,19]
[16,16]
[10,15]
[10,18]
[10,17]
[14,15]
[10,12]
[10,10]
[11,16]
[10,19]
[21,30]
[14,76]
[24,86]
[10,20]
[10,10]
[10,20]
[10,10]
[10,20]
[10,10]
[13,14]
[24,41]
[36,85]
[10,14]
[10,13]
[20,50]
[10,10]
[11,15]
[14,24]
[17,25]
[16,17]
[10,11]
[15,26]
[15,38]
[10,11]
[24,29]
[10,10]
[10,10]
[10,12]
[10,13]
[10,49]
[10,10]
[10,16]
[20,33]
[10,20]
[10,10]
[11,15]
[10,11]
[10,20]
[10,14]
[10,13]
[10,30]
[10,11]
[10,20]
[10,10]
[14,20]
[10,13]
[10,12]
[10,10]
[10,12]
[10,12]
[10,22]
[10,10]
[10,14]
[10,18]
[10,10]
[10,10]
[10,15]
[10,18]
[10,11]
[10,10]
[11,12]
[17,20]
[10,13]
[11,17]
[14,19]
[14,18]
[11,24]
[18,24]
[10,18]
[10,20]
[10,10]
[10,15]

TableS10

chr2:201709339
chr3:88186689
chr21:36707199
chr22:22438021
chr7:56141552
chr7:56139606
chr7:56136830
chr7:56137013
chr7:56137022
chr7:132120345
chr8:57287998
chr11:73261499
chr5:98236081
chr5:98233361
chr5:98233358
chr5:98236134
chr5:98218942
chr1:145229803
chr15:91286133
chr15:91316139
chr15:91283941
chr15:91369477
chr15:91370630
chr15:91371324
chr15:91371351
chr17:7749996
chr17:7753229
chr12:6549583
chr12:6549585
chr12:6549598
chr12:6549614
chr12:6549764
chr8:61928506
chr8:61936202
chr8:61891539
chr14:20932930
chr14:20966046
chr14:20923485
chr16:51897748
chr16:51916270
chr16:51913025
chr16:51822915
chr16:51829786
chr11:125002790
chr22:27425893
chr12:131940090
chr12:131940091
chr12:131927447
chr12:131927741
chr1:111585505
chr1:111573927
chr1:111587578
chr11:859795
chr11:67590534
chr22:49366848
chr16:88239909
chr3:87386981
chr14:23748660
chr14:23748679
chr20:31905768
chr8:23174682
chr11:89579081
chr11:89579083
chr12:100634647
chr12:103675453
chr15:99535825
chr16:782781
chr16:781204
chr16:781946
chr2:96301012
chr16:56025530
chr19:47489929
chr19:47491577
chr19:1223788
chr19:1224161
chr16:67724961
chr12:118634535
chr13:51946049
chr12:105156624
chr11:46729608
chr11:46754439
chr9:91121381
chr2:121921385
chr2:122001886
chr2:122079747
chr2:121813765
chr3:33561293
chr1:109276646
chr1:109274287
chr4:170864926
chr16:1436357
chr16:11183319
chr12:9738756
chr12:9766435
chr6:31806360
chr6:31806393

CFLAR
CGGBP1
CHAF1B
CHCHD10
CHCHD2
CHCHD2
CHCHD2
CHCHD2
CHCHD2
CHCHD3
CHCHD7
CHCHD8
CHD1
CHD1
CHD1
CHD1
CHD1
CHD1L
CHD2
CHD2
CHD2
CHD2
CHD2
CHD2
CHD2
CHD3
CHD3
CHD4
CHD4
CHD4
CHD4
CHD4
CHD7
CHD7
CHD7
CHD8
CHD8
CHD8
CHD9
CHD9
CHD9
CHD9
CHD9
CHEK1
CHEK2
CHFR
CHFR
CHFR
CHFR
CHI3L2
CHI3L2
CHI3L2
CHID1
CHKA
CHKB
CHMP1A
CHMP2B
CHMP4A
CHMP4A
CHMP4B
CHMP7
CHORDC1
CHORDC1
CHPT1
CHST11
CHSY1
CHTF18
CHTF18
CHTF18
CIAO1
CIAPIN1
CIC
CIC
CIRBP
CIRBP
CIRH1A
CIT
CKAP2
CKAP4
CKAP5
CKAP5
CKS2
CLASP1
CLASP1
CLASP1
CLASP1
CLASP2
CLCC1
CLCC1
CLCN3
CLCN7
CLEC16A
CLEC2D
CLECL1
CLIC1
CLIC1

coding_exon
mixed
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
mixed
mixed
coding_exon
mixed
coding_exon
coding_exon
UTR3
UTR3
coding_exon
mixed
UTR3
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
mixed
mixed
UTR3
coding_exon
coding_exon
mixed
UTR3
coding_exon
mixed
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3

ENST00000395148:GtoW;
ENST00000314103:StoR;
ENST00000395422:StoR;
ENST00000395422:AtoE;

ENST00000284049:HtoR;
ENST00000284049:DtoE;

ENST00000369258:GtoD;ENST00000369259:GtoD;ENST00000431239:GtoD;
ENST00000309818:QtoR;ENST00000394196:QtoR;ENST00000420239:QtoR;
ENST00000309818:EtoG;ENST00000394196:EtoG;

ENST00000330494:VtoG;ENST00000358181:VtoG;ENST00000380358:VtoG;ENST00
ENST00000330494:AtoG;ENST00000358181:AtoG;ENST00000380358:AtoG;ENST00

ENST00000307121:VtoA;ENST00000423902:VtoA;
ENST00000307121:HtoQ;ENST00000423902:HtoQ;
ENST00000399982:RtoG;ENST00000430710:RtoG;
ENST00000399982:RtoC;ENST00000430710:RtoC;
ENST00000219084:TtoP;ENST00000398510:TtoP;ENST00000447540:TtoP;ENST000
ENST00000219084:StoP;ENST00000398510:StoP;ENST00000447540:StoP;ENST000

ENST00000266880:AtoT;ENST00000315585:AtoT;ENST00000432561:AtoT;ENST000

ENST00000369744:RtoW;ENST00000369748:RtoW;ENST00000393553:RtoW;ENST0

ENST00000406938:StoG;

ENST00000320585:QtoR;ENST00000457199:QtoR;
ENST00000229266:TtoS;
ENST00000254190:LtoP;
ENST00000262315:LtoP;ENST00000317063:LtoP;ENST00000448184:LtoP;ENST0000
ENST00000262315:LtoM;ENST00000317063:LtoM;ENST00000455171:LtoM;
ENST00000262315:AtoG;ENST00000317063:AtoG;ENST00000455171:AtoG;

ENST00000160740:RtoK;

ENST00000314423:VtoG;ENST00000352319:VtoG;ENST00000453167:VtoG;
ENST00000261833:DtoG;ENST00000392520:DtoG;ENST00000392521:DtoG;
ENST00000258607:EtoG;ENST00000378037:EtoG;ENST00000490903:EtoG;

ENST00000263710:LtoS;ENST00000397587:LtoS;ENST00000409078:LtoS;ENST0000

ENST00000347613:ItoV;ENST00000360642:ItoV;

61

+
+
+
+
+
+
+
+
+
+

+
+
+

+
+
+
+
+
+

+
+
+

+
+

+
+

+
+
+
+

+
+
+
+
+

+
+

GtoT
TtoG
TtoG
AtoG
AtoC
CtoA
TtoG
GtoC
TtoC
AtoG
AtoG
GtoA
AtoG
TtoA
AtoG
TtoC
AtoG
GtoA
AtoG
AtoG
TtoA
CtoG
TtoG
TtoC
TtoC
TtoG
CtoG
GtoA
AtoG
GtoA
TtoA
TtoA
TtoC
CtoA
GtoT
CtoG
CtoT
GtoA
AtoC
TtoC
AtoG
TtoC
TtoC
TtoC
TtoC
GtoA
AtoG
GtoC
TtoG
CtoT
AtoC
TtoC
TtoA
AtoG
AtoG
AtoC
GtoT
TtoA
TtoA
AtoG
CtoG
AtoG
CtoT
AtoT
TtoC
TtoC
TtoC
CtoA
CtoG
CtoA
CtoA
GtoA
TtoG
AtoT
TtoC
TtoG
AtoG
AtoG
AtoG
TtoC
TtoC
TtoA
TtoC
TtoC
GtoA
GtoA
AtoG
AtoG
AtoC
AtoG
GtoC
TtoC
AtoG
AtoG
TtoA
TtoC

0.1
0.1
0.1
0.1
0.1053
0.1333
0.1132
0.1053
0.102
0.1
0.1
0.1
0.1053
0.1667
0.1
0.1429
0.1
0.125
0.1
0.1
0.1212
0.16
0.1071
0.1154
0.1111
0.1
0.1
0.1
0.1667
0.1
0.125
0.1
0.1053
0.1
0.1
0.1
0.1
0.1111
0.1
0.1176
0.1
0.1333
0.1429
0.1111
0.1
0.1818
0.1538
0.1667
0.1
0.125
0.1
0.1667
0.1
0.1
0.1
0.1176
0.1
0.1
0.1
0.1
0.1818
0.1
0.1
0.2
0.1
0.1
0.1
0.1
0.125
0.1053
0.1111
0.1176
0.1154
0.1111
0.1
0.1176
0.1
0.1
0.1818
0.1
0.1
0.2
0.1154
0.1
0.1667
0.1333
0.1176
0.1
0.1
0.1
0.1
0.1
0.1042
0.1
0.1818
0.1206

0.1
0.1034
0.1
0.1538
0.125
0.1579
0.1509
0.12
0.1406
0.1395
0.1
0.2
0.1667
0.1818
0.3077
0.1538
0.1111
0.1818
0.1071
0.1
0.3333
0.25
0.1935
0.1538
0.1333
0.2
0.1
0.1053
0.1765
0.1591
0.2308
0.1053
0.2
0.1
0.1
0.2222
0.1
0.1875
0.1
0.15
0.1667
0.1667
0.1875
0.125
0.2727
0.25
0.3
0.3077
0.1
1
0.1
0.4545
0.2222
0.1
0.1111
0.1333
0.1333
0.2
0.1
0.1667
0.2
0.2667
0.25
0.2727
0.1
0.1
0.1
0.1
0.2308
0.12
0.125
0.1667
0.1154
0.3158
0.125
0.2609
0.1
0.1667
0.2727
0.1333
0.16
0.2143
0.2
0.1333
0.1667
0.2143
0.2
0.3
0.1176
0.1
0.1
0.1
0.1429
0.1429
0.2778
0.1579

2
2
3
3
3
4
13
4
12
6
2
5
4
3
5
4
2
4
4
2
9
5
6
4
5
4
4
6
4
7
14
4
6
2
3
2
2
8
2
5
2
2
2
5
4
7
7
3
2
5
2
4
2
5
3
2
2
5
3
5
2
4
4
3
3
3
2
2
5
10
8
7
3
9
12
7
2
4
5
3
3
9
4
2
6
11
2
4
2
2
2
2
9
5
3
5

2
2
2
2
3
2
5
2
4
3
2
3
2
2
3
2
2
2
2
2
2
2
3
2
2
2
2
2
2
3
5
2
2
2
2
2
2
5
2
2
2
2
2
3
3
6
7
2
2
5
2
3
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
3
2
2
5
3
4
2
2
2
2
2
2
3
2
2
7
2
3
2
2
2
2
2
2
2
2

[10,10]
[10,29]
[10,10]
[10,13]
[16,19]
[15,20]
[42,59]
[19,26]
[32,100]
[10,43]
[10,10]
[10,10]
[12,19]
[11,12]
[10,13]
[13,14]
[10,45]
[11,16]
[10,28]
[10,10]
[10,33]
[12,25]
[28,35]
[13,26]
[16,18]
[10,16]
[10,10]
[10,19]
[12,17]
[14,44]
[13,24]
[19,30]
[19,20]
[10,10]
[10,10]
[10,10]
[10,10]
[14,27]
[10,10]
[17,20]
[10,12]
[12,15]
[14,16]
[16,18]
[10,15]
[10,25]
[10,26]
[12,13]
[10,10]
[12,199]
[10,10]
[11,19]
[10,10]
[10,21]
[10,18]
[16,17]
[10,15]
[10,10]
[10,10]
[10,12]
[10,11]
[10,15]
[10,12]
[10,11]
[10,30]
[10,10]
[10,10]
[10,10]
[13,16]
[19,25]
[16,18]
[17,18]
[26,26]
[16,36]
[17,20]
[16,24]
[10,11]
[12,20]
[11,11]
[10,15]
[10,25]
[15,21]
[10,26]
[10,15]
[18,18]
[11,24]
[10,17]
[10,20]
[10,17]
[10,10]
[10,10]
[10,10]
[14,48]
[20,21]
[11,19]
[61,148]

TableS10

chr5:157146393
chr12:121378650
chr12:121324633
chr12:121324642
chr12:121367263
chr12:121378890
chr7:73458195
chr2:29210099
chr2:201433156
chr2:201430781
chr2:201434207
chr15:72709461
chr12:91338919
chr16:28405406
chr11:57183883
chr11:57184884
chr11:57185046
chr11:71681264
chr19:6319885
chr15:63246143
chr15:63259552
chr1:36001348
chr1:9732172
chr1:9711696
chr1:9712103
chr12:7201362
chr12:7176996
chr17:55076590
chr17:55126822
chr6:25205379
chr12:107209101
chr1:47613509
chr1:47616993
chr16:65204919
chr3:32498322
chr3:32498346
chr3:32499254
chr3:32471328
chr3:130372816
chr3:130372812
chr3:130372980
chr3:130369543
chr3:130371109
chr3:130371110
chr18:70331924
chr18:70331922
chr18:70318149
chr19:988983
chr2:96858162
chr2:96858462
chr2:96838069
chr2:96839623
chr2:96840973
chr16:57114906
chr16:57136844
chr16:57136847
chr3:32725262
chr3:32736615
chr12:68991024
chr12:68991023
chr5:154235498
chr5:154236199
chr12:54990543
chr12:54990547
chr6:43014954
chr6:88908205
chr17:38105038
chr17:7778589
chr17:37971788
chr9:139286480
chr17:68714527
chr17:68708438
chr1:228877392
chr1:228873914
chr13:45007919
chr7:106638274
chr7:106790099
chr16:23361390
chr16:67920028
chr5:74705728
chr1:40539561
chr2:62216686
chr10:22649015
chr13:74998621
chr20:30754210
chr4:47148297
chr11:36254337
chr11:36252695
chr22:18336272
chr10:76663746
chr1:158571656
chr3:130479131
chr7:129946502
chr7:129933562
chr15:47213448
chr15:47235065

CLINT1
CLIP1
CLIP1
CLIP1
CLIP1
CLIP1
CLIP2
CLIP4
CLK1
CLK1
CLK1
CLK3
CLLU1OS
CLN3
CLP1
CLP1
CLP1
CLPB
CLPP
CLPX
CLPX
CLSPN
CLSTN1
CLSTN1
CLSTN1
CLSTN3
CLSTN3
CLTC
CLTC
CMAH
CMKLR1
CMPK1
CMPK1
CMTM3
CMTM7
CMTM7
CMTM7
CMTM7
CNBP
CNBP
CNBP
CNBP
CNBP
CNBP
CNDP2
CNDP2
CNDP2
CNN2
CNNM3
CNNM3
CNNM4
CNNM4
CNNM4
CNOT1
CNOT1
CNOT1
CNOT10
CNOT10
CNOT2
CNOT2
CNOT8
CNOT8
CNPY2
CNPY2
CNPY3
CNR1
CNTNAP1
CNTROB
COASY
COBRA1
COG1
COG1
COG2
COG2
COG3
COG5
COG5
COG7
COG8
COL4A3BP
COL9A2
COMMD1
COMMD3
COMMD6
COMMD7
COMMD8
COMMD9
COMMD9
COMT
COMTD1
COPA
COPG
COPG2
COPG2
COPS2
COPS2

UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
mixed
UTR3
UTR3
mixed
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR5
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
mixed
coding_exon
coding_exon

ENST00000302528:EtoK;ENST00000358808:EtoK;ENST00000361654:EtoK;ENST000

ENST00000320081:WtoR;ENST00000379543:WtoR;ENST00000401605:WtoR;ENST0
ENST00000321356:StoR;ENST00000434813:StoR;
ENST00000321356:LtoH;ENST00000357369:LtoH;ENST00000409769:LtoH;ENST000
ENST00000321356:GtoE;ENST00000357369:GtoE;ENST00000434813:GtoE;
ENST00000378487:*toQ;
ENST00000354630:YtoS;ENST00000355477:YtoS;ENST00000359984:YtoS;ENST0000
ENST00000302731:VtoA;ENST00000438099:VtoA;
ENST00000302731:CtoW;ENST00000438099:CtoW;

ENST00000300107:HtoR;

ENST00000361311:TtoP;ENST00000377288:TtoP;ENST00000377298:TtoP;

ENST00000266546:StoR;ENST00000331148:StoR;
ENST00000269122:ItoV;ENST00000393043:ItoV;
ENST00000377989:DtoG;ENST00000377993:DtoG;ENST00000436589:DtoG;

ENST00000307433:VtoD;ENST00000441626:VtoD;ENST00000446936:VtoD;
ENST00000307433:EtoD;ENST00000441626:EtoD;ENST00000446936:EtoD;ENST000
ENST00000307433:DtoE;ENST00000393290:DtoE;ENST00000422453:DtoE;ENST000

ENST00000324262:HtoP;ENST00000324301:HtoP;

ENST00000305510:KtoQ;ENST00000377060:KtoQ;ENST00000424641:KtoQ;
ENST00000377075:LtoV;

ENST00000328834:YtoN;ENST00000331889:YtoN;ENST00000435630:YtoN;ENST00
ENST00000229195:YtoS;ENST00000418359:YtoS;
ENST00000229195:YtoH;ENST00000418359:YtoH;

ENST00000343053:LtoP;
ENST00000299886:LtoP;ENST00000438720:LtoP;
ENST00000366668:YtoN;ENST00000366669:YtoN;

ENST00000297135:StoP;ENST00000347053:StoP;ENST00000393603:StoP;
ENST00000297135:GtoR;ENST00000347053:GtoR;ENST00000393603:GtoR;

ENST00000263401:WtoG;ENST00000452374:WtoG;

ENST00000241704:HtoQ;ENST00000368069:HtoQ;
ENST00000445977:VtoD;
ENST00000299259:StoP;ENST00000388901:StoP;
ENST00000299259:MtoI;ENST00000388901:MtoI;

62

+
+

+
+
+

+
+
+
+

+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+

+
+
+
+
+
+

+
+
+
+
+
+
+
+
+

+
+

TtoC
GtoA
CtoT
AtoG
AtoG
TtoC
TtoC
TtoC
AtoC
TtoA
GtoA
AtoG
TtoC
AtoC
TtoC
TtoG
TtoA
CtoG
TtoC
AtoG
TtoC
GtoA
AtoC
TtoC
AtoC
CtoA
GtoC
AtoG
AtoG
AtoG
GtoA
TtoC
AtoG
TtoA
AtoG
AtoG
TtoC
TtoC
TtoA
AtoT
TtoG
GtoC
GtoA
AtoG
AtoC
GtoC
AtoC
CtoT
AtoC
TtoG
CtoG
TtoC
AtoG
TtoC
AtoC
AtoC
TtoA
AtoG
AtoC
TtoC
GtoT
TtoA
AtoG
TtoC
AtoG
AtoC
TtoC
AtoG
AtoG
TtoC
TtoC
TtoC
TtoA
TtoC
TtoC
TtoC
GtoC
AtoT
TtoC
GtoA
TtoC
TtoC
CtoA
AtoG
CtoA
AtoG
TtoG
AtoG
CtoG
TtoC
TtoG
TtoA
TtoA
CtoT
TtoC
GtoC

0.1
0.1818
0.1
0.1
0.1
0.1667
0.1379
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1818
0.1
0.1
0.1053
0.1
0.1
0.125
0.1333
0.1
0.125
0.1
0.1
0.1111
0.1071
0.1
0.1
0.125
0.1333
0.1
0.1071
0.1111
0.1875
0.129
0.4444
0.1039
0.1087
0.1
0.1
0.1026
0.1744
0.1
0.1111
0.1026
0.1
0.1053
0.1
0.1176
0.1
0.125
0.1
0.1
0.1
0.1
0.1053
0.1111
0.1
0.1
0.1
0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1
0.1
0.1
0.1429
0.1111
0.1026
0.125
0.1111
0.1
0.125
0.1
0.1
0.1538
0.1111
0.1
0.1429
0.1
0.1818
0.1
0.1176

0.2
0.2
0.1111
0.1
0.1667
0.2
0.1538
0.1
0.1
0.1333
0.1667
0.1154
0.2
0.1
0.1538
0.2308
0.1
0.1
0.2
0.1
0.1053
0.2
0.1429
0.1111
0.1765
0.1
0.2
0.1538
0.1081
0.1
0.1
0.1667
0.4545
0.1
0.1333
0.1176
0.2105
0.2727
0.8824
0.2069
0.1304
0.1
0.1463
0.1053
0.2292
0.1205
0.1111
0.2593
0.1429
0.1667
0.1
0.2
0.2
0.1364
0.1538
0.1714
0.125
0.1333
0.2
0.1333
0.1
0.1538
0.2857
0.125
0.1429
0.1
0.1786
0.1818
0.125
0.1034
0.1
0.1
0.1765
0.1
0.1
0.1667
0.1667
0.1
0.2308
0.1818
0.1765
0.3529
0.1579
0.2
0.1429
0.1333
0.1
0.1
0.1923
0.1818
0.1379
0.1667
0.1
0.25
0.1333
0.2

6
4
3
2
2
2
4
7
2
3
9
2
3
2
4
3
3
3
4
3
3
3
2
11
2
3
4
3
8
2
2
3
7
2
7
4
4
3
14
18
16
3
14
9
7
3
5
8
6
6
2
2
2
2
3
4
3
2
5
3
2
5
10
7
5
2
9
3
2
6
3
3
3
3
2
3
4
2
6
6
4
19
5
3
4
6
2
2
2
5
2
5
2
2
2
5

3
2
2
2
2
2
2
2
2
2
4
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
4
2
2
2
3
2
14
16
2
2
5
2
3
2
2
5
2
2
2
2
2
2
2
2
2
2
3
2
2
2
6
2
3
2
6
2
2
3
2
2
2
2
2
2
2
2
3
4
2
17
2
2
2
2
2
2
2
2
2
2
2
2
2
4

[10,25]
[11,15]
[10,18]
[10,10]
[10,12]
[11,12]
[31,40]
[10,10]
[10,10]
[10,15]
[10,26]
[10,57]
[10,15]
[10,10]
[10,13]
[11,13]
[10,10]
[10,10]
[11,19]
[10,10]
[10,19]
[10,16]
[14,15]
[18,20]
[17,48]
[10,10]
[10,15]
[18,26]
[38,56]
[10,10]
[10,10]
[12,17]
[11,15]
[10,10]
[28,45]
[17,27]
[16,20]
[11,31]
[10,31]
[18,143]
[70,276]
[10,10]
[31,88]
[39,39]
[48,87]
[60,83]
[73,81]
[17,78]
[10,14]
[12,19]
[10,10]
[10,17]
[10,10]
[16,44]
[26,50]
[20,35]
[10,16]
[10,15]
[15,19]
[15,18]
[10,10]
[10,13]
[10,29]
[16,17]
[10,14]
[10,10]
[18,28]
[11,20]
[10,16]
[10,30]
[10,10]
[10,10]
[10,18]
[10,10]
[10,10]
[12,15]
[10,12]
[10,10]
[10,18]
[11,27]
[17,18]
[14,39]
[19,24]
[11,18]
[10,21]
[15,16]
[10,10]
[10,10]
[14,26]
[11,18]
[10,29]
[13,14]
[10,10]
[11,16]
[10,15]
[10,17]

TableS10

chr15:47205952
chr15:47206851
chr15:47206862
chr15:47207109
chr4:84206687
chr8:68118052
chr7:99527467
chr2:232380578
chr2:232380944
chr2:237663350
chr12:53031176
chr12:53031593
chr12:53031879
chr12:53031880
chr12:53005192
chr2:198032942
chr9:130136037
chr12:119425495
chr14:73497630
chr12:107563172
chr12:107563438
chr16:4344549
chr16:83156743
chr17:13946283
chr17:13946284
chr17:14052505
chr17:13913627
chr3:120871119
chr4:74149380
chr16:84398099
chr16:84398105
chr16:84398109
chr16:84370175
chr16:84370576
chr16:84370627
chr2:97631083
chr12:119360595
chr12:119360585
chr12:119360380
chr12:119360382
chr12:119360381
chr12:119362762
chr12:119362764
chr12:119362776
chr12:119362778
chr12:119362798
chr19:40841500
chr6:76020289
chr6:76010179
chr6:76004222
chr2:42431227
chr2:42431305
chr2:42431317
chr5:85952340
chr11:63500572
chr3:150367592
chr5:173312821
chr5:173317457
chr5:173319667
chr20:33678725
chr20:33678726
chr20:33703835
chr20:33704256
chr8:87640012
chr6:36822291
chr16:88190635
chr12:37373851
chr3:99782005
chr14:91698605
chr2:9517115
chr12:67931190
chr22:49362620
chr22:49362152
chr3:3166873
chr3:3167353
chr7:65255981
chr2:208169949
chr9:35726851
chr9:35726862
chr7:137239254
chr7:137210992
chr7:137210998
chr7:137211656
chr7:137212592
chr7:137214485
chr7:137214507
chr1:152212297
chr1:152213139
chr1:152212357
chr1:152213439
chr16:3741735
chr16:3768817
chr16:3840433
chr16:3840484
chr6:32191126
chr6:32191175

COPS2
COPS2
COPS2
COPS2
COPS4
COPS5
COPS6
COPS7B
COPS7B
COPS8
COPZ1
COPZ1
COPZ1
COPZ1
COPZ1
COQ10B
COQ4
COQ5
COQ6
CORO1C
CORO1C
CORO7
COTL1
COX10
COX10
COX10
COX10
COX17
COX18
COX4I1
COX4I1
COX4I1
COX4NB
COX4NB
COX4NB
COX5B
COX6A1
COX6A1
COX6A1
COX6A1
COX6A1
COX6A1
COX6A1
COX6A1
COX6A1
COX6A1
COX6B1
COX7A2
COX7A2
COX7A2
COX7A2L
COX7A2L
COX7A2L
COX7C
COX8A
CP
CPEB4
CPEB4
CPEB4
CPNE1
CPNE1
CPNE1
CPNE1
CPNE3
CPNE5
CPNE7
CPNE8
CPOX
CPSF2
CPSF3
CPSF6
CPT1B
CPT1B
CRBN
CRBN
CRCP
CREB1
CREB3
CREB3
CREB3L2
CREB3L2
CREB3L2
CREB3L2
CREB3L2
CREB3L2
CREB3L2
CREB3L4
CREB3L4
CREB3L4
CREB3L4
CREBBP
CREBBP
CREBBP
CREBBP
CREBL1
CREBL1

UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
mixed
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR5
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR5
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
coding_exon
UTR3
UTR3
coding_exon
coding_exon
mixed
mixed
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
mixed
mixed
mixed
mixed
UTR3
UTR3

ENST00000264389:TtoI;
ENST00000357849:DtoE;

ENST00000354371:VtoA;ENST00000392008:VtoA;ENST00000409334:VtoA;ENST00

ENST00000263960:PtoL;ENST00000409010:PtoL;

ENST00000238709:WtoL;ENST00000334571:WtoL;ENST00000394026:WtoL;

ENST00000261643:QtoR;
ENST00000261643:QtoH;

ENST00000229379:VtoA;
ENST00000229379:TtoA;
ENST00000229379:PtoH;
ENST00000229379:MtoL;

ENST00000265085:StoR;ENST00000326629:StoR;ENST00000334035:StoR;

ENST00000317619:YtoS;ENST00000317677:YtoS;ENST00000349942:YtoS;ENST0000
ENST00000317619:YtoH;ENST00000317677:YtoH;ENST00000349942:YtoH;ENST000

ENST00000244751:YtoD;
ENST00000331366:YtoN;

ENST00000238112:LtoP;ENST00000460593:LtoP;
ENST00000312108:GtoW;ENST00000360719:GtoW;ENST00000395650:GtoW;ENST

ENST00000330387:LtoP;ENST00000456390:LtoP;

ENST00000271889:VtoA;ENST00000368600:VtoA;ENST00000368603:VtoA;ENST00
ENST00000271889:StoP;ENST00000368600:StoP;ENST00000368603:StoP;ENST000
ENST00000271889:HtoR;ENST00000368600:HtoR;ENST00000368603:HtoR;ENST00

63

+
+
+
+
+
+
+
+
+
+
+

+
+
+
+

+
+
+

+
+
+
+
+
+
+
+
+
+
+
+

+
+

+
+
+

+
+
+

+
+
+
+

+
+
+
+

AtoG
TtoC
AtoG
TtoA
CtoT
TtoA
CtoA
TtoG
AtoC
TtoC
AtoC
TtoC
AtoG
TtoA
GtoC
CtoT
TtoC
TtoA
GtoT
TtoA
AtoG
TtoC
AtoG
AtoG
GtoT
TtoC
GtoT
AtoG
CtoG
TtoA
TtoC
AtoG
AtoG
TtoA
TtoC
TtoC
TtoC
AtoG
CtoA
AtoC
TtoG
GtoT
AtoT
CtoA
TtoA
AtoG
TtoA
AtoG
AtoC
CtoA
AtoG
TtoG
AtoG
TtoA
TtoA
GtoT
TtoA
TtoG
AtoG
AtoC
TtoC
TtoC
TtoC
TtoC
TtoG
TtoC
TtoA
AtoG
TtoC
TtoC
TtoC
GtoT
TtoG
TtoC
AtoC
AtoG
AtoG
CtoG
AtoT
TtoC
TtoG
GtoT
GtoC
AtoG
AtoG
AtoG
TtoC
TtoC
AtoG
AtoG
CtoA
TtoC
GtoA
CtoA
CtoA
TtoG

0.1
0.1
0.1034
0.1154
0.1
0.125
0.1176
0.1
0.1
0.1
0.1154
0.1154
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1176
0.1333
0.125
0.1333
0.1429
0.1
0.1176
0.1
0.125
0.1333
0.1
0.1
0.1053
0.1
0.1209
0.1
0.129
0.1154
0.12
0.1
0.1429
0.2
0.1026
0.1071
0.1
0.1143
0.1
0.1125
0.75
0.1071
0.1053
0.1216
0.12
0.2
0.1
0.1
0.1
0.1
0.1111
0.129
0.1
0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1053
0.2
0.1
0.1111
0.1053
0.1429
0.2222
0.1
0.2308
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1186

0.1667
0.1
0.1429
0.1463
0.1
0.2
0.3333
0.1
0.1818
0.2222
0.1818
0.3
0.1333
0.2727
0.1176
0.1333
0.1053
0.1
0.1176
0.1538
0.2
0.2727
0.25
0.2
0.1818
0.1538
0.1176
0.2353
0.1
0.1852
0.3333
0.1111
0.1333
0.1053
0.1
0.2381
0.2174
0.1316
0.25
0.2727
0.2727
0.3333
0.3333
0.2941
0.3
0.1
0.1463
0.1818
0.124
1
0.1364
0.3231
0.3091
0.3
0.5
0.1
0.1111
0.1
0.1538
0.5
0.3077
0.1579
0.1515
0.125
0.2
0.1
0.1
0.125
0.1333
0.1579
0.2143
0.1429
0.125
0.2
0.1111
0.1818
0.1333
0.4615
0.25
0.1429
0.3
0.5
0.25
0.1429
0.2143
0.1818
0.1
0.1333
0.1818
0.1
0.1053
0.1
0.1
0.1
0.2667
0.1923

2
3
5
4
2
7
15
2
4
2
4
9
2
2
3
2
3
4
4
8
17
10
6
2
2
4
3
7
3
15
8
4
2
6
5
3
5
6
3
4
3
6
5
11
10
4
9
3
2
8
4
5
6
9
3
2
2
3
2
11
7
6
4
6
4
4
3
3
2
5
9
2
4
2
2
5
6
3
3
4
4
6
3
7
2
3
3
3
4
2
2
4
3
2
7
8

2
2
2
2
2
3
9
2
2
2
2
3
2
2
2
2
2
2
2
3
11
8
2
2
2
2
2
2
2
3
2
2
2
2
2
3
4
2
2
4
2
4
3
4
4
2
3
2
2
8
2
3
3
6
2
2
2
2
2
9
2
2
2
3
2
2
2
2
2
2
4
2
2
2
2
4
2
3
3
2
2
4
2
3
2
2
3
2
2
2
2
2
2
2
2
3

[10,12]
[10,10]
[14,29]
[26,42]
[10,20]
[10,25]
[17,33]
[10,10]
[10,11]
[10,10]
[11,26]
[20,26]
[10,16]
[12,18]
[10,17]
[10,15]
[10,58]
[10,20]
[10,17]
[13,19]
[13,40]
[10,18]
[13,15]
[10,16]
[11,15]
[13,14]
[10,17]
[17,34]
[10,10]
[27,65]
[10,15]
[10,11]
[10,15]
[19,19]
[20,30]
[15,91]
[20,26]
[33,38]
[12,26]
[11,26]
[10,11]
[11,21]
[10,22]
[16,40]
[15,43]
[10,10]
[38,46]
[10,11]
[81,123]
[11,15]
[56,92]
[38,65]
[55,88]
[10,25]
[10,20]
[10,10]
[10,18]
[10,10]
[10,13]
[10,73]
[13,31]
[10,19]
[17,33]
[10,32]
[11,20]
[10,10]
[10,10]
[24,40]
[10,15]
[19,19]
[14,43]
[10,14]
[16,19]
[10,10]
[10,18]
[11,20]
[16,19]
[10,14]
[10,13]
[10,14]
[10,13]
[12,28]
[10,12]
[10,21]
[11,15]
[10,11]
[10,10]
[10,15]
[10,11]
[10,10]
[10,19]
[10,10]
[10,10]
[10,10]
[30,30]
[26,59]

TableS10

chr6:32191181
chr3:9961406
chr22:19638030
chr17:34940734
chr17:34872617
chr17:34872038
chr20:5934778
chr20:19972295
chr15:88970046
chr15:88987468
chr15:88987614
chr15:88988514
chr15:88989040
chr15:88989111
chr15:88989202
chr11:45861135
chr3:99146170
chr1:74943861
chr21:33925718
chr1:115062879
chr1:115062769
chr1:115061831
chr20:47140728
chr20:47122376
chr1:110273593
chr7:150565749
chr7:150566716
chr15:72882567
chr5:148865205
chr5:148866824
chr17:77804192
chr22:37017109
chr22:37017220
chr22:37017289
chr22:37019227
chr19:1931206
chr19:1931472
chr19:1932290
chr20:410608
chr20:412046
chr1:199732016
chr1:199719304
chr12:75777530
chr20:18091306
chr20:18091050
chr20:18116075
chr20:18116566
chr20:23562298
chr20:54406226
chr20:54412304
chr10:126672506
chr10:126717625
chr10:126717637
chr10:126717680
chr16:66202517
chr18:75578588
chr18:75556984
chr2:218971865
chr15:42606297
chr9:110772507
chr3:41256900
chr20:35829818
chr11:57326150
chr11:57332569
chr1:41249976
chr1:41250033
chr1:41250445
chr1:41250788
chr11:10757564
chr11:87666544
chr15:77002465
chr15:77001161
chr15:77001167
chr15:77001168
chr15:77001173
chr11:69943531
chr11:47446885
chr11:47450321
chr10:11411242
chr10:11411267
chr10:11413314
chr10:11413537
chr10:11415221
chr7:148129028
chr7:148058064
chr10:35360304
chr10:35339018
chr2:225054981
chr2:225046959
chr13:112931833
chr13:112962968
chr13:112957279
chr13:112966845
chr13:112966932
chr13:112966933
chr6:43122317

CREBL1
CRELD1
CRKL
CRKRS
CRKRS
CRKRS
CRLS1
CRNKL1
CRTC3
CRTC3
CRTC3
CRTC3
CRTC3
CRTC3
CRTC3
CRY2
CRYBG3
CRYZ
CRYZL1
CSDE1
CSDE1
CSDE1
CSE1L
CSE1L
CSF1
CSGLCAT
CSGLCAT
CSK
CSNK1A1
CSNK1A1
CSNK1D
CSNK1E
CSNK1E
CSNK1E
CSNK1E
CSNK1G2
CSNK1G2
CSNK1G2
CSNK2A1
CSNK2A1
CSRP1
CSRP1
CSRP2
CSRP2BP
CSRP2BP
CSRP2BP
CSRP2BP
CST3
CSTF1
CSTF1
CTBP2
CTBP2
CTBP2
CTBP2
CTCF
CTDP1
CTDP1
CTDSP1
CTDSPL2
CTNNAL1
CTNNB1
CTNNBL1
CTNND1
CTNND1
CTPS
CTPS
CTPS
CTPS
CTR9
CTSC
CTSH
CTSH
CTSH
CTSH
CTSH
CTTN
CUGBP1
CUGBP1
CUGBP2
CUGBP2
CUGBP2
CUGBP2
CUGBP2
CUL1
CUL1
CUL2
CUL2
CUL3
CUL3
CUL4A
CUL4A
CUL4A
CUL4A
CUL4A
CUL4A
CUL7

UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR5
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
mixed
UTR3
UTR3
mixed
mixed
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR5
UTR5
UTR5
mixed
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon

ENST00000430627:VtoE;ENST00000447079:VtoE;
ENST00000300647:Sto*;ENST00000430627:Sto*;ENST00000447079:Sto*;
ENST00000300647:LtoP;ENST00000430627:LtoP;ENST00000447079:LtoP;

ENST00000290244:LtoV;ENST00000381540:LtoV;ENST00000381554:LtoV;ENST000
ENST00000261443:KtoE;ENST00000339438:KtoE;ENST00000358528:KtoE;ENST000

ENST00000262982:AtoT;ENST00000396192:AtoT;ENST00000417408:AtoT;ENST000

ENST00000261798:KtoT;ENST00000377843:KtoT;
ENST00000314028:HtoR;ENST00000392334:HtoR;

ENST00000340006:WtoC;ENST00000367306:WtoC;ENST00000458271:WtoC;
ENST00000311083:Rto*;
ENST00000278816:VtoE;ENST00000377681:VtoE;ENST00000416635:VtoE;ENST000
ENST00000278816:ItoV;ENST00000377681:ItoV;ENST00000416635:ItoV;ENST0000
ENST00000278816:HtoL;ENST00000377681:HtoL;ENST00000416635:HtoL;ENST000

ENST00000075430:WtoG;ENST00000299543:WtoG;
ENST00000075430:KtoE;ENST00000299543:KtoE;

ENST00000325551:QtoR;ENST00000374595:QtoR;

ENST00000358694:DtoE;ENST00000360682:DtoE;ENST00000361332:DtoE;ENST000

ENST00000220166:VtoG;ENST00000394758:VtoG;ENST00000444399:VtoG;

ENST00000374742:LtoP;ENST00000374746:LtoP;ENST00000374748:LtoP;ENST0000
ENST00000264414:LtoP;ENST00000344951:LtoP;ENST00000409096:LtoP;ENST0000
ENST00000326335:WtoR;ENST00000375435:WtoR;ENST00000375440:WtoR;ENST0
ENST00000326335:QtoR;ENST00000375435:QtoR;ENST00000375440:QtoR;ENST00
ENST00000326335:LtoV;ENST00000375435:LtoV;ENST00000375440:LtoV;ENST000

ENST00000265348:MtoV;

64

+
+
+
+
+
+

+
+
+
+
+
+
+
+
+

+
+
+
+
+
+

+
+
+

+
+
+
+

+
+

+
+
+
+
+

+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+

+
+
+
+
+
+

TtoG
TtoA
GtoA
TtoA
CtoA
TtoC
GtoT
AtoG
TtoA
TtoC
GtoT
AtoC
TtoG
AtoG
TtoA
TtoC
AtoC
TtoC
TtoG
AtoG
AtoG
TtoC
GtoA
TtoC
TtoC
TtoC
TtoA
CtoA
AtoC
AtoG
AtoG
TtoC
TtoA
AtoG
AtoG
TtoC
GtoA
TtoA
TtoG
TtoG
GtoT
TtoC
CtoT
TtoA
AtoG
AtoT
GtoA
TtoC
TtoA
TtoC
CtoT
GtoT
GtoC
AtoG
AtoC
TtoG
AtoG
AtoG
CtoT
AtoG
TtoA
TtoC
TtoA
TtoC
TtoC
AtoG
TtoC
TtoA
AtoG
TtoA
TtoG
GtoA
GtoA
AtoG
TtoC
TtoC
AtoG
CtoT
TtoC
CtoA
GtoA
TtoA
AtoG
TtoC
TtoC
TtoC
AtoT
TtoC
TtoC
TtoA
AtoG
TtoG
GtoA
TtoC
AtoG
AtoG

0.129
0.1111
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.125
0.2
0.1176
0.125
0.1111
0.1087
0.1184
0.1
0.1
0.1
0.1
0.1042
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1818
0.1053
0.9756
0.1
0.5294
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.2857
0.1818
0.2143
1
0.1111
0.1667
0.1
0.2
0.1
0.1
0.1
0.1
0.1176
0.1
0.1333
0.1818
0.12
0.1
0.1111
0.1154
0.1045
0.125
0.1077
0.1026
0.1042
0.1
0.1
0.2
0.1
0.1
0.1111
0.125
0.1538
0.1
0.1053
0.1
0.1
0.1154
0.1176
0.125
0.125
0.1
0.1333
0.2
0.1
0.1

0.1935
0.1667
0.4
0.1111
0.1
0.1
0.1333
0.1
0.1
0.1667
0.1
0.1818
0.2
0.1538
0.1111
0.125
0.1
0.1667
0.2308
0.2
0.1333
0.1818
0.1429
0.1304
0.1667
0.1
0.1
0.125
0.1667
0.1579
0.1163
0.1333
0.1111
0.1667
0.1818
0.1538
0.2
0.2
0.2143
0.1333
1
0.1818
0.8333
0.1111
0.1
0.1
0.1667
0.1176
0.125
0.2
0.9091
0.4
0.4167
1
0.1111
0.3333
0.1429
0.5455
0.1
0.1538
0.1667
0.2
0.2
0.3
0.2273
0.2143
0.1818
0.1
0.1333
0.1923
0.1181
0.3077
0.1538
0.1667
0.1707
0.1111
0.1
0.2727
0.1
0.1
0.2
0.2
0.2222
0.1176
0.125
0.2143
0.1538
0.2727
0.1304
0.1538
0.1333
0.1818
0.1818
0.2308
0.3
0.1667

5
2
5
3
2
4
3
2
5
2
4
2
3
3
2
9
2
4
5
13
3
10
2
7
2
3
6
2
12
7
4
3
2
6
7
3
7
4
4
3
18
2
3
5
2
2
4
6
4
3
3
2
2
3
5
3
3
2
3
3
9
2
4
6
5
3
6
2
3
9
4
13
11
12
18
4
3
2
3
2
3
4
2
4
5
7
5
3
12
4
3
3
3
3
4
2

3
2
3
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
6
2
3
2
3
2
2
2
2
4
2
2
2
2
3
4
2
4
2
2
2
18
2
3
2
2
2
2
2
2
2
3
2
2
3
2
2
2
2
2
2
2
2
2
3
4
2
3
2
2
4
2
9
3
5
11
2
2
2
2
2
2
2
2
2
2
3
3
3
2
2
2
2
2
2
3
2

[22,33]
[10,12]
[10,19]
[10,10]
[10,10]
[10,10]
[10,15]
[10,10]
[10,10]
[10,12]
[10,20]
[10,11]
[10,10]
[10,13]
[10,18]
[10,18]
[10,10]
[16,18]
[10,14]
[10,17]
[15,16]
[12,27]
[14,47]
[23,78]
[10,12]
[10,10]
[10,10]
[10,16]
[41,50]
[19,20]
[10,43]
[10,30]
[10,18]
[10,33]
[11,19]
[14,31]
[10,17]
[11,18]
[11,14]
[16,19]
[20,109]
[10,22]
[10,17]
[10,10]
[10,10]
[10,10]
[10,18]
[17,20]
[10,16]
[10,10]
[11,14]
[10,11]
[12,14]
[10,16]
[19,27]
[12,12]
[10,14]
[10,11]
[10,10]
[10,13]
[12,21]
[10,10]
[10,17]
[10,10]
[15,27]
[12,14]
[11,25]
[10,10]
[15,18]
[13,28]
[134,144]
[11,60]
[13,65]
[17,55]
[41,147]
[10,18]
[10,11]
[10,11]
[10,10]
[10,10]
[11,18]
[10,16]
[10,13]
[10,17]
[16,19]
[10,19]
[10,18]
[11,26]
[17,24]
[13,16]
[15,16]
[20,23]
[11,15]
[14,15]
[10,10]
[10,12]

TableS10

chr6:43122631
chr6:43123940
chr6:43296595
chr6:43260529
chr6:43300100
chr6:43288948
chr6:33493507
chr6:33492314
chr10:101504328
chr10:101504379
chr10:101504380
chr10:101505634
chr7:101527397
chr11:94339159
chr11:94339158
chr11:118271569
chr5:139040879
chr5:139040571
chr5:139040886
chr5:139043348
chr5:139008341
chr3:50363951
chr3:50367296
chr6:84660030
chr2:172121682
chr15:20515200
chr15:20551650
chr15:20487364
chr15:20554531
chr15:20554558
chr15:20555000
chr5:156718606
chr5:156753835
chr5:156754451
chr16:49388090
chr16:49388116
chr16:49390840
chr16:49392572
chr16:49392578
chr2:38149965
chr17:74183307
chr19:53673135
chr7:6168836
chr7:6169380
chr2:157979781
chr2:157980074
chr22:23091500
chr22:23048563
chr22:23141615
chr2:242331725
chr1:58744323
chr1:58777085
chr3:49544799
chr11:60865904
chr5:10732983
chr5:10733501
chr9:89486358
chr9:89510940
chr4:101004023
chr2:136435478
chr1:172093635
chr19:1383538
chr19:1383577
chr19:1386059
chr19:1386158
chr17:40180352
chr17:40167045
chr2:119846535
chr16:88599266
chr16:88599763
chr7:44065567
chr8:104524359
chr14:72492104
chr14:72495737
chr14:68652888
chr14:68588512
chr14:68588837
chr14:68588993
chr14:68589250
chr4:72110440
chr1:114256077
chr10:14989196
chr10:14989248
chr3:53321417
chr3:53297343
chr3:53294009
chr3:53294887
chr3:53296130
chr12:1925589
chr11:125720822
chr4:184073651
chr5:150069649
chr5:150070168
chr5:150070297
chr5:150070604
chr3:184161770

CUL7
CUL7
CUL9
CUL9
CUL9
CUL9
CUTA
CUTA
CUTC
CUTC
CUTC
CUTC
CUX1
CWC15
CWC15
CXCR5
CXXC5
CXXC5
CXXC5
CXXC5
CXXC5
CYB561D2
CYB561D2
CYB5R4
CYBRD1
CYFIP1
CYFIP1
CYFIP1
CYFIP1
CYFIP1
CYFIP1
CYFIP2
CYFIP2
CYFIP2
CYLD
CYLD
CYLD
CYLD
CYLD
CYP1B1
CYTH1
CYTH2
CYTH3
CYTH3
CYTIP
CYTIP
CYTSA
CYTSA
CYTSA
D2HGDH
DAB1
DAB1
DAG1
DAK
DAP
DAP
DAPK1
DAPK1
DAPP1
DARS
DARS2
DAZAP1
DAZAP1
DAZAP1
DAZAP1
DBF4B
DBF4B
DBI
DBNDD1
DBNDD1
DBNL
DCAF13
DCAF4
DCAF4
DCAF5
DCAF5
DCAF5
DCAF5
DCAF5
DCK
DCLRE1B
DCLRE1C
DCLRE1C
DCP1A
DCP1A
DCP1A
DCP1A
DCP1A
DCP1B
DCPS
DCTD
DCTN4
DCTN4
DCTN4
DCTN4
DCUN1D1

coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR5
coding_exon
mixed
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
mixed
mixed
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
mixed
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon

ENST00000265348:KtoE;
ENST00000265348:EtoG;
ENST00000252050:WtoR;ENST00000354495:WtoR;ENST00000372647:WtoR;
ENST00000252050:LtoQ;ENST00000354351:LtoQ;ENST00000354495:LtoQ;ENST000
ENST00000252050:LtoP;ENST00000354495:LtoP;ENST00000372647:LtoP;
ENST00000252050:KtoE;ENST00000354495:KtoE;ENST00000372647:KtoE;

ENST00000292535:LtoP;ENST00000292538:LtoP;ENST00000338990:LtoP;ENST0000
ENST00000279839:LtoI;
ENST00000279839:LtoH;
ENST00000302517:VtoG;

ENST00000232508:LtoP;ENST00000418577:LtoP;ENST00000424512:LtoP;ENST0000

ENST00000313077:LtoP;ENST00000412127:LtoP;ENST00000435939:LtoP;
ENST00000313077:KtoR;ENST00000412127:KtoR;ENST00000435939:KtoR;
ENST00000313077:KtoE;ENST00000412127:KtoE;

ENST00000318218:YtoD;ENST00000347377:YtoD;ENST00000377576:YtoD;ENST000

ENST00000427476:AtoG;

ENST00000314328:StoP;ENST00000437398:StoP;
ENST00000314328:EtoK;ENST00000437398:EtoK;
ENST00000321264:QtoL;ENST00000342518:QtoL;ENST00000403782:QtoL;

ENST00000311463:VtoA;ENST00000394900:VtoA;

ENST00000358077:TtoA;ENST00000408954:TtoA;ENST00000469640:TtoA;ENST000
ENST00000358077:LtoP;ENST00000408954:LtoP;ENST00000469640:LtoP;ENST0000
ENST00000296414:VtoA;
ENST00000264161:VtoG;

ENST00000315005:ItoN;ENST00000393547:ItoN;

ENST00000258780:RtoG;ENST00000389369:RtoG;ENST00000414258:RtoG;ENST00
ENST00000340355:VtoL;ENST00000353777:VtoL;ENST00000358377:VtoL;ENST000
ENST00000341516:TtoA;ENST00000389997:TtoA;

ENST00000286648:QtoR;
ENST00000369563:TtoN;

ENST00000294241:QtoR;ENST00000398650:QtoR;ENST00000480258:QtoR;
ENST00000294241:QtoP;

ENST00000312820:VtoG;ENST00000357067:VtoG;ENST00000438320:VtoG;ENST00

ENST00000292782:RtoQ;ENST00000458486:RtoQ;ENST00000469954:RtoQ;

65

+
+
+
+

+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+

+
+

+
+
+

+
+
+
+
+
+
+
+

+
+
+
+

+
+

AtoG
AtoG
TtoC
TtoA
TtoC
AtoG
GtoC
TtoC
TtoA
TtoC
CtoA
AtoG
TtoC
CtoA
TtoA
AtoG
TtoG
TtoG
TtoG
GtoA
GtoA
TtoC
TtoC
AtoG
CtoG
TtoC
AtoG
AtoG
AtoG
TtoA
TtoC
TtoG
TtoA
AtoG
AtoG
TtoC
AtoG
AtoG
TtoG
TtoA
AtoG
CtoG
TtoG
CtoT
TtoA
AtoG
TtoC
GtoA
AtoG
AtoT
TtoC
TtoC
AtoG
TtoC
AtoC
AtoC
AtoG
TtoC
TtoC
TtoG
AtoG
AtoC
AtoC
TtoG
TtoC
TtoA
AtoG
TtoA
TtoC
TtoG
AtoG
TtoC
GtoC
TtoC
AtoG
TtoC
CtoG
AtoT
TtoG
AtoG
CtoA
GtoA
AtoT
AtoG
AtoC
GtoT
TtoA
GtoA
TtoC
TtoG
TtoG
CtoT
TtoC
TtoG
AtoG
GtoA

0.125
0.1
0.1
0.1
0.1
0.1
0.1071
0.15
0.1034
0.1
0.1
0.1333
0.1
0.2
0.4545
0.1333
0.1429
0.1282
0.1154
0.1364
0.1
0.1
0.1
0.1667
0.1
0.1111
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
1
0.125
0.1
0.1
0.1
0.1429
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1047
0.4202
0.1
0.1053
0.1
0.1111
0.1429
0.1053
0.1081
0.1111
0.1176
0.1
0.1
0.1
0.1
0.1053
0.1875
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1667
0.1
0.1333
0.1
0.1
1
0.1071
0.1111
0.1
0.1538
0.1071
0.1176
0.1
0.1
0.1
0.125
0.1

0.1667
0.1
0.1333
0.1
0.1667
0.1
0.1786
0.1818
0.3
0.1111
0.1176
0.15
0.1
0.4
0.6364
0.1667
0.15
0.2097
0.125
0.1579
0.1
0.1765
0.1
0.2
0.1
0.125
0.1429
0.1
0.1176
0.1111
0.1923
0.1667
0.1
0.1111
0.1
0.1
0.1
0.1
0.1818
0.1
0.1364
1
0.2222
0.1
0.3571
0.1429
0.1429
0.1
0.1
0.1818
0.1333
0.1111
0.1
0.1034
0.2
0.5366
0.1176
0.1071
0.2308
0.1429
0.1875
0.1364
0.1159
0.1429
0.1842
0.1
0.1
0.1333
0.1143
0.1176
0.25
0.1
0.1429
0.1818
0.1
0.1
0.1667
0.1
0.1538
0.2
0.1667
0.1333
0.2
0.1176
1
0.1818
0.1667
0.1111
0.1538
0.1667
0.1667
0.1
0.1
0.1
0.1667
0.1

2
2
4
2
6
3
2
7
5
6
5
4
2
2
2
2
2
2
4
8
2
7
3
3
2
4
4
5
2
7
3
2
2
3
3
2
2
5
5
2
5
10
2
2
7
3
4
2
2
3
7
4
3
2
6
2
2
4
3
6
3
2
5
2
6
2
2
14
2
4
4
2
2
2
4
2
5
2
8
2
2
2
2
3
11
6
4
3
4
5
4
3
3
2
6
2

2
2
3
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
10
2
2
4
3
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
4
2
2
9
2
2
3
2
2
2
2
2
2
2
5
2
2
2
2
2
11
3
2
2
2
3
3
2
2
2
3
2

[12,16]
[10,20]
[10,19]
[10,10]
[10,30]
[10,10]
[28,29]
[11,20]
[10,29]
[10,18]
[10,17]
[15,20]
[10,10]
[10,10]
[11,11]
[12,15]
[20,21]
[39,62]
[40,52]
[19,22]
[10,20]
[10,17]
[10,10]
[10,12]
[10,10]
[16,18]
[14,16]
[10,10]
[17,20]
[10,18]
[10,26]
[10,12]
[10,10]
[10,18]
[10,10]
[10,10]
[10,10]
[10,10]
[10,11]
[10,10]
[17,22]
[10,21]
[10,16]
[10,10]
[10,22]
[10,16]
[14,14]
[10,10]
[10,10]
[11,19]
[10,18]
[10,18]
[10,10]
[10,29]
[41,86]
[41,257]
[10,17]
[19,28]
[10,14]
[57,64]
[14,16]
[44,57]
[70,74]
[14,27]
[17,38]
[10,10]
[10,10]
[18,51]
[10,37]
[17,19]
[10,16]
[10,10]
[10,14]
[10,11]
[10,10]
[10,10]
[10,12]
[10,10]
[10,20]
[10,12]
[10,12]
[15,16]
[10,10]
[10,17]
[10,17]
[11,28]
[12,18]
[10,18]
[13,13]
[18,28]
[17,43]
[10,10]
[10,10]
[10,10]
[12,16]
[10,10]

TableS10

chr11:102438212
chr11:60837717
chr14:52583202
chr8:38226402
chr1:15864452
chr12:56196673
chr12:56197487
chr12:56197488
chr10:73704341
chr10:73705761
chr1:20851300
chr20:3119165
chr22:22643955
chr11:108069474
chr11:108082732
chr22:37212009
chr22:37211519
chr22:37211761
chr1:112110290
chr1:112111140
chr10:70398756
chr10:70413167
chr14:93587291
chr14:93587067
chr14:93587286
chr20:47293868
chr9:134497286
chr19:14382028
chr5:176871196
chr5:176871197
chr17:59250160
chr17:59250192
chr5:134190554
chr5:134134519
chr5:134181243
chr5:134182514
chr17:59926507
chr17:59929579
chr17:59926505
chr17:59929577
chr10:70336506
chr10:70340914
chr10:70331171
chr10:70331182
chr10:70340918
chr10:70364116
chr10:70376513
chr12:122663701
chr12:122671258
chr1:198902180
chr11:118123994
chr11:118124562
chr11:118125939
chr8:91133336
chr1:159358125
chr6:18332446
chr9:125203939
chr9:125454195
chr9:125454192
chr9:125182542
chr19:6430011
chr19:6432691
chr19:6432690
chr15:63741252
chr1:152174013
chr9:19363822
chr12:16081164
chr8:124112070
chr8:124094977
chr8:124095756
chr17:5324185
chr17:5329200
chr22:22506754
chr16:10930917
chr16:10942927
chr7:24705225
chr22:17456923
chr22:18457499
chr2:234021475
chr2:234033674
chr2:74031276
chr11:70823900
chr11:70837047
chr1:26668136
chr1:26641831
chr1:26669241
chr16:70605883
chr17:32030785
chr10:12203928
chr4:24187092
chr4:24140391
chr4:24138219
chr4:24138225
chr6:30732393
chr5:54601150
chr3:47866645

DCUN1D5
DDB1
DDHD1
DDHD2
DDI2
DDIT3
DDIT3
DDIT3
DDIT4
DDIT4
DDOST
DDRGK1
DDT
DDX10
DDX10
DDX17
DDX17
DDX17
DDX20
DDX20
DDX21
DDX21
DDX24
DDX24
DDX24
DDX27
DDX31
DDX39
DDX41
DDX41
DDX42
DDX42
DDX46
DDX46
DDX46
DDX46
DDX5
DDX5
DDX5
DDX5
DDX50
DDX50
DDX50
DDX50
DDX50
DDX50
DDX50
DDX55
DDX55
DDX59
DDX6
DDX6
DDX6
DECR1
DEDD
DEK
DENND1A
DENND1A
DENND1A
DENND1A
DENND1C
DENND1C
DENND1C
DENND4A
DENND4B
DENND4C
DERA
DERL1
DERL1
DERL1
DERL2
DERL2
DERL3
DEXI
DEXI
DFNA5
DGCR2
DGCR8
DGKD
DGKD
DGUOK
DHCR7
DHCR7
DHDDS
DHDDS
DHDDS
DHODH
DHRS11
DHTKD1
DHX15
DHX15
DHX15
DHX15
DHX16
DHX29
DHX30

UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR5
UTR5
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
mixed
UTR3
UTR3
coding_exon
coding_exon
UTR3
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR5
coding_exon
mixed
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3

ENST00000319246:DtoG;ENST00000397166:DtoG;ENST00000440212:DtoG;

ENST00000322536:VtoA;ENST00000456020:VtoA;
ENST00000322536:VtoA;ENST00000456020:VtoA;

ENST00000369702:QtoR;
ENST00000354185:QtoR;
ENST00000330836:*toS;ENST00000423579:*toS;ENST00000440370:*toS;

ENST00000372153:RtoQ;ENST00000372155:RtoQ;ENST00000372159:RtoQ;
ENST00000242776:DtoE;ENST00000324340:DtoE;ENST00000451994:DtoE;ENST000

ENST00000354283:VtoG;ENST00000452510:VtoG;

ENST00000225792:QtoR;ENST00000450599:QtoR;
ENST00000225792:AtoS;ENST00000450599:AtoS;
ENST00000225792:*toK;ENST00000450599:*toK;
ENST00000373585:StoP;
ENST00000373585:RtoQ;
ENST00000373585:DtoY;

ENST00000238146:LtoP;ENST00000354291:LtoP;

ENST00000373620:TtoA;
ENST00000373618:VtoG;ENST00000373620:VtoG;ENST00000373624:VtoG;
ENST00000373618:DtoG;ENST00000373620:DtoG;ENST00000373624:DtoG;
ENST00000381480:GtoD;
ENST00000381480:EtoK;
ENST00000381480:EtoG;
ENST00000361217:WtoR;ENST00000368646:WtoR;

ENST00000158771:ItoN;
ENST00000158771:FtoI;

ENST00000342947:LtoQ;ENST00000409775:LtoQ;ENST00000409970:LtoQ;ENST000
ENST00000263196:WtoG;ENST00000447928:WtoG;
ENST00000351989:KtoE;ENST00000383024:KtoE;ENST00000407755:KtoE;
ENST00000264057:Qto*;ENST00000409813:Qto*;

ENST00000236342:VtoA;ENST00000357049:VtoA;ENST00000360009:VtoA;ENST00

ENST00000219240:VtoA;ENST00000378782:VtoA;

ENST00000336812:YtoN;
ENST00000336812:VtoA;

ENST00000251636:NtoD;

66

+
+

+
+

+
+

+
+
+
+

+
+
+
+
+
+

+
+
+
+
+
+
+
+
+

+
+

+
+
+
+

+
+
+
+
+
+

TtoC
TtoC
AtoT
AtoG
TtoC
TtoC
TtoC
AtoG
AtoG
AtoG
TtoA
GtoA
AtoG
TtoC
TtoC
AtoC
AtoG
CtoT
AtoG
AtoG
AtoG
TtoA
AtoC
TtoG
GtoC
GtoT
GtoA
TtoG
AtoG
AtoG
TtoC
AtoG
TtoG
TtoC
TtoC
AtoG
AtoG
GtoT
TtoA
AtoT
TtoC
GtoA
GtoT
GtoA
AtoG
TtoC
TtoC
TtoC
TtoC
GtoA
AtoG
AtoG
TtoA
GtoA
CtoG
TtoG
AtoG
TtoG
AtoG
AtoG
GtoA
GtoA
AtoG
TtoA
TtoC
TtoA
TtoC
TtoC
TtoC
TtoC
TtoA
TtoA
TtoC
AtoG
TtoG
TtoA
TtoG
AtoG
CtoT
GtoA
AtoG
TtoC
GtoT
TtoC
TtoC
TtoC
TtoC
GtoT
TtoG
TtoA
TtoC
TtoA
AtoG
GtoA
AtoG
TtoC

0.1111
0.9722
0.1111
0.1
0.1
0.129
0.1053
0.1
0.1053
0.1333
0.1364
0.1
0.1
0.1
0.1
0.1023
0.1053
0.1
0.1
0.1538
0.1538
0.1111
0.12
0.1
0.119
0.1
0.1
0.1167
0.1
0.1
0.1013
0.1333
0.1034
0.125
0.1053
0.12
0.1064
0.1
0.1067
0.112
0.1
0.1111
0.16
0.1379
0.1
0.1
0.1304
0.1
0.1111
0.1
0.1
0.1042
0.1
0.1053
0.1
0.1176
0.1
0.1111
0.1
0.1
0.1304
0.1111
0.1
0.1
0.1
0.1
0.1
0.1333
0.1
0.1
0.1
0.1
0.1333
0.1429
0.2
0.1
0.1
0.1111
0.1
0.4706
0.1053
0.1
0.5333
0.1
0.125
0.1
0.1
0.1
0.1111
0.1
0.1064
0.2222
0.1
0.1
0.1
0.1

0.1875
1
0.2
0.1
0.1
0.3
0.1667
0.1
0.15
0.1818
0.3704
0.1667
0.2
0.1667
0.1111
0.1319
0.3636
0.2
0.1
0.1579
0.1818
0.1538
0.1429
0.2222
0.2667
0.1429
0.1
0.1489
0.1
0.1429
0.1034
0.1765
0.1333
0.1429
0.1364
0.1429
0.12
0.1134
0.1591
0.1319
0.1538
0.1667
0.1667
0.1579
0.1176
0.1
0.16
0.1
0.1667
0.1333
0.1
0.1587
0.1
0.1163
0.1053
0.2
0.1429
0.2308
0.1
0.1053
0.1429
0.1333
0.1538
0.1538
0.1176
0.1429
0.1111
0.1667
0.1579
0.1429
0.1
0.1
0.1818
0.1579
0.2143
0.1429
0.1
0.1333
0.2
0.5
0.1667
0.1163
0.5455
0.1538
0.2727
0.1
0.1
0.1
0.1111
0.1667
0.1231
0.2857
0.1071
0.1
0.2
0.15

9
13
3
5
3
2
3
4
2
4
11
2
2
4
3
4
5
5
2
4
3
11
3
3
4
2
3
5
3
6
10
9
5
3
3
4
10
4
10
7
3
3
3
3
3
2
3
5
3
4
7
9
3
5
3
6
2
3
4
3
4
3
4
3
4
3
3
5
5
4
2
2
2
6
5
4
4
5
5
2
8
3
2
4
7
2
2
2
3
8
6
2
5
2
3
9

3
13
2
2
2
2
2
2
2
4
9
2
2
2
2
2
3
2
2
2
2
4
2
2
3
2
2
2
2
2
2
2
2
2
3
3
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
4
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
3
2
2
2
2
2

[16,24]
[11,178]
[10,10]
[10,10]
[10,10]
[10,32]
[13,19]
[10,11]
[19,20]
[12,22]
[19,47]
[10,12]
[10,10]
[10,12]
[10,18]
[88,91]
[11,19]
[11,11]
[10,20]
[13,19]
[14,22]
[10,41]
[14,25]
[10,10]
[16,42]
[10,14]
[10,10]
[47,181]
[10,10]
[10,14]
[30,80]
[15,17]
[15,29]
[21,24]
[17,22]
[14,33]
[50,94]
[98,150]
[33,75]
[92,127]
[10,13]
[18,18]
[18,25]
[19,30]
[10,17]
[10,10]
[25,46]
[10,10]
[12,18]
[10,15]
[21,30]
[28,63]
[10,10]
[19,44]
[10,19]
[10,17]
[10,14]
[10,18]
[10,10]
[10,19]
[14,23]
[15,18]
[13,20]
[10,13]
[17,20]
[11,14]
[10,20]
[12,15]
[10,19]
[10,14]
[10,10]
[10,10]
[11,15]
[14,19]
[10,14]
[21,30]
[10,10]
[15,18]
[15,20]
[16,34]
[12,19]
[40,43]
[11,15]
[10,14]
[11,16]
[10,10]
[10,10]
[10,10]
[18,27]
[20,24]
[47,67]
[10,14]
[10,28]
[10,10]
[10,10]
[10,20]

TableS10

chr17:5306382
chr17:5294967
chr17:5285209
chr12:124010854
chr12:124036606
chr12:123997344
chr16:70687873
chr16:70704237
chr2:38906616
chr2:38896250
chr2:38899595
chr17:38956821
chr17:38956866
chr17:38957184
chr12:121258280
chr12:121258455
chr13:59246325
chr14:94632042
chr14:94665696
chr20:61016186
chr5:61720613
chr5:61720636
chr12:49394499
chr12:49425846
chr12:49427686
chr2:232736487
chr2:232811563
chr11:111421163
chr7:107346923
chr13:49577189
chr3:198255912
chr3:198351497
chr3:198255205
chr20:34558868
chr14:54695029
chr1:44458924
chr19:50975066
chr7:86660605
chr7:86662677
chr19:50981633
chr5:118567028
chr15:49560583
chr10:69860283
chr10:69846613
chr10:69866844
chr16:45547916
chr4:101046735
chr4:101045852
chr2:219858590
chr7:156848642
chr10:22085650
chr10:22233482
chr3:133700731
chr3:133718344
chr12:54507616
chr12:54501223
chr1:15782318
chr15:38853904
chr11:63756515
chr17:37382058
chr1:28432104
chr10:74676466
chr16:3648038
chr16:3648040
chr3:58166285
chr12:32784674
chr12:32787935
chr19:10796797
chr19:10803567
chr10:101638609
chr10:101626185
chr2:25312137
chr2:25358093
chr2:25309927
chr2:219960095
chr20:43863480
chr20:43873432
chr2:225380632
chr2:225380633
chr2:225359995
chr2:225407171
chr19:11174362
chr5:176864352
chr5:176863573
chr16:56064582
chr9:130891469
chr6:83934343
chr19:2162751
chr19:2136890
chr11:118473914
chr16:66579366
chr17:1893444
chr3:16281325
chr3:16281379
chr1:101251906
chr1:101259848

DHX33
DHX33
DHX33
DHX37
DHX37
DHX37
DHX38
DHX38
DHX57
DHX57
DHX57
DHX8
DHX8
DHX8
DIABLO
DIABLO
DIAPH3
DICER1
DICER1
DIDO1
DIMT1L
DIMT1L
DIP2B
DIP2B
DIP2B
DIS3L2
DIS3L2
DLAT
DLD
DLEU1
DLG1
DLG1
DLG1
DLGAP4
DLGAP5
DMAP1
DMPK
DMTF1
DMTF1
DMWD
DMXL1
DMXL2
DNA2
DNA2
DNA2
DNAJA2
DNAJB14
DNAJB14
DNAJB2
DNAJB6
DNAJC1
DNAJC1
DNAJC13
DNAJC13
DNAJC14
DNAJC14
DNAJC16
DNAJC17
DNAJC4
DNAJC7
DNAJC8
DNAJC9
DNASE1
DNASE1
DNASE1L3
DNM1L
DNM1L
DNM2
DNM2
DNMBP
DNMBP
DNMT3A
DNMT3A
DNMT3A
DNPEP
DNTTIP1
DNTTIP1
DOCK10
DOCK10
DOCK10
DOCK10
DOCK6
DOK3
DOK3
DOK4
DOLPP1
DOPEY1
DOT1L
DOT1L
DPAGT1
DPEP2
DPH1
DPH3
DPH3
DPH5
DPH5

coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR5
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
mixed
coding_exon
UTR3
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
mixed
coding_exon
coding_exon
UTR3
UTR5
coding_exon
mixed
mixed
coding_exon
coding_exon
mixed
coding_exon
UTR3
coding_exon
UTR3
coding_exon
mixed
UTR3
mixed
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
mixed
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon

ENST00000225296:LtoP;ENST00000457531:LtoP;
ENST00000225296:AtoP;ENST00000433302:AtoP;ENST00000457531:AtoP;
ENST00000308736:VtoG;
ENST00000308736:KtoE;
ENST00000268482:KtoE;
ENST00000295373:RtoQ;
ENST00000295373:FtoL;

ENST00000267214:HtoQ;ENST00000267215:HtoQ;ENST00000377908:HtoQ;ENST0
ENST00000343455:DtoE;ENST00000393063:DtoE;

ENST00000199320:EtoG;
ENST00000301180:NtoD;

ENST00000273009:VtoA;ENST00000325385:VtoA;ENST00000409307:VtoA;
ENST00000280346:RtoQ;ENST00000393051:RtoQ;ENST00000452417:RtoQ;
ENST00000205402:KtoE;ENST00000417551:KtoE;ENST00000437604:KtoE;ENST000

ENST00000247191:FtoI;ENST00000341764:FtoI;ENST00000395425:FtoI;
ENST00000343373:GtoD;ENST00000348168:GtoD;ENST00000354227:GtoD;

ENST00000270223:LtoI;ENST00000377735:LtoI;
ENST00000311085:EtoK;
ENST00000433594:LtoQ;

ENST00000337833:Rto*;ENST00000442697:Rto*;
ENST00000337833:ItoK;ENST00000442697:ItoK;
ENST00000262177:HtoR;ENST00000413963:HtoR;ENST00000429029:HtoR;ENST00
ENST00000376980:VtoA;
ENST00000260818:LtoI;
ENST00000317269:LtoH;

ENST00000220496:VtoA;
ENST00000321460:HtoP;ENST00000321685:HtoP;

ENST00000372950:LtoV;

ENST00000266479:LtoH;ENST00000266481:LtoH;ENST00000358214:LtoH;ENST000
ENST00000314646:VtoG;ENST00000355667:VtoG;ENST00000359692:VtoG;ENST00
ENST00000324109:VtoA;ENST00000342239:VtoA;ENST00000393570:VtoA;
ENST00000264709:HtoR;ENST00000321117:HtoR;ENST00000380746:HtoR;ENST00

ENST00000372605:HtoQ;ENST00000372614:HtoQ;ENST00000372622:HtoQ;ENST0
ENST00000258390:NtoK;ENST00000373702:NtoK;ENST00000409592:NtoK;
ENST00000258390:NtoI;ENST00000373702:NtoI;ENST00000409592:NtoI;

ENST00000312943:KtoQ;ENST00000357198:KtoQ;ENST00000377112:KtoQ;ENST00

ENST00000237163:EtoG;ENST00000349129:EtoG;ENST00000369739:EtoG;
ENST00000221482:EtoD;ENST00000398665:EtoD;
ENST00000354202:MtoV;ENST00000409993:MtoV;ENST00000432443:MtoV;

ENST00000342173:RtoI;ENST00000370106:RtoI;ENST00000370109:RtoI;ENST0000
ENST00000342173:DtoG;ENST00000370106:DtoG;ENST00000370109:DtoG;ENST00

67

+
+

+
+
+

+
+
+
+
+
+
+
+

+
+

+
+

+
+

+
+

+
+
+
+

+
+

+
+
+
+

TtoC
GtoC
AtoT
TtoG
AtoG
TtoA
AtoG
AtoG
GtoA
TtoC
AtoG
AtoT
TtoC
TtoC
GtoA
AtoG
TtoA
TtoA
TtoC
AtoC
AtoG
AtoG
AtoG
AtoC
CtoT
TtoC
TtoC
GtoA
AtoG
AtoG
TtoC
TtoC
CtoG
AtoG
TtoA
TtoA
GtoA
CtoG
TtoA
CtoA
GtoA
GtoA
TtoA
TtoG
TtoG
TtoC
CtoT
TtoA
AtoT
AtoG
TtoC
TtoA
CtoA
TtoC
TtoA
AtoG
GtoC
TtoC
AtoC
AtoG
CtoT
CtoG
CtoT
CtoT
TtoC
TtoA
TtoA
TtoG
GtoA
TtoC
CtoA
AtoG
CtoA
TtoA
TtoG
TtoA
TtoA
TtoA
AtoT
AtoG
TtoA
CtoT
AtoC
TtoC
TtoC
AtoG
AtoG
GtoT
TtoA
AtoG
TtoC
GtoT
GtoA
GtoA
GtoT
AtoG

0.1111
0.1
0.1333
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1154
0.1
0.1
0.1
0.1
0.1333
0.1364
0.1
0.1
0.1
0.2
0.1
0.1
0.1
0.1
0.1
0.1
0.4667
0.125
0.1
0.1
0.1
0.1
0.1
0.1333
0.125
0.1
0.1
0.1
0.1
0.1
0.3125
0.1
0.1
0.1026
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.2
0.1
0.1071
0.7273
0.1
0.1
0.125
0.1
0.1304
0.1
0.1
0.1
0.1538
0.1
0.1
0.125
0.1
0.1
0.1
0.1053
0.1364
0.1042
0.1
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1034
0.1176
0.1
0.1

0.2143
0.1
0.1818
0.1
0.1
0.1
0.1034
0.125
0.1
0.1
0.1
0.1333
0.1429
0.1429
0.3
0.1786
0.1
0.1176
0.1
0.1429
0.1579
0.1538
0.1
0.1
0.1
0.2
0.1
0.1538
0.1818
0.1
0.2
0.1
0.5909
0.125
0.1
0.2
0.2
0.1429
0.1667
0.15
0.125
0.1
0.1429
0.1
0.125
0.2
0.4
0.2
0.1818
0.1333
0.3636
0.1053
0.1111
0.1
0.1818
0.2
0.1
0.1053
0.1111
0.2
0.1538
0.1333
0.7857
0.1111
0.1154
0.125
0.1
0.1667
0.1
0.1333
0.1333
0.1667
0.1
0.1053
0.1379
0.1333
0.1111
0.2
0.1667
0.2
0.1667
0.2
0.1818
0.1
0.1
0.1
0.12
0.1
0.125
0.1176
0.1
0.1
0.3913
0.1818
0.1
0.1818

3
2
3
2
2
2
4
7
2
3
2
3
4
3
4
6
3
3
2
3
6
5
2
2
2
3
2
5
6
3
3
5
2
2
3
3
2
6
7
3
2
2
2
2
3
5
3
2
2
3
6
2
2
2
5
6
3
3
6
4
2
6
3
6
3
4
2
3
3
3
2
3
2
5
5
3
4
2
2
4
4
2
8
2
2
2
2
2
3
5
2
3
4
5
2
4

2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
4
2
2
2
2
4
2
2
2
2
2
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
4
2
2

[14,18]
[10,11]
[11,15]
[10,10]
[10,10]
[10,10]
[10,29]
[16,18]
[10,10]
[10,10]
[10,10]
[10,15]
[14,17]
[10,14]
[10,12]
[26,28]
[10,10]
[10,17]
[10,10]
[10,14]
[15,19]
[13,22]
[10,10]
[10,10]
[10,10]
[10,10]
[10,10]
[10,13]
[10,11]
[10,10]
[10,25]
[10,20]
[15,22]
[16,16]
[10,10]
[10,10]
[10,10]
[10,14]
[11,12]
[15,20]
[16,16]
[10,10]
[10,14]
[10,10]
[10,16]
[10,10]
[10,16]
[10,10]
[10,11]
[15,39]
[10,41]
[19,19]
[10,18]
[10,20]
[10,11]
[10,26]
[10,10]
[20,20]
[27,45]
[10,10]
[10,13]
[15,35]
[11,14]
[10,18]
[10,26]
[16,17]
[10,10]
[23,30]
[10,10]
[10,16]
[10,15]
[12,13]
[10,10]
[10,19]
[16,29]
[10,15]
[10,11]
[10,20]
[12,19]
[11,22]
[13,49]
[10,10]
[11,16]
[20,20]
[10,10]
[10,10]
[10,25]
[10,10]
[11,26]
[17,18]
[10,10]
[10,10]
[23,29]
[11,26]
[10,10]
[10,12]

TableS10

chr20:49008458
chr1:153379026
chr9:139128755
chr9:139128590
chr15:63524509
chr15:63524675
chr19:4665114
chr19:4665110
chr19:4645802
chr12:100839291
chr12:100839292
chr22:30160165
chr22:30160172
chr6:56484022
chr6:56482426
chr6:56441754
chr20:17529435
chr20:17536857
chr1:210342893
chr1:210343230
chr2:25497593
chr11:58730248
chr10:112261285
chr1:159993267
chr17:32946718
chr12:12565637
chr2:96172669
chr8:29249102
chr3:52063035
chr15:46421597
chr15:46421611
chr15:46421899
chr15:46422277
chr15:46422714
chr18:44877822
chr18:45062386
chr14:101548481
chr14:101537742
chr14:101553304
chr14:101531293
chr3:32553522
chr3:32544979
chr16:65327648
chr16:65315065
chr21:37787277
chr21:37787275
chr12:66338107
chr12:66342538
chr12:4592939
chr20:31728446
chr20:31727185
chr1:23705644
chr3:15458215
chr3:123074303
chr16:23442024
chr16:23442292
chr16:23443180
chr5:158156060
chr1:43465342
chr13:49132910
chr10:74578084
chr10:74567798
chr10:74597636
chr1:21416529
chr6:127651595
chr6:127652225
chr15:72735372
chr15:72710133
chr16:66475801
chr16:66475807
chr3:5234190
chr3:5235444
chr3:5235445
chr9:138876631
chr12:91775347
chr11:85633492
chr11:85633577
chr6:74283487
chr6:74283957
chr6:74283958
chr6:74286508
chr6:74287476
chr6:74287477
chr2:206733586
chr2:206735873
chr2:206735874
chr2:206732768
chr2:206732863
chr19:3930885
chr19:3927055
chr19:3927059
chr16:22175654
chr3:129448483
chr3:129609858
chr3:129609968
chr5:106750835

DPM1
DPM3
DPP7
DPP7
DPP8
DPP8
DPP9
DPP9
DPP9
DRAM1
DRAM1
DRG1
DRG1
DST
DST
DST
DSTN
DSTN
DTL
DTL
DTNB
DTX4
DUSP
DUSP12
DUSP14
DUSP16
DUSP2
DUSP4
DUSP7
DUT
DUT
DUT
DUT
DUT
DYM
DYM
DYNC1H1
DYNC1H1
DYNC1H1
DYNC1H1
DYNC1LI1
DYNC1LI1
DYNC1LI2
DYNC1LI2
DYRK1A
DYRK1A
DYRK2
DYRK2
DYRK4
E2F1
E2F1
E2F2
EAF1
EAF2
EARS2
EARS2
EARS2
EBF1
EBNA1BP2
EBPL
ECD
ECD
ECD
ECE1
ECHDC1
ECHDC1
EDC3
EDC3
EDC4
EDC4
EDEM1
EDEM1
EDEM1
EDF1
EEA1
EED
EED
EEF1A1
EEF1A1
EEF1A1
EEF1A1
EEF1A1
EEF1A1
EEF1B2
EEF1B2
EEF1B2
EEF1B2
EEF1B2
EEF2
EEF2
EEF2
EEF2K
EEFSEC
EEFSEC
EEFSEC
EFNA5

coding_exon
mixed
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
mixed
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR5
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
coding_exon
coding_exon
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
mixed
UTR3
coding_exon
coding_exon
UTR5
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
coding_exon
UTR5
UTR5
UTR3
UTR3
UTR3
UTR5
UTR5
UTR5
coding_exon
UTR3
UTR3
UTR5
UTR5
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon

ENST00000443858:StoP;
ENST00000371579:AtoP;ENST00000443858:GtoA;

ENST00000262959:StoP;ENST00000262960:StoP;
ENST00000262959:HtoP;ENST00000262960:HtoP;
ENST00000262959:Eto*;ENST00000262960:Eto*;

ENST00000244364:StoC;ENST00000312431:StoC;ENST00000340834:StoC;ENST000
ENST00000244364:GtoR;ENST00000312431:GtoR;ENST00000340834:GtoR;ENST00
ENST00000246069:KtoR;ENST00000403962:KtoR;

ENST00000367943:GtoD;

ENST00000296483:NtoD;ENST00000495880:NtoD;

ENST00000269445:VtoA;ENST00000442713:VtoA;
ENST00000360184:VtoD;
ENST00000360184:StoP;
ENST00000360184:LtoM;
ENST00000360184:HtoR;
ENST00000273130:KtoE;ENST00000432458:KtoE;
ENST00000258198:FtoC;ENST00000379482:FtoC;ENST00000443351:VtoG;
ENST00000321219:LtoP;ENST00000338785:LtoP;ENST00000339659:LtoP;ENST0000
ENST00000319833:StoP;ENST00000344096:StoP;ENST00000393555:StoP;
ENST00000010132:AtoE;
ENST00000343380:EtoG;ENST00000402461:EtoG;

ENST00000372979:WtoR;ENST00000430082:WtoR;ENST00000454759:WtoR;
ENST00000372979:DtoE;ENST00000430082:DtoE;ENST00000454759:DtoE;

ENST00000315127:FtoS;ENST00000426797:FtoS;

ENST00000236957:VtoG;ENST00000392221:VtoG;ENST00000392222:VtoG;

ENST00000309311:VtoG;

ENST00000263026:KtoE;
ENST00000254730:VtoE;ENST00000483457:VtoE;

ENST00000333274:DtoN;

68

+
+
+
+

+
+
+
+

+
+
+
+

+
+
+
+
+

+
+
+
+

+
+
+
+
+

+
+

+
+
+
+
+

+
+

+
+
+
+
+

+
+
+
+

TtoC
TtoC
TtoC
GtoC
TtoC
TtoC
TtoC
AtoC
GtoT
CtoG
TtoA
TtoA
AtoG
AtoT
GtoA
CtoT
AtoG
TtoA
AtoG
CtoA
CtoT
TtoA
GtoA
GtoA
TtoC
AtoC
TtoA
AtoG
AtoG
TtoC
TtoA
TtoA
AtoG
TtoC
TtoC
TtoC
TtoA
TtoC
CtoA
AtoG
AtoG
TtoC
TtoG
AtoG
TtoC
CtoT
TtoC
TtoC
CtoA
AtoG
TtoC
AtoT
CtoA
TtoC
TtoC
TtoC
TtoC
TtoA
AtoG
AtoG
TtoC
TtoA
TtoG
AtoC
AtoG
GtoT
TtoC
TtoC
CtoG
TtoG
GtoA
TtoG
CtoA
TtoG
TtoG
GtoT
TtoG
TtoA
CtoA
CtoA
CtoG
CtoT
TtoG
TtoG
AtoG
TtoA
GtoT
TtoG
TtoG
GtoA
TtoC
AtoG
TtoA
AtoG
TtoC
GtoA

0.1111
0.1
0.4773
0.5581
0.1429
0.1
0.125
0.1429
0.1
0.1
0.1071
0.1
0.1
0.1
0.1
0.125
0.1333
0.1111
0.1
0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.12
0.1176
0.1
0.1
0.1
0.1
0.1538
0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1304
0.1
0.1579
0.1
0.1429
0.1
0.1
0.125
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.4225
0.3594
0.1071
0.1667
0.1
0.1389
0.1
0.1538
0.1176
0.1
0.1429
0.1111
0.1178
0.1061
0.1048
0.1
0.1
0.114
0.1008
0.1003
0.1
0.1
0.1
0.1667
0.1538

0.1538
0.1538
0.5065
0.6118
0.2
0.1
0.1905
0.25
0.1
0.1818
0.1429
0.1818
0.1429
0.1538
0.1
0.5
0.2
0.1818
0.1111
0.4
0.1667
0.1053
0.2174
0.1
0.1333
0.1111
0.25
0.1765
0.1
0.1
0.1
0.1
0.2222
0.3333
0.1176
0.1364
0.1538
0.125
0.1176
0.1
0.125
0.1538
0.1
0.1429
0.15
0.1
0.1429
0.1
0.1667
0.1429
0.2222
0.1667
0.1
0.1333
0.1
0.1667
0.1176
0.1579
0.1333
0.125
0.1667
0.1538
0.1667
0.2105
0.1667
0.1
0.1
0.125
0.1304
0.1
0.1
0.4514
0.4207
0.2222
0.2
0.1429
0.1538
0.1
0.4
0.4167
0.1538
0.4643
0.3871
0.1908
0.2935
0.1379
0.1
0.1667
0.1161
0.1757
0.1576
0.1
0.1111
0.1111
0.2
0.1538

2
4
2
2
5
2
4
3
2
11
8
10
5
5
3
7
3
2
4
8
3
4
4
2
3
2
4
5
2
2
2
6
3
5
4
7
4
3
4
3
4
5
2
2
3
2
2
2
8
2
3
2
2
3
2
2
4
4
4
3
6
4
5
3
3
2
2
4
8
2
3
2
2
3
3
3
6
4
4
5
5
12
11
2
17
13
4
4
2
15
17
6
2
3
3
2

2
2
2
2
2
2
3
2
2
7
4
4
2
2
2
5
2
2
2
3
3
2
3
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
4
2
3
2
2
2
2
2
2
2
2
2
2
4
2
2
2
2
2
3
4
2
2
2
2
3
2
2
3
2
3
5
3
11
7
2
16
4
2
3
2
5
11
2
2
2
2
2

[18,26]
[11,13]
[44,77]
[85,86]
[11,21]
[10,10]
[21,47]
[16,35]
[10,10]
[10,32]
[14,30]
[10,21]
[10,14]
[10,13]
[10,10]
[12,30]
[15,20]
[10,11]
[11,18]
[10,17]
[10,18]
[10,19]
[10,23]
[10,10]
[10,15]
[10,18]
[12,26]
[17,17]
[10,10]
[10,10]
[10,10]
[10,10]
[10,13]
[10,13]
[17,20]
[10,22]
[10,13]
[10,24]
[10,17]
[10,10]
[10,16]
[10,13]
[10,10]
[10,14]
[20,20]
[10,10]
[14,20]
[10,10]
[12,19]
[21,30]
[10,18]
[10,12]
[10,10]
[15,23]
[10,20]
[12,19]
[17,20]
[14,19]
[10,15]
[10,25]
[12,32]
[10,16]
[12,27]
[10,19]
[10,12]
[10,10]
[10,10]
[10,16]
[10,23]
[10,10]
[10,10]
[71,144]
[64,145]
[18,36]
[10,12]
[10,14]
[13,36]
[10,10]
[10,13]
[10,17]
[10,20]
[12,58]
[11,34]
[887,1266]
[68,201]
[30,109]
[10,10]
[10,13]
[732,1669]
[74,270]
[150,643]
[10,10]
[10,10]
[10,19]
[10,12]
[13,13]

TableS10

chr5:106744139
chr8:133093999
chr8:133094395
chr1:229566984
chr1:229567146
chr5:137832173
chr5:137832251
chr5:137832831
chr11:64377203
chr9:139772187
chr6:31968243
chr6:31962380
chr11:124957509
chr11:124951409
chr17:37100777
chr17:37100778
chr11:65520925
chr11:65521585
chr7:6030530
chr7:6030531
chr7:6030532
chr7:6030536
chr2:37203242
chr2:37180827
chr2:37181094
chr2:37181118
chr2:37181148
chr2:37181206
chr2:37181512
chr2:37181517
chr2:37181520
chr2:37181538
chr2:37181546
chr2:37181579
chr2:37181586
chr2:37181591
chr2:37181601
chr2:37186353
chr2:88638078
chr1:45113953
chr1:45119900
chr3:185338487
chr3:185338683
chr3:185371530
chr3:185384554
chr3:185442906
chr3:185458066
chr3:185458797
chr3:185509531
chr3:185509532
chr3:185532079
chr3:185535810
chr3:185535826
chr1:36158578
chr1:36161283
chr1:36161734
chr1:36161780
chr8:141618660
chr14:66919976
chr22:35236878
chr8:109330105
chr8:109330104
chr11:7965485
chr11:7973139
chr11:7973137
chr11:7974276
chr11:7974277
chr19:10091571
chr19:43819430
chr19:43819432
chr19:43819434
chr19:43819435
chr22:36614582
chr22:36614584
chr22:36614585
chr22:36614586
chr17:7422739
chr17:7422742
chr3:187989649
chr3:187990324
chr3:187990334
chr3:187990335
chr3:187984078
chr12:51720384
chr10:71854609
chr10:71834160
chr11:10785472
chr11:10775281
chr1:21078405
chr1:21085282
chr1:21140627
chr1:21168555
chr1:21149190
chr1:21168554
chr1:21098926
chr1:21059562

EFNA5
EFR3A
EFR3A
EGLN1
EGLN1
EGR1
EGR1
EGR1
EHD1
EHMT1
EHMT2
EHMT2
EI24
EI24
EIF1
EIF1
EIF1AD
EIF1AD
EIF2AK1
EIF2AK1
EIF2AK1
EIF2AK1
EIF2AK2
EIF2AK2
EIF2AK2
EIF2AK2
EIF2AK2
EIF2AK2
EIF2AK2
EIF2AK2
EIF2AK2
EIF2AK2
EIF2AK2
EIF2AK2
EIF2AK2
EIF2AK2
EIF2AK2
EIF2AK2
EIF2AK3
EIF2B3
EIF2B3
EIF2B5
EIF2B5
EIF2B5
EIF2B5
EIF2B5
EIF2B5
EIF2B5
EIF2B5
EIF2B5
EIF2B5
EIF2B5
EIF2B5
EIF2C1
EIF2C1
EIF2C1
EIF2C1
EIF2C2
EIF2S1
EIF3D
EIF3E
EIF3E
EIF3F
EIF3F
EIF3F
EIF3F
EIF3F
EIF3G
EIF3K
EIF3K
EIF3K
EIF3K
EIF3L
EIF3L
EIF3L
EIF3L
EIF4A1
EIF4A1
EIF4A2
EIF4A2
EIF4A2
EIF4A2
EIF4A2
EIF4B
EIF4EBP2
EIF4EBP2
EIF4G2
EIF4G2
EIF4G3
EIF4G3
EIF4G3
EIF4G3
EIF4G3
EIF4G3
EIF4G3
EIF4G3

UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
UTR5
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon

ENST00000375528:WtoR;ENST00000375530:WtoR;ENST00000375537:WtoR;ENST0
ENST00000375528:VtoA;ENST00000375530:VtoA;ENST00000375537:VtoA;ENST00
ENST00000343678:RtoT;

ENST00000233057:CtoW;ENST00000343510:CtoW;ENST00000395127:CtoW;ENST0

ENST00000360403:VtoA;ENST00000372183:VtoA;
ENST00000360403:DtoG;ENST00000372183:DtoG;
ENST00000273783:VtoG;ENST00000444495:VtoG;

ENST00000220592:FtoV;

ENST00000220849:MtoI;
ENST00000220849:AtoS;
ENST00000309828:PtoS;ENST00000449102:PtoS;
ENST00000309828:NtoK;ENST00000449102:NtoK;
ENST00000309828:NtoD;ENST00000449102:NtoD;

ENST00000323963:ItoK;ENST00000356531:ItoK;ENST00000440191:ItoK;

ENST00000264211:TtoP;ENST00000400422:TtoP;
ENST00000264211:QtoR;ENST00000400422:QtoR;
ENST00000264211:QtoR;ENST00000356916:QtoR;ENST00000400422:QtoR;
ENST00000264211:QtoP;ENST00000356916:QtoP;ENST00000400422:QtoP;
ENST00000264211:QtoL;ENST00000356916:QtoL;ENST00000400422:QtoL;
ENST00000264211:QtoH;ENST00000356916:QtoH;ENST00000400422:QtoH;
ENST00000264211:LtoQ;ENST00000374933:LtoQ;ENST00000400422:LtoQ;

69

+
+

+
+
+

+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

TtoA
AtoG
AtoG
GtoA
TtoG
GtoA
CtoT
TtoG
AtoG
TtoA
TtoC
TtoC
GtoC
TtoC
AtoG
TtoA
TtoA
GtoT
GtoT
CtoT
CtoT
GtoT
TtoG
TtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoT
AtoG
TtoC
AtoG
TtoG
TtoG
TtoA
AtoG
TtoC
AtoG
CtoT
AtoG
AtoG
CtoT
TtoA
AtoG
TtoG
TtoC
GtoT
AtoT
TtoG
CtoG
TtoA
GtoC
GtoT
CtoT
CtoA
AtoG
CtoA
CtoG
GtoC
TtoC
AtoG
CtoA
CtoA
AtoG
AtoG
TtoA
TtoA
TtoC
CtoA
TtoA
TtoG
GtoA
TtoC
AtoG
GtoA
AtoG
AtoG
AtoT
TtoC
AtoC
AtoG
AtoG
AtoC
AtoT
GtoT
TtoA
TtoA

0.1
0.1
0.1333
0.1
0.1
0.1
0.1
0.1429
0.3333
0.1
0.1
0.1053
0.1429
0.1
0.1011
0.1176
0.1
0.1
0.1154
0.12
0.1111
0.1333
0.1176
0.1
0.1111
0.1163
0.1
0.2308
0.1053
0.125
0.1081
0.6
0.1
0.1
0.1304
0.1053
0.2941
0.1
0.1
0.1
0.1
0.1667
0.1
0.1
0.1071
0.1
0.1
0.1
0.1429
0.1
0.5199
0.1304
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1538
0.1
0.1304
0.1053
0.1
0.1395
0.1
0.125
0.1
0.1026
0.1111
0.3684
0.3571
0.1029
0.1207
0.3
0.125
0.1
0.1154
0.1333
0.1053
0.1
0.1
0.1
0.1429
0.1
0.1
0.1026
0.1
0.125
0.1
0.1
0.1053
0.1333
0.1
0.1
0.1

0.1
0.1
0.1818
0.2
0.1053
0.1
0.1
0.1667
0.5
0.1
0.1667
0.1538
0.4
0.1154
0.211
0.3125
0.1
0.1176
0.2222
0.2632
0.1154
0.3333
0.2
0.1765
0.3478
0.2308
0.1429
0.8333
0.28
0.6429
0.2308
1
0.25
0.4615
0.5714
0.4286
0.8095
0.1818
0.1667
0.1111
0.1111
0.2857
0.2143
0.1
0.3125
0.1
0.1
0.3636
0.2381
0.1
0.5331
0.16
0.2
0.1
0.1
0.1053
0.1
0.1
0.1667
0.3077
0.5714
0.4286
0.4286
0.1111
0.48
0.1
0.2
0.1
0.2727
0.1333
0.75
0.6364
0.1373
0.3333
0.5455
0.2222
0.1538
0.1515
0.1807
0.129
0.1429
0.1818
0.2
0.1667
0.2143
0.125
0.1304
0.1272
0.125
0.1538
0.3077
0.2727
0.2
0.3
0.1
0.1818

2
3
3
5
2
3
3
3
3
3
3
7
4
3
7
7
2
2
6
7
4
2
3
7
13
6
6
9
12
17
14
17
11
16
20
18
18
2
4
4
2
9
2
2
11
2
2
2
7
3
2
3
2
2
3
2
2
3
5
7
12
11
7
3
13
5
3
2
19
11
12
2
13
16
7
2
4
4
2
2
6
3
3
3
2
2
4
18
4
2
6
5
4
6
3
8

2
2
2
3
2
2
2
2
3
2
3
3
4
2
3
4
2
2
4
4
3
2
2
2
13
2
4
8
10
17
10
17
6
13
19
17
18
2
3
2
2
6
2
2
6
2
2
2
5
2
2
2
2
2
2
2
2
2
2
5
8
7
6
2
13
3
2
2
14
3
12
2
4
10
7
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
3
3
2
5
2
2

[10,10]
[10,10]
[11,15]
[10,20]
[10,19]
[10,10]
[10,10]
[12,14]
[11,22]
[10,10]
[10,15]
[13,38]
[10,15]
[10,27]
[111,291]
[70,178]
[10,10]
[10,17]
[18,29]
[13,31]
[18,27]
[12,15]
[10,17]
[10,18]
[11,35]
[13,43]
[14,20]
[10,30]
[15,26]
[14,37]
[13,37]
[10,32]
[10,25]
[10,43]
[12,49]
[11,52]
[10,54]
[10,11]
[10,12]
[10,18]
[10,10]
[10,19]
[15,20]
[10,10]
[17,36]
[10,10]
[10,10]
[10,33]
[14,23]
[10,10]
[302,427]
[24,26]
[10,10]
[10,10]
[10,10]
[10,19]
[10,10]
[10,10]
[10,12]
[10,13]
[10,38]
[10,30]
[14,51]
[10,21]
[17,72]
[10,11]
[10,16]
[10,10]
[25,69]
[27,30]
[10,33]
[12,15]
[52,122]
[16,62]
[10,22]
[10,16]
[13,20]
[33,52]
[75,83]
[19,62]
[10,14]
[10,11]
[10,11]
[12,14]
[10,14]
[10,24]
[40,71]
[150,206]
[16,17]
[10,13]
[10,18]
[11,19]
[10,15]
[10,20]
[10,10]
[10,11]

TableS10

chr17:7156173
chr17:7156483
chr17:7156499
chr2:99382378
chr17:12836972
chr13:40454392
chr1:203850348
chr19:18416594
chr19:18414854
chr19:18414867
chr15:41852696
chr20:44429249
chr4:141694260
chr2:85470881
chr8:28026505
chr17:45813597
chr16:1768771
chr12:6950352
chr12:6958112
chr22:27941548
chr2:42375837
chr19:53521905
chr4:71740124
chr4:71740541
chr4:71740810
chr9:130623318
chr17:74595756
chr1:8845549
chr1:8854549
chr1:8854615
chr1:8850693
chr1:8846682
chr1:8857500
chr1:8848125
chr1:8845552
chr1:8844063
chr1:8854621
chr1:8854617
chr1:8854624
chr1:8861358
chr1:8843649
chr1:8843650
chr1:8843653
chr1:8843654
chr12:6902706
chr12:6903118
chr17:4800624
chr17:4799584
chr4:83601006
chr4:83601202
chr18:681070
chr18:675930
chr18:696560
chr18:663435
chr18:663447
chr18:663494
chr18:663498
chr6:46216008
chr1:148861232
chr1:148861234
chr20:25152764
chr22:39884418
chr12:131128095
chr12:131088193
chr12:131128711
chr12:131128764
chr12:131129209
chr12:131129216
chr12:131130484
chr12:131130608
chr1:29316885
chr1:29317125
chr1:29319068
chr1:29319099
chr6:131257859
chr6:131203249
chr6:131220964
chr3:136355797
chr19:16358022
chr19:16333590
chr5:96136592
chr5:96137616
chr5:96137621
chr5:65410484
chr5:65411630
chr2:127731424
chr13:102322576
chr13:102312963
chr5:60276526
chr19:47446381
chr5:172312129
chr5:172312142
chr5:172312277
chr12:29401886
chr12:29385001
chr20:33608786

EIF5A
EIF5A
EIF5A
EIF5B
ELAC2
ELF1
ELK4
ELL
ELL
ELL
ELL3
ELMO2
ELMOD2
ELMOD3
ELP3
EME1
EME2
EMG1
EMG1
EMID1
EML4
EMP3
ENAM
ENAM
ENAM
ENDOG
ENGASE
ENO1
ENO1
ENO1
ENO1
ENO1
ENO1
ENO1
ENO1
ENO1
ENO1
ENO1
ENO1
ENO1
ENO1
ENO1
ENO1
ENO1
ENO2
ENO2
ENO3
ENO3
ENOPH1
ENOPH1
ENOSF1
ENOSF1
ENOSF1
ENOSF1
ENOSF1
ENOSF1
ENOSF1
ENPP4
ENSA
ENSA
ENTPD6
EP300
EP400
EP400
EP400
EP400
EP400
EP400
EP400
EP400
EPB41
EPB41
EPB41
EPB41
EPB41L2
EPB41L2
EPB41L2
EPHB1
EPS15L1
EPS15L1
ERAP1
ERAP1
ERAP1
ERBB2IP
ERBB2IP
ERCC3
ERCC5
ERCC5
ERCC8
ERF
ERGIC1
ERGIC1
ERGIC1
ERGIC2
ERGIC2
ERGIC3

UTR3
UTR3
UTR3
UTR3
coding_exon
UTR5
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
mixed
coding_exon
UTR5
mixed
mixed
mixed
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
UTR3
UTR3
mixed
coding_exon
coding_exon
mixed
mixed
mixed
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3

ENST00000338034:VtoG;ENST00000395962:VtoG;ENST00000424152:VtoG;ENST00

ENST00000262809:YtoN;

ENST00000319359:EtoD;

ENST00000315658:StoP;ENST00000393852:StoP;ENST00000393856:StoP;ENST000

ENST00000261406:AtoV;ENST00000439543:AtoV;ENST00000451846:AtoV;

ENST00000234590:YtoN;
ENST00000234590:YtoH;
ENST00000234590:VtoL;
ENST00000234590:VtoA;
ENST00000234590:TtoP;
ENST00000234590:TtoA;
ENST00000234590:LtoP;
ENST00000234590:KtoE;
ENST00000234590:EtoD;
ENST00000234590:AtoS;
ENST00000234590:AtoD;

ENST00000323997:VtoG;ENST00000381335:VtoG;ENST00000441285:VtoG;

ENST00000251101:RtoT;ENST00000340116:RtoT;ENST00000383578:RtoT;

ENST00000321037:Cto*;ENST00000371401:Cto*;

ENST00000354989:VtoA;ENST00000360031:VtoA;ENST00000376635:VtoA;ENST00
ENST00000330386:PtoQ;ENST00000332482:PtoQ;ENST00000333577:PtoQ;ENST00
ENST00000330386:NtoD;ENST00000332482:NtoD;ENST00000333577:NtoD;ENST00

ENST00000248070:StoR;ENST00000455140:StoR;

ENST00000355739:NtoK;ENST00000375954:NtoK;
ENST00000355739:ItoK;
ENST00000265038:StoT;ENST00000426118:StoT;ENST00000426742:VtoD;
ENST00000222329:WtoG;

ENST00000201023:HtoR;ENST00000360150:HtoR;

70

+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+

+
+

+
+
+

AtoT
AtoG
GtoA
CtoA
TtoG
TtoC
TtoC
TtoA
AtoC
TtoC
AtoT
AtoG
TtoA
TtoC
TtoC
GtoT
GtoA
CtoT
TtoC
TtoC
TtoA
AtoC
TtoC
CtoG
GtoA
AtoG
GtoC
TtoA
TtoC
GtoC
TtoC
AtoC
AtoG
TtoC
AtoG
GtoT
GtoT
CtoA
AtoC
AtoG
AtoG
GtoA
TtoA
AtoG
TtoG
TtoC
TtoG
AtoG
AtoG
TtoA
GtoC
AtoG
TtoC
AtoT
TtoA
AtoT
AtoG
TtoA
CtoA
AtoG
TtoC
TtoC
CtoA
AtoG
AtoG
TtoC
TtoC
AtoG
GtoT
AtoG
TtoC
TtoA
TtoC
TtoA
AtoG
TtoC
GtoA
TtoC
TtoA
TtoG
TtoA
TtoC
TtoA
CtoA
AtoG
TtoC
TtoA
TtoA
TtoA
TtoG
GtoA
AtoC
GtoA
AtoG
GtoA
AtoG

0.1161
0.1
0.1538
0.1
0.1
0.1
0.1
0.1154
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.125
0.1053
0.1
0.1111
0.1
0.1053
0.1163
0.1458
0.1
0.1
0.1803
0.1111
0.1176
0.1048
0.1292
0.1
0.1161
0.1019
0.1522
0.1
0.1026
0.1091
0.1538
0.1
0.1053
0.1
0.1004
0.1111
0.2
0.1
0.1
0.1053
0.1818
0.1
0.1
0.1
0.1
0.1364
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1333
0.1
0.1
0.1
0.1
0.1
0.1429
0.1111
0.1
0.1
0.1
0.1667
0.15
0.1
0.1
0.1154
0.1538
0.1
0.1364
0.1176
0.1
0.1538
0.1538
0.1
0.1
0.1034
0.1
0.125
0.1
0.1
0.1053
0.1

0.2651
0.125
0.2667
0.125
0.2
0.1
0.1
0.1429
0.1
0.1
0.1111
0.1
0.1
0.1
0.125
0.2
0.1
0.2143
0.1538
0.1111
0.2
0.1429
0.3636
0.2889
0.2
0.1818
0.1176
0.3929
0.1587
0.165
0.1692
0.2581
0.1062
0.1961
0.1135
0.2414
0.1538
0.2316
0.1538
0.1818
0.1
0.1136
0.1351
0.2695
0.2941
0.6667
0.1
0.1
0.1111
0.3077
0.3333
0.1818
0.1
0.1364
0.9231
0.3889
0.1818
0.1333
0.2
0.2308
0.1053
0.1818
0.1
0.1429
0.1429
0.1
0.2308
0.1111
0.1
0.1
0.1818
0.1538
0.1333
0.1
0.1429
0.1905
0.1667
0.1
0.1429
0.1818
0.3077
0.1429
0.15
0.1538
0.1818
0.2
0.2
0.1053
0.1
0.2353
0.2727
0.5882
0.1875
0.2
0.1667
0.1538

4
5
6
7
4
2
2
2
2
2
2
2
2
3
2
3
2
4
3
2
4
2
3
6
6
2
2
8
9
11
9
4
13
9
11
6
5
15
5
2
3
12
16
18
8
4
3
6
4
4
9
3
4
6
3
14
3
3
5
7
3
3
2
4
5
2
4
2
2
2
4
3
2
4
4
5
9
3
4
7
8
4
3
2
3
7
4
6
2
4
5
4
3
3
3
7

2
2
5
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
3
2
3
4
4
2
2
7
2
3
2
3
2
6
3
2
3
10
2
2
2
2
5
17
5
4
3
2
2
2
7
2
3
2
3
9
2
3
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
3
2
3
3
2
5

[83,155]
[16,30]
[10,15]
[30,40]
[10,10]
[10,10]
[10,10]
[14,26]
[10,10]
[10,10]
[10,18]
[10,10]
[10,10]
[10,10]
[10,16]
[10,10]
[10,10]
[12,16]
[13,19]
[10,19]
[10,17]
[10,46]
[11,64]
[24,45]
[12,50]
[10,11]
[10,17]
[16,65]
[65,66]
[71,109]
[68,330]
[772,899]
[42,167]
[55,176]
[109,141]
[30,47]
[13,44]
[28,167]
[13,56]
[11,14]
[10,44]
[38,44]
[66,118]
[96,503]
[10,38]
[10,31]
[10,10]
[10,10]
[18,19]
[11,13]
[10,24]
[11,20]
[10,10]
[20,22]
[13,29]
[11,29]
[10,11]
[10,15]
[10,10]
[10,20]
[10,19]
[10,11]
[10,10]
[14,15]
[14,15]
[10,10]
[10,13]
[10,18]
[10,10]
[10,10]
[11,14]
[10,13]
[10,15]
[10,20]
[10,14]
[12,21]
[18,20]
[10,10]
[10,14]
[11,26]
[14,14]
[11,14]
[20,22]
[13,17]
[10,11]
[10,13]
[10,13]
[19,20]
[10,10]
[17,29]
[10,20]
[16,17]
[10,16]
[10,16]
[12,19]
[13,28]

TableS10

chr14:68916620
chr10:101900472
chr8:37714627
chr8:37721355
chr9:5775667
chr14:52176999
chr1:234473346
chr12:110935645
chr13:46243489
chr20:13643610
chr20:13704611
chr20:13643656
chr20:13703893
chr20:13711706
chr16:66819804
chr11:63840777
chr11:63840778
chr11:63840782
chr12:54808705
chr12:54810907
chr7:158227150
chr7:158284490
chr2:67484243
chr19:56540240
chr19:56540242
chr19:56540244
chr19:48702734
chr19:48702738
chr11:127834002
chr11:127834547
chr12:11928688
chr12:11937383
chr12:11938595
chr12:11939463
chr17:26669827
chr14:99680321
chr1:240101957
chr1:240101958
chr4:56465271
chr5:512570
chr5:512571
chr5:520388
chr7:132624217
chr7:132610446
chr7:132610437
chr7:132610451
chr7:132652638
chr7:133399893
chr1:11050694
chr9:37770561
chr16:68843118
chr16:68842242
chr16:68842243
chr16:68842297
chr16:68842300
chr16:68842315
chr16:68842350
chr16:68842379
chr4:122957504
chr4:122957623
chr11:44214461
chr11:44212273
chr11:44222536
chr1:28203513
chr1:28199088
chr1:28170309
chr1:28171360
chr17:38106886
chr17:38107711
chr17:38107897
chr7:148135649
chr7:148135656
chr1:159233356
chr1:159233360
chr1:159234396
chr6:6196046
chr6:6211828
chr1:31618424
chr8:82358198
chr8:82358158
chr8:82358165
chr11:61323721
chr11:61323722
chr11:61324581
chr5:175868000
chr5:175868614
chr15:78256956
chr16:4599962
chr16:4599153
chr1:108982788
chr17:68715686
chr17:68715898
chr5:14726774
chr5:14751542
chr10:14612490
chr10:14602487

ERH
ERLIN1
ERLIN2
ERLIN2
ERMP1
ERO1L
ERO1LB
ERP29
ESD
ESF1
ESF1
ESF1
ESF1
ESF1
ESRP2
ESRRA
ESRRA
ESRRA
ESYT1
ESYT1
ESYT2
ESYT2
ETAA1
ETFB
ETFB
ETFB
ETHE1
ETHE1
ETS1
ETS1
ETV6
ETV6
ETV6
ETV6
EVI2A
EVL
EXO1
EXO1
EXOC1
EXOC3
EXOC3
EXOC3
EXOC4
EXOC4
EXOC4
EXOC4
EXOC4
EXOC4
EXOSC10
EXOSC3
EXOSC6
EXOSC6
EXOSC6
EXOSC6
EXOSC6
EXOSC6
EXOSC6
EXOSC6
EXOSC9
EXOSC9
EXT2
EXT2
EXT2
EYA3
EYA3
EYA3
EYA3
EZH1
EZH1
EZH1
EZH2
EZH2
F11R
F11R
F11R
F13A1
F13A1
FABP3
FABP5
FABP5
FABP5
FADS1
FADS1
FADS1
FAF2
FAF2
FAH
FAM100A
FAM100A
FAM102B
FAM104A
FAM104A
FAM105B
FAM105B
FAM107B
FAM107B

UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR5
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
mixed
coding_exon
coding_exon
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
mixed
UTR3
UTR3
coding_exon
UTR3
mixed
UTR3

ENST00000276461:VtoG;ENST00000335171:VtoG;ENST00000397228:VtoG;
ENST00000276461:VtoA;ENST00000335171:VtoA;ENST00000397228:VtoA;

ENST00000354619:DtoE;

ENST00000202816:StoP;
ENST00000202816:DtoN;

ENST00000267113:EtoG;ENST00000394048:EtoG;ENST00000402331:EtoG;
ENST00000251527:AtoS;ENST00000377650:AtoS;ENST00000421679:AtoS;ENST000
ENST00000272342:StoG;

ENST00000266427:DtoA;

ENST00000247270:Eto*;ENST00000394756:Eto*;
ENST00000348581:AtoE;ENST00000366548:AtoE;ENST00000445862:AtoE;

ENST00000253861:VtoE;ENST00000393161:VtoE;
ENST00000253861:StoP;ENST00000393161:StoP;
ENST00000253861:ItoV;ENST00000393161:ItoV;

ENST00000304457:VtoA;ENST00000376936:VtoA;
ENST00000435634:VtoL;

ENST00000343631:ItoV;ENST00000358681:ItoV;

ENST00000373863:VtoA;ENST00000373864:VtoA;ENST00000373871:VtoA;

ENST00000373713:WtoR;
ENST00000297258:PtoR;ENST00000396359:PtoR;

ENST00000284274:AtoE;

71

+
+

+
+
+
+
+

+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+

+
+
+

+
+
+

+
+

TtoG
AtoC
TtoG
TtoC
AtoC
TtoA
TtoA
CtoT
TtoC
TtoC
GtoA
AtoG
TtoC
AtoG
AtoT
TtoC
AtoG
AtoG
AtoG
TtoC
GtoT
TtoA
AtoG
CtoG
AtoG
TtoC
TtoA
TtoC
AtoG
TtoG
AtoC
AtoG
TtoC
AtoG
GtoT
TtoC
CtoA
AtoG
GtoT
AtoC
GtoT
TtoC
TtoA
TtoC
AtoG
AtoC
AtoG
TtoA
TtoC
TtoC
GtoC
AtoT
AtoT
AtoG
AtoG
GtoA
CtoA
GtoT
TtoA
AtoG
AtoG
TtoC
AtoG
TtoC
TtoG
TtoG
GtoT
TtoC
TtoC
GtoT
TtoC
TtoC
AtoG
AtoG
TtoG
TtoG
AtoG
TtoA
CtoG
GtoT
TtoA
TtoG
TtoA
AtoC
GtoA
AtoT
TtoG
TtoA
TtoC
AtoG
AtoG
TtoG
CtoA
TtoC
AtoC
TtoC

0.2766
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1034
0.1
0.1
0.1
0.1
0.1538
0.1
0.1373
0.125
0.1084
0.1
0.1333
0.1
0.1
0.1
0.1818
0.1
0.125
0.1143
0.1111
0.1
0.1042
0.125
0.1429
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1176
0.1111
0.2
0.1
0.1
0.1
0.1
0.1111
0.1176
0.1053
0.1
1
0.1667
0.125
0.1
0.1034
0.1125
0.1364
0.1111
0.1
0.2353
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1739
0.1
0.15
0.1
0.1
0.1
0.1
0.1
0.1
0.1818
0.1
0.1
0.1
0.25
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.122

0.381
0.1333
0.2308
0.125
0.1
0.1304
0.1
0.1379
0.1471
0.2
0.1
0.1176
0.1333
0.16
0.1053
0.2308
0.25
0.1311
0.1176
0.1429
0.1
0.1333
0.1
0.2
0.2727
0.1818
0.1667
0.1364
0.1333
0.2105
0.1667
0.1538
0.1176
0.1
0.125
0.2121
0.1818
0.2
0.1
0.1538
0.1667
0.2632
0.1818
0.1538
0.125
0.1
0.125
0.1333
0.2
0.25
1
0.25
0.2941
0.7174
0.7105
0.5
0.6818
0.3214
0.1429
0.25
0.1333
0.2
0.1538
0.1176
0.1667
0.1304
0.1538
0.1
0.1667
0.125
0.1667
0.5
0.1667
0.1667
0.1
0.1
0.1
0.1
0.1538
0.2
0.3333
0.1
0.1667
0.1379
0.3333
0.1176
0.1429
0.1538
0.2
0.125
0.1818
0.1
0.1
0.1176
0.125
0.1429

7
2
3
3
3
4
2
3
8
2
2
5
5
3
4
6
4
17
3
4
2
2
2
2
8
5
4
9
5
8
4
2
6
4
2
8
5
5
4
7
7
2
3
4
2
4
3
5
7
4
3
6
9
12
11
9
9
8
2
4
2
2
2
3
2
3
2
3
3
2
3
7
8
3
3
3
2
2
2
4
2
2
5
7
3
5
4
3
6
2
2
3
4
3
3
3

4
2
3
2
2
2
2
2
4
2
2
3
3
2
2
3
4
7
2
2
2
2
2
2
3
4
3
5
2
4
2
2
2
2
2
3
4
4
2
3
3
2
2
3
2
2
2
2
2
3
3
3
2
11
8
7
9
2
2
2
2
2
2
2
2
2
2
2
2
2
2
6
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
3

[22,50]
[10,15]
[10,14]
[10,17]
[10,10]
[17,23]
[10,10]
[20,29]
[29,49]
[10,11]
[10,10]
[10,18]
[10,15]
[13,25]
[10,19]
[11,56]
[13,53]
[60,113]
[17,30]
[15,28]
[11,20]
[10,15]
[10,10]
[10,11]
[10,16]
[11,20]
[13,35]
[15,27]
[15,20]
[38,50]
[12,16]
[13,14]
[10,17]
[10,10]
[10,16]
[20,70]
[10,18]
[10,19]
[10,10]
[13,17]
[12,18]
[10,19]
[10,11]
[10,13]
[10,16]
[10,10]
[16,18]
[15,17]
[15,19]
[10,16]
[19,31]
[12,24]
[17,24]
[10,71]
[16,61]
[28,83]
[42,80]
[10,28]
[10,14]
[16,17]
[10,15]
[10,10]
[10,13]
[10,17]
[10,12]
[20,23]
[10,13]
[10,10]
[10,12]
[10,16]
[12,17]
[12,36]
[12,21]
[12,20]
[10,11]
[10,10]
[10,10]
[10,10]
[10,13]
[10,10]
[10,11]
[10,10]
[10,12]
[20,29]
[12,28]
[10,17]
[14,20]
[10,20]
[10,18]
[10,16]
[10,11]
[10,10]
[10,20]
[10,17]
[16,20]
[15,41]

TableS10

chr11:58676405
chr11:58650013
chr11:58650185
chr20:2764768
chr22:44102950
chr22:44105152
chr22:44102584
chr11:125637480
chr2:208186404
chr2:208186106
chr9:95248963
chr9:95249325
chr6:170469404
chr6:170555810
chr19:17394210
chr7:22966412
chr1:183026817
chr1:183029934
chr1:183030113
chr1:183030682
chr7:92044427
chr7:92033307
chr7:92044426
chr7:92048768
chr7:92046617
chr7:92037165
chr7:92057587
chr17:37987169
chr5:137301709
chr14:23679940
chr11:6192219
chr11:6189233
chr10:116592771
chr10:116613565
chr9:139257961
chr2:131524090
chr2:131525736
chr2:131522176
chr1:177310027
chr1:243072132
chr1:243071920
chr1:243071913
chr1:243072157
chr1:243073115
chr16:87327235
chr1:110397953
chr1:110398484
chr10:120869939
chr13:36494212
chr13:36496172
chr10:126298073
chr10:126300458
chr5:137712560
chr5:137712798
chr5:137712895
chr3:102987138
chr1:149236292
chr17:6294876
chr6:24977317
chr9:130851959
chr9:130850587
chr9:133125393
chr9:133125819
chr15:57586830
chr15:38817490
chr15:38817134
chr8:124880965
chr8:124881001
chr8:124880987
chr16:65523521
chr2:33662258
chr15:36564285
chr19:43585949
chr16:88404654
chr16:88358799
chr3:10113062
chr11:22603158
chr9:35066799
chr15:87617651
chr15:87660939
chr15:87660940
chr15:87661213
chr2:58284831
chr12:29377913
chr6:5314398
chr6:5314396
chr2:223212621
chr2:223144830
chr2:170096123
chr2:170094595
chr2:207359779
chr2:207339691
chr11:64645073
chr11:64645072
chr11:64645678
chr11:64644680

FAM111A
FAM111B
FAM111B
FAM113A
FAM118A
FAM118A
FAM118A
FAM118B
FAM119A
FAM119A
FAM120AOS
FAM120AOS
FAM120B
FAM120B
FAM125A
FAM126A
FAM129A
FAM129A
FAM129A
FAM129A
FAM133B
FAM133B
FAM133B
FAM133B
FAM133B
FAM133B
FAM133B
FAM134C
FAM13B
FAM158A
FAM160A2
FAM160A2
FAM160B1
FAM160B1
FAM166A
FAM168B
FAM168B
FAM168B
FAM20B
FAM36A
FAM36A
FAM36A
FAM36A
FAM36A
FAM38A
FAM40A
FAM40A
FAM45B
FAM48A
FAM48A
FAM53B
FAM53B
FAM53C
FAM53C
FAM53C
FAM55C
FAM63A
FAM64A
FAM65B
FAM73B
FAM73B
FAM78A
FAM78A
FAM81A
FAM82A2
FAM82A2
FAM91A1
FAM91A1
FAM91A1
FAM96B
FAM98A
FAM98B
FAM98C
FANCA
FANCA
FANCD2
FANCF
FANCG
FANCI
FANCI
FANCI
FANCI
FANCL
FAR2
FARS2
FARS2
FARSB
FARSB
FASTKD1
FASTKD1
FASTKD2
FASTKD2
FAU
FAU
FAU
FAU

coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
mixed
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
UTR3
UTR3
coding_exon
mixed
UTR3
coding_exon
mixed
UTR3
mixed
mixed
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3

ENST00000361723:RtoG;ENST00000420244:RtoG;ENST00000423534:RtoG;ENST00
ENST00000343597:MtoL;ENST00000435727:MtoL;
ENST00000343597:LtoR;ENST00000435727:LtoR;
ENST00000356872:PtoL;ENST00000360652:PtoL;ENST00000436952:PtoL;
ENST00000405673:AtoG;ENST00000442334:AtoG;
ENST00000216214:LtoP;ENST00000405548:LtoP;ENST00000441876:LtoP;

ENST00000272839:VtoL;ENST00000406927:VtoL;ENST00000411432:VtoL;ENST000

ENST00000476287:DtoA;
ENST00000317040:VtoG;ENST00000392702:VtoG;
ENST00000409923:WtoR;ENST00000432176:WtoR;

ENST00000427372:RtoW;ENST00000438306:RtoW;ENST00000445716:RtoW;
ENST00000427372:RtoQ;ENST00000438306:RtoQ;ENST00000445716:RtoQ;
ENST00000427372:RtoQ;ENST00000438306:RtoQ;ENST00000445716:RtoQ;
ENST00000427372:PtoQ;ENST00000438306:PtoQ;ENST00000445716:PtoQ;
ENST00000427372:KtoE;ENST00000438306:KtoE;ENST00000445716:KtoE;
ENST00000427372:DtoH;ENST00000438306:DtoH;ENST00000445716:DtoH;

ENST00000216799:QtoH;ENST00000396903:QtoH;ENST00000439499:QtoH;

ENST00000366528:RtoK;ENST00000411948:RtoK;
ENST00000366528:HtoD;ENST00000411948:HtoD;

ENST00000369795:GtoS;ENST00000369796:GtoS;
ENST00000361432:VtoA;
ENST00000350612:TtoS;ENST00000356185:TtoS;ENST00000360252:TtoS;ENST0000
ENST00000350612:RtoG;ENST00000356185:RtoG;ENST00000360252:RtoG;ENST00

ENST00000273347:TtoI;ENST00000422132:TtoI;ENST00000477909:TtoI;ENST00000

ENST00000259698:EtoG;ENST00000378023:EtoG;
ENST00000277475:WtoR;ENST00000358369:WtoR;ENST00000406926:WtoR;ENST0
ENST00000277475:ItoS;ENST00000358369:ItoS;ENST00000406926:ItoS;ENST00000

ENST00000260385:MtoV;ENST00000338376:MtoV;ENST00000397465:MtoV;ENST0
ENST00000260385:LtoP;ENST00000338376:LtoP;ENST00000397465:StoP;ENST0000
ENST00000334705:VtoI;
ENST00000334705:VtoI;
ENST00000334705:LtoR;

ENST00000252530:VtoG;ENST00000343358:VtoG;
ENST00000389301:StoP;
ENST00000389301:HtoQ;

ENST00000300027:FtoI;ENST00000310775:FtoI;ENST00000447611:FtoI;

ENST00000233741:KtoE;ENST00000402135:KtoE;ENST00000403295:KtoE;ENST000
ENST00000274680:LtoR;ENST00000324331:LtoR;ENST00000397563:LtoR;
ENST00000281828:LtoP;
ENST00000260971:PtoR;ENST00000361619:PtoR;ENST00000415956:PtoR;ENST000
ENST00000260971:KtoE;ENST00000361619:KtoE;ENST00000415956:KtoE;ENST000
ENST00000236980:VtoE;ENST00000402774:VtoE;ENST00000403094:VtoE;
ENST00000236980:StoT;ENST00000402774:StoT;ENST00000403094:StoT;
ENST00000279259:GtoS;
ENST00000279259:GtoD;

72

+
+
+

+
+
+
+

+
+
+

+
+

+
+
+
+
+
+

+
+
+

+
+
+
+

+
+

+
+
+

+
+

+
+
+
+

+
+
+

+
+

AtoG
AtoC
TtoG
CtoT
CtoG
TtoC
CtoT
TtoC
GtoT
GtoT
TtoC
GtoA
AtoC
CtoG
TtoG
TtoC
TtoA
TtoC
TtoG
GtoT
CtoT
GtoA
GtoA
CtoA
AtoG
GtoC
CtoT
AtoG
TtoC
GtoC
TtoC
AtoG
AtoT
TtoG
TtoC
TtoA
TtoC
CtoT
AtoG
GtoA
CtoG
CtoT
GtoA
TtoA
CtoT
GtoA
GtoA
TtoC
AtoT
AtoG
TtoG
TtoC
TtoG
TtoG
TtoC
CtoT
AtoG
GtoT
AtoG
TtoC
TtoG
TtoG
AtoG
AtoG
AtoG
TtoC
GtoA
GtoA
TtoG
TtoC
TtoC
TtoA
TtoG
TtoC
CtoG
TtoC
CtoT
AtoG
TtoA
AtoC
CtoA
TtoC
AtoG
TtoC
TtoG
GtoT
TtoC
TtoC
CtoG
AtoG
TtoA
GtoC
GtoA
GtoA
AtoT
TtoC

0.1
0.1
0.1
0.1
0.3333
0.1
0.1594
0.1176
0.1
0.1
0.1
0.1
0.1
0.3939
0.1
0.1
0.125
0.1064
0.1
0.1
0.1176
0.1765
0.1429
0.1
0.1
0.1
0.1818
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1667
0.1
0.1
0.1
0.1
0.1011
0.1064
0.1143
0.1029
0.1071
0.1
0.1053
0.1
0.1
0.1
0.1538
0.1
0.1
0.1429
0.1
0.1
0.1
0.1
0.1579
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1429
0.1
0.1
0.1
0.125
0.1053
0.1
0.1
0.1
0.1
0.1364
0.1
0.1
0.125
0.1333
0.125
0.1111
0.1
0.1
0.1
0.1
0.1034
0.4466
0.1333
0.1
0.1
0.2727
0.1071
0.1
0.1071
0.1905

0.1053
0.1
0.2
0.1667
0.3333
0.1538
0.6667
0.1429
0.1667
0.1
0.1053
0.1053
0.1333
0.4545
0.1333
0.1
0.2222
0.1333
0.1
0.1
0.2951
0.3333
0.1778
0.3
0.2
0.5476
0.25
0.1667
0.1818
0.1702
0.1
0.1667
0.1
0.1
0.3333
0.125
0.2105
0.1
0.125
0.125
0.2131
0.1304
0.25
0.1591
0.1053
0.1429
0.1176
0.1
0.1333
0.1667
0.1667
0.2
0.1579
0.1
0.2
0.1
0.1
0.2
0.1
0.1
0.1
0.1
0.1429
0.1
0.1
0.1667
0.1
0.1818
0.2
0.125
0.1333
0.1333
0.1538
0.1
0.3
0.2
0.1304
0.1
0.1818
0.9
0.6364
0.2222
0.1
0.1
0.1818
0.1
0.125
0.6078
0.1333
0.2143
0.1818
0.3333
0.4444
0.3182
0.1282
0.5

4
2
3
3
2
4
5
2
2
2
4
3
4
2
5
2
4
4
2
2
5
5
4
2
2
4
4
5
3
9
3
2
4
4
6
4
6
4
3
3
15
8
15
3
2
3
3
2
5
5
5
3
4
2
10
2
2
4
2
2
2
2
2
2
3
4
2
2
3
8
6
3
2
4
5
5
3
2
4
3
3
3
2
2
5
4
4
2
7
3
6
2
10
3
7
8

2
2
2
2
2
2
4
2
2
2
2
2
3
2
2
2
3
2
2
2
4
2
3
2
2
4
2
3
2
6
2
2
2
2
4
2
5
2
2
2
7
2
7
2
2
2
2
2
3
2
2
2
2
2
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
8
2
2
7

[10,19]
[10,10]
[10,10]
[12,20]
[15,15]
[10,13]
[12,69]
[14,17]
[10,12]
[10,10]
[10,19]
[10,19]
[10,15]
[22,33]
[10,15]
[10,20]
[10,17]
[16,47]
[10,10]
[10,10]
[17,61]
[12,18]
[21,45]
[10,10]
[10,10]
[10,42]
[11,20]
[18,27]
[10,11]
[10,47]
[10,10]
[10,12]
[10,10]
[10,10]
[18,40]
[10,16]
[10,20]
[20,20]
[10,16]
[72,89]
[29,75]
[23,35]
[27,87]
[28,44]
[10,19]
[14,19]
[10,17]
[10,10]
[10,15]
[13,13]
[12,31]
[10,10]
[15,19]
[10,10]
[10,30]
[10,10]
[10,11]
[10,19]
[10,10]
[10,10]
[10,10]
[10,10]
[10,14]
[10,10]
[10,10]
[12,14]
[10,10]
[10,11]
[10,10]
[16,41]
[15,19]
[10,15]
[10,13]
[10,20]
[10,10]
[14,22]
[10,23]
[10,10]
[11,16]
[10,30]
[11,32]
[10,28]
[10,10]
[10,10]
[10,11]
[10,10]
[16,29]
[51,103]
[15,15]
[10,14]
[10,11]
[11,12]
[18,56]
[10,22]
[31,43]
[10,29]

TableS10

chr15:46489609
chr12:131670635
chr19:9783341
chr16:30867377
chr13:76473312
chr4:15247332
chr4:15215939
chr4:15216340
chr16:65754252
chr16:65754255
chr9:37502716
chr9:37522055
chr9:37501389
chr2:47881317
chr2:47886872
chr2:47913083
chr2:47920138
chr2:47920306
chr19:44113451
chr10:6007450
chr12:116066931
chr14:38970662
chr14:54887796
chr14:54888594
chr14:54889489
chr14:54889491
chr5:147787487
chr5:147799493
chr5:147787492
chr5:147801846
chr5:147802027
chr5:41975312
chr5:41977131
chr2:73335529
chr2:73335677
chr1:16514300
chr1:11641457
chr1:11644396
chr1:11644592
chr6:153335140
chr22:31224796
chr6:53065559
chr5:171228377
chr9:122573460
chr9:122573461
chr9:122589934
chr9:122566365
chr9:138956702
chr9:138954712
chr9:138954713
chr4:153463028
chr4:153675543
chr19:7659663
chr19:7659665
chr19:7659666
chr19:7672995
chr14:74259787
chr14:74252442
chr14:74252414
chr14:74252433
chr14:74269190
chr14:74271420
chr11:72226105
chr11:72227069
chr1:155760958
chr1:155750805
chr1:155751511
chr1:159949958
chr8:11733878
chr8:11734171
chr8:11734176
chr1:153553455
chr11:111185602
chr17:70380586
chr17:70370239
chr15:66371054
chr11:63747580
chr9:94812410
chr9:94838062
chr17:7287119
chr8:38401297
chr6:167356098
chr6:167373561
chr12:27001830
chr1:27822669
chr1:239747217
chr1:239727757
chr2:105344151
chr1:38235321
chr18:32410465
chr11:65407967
chr6:110219387
chr7:50481914
chr7:50481106
chr7:50479508
chr7:50480390

FBN1
FBRSL1
FBXL12
FBXL19
FBXL3
FBXL5
FBXL5
FBXL5
FBXL8
FBXL8
FBXO10
FBXO10
FBXO10
FBXO11
FBXO11
FBXO11
FBXO11
FBXO11
FBXO17
FBXO18
FBXO21
FBXO33
FBXO34
FBXO34
FBXO34
FBXO34
FBXO38
FBXO38
FBXO38
FBXO38
FBXO38
FBXO4
FBXO4
FBXO41
FBXO41
FBXO42
FBXO44
FBXO44
FBXO44
FBXO5
FBXO7
FBXO9
FBXW11
FBXW2
FBXW2
FBXW2
FBXW2
FBXW5
FBXW5
FBXW5
FBXW7
FBXW7
FCER2
FCER2
FCER2
FCER2
FCF1
FCF1
FCF1
FCF1
FCF1
FCF1
FCHSD2
FCHSD2
FCRL5
FCRL5
FCRL5
FCRLA
FDFT1
FDFT1
FDFT1
FDPS
FDXACB1
FDXR
FDXR
FEM1B
FERMT3
FGD3
FGD3
FGF11
FGFR1
FGFR1OP
FGFR1OP
FGFR1OP2
FGR
FH
FH
FHL2
FHL3
FHOD3
FIBP
FIG4
FIGNL1
FIGNL1
FIGNL1
FIGNL1

UTR3
UTR3
coding_exon
UTR3
mixed
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
mixed
mixed
mixed
coding_exon
coding_exon
UTR3
coding_exon
mixed
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3

ENST00000247977:LtoR;

ENST00000341285:FtoL;ENST00000382358:FtoL;ENST00000412094:FtoL;ENST0000

ENST00000258200:StoR;
ENST00000258200:Cto*;
ENST00000276960:StoC;ENST00000432825:StoC;
ENST00000276960:ItoV;ENST00000432825:ItoV;

ENST00000379999:HtoR;ENST00000397269:HtoR;

ENST00000340253:StoP;
ENST00000296701:VtoL;ENST00000340253:VtoL;ENST00000394370:VtoL;

ENST00000281623:QtoR;

ENST00000375592:EtoD;
ENST00000251547:GtoE;ENST00000376770:GtoE;

ENST00000229758:QtoL;ENST00000367241:QtoL;
ENST00000244426:WtoR;ENST00000323557:WtoR;ENST00000370939:WtoR;
ENST00000265094:QtoR;ENST00000296933:QtoR;ENST00000393802:QtoR;
ENST00000340778:YtoD;ENST00000373926:YtoD;ENST00000444833:YtoD;
ENST00000340778:StoR;ENST00000373926:StoR;ENST00000444833:StoR;
ENST00000340778:StoP;ENST00000373926:StoP;ENST00000444833:StoP;
ENST00000325285:LtoP;

ENST00000341162:Rto*;
ENST00000341162:NtoI;
ENST00000341162:HtoY;
ENST00000341162:FtoC;

ENST00000320165:YtoD;ENST00000398006:YtoD;ENST00000428306:YtoD;ENST000
ENST00000293195:StoG;ENST00000413947:TtoA;ENST00000420580:StoG;ENST000

ENST00000337352:VtoA;ENST00000375482:VtoA;ENST00000416701:VtoA;
ENST00000293829:VtoG;
ENST00000310729:FtoV;ENST00000326324:FtoV;ENST00000335922:FtoV;ENST000
ENST00000283506:EtoV;ENST00000349556:EtoV;ENST00000366847:EtoV;ENST000
ENST00000229395:StoP;ENST00000327214:StoP;
ENST00000366560:ItoK;

ENST00000451735:QtoR;

73

+
+

+
+
+
+
+
+
+
+
+
+
+

+
+
+

+
+

+
+
+
+
+
+

+
+
+
+
+

+
+
+
+
+

+
+
+

AtoG
GtoA
TtoG
TtoC
AtoT
TtoC
AtoG
TtoC
TtoG
CtoA
CtoG
AtoG
TtoG
AtoT
CtoT
TtoG
CtoG
TtoC
GtoA
AtoG
TtoC
TtoG
TtoC
TtoC
GtoA
AtoC
TtoC
GtoC
CtoG
AtoG
AtoG
AtoG
TtoC
TtoC
TtoC
AtoT
GtoA
TtoC
TtoG
AtoT
AtoG
TtoC
AtoG
TtoG
TtoA
TtoC
TtoA
TtoC
CtoA
AtoG
TtoG
TtoG
CtoA
CtoA
TtoA
GtoT
CtoT
AtoT
CtoT
TtoG
TtoC
GtoC
TtoC
TtoG
TtoC
AtoC
TtoG
GtoA
GtoT
TtoC
AtoG
AtoG
TtoG
AtoG
TtoC
AtoC
AtoC
TtoC
AtoC
TtoG
TtoG
AtoT
TtoC
TtoC
TtoA
TtoA
AtoG
TtoC
TtoG
AtoG
GtoA
CtoA
AtoG
TtoC
TtoC
TtoC

0.1
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1111
0.1
0.1
0.125
0.1
0.1154
0.1
0.1
0.1
0.1
0.1176
0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1304
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.3846
0.1
0.1111
0.125
0.1
0.1071
0.1667
0.1176
0.1
0.1
0.1
0.1
0.1
0.15
0.1
0.1
0.1
0.1
0.1176
0.1
0.1333
0.1
0.1
0.1
0.1
0.1094
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1579
0.1
0.1
0.1
0.125
0.1
0.1
0.1176
0.1
0.1

0.1
0.1
0.1667
0.1538
0.1
0.1
0.125
0.1818
0.1765
0.15
0.1429
0.1333
0.1538
0.1818
0.119
0.1667
0.125
0.1538
0.1111
0.1364
0.1
0.1
0.1
0.1
0.1538
0.1538
0.1818
0.1333
0.1
0.1111
0.2
0.2727
0.1
0.125
0.1333
0.1
0.2632
0.1
0.2
0.1538
0.1429
0.1111
0.1333
0.1
0.1
0.1053
0.1333
0.1304
0.2
0.2
0.125
0.5
0.2
0.15
0.2121
0.1053
0.1667
0.3
0.25
0.15
0.4
0.1053
0.1429
0.1579
0.3
0.1
0.1
0.125
0.1
0.3636
0.16
0.1429
0.1053
0.1429
0.1538
0.125
0.125
0.15
0.1667
0.1
0.1
0.1
0.1
0.1364
0.2143
0.2
0.2143
0.1176
0.125
0.1
0.5
0.1
0.1
0.2
0.1
0.2

3
7
2
2
2
3
2
2
3
4
3
3
3
2
4
2
2
3
2
4
2
3
2
2
3
3
3
4
2
6
2
3
2
2
3
3
4
4
5
2
6
5
2
2
3
4
7
7
3
3
2
2
4
8
4
2
4
6
6
4
6
4
2
8
3
2
2
5
2
10
2
2
5
2
7
2
7
3
4
2
3
6
2
4
3
7
7
2
5
2
9
2
2
2
2
2

2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
3
2
2
2
3
2
2
2
2
2
3
2
3
2
2
2
2
3
4
2
4
3
3
2
2
2
2
3
2
2
2
2
2
5
2
2
2
2
2
2
4
2
3
2
2
2
2
3
2
4
2
2
2
2
9
2
2
2
2
2

[10,20]
[10,30]
[12,15]
[10,13]
[10,10]
[10,10]
[10,16]
[10,11]
[10,17]
[10,20]
[14,19]
[10,15]
[10,13]
[10,11]
[18,43]
[10,12]
[11,16]
[13,16]
[10,18]
[23,26]
[10,10]
[10,10]
[10,10]
[10,10]
[13,17]
[13,17]
[10,11]
[10,18]
[10,10]
[10,18]
[10,10]
[10,11]
[10,10]
[10,16]
[15,19]
[10,10]
[19,23]
[10,10]
[10,10]
[10,13]
[10,17]
[10,10]
[10,15]
[10,10]
[10,10]
[10,19]
[10,20]
[19,25]
[10,10]
[10,10]
[10,16]
[12,14]
[10,20]
[18,25]
[17,36]
[10,19]
[12,36]
[10,13]
[12,17]
[10,20]
[10,10]
[10,19]
[10,14]
[10,19]
[10,20]
[10,10]
[10,10]
[10,16]
[10,10]
[11,17]
[10,27]
[14,15]
[10,19]
[10,14]
[10,13]
[10,16]
[33,83]
[10,20]
[10,19]
[10,10]
[10,10]
[10,10]
[10,10]
[10,23]
[10,14]
[20,32]
[14,19]
[10,17]
[10,16]
[10,10]
[11,21]
[10,10]
[10,10]
[10,17]
[10,10]
[10,10]

TableS10

chr9:114989904
chr20:1304142
chr20:1304230
chr20:1300865
chr20:1300879
chr20:1304144
chr11:63768128
chr14:44654881
chr12:2783360
chr6:35718537
chr6:35650309
chr6:35651214
chr6:35651536
chr19:18504044
chr19:18503586
chr11:128180503
chr17:18096039
chr3:58104333
chr3:58114274
chr3:58116831
chr3:58131546
chr3:58131550
chr3:58132498
chr17:24230483
chr19:54671519
chr1:211099151
chr1:211135349
chr17:40680448
chr12:48324980
chr17:78278476
chr17:78278881
chr9:131697933
chr9:131721219
chr9:131697912
chr9:131691194
chr9:131692498
chr11:47724314
chr13:48608492
chr13:48680820
chr14:64462478
chr14:64468683
chr14:64569129
chr1:42417970
chr1:42414835
chr1:42415218
chr1:42416416
chr1:42417298
chr1:42417919
chr17:78153553
chr17:78155638
chr12:2851674
chr12:2851673
chr12:2837625
chr12:2837771
chr11:125652825
chr22:35216001
chr10:13728348
chr11:64911091
chr4:48253884
chr4:48194400
chr4:48195641
chr11:61488612
chr11:61488613
chr11:61491677
chr11:61491680
chr19:54161941
chr19:54161943
chr16:52704202
chr7:2240458
chr7:2240835
chr7:2241159
chr1:78205373
chr1:78186677
chr1:78186965
chr9:132460717
chr6:143866938
chr6:143866939
chr6:143858437
chr16:69071379
chr16:69071380
chr16:31101488
chr16:31110416
chr10:75202803
chr10:75202804
chr10:75208595
chr14:65165973
chr14:65165972
chr14:65278569
chr14:65279366
chr19:55007375
chr19:55002183
chr11:6462250
chr19:40338290
chr3:198994029
chr17:75707839
chr17:7084469

FKBP15
FKBP1A
FKBP1A
FKBP1A
FKBP1A
FKBP1A
FKBP2
FKBP3
FKBP4
FKBP5
FKBP5
FKBP5
FKBP5
FKBP8
FKBP8
FLI1
FLII
FLNB
FLNB
FLNB
FLNB
FLNB
FLNB
FLOT2
FLT3LG
FLVCR1
FLVCR1
FMNL1
FMNL3
FN3KRP
FN3KRP
FNBP1
FNBP1
FNBP1
FNBP1
FNBP1
FNBP4
FNDC3A
FNDC3A
FNTB
FNTB
FNTB
FOXJ3
FOXJ3
FOXJ3
FOXJ3
FOXJ3
FOXJ3
FOXK2
FOXK2
FOXM1
FOXM1
FOXM1
FOXM1
FOXRED1
FOXRED2
FRMD4A
FRMD8
FRYL
FRYL
FRYL
FTHL16
FTHL16
FTHL16
FTHL16
FTL
FTL
FTO
FTSJ2
FTSJ2
FTSJ2
FUBP1
FUBP1
FUBP1
FUBP3
FUCA2
FUCA2
FUCA2
FUK
FUK
FUS
FUS
FUT11
FUT11
FUT11
FUT8
FUT8
FUT8
FUT8
FUZ
FUZ
FXC1
FXYD5
FYTTD1
GAA
GABARAP

coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
mixed
mixed
UTR3
UTR3
UTR3
UTR3
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
UTR5
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
mixed
coding_exon
coding_exon
mixed
UTR3
coding_exon
mixed
UTR3
UTR5
UTR3
UTR3
UTR3

ENST00000238256:QtoR;
ENST00000381715:VtoG;ENST00000381719:VtoG;ENST00000381724:VtoG;ENST00
ENST00000381715:KtoE;ENST00000381719:KtoE;ENST00000381724:KtoE;ENST000
ENST00000381715:AtoD;ENST00000381719:AtoD;ENST00000381724:AtoD;ENST00

ENST00000337746:TtoP;ENST00000357266:TtoP;

ENST00000222308:FtoV;ENST00000453489:FtoV;
ENST00000281428:WtoR;ENST00000344954:WtoR;
ENST00000295956:VtoA;ENST00000348383:VtoA;ENST00000357272:VtoA;ENST00

ENST00000366971:NtoI;

ENST00000263773:QtoR;
ENST00000337156:StoP;ENST00000398316:StoP;ENST00000492622:StoP;
ENST00000359118:PtoR;

ENST00000361346:*toQ;ENST00000361776:*toQ;ENST00000372571:*toQ;ENST00

ENST00000342628:AtoG;ENST00000359843:AtoG;ENST00000361953:AtoG;

ENST00000216187:*toC;ENST00000366463:*toC;ENST00000397223:*toC;ENST000
ENST00000317568:GtoE;ENST00000355991:GtoE;ENST00000416776:GtoE;

ENST00000370767:StoR;ENST00000370768:StoR;ENST00000394922:StoR;ENST000

ENST00000372841:PtoS;ENST00000394790:PtoS;
ENST00000372841:PtoQ;ENST00000394790:PtoQ;
ENST00000342677:TtoS;ENST00000358307:TtoS;ENST00000360689:TtoS;ENST0000
ENST00000342677:MtoI;ENST00000358307:MtoI;ENST00000360689:MtoI;ENST000

ENST00000313777:VtoA;ENST00000421740:VtoA;ENST00000445575:VtoA;

74

+
+
+
+
+
+

+
+
+
+

+
+

+
+
+
+
+

+
+

+
+
+

+
+
+
+
+
+
+
+
+
+
+

+
+
+
+

AtoG
TtoG
AtoG
CtoA
TtoC
GtoT
TtoC
TtoA
AtoG
AtoC
AtoC
AtoG
TtoA
TtoG
CtoA
TtoC
TtoA
TtoC
TtoC
AtoG
CtoA
GtoA
TtoC
AtoG
CtoA
AtoT
TtoC
TtoA
CtoA
AtoG
TtoG
TtoA
AtoC
TtoA
AtoC
CtoT
AtoG
TtoC
AtoG
CtoG
AtoG
TtoC
TtoC
AtoG
TtoG
TtoC
GtoA
TtoC
TtoA
TtoA
CtoG
AtoT
TtoG
AtoG
TtoA
AtoC
AtoG
GtoA
TtoC
TtoA
GtoT
GtoA
AtoG
AtoG
CtoG
TtoC
GtoT
AtoG
AtoG
TtoG
AtoG
CtoA
CtoA
CtoA
TtoC
GtoT
TtoC
TtoC
CtoA
TtoA
TtoC
AtoG
CtoT
CtoA
AtoG
AtoT
GtoC
TtoC
AtoG
TtoC
TtoC
TtoG
AtoT
TtoC
TtoG
AtoG

0.1
0.1176
0.2
0.1
0.1
0.1
0.1
0.3
0.1111
0.25
0.1429
0.1
0.1
0.1069
0.1905
0.1
0.1034
0.1
0.1
0.125
0.1
0.1
0.1
0.1111
0.1
0.1333
0.1
0.1
0.1
0.1
0.125
0.1136
0.1
0.1
0.125
0.1
0.1
0.1
0.1
0.1
0.1071
0.1
0.125
0.1667
0.1667
0.1
0.1
0.1
0.1
0.1
0.1111
0.1176
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1333
0.1429
0.1739
0.1042
0.1538
0.1818
0.1111
0.1163
0.1176
0.1333
0.1111
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.2
0.1429
0.1538
0.1667
0.1667
0.1
0.12
0.1
0.1
0.1
0.125
0.1
0.1667
0.1
0.1
0.125

0.1579
0.1333
0.3
0.1538
0.2
0.1429
0.1034
0.4286
0.2
0.3333
0.2
0.1
0.1
0.1333
0.3333
0.1176
0.1154
0.1538
0.1
0.6364
0.1
0.125
0.1
0.5
0.1
0.2
0.1579
0.2
0.2727
0.4118
0.1364
0.1207
0.1538
0.2105
0.1538
0.1463
0.1053
0.1429
0.1818
0.2778
0.1475
0.1
0.1818
0.375
0.1818
0.1333
0.1
0.1
0.1818
0.1
0.125
0.1176
0.1
0.125
0.1111
0.1
0.2
0.1429
0.1
0.1538
0.1667
0.6071
0.2075
0.1818
0.2857
0.2593
0.25
0.1667
0.1667
0.2308
0.1176
0.2143
0.1429
0.1667
0.1
0.1
0.1
0.1429
0.1
0.1538
0.6
0.2
0.3636
0.3
0.1905
0.129
0.125
0.1333
0.1
0.1538
0.4
0.1333
0.2
0.125
0.2
0.25

4
2
2
5
4
5
4
3
6
3
3
2
2
5
8
4
6
3
3
13
4
3
2
6
2
2
4
2
10
2
3
7
2
8
2
4
4
3
4
7
6
2
5
4
8
4
2
2
3
6
5
6
3
2
5
3
7
2
4
3
6
17
16
3
2
13
12
2
7
5
4
6
2
6
3
3
4
7
2
2
3
2
2
2
2
2
3
3
2
2
2
3
2
4
2
11

2
2
2
2
2
4
2
2
3
2
2
2
2
3
2
2
5
2
2
13
2
2
2
6
2
2
3
2
2
2
2
2
2
6
2
4
2
2
2
5
2
2
2
3
2
2
2
2
3
2
2
2
2
2
2
2
5
2
2
2
2
17
11
2
2
6
5
2
2
4
2
4
2
3
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
6

[19,20]
[16,17]
[11,20]
[10,14]
[10,11]
[10,19]
[10,29]
[10,15]
[10,20]
[10,12]
[10,28]
[10,10]
[10,10]
[290,385]
[12,21]
[10,17]
[18,45]
[10,13]
[10,10]
[11,48]
[10,10]
[10,24]
[10,10]
[10,38]
[10,10]
[10,15]
[10,19]
[10,10]
[10,11]
[10,17]
[16,22]
[44,59]
[13,20]
[10,51]
[13,16]
[23,60]
[10,19]
[10,14]
[10,11]
[10,20]
[28,61]
[10,10]
[11,16]
[12,16]
[11,13]
[10,15]
[10,10]
[10,10]
[10,11]
[10,10]
[17,18]
[17,17]
[10,20]
[10,16]
[10,10]
[10,10]
[10,22]
[14,20]
[10,11]
[13,15]
[12,14]
[20,125]
[29,77]
[11,13]
[11,29]
[54,119]
[23,48]
[12,17]
[12,15]
[13,24]
[10,17]
[14,20]
[10,14]
[10,16]
[10,20]
[10,10]
[10,10]
[10,14]
[10,10]
[10,13]
[10,12]
[10,22]
[11,13]
[10,12]
[12,21]
[10,31]
[25,32]
[10,15]
[10,10]
[13,20]
[10,16]
[10,15]
[12,15]
[10,16]
[10,10]
[12,25]

TableS10

chr16:74168887
chr1:67926378
chr2:38814513
chr2:38815148
chr18:31511712
chr18:31517384
chr18:31545500
chr18:31545544
chr18:31545584
chr5:153736135
chr5:153778719
chr5:153778884
chr1:228438406
chr1:228483302
chr12:50034334
chr4:174480854
chr4:174481274
chr11:11249317
chr9:34639049
chr19:1348171
chr11:62150937
chr11:62156790
chr12:6514890
chr12:6514895
chr12:6517797
chr12:6517798
chr12:6513943
chr9:127134641
chr9:127104865
chr9:127139325
chr9:127156766
chr9:127164908
chr9:127064055
chr7:30640033
chr21:33804022
chr21:33822510
chr21:33825667
chr21:33825060
chr17:9758817
chr16:88629588
chr7:91914836
chr19:19477832
chr1:152049316
chr1:152045625
chr1:152049179
chr9:35730327
chr9:35727914
chr9:35726931
chr9:35727042
chr3:81631067
chr3:81621953
chr10:104126876
chr10:104120171
chr10:104126887
chr10:104126878
chr22:36541161
chr2:108475622
chr19:12865307
chr15:38846951
chr12:119112547
chr12:119107046
chr12:119082091
chr12:119049991
chr16:19420836
chr12:54429900
chr10:5847737
chr10:5847749
chr5:154262883
chr5:74054006
chr5:74082187
chr6:13468461
chr6:13468510
chr6:13468511
chr2:69406727
chr16:23384195
chr16:23384198
chr16:23385008
chr16:23385452
chr16:23385454
chr16:23385456
chr17:70744778
chr17:70745215
chr8:64099047
chr8:64090565
chr17:31987202
chr17:32008719
chr17:32015899
chr1:233572485
chr7:100122592
chr2:233385345
chr20:25374611
chr20:25374845
chr16:84278676
chr16:56995921
chr16:56997245
chr8:41516668

GABARAPL2
GADD45A
GALM
GALM
GALNT1
GALNT1
GALNT1
GALNT1
GALNT1
GALNT10
GALNT10
GALNT10
GALNT2
GALNT2
GALNT6
GALNT7
GALNT7
GALNTL4
GALT
GAMT
GANAB
GANAB
GAPDH
GAPDH
GAPDH
GAPDH
GAPDH
GAPVD1
GAPVD1
GAPVD1
GAPVD1
GAPVD1
GAPVD1
GARS
GART
GART
GART
GART
GAS7
GAS8
GATAD1
GATAD2A
GATAD2B
GATAD2B
GATAD2B
GBA2
GBA2
GBA2
GBA2
GBE1
GBE1
GBF1
GBF1
GBF1
GBF1
GCAT
GCC2
GCDH
GCHFR
GCN1L1
GCN1L1
GCN1L1
GCN1L1
GDE1
GDF11
GDI2
GDI2
GEMIN5
GFM2
GFM2
GFOD1
GFOD1
GFOD1
GFPT1
GGA2
GGA2
GGA2
GGA2
GGA2
GGA2
GGA3
GGA3
GGH
GGH
GGNBP2
GGNBP2
GGNBP2
GGPS1
GIGYF1
GIGYF2
GINS1
GINS1
GINS2
GINS3
GINS3
GINS4

UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
mixed
mixed
UTR3
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR5
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR5
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
UTR3
coding_exon

ENST00000269195:StoR;

ENST00000297107:AtoG;ENST00000425427:AtoG;

ENST00000366672:VtoG;

ENST00000227756:StoP;
ENST00000378842:TtoM;ENST00000450095:TtoM;
ENST00000346178:TtoP;ENST00000356638:TtoP;

ENST00000265956:NtoK;ENST00000297933:NtoK;ENST00000312123:NtoK;ENST00
ENST00000265956:EtoA;ENST00000297933:EtoA;ENST00000312123:EtoA;ENST000

ENST00000381815:LtoP;ENST00000381831:LtoP;ENST00000381839:LtoP;
ENST00000361093:VtoE;ENST00000381815:VtoE;ENST00000381831:VtoE;ENST000
ENST00000361093:StoP;ENST00000381815:StoP;ENST00000381831:StoP;ENST000
ENST00000361093:CtoG;ENST00000381815:CtoG;ENST00000381831:CtoG;ENST00
ENST00000268699:QtoR;

ENST00000378094:ItoV;ENST00000378103:ItoV;
ENST00000378088:VtoA;ENST00000378094:VtoA;ENST00000378103:VtoA;

ENST00000264326:FtoL;ENST00000429644:FtoL;ENST00000489715:FtoL;
ENST00000369983:VtoF;
ENST00000369983:EtoV;
ENST00000369983:DtoE;
ENST00000248924:LtoP;ENST00000323205:LtoP;
ENST00000309863:QtoR;ENST00000409325:QtoR;

ENST00000300648:TtoP;
ENST00000300648:LtoR;

ENST00000285873:LtoP;
ENST00000296805:QtoR;ENST00000345239:QtoR;

ENST00000260118:KtoE;
ENST00000304718:LtoQ;ENST00000453197:LtoQ;
ENST00000304718:FtoV;ENST00000453197:FtoV;

ENST00000275732:FtoV;

ENST00000276533:LtoI;

75

+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+

+
+
+
+
+
+
+
+
+
+
+
+

+
+
+

+
+
+
+
+
+
+
+

+
+
+
+

+
+
+

+
+
+

TtoA
TtoC
TtoC
CtoA
TtoA
GtoA
CtoT
AtoG
GtoC
CtoG
TtoC
TtoA
TtoG
AtoC
TtoA
AtoT
AtoG
TtoC
CtoT
TtoG
AtoC
TtoG
TtoA
TtoG
CtoA
AtoG
CtoG
TtoA
AtoC
TtoA
AtoG
TtoC
CtoT
CtoA
TtoC
TtoA
TtoC
TtoG
AtoG
AtoG
CtoG
TtoC
TtoC
TtoC
TtoA
AtoG
TtoC
AtoT
AtoC
TtoC
TtoA
GtoT
AtoT
CtoG
CtoG
TtoC
AtoG
TtoG
AtoC
AtoC
TtoG
TtoC
AtoG
AtoG
TtoC
CtoT
CtoT
TtoC
AtoG
TtoC
TtoA
GtoT
GtoC
TtoA
TtoG
TtoG
TtoG
TtoA
AtoG
TtoC
CtoA
TtoA
AtoG
TtoC
TtoA
TtoG
TtoC
AtoG
TtoG
AtoG
AtoG
TtoA
CtoT
TtoC
TtoC
CtoA

0.1111
0.1111
0.1
0.1
0.1
0.1
0.2
0.3158
0.3571
0.1
0.1
0.1
0.1143
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1017
0.9655
0.6667
0.1434
0.2083
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1515
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1818
0.1053
0.12
0.1053
0.1176
0.1
0.1
0.1
0.1111
0.1176
0.1
0.125
0.1
0.1
0.1
0.1
0.1026
0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1667
0.1667
0.1429
0.1
0.1053
0.1
0.1111
0.1429
0.125
0.1
0.1
0.1333
0.1818
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111

0.1111
0.1333
0.1111
0.125
0.1
0.1333
0.2143
0.3571
0.5455
0.2
0.1034
0.1
0.1333
0.1562
0.1111
0.1
0.1
0.1176
0.1429
0.1111
0.1333
0.2083
1
0.9459
0.5973
0.7627
0.3
0.1429
0.2308
0.1818
0.1538
0.1
0.1
0.1667
0.1333
0.1154
0.1538
0.1538
0.125
0.1
0.1
0.1333
0.1053
0.1176
0.1
0.1
0.1429
0.1053
0.125
0.2857
0.2
0.2632
0.2308
0.2222
0.2632
0.125
0.1
0.3125
0.1364
0.1379
0.2
0.1429
0.1
0.1538
0.1
0.2941
0.1818
0.1765
0.1538
0.1
0.1333
0.25
0.1818
0.1
0.2308
0.2
0.1667
0.1818
0.1
0.2
0.1875
0.1429
0.1875
0.1667
0.2
0.1538
0.2
0.1818
0.1765
0.125
0.1111
0.2222
0.1111
0.1
0.1538
0.125

8
5
2
2
2
2
4
2
3
3
3
4
5
6
3
2
2
2
2
2
2
3
2
5
11
10
8
3
2
3
5
4
2
3
7
3
2
2
3
2
2
4
5
4
2
2
4
2
2
11
3
10
3
8
8
4
3
12
5
4
6
2
2
3
3
11
5
2
4
3
2
3
3
2
6
6
6
6
3
11
7
3
2
5
12
4
8
2
4
2
2
2
2
2
4
2

2
2
2
2
2
2
2
2
3
2
2
2
2
4
2
2
2
2
2
2
2
2
2
5
11
10
4
2
2
2
3
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
6
2
2
2
2
4
2
2
8
3
2
2
2
2
2
2
8
4
2
2
2
2
2
2
2
3
3
2
2
2
6
4
2
2
2
4
2
3
2
2
2
2
2
2
2
2
2

[18,19]
[15,18]
[10,18]
[10,24]
[10,10]
[10,15]
[10,14]
[14,19]
[10,14]
[10,10]
[20,29]
[10,10]
[15,36]
[10,33]
[10,18]
[10,10]
[10,10]
[10,17]
[10,14]
[10,10]
[17,108]
[49,62]
[10,29]
[10,37]
[89,300]
[24,168]
[20,79]
[10,14]
[10,13]
[10,11]
[10,13]
[10,10]
[10,10]
[33,36]
[10,15]
[18,27]
[10,13]
[10,13]
[10,16]
[10,10]
[10,10]
[15,19]
[10,20]
[11,17]
[10,10]
[20,20]
[10,14]
[10,19]
[10,16]
[13,31]
[11,16]
[19,19]
[13,25]
[18,19]
[14,19]
[10,16]
[10,10]
[16,38]
[22,27]
[17,29]
[10,10]
[14,32]
[10,20]
[10,13]
[10,10]
[17,50]
[39,79]
[13,17]
[10,13]
[10,22]
[10,15]
[10,13]
[10,11]
[10,10]
[10,19]
[11,18]
[12,12]
[11,14]
[10,10]
[10,20]
[16,20]
[14,27]
[14,16]
[12,16]
[10,15]
[10,13]
[10,21]
[11,11]
[10,18]
[10,16]
[10,18]
[10,10]
[10,18]
[10,10]
[10,13]
[18,24]

TableS10

chr8:41520002
chr8:41520110
chr8:41520695
chr19:14449627
chr12:108860631
chr12:108852268
chr12:108853128
chr17:40238153
chr3:33040789
chr7:8077235
chr7:8093891
chr7:8095043
chr9:6579230
chr9:130324877
chr9:130325908
chr16:73198103
chr16:73077308
chr12:74178926
chr17:609495
chr5:95178004
chr5:95177977
chr5:95177998
chr1:191332427
chr1:191332433
chr2:191503510
chr2:191507031
chr2:191507081
chr19:17551292
chr19:52940631
chr19:52940634
chr19:52952124
chr10:88803080
chr6:1906016
chr1:28913869
chr1:28916980
chr20:61699570
chr20:61690429
chr20:61690523
chr19:19605988
chr6:24883212
chr3:49733935
chr3:49733941
chr7:2735417
chr7:2736238
chr7:2737020
chr17:60444881
chr17:60439259
chr17:60439947
chr1:109936795
chr1:109937658
chr20:56919632
chr1:1708124
chr1:1708127
chr5:180597737
chr5:180598671
chr5:180598672
chr5:180596541
chr5:180596546
chr5:180603508
chr15:50205438
chr14:51504587
chr14:51504700
chr14:51504783
chr6:30630380
chr1:37806535
chr3:52696595
chr3:52703472
chr1:229467739
chr1:229480108
chr5:141362927
chr5:141361616
chr14:52318354
chr14:52313599
chr12:63396591
chr12:63393623
chr12:63394880
chr9:126714123
chr9:130059564
chr9:130059028
chr12:99074687
chr12:131882878
chr12:131882519
chr12:131864335
chr12:131855676
chr12:131858545
chr12:131858658
chr12:131858834
chr12:131859540
chr3:37343120
chr3:37340849
chr3:37342182
chr3:37344167
chr3:37343844
chr3:122894071
chr3:122892914
chr3:122896113

GINS4
GINS4
GINS4
GIPC1
GIT2
GIT2
GIT2
GJC1
GLB1
GLCCI1
GLCCI1
GLCCI1
GLDC
GLE1
GLE1
GLG1
GLG1
GLIPR1
GLOD4
GLRX
GLRX
GLRX
GLRX2
GLRX2
GLS
GLS
GLS
GLT25D1
GLTSCR2
GLTSCR2
GLTSCR2
GLUD1
GMDS
GMEB1
GMEB1
GMEB2
GMEB2
GMEB2
GMIP
GMNN
GMPPB
GMPPB
GNA12
GNA12
GNA12
GNA13
GNA13
GNA13
GNAI3
GNAI3
GNAS
GNB1
GNB1
GNB2L1
GNB2L1
GNB2L1
GNB2L1
GNB2L1
GNB2L1
GNB5
GNG2
GNG2
GNG2
GNL1
GNL2
GNL3
GNL3
GNPAT
GNPAT
GNPDA1
GNPDA1
GNPNAT1
GNPNAT1
GNS
GNS
GNS
GOLGA1
GOLGA2
GOLGA2
GOLGA2L1
GOLGA3
GOLGA3
GOLGA3
GOLGA3
GOLGA3
GOLGA3
GOLGA3
GOLGA3
GOLGA4
GOLGA4
GOLGA4
GOLGA4
GOLGA4
GOLGB1
GOLGB1
GOLGB1

UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
mixed
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
mixed
mixed
UTR3
UTR3
UTR5
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon
UTR3
mixed
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon

ENST00000338373:TtoN;ENST00000343646:TtoN;ENST00000354574:TtoN;ENST00

ENST00000223145:QtoK;ENST00000456919:QtoK;

ENST00000309971:HtoR;ENST00000372770:HtoR;
ENST00000309971:CtoG;ENST00000372770:CtoG;
ENST00000205061:WtoG;ENST00000422840:WtoG;ENST00000447066:WtoG;
ENST00000456650:LtoR;
ENST00000237858:TtoR;ENST00000379979:TtoR;ENST00000448201:TtoR;
ENST00000237858:QtoR;ENST00000379979:QtoR;ENST00000448201:QtoR;
ENST00000237858:LtoQ;ENST00000379979:LtoQ;ENST00000448201:LtoQ;
ENST00000367439:LtoR;ENST00000367440:LtoR;
ENST00000367439:LtoP;ENST00000367440:LtoP;
ENST00000320717:NtoD;ENST00000338435:NtoD;ENST00000409215:NtoD;ENST00

ENST00000252599:VtoA;ENST00000379714:VtoA;
ENST00000246802:MtoI;ENST00000446535:MtoI;

ENST00000277865:RtoM;
ENST00000380815:StoP;
ENST00000294409:DtoE;ENST00000361872:DtoE;ENST00000373816:DtoE;ENST000
ENST00000266068:NtoH;ENST00000370069:NtoH;ENST00000370077:NtoH;

ENST00000203556:RtoQ;ENST00000445806:RtoQ;

ENST00000261837:StoR;ENST00000358784:StoR;ENST00000396335:StoR;

ENST00000376602:VtoG;ENST00000376621:VtoG;ENST00000426875:VtoG;ENST00
ENST00000373062:GtoR;
ENST00000354540:QtoR;ENST00000394799:QtoR;ENST00000418458:QtoR;ENST00
ENST00000366647:NtoD;
ENST00000311337:StoT;ENST00000458112:StoT;

ENST00000373555:TtoS;
ENST00000342583:HtoR;ENST00000421699:HtoR;

ENST00000204726:VtoA;ENST00000450791:VtoA;ENST00000456883:VtoA;
ENST00000204726:StoP;ENST00000450791:StoP;ENST00000456883:StoP;
ENST00000204726:DtoN;ENST00000450791:DtoN;ENST00000456883:DtoN;

ENST00000273176:VtoD;ENST00000356847:VtoD;ENST00000361924:VtoD;ENST00
ENST00000273176:QtoR;ENST00000356847:QtoR;ENST00000361924:QtoR;ENST00
ENST00000273176:KtoN;ENST00000356847:KtoN;ENST00000361924:KtoN;ENST00
ENST00000273176:EtoG;ENST00000356847:EtoG;ENST00000361924:EtoG;ENST000
ENST00000340645:VtoA;ENST00000393667:VtoA;
ENST00000340645:LtoM;ENST00000393667:LtoM;
ENST00000340645:EtoK;ENST00000393667:EtoK;

76

+
+
+

+
+
+

+
+

+
+
+
+
+
+
+

+
+

+
+
+

+
+
+

+
+
+
+

+
+
+
+
+

AtoC
TtoA
AtoG
TtoC
CtoA
TtoC
GtoA
TtoC
AtoG
CtoA
TtoG
TtoA
GtoA
AtoG
TtoG
TtoG
AtoG
TtoG
AtoC
CtoG
AtoG
TtoA
TtoG
TtoC
AtoG
AtoG
TtoA
TtoC
GtoC
GtoT
CtoA
GtoT
TtoC
TtoA
AtoC
AtoC
CtoG
TtoG
GtoA
GtoA
GtoA
AtoG
TtoG
AtoC
TtoG
TtoC
TtoG
TtoA
CtoT
CtoA
TtoC
AtoG
GtoA
TtoG
TtoG
GtoA
TtoA
TtoC
CtoT
TtoA
AtoT
TtoG
AtoG
TtoG
GtoA
AtoG
TtoA
AtoG
TtoC
TtoA
AtoG
TtoC
GtoC
CtoA
TtoA
GtoA
AtoT
AtoG
TtoC
GtoA
TtoC
TtoC
GtoA
TtoG
GtoT
TtoG
AtoG
GtoC
TtoA
AtoG
AtoC
AtoG
TtoG
TtoC
CtoA
GtoA

0.1
0.1333
0.129
0.1
0.1
0.1
0.1
0.1
0.1
0.1282
0.2
0.1
0.2258
0.1111
0.1
0.1
0.55
0.1
0.1
0.125
0.1
0.1667
0.1
0.1
0.1
0.1667
0.1
0.1
0.125
0.1
0.1429
0.1429
0.1176
0.1
0.1
0.1
0.1
0.1
0.4167
0.125
0.1
0.1
0.1
0.1
0.125
0.1
0.1
0.1111
0.1538
0.1
0.1053
0.1
0.1
0.1377
0.1
0.1111
0.25
0.1061
0.1
0.1
0.1
0.1
0.1429
0.1
0.1
0.1
0.125
0.1034
0.1034
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1304
0.1333
0.1
0.1154
0.1
0.25
0.1
0.4583
0.1
0.1667
0.1
0.1
0.1
0.1
0.1
0.1
0.1538
0.1
0.1053

0.1667
0.1429
0.1765
0.1111
0.1
0.1
0.1
0.1053
0.1111
0.1667
0.2105
0.1333
0.5455
0.1515
0.1
0.1111
0.5909
0.1
0.1667
0.3
0.1538
0.3333
0.1111
0.125
0.1364
0.1667
0.1304
0.1667
0.25
0.125
0.1818
0.1667
0.1818
0.1111
0.1
0.1
0.1
0.1
0.439
0.3333
0.1
0.1053
0.1
0.125
0.1667
0.25
0.3077
0.1818
0.25
0.2
0.125
0.1875
0.1875
0.1973
0.625
0.3158
0.6
0.3882
0.1818
0.1
0.1
0.1
0.3
0.125
0.1111
0.1429
0.1333
0.1176
0.1053
0.1
0.1667
0.1429
0.1
0.1
0.1154
0.1
0.1818
0.1429
0.1818
0.1
0.2
0.1667
0.625
0.2
0.625
0.1
0.1818
0.1
0.1176
0.1
0.1111
0.1
0.2
0.1667
0.1
0.1081

2
5
9
3
2
2
3
2
2
4
2
4
3
6
3
2
2
4
3
10
7
7
3
5
4
3
2
2
3
5
3
2
3
4
2
3
2
3
2
2
5
2
2
3
3
8
6
5
6
3
4
11
7
6
15
13
10
17
5
2
2
2
3
6
2
9
9
4
9
4
2
2
2
2
3
3
2
2
3
2
3
7
2
3
2
2
2
2
5
4
2
3
4
3
2
4

2
2
3
2
2
2
2
2
2
3
2
2
3
2
2
2
2
2
2
3
2
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
3
4
2
2
2
2
5
3
2
11
11
10
8
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2

[10,12]
[14,15]
[17,31]
[10,18]
[10,10]
[10,10]
[10,10]
[10,19]
[10,18]
[12,39]
[10,19]
[10,32]
[11,31]
[27,33]
[10,10]
[10,19]
[40,44]
[10,10]
[10,12]
[10,24]
[10,14]
[15,21]
[10,10]
[10,16]
[22,30]
[12,18]
[21,24]
[10,12]
[16,16]
[10,32]
[11,21]
[12,14]
[11,17]
[18,20]
[10,10]
[10,10]
[10,10]
[10,10]
[41,84]
[15,16]
[10,10]
[10,19]
[10,10]
[24,30]
[12,16]
[10,12]
[10,20]
[11,18]
[12,13]
[10,10]
[16,19]
[15,30]
[16,30]
[845,1409]
[10,32]
[12,34]
[12,27]
[85,223]
[10,19]
[10,10]
[10,10]
[10,10]
[10,21]
[16,21]
[10,18]
[36,40]
[31,34]
[29,35]
[19,30]
[10,10]
[10,12]
[10,14]
[10,10]
[10,10]
[10,26]
[10,10]
[10,11]
[14,23]
[11,15]
[10,10]
[10,26]
[10,18]
[12,24]
[10,10]
[24,24]
[10,10]
[11,12]
[10,10]
[10,17]
[10,10]
[10,18]
[10,10]
[10,10]
[12,13]
[10,10]
[19,37]

TableS10

chr3:122869078
chr3:169229782
chr3:169229710
chr12:21551100
chr1:154014233
chr1:153993406
chr1:154020201
chr1:154020206
chr3:39114855
chr3:39113871
chr2:171531334
chr17:25871098
chr17:25876463
chr17:42371411
chr17:42372550
chr17:42373160
chr17:42373646
chr16:57298537
chr17:39833281
chr17:39833504
chr17:39833495
chr17:39830321
chr5:56578661
chr5:56578781
chr1:45866141
chr1:45898920
chr1:45899369
chr2:157136035
chr14:66705421
chr19:39583074
chr19:39583075
chr2:27727152
chr9:131902750
chr9:131885669
chr19:6685248
chr16:56168144
chr1:234409911
chr3:99734681
chr3:171285142
chr3:171284558
chr3:128776733
chr3:128774647
chr13:94062525
chr2:231481135
chr16:45501197
chr16:45515940
chr3:49369614
chr3:49369615
chr3:49369616
chr19:40209205
chr17:70826870
chr9:37426949
chr10:121130427
chr5:176791614
chr19:52195609
chr19:52184656
chr19:52114246
chr19:52196128
chr19:52198012
chr4:71904392
chr19:53647788
chr19:53648960
chr19:53648966
chr3:121024141
chr3:121027474
chr3:121027634
chr16:11889042
chr16:11896341
chr16:11874069
chr8:30655761
chr4:106859965
chr1:110005385
chr11:67110698
chr14:76867621
chr14:80721638
chr14:80721637
chr15:57721658
chr15:57718394
chr1:89091326
chr3:121982892
chr3:121982782
chr8:30630513
chr8:30584177
chr8:30555647
chr13:44755819
chr11:18319431
chr11:18330044
chr12:122706323
chr13:26907824
chr16:27421714
chr16:27425741
chr16:27456649
chr16:27380264
chr16:27456740
chr2:197337450
chr9:134554475

GOLGB1
GOLIM4
GOLIM4
GOLT1B
GON4L
GON4L
GON4L
GON4L
GORASP1
GORASP1
GORASP2
GOSR1
GOSR1
GOSR2
GOSR2
GOSR2
GOSR2
GOT2
GPATCH8
GPATCH8
GPATCH8
GPATCH8
GPBP1
GPBP1
GPBP1L1
GPBP1L1
GPBP1L1
GPD2
GPHN
GPI
GPI
GPN1
GPR107
GPR107
GPR108
GPR114
GPR137B
GPR15
GPR160
GPR160
GPR175
GPR175
GPR180
GPR55
GPT2
GPT2
GPX1
GPX1
GPX1
GRAMD1A
GRB2
GRHPR
GRK5
GRK6
GRLF1
GRLF1
GRLF1
GRLF1
GRLF1
GRSF1
GRWD1
GRWD1
GRWD1
GSK3B
GSK3B
GSK3B
GSPT1
GSPT1
GSPT1
GSR
GSTCD
GSTM4
GSTP1
GSTZ1
GTF2A1
GTF2A1
GTF2A2
GTF2A2
GTF2B
GTF2E1
GTF2E1
GTF2E2
GTF2E2
GTF2E2
GTF2F2
GTF2H1
GTF2H1
GTF2H3
GTF3A
GTF3C1
GTF3C1
GTF3C1
GTF3C1
GTF3C1
GTF3C3
GTF3C4

coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
mixed
mixed
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR5
UTR5
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
mixed
mixed
coding_exon
mixed
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
mixed
mixed
coding_exon
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3

ENST00000309027:QtoR;ENST00000470487:QtoR;
ENST00000309027:EtoG;ENST00000470487:EtoG;
ENST00000229314:LtoV;
ENST00000271883:FtoC;ENST00000361040:FtoC;ENST00000368327:FtoC;ENST000

ENST00000319283:DtoA;ENST00000422110:DtoA;ENST00000479927:DtoA;

ENST00000335500:StoP;
ENST00000335500:DtoE;

ENST00000310454:DtoE;ENST00000409674:DtoE;ENST00000438166:DtoE;
ENST00000305960:VtoG;ENST00000315266:VtoG;ENST00000478722:VtoG;

ENST00000347136:StoP;ENST00000372406:StoP;ENST00000372410:StoP;ENST000

ENST00000366591:VtoA;ENST00000366592:VtoA;
ENST00000355897:StoT;
ENST00000355897:KtoR;
ENST00000355552:LtoP;ENST00000450633:LtoP;ENST00000489960:LtoP;
ENST00000376958:KtoE;
ENST00000340124:LtoP;ENST00000440783:LtoP;
ENST00000340124:AtoS;ENST00000440783:AtoS;

ENST00000355472:HtoP;ENST00000355958:HtoP;ENST00000393576:HtoP;
ENST00000317082:TtoP;ENST00000404338:TtoP;
ENST00000317082:LtoP;ENST00000404338:LtoP;

ENST00000298173:QtoR;ENST00000344860:QtoR;ENST00000393604:QtoR;ENST00
ENST00000396060:DtoE;ENST00000396061:DtoE;ENST00000396063:DtoE;ENST000

ENST00000283875:PtoQ;
ENST00000355904:StoP;

ENST00000228955:QtoL;
ENST00000170629:VtoA;ENST00000356183:VtoA;
ENST00000170629:StoP;ENST00000356183:StoP;
ENST00000170629:QtoK;ENST00000356183:QtoK;
ENST00000170629:MtoV;ENST00000356183:MtoV;

77

+
+
+
+
+
+
+

+
+

+
+
+
+
+
+
+

+
+
+
+
+

+
+

+
+
+
+
+
+
+
+

+
+
+

+
+
+
+

+
+

+
+
+
+
+

AtoG
AtoG
AtoG
TtoG
TtoG
GtoA
CtoT
AtoG
AtoC
AtoT
TtoC
AtoG
AtoG
GtoT
TtoC
GtoA
GtoT
AtoG
TtoC
TtoG
TtoC
GtoA
TtoC
TtoA
AtoG
TtoG
TtoG
TtoA
TtoG
GtoA
GtoA
AtoG
TtoC
TtoC
TtoC
AtoG
TtoC
TtoC
TtoA
AtoG
TtoC
TtoC
AtoG
AtoC
TtoC
GtoT
AtoG
GtoA
AtoG
TtoC
GtoC
AtoG
GtoA
AtoC
AtoC
TtoC
TtoC
TtoC
TtoC
TtoG
AtoC
AtoG
CtoA
TtoA
TtoG
AtoT
TtoC
TtoC
AtoG
TtoA
AtoG
TtoC
CtoA
TtoG
AtoG
AtoG
TtoA
TtoA
TtoC
CtoA
TtoC
TtoC
TtoC
TtoA
TtoC
GtoA
AtoG
AtoT
AtoG
TtoC
TtoC
CtoA
AtoG
TtoC
TtoC
TtoC

0.1
0.1
0.1176
0.1
0.1
0.1
0.2
0.8
0.1
0.1
0.1034
0.1
0.1176
0.125
0.1
0.1
0.1
0.1818
0.1
0.1
0.1
0.1
0.125
0.1333
0.1053
0.1
0.1
0.1
0.1176
0.1031
0.175
0.1053
0.1
0.1
0.1
0.1111
0.2
0.1389
0.1
0.1
0.1
0.2
0.1
0.1111
0.1
0.1
0.1
0.1034
0.1333
0.1111
0.125
0.102
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.1053
0.1538
0.1053
0.1
0.1818
0.1
0.3
0.1333
0.1
0.1
0.1154
0.1429
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1071
0.1
0.1
0.1
0.1
0.1
0.1
0.1

0.1111
0.1
0.1429
0.1
0.1
0.125
1
1
0.1
0.1
0.1081
0.1
0.1538
0.1333
0.1818
0.1818
0.1
0.5
0.1429
0.1429
0.1111
0.1333
0.1429
0.1765
0.15
0.1333
0.1
0.1538
0.2727
0.5385
0.4167
0.1818
0.1
0.1429
0.2
0.1111
0.2308
0.2308
0.2
0.2
0.1333
0.3636
0.1
0.375
0.125
0.1
0.2727
0.45
0.1633
0.1579
0.1333
0.16
0.1
0.1111
0.1
0.125
0.1
0.1667
0.1
0.1
0.2727
0.1
0.1818
0.1053
0.1
0.1
0.1176
0.16
0.2308
0.1
0.2
0.2143
0.375
0.1429
0.1818
0.1
0.122
0.1538
0.1
0.1
0.1
0.1364
0.1071
0.1818
0.125
0.1
0.1538
0.1
0.125
0.1176
0.2667
0.1818
0.1176
0.1
0.125
0.1111

3
3
5
3
2
3
7
6
2
2
8
3
6
3
3
3
2
10
5
2
2
3
3
5
8
2
4
6
6
12
3
4
2
2
3
4
7
5
2
4
5
3
2
2
2
2
7
21
9
5
2
8
3
4
2
2
2
4
3
2
3
4
2
4
3
2
3
2
6
4
3
8
5
2
4
2
12
4
2
2
2
9
9
3
4
2
4
2
7
5
6
2
2
4
4
3

2
2
2
2
2
3
7
6
2
2
3
2
3
2
2
2
2
10
2
2
2
2
2
2
3
2
2
3
4
12
3
2
2
2
2
2
2
2
2
2
3
3
2
2
2
2
4
20
2
4
2
5
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
5
2
2
4
4
2
2
2
3
2
2
2
2
2
3
2
3
2
2
2
2
3
4
2
2
3
3
3

[10,18]
[10,10]
[14,17]
[10,10]
[10,10]
[10,16]
[10,18]
[11,17]
[10,10]
[10,11]
[31,66]
[10,10]
[13,18]
[15,16]
[10,11]
[10,11]
[10,10]
[10,17]
[10,14]
[10,14]
[18,20]
[10,15]
[14,16]
[15,17]
[19,44]
[10,15]
[10,10]
[10,13]
[10,20]
[11,97]
[10,43]
[11,19]
[10,10]
[10,14]
[10,10]
[18,18]
[10,14]
[13,36]
[10,10]
[10,15]
[10,18]
[10,11]
[10,10]
[16,27]
[10,16]
[10,10]
[10,19]
[10,59]
[30,49]
[18,44]
[15,16]
[16,49]
[10,10]
[18,20]
[10,10]
[20,24]
[10,10]
[12,20]
[10,10]
[10,10]
[11,15]
[10,20]
[10,11]
[10,19]
[10,10]
[10,10]
[17,19]
[13,25]
[13,19]
[10,10]
[11,15]
[10,24]
[16,40]
[14,15]
[10,11]
[10,10]
[27,41]
[13,14]
[10,10]
[10,10]
[10,10]
[22,41]
[10,30]
[11,18]
[10,32]
[10,20]
[10,13]
[10,10]
[16,30]
[10,20]
[10,15]
[10,11]
[10,17]
[10,10]
[10,18]
[10,10]

TableS10

chr22:37460688
chr22:37456912
chr22:37459510
chr7:89850285
chr6:43701524
chr20:60209624
chr4:44395360
chr1:226400802
chr7:65077126
chr7:65077124
chr7:65063129
chr7:65063163
chr3:150227287
chr19:54163232
chr19:54163233
chr3:130517721
chr3:130516318
chr11:118470178
chr11:118470179
chr4:101088268
chr4:101088269
chr1:224326297
chr17:71287342
chr1:9250614
chr1:9251839
chr1:9251877
chr1:9252649
chr4:109175085
chr4:109175351
chr2:26267242
chr2:26267247
chr16:1799247
chr16:721569
chr5:140033675
chr5:140057813
chr5:140057359
chr14:22485495
chr7:106610216
chr6:135348187
chr16:3012638
chr6:30370460
chr3:122835810
chr3:122832993
chr3:122832994
chr3:122832999
chr1:31868059
chr1:32571292
chr22:49028251
chr6:114368807
chr6:114368903
chr17:39526713
chr17:39550389
chr17:39550391
chr12:46464259
chr18:42914887
chr1:234787129
chr2:37084285
chr2:37101336
chr2:37083208
chr2:37100470
chr17:55476186
chr8:145327325
chr6:138775736
chr14:30668402
chr14:30668403
chr14:30645615
chr3:126170402
chr10:96338107
chr10:96343310
chr10:96351316
chr15:61727398
chr15:61724913
chr15:61742256
chr15:61753662
chr15:61741103
chr15:61745401
chr15:61792844
chr4:89644413
chr15:70427100
chr17:77986962
chr8:80839339
chr8:43175441
chr8:43175591
chr9:96261903
chr9:96262498
chr7:27655708
chr7:27532390
chr7:27531806
chr2:190773385
chr14:61277022
chr14:61277024
chr5:175749358
chr5:175748374
chr5:175748375
chr11:118507795
chr5:130522885

GTPBP1
GTPBP1
GTPBP1
GTPBP10
GTPBP2
GTPBP5
GUF1
GUK1
GUSB
GUSB
GUSB
GUSB
GYG1
GYS1
GYS1
H1FX
H1FX
H2AFX
H2AFX
H2AFZ
H2AFZ
H3F3A
H3F3B
H6PD
H6PD
H6PD
H6PD
HADH
HADH
HADHA
HADHA
HAGH
HAGHL
HARS
HARS2
HARS2
HAUS4
HBP1
HBS1L
HCFC1R1
HCG18
HCLS1
HCLS1
HCLS1
HCLS1
HCRTR1
HDAC1
HDAC10
HDAC2
HDAC2
HDAC5
HDAC5
HDAC5
HDAC7
HDHD2
HEATR1
HEATR5B
HEATR5B
HEATR5B
HEATR5B
HEATR6
HEATR7A
HEBP2
HECTD1
HECTD1
HECTD1
HEG1
HELLS
HELLS
HELLS
HERC1
HERC1
HERC1
HERC1
HERC1
HERC1
HERC1
HERC5
HEXA
HEXDC
HEY1
HGSNAT
HGSNAT
HIATL1
HIATL1
HIBADH
HIBADH
HIBADH
HIBCH
HIF1A
HIF1A
HIGD2A
HIGD2A
HIGD2A
HINFP
HINT1

coding_exon
mixed
mixed
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
mixed
UTR3
UTR3
coding_exon
UTR3
mixed
mixed
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
mixed
mixed
UTR3
UTR3
UTR3
coding_exon
UTR3
mixed
UTR3
UTR3
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
coding_exon
coding_exon
mixed
UTR3
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
mixed
coding_exon
coding_exon
UTR3
UTR5
UTR5
coding_exon
UTR3

ENST00000222511:QtoR;ENST00000257659:QtoR;

ENST00000281543:Qto*;
ENST00000304895:ItoV;ENST00000345660:ItoV;ENST00000421103:ItoV;
ENST00000304895:ItoM;ENST00000345660:ItoM;ENST00000421103:ItoM;

ENST00000230771:VtoD;ENST00000412045:VtoD;ENST00000419246:VtoD;ENST00
ENST00000230771:TtoP;ENST00000412045:TtoP;ENST00000419246:TtoP;ENST000
ENST00000222574:LtoR;ENST00000417005:LtoR;ENST00000468410:LtoR;ENST000
ENST00000367837:StoP;ENST00000415177:StoP;

ENST00000080059:WtoR;ENST00000310824:WtoR;ENST00000354334:WtoR;ENST0
ENST00000366581:ItoV;ENST00000366582:ItoV;
ENST00000233099:WtoR;ENST00000354531:WtoR;
ENST00000233099:PtoQ;ENST00000354531:PtoQ;
ENST00000233099:MtoL;
ENST00000233099:AtoS;ENST00000354531:AtoS;

ENST00000058691:QtoR;ENST00000367697:KtoE;ENST00000448741:KtoE;
ENST00000261312:WtoS;ENST00000399332:WtoS;
ENST00000261312:WtoR;ENST00000399332:WtoR;

ENST00000261887:YtoH;ENST00000443617:YtoH;
ENST00000261887:WtoR;ENST00000443617:WtoR;
ENST00000261887:VtoL;ENST00000443617:VtoL;
ENST00000261887:QtoR;ENST00000443617:QtoR;

ENST00000264350:YtoN;
ENST00000327949:KtoQ;ENST00000337014:KtoQ;

ENST00000265395:MtoT;
ENST00000265395:FtoL;

ENST00000323441:VtoA;ENST00000337138:VtoA;ENST00000394997:VtoA;
ENST00000323441:NtoD;ENST00000337138:NtoD;ENST00000394997:NtoD;

ENST00000350777:LtoP;ENST00000437496:LtoP;

78

+
+
+
+

+
+
+

+
+
+
+
+
+

+
+

+
+

+
+

+
+
+

+
+
+
+

+
+
+
+
+
+

TtoC
TtoC
AtoC
AtoG
AtoG
GtoA
CtoT
TtoA
AtoG
CtoG
TtoC
AtoG
TtoG
GtoA
AtoC
GtoA
CtoA
TtoA
CtoG
AtoG
AtoG
AtoG
TtoC
AtoG
TtoG
GtoA
AtoG
AtoG
CtoA
AtoG
TtoC
TtoG
AtoT
GtoA
TtoA
AtoC
TtoC
TtoG
TtoC
TtoC
TtoA
AtoC
AtoG
AtoT
AtoC
AtoG
AtoG
GtoC
AtoG
TtoC
TtoC
GtoA
TtoG
TtoC
TtoC
AtoG
TtoC
CtoA
AtoC
GtoT
TtoC
GtoT
AtoG
GtoC
TtoA
TtoG
TtoG
TtoC
TtoC
AtoG
TtoC
TtoC
GtoC
AtoG
TtoG
TtoC
AtoG
TtoA
TtoG
AtoC
TtoA
TtoC
AtoT
AtoG
TtoC
TtoC
TtoC
TtoC
TtoA
TtoC
AtoG
CtoA
AtoT
CtoT
TtoC
CtoA

0.1
0.1
0.1111
0.1
0.1
0.1667
0.1
0.1
0.1176
0.1
0.1
0.1053
0.1053
0.1111
0.1111
0.3333
0.1667
0.1143
0.1053
0.1
0.1
0.125
0.1304
0.1
0.1
0.1
0.1
0.1111
0.1333
0.1053
0.1
0.1
0.1
0.1
0.1
0.1111
0.1373
0.1
0.1053
0.1
0.1053
0.1443
0.1039
0.1
0.1
0.1
0.1
0.1176
0.1
0.1111
0.2
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.2
0.2
0.1
0.1
0.1
0.1111
0.1
0.1
0.1176
0.1053
0.1
0.1176
0.1
0.1
0.1875
0.1
0.1
0.1
0.1
0.1053
0.129
0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.125
0.1
0.1429

0.1
0.1176
0.1538
0.1
0.1
0.1818
0.1
0.1
0.1818
0.1538
0.1176
0.125
0.1053
0.1364
0.1667
0.4654
0.1818
0.2333
0.2857
0.2143
0.1304
0.1429
0.2778
0.2
0.1
0.2308
0.1053
0.129
0.1765
0.1176
0.1591
0.1
0.1333
0.1538
0.1429
0.1667
0.1818
0.1
0.1333
0.2857
0.1429
0.16
0.6071
0.5957
0.2143
0.2
0.125
0.1333
0.125
0.1538
0.2
0.3333
0.1
0.1429
0.1333
0.1667
0.1
0.1
0.1
0.1
0.2
0.1429
0.1667
0.2727
0.3636
0.1
0.1
0.1667
0.1111
0.1429
0.1
0.1818
0.1818
0.1
0.1765
0.1333
0.1
0.2
0.1282
0.1111
0.1667
0.125
0.1176
0.1538
0.1765
0.1
0.1
0.1
0.1667
0.1333
0.1333
0.6
0.1818
0.1333
0.1
0.2857

2
7
2
3
4
2
2
2
5
4
6
8
2
8
4
2
2
9
16
5
7
6
4
2
3
2
3
9
2
5
7
6
5
7
5
3
4
2
5
14
2
9
15
17
11
3
5
4
3
9
4
5
4
3
3
5
2
3
2
2
2
3
5
2
3
5
3
2
2
3
2
2
7
3
4
2
2
3
7
2
3
2
2
5
2
3
4
3
2
3
5
4
5
6
5
6

2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
7
9
2
2
2
2
2
2
2
2
2
2
2
5
2
2
3
2
2
2
2
2
8
2
2
12
15
7
2
2
2
2
3
2
3
2
2
2
3
2
2
2
2
2
2
2
2
3
2
2
2
2
3
2
2
3
2
3
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
3

[10,10]
[17,20]
[10,14]
[10,10]
[10,11]
[11,12]
[10,10]
[10,10]
[11,17]
[10,13]
[10,17]
[16,20]
[19,19]
[19,22]
[18,18]
[55,160]
[12,22]
[16,61]
[19,67]
[10,14]
[10,23]
[14,16]
[23,36]
[10,10]
[10,10]
[10,13]
[10,19]
[27,31]
[31,34]
[17,20]
[10,44]
[10,30]
[10,15]
[10,19]
[10,15]
[18,18]
[22,51]
[10,10]
[15,19]
[12,45]
[14,19]
[97,125]
[13,77]
[15,67]
[22,70]
[10,10]
[16,20]
[15,17]
[10,16]
[13,29]
[10,10]
[10,17]
[10,10]
[10,15]
[15,20]
[12,20]
[10,10]
[10,10]
[10,10]
[10,10]
[10,10]
[10,14]
[10,24]
[10,11]
[11,11]
[10,10]
[10,10]
[10,12]
[18,37]
[10,15]
[10,10]
[11,17]
[11,19]
[10,10]
[14,17]
[10,15]
[10,10]
[10,16]
[31,39]
[10,10]
[10,12]
[10,16]
[17,19]
[13,31]
[17,18]
[10,10]
[10,10]
[10,20]
[10,12]
[10,15]
[10,15]
[10,16]
[15,22]
[15,24]
[10,10]
[12,14]

TableS10

chr9:35802964
chr1:114319824
chr7:139062552
chr7:138949714
chr7:138902088
chr7:138902248
chr11:33265575
chr11:33335107
chr6:26164406
chr6:26246261
chr6:26212488
chr6:26313114
chr6:12271726
chr1:41822998
chr10:70773697
chr10:70831169
chr10:70831629
chr10:70831630
chr2:74954504
chr6:31432278
chr6:31432274
chr6:31431286
chr6:31431284
chr6:31432015
chr6:31431241
chr6:31431283
chr6:31431282
chr6:31431233
chr6:31432056
chr6:31429628
chr6:31429630
chr6:31429631
chr6:31429634
chr6:31429636
chr6:31429637
chr6:31429638
chr6:31429643
chr6:31429665
chr6:31429782
chr6:31429972
chr6:31432920
chr6:31345285
chr6:31345287
chr6:31346177
chr6:31347755
chr6:31345298
chr6:31344507
chr6:31344508
chr6:31344509
chr6:31344511
chr6:31344520
chr6:31344701
chr6:31344751
chr6:31344805
chr6:33024526
chr6:33028847
chr6:33028848
chr6:33028849
chr6:33024389
chr6:33010392
chr6:33010396
chr6:33079973
chr6:33081833
chr6:33081964
chr6:33160714
chr6:33160936
chr6:33156435
chr6:33156606
chr6:33156577
chr6:33159732
chr6:33160721
chr6:33160928
chr6:33162303
chr6:33162309
chr6:33162523
chr6:33162525
chr6:33162713
chr6:32718368
chr6:32717985
chr6:32717704
chr6:32718513
chr6:32718773
chr6:32718997
chr6:32719177
chr6:32820977
chr6:32821022
chr6:32821707
chr6:32822142
chr6:32822009
chr6:32817258
chr6:32820969
chr6:32821026
chr6:32821805
chr6:32822011
chr6:32822053
chr6:32822146

HINT2
HIPK1
HIPK2
HIPK2
HIPK2
HIPK2
HIPK3
HIPK3
HIST1H1C
HIST1H2AC
HIST1H4C
HIST1H4E
HIVEP1
HIVEP3
HK1
HK1
HK1
HK1
HK2
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAB
HLAC
HLAC
HLAC
HLAC
HLAC
HLAC
HLAC
HLAC
HLAC
HLAC
HLAC
HLAC
HLAC
HLADMA
HLADMA
HLADMA
HLADMA
HLADMB
HLADMB
HLADMB
HLADOA
HLADOA
HLADOA
HLADPB1
HLADPB1
HLADPB1
HLADPB1
HLADPB1
HLADPB1
HLADPB1
HLADPB1
HLADPB1
HLADPB1
HLADPB1
HLADPB1
HLADPB1
HLADQA1
HLADQA1
HLADQA1
HLADQA1
HLADQA1
HLADQA1
HLADQA1
HLADQA2
HLADQA2
HLADQA2
HLADQA2
HLADQA2
HLADQA2
HLADQA2
HLADQA2
HLADQA2
HLADQA2
HLADQA2
HLADQA2

UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
mixed
mixed
mixed
mixed
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR5
UTR5
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon

ENST00000263551:DtoE;ENST00000342645:DtoE;ENST00000406875:DtoE;ENST000

ENST00000303296:StoP;ENST00000379016:StoP;ENST00000456517:StoP;

ENST00000290573:VtoG;ENST00000409174:VtoG;
ENST00000428231:QtoR;
ENST00000428231:LtoF;
ENST00000412585:WtoR;ENST00000428231:WtoR;
ENST00000412585:Wto*;ENST00000428231:Wto*;
ENST00000412585:VtoE;ENST00000428231:VtoE;
ENST00000412585:RtoW;ENST00000428231:RtoW;
ENST00000412585:AtoT;ENST00000428231:AtoT;
ENST00000412585:AtoD;ENST00000428231:AtoD;

ENST00000383329:TtoS;
ENST00000383329:PtoL;
ENST00000376228:Wto*;ENST00000383329:Wto*;ENST00000396254:Wto*;
ENST00000376228:CtoG;ENST00000383329:CtoG;ENST00000396254:CtoG;

ENST00000418931:RtoK;ENST00000422592:RtoK;
ENST00000411942:TtoI;ENST00000418931:TtoI;ENST00000422592:TtoI;
ENST00000411942:LtoV;ENST00000418931:LtoV;ENST00000422592:LtoV;
ENST00000411942:ItoL;ENST00000418931:ItoL;ENST00000422592:ItoL;
ENST00000411942:AtoD;ENST00000418931:AtoD;ENST00000422592:AtoD;

ENST00000343139:PtoL;ENST00000374949:PtoL;ENST00000395363:PtoL;ENST0000
ENST00000343139:DtoA;ENST00000374949:DtoA;ENST00000395363:DtoA;ENST00

ENST00000374940:TtoS;
ENST00000374940:TtoR;
ENST00000374940:StoP;
ENST00000374940:LtoP;
ENST00000374940:AtoT;

79

+
+

+
+
+
+

+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

TtoC
TtoC
TtoG
AtoC
TtoC
CtoT
TtoC
TtoC
AtoC
GtoA
TtoC
TtoG
TtoC
CtoA
AtoC
AtoG
TtoA
TtoG
TtoG
AtoG
GtoT
TtoC
GtoA
TtoA
CtoT
GtoA
CtoA
CtoG
CtoG
AtoG
GtoA
AtoG
TtoC
CtoA
CtoG
AtoT
TtoC
TtoG
CtoT
TtoG
GtoT
AtoT
CtoT
GtoA
TtoG
GtoA
GtoA
AtoG
CtoA
TtoC
TtoC
GtoA
CtoT
AtoC
GtoA
TtoC
TtoC
GtoT
TtoA
AtoG
TtoC
TtoA
TtoC
TtoC
GtoA
CtoT
CtoG
AtoC
CtoA
TtoA
TtoC
TtoC
GtoC
TtoC
AtoG
CtoA
CtoA
CtoT
AtoC
CtoT
AtoC
GtoC
AtoG
TtoA
CtoG
CtoG
TtoC
TtoC
GtoA
CtoT
CtoG
AtoG
CtoT
CtoA
GtoA
AtoG

0.1
0.1
0.1053
0.1
0.1154
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1667
0.1304
0.2
0.102
0.16
0.1
0.1325
0.8008
0.1234
0.16
0.1111
0.1071
0.9596
0.1127
0.1111
0.2174
0.1184
0.1522
0.1053
0.125
0.1163
0.1682
0.1489
0.1009
0.1975
0.25
0.15
0.1
0.1299
0.1111
0.25
0.1
0.1176
0.12
0.1111
0.151
0.1363
0.3576
0.1176
0.1
0.1
0.2
0.1818
0.1667
0.1111
0.1818
0.1111
0.1579
0.144
0.5155
0.1119
0.1143
0.1731
0.1
0.2517
0.5786
0.3666
0.2974
0.1
0.1
0.1
0.1515
0.1
0.25
0.1338
0.125
0.1
0.1754
0.994
0.9966
0.1
1
0.9845
1
0.9936
0.9545
1
0.9688
0.4184
1

0.2
0.1
0.1429
0.1
0.125
0.3
0.1111
0.2143
0.1775
0.1333
0.1923
0.1
0.1176
0.1
0.1111
0.127
0.4545
0.3333
0.4286
0.1667
0.3455
0.1475
0.625
0.922
0.1633
0.2667
0.155
0.1422
0.9745
0.2
0.5833
0.2667
0.3636
0.1818
0.1633
0.125
0.2283
0.2069
0.1707
0.125
0.2012
0.5588
0.5
0.15
0.1691
0.3846
0.3125
0.2
0.125
0.2857
0.2857
0.3262
0.1592
0.4191
0.1333
0.1111
0.1818
0.2
0.3846
0.2727
0.2727
0.2
0.1481
0.4545
0.1915
0.6195
0.1393
0.3487
0.4013
0.1818
0.2979
0.6254
0.3918
0.305
0.1915
0.2206
0.1176
0.3
0.125
0.25
0.492
0.2716
0.2647
0.4706
1
1
0.25
1
1
1
1
1
1
1
0.8305
1

9
3
5
2
6
7
3
3
12
3
4
2
3
2
7
4
8
7
4
5
7
6
6
3
3
4
3
4
2
3
5
7
7
6
4
7
10
5
3
8
2
6
7
2
2
3
3
3
4
6
11
2
6
2
6
6
6
3
9
4
13
2
2
6
3
2
3
2
3
4
2
2
2
2
22
16
2
4
7
2
5
3
7
3
3
5
3
3
5
2
3
5
2
5
2
3

5
2
2
2
2
2
3
2
7
2
4
2
2
2
2
2
6
4
2
3
7
3
6
2
2
3
2
2
2
2
5
4
6
3
3
2
6
2
2
2
2
4
5
2
2
3
2
2
2
5
5
2
3
2
2
2
3
2
6
2
6
2
2
3
3
2
3
2
2
2
2
2
2
2
15
8
2
2
4
2
5
2
6
3
3
5
2
3
5
2
3
5
2
5
2
3

[10,45]
[10,10]
[14,19]
[10,10]
[16,26]
[10,10]
[10,19]
[10,14]
[10,231]
[10,15]
[10,26]
[10,10]
[10,17]
[10,10]
[10,27]
[66,70]
[11,22]
[14,23]
[10,21]
[49,54]
[25,66]
[19,67]
[19,147]
[141,532]
[1049,2558]
[14,52]
[76,140]
[1672,4098]
[204,676]
[10,71]
[12,54]
[15,46]
[25,77]
[48,110]
[51,119]
[32,68]
[73,262]
[320,422]
[2443,3068]
[115,170]
[159,165]
[16,44]
[15,53]
[10,20]
[308,337]
[13,21]
[12,16]
[10,15]
[16,17]
[14,25]
[14,48]
[615,1151]
[1921,2632]
[1430,3239]
[15,17]
[10,18]
[10,22]
[10,11]
[11,54]
[12,23]
[11,18]
[10,23]
[27,27]
[11,19]
[113,705]
[259,1253]
[280,412]
[565,1928]
[209,2879]
[10,11]
[143,483]
[280,1198]
[486,974]
[436,850]
[30,156]
[30,93]
[10,17]
[10,33]
[10,27]
[12,24]
[412,1249]
[81,354]
[10,34]
[13,57]
[184,336]
[102,588]
[10,12]
[11,164]
[68,129]
[19,40]
[101,156]
[88,482]
[228,610]
[10,64]
[98,118]
[72,162]

TableS10

chr6:32822439
chr6:32735311
chr6:32735643
chr6:32735954
chr6:32833615
chr6:32833545
chr6:32833632
chr6:32833616
chr6:32833537
chr6:32834734
chr6:32834781
chr6:32837417
chr6:32837655
chr6:32834681
chr6:32834752
chr6:32833550
chr6:32833574
chr6:32834699
chr6:32834747
chr6:32834750
chr6:32837632
chr6:32520797
chr6:32515651
chr6:32657401
chr6:32660050
chr6:32656562
chr6:32654528
chr6:32654529
chr6:32654655
chr6:32595272
chr6:32628642
chr6:32628643
chr6:32628676
chr6:32628744
chr6:32628796
chr6:30565370
chr6:30569087
chr6:30569947
chr6:30569950
chr6:30565279
chr6:29801764
chr6:29802797
chr6:29800048
chr6:29802639
chr6:29802234
chr3:150231029
chr20:29621008
chr20:29621010
chr8:28965426
chr15:75537829
chr15:75563248
chr6:34321978
chr13:29935772
chr13:29934683
chr13:29935349
chr13:29935348
chr13:29935356
chr13:29935469
chr13:29935468
chr13:29934680
chr13:29934681
chr13:29934813
chr13:29935421
chr13:29931641
chr13:29931667
chr13:29938058
chr5:74691035
chr21:39642102
chr21:39642105
chr21:39642227
chr21:39642229
chr21:39636278
chr1:26673187
chr1:26673698
chr1:26673654
chr1:26673692
chr1:26673161
chr1:26674231
chr1:26674233
chr1:26674236
chr1:26674340
chr1:26674349
chr1:26674703
chr1:26674704
chr1:26674990
chr1:26674991
chr1:26675000
chr1:26675046
chr6:79967684
chr5:149384094
chr5:149411669
chr5:149412837
chr22:34020398
chr22:34021468
chr19:1036816
chr19:1037623

HLADQA2
HLADQB1
HLADQB1
HLADQB1
HLADQB2
HLADQB2
HLADQB2
HLADQB2
HLADQB2
HLADQB2
HLADQB2
HLADQB2
HLADQB2
HLADQB2
HLADQB2
HLADQB2
HLADQB2
HLADQB2
HLADQB2
HLADQB2
HLADQB2
HLADRA
HLADRA
HLADRB1
HLADRB1
HLADRB1
HLADRB1
HLADRB1
HLADRB1
HLADRB5
HLADRB6
HLADRB6
HLADRB6
HLADRB6
HLADRB6
HLAE
HLAE
HLAE
HLAE
HLAE
HLAF
HLAF
HLAF
HLAF
HLAF
HLTF
HM13
HM13
HMBOX1
HMG20A
HMG20A
HMGA1
HMGB1
HMGB1
HMGB1
HMGB1
HMGB1
HMGB1
HMGB1
HMGB1
HMGB1
HMGB1
HMGB1
HMGB1
HMGB1
HMGB1
HMGCR
HMGN1
HMGN1
HMGN1
HMGN1
HMGN1
HMGN2
HMGN2
HMGN2
HMGN2
HMGN2
HMGN2
HMGN2
HMGN2
HMGN2
HMGN2
HMGN2
HMGN2
HMGN2
HMGN2
HMGN2
HMGN2
HMGN3
HMGXB3
HMGXB3
HMGXB3
HMGXB4
HMGXB4
HMHA1
HMHA1

UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR5
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
mixed
mixed
mixed
coding_exon
UTR3
UTR3
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3

ENST00000435145:StoC;ENST00000437316:StoC;
ENST00000435145:RtoH;ENST00000437316:RtoH;
ENST00000435145:QtoP;ENST00000437316:QtoP;
ENST00000435145:QtoH;ENST00000437316:QtoH;
ENST00000435145:GtoS;ENST00000437316:GtoS;
ENST00000411527:StoP;ENST00000429950:StoP;ENST00000435145:StoP;ENST000
ENST00000411527:QtoR;ENST00000429950:QtoR;ENST00000435145:QtoR;ENST00
ENST00000411527:QtoR;ENST00000429950:QtoR;ENST00000435145:QtoR;ENST00
ENST00000411527:MtoL;ENST00000429950:MtoL;ENST00000435145:MtoL;ENST00
ENST00000411527:ItoM;ENST00000429950:ItoM;ENST00000435145:ItoM;ENST000
ENST00000411527:AtoT;ENST00000429950:AtoT;ENST00000435145:AtoT;ENST000

ENST00000360004:VtoA;
ENST00000360004:NtoH;

ENST00000374975:AtoT;

ENST00000376628:WtoG;

ENST00000440587:ItoT;
ENST00000259951:WtoG;ENST00000423522:WtoG;ENST00000440587:WtoG;ENST
ENST00000259951:RtoS;ENST00000334668:RtoS;ENST00000376861:RtoS;ENST000
ENST00000259951:AtoG;ENST00000399258:AtoG;ENST00000423522:AtoG;ENST00

ENST00000336216:TtoP;ENST00000381714:TtoP;

ENST00000326004:YtoN;ENST00000339872:YtoN;ENST00000341423:YtoN;ENST00
ENST00000326004:YtoD;ENST00000339872:YtoD;ENST00000341423:YtoD;ENST000
ENST00000326004:RtoS;ENST00000339872:RtoS;ENST00000341423:RtoS;ENST000
ENST00000326004:PtoS;ENST00000339872:PtoS;ENST00000341423:PtoS;ENST000
ENST00000326004:PtoL;ENST00000339872:PtoL;ENST00000341423:PtoL;ENST0000
ENST00000326004:KtoN;ENST00000339872:KtoN;ENST00000341423:KtoN;ENST00
ENST00000326004:Gto*;ENST00000339872:Gto*;ENST00000341423:Gto*;ENST00
ENST00000326004:EtoQ;ENST00000339872:EtoQ;ENST00000341423:EtoQ;ENST00

ENST00000380747:KtoE;ENST00000380748:KtoE;ENST00000380749:KtoE;
ENST00000380747:KtoE;ENST00000380748:KtoE;ENST00000380749:KtoE;

ENST00000361427:PtoT;
ENST00000361427:KtoE;
ENST00000361427:GtoA;
ENST00000361427:AtoT;

ENST00000421549:QtoR;

ENST00000313093:StoR;ENST00000412039:StoR;

80

+
+

+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+

TtoC
CtoT
TtoA
CtoT
AtoT
GtoA
AtoC
GtoC
GtoA
TtoC
AtoG
AtoG
AtoC
AtoG
GtoA
CtoT
GtoC
TtoC
TtoC
CtoT
AtoC
TtoC
TtoC
TtoC
AtoC
CtoA
TtoA
GtoA
AtoT
GtoA
CtoT
GtoT
AtoG
AtoC
CtoA
TtoG
TtoA
AtoG
AtoG
GtoT
TtoC
TtoG
CtoA
CtoG
AtoG
CtoA
GtoA
GtoA
AtoT
AtoC
TtoA
TtoA
TtoA
TtoG
GtoT
CtoT
CtoT
AtoC
GtoT
GtoC
CtoT
AtoG
AtoG
AtoG
AtoG
AtoG
TtoC
AtoG
AtoG
GtoA
CtoA
TtoG
CtoA
AtoG
GtoC
GtoA
AtoG
TtoC
TtoC
AtoG
AtoT
GtoT
GtoC
GtoT
AtoG
AtoG
AtoG
TtoC
AtoG
AtoG
CtoT
TtoA
TtoC
TtoA
TtoG
TtoC

0.9706
0.1282
0.102
0.3333
0.3
0.9375
0.1333
0.3182
0.9104
0.2727
1
0.9662
0.2143
0.1
0.375
0.3913
0.996
0.6774
0.9136
0.24
0.9595
0.1
0.1053
0.1333
0.2233
0.1075
0.3333
0.1224
0.4343
0.5682
0.9792
1
0.3497
0.306
0.24
0.1739
0.1
0.1111
0.1
0.1
0.2727
0.1
0.1618
0.2
0.1
0.1176
0.1053
0.1
0.1
0.1176
0.1111
0.1
0.1
0.1
0.1111
0.1
0.1
0.3333
0.3125
0.1176
0.1071
0.4444
0.1
0.1
0.1
0.1
0.1143
0.1429
0.125
0.1111
0.1304
0.1091
0.125
0.1364
0.1
0.1
0.1
0.1053
0.12
0.1
0.1176
0.1364
0.1579
0.1429
0.1333
0.1053
0.1053
0.1
0.1333
0.1
0.4545
0.1
0.1
0.1333
0.1333
0.1111

1
0.3913
0.3333
0.3478
0.3
1
0.2222
0.4545
1
1
1
1
0.5
0.1818
1
1
1
1
1
0.9286
1
0.2619
0.1429
0.1538
0.8222
0.4444
0.8
0.3469
0.6926
0.8997
1
1
0.7285
0.461
0.4545
0.3333
0.1111
0.1818
0.4286
0.1071
0.5455
0.3
0.3678
0.2308
0.2609
0.1176
0.2727
0.1
0.1
0.125
0.25
0.3
0.1111
0.2667
0.3333
0.1875
0.2
0.3636
0.5
0.2222
0.4706
0.5
0.1667
0.1
0.1
0.2
0.2667
0.2308
0.1429
0.1818
0.1765
0.125
0.25
0.1538
0.1333
0.125
0.1
0.15
0.4167
0.5
0.1724
0.4286
0.1765
0.1724
0.1429
0.1316
0.1562
0.1818
0.1818
0.1
0.5
0.1538
0.1176
0.1429
0.2308
0.1667

6
4
12
2
4
6
4
5
4
2
2
6
3
3
7
8
2
8
4
4
2
17
8
2
3
2
2
12
2
3
3
2
3
7
2
6
4
4
9
7
4
2
5
3
8
3
5
2
3
3
7
2
2
7
7
7
4
3
3
5
6
3
4
4
2
5
6
7
4
10
8
9
6
6
4
2
2
7
14
7
4
7
3
3
9
5
4
8
7
2
2
7
3
2
2
9

6
4
4
2
2
6
3
2
4
2
2
6
3
2
7
8
2
8
4
4
2
12
3
2
3
2
2
9
2
3
2
2
3
7
2
4
2
2
9
3
3
2
5
2
5
2
3
2
2
2
2
2
2
4
6
3
3
2
3
3
5
2
4
2
2
2
3
2
2
4
5
2
5
2
2
2
2
3
11
6
2
4
3
2
3
2
2
3
2
2
2
2
2
2
2
5

[23,114]
[13,39]
[16,49]
[92,96]
[10,21]
[10,88]
[15,18]
[11,22]
[25,95]
[11,11]
[23,129]
[34,553]
[10,14]
[10,11]
[16,131]
[15,115]
[191,251]
[13,31]
[29,81]
[11,125]
[42,74]
[44,150]
[14,19]
[27,50]
[262,1264]
[10,94]
[11,12]
[18,217]
[503,890]
[397,644]
[34,48]
[722,997]
[128,291]
[141,334]
[25,33]
[11,23]
[10,18]
[18,22]
[10,18]
[10,28]
[11,11]
[10,11]
[69,157]
[10,13]
[10,68]
[17,17]
[11,19]
[10,10]
[10,10]
[16,17]
[10,12]
[10,10]
[10,18]
[10,15]
[10,19]
[10,19]
[10,11]
[11,13]
[11,16]
[16,18]
[13,28]
[10,12]
[10,12]
[10,10]
[10,10]
[10,10]
[15,35]
[13,28]
[14,16]
[11,27]
[12,29]
[42,60]
[13,24]
[13,22]
[10,15]
[16,30]
[10,10]
[19,31]
[13,78]
[10,28]
[29,51]
[13,28]
[17,27]
[21,30]
[14,21]
[19,39]
[19,35]
[10,23]
[11,15]
[10,10]
[11,30]
[10,14]
[10,17]
[14,15]
[15,27]
[18,52]

TableS10

chr5:162851186
chr16:4499897
chr17:70643681
chr17:70643687
chr17:70643688
chr16:1689356
chr16:1689541
chr16:1691541
chr16:1691627
chr17:33167852
chr17:33167921
chr17:33167850
chr17:33167926
chr5:137115700
chr5:137116262
chr12:52961437
chr12:52960869
chr12:52962536
chr12:52963863
chr12:52962537
chr12:52962527
chr12:52962664
chr12:52960818
chr7:26196858
chr7:26196960
chr7:26197850
chr7:26198027
chr2:177790723
chr2:177789516
chr2:177789664
chr2:177790739
chr2:177789518
chr2:177789554
chr2:177789651
chr2:177789654
chr2:177790695
chr2:177790704
chr2:177790722
chr2:177790737
chr14:20771963
chr14:20750982
chr14:20750979
chr14:20750975
chr14:20750978
chr14:20750981
chr14:20771965
chr4:83494040
chr4:83494212
chr5:178974419
chr10:69767653
chr10:69767594
chr10:69767617
chr10:69771860
chr19:44028133
chr19:44021073
chr19:44026546
chr19:44028541
chr19:44021390
chr19:44028151
chr19:44020924
chr19:44026579
chr19:44026580
chr19:44026556
chr19:44026555
chr19:44020102
chr19:44021024
chr19:44026491
chr19:44029800
chr19:44019142
chr19:44019143
chr1:243085469
chr1:243085472
chr19:46492379
chr19:46505339
chr19:46505340
chr11:62238821
chr4:83566704
chr5:78704985
chr14:22815360
chr14:22814368
chr14:22814390
chr14:22814600
chr8:43001115
chr17:44009283
chr1:20943593
chr2:10484784
chr2:10485148
chr1:45566577
chr10:100185446
chr10:100192899
chr10:100167122
chr3:150341831
chr22:25190014
chr22:25207781
chr11:18269887
chr11:18257672

HMMR
HMOX2
HN1
HN1
HN1
HN1L
HN1L
HN1L
HN1L
HNF1B
HNF1B
HNF1B
HNF1B
HNRNPA0
HNRNPA0
HNRNPA1P2
HNRNPA1P2
HNRNPA1P2
HNRNPA1P2
HNRNPA1P2
HNRNPA1P2
HNRNPA1P2
HNRNPA1P2
HNRNPA2B1
HNRNPA2B1
HNRNPA2B1
HNRNPA2B1
HNRNPA3
HNRNPA3
HNRNPA3
HNRNPA3
HNRNPA3
HNRNPA3
HNRNPA3
HNRNPA3
HNRNPA3
HNRNPA3
HNRNPA3
HNRNPA3
HNRNPC
HNRNPC
HNRNPC
HNRNPC
HNRNPC
HNRNPC
HNRNPC
HNRNPD
HNRNPD
HNRNPH1
HNRNPH3
HNRNPH3
HNRNPH3
HNRNPH3
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPL
HNRNPU
HNRNPU
HNRNPUL1
HNRNPUL1
HNRNPUL1
HNRNPUL2
HNRPDL
HOMER1
HOMEZ
HOMEZ
HOMEZ
HOMEZ
HOOK3
HOXB3
HP1BP3
HPCAL1
HPCAL1
HPDL
HPS1
HPS1
HPS1
HPS3
HPS4
HPS4
HPS5
HPS5

UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR5
coding_exon
UTR3

ENST00000225893:PtoR;ENST00000427275:PtoR;
ENST00000225893:NtoS;ENST00000427275:NtoS;
ENST00000225893:EtoQ;ENST00000427275:EtoQ;

ENST00000330752:StoT;ENST00000340913:StoT;ENST00000420780:StoT;
ENST00000330752:Sto*;ENST00000340913:Sto*;ENST00000420780:Sto*;
ENST00000330752:RtoS;ENST00000340913:RtoS;ENST00000420780:RtoS;
ENST00000330752:GtoV;ENST00000340913:GtoV;
ENST00000330752:GtoC;ENST00000340913:GtoC;ENST00000420780:GtoC;

ENST00000392524:YtoH;ENST00000411529:YtoH;ENST00000416446:YtoH;ENST000
ENST00000392524:VtoG;ENST00000411529:VtoG;ENST00000412538:VtoG;ENST00
ENST00000392524:StoP;ENST00000411529:StoP;ENST00000412538:StoP;ENST000
ENST00000392524:PtoR;ENST00000411529:PtoR;ENST00000416446:PtoR;ENST000
ENST00000392524:KtoE;ENST00000411529:KtoE;ENST00000412538:KtoE;ENST000
ENST00000392524:GtoR;ENST00000411529:GtoR;ENST00000412538:GtoR;ENST00

ENST00000320084:GtoV;ENST00000336053:GtoV;ENST00000420743:GtoV;ENST00
ENST00000216296:RtoQ;ENST00000320084:RtoQ;ENST00000336053:RtoQ;ENST00
ENST00000216296:GtoE;ENST00000320084:GtoE;ENST00000336053:GtoE;ENST000

ENST00000265866:TtoP;ENST00000354695:TtoP;

ENST00000221419:VtoG;ENST00000388749:VtoG;ENST00000388750:VtoG;ENST00
ENST00000221419:StoF;ENST00000388749:StoF;ENST00000388750:StoF;
ENST00000221419:StoC;ENST00000388749:StoC;ENST00000388750:StoC;ENST000
ENST00000221419:QtoR;ENST00000388749:QtoR;ENST00000388750:QtoR;ENST00
ENST00000221419:QtoK;ENST00000388749:QtoK;ENST00000388750:QtoK;
ENST00000221419:NtoT;ENST00000388749:NtoT;ENST00000388750:NtoT;ENST00
ENST00000221419:HtoN;ENST00000388749:HtoN;ENST00000388750:HtoN;
ENST00000221419:DtoV;ENST00000388749:DtoV;ENST00000388750:DtoV;ENST00
ENST00000221419:DtoH;ENST00000388749:DtoH;ENST00000388750:DtoH;ENST00
ENST00000221419:AtoT;ENST00000388749:AtoT;ENST00000388750:AtoT;ENST000
ENST00000221419:AtoG;ENST00000388749:AtoG;ENST00000388750:AtoG;ENST00

ENST00000263367:NtoT;ENST00000352456:NtoT;ENST00000378215:NtoT;ENST00

ENST00000357460:LtoP;

ENST00000249092:KtoT;ENST00000325103:KtoT;ENST00000338546:KtoT;ENST000
ENST00000249092:FtoS;ENST00000325103:FtoS;ENST00000338546:FtoS;ENST0000
ENST00000296051:LtoP;ENST00000460120:LtoP;
ENST00000336873:RtoW;ENST00000398141:RtoW;ENST00000398145:RtoW;ENST0

81

+
+

+
+
+
+

+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+

+
+
+

+
+
+

TtoC
AtoG
TtoG
AtoG
GtoA
AtoC
TtoC
AtoG
GtoT
CtoG
AtoG
GtoC
AtoG
CtoT
AtoG
TtoA
CtoG
AtoC
GtoT
GtoT
CtoT
TtoG
GtoC
TtoC
TtoC
TtoA
TtoC
TtoC
TtoG
TtoC
CtoG
AtoG
GtoC
TtoC
TtoC
TtoG
TtoC
CtoG
AtoT
GtoT
GtoA
GtoA
TtoG
AtoG
GtoA
TtoC
TtoA
TtoC
TtoC
AtoC
AtoC
AtoG
TtoC
TtoG
CtoT
CtoG
AtoG
CtoA
AtoC
CtoA
AtoT
GtoC
GtoA
CtoG
AtoG
GtoA
AtoG
AtoG
TtoA
AtoG
AtoG
TtoG
AtoC
CtoA
TtoA
TtoA
AtoG
GtoT
TtoC
GtoA
TtoC
TtoG
AtoG
TtoG
TtoA
TtoC
TtoC
AtoG
AtoC
TtoC
AtoG
TtoC
AtoT
TtoA
AtoT
AtoG

0.1
0.1
0.1111
0.1034
0.1
0.1176
0.1489
0.1
0.1
0.1429
0.1111
0.1111
0.1154
0.1
0.1296
0.1053
0.1034
0.1159
0.1
0.1059
0.1
0.1088
0.1
0.1
0.1111
0.1304
0.125
0.1
0.15
0.1
0.1
0.1
0.1053
0.1143
0.1
0.1271
0.1034
0.1
0.1
0.122
0.1
0.1
0.1
0.122
0.1552
0.1053
0.1
0.1014
0.1148
0.1129
0.1
0.4545
0.1053
0.1
0.1053
0.1111
0.1
0.2
0.1
0.1
0.1818
0.1667
0.1
0.1
0.1296
0.1111
0.1538
0.1
0.1053
0.1053
0.1133
0.1143
0.1154
0.1
0.1
0.1
0.1069
0.4444
0.1538
0.1
0.1818
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1
0.1
0.1
0.1

0.1176
0.1
0.2
0.1538
0.12
0.16
0.1765
0.1
0.2
0.1818
0.1364
0.2
0.3333
0.1
0.1818
0.1765
0.186
0.2105
0.1
0.5161
0.1
0.1813
0.1385
0.2
0.1818
0.1429
0.1429
0.1
0.2
0.1
0.1
0.25
0.1429
0.1538
0.2
0.3017
0.1379
0.1875
0.1818
0.14
0.1667
0.25
0.1053
0.1509
0.1842
0.1538
0.3
0.1268
0.1333
0.1746
0.2
0.75
0.1538
0.1818
0.1333
0.1818
0.1
0.2
0.1
0.1333
0.25
0.2
0.1818
0.2
0.1905
0.2353
0.4167
0.4
0.1667
0.1711
0.1633
0.1297
0.1231
0.1
0.1026
0.1064
0.1111
0.8
0.2
0.1
0.2
0.2
0.1538
0.2
0.1429
0.1
0.1
0.1818
0.1111
0.1429
0.1
0.1429
0.1
0.1538
0.1
0.1

4
3
6
3
2
9
8
2
2
3
6
4
7
3
3
6
9
15
2
18
3
8
4
3
5
3
10
3
5
5
3
6
11
7
12
8
7
4
7
5
17
14
4
9
14
13
9
9
5
11
2
11
8
5
6
3
3
2
4
2
3
3
3
3
8
5
10
9
13
7
2
7
4
5
3
3
2
4
2
3
5
3
2
3
6
2
5
3
3
6
5
2
3
2
2
2

2
2
2
2
2
3
2
2
2
2
2
3
5
2
2
3
4
5
2
15
2
5
2
2
2
2
3
2
2
2
2
2
3
3
5
4
2
2
2
3
7
6
2
2
2
7
4
5
2
2
2
11
2
2
3
2
2
2
2
2
2
2
2
2
2
4
7
4
5
5
2
2
2
3
2
2
2
4
2
2
2
2
2
2
2
2
3
2
2
3
2
2
2
2
2
2

[17,20]
[10,10]
[11,18]
[13,29]
[25,30]
[25,51]
[17,47]
[10,10]
[10,10]
[11,14]
[18,22]
[10,18]
[11,26]
[10,20]
[33,59]
[17,38]
[15,149]
[20,73]
[10,10]
[31,201]
[10,10]
[158,257]
[50,65]
[10,10]
[11,18]
[14,23]
[25,110]
[10,10]
[10,20]
[10,10]
[10,10]
[20,20]
[21,46]
[13,36]
[11,21]
[93,144]
[29,29]
[10,16]
[10,12]
[39,50]
[40,104]
[31,55]
[19,20]
[41,58]
[39,59]
[21,57]
[10,20]
[57,143]
[15,61]
[124,126]
[10,10]
[11,35]
[13,19]
[11,11]
[15,28]
[10,12]
[10,11]
[10,10]
[10,10]
[10,15]
[11,12]
[10,12]
[10,11]
[10,10]
[54,70]
[18,35]
[10,17]
[10,23]
[16,58]
[16,84]
[346,459]
[191,459]
[26,65]
[10,10]
[10,39]
[30,48]
[108,132]
[10,27]
[10,13]
[10,10]
[10,11]
[10,10]
[10,13]
[10,10]
[10,15]
[10,10]
[10,10]
[10,11]
[10,18]
[14,17]
[10,20]
[10,14]
[10,10]
[10,13]
[10,10]
[10,10]

TableS10

chr10:103816292
chr11:63082528
chr16:82399159
chr22:27477229
chr19:54026737
chr19:16126299
chr14:101620494
chr14:101619971
chr14:101617879
chr14:101617878
chr14:101619969
chr14:101617892
chr14:101617910
chr14:101619955
chr14:101619970
chr14:101617135
chr14:101617137
chr14:101617153
chr14:101617521
chr14:101617527
chr6:44327809
chr6:44328822
chr6:44327731
chr6:44327783
chr6:44328823
chr6:44328874
chr6:44328871
chr6:44327720
chr6:44327730
chr6:44328869
chr6:44327737
chr6:44328998
chr6:44327939
chr6:44327960
chr6:44326909
chr6:44328865
chr6:44328971
chr6:44326906
chr6:44327736
chr6:44328978
chr6:44328990
chr6:44328999
chr6:44324385
chr6:44324386
chr6:44325092
chr6:44325093
chr6:44325098
chr6:44325107
chr6:44325129
chr6:44325149
chr6:44325155
chr6:44325203
chr6:44325205
chr6:44325209
chr6:44325215
chr6:44325248
chr6:44325250
chr6:44325508
chr6:44325751
chr6:44325769
chr6:44325772
chr6:44325812
chr6:44325813
chr6:44325816
chr6:44325841
chr6:44326193
chr6:44326204
chr6:44326816
chr6:44326822
chr6:44326846
chr6:44326854
chr6:44326875
chr6:44322829
chr12:102861718
chr12:102864581
chr12:102861093
chr12:102864599
chr12:102864586
chr12:102861072
chr12:102861745
chr12:102861101
chr12:102865720
chr10:14928847
chr5:132459768
chr4:128973785
chr9:127038352
chr9:127043423
chr5:137938981
chr2:198076081
chr2:198076074
chr2:198074130
chr2:198076072
chr2:198076091
chr2:198074144
chr2:198074189
chr2:198076079

HPS6
HRASLS2
HSBP1
HSCB
HSD17B14
HSH2D
HSP90AA2
HSP90AA2
HSP90AA2
HSP90AA2
HSP90AA2
HSP90AA2
HSP90AA2
HSP90AA2
HSP90AA2
HSP90AA2
HSP90AA2
HSP90AA2
HSP90AA2
HSP90AA2
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90AB1
HSP90B1
HSP90B1
HSP90B1
HSP90B1
HSP90B1
HSP90B1
HSP90B1
HSP90B1
HSP90B1
HSPA14
HSPA4
HSPA4L
HSPA5
HSPA5
HSPA9
HSPE1
HSPE1
HSPE1
HSPE1
HSPE1
HSPE1
HSPE1
HSPE1

coding_exon
coding_exon
UTR5
coding_exon
coding_exon
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR5
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon

ENST00000299238:EtoD;
ENST00000255695:VtoA;
ENST00000216027:AtoG;ENST00000398941:StoR;
ENST00000263278:KtoN;
ENST00000216281:YtoS;ENST00000334701:YtoS;
ENST00000216281:VtoA;ENST00000334701:VtoA;
ENST00000216281:TtoP;ENST00000334701:TtoP;ENST00000456274:TtoP;
ENST00000216281:TtoI;ENST00000334701:TtoI;ENST00000456274:TtoI;
ENST00000216281:KtoE;ENST00000334701:KtoE;

ENST00000353801:YtoN;ENST00000371554:YtoN;ENST00000371646:YtoN;
ENST00000353801:WtoC;ENST00000371554:WtoC;ENST00000371646:WtoC;
ENST00000353801:VtoL;ENST00000371554:VtoL;ENST00000371562:VtoL;ENST000
ENST00000353801:VtoA;ENST00000371554:VtoA;ENST00000371646:VtoA;
ENST00000353801:TtoP;ENST00000371554:TtoP;ENST00000371646:TtoP;
ENST00000353801:TtoA;ENST00000371554:TtoA;ENST00000371646:TtoA;
ENST00000353801:StoP;ENST00000371554:StoP;ENST00000371646:StoP;
ENST00000353801:StoI;ENST00000371554:StoI;ENST00000371556:StoI;ENST00000
ENST00000353801:QtoH;ENST00000371554:QtoH;ENST00000371556:QtoH;ENST0
ENST00000353801:NtoI;ENST00000371554:NtoI;ENST00000371646:NtoI;
ENST00000353801:NtoD;ENST00000371554:NtoD;ENST00000371562:NtoD;ENST00
ENST00000353801:LtoQ;ENST00000371554:LtoQ;ENST00000371646:LtoQ;
ENST00000353801:LtoP;ENST00000371554:LtoP;ENST00000371646:LtoP;
ENST00000353801:ItoN;ENST00000371554:ItoN;ENST00000371646:ItoN;
ENST00000353801:EtoD;ENST00000371554:EtoD;ENST00000371556:EtoD;ENST000
ENST00000353801:DtoN;ENST00000371554:DtoN;ENST00000371646:DtoN;
ENST00000353801:DtoG;ENST00000371554:DtoG;ENST00000371646:DtoG;
ENST00000353801:DtoE;ENST00000371554:DtoE;ENST00000371556:DtoE;ENST000

ENST00000299767:StoA;ENST00000421266:StoA;
ENST00000299767:RtoG;ENST00000421266:RtoG;
ENST00000299767:KtoE;ENST00000421266:KtoE;
ENST00000299767:ItoV;ENST00000421266:ItoV;
ENST00000299767:DtoE;ENST00000421266:DtoE;
ENST00000299767:AtoT;ENST00000421266:AtoT;
ENST00000299767:AtoS;ENST00000421266:AtoS;

ENST00000304858:VtoG;

ENST00000233893:VtoE;ENST00000409468:VtoE;ENST00000409729:VtoE;
ENST00000233893:TtoA;ENST00000409468:TtoA;ENST00000409729:TtoA;
ENST00000233893:ItoV;ENST00000409468:ItoV;
ENST00000233893:GtoD;ENST00000409468:GtoD;ENST00000409729:GtoD;
ENST00000233893:DtoE;ENST00000409468:DtoE;ENST00000409729:DtoE;

82

+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+

AtoC
TtoC
AtoC
CtoG
GtoC
GtoC
AtoC
TtoC
AtoC
CtoT
AtoG
TtoA
TtoG
AtoG
CtoT
TtoA
TtoA
CtoG
TtoG
TtoG
TtoA
GtoC
GtoC
TtoC
AtoC
AtoG
TtoC
GtoT
GtoT
AtoT
AtoG
TtoA
TtoC
TtoA
GtoC
GtoA
AtoG
TtoG
CtoA
AtoG
GtoT
GtoT
CtoG
TtoA
GtoC
CtoT
GtoC
CtoT
CtoT
AtoG
CtoT
GtoA
AtoG
AtoG
AtoG
TtoC
GtoT
AtoT
GtoA
TtoC
AtoG
GtoA
GtoA
AtoG
AtoT
AtoT
AtoC
TtoC
TtoG
GtoT
AtoT
TtoC
CtoT
TtoG
AtoG
AtoG
AtoG
CtoG
GtoA
GtoT
CtoT
TtoA
TtoC
TtoG
AtoG
TtoG
AtoT
TtoC
TtoA
AtoG
AtoG
GtoA
TtoA
AtoG
AtoT
AtoG

0.1429
0.1
0.1034
0.1
0.1667
0.1053
0.1
0.1
0.1053
0.1176
0.1333
0.1042
0.1143
0.1333
0.1538
0.1
0.1053
0.1077
0.1091
0.1023
0.1024
0.125
0.1017
0.1111
0.15
0.1
0.1538
0.1111
0.1043
0.15
0.1165
0.1538
0.1311
0.1
0.1304
0.129
0.1
0.1053
0.1038
0.5
0.1
0.1818
0.102
0.1111
0.12
0.1429
0.1
0.1
0.1111
0.129
0.15
0.1
0.1364
0.1
0.1
0.1429
0.125
0.16
0.1026
0.1071
0.122
0.1
0.1
0.1667
0.1
0.1
0.1111
0.1
0.1111
0.1
0.1429
0.1
0.1224
0.125
0.1
0.1765
0.1
0.1
0.1
0.1154
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1154
0.1
0.1
0.1
0.1081
0.1
0.1
0.1
0.1053

0.2
0.1
0.1134
0.1429
0.1739
0.2143
0.2
0.2143
0.1111
0.1818
0.25
0.1818
0.1379
0.1429
0.3333
0.3
0.3333
0.1111
0.3077
0.2093
0.2773
0.5294
0.1429
0.1781
0.7895
0.2222
0.3077
0.1194
0.1728
0.1724
0.1176
0.4286
0.1809
0.1429
0.2353
0.1538
0.1
0.1429
0.1044
0.7
0.1
0.5238
0.2
0.3462
0.2143
0.2
0.16
0.2
0.1212
0.2667
0.1579
0.3684
0.28
0.125
0.3125
0.2
0.1429
0.2
0.1111
0.2222
0.3333
0.125
0.1143
0.1818
0.1875
0.1667
0.1212
0.2371
0.3529
0.1111
0.2
0.1667
0.25
0.1333
0.1
0.2
0.1333
0.2
0.125
0.5
0.1818
0.1667
0.1333
0.1221
0.1
0.1
0.194
0.1667
0.1176
0.25
0.1471
0.2083
0.2
0.1
0.1667
0.1176

4
3
4
2
3
5
14
7
9
8
4
10
12
3
3
8
9
8
9
11
13
7
9
15
11
5
4
8
13
7
13
8
12
4
8
3
3
5
12
2
3
11
8
12
8
9
7
5
5
8
2
13
17
4
6
12
4
7
5
11
13
3
6
3
8
2
5
21
13
6
3
10
6
6
7
2
3
3
3
13
6
15
3
3
2
4
4
2
8
11
12
4
4
5
5
4

2
2
2
2
2
2
10
4
2
2
4
3
2
2
2
4
4
3
6
10
11
3
5
8
8
4
3
2
5
3
2
8
6
2
4
2
2
2
2
2
2
10
4
9
6
7
4
2
2
5
2
11
12
2
6
4
2
2
2
8
12
2
2
2
5
2
3
17
11
2
2
6
3
2
4
2
2
2
2
10
3
6
2
2
2
2
4
2
2
7
8
2
2
2
2
2

[10,14]
[10,30]
[29,98]
[10,14]
[12,23]
[14,57]
[10,42]
[14,25]
[27,38]
[11,51]
[10,15]
[24,48]
[29,35]
[14,16]
[10,14]
[10,17]
[12,26]
[36,65]
[25,78]
[18,155]
[33,184]
[17,24]
[83,178]
[28,205]
[12,34]
[10,16]
[13,14]
[18,68]
[81,176]
[18,29]
[102,104]
[10,22]
[26,101]
[14,21]
[16,28]
[13,34]
[10,20]
[14,19]
[106,251]
[11,17]
[10,10]
[10,25]
[10,64]
[19,72]
[14,27]
[12,22]
[19,32]
[10,10]
[33,36]
[10,31]
[21,40]
[13,44]
[11,39]
[10,24]
[10,16]
[10,24]
[16,21]
[10,25]
[39,46]
[22,50]
[14,45]
[16,20]
[20,38]
[12,13]
[10,16]
[10,13]
[10,34]
[26,180]
[18,94]
[10,18]
[10,21]
[15,30]
[20,49]
[15,40]
[10,10]
[10,18]
[10,15]
[10,11]
[10,16]
[10,49]
[11,20]
[31,131]
[10,15]
[54,131]
[10,10]
[10,20]
[15,68]
[12,26]
[11,17]
[13,33]
[23,47]
[24,37]
[10,10]
[10,10]
[12,30]
[17,19]

TableS10

chr13:30609486
chr13:30609487
chr13:30608808
chr11:20361810
chr4:3114304
chr4:3070892
chr4:3094415
chr4:3215368
chr12:109573422
chr3:50309843
chr11:125269085
chr11:118422340
chr11:118420299
chr11:118420967
chr15:41880103
chr15:41881326
chr2:9546585
chr9:94043005
chr9:94095576
chr19:10257447
chr17:59434871
chr19:10305699
chr1:6205174
chr1:6205700
chr21:44471760
chr21:44471761
chr10:94284490
chr10:94215450
chr10:94202042
chr15:76248632
chr20:2587057
chr6:30818958
chr6:30819436
chr6:30819455
chr12:6519126
chr17:38412334
chr1:78888796
chr1:27865167
chr1:27865412
chr2:162852969
chr10:91168375
chr10:91168107
chr10:91168089
chr11:305264
chr11:305266
chr11:305267
chr6:137560659
chr7:111902733
chr3:50300491
chr16:1579753
chr2:27526451
chr20:41704641
chr3:109365244
chr3:109421082
chr3:161619840
chr3:161629334
chr3:161629335
chr3:161632881
chr3:161636829
chr12:101320378
chr6:160446441
chr6:160446528
chr6:160446889
chr6:160447456
chr17:35866569
chr14:105796436
chr14:105401104
chr14:105796443
chr14:105389086
chr14:105901064
chr1:158331441
chr9:110681591
chr9:110698708
chr7:50439158
chr2:213573325
chr2:213575442
chr2:213577670
chr2:213578625
chr2:213579251
chr17:35169924
chr17:35171400
chr17:35173274
chr17:35175066
chr11:117375532
chr21:33574082
chr4:142859969
chr10:6034792
chr15:79379715
chr15:79392810
chr3:53874479
chr11:71391065
chr2:102372948
chr19:14018392
chr16:3055623
chr16:3055625
chr19:55084747

HSPH1
HSPH1
HSPH1
HTATIP2
HTT
HTT
HTT
HTT
HVCN1
HYAL3
HYLS1
HYOU1
HYOU1
HYOU1
HYPK
HYPK
IAH1
IARS
IARS
ICAM1
ICAM2
ICAM3
ICMT
ICMT
ICOSLG
ICOSLG
IDE
IDE
IDE
IDH3A
IDH3B
IER3
IER3
IER3
IFFO1
IFI35
IFI44
IFI6
IFI6
IFIH1
IFIT5
IFIT5
IFIT5
IFITM1
IFITM1
IFITM1
IFNGR1
IFRD1
IFRD2
IFT140
IFT172
IFT52
IFT57
IFT57
IFT80
IFT80
IFT80
IFT80
IFT80
IGF1
IGF2R
IGF2R
IGF2R
IGF2R
IGFBP4
IGHV36
IGHV36
IGHV36
IGHV36
IGHV36
IGSF8
IKBKAP
IKBKAP
IKZF1
IKZF2
IKZF2
IKZF2
IKZF2
IKZF2
IKZF3
IKZF3
IKZF3
IKZF3
IL10RA
IL10RB
IL15
IL15RA
IL16
IL16
IL17RB
IL18BP
IL18R1
IL27RA
IL32
IL32
IL4I1

coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
mixed
mixed
coding_exon
UTR3
UTR3
coding_exon
UTR3
mixed
coding_exon
UTR5
UTR3
coding_exon
coding_exon
UTR3
UTR3
mixed
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
mixed
coding_exon
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR5
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR5
UTR5
coding_exon

ENST00000320027:EtoV;ENST00000380405:EtoV;ENST00000380406:EtoV;ENST000
ENST00000320027:EtoQ;ENST00000380405:EtoQ;ENST00000380406:EtoQ;ENST00

ENST00000355072:YtoN;

ENST00000356742:VtoG;

ENST00000225760:TtoP;ENST00000412356:TtoP;ENST00000418105:TtoP;ENST000
ENST00000160262:VtoG;

ENST00000265986:LtoV;

ENST00000370747:StoP;

ENST00000371795:LtoH;ENST00000416601:LtoH;
ENST00000371795:KtoE;ENST00000416601:KtoE;
ENST00000371795:FtoV;ENST00000416601:FtoV;

ENST00000005558:StoP;ENST00000403825:StoP;

ENST00000260570:ItoN;ENST00000425023:ItoN;
ENST00000264538:VtoA;ENST00000457963:VtoA;

ENST00000422244:StoN;
ENST00000422244:PtoH;ENST00000426581:PtoH;
ENST00000422244:AtoT;

ENST00000314485:VtoE;ENST00000358475:VtoE;ENST00000368086:VtoE;
ENST00000374647:StoR;

ENST00000227752:LtoP;
ENST00000290200:TtoA;ENST00000433395:TtoA;

ENST00000302987:VtoG;ENST00000329842:VtoG;ENST00000355368:VtoG;ENST00

ENST00000233957:AtoE;ENST00000409599:AtoE;ENST00000410040:AtoE;
ENST00000263379:VtoA;

ENST00000319225:StoP;ENST00000341114:StoP;ENST00000391826:StoP;

83

+
+
+
+
+

+
+
+

+
+

+
+
+
+
+
+

+
+
+
+
+

+
+
+

+
+
+
+
+
+
+
+

AtoT
GtoC
TtoA
TtoA
TtoA
TtoG
TtoC
AtoG
TtoG
AtoG
AtoG
TtoA
CtoT
AtoT
TtoG
TtoA
GtoC
TtoA
CtoA
AtoG
AtoC
TtoG
AtoG
AtoG
CtoT
AtoC
TtoG
AtoG
AtoC
TtoC
TtoG
TtoA
TtoC
TtoA
TtoC
CtoT
TtoC
AtoG
CtoT
TtoG
TtoA
AtoG
TtoG
TtoC
CtoA
TtoG
AtoT
TtoC
TtoC
AtoG
TtoA
TtoC
TtoC
TtoC
TtoC
TtoC
TtoC
AtoT
TtoG
CtoT
TtoA
GtoA
TtoG
TtoA
TtoC
GtoA
CtoA
GtoA
TtoC
AtoG
TtoA
TtoG
AtoG
AtoG
GtoA
AtoG
GtoA
AtoG
TtoC
GtoA
TtoC
AtoT
AtoC
TtoC
AtoG
AtoT
AtoG
TtoG
AtoG
CtoA
AtoC
CtoA
TtoC
CtoG
GtoA
TtoC

0.1765
0.1538
0.1
0.1538
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1304
0.1667
0.125
0.1
0.1
0.1034
0.1
0.1034
0.1034
0.1121
0.1176
0.1
0.1
0.1111
0.1
0.1
0.1
0.1176
0.1
0.1667
0.1
0.1111
0.1176
0.125
0.1333
0.1296
0.1
0.1
0.1
0.1
0.1
0.1014
0.1
0.1
0.1875
0.1
0.1
0.1111
0.1
0.125
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1818
0.1
0.1
0.1053
0.1154
0.1
0.9091
0.9286
0.9891
0.1
0.3721
0.1
0.1
0.1
0.1818
0.1
0.1
0.1
0.1
0.125
0.1429
0.1364
0.1
0.1667
0.1
0.1
0.1
0.1
0.1013
0.1
0.1333
0.1
0.1
0.1
0.1333
0.1429
0.1

0.1818
0.2
0.1
0.1667
0.1429
0.1
0.1176
0.1
0.1585
0.1
0.1667
0.127
0.2143
0.4
0.1818
0.1429
0.1
0.119
0.1429
0.1053
0.1364
0.1446
0.3636
0.1111
0.1667
0.1429
0.1053
0.1
0.1667
0.2
0.1818
0.4
0.1538
0.1429
0.125
0.1818
0.1765
0.3091
0.1818
0.1111
0.1
0.2
0.1
0.15
0.1333
0.2308
0.2143
0.125
0.1
0.2
0.1429
0.2
0.1176
0.1111
0.1
0.2222
0.1429
0.1111
0.1
0.1818
0.1111
0.1333
0.1538
0.1429
0.1538
1
0.963
1
0.125
0.8667
0.1
0.125
0.1
0.1818
0.1053
0.129
0.1333
0.1111
0.1304
0.2727
0.1818
0.1
0.3333
0.1667
0.1
0.1818
0.1
0.1389
0.1
0.1429
0.1111
0.12
0.1818
0.1667
0.1538
0.16

2
2
4
5
5
2
2
2
6
2
3
9
7
2
6
10
2
9
2
4
7
5
6
3
5
10
2
2
2
3
2
2
3
3
3
2
4
12
7
4
2
2
4
12
7
3
3
3
3
2
2
6
3
3
3
4
2
2
4
3
7
4
4
6
4
3
2
2
2
2
2
5
2
6
2
4
2
4
4
9
6
4
11
3
3
6
2
9
2
2
4
2
3
2
2
12

2
2
2
2
2
2
2
2
2
2
2
3
4
2
2
6
2
3
2
2
2
3
4
2
2
3
2
2
2
3
2
2
3
2
2
2
2
12
5
2
2
2
3
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
5
3
2
4
2
2
4
2
3
2
2
2
2
2
2
2
5

[11,17]
[10,13]
[10,20]
[12,13]
[10,14]
[10,10]
[10,17]
[10,10]
[59,83]
[10,10]
[10,12]
[10,127]
[14,26]
[12,15]
[11,24]
[10,32]
[10,10]
[18,42]
[10,14]
[19,29]
[22,29]
[79,166]
[10,17]
[10,10]
[18,40]
[14,36]
[11,19]
[10,10]
[12,20]
[10,17]
[11,12]
[11,13]
[10,36]
[18,21]
[16,17]
[11,16]
[15,17]
[13,58]
[11,33]
[10,38]
[10,10]
[10,10]
[10,10]
[16,70]
[10,46]
[13,32]
[14,16]
[10,16]
[10,10]
[10,10]
[10,14]
[10,16]
[10,17]
[10,18]
[10,30]
[19,30]
[10,14]
[10,20]
[10,22]
[11,11]
[11,19]
[10,15]
[13,19]
[21,27]
[10,17]
[59,95]
[14,27]
[17,185]
[10,17]
[30,44]
[10,10]
[16,21]
[10,10]
[11,12]
[10,19]
[10,31]
[10,15]
[10,27]
[16,23]
[11,19]
[11,22]
[10,10]
[10,13]
[10,12]
[10,20]
[10,14]
[10,10]
[37,79]
[10,10]
[14,16]
[10,10]
[10,25]
[10,11]
[12,15]
[13,14]
[25,130]

TableS10

chr16:27282602
chr16:27283351
chr1:152706084
chr5:55276217
chr5:55276235
chr5:55276273
chr19:10656777
chr19:10661525
chr11:6588660
chr2:86239293
chr15:73718490
chr15:73718493
chr15:73718507
chr2:130820655
chr3:49036798
chr14:104252110
chr2:190944079
chr2:190944393
chr2:98537341
chr2:98526880
chr1:38111237
chr1:38099404
chr17:1345698
chr11:71627765
chr2:118583530
chr19:7117337
chr19:7063717
chr19:7066491
chr19:7067317
chr7:1506135
chr4:106836217
chr4:106836245
chr4:106823331
chr1:152013072
chr1:210247292
chr1:210181794
chr8:28760234
chr8:28691324
chr3:49736992
chr3:49739476
chr3:48703890
chr5:61960101
chr1:44205953
chr1:44206003
chr11:9411918
chr11:9420282
chr1:200106918
chr3:199161471
chr3:199161472
chr3:199167115
chr15:88839018
chr15:88845255
chr15:88845392
chr5:75984371
chr5:76005533
chr3:12917140
chr3:12913744
chr3:12915364
chr12:64928237
chr12:42466627
chr12:42463779
chr15:76551319
chr15:76573375
chr15:76577669
chr1:232807016
chr1:232807766
chr1:232808840
chr1:232808841
chr19:54860701
chr7:128376626
chr11:602563
chr16:84513117
chr19:48785220
chr14:74031709
chr14:74031712
chr12:107482056
chr12:107482058
chr1:154963323
chr1:154958985
chr5:128470628
chr5:128477140
chr20:32560731
chr20:32560874
chr16:250154
chr2:182104651
chr17:3576065
chr10:33252584
chr21:45130366
chr13:47733318
chr14:92475959
chr14:92475960
chr1:224991037
chr1:224886156
chr3:4804754
chr12:26538403
chr12:26666602

IL4R
IL4R
IL6R
IL6ST
IL6ST
IL6ST
ILF3
ILF3
ILK
IMMT
IMP3
IMP3
IMP3
IMP4
IMPDH2
INF2
INPP1
INPP1
INPP4A
INPP4A
INPP5B
INPP5B
INPP5K
INPPL1
INSIG2
INSR
INSR
INSR
INSR
INTS1
INTS12
INTS12
INTS12
INTS3
INTS7
INTS7
INTS9
INTS9
IP6K1
IP6K1
IP6K2
IPO11
IPO13
IPO13
IPO7
IPO7
IPO9
IQCG
IQCG
IQCG
IQGAP1
IQGAP1
IQGAP1
IQGAP2
IQGAP2
IQSEC1
IQSEC1
IQSEC1
IRAK3
IRAK4
IRAK4
IREB2
IREB2
IREB2
IRF2BP2
IRF2BP2
IRF2BP2
IRF2BP2
IRF3
IRF5
IRF7
IRF8
IRGQ
ISCA2
ISCA2
ISCU
ISCU
ISG20L2
ISG20L2
ISOC1
ISOC1
ITCH
ITCH
ITFG3
ITGA4
ITGAE
ITGB1
ITGB2
ITM2B
ITPK1
ITPK1
ITPKB
ITPKB
ITPR1
ITPR2
ITPR2

coding_exon
UTR3
UTR3
mixed
mixed
mixed
mixed
UTR3
UTR3
coding_exon
mixed
mixed
mixed
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
mixed
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR5
UTR5
UTR5
coding_exon
UTR3
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
mixed
mixed
coding_exon
UTR3
coding_exon
coding_exon
coding_exon

ENST00000170630:KtoE;ENST00000395762:KtoE;

ENST00000252520:LtoP;ENST00000330634:LtoP;ENST00000339008:LtoP;ENST0000

ENST00000074304:NtoT;ENST00000409016:NtoT;ENST00000409540:NtoT;ENST00

ENST00000265150:KtoE;ENST00000340139:KtoE;ENST00000394735:KtoE;ENST000

ENST00000366992:StoP;ENST00000366993:StoP;ENST00000366994:StoP;ENST000
ENST00000366992:FtoL;ENST00000366993:FtoL;ENST00000366994:FtoL;ENST0000
ENST00000416984:EtoD;
ENST00000416984:CtoR;

ENST00000328631:LtoQ;ENST00000395507:LtoQ;ENST00000395509:LtoQ;

ENST00000379719:LtoI;
ENST00000379719:DtoG;
ENST00000361565:ItoL;

ENST00000274364:HtoR;ENST00000396234:HtoR;

ENST00000356669:KtoN;ENST00000431837:KtoN;ENST00000440781:KtoN;ENST00
ENST00000258886:Wto*;

ENST00000338291:TtoI;ENST00000392807:TtoI;
ENST00000338291:Qto*;ENST00000392807:Qto*;
ENST00000313146:QtoR;ENST00000368219:QtoR;
ENST00000173527:MtoV;

ENST00000301678:FtoL;ENST00000301679:FtoL;ENST00000399932:FtoL;ENST0000
ENST00000397033:HtoR;
ENST00000302252:ItoV;ENST00000302278:ItoV;ENST00000359614:ItoV;ENST0000
ENST00000378549:HtoR;ENST00000378565:HtoR;

ENST00000272117:QtoR;ENST00000429204:QtoR;
ENST00000302640:KtoE;ENST00000354582:KtoE;ENST00000356617:KtoE;ENST000
ENST00000381340:GtoS;ENST00000451599:GtoS;

84

+
+
+

+
+
+

+
+
+
+
+

+
+

+
+
+
+
+
+

+
+
+
+
+

+
+
+
+
+
+

+
+
+
+

+
+
+
+
+
+

AtoG
TtoC
GtoT
GtoA
CtoA
GtoT
AtoT
GtoA
TtoA
TtoC
AtoG
TtoC
AtoG
TtoC
TtoC
TtoC
TtoG
TtoG
AtoC
GtoC
CtoA
AtoG
TtoA
GtoA
AtoG
AtoG
CtoA
AtoG
TtoG
AtoG
AtoG
AtoG
AtoG
AtoG
TtoC
TtoC
GtoC
TtoC
AtoC
AtoG
TtoA
AtoC
AtoG
TtoC
CtoA
AtoG
AtoC
GtoA
TtoG
AtoT
AtoG
TtoC
CtoG
AtoG
TtoA
AtoG
AtoG
CtoG
GtoA
GtoT
TtoC
GtoA
TtoA
GtoT
TtoG
AtoG
TtoG
GtoT
AtoC
TtoC
TtoC
TtoA
GtoA
TtoC
GtoA
CtoT
CtoT
AtoG
TtoC
AtoG
AtoG
TtoG
TtoC
TtoC
AtoG
TtoC
AtoG
AtoG
AtoG
TtoA
AtoG
AtoG
AtoG
AtoG
GtoA
AtoG

0.1
0.1
0.1
0.16
0.996
0.15
0.125
0.1304
0.1
0.102
0.2
0.1538
0.1176
0.1
0.1
0.1364
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1875
0.1304
0.125
0.1
0.1111
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1364
0.1034
0.4211
0.1
0.1
0.3333
0.1
0.1
0.1
0.1538
0.2
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1034
0.1875
0.1333
0.1333
0.1111
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1053
0.1
0.1
0.125
0.1
0.1
0.1

0.1
0.1333
0.1
0.1875
1
0.2273
0.1364
0.2
0.1923
0.1176
0.2308
0.1538
0.1333
0.2083
0.2692
0.1538
0.1
0.1667
0.125
0.1
0.1
0.1304
0.1
0.2857
0.1
0.1
0.1
0.1053
0.2222
0.1538
0.2
0.1667
0.3
0.2727
0.1429
0.1818
0.1
0.1
0.1667
0.1
0.1875
0.1
0.1429
0.1429
0.1333
0.2222
0.125
0.2105
0.2353
0.7222
0.1538
0.1667
0.5455
0.1429
0.1
0.1111
0.1818
0.25
0.1
0.1
0.1
0.1
0.1818
0.1
0.1
0.1538
0.1071
0.2727
0.3
0.2143
0.1875
0.1905
0.1818
0.1176
0.1053
0.1333
0.1
0.1
0.1
0.2
0.1667
0.1429
0.1
0.1818
0.1667
0.1
0.1
0.1154
0.1176
0.2
0.2222
0.1538
0.1667
0.125
0.1
0.2

3
2
2
7
12
6
2
6
3
5
2
4
7
4
15
2
3
2
3
2
2
3
2
6
2
3
2
2
5
3
3
2
4
5
5
4
2
3
2
2
9
3
3
5
2
2
2
5
6
4
6
5
3
2
2
5
2
2
2
3
5
2
3
2
4
2
5
5
4
10
5
6
3
6
3
3
4
2
2
3
2
2
2
3
8
2
6
8
3
8
6
3
3
2
2
2

2
2
2
3
12
4
2
3
2
2
2
2
3
2
9
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
3
2
2
2
2
2
2
3
4
4
2
2
3
2
2
2
2
2
2
2
3
2
2
2
2
2
3
5
2
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
4
5
2
2
2
2
2

[10,10]
[10,15]
[10,10]
[16,30]
[320,1635]
[10,42]
[16,22]
[10,27]
[20,26]
[17,49]
[10,13]
[13,13]
[16,23]
[20,25]
[15,57]
[13,23]
[10,10]
[10,12]
[16,20]
[10,10]
[10,10]
[23,38]
[10,10]
[10,14]
[10,10]
[10,10]
[10,10]
[19,20]
[16,18]
[13,23]
[10,16]
[10,12]
[10,18]
[10,11]
[10,14]
[10,11]
[10,10]
[10,10]
[10,12]
[10,10]
[17,40]
[10,10]
[10,14]
[10,14]
[10,15]
[10,10]
[10,16]
[19,30]
[17,30]
[13,23]
[10,13]
[18,20]
[11,14]
[10,14]
[10,10]
[10,18]
[12,13]
[10,12]
[10,10]
[10,10]
[10,10]
[10,10]
[10,11]
[10,10]
[10,10]
[10,13]
[10,28]
[11,29]
[10,16]
[14,37]
[16,45]
[22,36]
[10,11]
[17,18]
[19,20]
[10,15]
[10,10]
[10,10]
[10,10]
[10,10]
[10,12]
[10,14]
[10,10]
[10,11]
[10,12]
[10,10]
[10,20]
[19,26]
[10,17]
[15,25]
[10,22]
[10,13]
[12,17]
[10,16]
[10,10]
[10,10]

TableS10

chr12:26726148
chr12:26380105
chr12:26381097
chr12:26381107
chr12:26381108
chr12:26381369
chr12:26383149
chr6:33731553
chr6:33760155
chr6:33755773
chr10:106062970
chr2:24334466
chr2:24325232
chr2:24388712
chr15:38497848
chr15:38498319
chr15:38500366
chr1:183533525
chr1:183533595
chr1:183533728
chr2:127955046
chr2:127955047
chr3:9910528
chr1:65098412
chr21:25996414
chr6:15621214
chr14:75006550
chr17:72226173
chr16:673532
chr16:671680
chr16:672748
chr22:37411681
chr22:37412780
chr14:23108229
chr19:12765027
chr16:74233110
chr16:74219162
chr17:37524728
chr6:150001321
chr11:47550697
chr2:85108563
chr1:6083285
chr1:6083286
chr1:6083669
chr1:6083821
chr17:59020652
chr17:59022438
chr17:59116671
chr17:59116672
chr12:108382824
chr12:108371300
chr12:108371343
chr17:70572323
chr6:36565445
chr11:107849343
chr19:53584669
chr7:6469045
chr1:23281443
chr11:66739928
chr11:66780005
chr11:66780378
chr11:66780411
chr12:120471165
chr12:120351711
chr5:137755483
chr5:137799418
chr5:137800310
chr5:137800469
chr19:5061795
chr19:5082097
chr19:5103120
chr19:5103126
chr19:5104603
chr12:292607
chr12:312997
chr12:275043
chr12:265030
chr12:264669
chr17:7690999
chr17:7697093
chr17:7690265
chr17:7698028
chr17:7698171
chr18:59153497
chr19:6366156
chr19:6364536
chr19:6364740
chr1:173393706
chr1:173394013
chr1:19418760
chr1:19432111
chr1:19432207
chr15:62445235
chr15:62445239
chr5:141298499
chr16:70514018

ITPR2
ITPR2
ITPR2
ITPR2
ITPR2
ITPR2
ITPR2
ITPR3
ITPR3
ITPR3
ITPRIP
ITSN2
ITSN2
ITSN2
IVD
IVD
IVD
IVNS1ABP
IVNS1ABP
IVNS1ABP
IWS1
IWS1
JAGN1
JAK1
JAM2
JARID2
JDP2
JMJD6
JMJD8
JMJD8
JMJD8
JOSD1
JOSD1
JPH4
JUNB
KARS
KARS
KAT2A
KATNA1
KBTBD4
KCMF1
KCNAB2
KCNAB2
KCNAB2
KCNAB2
KCNH6
KCNH6
KCNH6
KCNH6
KCTD10
KCTD10
KCTD10
KCTD2
KCTD20
KDELC2
KDELR1
KDELR2
KDM1
KDM2A
KDM2A
KDM2A
KDM2A
KDM2B
KDM2B
KDM3B
KDM3B
KDM3B
KDM3B
KDM4B
KDM4B
KDM4B
KDM4B
KDM4B
KDM5A
KDM5A
KDM5A
KDM5A
KDM5A
KDM6B
KDM6B
KDM6B
KDM6B
KDM6B
KDSR
KHSRP
KHSRP
KHSRP
KIAA0040
KIAA0040
KIAA0090
KIAA0090
KIAA0090
KIAA0101
KIAA0101
KIAA0141
KIAA0174

coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
mixed
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon

ENST00000374316:YtoN;
ENST00000374316:LtoM;
ENST00000374316:DtoA;
ENST00000355123:GtoR;ENST00000361999:GtoR;ENST00000380868:GtoR;ENST00

ENST00000342505:VtoA;
ENST00000312957:VtoA;ENST00000400532:VtoA;ENST00000400533:VtoA;ENST00

ENST00000293882:NtoK;ENST00000412368:NtoK;ENST00000454700:NtoK;

ENST00000302754:HtoR;

ENST00000335643:LtoP;ENST00000335647:LtoP;ENST00000367411:LtoP;

ENST00000330720:TtoP;

ENST00000401583:CtoG;

ENST00000261824:KtoR;ENST00000377069:KtoR;ENST00000377071:KtoR;ENST000
ENST00000314358:GtoR;ENST00000394866:GtoR;

ENST00000159111:StoP;ENST00000381759:StoP;
ENST00000159111:RtoS;

ENST00000382815:VtoA;ENST00000399787:VtoA;ENST00000399788:VtoA;
ENST00000382815:EtoK;ENST00000399787:EtoK;ENST00000399788:EtoK;
ENST00000382815:AtoV;ENST00000399787:AtoV;ENST00000399788:AtoV;

ENST00000254846:StoR;ENST00000448097:StoR;
ENST00000254846:LtoR;ENST00000448097:LtoR;

ENST00000398148:QtoP;

ENST00000375199:YtoH;ENST00000375208:YtoH;ENST00000477853:YtoH;
ENST00000375184:RtoQ;ENST00000375199:RtoQ;ENST00000375208:RtoQ;ENST00
ENST00000375184:LtoP;ENST00000375199:LtoP;ENST00000375208:LtoP;ENST0000

85

+
+
+

+
+
+

+
+
+

+
+
+
+
+
+
+
+
+

+
+

+
+
+
+
+

+
+
+
+
+
+
+
+
+

+
+
+
+
+

+
+

CtoA
AtoG
AtoC
GtoA
AtoG
TtoC
TtoA
TtoA
CtoA
AtoC
AtoG
GtoA
TtoC
TtoC
TtoG
GtoA
TtoA
AtoG
TtoG
AtoG
AtoG
CtoA
TtoC
TtoC
TtoC
TtoC
CtoA
AtoG
TtoA
TtoA
CtoT
TtoC
AtoG
TtoC
AtoG
AtoG
AtoG
CtoT
TtoC
AtoG
TtoC
GtoC
AtoG
TtoC
AtoG
TtoC
AtoG
GtoC
TtoC
AtoG
TtoC
AtoG
TtoC
AtoG
TtoC
AtoC
AtoT
AtoC
TtoG
TtoC
GtoA
AtoG
AtoG
AtoG
GtoA
TtoC
CtoG
TtoG
TtoC
GtoC
CtoG
GtoA
TtoC
TtoC
GtoA
CtoT
TtoA
AtoC
TtoG
TtoG
AtoG
AtoC
AtoC
AtoG
AtoC
TtoC
AtoC
TtoC
AtoC
TtoC
GtoA
TtoC
AtoG
TtoC
TtoG
CtoA

0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1154
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1176
0.1
0.1026
0.1176
0.1111
0.1364
0.1
0.2373
0.1042
0.1
0.1
0.1176
0.1071
0.24
0.2353
0.1
0.125
0.122
0.1
0.1667
0.1
0.1
0.1
0.125
0.1
0.1
0.1
0.1148
0.1
0.1111
0.1
0.1
0.1
0.1
0.1667
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1429
0.1071
0.1333
0.1
0.1
0.1
0.125
0.1667
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1071
0.1042
0.1
0.1
0.1154
0.1
0.1
0.1053
0.1
0.1
0.1351

0.1333
0.2308
0.1176
0.2
0.1667
0.125
0.1818
0.1
0.1429
0.1
0.1
0.1304
0.1818
0.1
0.1
0.1818
0.1
0.1176
0.1
0.1053
0.1176
0.1111
0.1
0.125
0.1
0.2
0.1
0.2941
0.1765
0.1818
0.1111
0.2
0.1111
0.1579
0.1538
0.4015
0.1379
0.1
0.1
0.2
0.1429
0.4884
0.3333
0.2
0.1667
0.1304
0.1818
0.2
0.1875
0.1
0.1
0.1667
0.1
0.3333
0.1
0.2353
0.1081
0.1667
0.2
0.1176
0.1538
0.125
0.6
0.1765
0.1
0.1176
0.1667
0.2
0.1
0.125
0.1538
0.1538
0.2
0.1429
0.2
0.125
0.1429
0.2632
0.1
0.1
0.1
0.1111
0.125
0.1818
0.2083
0.1235
0.1471
0.1
0.25
0.2
0.125
0.1111
0.1176
0.1176
0.1
0.2115

3
3
2
3
3
3
4
3
2
2
2
2
4
5
2
5
4
5
7
2
10
4
5
4
2
4
2
6
5
2
5
6
5
7
10
2
12
6
3
8
7
4
4
4
7
2
8
5
4
3
2
4
3
9
2
4
4
13
2
2
2
2
6
7
3
5
4
2
2
3
4
2
5
4
3
2
7
6
2
2
2
2
3
2
5
4
4
3
5
5
2
5
3
7
4
4

2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
4
2
3
4
2
4
2
2
3
3
4
4
2
2
2
3
3
2
2
2
2
2
6
2
2
2
5
2
2
2
2
6
2
2
2
2
2
2
2
2
2
3
2
3
2
2
4
2
2
2
2
3
2
4
3
4
2
4
2
2
2
2
3
2
2

[10,15]
[10,13]
[10,17]
[10,10]
[10,12]
[10,16]
[11,16]
[10,10]
[10,14]
[10,10]
[10,10]
[10,23]
[10,11]
[10,30]
[10,10]
[11,18]
[10,10]
[17,20]
[10,11]
[10,19]
[17,26]
[10,18]
[10,10]
[10,16]
[10,10]
[10,16]
[10,10]
[17,20]
[17,17]
[10,11]
[27,39]
[10,17]
[18,18]
[19,36]
[13,44]
[59,137]
[19,49]
[10,10]
[10,10]
[10,17]
[21,30]
[24,43]
[17,34]
[15,20]
[16,42]
[23,42]
[10,16]
[10,18]
[10,17]
[10,20]
[10,10]
[12,16]
[10,10]
[10,20]
[10,10]
[17,61]
[20,37]
[19,36]
[10,10]
[10,17]
[10,13]
[10,16]
[10,14]
[10,17]
[10,10]
[10,17]
[12,20]
[10,10]
[10,20]
[10,17]
[21,26]
[13,28]
[10,15]
[14,20]
[10,10]
[10,16]
[17,21]
[13,19]
[10,10]
[10,10]
[10,10]
[10,10]
[10,16]
[10,11]
[25,41]
[28,81]
[29,96]
[10,10]
[10,15]
[10,26]
[10,16]
[10,18]
[17,19]
[11,27]
[10,20]
[37,52]

TableS10

chr16:70514772
chr16:84245995
chr16:84266124
chr16:84266408
chr16:84266986
chr16:84267149
chr17:70999575
chr17:70999576
chr17:71001451
chr17:71007022
chr8:126154622
chr3:198905643
chr3:198893832
chr3:198912326
chr3:198884763
chr3:198886234
chr6:42943706
chr14:69247629
chr1:35691753
chr9:113176115
chr9:113188552
chr9:113214220
chr9:113214221
chr9:113164016
chr14:34662493
chr20:36074379
chr20:36044891
chr7:4796083
chr7:4796082
chr7:4773595
chr7:4777352
chr16:15598187
chr16:15595753
chr16:15596013
chr1:46954664
chr1:46927849
chr12:22493082
chr13:41077329
chr13:41062797
chr13:41087197
chr14:58035355
chr11:46652258
chr11:46652553
chr11:46596007
chr17:2546766
chr17:2546579
chr17:2539435
chr12:53646183
chr12:53647245
chr12:53654657
chr17:6440223
chr19:19307995
chr19:19329260
chr19:19329283
chr1:154162102
chr1:154149729
chr1:154149733
chr1:154150201
chr10:75227206
chr10:75218480
chr4:154744729
chr5:5517758
chr18:27673321
chr12:104085433
chr7:141032853
chr7:141003744
chr7:141004275
chr7:141005075
chr7:141005208
chr5:175719173
chr5:175719444
chr5:175721296
chr20:36594859
chr20:36636966
chr10:70445416
chr2:96634297
chr2:96633816
chr8:95612422
chr8:95571473
chr8:95576267
chr8:95577771
chr4:186348889
chr4:186318571
chr4:186320622
chr9:5736004
chr9:5764613
chr9:5764741
chr11:93103115
chr11:93103163
chr11:93103168
chr14:76650885
chr9:20913760
chr11:105385761
chr2:61224503
chr8:22520142
chr1:11902346

KIAA0174
KIAA0182
KIAA0182
KIAA0182
KIAA0182
KIAA0182
KIAA0195
KIAA0195
KIAA0195
KIAA0195
KIAA0196
KIAA0226
KIAA0226
KIAA0226
KIAA0226
KIAA0226
KIAA0240
KIAA0247
KIAA0319L
KIAA0368
KIAA0368
KIAA0368
KIAA0368
KIAA0368
KIAA0391
KIAA0406
KIAA0406
KIAA0415
KIAA0415
KIAA0415
KIAA0415
KIAA0430
KIAA0430
KIAA0430
KIAA0494
KIAA0494
KIAA0528
KIAA0564
KIAA0564
KIAA0564
KIAA0586
KIAA0652
KIAA0652
KIAA0652
KIAA0664
KIAA0664
KIAA0664
KIAA0748
KIAA0748
KIAA0748
KIAA0753
KIAA0892
KIAA0892
KIAA0892
KIAA0907
KIAA0907
KIAA0907
KIAA0907
KIAA0913
KIAA0913
KIAA0922
KIAA0947
KIAA1012
KIAA1033
KIAA1147
KIAA1147
KIAA1147
KIAA1147
KIAA1147
KIAA1191
KIAA1191
KIAA1191
KIAA1219
KIAA1219
KIAA1279
KIAA1310
KIAA1310
KIAA1429
KIAA1429
KIAA1429
KIAA1429
KIAA1430
KIAA1430
KIAA1430
KIAA1432
KIAA1432
KIAA1432
KIAA1731
KIAA1731
KIAA1731
KIAA1737
KIAA1797
KIAA1826
KIAA1841
KIAA1967
KIAA2013

coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
mixed
mixed
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR5
coding_exon
coding_exon
UTR3
mixed
mixed
UTR5
coding_exon
mixed
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR5
UTR5
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
mixed
coding_exon
UTR3

ENST00000314256:KtoR;ENST00000375248:KtoR;
ENST00000314256:KtoN;ENST00000375248:KtoN;
ENST00000314256:CtoR;ENST00000375248:CtoR;
ENST00000318410:CtoR;
ENST00000273582:StoG;ENST00000296343:StoG;ENST00000389665:StoG;ENST000
ENST00000273582:AtoS;ENST00000296343:AtoS;ENST00000389665:AtoS;ENST000

ENST00000348624:HtoR;ENST00000401897:HtoR;ENST00000450194:HtoR;
ENST00000348624:HtoD;ENST00000401897:HtoD;ENST00000450194:HtoD;

ENST00000321370:VtoE;ENST00000344181:VtoE;ENST00000396368:VtoE;

ENST00000371933:LtoH;
ENST00000371933:KtoN;
ENST00000251030:LtoP;ENST00000379310:LtoP;

ENST00000322335:TtoA;ENST00000435359:TtoA;
ENST00000322335:DtoA;ENST00000435359:DtoA;

ENST00000361413:MtoI;

ENST00000368319:CtoG;ENST00000368320:CtoG;ENST00000368321:CtoG;

ENST00000398706:RtoG;ENST00000412131:RtoG;ENST00000414462:RtoG;ENST00
ENST00000361316:ItoV;ENST00000409663:ItoV;ENST00000409959:ItoV;ENST0000
ENST00000296564:GtoW;
ENST00000283351:TtoK;ENST00000451747:TtoK;
ENST00000297761:StoP;ENST00000482493:StoP;

ENST00000262879:TtoA;ENST00000304939:TtoA;ENST00000397038:TtoA;ENST000
ENST00000262879:EtoA;ENST00000304939:EtoA;ENST00000397038:EtoA;ENST000
ENST00000354204:LtoP;ENST00000421845:LtoP;ENST00000431828:LtoP;ENST0000
ENST00000354204:AtoT;ENST00000421845:AtoT;ENST00000431828:AtoT;ENST000

ENST00000251879:DtoA;ENST00000381532:DtoA;ENST00000414202:DtoA;ENST00

ENST00000338382:LtoR;ENST00000380249:LtoR;
ENST00000301919:LtoR;

86

+
+
+
+
+
+
+
+
+
+

+
+

+
+
+
+

+
+
+
+

+
+
+

+
+
+
+

+
+
+

+
+
+
+
+
+
+
+

+
+

AtoG
CtoA
AtoG
TtoG
AtoG
TtoC
AtoG
GtoC
TtoC
TtoG
TtoC
AtoG
GtoT
CtoA
AtoC
TtoC
TtoG
TtoC
AtoG
TtoC
TtoA
GtoT
TtoC
TtoC
TtoC
CtoA
TtoA
AtoG
CtoG
AtoC
AtoG
TtoA
GtoA
TtoC
TtoA
AtoC
TtoG
TtoC
TtoC
TtoC
AtoG
AtoG
TtoC
AtoG
AtoG
AtoC
TtoC
AtoG
TtoC
AtoC
GtoA
AtoC
CtoT
AtoT
TtoG
TtoA
TtoC
CtoA
AtoG
AtoG
AtoG
GtoT
CtoA
TtoA
TtoC
TtoC
AtoG
GtoA
TtoG
GtoT
TtoG
AtoC
AtoG
AtoC
TtoC
TtoC
GtoA
TtoC
TtoC
TtoA
TtoC
TtoA
AtoC
TtoC
AtoC
TtoC
TtoC
TtoC
AtoT
AtoG
GtoT
TtoG
TtoG
AtoT
CtoT
AtoG

0.1176
0.1
0.1
0.1429
0.1
0.1
0.1
0.1364
0.1053
0.1333
0.1
0.1
0.1667
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1333
0.1429
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1379
0.1
0.1
0.1
0.1
0.1667
0.1
0.1
0.1
0.1
0.1379
0.1
0.1053
0.1
0.125
0.1
0.1
0.1333
0.1
0.1
0.3214
0.1111
0.1
0.1081
0.1
0.1429
0.1
0.1
0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.3939
0.1
0.1
0.1
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.125
0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1

0.125
0.1
0.1
0.1429
0.1
0.1
0.2143
0.2353
0.1053
0.1818
0.1111
0.1429
0.2143
0.2105
0.1818
0.1111
0.1
0.1053
0.1
0.1111
0.2
0.1429
0.1429
0.1818
0.1
0.1
0.1
0.2727
0.1667
0.1053
0.1667
0.1
0.1818
0.1176
0.1333
0.1333
0.1
0.1818
0.1538
0.1
0.1818
0.1111
0.2
0.1
0.2667
0.1818
0.1818
0.1333
0.12
0.25
0.1
0.1667
0.381
0.125
0.1
0.125
0.1667
0.1818
0.1
0.2727
0.1429
0.1
0.1
0.1818
0.125
0.1667
0.1111
0.5789
0.1818
0.1176
0.2
0.1333
0.1
0.1
0.1333
0.1
0.1538
0.1
0.1429
0.1667
0.1364
0.1176
0.1579
0.2727
0.1
0.1
0.125
0.2
0.125
0.1176
0.2
0.1667
0.1333
0.1538
0.1379
0.1053

4
2
2
2
2
4
3
4
4
2
3
5
2
3
2
4
5
4
2
2
4
4
5
3
3
4
3
5
5
2
4
2
2
2
5
2
2
3
3
3
2
3
2
2
5
4
7
3
4
6
2
4
2
2
2
4
5
5
4
5
2
2
2
3
3
5
2
2
5
5
3
2
2
2
3
2
5
2
4
5
2
4
2
3
2
6
5
2
2
6
3
5
6
2
4
3

2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
3
2
2
2
2
3
2
2
2
2
2
2
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
5
3
2
2
2
2
2
2
2
2
2
2
3
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
3
3
2
2
2

[16,17]
[10,10]
[10,10]
[14,14]
[10,10]
[10,10]
[10,14]
[17,22]
[19,19]
[11,15]
[10,18]
[14,20]
[14,18]
[18,19]
[10,11]
[10,18]
[10,10]
[10,19]
[10,10]
[10,18]
[10,17]
[14,17]
[14,15]
[11,14]
[10,10]
[10,10]
[10,10]
[10,18]
[10,20]
[10,19]
[10,12]
[10,10]
[11,29]
[10,18]
[10,15]
[10,15]
[10,10]
[12,22]
[10,13]
[10,10]
[10,11]
[10,18]
[10,29]
[10,10]
[15,37]
[10,25]
[11,16]
[10,15]
[10,25]
[15,16]
[10,10]
[10,12]
[21,28]
[16,27]
[10,10]
[16,41]
[10,19]
[11,21]
[10,10]
[10,15]
[14,34]
[10,10]
[10,10]
[10,11]
[10,16]
[12,20]
[18,30]
[19,33]
[11,11]
[17,20]
[10,10]
[15,16]
[10,10]
[10,10]
[10,15]
[10,10]
[10,13]
[10,10]
[20,21]
[10,12]
[10,22]
[10,35]
[16,19]
[11,15]
[10,10]
[10,10]
[11,16]
[10,10]
[10,16]
[11,18]
[10,10]
[10,20]
[11,20]
[10,13]
[10,29]
[10,19]

TableS10

chr9:5958025
chr2:8788824
chr2:8794529
chr10:94403522
chr10:94362855
chr3:44869190
chr11:28013510
chr17:40367149
chr17:40359330
chr17:40358936
chr1:10363946
chr17:4868723
chr5:137549287
chr5:137549636
chr5:137546793
chr10:91487558
chr10:91504280
chr10:91493568
chr10:91488022
chr10:91488043
chr12:38031931
chr12:38013324
chr12:38046539
chr12:38020319
chr12:37987750
chr12:37973565
chr12:37974360
chr1:199235186
chr15:67526277
chr15:67514877
chr15:67532211
chr15:67532212
chr15:67532214
chr5:61689727
chr5:61717821
chr5:132065690
chr20:30384767
chr10:32338719
chr10:32339710
chr10:7841859
chr8:103731200
chr8:103731343
chr13:73167108
chr15:29454013
chr15:29455786
chr15:29457236
chr15:29457263
chr19:1804264
chr19:1804529
chr19:1805253
chr7:129559247
chr14:49311100
chr14:49316786
chr1:888604
chr3:47360511
chr3:47360584
chr4:166454680
chr1:6573482
chr1:6573627
chr5:136981207
chr16:83253321
chr16:83258266
chr3:184694758
chr7:23131991
chr9:21321754
chr2:48592111
chr2:48595587
chr12:121653180
chr12:121623642
chr12:121638256
chr12:121676788
chr13:49204900
chr13:49171943
chr3:161696147
chr1:32405361
chr1:32409450
chr2:88108978
chr2:88109082
chr2:88109135
chr7:91680450
chr12:74183976
chr12:74186446
chr12:74186445
chr17:36228026
chr12:50928679
chr1:153408534
chr17:22952550
chr17:22956639
chr17:22974697
chr17:22975111
chr3:120694659
chr14:55148640
chr14:55220660
chr22:39939871
chr8:71732643
chr12:6754912

KIAA2026
KIDINS220
KIDINS220
KIF11
KIF11
KIF15
KIF18A
KIF18B
KIF18B
KIF18B
KIF1B
KIF1C
KIF20A
KIF20A
KIF20A
KIF20B
KIF20B
KIF20B
KIF20B
KIF20B
KIF21A
KIF21A
KIF21A
KIF21A
KIF21A
KIF21A
KIF21A
KIF21B
KIF23
KIF23
KIF23
KIF23
KIF23
KIF2A
KIF2A
KIF3A
KIF3B
KIF5B
KIF5B
KIN
KLF10
KLF10
KLF12
KLF13
KLF13
KLF13
KLF13
KLF16
KLF16
KLF16
KLHDC10
KLHDC2
KLHDC2
KLHL17
KLHL18
KLHL18
KLHL2
KLHL21
KLHL21
KLHL3
KLHL36
KLHL36
KLHL6
KLHL7
KLHL9
KLRAQ1
KLRAQ1
KNTC1
KNTC1
KNTC1
KNTC1
KPNA3
KPNA3
KPNA4
KPNA6
KPNA6
KRCC1
KRCC1
KRCC1
KRIT1
KRR1
KRR1
KRR1
KRT10
KRT7
KRTCAP2
KSR1
KSR1
KSR1
KSR1
KTELC1
KTN1
KTN1
L3MBTL2
LACTB2
LAG3

mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
mixed
UTR3
coding_exon
mixed
mixed
UTR3
mixed
UTR3
UTR3
coding_exon
UTR3
mixed
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
mixed
mixed
mixed
mixed
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon

ENST00000256707:StoY;ENST00000418530:StoY;ENST00000427284:StoY;ENST0000
ENST00000256707:DtoH;ENST00000418530:DtoH;ENST00000427284:DtoH;ENST00
ENST00000260731:ItoV;
ENST00000326047:EtoK;ENST00000425755:EtoK;
ENST00000263181:StoT;
ENST00000339151:LtoR;ENST00000376982:LtoR;ENST00000438933:LtoR;

ENST00000394894:StoC;
ENST00000394894:QtoR;
ENST00000394894:PtoR;
ENST00000260753:TtoP;ENST00000371728:TtoP;ENST00000394289:TtoP;ENST000
ENST00000260753:DtoG;ENST00000371728:DtoG;ENST00000394289:DtoG;ENST00
ENST00000260753:DtoE;ENST00000371728:DtoE;ENST00000394289:DtoE;ENST000

ENST00000341813:StoP;ENST00000361418:StoP;ENST00000361961:StoP;ENST000
ENST00000341813:QtoR;ENST00000361418:QtoR;ENST00000361961:QtoR;ENST00
ENST00000341813:NtoK;ENST00000361418:NtoK;ENST00000361961:NtoK;ENST00
ENST00000341813:HtoR;ENST00000361418:HtoR;ENST00000361961:HtoR;ENST00

ENST00000332129:EtoG;
ENST00000260363:VtoG;ENST00000352331:VtoG;

ENST00000230731:QtoR;ENST00000381103:QtoR;ENST00000401507:QtoR;ENST00

ENST00000298307:VtoE;

ENST00000341319:KtoE;

ENST00000333479:TtoP;ENST00000436959:TtoP;

ENST00000373625:VtoG;

ENST00000229214:FtoS;
ENST00000229214:AtoT;ENST00000438169:AtoT;
ENST00000229214:AtoG;ENST00000438169:AtoG;

ENST00000334975:QtoK;ENST00000356229:QtoK;ENST00000395308:QtoK;ENST00

ENST00000203629:TtoP;ENST00000441671:TtoP;

87

+
+
+

+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+

+
+
+
+

+
+
+
+
+
+
+

+
+

+
+
+
+
+
+

+
+

+
+
+
+
+
+
+
+

AtoG
CtoA
GtoC
AtoG
AtoC
GtoA
GtoC
TtoG
AtoG
AtoC
TtoG
GtoA
CtoG
AtoG
CtoG
AtoC
AtoG
TtoA
GtoT
TtoC
TtoC
AtoG
TtoG
AtoG
TtoC
AtoG
CtoA
AtoG
TtoG
TtoC
CtoG
CtoG
CtoT
AtoG
TtoC
TtoC
TtoG
AtoG
TtoG
TtoC
CtoT
AtoG
TtoC
TtoC
TtoG
TtoA
AtoG
TtoG
TtoG
CtoG
GtoT
TtoA
AtoG
TtoG
AtoG
TtoC
TtoG
GtoA
AtoC
TtoC
GtoA
TtoA
AtoG
TtoC
AtoG
GtoA
TtoC
AtoC
GtoA
TtoA
TtoA
TtoA
GtoA
TtoC
TtoG
TtoC
TtoC
AtoC
AtoT
AtoG
TtoC
GtoA
CtoG
TtoA
TtoG
AtoG
TtoC
TtoC
AtoG
AtoG
TtoA
CtoA
TtoG
TtoA
AtoG
AtoC

0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.1429
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1154
0.1
0.2222
0.2
0.1034
0.1
0.125
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1053
0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1304
0.1
0.1
0.1
0.1
0.1
0.4483
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1333
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1364

0.1
0.1
0.1
0.1176
0.1053
0.2143
0.2
0.1111
0.2
0.1111
0.1429
0.2143
0.1
0.1429
0.1
0.1667
0.1176
0.1818
0.1
0.1176
0.1
0.2
0.125
0.1
0.1
0.1
0.1
0.1
0.2
0.1429
0.6
0.5
0.2
0.1
0.1818
0.2
0.1333
0.2
0.2
0.1
0.1538
0.1905
0.1
0.1429
0.1053
0.129
0.1304
0.1
0.1538
0.2308
0.1
0.1
0.1
0.1
0.1
0.1111
0.1429
0.1667
0.1
0.1
0.1333
0.1176
0.1
0.1538
0.1053
0.1
0.2
0.1875
0.1
0.1176
0.1538
0.2
0.5625
0.1
0.1818
0.1
0.1111
0.25
0.1
0.1
0.1765
0.1875
0.1333
0.1429
0.1667
0.3125
0.4167
0.15
0.1
0.2
0.25
0.1053
0.1053
0.1429
0.1333
0.1379

3
2
3
2
3
2
2
3
3
3
2
3
2
5
3
2
2
4
2
3
2
6
3
2
3
2
2
2
4
4
4
5
8
2
8
5
3
4
3
3
2
7
2
10
6
10
5
2
2
4
2
3
2
2
3
6
3
2
2
2
3
5
5
3
2
2
7
2
2
2
2
2
2
2
3
2
3
3
2
2
4
3
4
6
7
5
6
4
2
5
2
7
2
4
2
2

2
2
2
2
2
2
2
2
3
2
2
3
2
2
2
2
2
2
2
2
2
4
2
2
2
2
2
2
3
2
4
3
5
2
3
4
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
3
5
2
2
3
2
3
2
2
2
2

[10,10]
[10,10]
[10,10]
[10,17]
[10,19]
[10,14]
[10,10]
[10,18]
[10,14]
[10,18]
[10,14]
[10,15]
[10,10]
[10,14]
[10,10]
[10,12]
[10,17]
[11,15]
[10,10]
[17,20]
[10,10]
[10,12]
[10,16]
[10,10]
[10,10]
[10,10]
[10,10]
[10,10]
[15,26]
[10,14]
[10,19]
[15,16]
[10,48]
[10,10]
[11,24]
[10,25]
[15,15]
[10,15]
[10,11]
[10,10]
[10,13]
[10,21]
[10,10]
[19,43]
[10,19]
[20,32]
[17,23]
[10,10]
[10,13]
[13,20]
[10,10]
[10,11]
[10,10]
[10,10]
[10,10]
[10,10]
[10,15]
[10,12]
[10,10]
[10,10]
[10,15]
[10,18]
[10,10]
[13,20]
[10,20]
[10,10]
[10,23]
[10,17]
[10,20]
[10,17]
[10,13]
[10,10]
[29,32]
[10,10]
[10,11]
[10,11]
[10,19]
[10,16]
[10,10]
[10,10]
[10,17]
[16,18]
[15,20]
[10,20]
[12,15]
[11,16]
[11,19]
[10,20]
[10,10]
[10,20]
[10,12]
[20,76]
[10,19]
[10,14]
[10,15]
[22,29]

TableS10

chr19:59557461
LAIR1
chr1:181353293
LAMC1
chr1:181380527
LAMC1
chr3:184324696
LAMP3
chr1:30977905
LAPTM5
chr1:30977912
LAPTM5
chr1:30978575
LAPTM5
chr5:154173702
LARP1
chr5:154174105
LARP1
chr5:154174106
LARP1
chr5:154175469
LARP1
chr5:154176265
LARP1
chr5:154177172
LARP1
chr12:49107814
LARP4
chr12:49107815
LARP4
chr10:846092
LARP4B
chr4:113788295
LARP7
chr4:113793691
LARP7
chr5:145489883
LARS
chr3:45534442
LARS2
chr3:45564417
LARS2
chr17:34328812
LASP1
chr17:34331547
LASP1
chr19:8181744
LASS4
chr2:169339599
LASS6
chr1:223678358
LBR
chr1:223656148
LBR
chr15:41408221
LCMT2
chr13:45630661
LCP1
chr5:169608317
LCP2
chr5:169608315
LCP2
chr10:103858777
LDB1
chr10:103858776
LDB1
chr10:103870090
LDB1
chr11:18377641
LDHA
chr11:18377652
LDHA
chr11:18385970
LDHA
chr11:18385971
LDHA
chr11:18385972
LDHA
chr12:21679544
LDHB
chr12:21679546
LDHB
chr19:11103991
LDLR
chr12:63920063
LEMD3
chr12:63918816
LEMD3
chr12:63850681
LEMD3
chr12:63926554
LEMD3
chr19:60294099
LENG3
chr19:59658518
LENG8
chr19:59664777
LENG8
chr19:59652262
LENG8
chr15:50045844
LEO1
chr15:50045713
LEO1
chr1:42993246
LEPRE1
chr3:191195925
LEPREL1
chr8:30081372
LEPROTL1
chr8:30083834
LEPROTL1
chr8:30084741
LEPROTL1
chr4:1812996
LETM1
chr4:1813173
LETM1
chr4:1813257
LETM1
chr12:49732207
LETMD1
chr22:36405751
LGALS1
chr22:36405752
LGALS1
chr22:36401596
LGALS1
chr22:36401597
LGALS1
chr14:54681755
LGALS3
chr1:234778153
LGALS8
chr1:234780604
LGALS8
chr1:204831661
LGTN
chr1:204831675
LGTN
chr5:77820329
LHFPL2
chr4:39141595
LIAS
chr4:39141600
LIAS
chr4:39149312
LIAS
chr19:53346407
LIG1
chr19:53310547
LIG1
chr17:30348953
LIG3
chr17:30343100
LIG3
chr17:30334205
LIG3
chr17:30340763
LIG3
chr17:30355645
LIG3
chr12:48857996
LIMA1
chr12:48855949
LIMA1
chr12:48856854
LIMA1
chr20:61838489
LIME1
chr7:73173273
LIMK1
chr7:73174283
LIMK1
chr22:29985175
LIMK2
chr14:73735481
LIN52
chr10:91152641
LIPA
chr16:11550849
LITAF
chr16:11549965
LITAF
chr1:144212896
LIX1L
chr22:21003526 22NC0380A10
chr22:21003534 22NC0380A10
chr12:64803960
LLPH

UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
mixed
UTR3
UTR5
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
mixed
UTR5
coding_exon
coding_exon
coding_exon
mixed
coding_exon
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR5
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
mixed
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR5
coding_exon
UTR3
coding_exon
UTR3
coding_exon
mixed
UTR3
UTR3
mixed
mixed
coding_exon

ENST00000265598:VtoA;ENST00000466939:VtoA;

ENST00000324052:DtoA;ENST00000344442:DtoA;
ENST00000324052:AtoS;ENST00000344442:AtoS;
ENST00000394434:VtoG;
ENST00000265537:Wto*;ENST00000414984:Wto*;ENST00000415258:Wto*;

ENST00000305641:YtoD;
ENST00000323076:StoA;ENST00000398576:StoA;
ENST00000046794:YtoD;
ENST00000361198:PtoH;ENST00000419270:PtoH;ENST00000425280:PtoH;

ENST00000227157:LtoI;ENST00000379412:LtoI;ENST00000396222:LtoI;ENST00000

ENST00000308330:VtoA;
ENST00000308330:RtoS;

ENST00000301196:StoP;ENST00000326764:StoP;ENST00000376526:StoP;ENST000

ENST00000299601:GtoR;ENST00000315141:GtoR;
ENST00000236040:Sto*;ENST00000296388:Sto*;
ENST00000321250:LtoH;ENST00000442880:LtoH;

ENST00000302787:VtoG;
ENST00000302787:VtoG;
ENST00000302787:LtoP;
ENST00000262055:NtoD;ENST00000418425:NtoD;ENST00000448283:NtoD;

ENST00000261434:YtoS;ENST00000340169:YtoS;ENST00000381846:YtoS;ENST0000
ENST00000261434:TtoP;ENST00000340169:TtoP;ENST00000381846:TtoP;ENST000

ENST00000262327:VtoA;ENST00000378526:VtoA;
ENST00000262327:NtoD;ENST00000378526:NtoD;
ENST00000262327:LtoQ;ENST00000378526:LtoQ;
ENST00000262327:ItoT;ENST00000378526:ItoT;

ENST00000336180:YtoF;ENST00000418310:YtoF;

ENST00000266604:KtoT;

88

+
+

+
+
+
+
+
+
+
+

+
+

+
+
+
+
+
+

+
+
+
+
+

+
+
+
+
+

+
+
+

+
+
+

+
+
+
+
+
+
+
+

+
+
+

+
+
+
+
+

+
+
+
+
+

+
+
+

CtoA
AtoG
TtoA
TtoC
TtoA
AtoG
TtoA
TtoG
GtoA
GtoA
TtoG
AtoG
AtoG
GtoT
GtoT
AtoG
AtoC
GtoT
TtoG
GtoA
TtoG
AtoG
GtoA
GtoC
AtoG
CtoA
TtoC
TtoG
TtoG
TtoG
CtoT
CtoA
TtoG
GtoA
CtoA
AtoG
AtoG
CtoA
TtoA
TtoC
TtoC
AtoC
TtoC
CtoA
TtoC
TtoC
CtoA
TtoC
TtoA
TtoG
GtoA
TtoA
CtoG
CtoG
TtoA
GtoA
GtoT
TtoG
TtoG
TtoC
AtoG
CtoG
TtoG
TtoC
CtoA
AtoG
GtoA
TtoC
AtoG
TtoA
AtoG
AtoC
AtoC
TtoC
AtoG
TtoC
TtoC
AtoG
TtoA
TtoC
TtoA
AtoG
AtoG
TtoC
GtoA
AtoT
CtoT
TtoC
TtoC
AtoG
TtoC
TtoC
AtoG
CtoG
TtoC
AtoC

0.15
0.1
0.1
0.12
0.3
0.1
0.1117
0.1053
0.1026
0.1
0.1957
0.1429
0.1034
0.1538
0.1
0.1
0.1
0.1053
0.1042
0.1
0.1
0.141
0.2
0.1818
0.1
0.1
0.1
0.1
0.1053
0.125
0.1333
0.1053
0.1
0.1
0.1429
0.1029
0.1045
0.5455
0.75
0.125
0.1
0.1176
0.1
0.1
0.1
0.1
0.1
0.1364
0.1
0.1
0.1333
0.1
0.1667
0.1
0.1
0.1
0.1
0.125
0.1
0.1053
0.1
0.16
0.3
0.1111
0.125
0.1
0.1053
0.1
0.1
0.125
0.1176
0.1429
0.1538
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
1
0.375
0.1
0.1053
0.1
0.1
0.1071
0.1
0.4667
0.25
0.1009

0.4444
0.1
0.1
0.1212
0.4444
0.1846
0.1643
0.1385
0.25
0.1538
0.2222
0.2
0.1538
0.1765
0.1667
0.1
0.1
0.1333
0.1875
0.1
0.1
0.1765
0.5455
0.25
0.1
0.1
0.1212
0.2
0.125
0.1579
0.15
0.15
0.1905
0.25
0.1429
0.144
0.3478
1
0.8333
0.1429
0.3333
0.1429
0.1333
0.1
0.1
0.1
0.1667
0.1667
0.1
0.125
0.2
0.1538
0.2727
0.2
0.1111
0.1
0.1
0.1538
0.1852
0.1111
0.1818
0.2727
0.5
0.1786
0.1538
0.1667
0.1875
0.1053
0.2727
0.1818
0.125
0.1667
0.2222
0.1
0.1282
0.14
0.1
0.1
0.2
0.1
0.1
0.1
0.1818
0.1
0.1
1
0.5
0.1429
0.125
0.2143
0.1149
0.1818
0.1818
0.8438
0.5714
0.102

3
3
2
9
3
15
12
2
10
10
3
5
9
3
3
5
2
4
7
3
4
4
6
3
2
2
10
2
2
2
2
8
9
2
7
12
10
12
4
5
6
5
2
2
2
3
2
3
3
3
4
3
2
3
4
2
3
2
6
3
2
4
3
2
2
5
5
2
12
9
4
2
5
2
4
7
3
2
3
2
3
4
5
3
3
13
2
2
3
3
9
10
5
2
2
8

3
2
2
2
3
13
3
2
4
3
2
2
3
2
3
3
2
2
4
2
2
3
6
3
2
2
5
2
2
2
2
5
4
2
2
7
10
12
4
2
3
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
3
2
2
2
4
2
6
3
2
2
2
2
2
3
2
2
2
2
2
2
2
2
3
13
2
2
2
2
2
3
3
2
2
2

[18,24]
[10,10]
[10,10]
[25,33]
[10,10]
[65,567]
[149,191]
[19,65]
[12,40]
[13,23]
[19,48]
[15,20]
[13,29]
[13,17]
[10,16]
[10,10]
[10,10]
[15,19]
[16,48]
[10,10]
[10,10]
[51,81]
[10,14]
[10,12]
[10,10]
[10,20]
[20,36]
[10,10]
[19,24]
[16,19]
[15,20]
[19,54]
[21,57]
[10,12]
[21,100]
[24,153]
[42,298]
[11,75]
[13,24]
[14,16]
[10,12]
[14,17]
[10,15]
[10,10]
[10,10]
[10,10]
[10,12]
[18,22]
[10,10]
[10,16]
[10,15]
[10,13]
[11,12]
[10,27]
[10,10]
[10,10]
[10,10]
[13,16]
[10,27]
[18,19]
[10,11]
[11,26]
[10,16]
[10,28]
[13,17]
[10,12]
[16,25]
[10,19]
[11,18]
[11,32]
[16,17]
[12,14]
[13,18]
[10,10]
[30,39]
[10,50]
[10,10]
[10,10]
[10,10]
[10,10]
[10,10]
[10,20]
[10,11]
[10,20]
[10,10]
[11,80]
[56,74]
[10,14]
[16,19]
[10,14]
[87,121]
[11,29]
[10,11]
[15,64]
[14,16]
[49,109]

TableS10

chr12:64804041
chr12:64803612
chr18:55147922
chr5:176691179
chr5:176691627
chr2:96736499
chr2:96736677
chr7:156169603
chr6:70485601
chr3:8553937
chr11:33837092
chr1:87583556
chr5:96341273
chr5:96395815
chr5:96398142
chr19:5670776
chr16:46843599
chr16:46943219
chr16:46943360
chr19:19596300
chr5:1514542
chr15:32443698
chr1:210023225
chr1:209985691
chr1:209986229
chr1:209986988
chr1:209988099
chr1:209988748
chr18:2929544
chr18:2908112
chr18:2909346
chr11:58051340
chr4:151948934
chr4:151406265
chr13:46223076
chr13:46223596
chr3:199043543
chr3:199026319
chr3:199087040
chr3:199097094
chr12:25096958
chr2:44054452
chr2:44055355
chr2:43980230
chr2:44041215
chr2:43969172
chr10:71728983
chr10:71729562
chr15:97613726
chr15:97719067
chr15:97720977
chr15:97719073
chr1:46524047
chr1:3686917
chr15:40624714
chr17:45815211
chr7:149659721
chr7:149659747
chr9:130710186
chr9:130710916
chr9:130719991
chr1:90171563
chr1:90172282
chr2:238333477
chr3:37071635
chr3:37070265
chr15:99423272
chr15:99406355
chr15:99427163
chr9:129275915
chr9:129257126
chr7:101900568
chr8:38140179
chr19:39410718
chr19:39411221
chr19:39411976
chr20:60142724
chr20:60142852
chr20:60142853
chr6:31873169
chr6:31873171
chr4:147330401
chr11:1870029
chr11:1870054
chr21:46453962
chr6:31650059
chr6:31650060
chr6:31650061
chr12:94947080
chr12:94918892
chr6:31656353
chr6:144225056
chr16:210649
chr16:217335
chr7:138758324
chr7:138758395

LLPH
LLPH
LMAN1
LMAN2
LMAN2
LMAN2L
LMAN2L
LMBR1
LMBRD1
LMCD1
LMO2
LMO4
LNPEP
LNPEP
LNPEP
LONP1
LONP2
LONP2
LONP2
LPAR2
LPCAT1
LPCAT4
LPGAT1
LPGAT1
LPGAT1
LPGAT1
LPGAT1
LPGAT1
LPIN2
LPIN2
LPIN2
LPXN
LRBA
LRBA
LRCH1
LRCH1
LRCH3
LRCH3
LRCH3
LRCH3
LRMP
LRPPRC
LRPPRC
LRPPRC
LRPPRC
LRPPRC
LRRC20
LRRC20
LRRC28
LRRC28
LRRC28
LRRC28
LRRC41
LRRC47
LRRC57
LRRC59
LRRC61
LRRC61
LRRC8A
LRRC8A
LRRC8A
LRRC8D
LRRC8D
LRRFIP1
LRRFIP2
LRRFIP2
LRRK1
LRRK1
LRRK1
LRSAM1
LRSAM1
LRWD1
LSM1
LSM14A
LSM14A
LSM14A
LSM14B
LSM14B
LSM14B
LSM2
LSM2
LSM6
LSP1
LSP1
LSS
LTA
LTA
LTA
LTA4H
LTA4H
LTB
LTV1
LUC7L
LUC7L
LUC7L2
LUC7L2

coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR5
UTR5
coding_exon
coding_exon
UTR3
mixed
mixed
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR3

ENST00000266604:ItoT;

ENST00000316198:HtoP;ENST00000347571:HtoP;ENST00000353442:HtoP;ENST00
ENST00000370570:VtoL;ENST00000370577:VtoL;

ENST00000231368:AtoD;ENST00000379870:AtoD;ENST00000395770:AtoD;ENST00

ENST00000358403:HtoP;ENST00000360614:HtoP;
ENST00000285737:HtoR;ENST00000416006:HtoR;

ENST00000407877:LtoP;
ENST00000314891:KtoE;

ENST00000357115:VtoA;

ENST00000334859:YtoN;ENST00000414675:YtoN;ENST00000425562:YtoN;ENST00
ENST00000334859:StoC;ENST00000414675:StoC;ENST00000425562:StoC;ENST000

ENST00000260665:LtoP;ENST00000409659:LtoP;ENST00000409946:LtoP;
ENST00000260665:DtoG;ENST00000409659:DtoG;ENST00000409946:DtoG;

ENST00000301981:LtoR;ENST00000331450:LtoR;ENST00000422500:LtoR;ENST000
ENST00000301981:CtoW;ENST00000422500:CtoW;ENST00000447360:CtoW;ENST0
ENST00000301981:AtoS;ENST00000422500:AtoS;ENST00000450058:AtoS;
ENST00000254454:StoP;ENST00000343304:StoP;ENST00000371972:StoP;

ENST00000259324:YtoN;ENST00000372599:YtoN;ENST00000372600:YtoN;
ENST00000259324:LtoH;ENST00000372599:LtoH;ENST00000372600:LtoH;

ENST00000244815:AtoV;ENST00000289175:AtoV;ENST00000308482:AtoV;ENST00

ENST00000284395:StoA;ENST00000388948:StoA;
ENST00000284395:LtoR;ENST00000388948:LtoR;
ENST00000300417:YtoN;ENST00000323301:YtoN;ENST00000373322:YtoN;ENST00
ENST00000300417:LtoP;ENST00000323301:LtoP;ENST00000373322:LtoP;ENST0000

ENST00000367576:DtoG;
ENST00000293872:DtoE;ENST00000337351:DtoE;ENST00000397780:DtoE;ENST000

89

+
+
+
+

+
+
+

+
+
+
+
+
+
+

+
+
+
+

+
+
+
+
+
+
+
+

+
+
+
+
+
+

+
+
+
+
+
+

+
+
+

+
+
+

+
+

TtoC
AtoG
AtoG
AtoG
AtoG
TtoC
TtoG
AtoC
GtoT
TtoC
AtoG
TtoA
CtoA
TtoC
TtoG
AtoC
AtoG
AtoG
TtoA
TtoC
AtoG
AtoG
AtoC
TtoC
TtoC
TtoC
TtoG
AtoT
GtoA
TtoG
GtoA
TtoG
TtoC
TtoA
AtoC
AtoG
TtoA
AtoT
TtoC
AtoG
AtoG
TtoC
AtoG
AtoG
AtoG
TtoC
TtoG
GtoT
TtoG
TtoG
GtoT
TtoC
TtoC
AtoG
CtoA
TtoC
AtoG
AtoG
TtoA
TtoA
TtoC
TtoC
AtoG
CtoT
AtoG
TtoG
TtoG
TtoG
GtoT
TtoA
TtoC
TtoG
TtoA
GtoA
CtoT
TtoG
AtoG
CtoA
AtoG
TtoA
AtoG
AtoG
AtoC
TtoC
CtoG
AtoG
AtoG
TtoA
GtoA
TtoC
AtoC
AtoG
TtoG
AtoT
TtoG
TtoA

0.1
0.1333
0.1429
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1667
0.1
0.1111
0.1
0.1
0.1
0.1034
0.1
0.1111
0.1111
0.1
0.1
0.1
0.1
0.1
0.2308
0.1
0.1
0.1
0.1818
0.1
0.1
0.1429
0.125
0.1818
0.1
0.1
0.1111
0.1071
0.1
0.125
0.1
0.1
0.1
0.125
0.1
0.1
0.1
0.1154
0.1
0.1
0.1111
0.1
0.1
0.1
0.1818
0.1
0.1
0.1081
0.1667
0.1
0.1
0.1429
0.375
0.1
0.1
0.1
0.1
0.1
0.125
0.1
0.1304
0.1
0.1667
0.1053
0.1
0.1
0.1071
0.1077
0.125
0.1024
0.1071
0.1
0.1111
0.1111
0.1
0.1429
0.1053
0.1111
0.125
0.1

0.2258
0.2
0.2
0.1333
0.1667
0.1
0.1
0.1
0.1
0.1667
0.12
0.1765
0.1
0.1
0.1429
0.3571
0.1
0.1333
0.1333
0.1
0.1333
0.1333
0.1
0.1304
0.125
0.1
0.1
0.1
0.1
0.1053
0.2727
0.1724
0.125
0.1538
0.25
0.1053
0.2
0.1538
0.1333
0.3
0.1333
0.1389
0.1429
0.1154
0.3
0.1818
0.1
0.1
0.1
0.2308
0.1429
0.1667
0.1333
0.1818
0.1
0.1333
0.15
0.2143
0.1
0.1
0.2
0.2
0.2
0.1429
0.2
0.1
0.1053
0.2
0.5652
0.1
0.1667
0.1176
0.1
0.1
0.2
0.2857
0.1364
0.1
0.1875
0.125
0.1087
0.1
0.1138
0.1087
0.2222
0.2927
0.2222
0.3529
0.1111
0.129
0.1053
0.2222
0.1111
0.3
0.1667
0.1818

11
3
4
4
5
2
3
2
3
3
3
8
2
2
2
4
3
7
3
3
2
4
2
3
7
2
2
2
4
7
2
4
5
5
4
3
4
2
2
2
2
5
3
2
9
7
3
3
2
7
2
3
2
4
2
2
4
6
2
2
3
4
2
2
4
6
4
2
2
2
6
3
4
3
5
6
6
3
4
3
9
2
5
7
3
19
15
13
3
6
2
10
3
11
3
6

5
2
2
2
3
2
2
2
2
2
3
3
2
2
2
2
2
2
2
2
2
3
2
2
3
2
2
2
2
3
2
3
3
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
3
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
3
2
2
2
2
3
2
2
2
2
4
2
2
2
2
4
2
2
2
2
16
5
10
2
2
2
3
2
7
2
3

[18,62]
[10,15]
[20,21]
[11,16]
[11,18]
[10,10]
[10,10]
[10,10]
[10,10]
[10,12]
[10,25]
[10,22]
[10,10]
[10,10]
[14,17]
[15,18]
[10,10]
[15,18]
[10,16]
[10,20]
[10,15]
[16,29]
[10,10]
[18,23]
[16,18]
[10,10]
[10,11]
[10,10]
[10,10]
[10,19]
[11,13]
[20,40]
[10,32]
[10,13]
[11,12]
[10,19]
[10,10]
[13,14]
[15,16]
[11,11]
[10,15]
[20,36]
[14,18]
[26,28]
[10,28]
[16,22]
[10,10]
[10,10]
[10,10]
[13,16]
[10,14]
[10,12]
[10,15]
[11,26]
[10,10]
[15,20]
[18,20]
[10,14]
[10,10]
[10,10]
[10,11]
[10,10]
[10,10]
[35,37]
[18,20]
[10,10]
[10,19]
[15,20]
[23,56]
[10,10]
[10,14]
[10,17]
[10,10]
[10,10]
[15,16]
[10,14]
[22,23]
[10,10]
[12,16]
[16,19]
[20,46]
[10,10]
[58,125]
[46,65]
[17,18]
[20,207]
[10,42]
[10,54]
[18,18]
[27,32]
[10,19]
[10,17]
[19,19]
[10,27]
[12,16]
[10,12]

TableS10

chr1:23292498
chr6:31746732
chr6:31748710
chr2:160458692
chr6:6600206
chr1:159036278
chr1:159036288
chr4:4320533
chr4:4320559
chr1:23994613
chr1:23994615
chr1:217450564
chr16:20843304
chr16:20843735
chr5:130566784
chr1:149401031
chr15:98073610
chr1:9913074
chr22:19672309
chr19:4789352
chr19:4789359
chr1:39591327
chr1:39669016
chr1:39677585
chr1:39681709
chr1:39686147
chr1:39724179
chr1:39724310
chr4:121206413
chr4:121202598
chr4:121200566
chr11:47286772
chr4:1323279
chr4:1323875
chr8:145234484
chr3:185910879
chr1:53465273
chr12:10654520
chr9:87823517
chr1:117786376
chr1:117786377
chr1:117872591
chr9:139116584
chr15:89257111
chr4:6662463
chr15:73438726
chr15:73438724
chr15:73435192
chr4:103804992
chr5:71530066
chr5:71530076
chr19:4052140
chr19:4052246
chr19:4052247
chr19:4053378
chr19:4053405
chr19:4053415
chr19:4068477
chr17:21158633
chr15:65665294
chr15:65849002
chr17:65024636
chr17:65031300
chr19:7883830
chr12:52162236
chr12:52166490
chr3:186486014
chr17:40707646
chr17:40700857
chr17:40696815
chr2:127780650
chr6:161390909
chr6:161422032
chr6:136964708
chr6:136985738
chr22:38214122
chr22:38241623
chr22:38241871
chr22:38242094
chr6:149741482
chr6:149772609
chr6:149773419
chr10:30787136
chr10:30776876
chr3:47933123
chr3:47933226
chr3:47867249
chr3:47868721
chr19:43770125
chr14:49956572
chr1:36410676
chr22:20446301
chr22:20446750
chr22:49045097
chr22:49033475
chr6:36186470

LUZP1
LY6G5B
LY6G5B
LY75
LY86
LY9
LY9
LYAR
LYAR
LYPLA2
LYPLA2
LYPLAL1
LYRM1
LYRM1
LYRM7
LYSMD1
LYSMD4
LZIC
LZTR1
M6PRBP1
M6PRBP1
MACF1
MACF1
MACF1
MACF1
MACF1
MACF1
MACF1
MAD2L1
MAD2L1
MAD2L1
MADD
MAEA
MAEA
MAF1
MAGEF1
MAGOH
MAGOHB
MAK10
MAN1A2
MAN1A2
MAN1A2
MAN1B1
MAN2A2
MAN2B2
MAN2C1
MAN2C1
MAN2C1
MANBA
MAP1B
MAP1B
MAP2K2
MAP2K2
MAP2K2
MAP2K2
MAP2K2
MAP2K2
MAP2K2
MAP2K3
MAP2K5
MAP2K5
MAP2K6
MAP2K6
MAP2K7
MAP3K12
MAP3K12
MAP3K13
MAP3K14
MAP3K14
MAP3K14
MAP3K2
MAP3K4
MAP3K4
MAP3K5
MAP3K5
MAP3K7IP1
MAP3K7IP1
MAP3K7IP1
MAP3K7IP1
MAP3K7IP2
MAP3K7IP2
MAP3K7IP2
MAP3K8
MAP3K8
MAP4
MAP4
MAP4
MAP4
MAP4K1
MAP4K5
MAP7D1
MAPK1
MAPK1
MAPK11
MAPK12
MAPK14

coding_exon
mixed
UTR3
coding_exon
UTR3
mixed
mixed
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
mixed
coding_exon
coding_exon
UTR3
UTR3
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
mixed
UTR3
coding_exon
coding_exon
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR5
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3

ENST00000314174:NtoD;ENST00000374623:NtoD;ENST00000418342:NtoD;

ENST00000263636:WtoG;ENST00000409803:WtoG;ENST00000409827:WtoG;

ENST00000343470:VtoA;ENST00000452476:VtoA;

ENST00000368908:WtoS;ENST00000440902:WtoS;

ENST00000296509:ItoV;ENST00000333047:ItoV;

ENST00000311027:ItoV;ENST00000342922:ItoV;ENST00000349238:ItoV;ENST0000

ENST00000320756:NtoD;ENST00000381881:NtoD;

ENST00000360468:PtoA;ENST00000431652:NtoK;
ENST00000285599:StoP;
ENST00000267978:QtoP;
ENST00000267978:EtoK;

ENST00000296755:StoA;
ENST00000296755:QtoR;
ENST00000262948:DtoE;ENST00000394867:DtoE;ENST00000443189:DtoE;

ENST00000178640:PtoH;ENST00000395476:PtoH;
ENST00000359094:NtoK;
ENST00000359094:CtoR;
ENST00000267079:QtoR;ENST00000444144:QtoR;
ENST00000267079:KtoR;ENST00000444144:KtoR;
ENST00000344686:PtoR;

ENST00000348824:LtoI;ENST00000366919:LtoI;ENST00000366920:LtoI;ENST00000
ENST00000348824:Gto*;ENST00000366919:Gto*;ENST00000366920:Gto*;ENST00
ENST00000355845:CtoR;ENST00000359015:CtoR;

ENST00000263056:YtoN;ENST00000375321:YtoN;ENST00000375328:YtoN;
ENST00000263056:CtoS;ENST00000375321:CtoS;ENST00000375328:CtoS;
ENST00000360240:KtoE;ENST00000395734:KtoE;ENST00000403918:KtoE;

ENST00000013125:VtoD;ENST00000429500:VtoD;
ENST00000316156:EtoG;ENST00000373150:EtoG;ENST00000373151:EtoG;

90

+
+

+
+
+

+
+
+
+
+
+

+
+
+
+
+
+
+

+
+
+
+

+
+
+
+
+
+
+

+
+

+
+
+
+
+
+

+
+

+
+
+
+
+
+
+
+
+

AtoG
TtoA
AtoG
TtoG
TtoC
TtoG
TtoC
TtoC
TtoC
TtoC
AtoG
AtoG
TtoA
TtoC
TtoC
GtoC
TtoC
AtoG
TtoC
TtoA
AtoG
TtoC
TtoC
TtoC
AtoG
GtoA
TtoC
TtoC
AtoG
CtoT
AtoG
AtoG
TtoC
TtoA
TtoA
TtoC
TtoG
AtoG
AtoG
AtoG
TtoG
CtoG
GtoA
CtoG
TtoC
AtoC
GtoA
TtoC
GtoA
TtoG
AtoG
TtoG
GtoC
AtoT
TtoC
CtoT
AtoG
CtoG
TtoC
CtoA
CtoG
TtoG
TtoC
CtoA
AtoG
AtoG
AtoC
CtoG
AtoC
AtoC
TtoG
TtoA
GtoT
TtoC
TtoC
AtoC
TtoC
TtoC
TtoC
AtoG
TtoC
AtoT
TtoA
TtoA
AtoG
CtoT
TtoC
AtoG
TtoC
TtoA
AtoG
TtoA
AtoG
AtoG
AtoC
TtoC

0.1
0.1333
0.1
0.1
0.1429
0.1
0.1765
0.1
0.1
0.1176
0.1667
0.1
0.1
0.1176
0.1
0.1111
0.1
0.1
0.1
0.2
0.1
0.1
0.1
0.1163
0.1111
0.1
0.1
0.1
0.1053
0.129
0.1
0.1
0.1176
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.2308
0.1
0.2
0.1
0.1
0.1364
0.125
0.1
0.1818
0.1
0.1429
0.125
0.1
0.1053
0.1
0.1
0.9855
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1818
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1154
0.1053
0.1
0.1
0.1111
0.1667
0.1
1
0.1
0.1034

0.2
0.2
0.1333
0.1
0.1875
0.125
0.2143
0.1364
0.1111
0.1818
0.4118
0.1667
0.1429
0.1538
0.1
0.1333
0.1
0.1
0.1
0.4
0.1667
0.1429
0.1538
0.1429
0.125
0.1
0.2
0.1176
0.2
0.1429
0.1
0.1
0.1538
0.2308
0.1111
0.1765
0.1429
0.1667
0.1429
0.1818
0.2
0.2
0.3333
0.2381
0.2143
0.4375
0.4118
0.1538
0.1429
0.2
0.2727
0.2
0.1875
0.1667
0.1875
0.12
0.125
0.1667
1
0.1
0.1
0.1
0.125
0.1538
0.1
0.2
0.1
0.1579
0.2
0.1176
0.1
0.1111
0.1
0.1538
0.1429
0.1
0.1
0.1
0.1429
0.1
0.1667
0.1111
0.1053
0.1
0.1538
0.1333
0.1875
0.1111
0.1429
0.1667
0.1818
0.2
0.1111
1
0.1
0.1818

2
4
5
3
7
2
5
3
5
2
2
6
5
5
2
2
7
3
2
3
9
4
5
4
5
2
4
3
2
2
3
5
2
5
3
8
3
3
6
7
7
3
4
11
4
13
14
8
3
2
2
5
7
7
6
5
7
4
7
2
2
3
2
2
3
3
2
3
3
2
2
2
2
3
7
2
7
2
3
2
5
4
2
4
3
4
4
2
7
2
3
4
2
5
2
4

2
2
2
2
4
2
2
3
2
2
2
2
3
2
2
2
2
2
2
3
3
2
2
2
2
2
4
2
2
2
2
2
2
3
2
2
2
2
2
3
3
2
4
4
2
5
9
2
2
2
2
2
3
4
2
2
2
2
7
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
3
2
2
3
2
5
2
2

[10,15]
[10,15]
[10,15]
[10,10]
[13,18]
[10,16]
[14,17]
[10,22]
[10,28]
[11,18]
[12,18]
[10,12]
[10,18]
[13,18]
[10,10]
[15,18]
[10,21]
[10,10]
[10,10]
[10,16]
[12,20]
[10,14]
[10,13]
[14,43]
[18,24]
[10,30]
[10,14]
[10,17]
[10,21]
[21,31]
[10,10]
[10,10]
[13,17]
[10,14]
[10,10]
[10,17]
[14,20]
[18,30]
[14,19]
[10,17]
[10,15]
[10,10]
[10,13]
[13,30]
[10,14]
[10,41]
[10,40]
[13,22]
[14,16]
[10,10]
[11,11]
[10,16]
[14,29]
[13,32]
[10,16]
[19,25]
[10,24]
[22,42]
[33,95]
[10,10]
[10,10]
[10,10]
[10,16]
[10,13]
[10,10]
[10,10]
[10,10]
[10,19]
[10,11]
[10,17]
[10,10]
[10,10]
[10,10]
[10,13]
[10,14]
[10,10]
[10,40]
[10,10]
[10,14]
[10,10]
[10,12]
[10,18]
[10,19]
[10,10]
[10,13]
[15,30]
[16,26]
[18,19]
[14,52]
[10,12]
[11,28]
[10,13]
[10,18]
[10,24]
[10,10]
[11,29]

TableS10

chr14:54602467
chr14:54602521
chr14:54602612
chr14:54605342
chr14:54605345
chr10:49313993
chr11:45881281
chr11:45883304
chr11:45882142
chr11:45880140
chr11:45880523
chr11:45880558
chr11:45881530
chr11:45881557
chr11:45880527
chr11:45881061
chr11:45881496
chr11:45882260
chr11:45882589
chr11:45883850
chr11:45883852
chr11:45884222
chr16:1737031
chr16:1760315
chr5:179640085
chr5:179595731
chr5:179595748
chr1:204974220
chr3:50654736
chr3:50660403
chr15:39905561
chr15:39978456
chr15:39978996
chr15:39979009
chr4:101021807
chr18:30904171
chr19:8409531
chr5:126281743
chr5:10430983
chr5:10483116
chr5:10458684
chr2:160312953
chr2:160332097
chr2:160332113
chr10:45276756
chr10:45304823
chr10:45271339
chr6:114288609
chr1:32572034
chr14:103039347
chr19:50475799
chr19:50482758
chr19:50498439
chr19:50498508
chr12:56168135
chr1:46273844
chr1:46270459
chr1:46269500
chr1:46270872
chr1:46067775
chr1:46067824
chr19:18102477
chr19:18118825
chr19:18121762
chr10:27499838
chr10:27499985
chr5:162878726
chr5:138639721
chr20:3795190
chr14:64611705
chr18:46051840
chr18:46051843
chr19:1527680
chr3:130634659
chr2:148944034
chr12:56206277
chr12:56206279
chr12:56210097
chr14:35838050
chr3:153664540
chr3:153666160
chr2:8915736
chr3:184237721
chr2:46988482
chr1:148813687
chr10:13253251
chr10:13277053
chr3:128823916
chr21:46491087
chr21:46524474
chr21:46487254
chr21:46528612
chr21:46529734
chr21:46529736
chr21:46530127
chr2:136333433

MAPK1IP1L
MAPK1IP1L
MAPK1IP1L
MAPK1IP1L
MAPK1IP1L
MAPK8
MAPK8IP1
MAPK8IP1
MAPK8IP1
MAPK8IP1
MAPK8IP1
MAPK8IP1
MAPK8IP1
MAPK8IP1
MAPK8IP1
MAPK8IP1
MAPK8IP1
MAPK8IP1
MAPK8IP1
MAPK8IP1
MAPK8IP1
MAPK8IP1
MAPK8IP3
MAPK8IP3
MAPK9
MAPK9
MAPK9
MAPKAPK2
MAPKAPK3
MAPKAPK3
MAPKBP1
MAPKBP1
MAPKBP1
MAPKBP1
MAPKSP1
MAPRE2
MARCH2
MARCH3
MARCH6
MARCH6
MARCH6
MARCH7
MARCH7
MARCH7
MARCH8
MARCH8
MARCH8
MARCKS
MARCKSL1
MARK3
MARK4
MARK4
MARK4
MARK4
MARS
MAST2
MAST2
MAST2
MAST2
MAST2
MAST2
MAST3
MAST3
MAST3
MASTL
MASTL
MAT2B
MATR3
MAVS
MAX
MBD1
MBD1
MBD3
MBD4
MBD5
MBD6
MBD6
MBD6
MBIP
MBNL1
MBNL1
MBOAT2
MCCC1
MCFD2
MCL1
MCM10
MCM10
MCM2
MCM3AP
MCM3AP
MCM3AP
MCM3AP
MCM3AP
MCM3AP
MCM3AP
MCM6

UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR5
mixed
mixed
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
mixed
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
UTR5
UTR5
coding_exon

ENST00000241014:VtoI;ENST00000395629:VtoI;
ENST00000241014:PtoL;ENST00000395629:PtoL;
ENST00000241014:LtoP;ENST00000395629:LtoP;
ENST00000241014:HtoY;ENST00000395629:HtoY;
ENST00000241014:HtoP;ENST00000395629:HtoP;
ENST00000241014:GtoS;ENST00000395629:GtoS;
ENST00000241014:GtoR;ENST00000395629:GtoR;
ENST00000241014:AtoT;ENST00000395629:AtoT;

ENST00000250894:CtoG;ENST00000356010:CtoG;
ENST00000343111:QtoR;ENST00000347470:QtoR;ENST00000393360:QtoR;ENST00

ENST00000357955:HtoP;ENST00000446044:HtoP;

ENST00000300249:VtoG;ENST00000413393:VtoG;ENST00000436190:VtoG;
ENST00000308660:StoI;
ENST00000274140:StoR;
ENST00000274140:LtoH;
ENST00000259050:DtoE;ENST00000409175:DtoE;ENST00000409591:DtoE;
ENST00000259050:*toK;ENST00000409175:*toK;ENST00000409591:*toK;
ENST00000319836:StoP;ENST00000395769:StoP;ENST00000395771:StoP;
ENST00000319836:KtoQ;ENST00000395769:KtoQ;ENST00000395771:KtoQ;

ENST00000262891:TtoP;ENST00000300843:TtoP;
ENST00000262891:TtoN;ENST00000300843:TtoN;

ENST00000361297:PtoH;ENST00000372009:PtoH;ENST00000456625:PtoH;
ENST00000361297:LtoF;ENST00000372009:LtoF;

ENST00000262811:RtoQ;
ENST00000262811:DtoE;

ENST00000355673:TtoI;
ENST00000355673:PtoS;

ENST00000265594:TtoA;ENST00000392616:TtoA;ENST00000492597:TtoA;
ENST00000319466:StoP;ENST00000409105:StoP;ENST00000409147:StoP;ENST000
ENST00000361282:TtoA;ENST00000378694:TtoA;ENST00000378714:TtoA;ENST000

ENST00000291688:StoA;ENST00000397708:StoA;
ENST00000291688:NtoD;ENST00000397708:NtoD;

ENST00000264156:StoP;

91

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+

+
+

+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+

+
+

+
+
+

TtoA
CtoA
TtoC
GtoT
TtoA
TtoG
GtoA
CtoT
TtoC
CtoT
AtoC
GtoA
GtoC
GtoA
CtoT
AtoG
TtoC
GtoA
CtoT
TtoC
TtoC
GtoA
TtoG
TtoC
AtoG
TtoC
TtoC
AtoG
AtoC
TtoA
AtoG
AtoT
GtoA
CtoA
AtoG
TtoG
TtoC
GtoT
TtoA
TtoA
TtoC
TtoA
TtoA
AtoG
TtoC
AtoC
CtoT
TtoG
TtoC
AtoG
AtoC
CtoA
AtoG
AtoG
GtoT
CtoA
GtoT
GtoC
TtoC
TtoC
CtoA
GtoA
TtoG
AtoG
TtoG
TtoA
TtoC
TtoG
TtoC
AtoC
CtoG
AtoC
TtoA
TtoC
AtoG
CtoT
CtoT
TtoG
AtoC
TtoC
AtoG
TtoA
AtoG
TtoC
TtoC
AtoG
GtoA
AtoG
TtoG
AtoG
TtoC
TtoC
TtoG
CtoG
AtoG
TtoC

0.1
0.1
0.1
0.1
0.1
0.1
1
1
0.7
1
0.9231
1
0.8571
0.9524
0.9
1
0.9333
1
0.9706
0.9
0.9
0.9
0.1818
0.1429
0.1
0.1111
0.1
0.1818
0.1
0.1
0.1
0.1053
0.1
0.1667
0.125
0.1111
0.1
0.1
0.1429
0.1
0.1
0.1429
0.1
0.1
0.1
0.1
0.4545
0.102
0.1538
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.125
0.1
0.1
0.1
0.1
0.1667
0.1
0.1
0.1111
0.125
0.1818
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1667
0.1
0.1111
0.1333
0.12
0.1
0.1
0.16
0.1111
0.1
0.125
0.1
0.1
0.1
0.1
0.1

0.1
0.1667
0.1818
0.1
0.125
0.1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
0.2727
0.2308
0.2222
0.2
0.1
0.1818
0.2727
0.1
0.1
0.1818
0.1818
0.4
0.1579
0.1667
0.1111
0.1
0.1538
0.1111
0.1579
0.3
0.1429
0.1
0.1667
0.1
0.75
0.2667
0.3333
0.1538
0.1
0.1
0.1
0.1
0.375
0.1818
0.125
0.2
0.1667
0.2
0.1
0.2
0.25
0.1
0.1
0.1
0.2
0.2308
0.1111
0.16
0.2353
0.1852
0.1818
0.15
0.1818
0.1
0.1538
0.1538
0.1
0.1333
0.2
0.2727
0.125
0.1818
0.1818
0.1
0.1538
0.1667
0.1579
0.1053
0.2
0.1
0.125
0.125
0.1667
0.1333

2
3
3
4
14
2
3
2
4
2
4
2
2
3
4
2
3
2
2
3
3
3
3
2
3
9
3
3
3
3
2
5
3
5
4
4
2
2
3
9
4
3
3
2
2
4
2
5
12
4
2
2
3
2
6
2
4
2
5
2
2
2
5
2
3
4
8
3
2
5
14
11
4
2
2
2
2
5
2
2
4
3
3
2
3
2
2
6
5
4
11
4
5
5
2
2

2
2
2
2
3
2
3
2
4
2
4
2
2
3
4
2
3
2
2
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
11
2
2
2
2
2
4
2
2
2
2
2
2
2
3
2
2
2
4
2
2
2
7
6
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
4
2
3
2
2
2

[10,10]
[11,12]
[10,11]
[10,10]
[10,16]
[10,10]
[13,19]
[18,40]
[10,61]
[21,22]
[13,37]
[11,11]
[14,20]
[21,36]
[12,20]
[11,12]
[13,30]
[12,16]
[28,35]
[10,30]
[10,25]
[10,13]
[10,11]
[13,21]
[10,18]
[10,10]
[10,10]
[11,11]
[11,20]
[10,10]
[10,10]
[11,19]
[10,11]
[10,12]
[16,20]
[12,18]
[18,20]
[10,10]
[13,14]
[10,31]
[10,20]
[10,28]
[10,21]
[10,10]
[10,12]
[10,10]
[11,12]
[15,49]
[10,106]
[15,26]
[10,10]
[10,10]
[10,10]
[10,10]
[10,16]
[10,11]
[10,16]
[10,10]
[10,18]
[10,10]
[10,10]
[10,10]
[12,16]
[10,10]
[10,10]
[10,10]
[10,20]
[12,13]
[10,18]
[10,25]
[17,48]
[16,40]
[11,12]
[16,20]
[10,11]
[10,10]
[10,14]
[10,13]
[10,10]
[10,15]
[12,21]
[10,11]
[16,18]
[11,15]
[11,25]
[10,10]
[10,13]
[12,25]
[19,19]
[10,19]
[13,16]
[10,10]
[16,20]
[16,20]
[10,12]
[10,15]

TableS10

chr1:85185403
chr1:85169636
chr1:85163920
chr1:85164717
chr8:6487989
chr12:48244865
chr6:30776105
chr7:114443342
chr7:114444961
chr7:75534296
chr7:75534592
chr12:66995009
chr12:67504617
chr1:202782576
chr1:202789468
chr1:202792156
chr1:202792462
chr6:90459561
chr14:23754673
chr6:84112706
chr6:43089504
chr6:43089503
chr17:34820393
chr17:34820361
chr17:34817761
chr17:34820362
chr12:114904631
chr22:19239293
chr22:19271863
chr11:93182547
chr11:93166673
chr1:28534597
chr11:57229225
chr9:135199292
chr9:135195680
chr6:131965110
chr19:55027225
chr19:55032020
chr9:133725374
chr4:17234646
chr19:44580247
chr19:44581002
chr1:43622825
chr1:43622981
chr15:98070226
chr15:98070755
chr15:98071904
chr19:19117900
chr19:19163917
chr5:88054404
chr5:88092872
chr5:88054495
chr5:88050885
chr5:88051354
chr5:88052163
chr5:88214529
chr22:40507552
chr9:36641859
chr15:79083184
chr15:79057695
chr15:79058055
chr4:100202183
chr17:2266890
chr17:2266895
chr17:2267985
chr17:2269411
chr14:20528493
chr14:20534976
chr12:56448945
chr10:126444012
chr1:170023592
chr1:170032706
chr14:21039882
chr3:15442987
chr12:49609965
chr2:171888715
chr16:21543781
chr16:21574391
chr18:46955918
chr8:8786494
chr8:8680793
chr1:11989317
chr1:11964615
chr22:36195079
chr12:51934262
chr12:51934043
chr2:191010177
chr2:191074498
chr15:39806743
chr14:49159164
chr5:179161064
chr2:134922873
chr2:134744524
chr2:134923932
chr2:134926005
chr2:134928630

MCOLN2
MCOLN2
MCOLN2
MCOLN2
MCPH1
MCRS1
MDC1
MDFIC
MDFIC
MDH2
MDH2
MDM1
MDM2
MDM4
MDM4
MDM4
MDM4
MDN1
MDP1
ME1
MEA1
MEA1
MED1
MED1
MED1
MED1
MED13L
MED15
MED15
MED17
MED17
MED18
MED19
MED22
MED22
MED23
MED25
MED25
MED27
MED28
MED29
MED29
MED8
MED8
MEF2A
MEF2A
MEF2A
MEF2B
MEF2B
MEF2C
MEF2C
MEF2C
MEF2C
MEF2C
MEF2C
MEF2C
MEI1
MELK
MESDC1
MESDC2
MESDC2
METAP1
METT10D
METT10D
METT10D
METT10D
METT11D1
METT11D1
METTL1
METTL10
METTL13
METTL13
METTL3
METTL6
METTL7A
METTL8
METTL9
METTL9
MEX3C
MFHAS1
MFHAS1
MFN2
MFN2
MFNG
MFSD5
MFSD5
MFSD6
MFSD6
MGA
MGAT2
MGAT4B
MGAT5
MGAT5
MGAT5
MGAT5
MGAT5

coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
mixed
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
mixed
mixed
coding_exon
UTR3
UTR3
mixed
UTR5
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR5
mixed
coding_exon
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR5
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
mixed
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3

ENST00000284027:ItoV;ENST00000370608:ItoV;

ENST00000343810:KtoN;ENST00000357123:KtoN;

ENST00000303145:DtoE;ENST00000411698:DtoE;
ENST00000258149:LtoI;ENST00000311420:LtoI;ENST00000311440:LtoI;ENST00000
ENST00000367182:LtoP;ENST00000454264:LtoP;

ENST00000288087:VtoA;ENST00000396833:VtoA;
ENST00000369705:ItoV;
ENST00000244711:GtoA;
ENST00000300651:VtoA;ENST00000394287:VtoA;
ENST00000300651:GtoR;ENST00000394287:GtoR;

ENST00000281928:CtoG;

ENST00000251871:VtoE;ENST00000427225:VtoE;
ENST00000251871:ItoL;ENST00000427225:ItoL;

ENST00000368053:EtoG;ENST00000368058:EtoG;ENST00000368060:EtoG;ENST000
ENST00000312865:LtoQ;ENST00000312881:LtoQ;ENST00000377077:LtoQ;ENST000

ENST00000340208:RtoG;ENST00000424173:RtoG;ENST00000437473:RtoG;
ENST00000340208:CtoW;ENST00000437473:CtoW;

ENST00000339374:VtoA;ENST00000382985:VtoA;

ENST00000361735:VtoG;ENST00000362019:VtoG;ENST00000367737:VtoG;ENST00
ENST00000298717:StoG;
ENST00000332160:GtoE;ENST00000433599:GtoE;
ENST00000358154:TtoS;ENST00000396014:TtoS;

ENST00000235329:ItoV;ENST00000376320:ItoV;ENST00000376337:ItoV;ENST0000

ENST00000329548:LtoP;
ENST00000329548:HtoR;
ENST00000281416:YtoN;ENST00000392328:YtoN;

ENST00000292591:VtoG;ENST00000337755:VtoG;ENST00000429098:VtoG;
ENST00000281923:Cto*;ENST00000409645:Cto*;

92

+
+
+
+

+
+
+
+
+

+
+
+
+
+

+
+

+
+
+

+
+
+

+
+
+

+
+

+
+

+
+

+
+

+
+
+
+
+
+

+
+
+
+
+

AtoG
TtoA
TtoC
TtoA
AtoG
AtoC
TtoC
AtoG
TtoA
TtoA
TtoA
TtoA
CtoA
TtoC
TtoG
AtoG
TtoG
CtoT
TtoC
AtoG
GtoC
CtoG
TtoC
GtoA
TtoC
AtoC
TtoG
TtoC
TtoA
TtoA
AtoC
CtoT
AtoG
AtoT
GtoT
AtoG
TtoA
AtoG
TtoC
TtoC
TtoC
AtoG
AtoG
TtoA
AtoG
AtoG
TtoC
TtoG
CtoT
AtoG
TtoG
TtoC
TtoA
TtoA
TtoG
AtoT
AtoG
AtoG
CtoT
TtoA
TtoA
TtoA
AtoG
TtoC
TtoC
TtoG
TtoC
AtoG
TtoG
CtoT
TtoG
TtoA
AtoG
GtoA
GtoA
AtoG
AtoT
AtoG
TtoC
GtoT
TtoC
AtoG
CtoA
TtoC
TtoC
AtoG
TtoA
TtoG
TtoC
CtoA
TtoG
CtoA
AtoG
AtoG
GtoA
AtoG

0.1
0.1
0.1
0.1
0.1
0.1154
0.12
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1429
0.1304
0.2
0.3636
0.1111
0.1111
0.2
0.25
0.1
0.1111
0.1667
0.1579
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.75
0.1
0.1053
0.1
0.15
0.125
0.1429
0.1
0.1
0.1111
1
0.1
0.1
0.1
0.1
0.1111
0.125
0.1
0.1
0.1429
0.1
0.1364
0.1
0.1176
0.1429
0.1
0.1
0.1667
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1
0.1013
0.1
0.1
0.1
0.1538
0.1
0.1
0.1
0.1667
0.1
0.1
0.1
0.1
0.1
0.1579
0.1
0.1
0.1
0.1
0.1667

0.1364
0.3529
0.2727
0.1667
0.1
0.1707
0.1429
0.1
0.1429
0.1
0.1
0.1538
0.1176
0.1538
0.2
0.1333
0.2308
0.4167
0.1364
0.1111
0.6667
0.6897
0.1053
0.3333
0.1667
0.4
0.1
0.1
0.125
0.2
0.1818
0.125
0.1
0.1
0.8
0.1
0.1818
0.1364
0.2
0.1538
0.1667
0.2
0.1538
0.1875
1
0.125
0.1
0.1667
0.1
0.25
0.1613
0.1
0.2
0.1429
0.1111
0.1429
0.1429
0.2308
0.1818
0.1
0.1429
0.1818
0.1818
0.1818
0.1111
0.1
0.1111
0.2727
0.1
0.1538
0.1
0.1
0.1538
0.2
0.1053
0.1111
0.129
0.1667
0.1
0.1
0.1818
0.125
0.25
0.1667
0.2
0.1
0.1333
0.1
0.1333
0.125
0.2
0.1
0.1176
0.125
0.1667
0.1875

4
7
10
5
2
5
9
2
8
2
3
3
2
7
3
4
2
2
2
3
11
12
5
4
3
4
3
3
3
7
3
2
2
2
2
2
3
4
6
8
4
3
5
2
5
3
3
2
2
8
3
4
3
3
4
5
6
2
4
2
2
8
5
4
5
7
2
6
3
4
2
4
3
3
2
2
8
4
5
2
4
3
4
5
4
2
2
2
2
2
2
2
2
2
3
3

2
4
5
2
2
2
3
2
4
2
2
2
2
2
2
2
2
2
2
2
11
11
2
4
2
4
2
2
2
3
3
2
2
2
2
2
2
2
3
3
2
2
3
2
5
2
2
2
2
2
3
2
3
2
2
2
3
2
3
2
2
2
2
2
2
2
2
3
2
2
2
3
2
2
2
2
4
2
3
2
3
2
3
5
2
2
2
2
2
2
2
2
2
2
2
2

[10,22]
[10,17]
[10,11]
[12,20]
[10,10]
[27,41]
[14,25]
[10,10]
[10,27]
[10,10]
[10,10]
[10,13]
[17,17]
[10,13]
[10,14]
[15,23]
[10,13]
[11,12]
[18,22]
[10,18]
[17,33]
[16,37]
[10,19]
[12,32]
[12,12]
[10,27]
[10,10]
[20,20]
[10,16]
[10,18]
[10,11]
[16,18]
[10,10]
[10,10]
[10,12]
[10,10]
[11,19]
[10,22]
[10,20]
[13,24]
[12,21]
[10,10]
[10,16]
[16,18]
[10,18]
[10,16]
[10,10]
[10,12]
[10,10]
[16,28]
[32,50]
[10,21]
[10,11]
[14,14]
[10,10]
[22,28]
[10,48]
[13,17]
[11,14]
[10,10]
[10,14]
[11,12]
[10,11]
[11,15]
[18,20]
[10,10]
[11,18]
[10,19]
[10,10]
[10,13]
[10,10]
[10,10]
[13,18]
[10,10]
[10,19]
[10,18]
[31,79]
[10,18]
[10,10]
[10,10]
[11,18]
[16,20]
[10,12]
[10,34]
[10,12]
[10,10]
[10,15]
[10,10]
[10,15]
[10,16]
[10,19]
[10,10]
[10,17]
[10,16]
[10,12]
[12,16]

TableS10

chr10:103547721
chr10:103557497
chr10:103534216
chr10:103535191
chr10:103535508
chr3:128892800
chr10:131455357
chr16:4679749
chr6:109880145
chr19:1202895
chr19:1209544
chr19:1210079
chr19:285517
chr3:99151548
chr3:99168970
chr17:4730648
chr17:4734678
chr17:4735528
chr17:4738060
chr17:4741970
chr10:89301991
chr7:7601178
chr7:7601257
chr17:5333339
chr17:5333499
chr2:99156910
chr10:129795004
chr10:129784964
chr10:129786112
chr2:122201778
chr22:39136798
chr7:130798583
chr7:130773150
chr7:130773159
chr7:130828387
chr1:46818793
chr1:46818845
chr19:1988850
chr19:1988854
chr19:1989459
chr19:1990434
chr19:1988517
chr19:1988518
chr19:1988647
chr3:12599065
chr3:12599780
chr3:12600093
chr3:12600094
chr3:12600096
chr17:53638853
chr17:53648448
chr12:119619228
chr12:119620354
chr12:119623907
chr12:119624010
chr4:185868322
chr4:185883128
chr4:185853185
chr4:185853243
chr4:185853330
chr3:37067304
chr11:117881701
chr11:117854006
chr11:117896765
chr11:117899351
chr11:117899760
chr12:47699298
chr12:47699323
chr12:47699888
chr12:47700029
chr12:47701036
chr12:47701060
chr7:151476867
chr7:151490723
chr7:151695192
chr19:6221745
chr10:22002343
chr10:22071629
chr6:168091947
chr17:34126673
chr17:34137993
chr17:37977893
chr17:37977894
chr17:37978446
chr17:37978555
chr4:146786692
chr1:45749309
chr1:45749310
chr17:50854049
chr17:50825745
chr11:101899196
chr10:99208103
chr14:60344826
chr19:2022040
chr19:2022045
chr1:46846719

MGEA5
MGEA5
MGEA5
MGEA5
MGEA5
MGLL
MGMT
MGRN1
MICAL1
MIDN
MIDN
MIDN
MIER2
MINA
MINA
MINK1
MINK1
MINK1
MINK1
MINK1
MINPP1
MIOS
MIOS
MIS12
MIS12
MITD1
MKI67
MKI67
MKI67
MKI67IP
MKL1
MKLN1
MKLN1
MKLN1
MKLN1
MKNK1
MKNK1
MKNK2
MKNK2
MKNK2
MKNK2
MKNK2
MKNK2
MKNK2
MKRN2
MKRN2
MKRN2
MKRN2
MKRN2
MKS1
MKS1
MLEC
MLEC
MLEC
MLEC
MLF1IP
MLF1IP
MLF1IP
MLF1IP
MLF1IP
MLH1
MLL
MLL
MLL
MLL
MLL
MLL2
MLL2
MLL2
MLL2
MLL2
MLL2
MLL3
MLL3
MLL3
MLLT1
MLLT10
MLLT10
MLLT4
MLLT6
MLLT6
MLX
MLX
MLX
MLX
MMAA
MMACHC
MMACHC
MMD
MMD
MMP7
MMS19
MNAT1
MOBKL2A
MOBKL2A
MOBKL2C

coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
coding_exon
coding_exon
mixed
mixed
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
mixed
mixed
UTR3
coding_exon
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3

ENST00000370094:CtoR;
ENST00000357797:TtoN;ENST00000361464:TtoN;ENST00000370094:TtoN;ENST00

ENST00000358577:TtoP;ENST00000358807:TtoP;
ENST00000300952:TtoP;ENST00000395622:TtoP;

ENST00000264819:HtoQ;
ENST00000333396:QtoL;ENST00000394198:QtoL;ENST00000442492:QtoL;
ENST00000330299:TtoI;ENST00000333396:TtoI;ENST00000360258:TtoI;ENST00000

ENST00000340080:WtoR;ENST00000405785:WtoR;
ENST00000340080:KtoM;ENST00000405785:KtoM;

ENST00000368653:LtoQ;ENST00000368654:LtoQ;

ENST00000285814:NtoD;

ENST00000341183:VtoA;ENST00000342571:StoP;ENST00000371944:StoP;ENST000

ENST00000393119:FtoI;
ENST00000337050:EtoD;ENST00000393119:EtoD;ENST00000393120:EtoD;

ENST00000281453:StoY;

ENST00000354520:StoN;ENST00000359313:StoN;
ENST00000354520:RtoP;ENST00000359313:RtoP;
ENST00000354520:FtoS;ENST00000359313:FtoS;

ENST00000262189:WtoR;ENST00000355193:WtoR;

ENST00000252674:LtoP;

ENST00000325718:StoP;

ENST00000281317:TtoP;

ENST00000262065:FtoL;
ENST00000260227:ItoV;
ENST00000261245:DtoG;

93

+
+

+
+
+

+
+
+
+
+
+
+
+
+
+

+
+
+
+

+
+
+
+
+

+
+
+
+

+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+

TtoC
CtoA
AtoG
TtoC
CtoA
TtoC
AtoG
TtoC
AtoC
AtoC
GtoC
GtoA
TtoG
AtoT
CtoT
TtoG
TtoC
GtoC
AtoC
TtoC
AtoC
TtoC
AtoT
CtoA
AtoC
TtoC
TtoA
TtoA
AtoG
AtoG
AtoG
TtoC
TtoC
TtoC
AtoG
TtoC
TtoA
GtoT
GtoT
CtoT
CtoT
AtoG
AtoG
CtoA
TtoA
AtoG
CtoA
CtoG
GtoA
TtoA
GtoT
AtoG
CtoG
AtoG
AtoG
CtoA
TtoC
TtoC
TtoA
TtoA
TtoA
GtoA
GtoC
TtoC
TtoG
GtoC
TtoC
TtoC
GtoA
AtoG
TtoG
TtoA
TtoC
TtoC
CtoT
TtoC
TtoC
TtoC
AtoG
TtoC
AtoG
AtoC
GtoT
AtoT
AtoC
AtoC
GtoT
TtoC
TtoC
AtoG
AtoG
TtoG
AtoG
TtoC
AtoG
AtoG

0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1351
0.1053
0.1
0.1
0.1
0.1
0.1538
0.125
0.1
0.1
0.125
0.6667
0.1
0.1
0.1
0.1
0.1
0.1765
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1011
0.1
0.4542
0.1022
0.1023
0.1
0.1031
0.1053
0.1176
0.1
0.1
0.1
0.1
0.1
0.1034
0.1
0.1532
0.1333
0.1
0.1
0.1818
0.1
0.1176
0.1
0.1
0.1
0.1
0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1667
0.1
0.1053
0.1
0.1
0.6364
0.1463
0.1
0.1
0.1
0.1
0.1
0.1111
0.1818
0.1

0.2
0.1667
0.2308
0.1053
0.1333
0.129
0.1
0.1429
0.3
0.12
0.1429
0.2
0.1
0.1
0.1818
0.1818
0.1
0.1
0.1852
1
0.1
0.1
0.1667
0.1
0.1538
0.2222
0.1667
0.1
0.1
0.2
0.1739
0.1
0.1
0.1111
0.1818
0.1538
0.1
0.139
0.1235
0.484
0.1469
0.125
0.1447
0.1525
0.125
0.1538
0.2143
0.2143
0.1053
0.1111
0.1
0.1333
0.1579
0.2199
0.1429
0.1
0.1111
0.2
0.1
0.2
0.1
0.1
0.1111
0.1111
0.1818
0.1
0.2
0.1304
0.125
0.1176
0.1
0.1
0.1
0.1
1
0.1176
0.1
0.2
0.1111
0.1
0.1429
0.1667
0.1333
0.1053
0.1333
0.1
0.9167
0.2619
0.1
0.1818
0.1071
0.1818
0.1
0.3125
0.1818
0.1

3
2
6
2
2
5
3
3
7
4
5
3
2
5
5
2
2
5
8
3
3
3
2
4
3
2
4
3
3
3
9
2
2
2
2
4
4
6
3
2
8
13
11
9
5
3
3
2
2
2
2
8
2
7
2
2
3
4
3
5
2
2
2
5
6
2
5
2
2
4
2
2
4
5
4
5
3
2
2
2
11
2
3
4
4
2
3
16
6
2
3
2
2
17
9
3

2
2
3
2
2
2
2
2
3
2
3
3
2
2
2
2
2
2
4
3
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
4
2
2
2
3
3
5
2
2
3
2
2
2
2
2
2
4
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
3
2
2
2
2
4
2
2
2
2
2
4
2
3
2
2
2
3
13
2
2
2
2
2
13
2
2

[10,10]
[10,12]
[10,16]
[20,20]
[10,15]
[18,31]
[10,10]
[10,14]
[10,37]
[19,25]
[10,25]
[10,15]
[10,10]
[10,10]
[11,13]
[16,22]
[10,10]
[10,10]
[15,33]
[15,45]
[10,10]
[10,20]
[10,12]
[10,10]
[10,13]
[10,17]
[10,12]
[10,10]
[10,20]
[10,20]
[10,23]
[10,10]
[10,10]
[10,10]
[10,11]
[10,13]
[10,10]
[72,376]
[81,354]
[252,584]
[138,211]
[24,88]
[43,78]
[43,230]
[19,24]
[13,18]
[10,25]
[10,14]
[10,19]
[10,18]
[10,10]
[15,29]
[19,20]
[112,141]
[14,15]
[10,10]
[10,36]
[10,11]
[10,10]
[11,17]
[10,10]
[10,10]
[10,10]
[10,18]
[11,13]
[10,10]
[10,10]
[20,23]
[10,17]
[10,17]
[10,10]
[10,10]
[10,10]
[10,10]
[15,19]
[10,17]
[10,10]
[10,10]
[10,18]
[10,10]
[14,27]
[12,12]
[10,17]
[19,19]
[10,15]
[10,10]
[10,12]
[29,113]
[10,10]
[10,11]
[10,28]
[10,11]
[10,10]
[11,54]
[22,34]
[10,10]

TableS10

chr1:46847009
chr16:75785733
chr22:29665975
chr15:76973554
chr15:76974239
chr15:76976499
chr15:76976633
chr15:76977068
chr1:2325023
chr17:7431312
chr17:7432209
chr16:69448
chr13:19122165
chr15:72977623
chr17:16987693
chr17:17009022
chr17:17009651
chr17:17010265
chr17:17029006
chr22:35755213
chr2:27385870
chr1:179291216
chr1:179291782
chr21:32608768
chr4:6693439
chr4:6760486
chr4:6760588
chr19:13737940
chr19:13737941
chr19:13740429
chr17:32032637
chr17:32039453
chr13:20649638
chr13:20649640
chr11:65959891
chr17:77284947
chr17:77280832
chr6:44189432
chr11:59330268
chr6:160139295
chr1:154973754
chr16:357701
chr16:357704
chr16:357402
chr2:99180331
chr19:17277709
chr2:86293020
chr21:25879898
chr12:92405412
chr17:33732574
chr17:33732579
chr11:73193758
chr11:73253284
chr9:103192514
chr12:6471588
chr12:6471592
chr14:22373397
chr2:74552630
chr1:226361013
chr1:226361016
chr1:173259131
chr1:36693980
chr1:36693985
chr10:74679260
chr10:74679415
chr10:74680504
chr6:43754319
chr6:30702142
chr7:43872706
chr3:15059458
chr3:15068718
chr3:15068732
chr3:15066245
chr5:71645702
chr8:81104836
chr8:81104827
chr8:81104828
chr8:81104835
chr13:40201610
chr5:68567023
chr2:95139445
chr6:24523344
chr6:24531199
chr6:24532044
chr1:19458969
chr11:59994108
chr11:59986231
chr8:72916763
chr2:47490745
chr2:47547371
chr2:47555824
chr2:47563832
chr5:80207417
chr6:31834932
chr6:31835952
chr2:47879256

MOBKL2C
MON1B
MORC2
MORF4L1
MORF4L1
MORF4L1
MORF4L1
MORF4L1
MORN1
MPDU1
MPDU1
MPG
MPHOSPH8
MPI
MPRIP
MPRIP
MPRIP
MPRIP
MPRIP
MPST
MPV17
MR1
MR1
MRAP
MRFAP1
MRFAP1L1
MRFAP1L1
MRI1
MRI1
MRI1
MRM1
MRM1
MRP63
MRP63
MRPL11
MRPL12
MRPL12
MRPL14
MRPL16
MRPL18
MRPL24
MRPL28
MRPL28
MRPL28
MRPL30
MRPL34
MRPL35
MRPL39
MRPL42
MRPL45
MRPL45
MRPL48
MRPL48
MRPL50
MRPL51
MRPL51
MRPL52
MRPL53
MRPL55
MRPL55
MRPS14
MRPS15
MRPS15
MRPS16
MRPS16
MRPS16
MRPS18A
MRPS18B
MRPS24
MRPS25
MRPS25
MRPS25
MRPS25
MRPS27
MRPS28
MRPS28
MRPS28
MRPS28
MRPS31
MRPS36
MRPS5
MRS2
MRS2
MRS2
MRTO4
MS4A1
MS4A1
MSC
MSH2
MSH2
MSH2
MSH2
MSH3
MSH5
MSH5
MSH6

UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
mixed
coding_exon
mixed
coding_exon
mixed
UTR3
mixed
mixed
mixed
mixed
UTR3
mixed
UTR3
UTR3
UTR3
coding_exon
UTR5
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
mixed
mixed
UTR3
UTR3
UTR5
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
mixed
mixed
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
coding_exon
UTR3
UTR3
mixed
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
mixed
mixed
UTR3
UTR3
UTR3
UTR5
UTR3
mixed
mixed
mixed
mixed
coding_exon
mixed
mixed
coding_exon

ENST00000248248:EtoG;ENST00000439557:EtoG;
ENST00000215862:LtoV;ENST00000397641:LtoV;

ENST00000250124:QtoR;ENST00000396501:RtoG;ENST00000449455:RtoG;
ENST00000219431:QtoK;ENST00000356432:QtoK;ENST00000397817:QtoK;ENST00

ENST00000339944:VtoA;ENST00000399786:VtoA;

ENST00000040663:LtoV;ENST00000445479:LtoV;
ENST00000040663:LtoP;ENST00000445479:LtoP;
ENST00000040663:EtoG;ENST00000319545:EtoG;ENST00000445479:EtoG;

ENST00000199706:VtoG;ENST00000389675:VtoG;ENST00000397734:VtoG;ENST00
ENST00000199706:VtoG;ENST00000389675:VtoG;ENST00000397734:VtoG;ENST00

ENST00000252602:VtoG;

ENST00000476371:FtoV;
ENST00000373116:QtoR;
ENST00000373116:DtoE;

ENST00000372116:TtoA;ENST00000372118:TtoA;ENST00000372133:TtoA;

ENST00000261413:HtoR;ENST00000457646:HtoR;
ENST00000276585:PtoL;
ENST00000276585:KtoR;
ENST00000276585:KtoQ;

ENST00000272418:KtoE;

ENST00000265081:QtoE;

94

+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+

+
+
+
+

+
+
+
+
+
+
+

+
+

+
+
+

+
+
+
+
+

+
+
+
+
+
+

+
+
+
+
+
+
+
+

AtoG
AtoG
CtoG
TtoC
TtoC
TtoA
TtoC
AtoG
CtoT
AtoG
TtoC
CtoA
AtoC
GtoA
GtoA
TtoC
AtoC
TtoC
TtoG
TtoC
TtoC
TtoC
TtoC
TtoC
TtoG
TtoC
CtoA
CtoG
TtoC
AtoG
GtoA
GtoT
CtoA
AtoG
TtoG
AtoG
TtoA
TtoC
TtoA
TtoC
CtoT
TtoG
TtoG
CtoG
CtoA
TtoG
AtoG
TtoG
TtoC
TtoC
AtoG
CtoG
TtoC
TtoG
GtoA
TtoC
CtoA
CtoG
TtoC
AtoG
TtoG
AtoG
CtoG
TtoA
TtoG
GtoA
AtoG
TtoC
TtoA
GtoT
GtoA
GtoA
TtoC
AtoG
CtoT
AtoG
AtoC
CtoT
AtoG
TtoC
AtoG
GtoC
TtoG
CtoT
TtoA
CtoA
CtoA
TtoA
TtoC
TtoC
AtoG
TtoA
CtoG
TtoA
AtoG
AtoG

0.1
0.1
0.1
0.1031
0.1098
0.1228
0.1538
0.1111
0.1
0.1333
0.1053
0.9855
0.1
0.1111
0.1
0.1
0.1
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.1667
0.1053
0.1333
0.1053
0.1176
0.15
0.1
0.1333
0.1
0.125
0.1111
0.1429
0.1333
0.1389
0.1
0.1111
0.2821
0.102
0.1538
0.125
0.1
0.16
0.1111
0.1
0.1
0.1
0.2222
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1538
0.1053
0.1034
0.1
0.1
0.1064
0.1
0.1
0.1
0.1053
0.1
0.1
0.125
0.1111
0.2667
0.129
0.1
0.1111
0.1176
0.1053
0.1429
0.1
0.1
0.1
0.7273
0.4481
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1154

0.1
0.1429
0.1818
0.1918
0.2
0.1875
0.1852
0.2
0.2
0.1429
0.1538
1
0.1333
0.1667
0.1176
0.1
0.1667
0.1
0.1667
0.1538
0.1429
0.1
0.1
0.1818
0.2
0.1136
0.2
0.2308
0.3333
0.2
0.2308
0.16
0.1
0.2
0.1818
0.1765
0.3
0.1579
0.1176
0.1143
0.2927
0.2157
0.2308
0.1333
0.1111
0.2143
0.125
0.1667
0.3
0.1429
0.3
0.1
0.1818
0.15
0.1
0.3333
0.1538
0.125
0.1818
0.1
0.1429
0.2143
0.2353
0.1304
0.1429
0.1875
0.1818
0.3333
0.1
0.1
0.2
0.1429
0.1667
0.1
0.1818
0.2857
0.2857
0.2308
0.125
0.1481
0.1364
0.1667
0.5
0.1
0.2308
0.2273
1
0.4615
0.1
0.1176
0.25
0.2
0.1
0.2308
0.2
0.1333

2
4
4
3
3
11
4
3
3
5
5
19
2
7
3
4
2
2
4
3
4
2
2
3
6
4
3
3
3
4
3
2
2
2
4
2
2
4
4
6
2
3
4
2
3
5
5
3
9
2
3
2
2
12
2
14
3
6
6
3
2
7
5
3
8
8
2
11
2
2
7
8
2
6
4
7
4
4
4
3
3
4
3
2
3
8
2
2
4
5
5
6
3
3
4
5

2
2
2
2
2
3
2
2
3
2
2
19
2
3
2
2
2
2
2
2
2
2
2
3
2
2
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
6
2
2
2
2
4
2
11
3
2
3
2
2
6
2
2
4
3
2
7
2
2
4
3
2
2
2
3
2
3
2
2
2
2
2
2
3
5
2
2
2
2
2
2
2
2
2
2

[10,10]
[14,20]
[10,11]
[73,98]
[45,82]
[49,150]
[13,27]
[10,18]
[10,14]
[30,35]
[13,19]
[12,101]
[10,15]
[10,15]
[17,20]
[10,10]
[10,12]
[10,10]
[12,15]
[10,13]
[10,14]
[10,10]
[10,10]
[10,11]
[10,18]
[20,45]
[10,15]
[13,19]
[12,17]
[10,20]
[10,13]
[15,25]
[10,10]
[10,16]
[10,11]
[14,17]
[10,15]
[20,36]
[10,18]
[19,70]
[39,41]
[49,51]
[26,53]
[15,16]
[10,11]
[14,25]
[16,18]
[10,12]
[10,55]
[10,14]
[10,10]
[10,10]
[10,11]
[10,20]
[10,10]
[10,62]
[10,18]
[10,24]
[10,13]
[10,20]
[10,14]
[10,23]
[13,17]
[19,23]
[14,38]
[10,32]
[10,11]
[10,47]
[10,10]
[10,10]
[10,19]
[14,19]
[10,12]
[10,10]
[11,16]
[14,27]
[14,15]
[13,31]
[10,16]
[27,27]
[17,22]
[12,19]
[12,21]
[10,10]
[10,13]
[10,27]
[10,11]
[52,242]
[10,10]
[10,17]
[10,16]
[10,10]
[10,10]
[10,13]
[10,21]
[15,27]

TableS10

chr17:52833739
chr17:35541317
chr17:35539033
chr17:35545056
chr3:137353522
chr16:55200849
chr14:105007919
chr11:62117313
chr11:62117518
chr2:42659827
chr6:37045370
chr11:47607128
chr8:98806531
chr8:98807707
chr8:98807712
chr8:98809278
chr2:241685401
chr2:241676558
chr1:93317547
chr10:135064898
chr10:135083969
chr15:77978398
chr13:26912392
chr13:26912412
chr15:29022080
chr15:29018863
chr11:95207026
chr11:95207937
chr22:29011282
chr22:29059127
chr22:29060039
chr22:29068221
chr22:29153204
chr22:29652830
chr22:29696785
chr22:29699574
chr22:29701776
chr22:28751950
chr22:28753586
chr17:53939667
chr6:74258783
chr1:11099657
chr1:11090143
chr1:235092241
chr13:40706086
chr2:176896369
chr2:176910654
chr14:56816774
chr14:56811318
chr14:56825908
chr1:20699402
chr19:1315544
chr1:45569455
chr16:29766838
chr21:41733614
chr21:41729735
chr21:41753006
chr21:41753007
chr21:41753008
chr21:41753009
chr21:41753010
chr21:41725842
chr21:41725843
chr21:41702707
chr10:112035621
chr6:135557262
chr6:135581803
chr13:76523234
chr13:76641793
chr13:76597486
chr13:76662412
chr13:76569795
chr13:76517037
chr13:76517328
chr15:46228847
chr15:46246888
chr15:46221699
chr17:8357846
chr17:8337792
chr17:8318433
chr16:15725832
chr16:15726520
chr22:35028580
chr22:35007282
chr18:3243982
chr18:3245809
chr18:3244005
chr18:3246194
chr18:3237812
chr18:3237816
chr18:3267820
chr18:3267847
chr18:3267897
chr18:3267804
chr18:3262970
chr18:3267347

MSI2
MSL1
MSL1
MSL1
MSL2
MT2A
MTA1
MTA2
MTA2
MTA3
MTCH1
MTCH2
MTDH
MTDH
MTDH
MTDH
MTERFD2
MTERFD2
MTF2
MTG1
MTG1
MTHFS
MTIF3
MTIF3
MTMR10
MTMR10
MTMR2
MTMR2
MTMR3
MTMR3
MTMR3
MTMR3
MTMR3
MTMR3
MTMR3
MTMR3
MTMR3
MTMR3
MTMR3
MTMR4
MTO1
MTOR
MTOR
MTR
MTRF1
MTX2
MTX2
MUDENG
MUDENG
MUDENG
MUL1
MUM1
MUTYH
MVP
MX1
MX1
MX1
MX1
MX1
MX1
MX1
MX1
MX1
MX2
MXI1
MYB
MYB
MYCBP2
MYCBP2
MYCBP2
MYCBP2
MYCBP2
MYCBP2
MYCBP2
MYEF2
MYEF2
MYEF2
MYH10
MYH10
MYH10
MYH11
MYH11
MYH9
MYH9
MYL12A
MYL12A
MYL12A
MYL12A
MYL12A
MYL12A
MYL12B
MYL12B
MYL12B
MYL12B
MYL12B
MYL12B

coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
UTR5
coding_exon
UTR3
mixed
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR5
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
mixed
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR5
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon

ENST00000284073:MtoV;ENST00000322684:MtoV;ENST00000416426:MtoV;ENST0
ENST00000339569:RtoS;ENST00000398532:RtoS;

ENST00000405094:LtoP;ENST00000405592:LtoP;ENST00000406652:LtoP;ENST0000
ENST00000302503:CtoG;

ENST00000391980:VtoA;ENST00000406593:VtoA;ENST00000407095:VtoA;

ENST00000381116:GtoE;ENST00000381120:GtoE;ENST00000405591:GtoE;ENST000

ENST00000323456:NtoK;
ENST00000357845:RtoS;ENST00000370300:RtoS;ENST00000370305:RtoS;ENST000
ENST00000361445:LtoP;ENST00000376838:LtoP;
ENST00000361445:CtoG;ENST00000376838:CtoG;
ENST00000366577:VtoA;ENST00000417743:VtoA;
ENST00000379477:AtoS;ENST00000379480:AtoS;ENST00000430347:AtoS;
ENST00000249442:FtoV;ENST00000392529:FtoV;
ENST00000261558:StoP;ENST00000431972:StoP;

ENST00000311401:HtoR;ENST00000344663:HtoR;ENST00000415183:HtoR;
ENST00000354383:TtoP;ENST00000355498:TtoP;ENST00000372098:TtoP;ENST000
ENST00000288383:VtoG;ENST00000398598:VtoG;ENST00000398600:VtoG;ENST00

ENST00000237302:NtoD;ENST00000316528:NtoD;ENST00000341911:NtoD;ENST00
ENST00000357337:VtoG;ENST00000407578:VtoG;
ENST00000357337:LtoR;ENST00000407578:LtoR;
ENST00000357337:LtoP;ENST00000407578:LtoP;
ENST00000357337:GtoD;ENST00000407578:GtoD;

ENST00000269243:WtoG;ENST00000360416:WtoG;ENST00000379980:WtoG;ENST
ENST00000269243:LtoP;ENST00000360416:LtoP;ENST00000379980:LtoP;ENST0000

ENST00000216181:WtoG;ENST00000337818:WtoG;ENST00000438303:WtoG;
ENST00000217652:LtoI;
ENST00000217652:EtoK;

ENST00000237500:TtoR;ENST00000400174:TtoR;ENST00000400175:TtoR;ENST000
ENST00000237500:RtoT;ENST00000400174:RtoT;ENST00000400175:RtoT;ENST000
ENST00000237500:RtoS;ENST00000400174:RtoS;ENST00000400175:RtoS;ENST000
ENST00000237500:MtoV;ENST00000400174:MtoV;ENST00000400175:MtoV;ENST0
ENST00000237500:MtoT;ENST00000400174:MtoT;ENST00000400175:MtoT;ENST0
ENST00000237500:Lto*;ENST00000400174:Lto*;ENST00000400175:Lto*;ENST0000

95

+
+
+
+

+
+

+
+
+
+

+
+
+

+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+

AtoG
GtoT
AtoG
TtoC
TtoA
CtoA
TtoC
TtoC
TtoA
TtoC
TtoC
TtoG
AtoC
TtoC
AtoG
TtoC
TtoC
GtoA
AtoG
TtoA
TtoA
CtoT
GtoA
TtoG
GtoA
AtoG
TtoG
TtoC
TtoC
AtoG
AtoT
AtoC
TtoG
AtoG
TtoC
GtoC
TtoA
TtoC
GtoA
TtoG
AtoC
TtoC
TtoG
TtoC
GtoT
TtoG
TtoC
TtoC
TtoG
AtoG
TtoC
AtoG
AtoC
TtoC
TtoG
CtoA
CtoA
AtoG
GtoA
AtoG
CtoA
TtoC
TtoC
AtoG
AtoG
AtoG
AtoG
TtoG
TtoG
TtoC
GtoA
TtoG
CtoA
TtoA
TtoC
GtoT
TtoA
TtoG
TtoC
TtoG
TtoC
GtoT
TtoG
AtoT
TtoA
GtoA
TtoC
TtoC
AtoG
GtoT
CtoG
GtoC
CtoA
AtoG
TtoC
TtoG

0.125
0.1
0.1
0.1053
0.1
0.1176
0.1034
0.1111
0.1
0.1
0.1
0.102
0.1667
0.1
0.1
0.1176
0.1333
0.1
0.125
0.1
0.1111
0.2308
0.1
0.125
0.125
0.1
0.1
0.1
0.1
0.1
0.125
0.1111
0.1207
0.1
0.1
0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1667
0.1009
0.1111
0.1
0.1176
0.1111
0.1089
0.6667
0.1818
0.1
0.1
0.1429
0.1
0.1
0.1111
0.1
0.1
0.1
0.15
0.1
0.1538
0.1429
0.1
0.1
0.1
0.1
0.1111
0.1
0.1111
0.1053
0.1
0.1
0.1
0.2727
0.1
0.1333
0.1111
0.1
0.3636
0.1
0.1061
0.1818
0.1

0.2857
0.1818
0.1026
0.2
0.1
0.2143
0.1111
0.2083
0.1053
0.1538
0.1538
0.1304
0.1667
0.1
0.1667
0.3
0.2143
0.1
0.1538
0.25
0.1579
0.6429
0.1333
0.1429
0.1538
0.1
0.1818
0.1
0.1
0.1
0.1538
0.125
0.2571
0.1176
0.1667
0.3
0.1538
0.1
0.1
0.1
0.3
0.1111
0.1176
0.1
0.1429
0.2
0.1818
0.1429
0.125
0.1
0.1
0.1176
0.1765
0.2917
0.2
0.125
0.2286
0.2703
0.2105
0.1429
1
0.1818
0.1538
0.1429
0.1667
0.1
0.1111
0.1579
0.1034
0.1538
0.1
0.1538
0.25
0.1538
0.2
0.1
0.2222
0.1111
0.1111
0.2
0.1
0.1765
0.2083
0.1
0.1538
0.1818
0.6364
0.1176
0.1667
0.1176
0.1538
0.5385
0.5
0.1803
0.1923
0.1818

4
7
3
2
2
6
8
14
3
8
2
11
7
2
2
5
4
2
3
2
4
3
3
4
5
2
4
2
2
2
11
4
5
2
3
6
3
2
3
3
3
3
4
2
3
4
4
3
4
2
2
6
7
6
15
4
7
5
10
5
9
6
8
2
4
3
5
4
5
5
4
9
3
9
5
2
2
2
4
2
4
4
3
3
6
2
7
6
2
3
2
3
3
8
3
4

2
3
2
2
2
2
3
8
2
2
2
5
2
2
2
4
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
4
4
9
3
2
2
5
2
9
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
3
2
2
7
4
2
2
2
3
2
3
2
2

[21,24]
[11,20]
[10,39]
[10,20]
[10,10]
[14,17]
[18,37]
[10,34]
[10,19]
[10,13]
[10,13]
[63,98]
[12,18]
[10,20]
[12,30]
[10,17]
[14,15]
[10,10]
[13,16]
[10,16]
[10,21]
[13,16]
[10,15]
[14,16]
[13,16]
[10,10]
[11,11]
[10,10]
[10,10]
[10,10]
[13,16]
[81,162]
[58,106]
[10,17]
[10,12]
[10,17]
[10,13]
[10,10]
[10,20]
[10,10]
[10,10]
[10,18]
[17,18]
[10,10]
[10,14]
[10,10]
[11,13]
[10,14]
[10,16]
[10,10]
[10,10]
[10,17]
[10,22]
[13,26]
[34,308]
[10,19]
[10,37]
[17,37]
[15,24]
[14,112]
[10,36]
[11,11]
[10,13]
[10,14]
[12,14]
[10,20]
[10,18]
[19,36]
[11,29]
[10,13]
[10,10]
[13,21]
[10,12]
[13,13]
[10,14]
[10,10]
[10,10]
[10,10]
[10,18]
[10,10]
[10,20]
[10,17]
[19,56]
[10,20]
[11,13]
[10,11]
[10,26]
[10,20]
[12,16]
[17,18]
[10,13]
[10,13]
[10,24]
[61,124]
[11,26]
[10,11]

TableS10

chr18:3267900
chr18:3267822
chr18:3267384
chr18:3267785
chr18:3267821
chr18:3267869
chr18:3267890
chr18:3268180
chr18:3268181
chr18:3268182
chr4:662807
chr4:662501
chr12:54841622
chr12:54841624
chr12:54841625
chr12:54841626
chr12:54841628
chr6:16253324
chr6:16253163
chr6:16255349
chr3:170979928
chr17:24466496
chr17:31941403
chr17:31941404
chr17:31925818
chr17:1328486
chr17:27846046
chr15:57215859
chr15:57215864
chr15:57452175
chr15:50400922
chr15:50455992
chr15:50400955
chr15:50407418
chr15:50400936
chr15:50400975
chr6:76653370
chr6:76681515
chr6:76682191
chr6:76583956
chr15:69906127
chr15:69906135
chr15:69903381
chr19:17174651
chr16:31046114
chr17:45250250
chr8:41907054
chr10:76460236
chr13:32010783
chr3:176471540
chr12:55394735
chr12:55394717
chr12:55404520
chr12:55404518
chr12:55404517
chr12:55392946
chr12:55394726
chr12:55394727
chr12:55392932
chr12:55392945
chr12:55394731
chr12:55405013
chr4:166084397
chr4:166084400
chr4:166084407
chr4:166084410
chr1:1673692
chr1:1674121
chr11:70870648
chr11:70867162
chr11:70890221
chr16:65414678
chr22:40784506
chr22:40784610
chr22:40784799
chr17:37942949
chr17:37949481
chr17:37949470
chr17:37949472
chr17:37949759
chr9:99879083
chr11:2953860
chr11:2956122
chr11:2936276
chr11:2950006
chr11:2942533
chr11:2936285
chr11:2957017
chr11:2942510
chr19:55531609
chr19:55531647
chr19:55531648
chr19:55532095
chr17:78039231
chr4:140498137
chr4:140529240

MYL12B
MYL12B
MYL12B
MYL12B
MYL12B
MYL12B
MYL12B
MYL12B
MYL12B
MYL12B
MYL5
MYL5
MYL6
MYL6
MYL6
MYL6
MYL6
MYLIP
MYLIP
MYLIP
MYNN
MYO18A
MYO19
MYO19
MYO19
MYO1C
MYO1D
MYO1E
MYO1E
MYO1E
MYO5A
MYO5A
MYO5A
MYO5A
MYO5A
MYO5A
MYO6
MYO6
MYO6
MYO6
MYO9A
MYO9A
MYO9A
MYO9B
MYST1
MYST2
MYST3
MYST4
N4BP2L2
NAALADL2
NACA
NACA
NACA
NACA
NACA
NACA
NACA
NACA
NACA
NACA
NACA
NACA
NACA3P
NACA3P
NACA3P
NACA3P
NADK
NADK
NADSYN1
NADSYN1
NADSYN1
NAE1
NAGA
NAGA
NAGA
NAGLU
NAGLU
NAGLU
NAGLU
NAGLU
NANS
NAP1L4
NAP1L4
NAP1L4
NAP1L4
NAP1L4
NAP1L4
NAP1L4
NAP1L4
NAPSB
NAPSB
NAPSB
NAPSB
NARF
NARG1
NARG1

coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR5
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
coding_exon
coding_exon
UTR3

ENST00000237500:ItoV;ENST00000400174:ItoV;ENST00000400175:ItoV;ENST0000
ENST00000237500:DtoY;ENST00000400174:DtoY;ENST00000400175:DtoY;ENST000

ENST00000400159:TtoA;
ENST00000400159:StoP;

ENST00000349606:StoP;ENST00000356840:StoP;
ENST00000349606:HtoR;ENST00000356840:HtoR;
ENST00000349841:StoR;ENST00000356716:StoR;ENST00000392733:StoR;
ENST00000354329:RtoW;ENST00000354682:RtoW;ENST00000359450:RtoW;ENST0
ENST00000268852:LtoR;ENST00000378326:LtoR;ENST00000415126:LtoR;ENST000
ENST00000268852:LtoI;ENST00000378326:LtoI;ENST00000415126:LtoI;ENST00000
ENST00000359786:DtoE;ENST00000361007:DtoE;ENST00000438665:DtoE;
ENST00000318217:StoR;

ENST00000356338:VtoG;ENST00000358212:VtoG;ENST00000399229:VtoG;ENST00
ENST00000356338:VtoA;ENST00000358212:VtoA;ENST00000399229:VtoA;ENST00
ENST00000356338:LtoP;ENST00000358212:LtoP;ENST00000399229:LtoP;ENST0000
ENST00000356338:AtoT;ENST00000358212:AtoT;ENST00000399229:AtoT;ENST000

ENST00000369975:EtoG;ENST00000369977:EtoG;ENST00000369981:EtoG;ENST000

ENST00000356056:KtoE;ENST00000424560:KtoE;ENST00000444904:KtoE;ENST000
ENST00000356056:EtoG;ENST00000424560:EtoG;ENST00000444904:EtoG;ENST000
ENST00000319396:QtoK;ENST00000397274:QtoK;
ENST00000219797:LtoP;ENST00000448516:LtoP;
ENST00000259021:YtoD;ENST00000424009:YtoD;ENST00000435742:YtoD;ENST000
ENST00000287239:NtoT;ENST00000372711:NtoT;ENST00000372714:NtoT;ENST00

ENST00000356769:StoY;ENST00000393891:StoY;ENST00000435567:StoY;ENST0000
ENST00000356769:StoI;ENST00000393891:StoI;ENST00000435567:StoI;ENST00000
ENST00000356769:QtoR;ENST00000393891:QtoR;ENST00000435567:QtoR;ENST00
ENST00000356769:PtoT;ENST00000393891:PtoT;ENST00000435567:PtoT;ENST000
ENST00000356769:PtoL;ENST00000393891:PtoL;ENST00000435567:PtoL;ENST0000
ENST00000356769:GtoD;ENST00000393891:GtoD;ENST00000435567:GtoD;ENST00
ENST00000356769:EtoV;ENST00000393891:EtoV;ENST00000435567:EtoV;ENST000
ENST00000356769:EtoQ;ENST00000393891:EtoQ;ENST00000435567:EtoQ;ENST00
ENST00000356769:DtoN;ENST00000393891:DtoN;ENST00000435567:DtoN;ENST00

ENST00000240349:EtoG;
ENST00000240349:EtoG;
ENST00000240349:DtoE;

ENST00000319023:VtoG;
ENST00000319023:AtoE;

ENST00000225927:YtoH;
ENST00000225927:YtoC;
ENST00000225927:QtoH;
ENST00000225927:NtoT;
ENST00000225927:GtoS;
ENST00000380542:VtoA;ENST00000399624:VtoA;
ENST00000380542:StoF;ENST00000399624:StoF;
ENST00000380542:RtoP;ENST00000399624:RtoP;
ENST00000380542:LtoI;ENST00000399624:LtoI;
ENST00000380542:HtoY;ENST00000399624:HtoY;
ENST00000380542:HtoR;ENST00000399624:HtoR;
ENST00000380542:HtoN;ENST00000399624:HtoN;

ENST00000309794:EtoG;ENST00000345415:EtoG;ENST00000374611:EtoG;ENST000
ENST00000296543:LtoP;ENST00000398947:LtoP;

96

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+

+
+
+

+
+
+
+

+
+
+

+
+
+
+
+
+

+
+
+

AtoG
GtoT
CtoT
AtoG
AtoG
GtoA
GtoA
AtoG
GtoA
AtoG
AtoG
TtoC
TtoC
GtoA
GtoA
CtoA
CtoA
TtoC
AtoG
AtoG
CtoG
AtoT
TtoG
CtoA
AtoG
TtoA
TtoA
GtoA
TtoC
AtoC
TtoG
TtoC
TtoC
GtoA
TtoA
TtoC
AtoG
AtoG
TtoA
AtoG
AtoG
AtoG
AtoG
CtoA
TtoC
TtoG
TtoA
AtoC
TtoG
TtoC
CtoA
GtoT
AtoG
CtoA
CtoT
GtoA
AtoT
GtoC
GtoA
TtoC
AtoG
GtoA
AtoG
AtoG
TtoG
AtoG
TtoG
AtoC
TtoG
CtoA
TtoC
AtoG
TtoA
AtoG
TtoA
TtoC
AtoG
GtoC
AtoC
GtoA
TtoA
TtoC
CtoT
GtoC
CtoA
CtoT
AtoG
CtoA
AtoG
TtoC
TtoC
GtoT
CtoG
AtoG
TtoC
TtoC

0.1
0.1
0.146
0.1119
0.1
0.1
0.6364
0.1034
0.1026
0.1053
0.1
0.1
0.1065
0.1111
0.1061
0.1176
0.1667
0.1
0.1
0.1
0.1
0.125
0.1176
0.1
0.1
0.1111
0.1
0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.125
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1111
0.15
0.1
0.1
0.2
0.1
0.1034
0.125
0.1
0.1111
0.1212
0.1
0.1
0.1
0.1
0.1
0.1091
0.1818
0.1
0.1
0.1579
0.1
0.1111
0.1026
0.1053
0.1667
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1818
0.5
0.1
0.1231
0.1064
0.1562
0.1
0.1026
0.1231
0.102
0.125
0.1
0.1
0.1
0.1
0.1017
0.1
0.1

0.1111
0.1667
0.1636
0.1406
0.35
0.1333
0.7143
0.1846
0.1081
0.1111
0.1053
0.1
0.1585
0.2444
0.25
0.6
0.2
0.1333
0.1
0.1
0.125
0.125
0.2143
0.25
0.1538
0.125
0.1053
0.4
0.1
0.1
0.1429
0.1
0.1538
0.1
0.1333
0.1333
0.1333
0.125
0.1538
0.1
0.1
0.1111
0.1
0.1667
0.1111
0.1333
0.2
0.1429
0.1
0.4167
0.1
0.2
0.1591
0.2593
0.1538
0.16
0.125
0.1429
0.1818
0.2841
0.125
0.1429
0.2308
0.1
0.1667
0.3
0.1304
0.1765
0.1212
0.1818
0.3
0.1765
0.1
0.1333
0.1
0.125
0.1579
0.1667
0.2
0.5833
0.1111
0.2727
0.2222
0.4
0.25
0.3667
0.4
0.2778
0.3077
0.1333
0.1333
0.1429
0.1176
0.2857
0.1
0.1538

4
3
6
7
8
2
2
13
9
5
2
2
15
11
12
16
5
2
5
2
2
5
9
9
5
2
4
5
3
2
3
2
6
3
7
3
2
4
3
2
2
2
2
15
3
4
3
2
3
5
4
10
10
13
9
9
10
6
3
11
9
5
2
3
5
4
4
3
7
5
7
3
4
2
2
4
3
3
8
2
9
7
10
6
7
10
9
9
11
3
2
3
5
6
2
3

2
2
2
2
8
2
2
3
2
2
2
2
7
9
5
16
2
2
2
2
2
2
5
7
4
2
2
4
2
2
3
2
3
2
2
2
2
2
3
2
2
2
2
6
2
2
2
2
2
3
2
2
5
9
3
2
2
3
3
6
2
2
2
2
3
2
2
2
2
2
4
2
2
2
2
2
2
2
2
2
3
3
6
2
3
7
3
7
5
2
2
2
2
4
2
2

[10,18]
[10,12]
[55,139]
[128,295]
[10,20]
[10,15]
[11,21]
[29,65]
[38,40]
[18,19]
[10,19]
[10,10]
[77,186]
[35,65]
[25,66]
[12,203]
[10,12]
[10,15]
[10,10]
[10,10]
[10,16]
[16,16]
[10,17]
[10,18]
[10,21]
[16,18]
[10,19]
[10,14]
[10,10]
[10,10]
[10,14]
[10,20]
[10,14]
[10,10]
[10,15]
[10,15]
[15,16]
[16,18]
[10,13]
[10,10]
[10,10]
[10,10]
[10,10]
[12,69]
[18,19]
[16,18]
[15,20]
[11,14]
[10,10]
[10,21]
[20,40]
[10,30]
[44,104]
[29,100]
[29,40]
[50,66]
[16,21]
[10,17]
[10,17]
[56,223]
[10,16]
[35,55]
[11,13]
[10,10]
[10,18]
[10,20]
[23,31]
[17,27]
[33,39]
[11,19]
[11,19]
[15,17]
[10,10]
[10,15]
[10,10]
[10,16]
[10,19]
[10,12]
[11,15]
[12,13]
[18,20]
[11,65]
[18,69]
[10,32]
[10,30]
[18,81]
[10,83]
[30,49]
[13,46]
[10,15]
[10,16]
[14,21]
[17,20]
[21,59]
[10,10]
[13,20]

TableS10

chr15:58502982
chr18:53419835
chr11:77832361
chr1:45856470
chr11:34124992
chr11:34124993
chr11:34124995
chr11:63476290
chr11:63469974
chr3:114923452
chr16:3473588
chr16:3466226
chr20:19961162
chr3:47015370
chr8:91045867
chr8:91027572
chr8:91062927
chr8:91015741
chr17:38596287
chr12:6505902
chr12:6493707
chr12:6511339
chr4:17451328
chr7:158137831
chr7:158117004
chr2:96388597
chr2:96398957
chr2:96403068
chr9:99458115
chr9:99475716
chr3:198147132
chr22:35603941
chr2:105876756
chr2:105877116
chr12:53223148
chr3:48691500
chr2:232027704
chr2:232027801
chr2:232037438
chr2:24783247
chr2:24845466
chr2:24845484
chr2:24845485
chr2:24846729
chr8:71198714
chr20:45689747
chr20:45689293
chr20:45716402
chr20:45716766
chr20:45716770
chr20:45717885
chr20:32766815
chr20:32801085
chr17:15892992
chr17:15990584
chr17:15924069
chr17:15990540
chr17:15875797
chr10:112648488
chr10:112650078
chr9:135881896
chr9:135882749
chr1:158595003
chr6:90096147
chr18:2567768
chr18:2569020
chr13:79015715
chr20:34713693
chr5:149892704
chr5:149916914
chr5:149917557
chr10:75236893
chr10:75238065
chr10:75234572
chr10:75237788
chr10:75232030
chr19:5845691
chr19:19500007
chr19:19500008
chr19:59302079
chr19:59302081
chr7:10939615
chr22:40812064
chr22:40812066
chr15:39468012
chr15:39466994
chr3:49035703
chr3:49035721
chr7:140052903
chr3:121802685
chr3:121802684
chr3:121803836
chr10:102273493
chr8:125631397
chr8:125631401
chr4:140430595

NARG2
NARS
NARS2
NASP
NAT10
NAT10
NAT10
NAT11
NAT11
NAT13
NAT15
NAT15
NAT5
NBEAL2
NBN
NBN
NBN
NBN
NBR1
NCAPD2
NCAPD2
NCAPD2
NCAPG
NCAPG2
NCAPG2
NCAPH
NCAPH
NCAPH
NCBP1
NCBP1
NCBP2
NCF4
NCK2
NCK2
NCKAP1L
NCKIPSD
NCL
NCL
NCL
NCOA1
NCOA1
NCOA1
NCOA1
NCOA1
NCOA2
NCOA3
NCOA3
NCOA3
NCOA3
NCOA3
NCOA3
NCOA6
NCOA6
NCOR1
NCOR1
NCOR1
NCOR1
NCOR1
NCRNA00081
NCRNA00081
NCRNA00094
NCRNA00094
NCSTN
NCUBE1
NDC80
NDC80
NDFIP2
NDRG3
NDST1
NDST1
NDST1
NDST2
NDST2
NDST2
NDST2
NDST2
NDUFA11
NDUFA13
NDUFA13
NDUFA3
NDUFA3
NDUFA4
NDUFA6
NDUFA6
NDUFAF1
NDUFAF1
NDUFAF3
NDUFAF3
NDUFB2
NDUFB4
NDUFB4
NDUFB4
NDUFB8
NDUFB9
NDUFB9
NDUFC1

UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
mixed
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR5
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
mixed
mixed
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3

ENST00000281038:LtoS;

ENST00000338447:NtoD;ENST00000377793:NtoD;
ENST00000338447:LtoR;
ENST00000240922:StoP;ENST00000477813:StoP;ENST00000493454:StoP;ENST000
ENST00000360862:WtoR;ENST00000407558:WtoR;ENST00000414063:WtoR;ENST0
ENST00000334982:FtoI;ENST00000398602:FtoI;
ENST00000265433:VtoG;ENST00000409330:VtoG;
ENST00000265433:QtoR;ENST00000409330:QtoR;

ENST00000315579:ItoT;ENST00000382457:ItoT;
ENST00000315579:CtoW;ENST00000382457:CtoW;
ENST00000251496:EtoG;
ENST00000275830:LtoR;ENST00000356309:LtoR;ENST00000409339:LtoR;ENST000
ENST00000240423:StoR;ENST00000427946:StoR;ENST00000455200:StoR;
ENST00000240423:NtoD;ENST00000427946:NtoD;ENST00000455200:NtoD;

ENST00000294129:HtoP;ENST00000341520:HtoP;ENST00000416649:HtoP;

ENST00000452400:StoP;
ENST00000340189:QtoK;ENST00000341724:QtoK;ENST00000371997:QtoK;ENST00

ENST00000359003:VtoE;ENST00000374796:VtoE;
ENST00000359003:StoR;ENST00000374796:StoR;
ENST00000268712:StoF;ENST00000395849:StoF;ENST00000395851:StoF;ENST0000
ENST00000268712:QtoK;ENST00000395848:QtoK;ENST00000395849:QtoK;ENST00

ENST00000261597:NtoS;
ENST00000261597:CtoR;
ENST00000218652:LtoP;ENST00000377116:LtoP;
ENST00000261797:LtoR;ENST00000424060:LtoR;

ENST00000299641:StoP;ENST00000309979:StoP;ENST00000426473:StoP;
ENST00000299641:StoA;ENST00000309979:StoA;ENST00000426473:StoA;
ENST00000299641:LtoP;ENST00000309979:LtoP;
ENST00000299641:GtoE;ENST00000309979:GtoE;ENST00000426473:GtoE;

ENST00000260361:ItoV;

ENST00000184266:TtoK;ENST00000485064:TtoK;
ENST00000184266:TtoA;ENST00000485064:TtoA;

97

+
+
+
+
+
+

+
+
+
+

+
+
+
+
+

+
+
+
+
+

+
+
+
+

+
+
+
+
+

+
+
+
+
+
+

+
+
+

+
+
+

+
+
+

+
+
+
+

+
+
+
+
+
+

+
+

GtoT
TtoG
TtoC
TtoA
GtoA
AtoG
AtoC
AtoG
TtoG
TtoC
TtoC
TtoA
TtoA
TtoA
TtoG
AtoG
AtoG
AtoG
TtoC
TtoC
TtoG
AtoG
AtoG
TtoG
GtoA
TtoA
AtoG
TtoC
TtoC
AtoG
GtoA
TtoA
TtoC
TtoG
TtoA
AtoC
GtoA
GtoT
GtoA
TtoA
TtoG
TtoA
TtoG
GtoA
TtoC
CtoA
AtoG
TtoA
TtoC
TtoG
TtoC
TtoA
TtoA
CtoT
CtoA
TtoC
GtoA
TtoA
AtoT
TtoC
TtoC
AtoG
TtoG
AtoG
AtoG
TtoC
TtoC
TtoG
TtoG
GtoA
TtoC
TtoC
TtoG
TtoC
GtoA
TtoG
TtoA
GtoA
CtoA
AtoG
CtoA
AtoG
AtoG
TtoC
AtoG
TtoA
TtoA
TtoC
TtoC
CtoA
AtoG
TtoC
TtoC
TtoA
CtoA
AtoG

0.1
0.1538
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1061
0.1
0.1
0.1
0.1
0.1053
0.1
0.1364
0.1
0.1
0.1
0.1111
0.1176
0.1176
0.1
0.1111
0.1
0.125
0.1154
0.1
0.1
0.1
0.1111
0.1
0.1176
0.1
0.1
0.125
0.1
0.1667
0.1
0.1
0.1
0.1053
0.1
0.125
0.1
0.1
0.1
0.1154
0.1
0.1
0.1
0.1
0.1
0.1136
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1071
0.1
0.8696
0.1429
0.2222
0.1
0.1
0.1
0.1
0.1053
0.1
0.1538
0.1
0.12
0.1667
0.1064
0.1333
0.1
0.2083
0.1

0.1
0.1538
0.1
0.1538
0.1304
0.1429
0.1333
0.1333
0.1
0.1333
0.1
0.1176
0.1053
0.1429
0.1765
0.1429
0.1818
0.1053
0.1053
0.1667
0.1538
0.1333
0.1579
0.1
0.1765
0.1111
0.1538
0.1429
0.1
0.1
0.3
0.1579
0.125
0.3571
0.2
0.1111
0.3636
0.1111
0.2308
0.1
0.1818
0.2308
0.125
0.1
0.1429
0.1875
0.1
0.1
0.3077
0.2
0.1111
0.1
0.1818
0.1
0.1176
0.1176
0.1429
0.1818
0.1905
0.1667
0.1
0.125
0.1667
0.125
0.1176
0.1
0.1429
0.16
0.1176
0.1
0.1053
0.1
0.1
0.1333
0.1111
0.1429
0.25
0.1765
0.9259
0.2121
0.4167
0.125
0.2727
0.2727
0.1
0.1111
0.1
0.3
0.2143
0.125
0.2143
0.1364
0.1538
0.1176
0.4615
0.1538

2
6
4
4
6
6
4
2
2
7
2
2
2
5
6
2
3
2
5
2
5
2
7
3
4
2
5
7
2
5
2
5
2
4
3
2
10
3
3
2
4
7
3
2
4
3
2
2
13
5
8
6
2
2
5
4
5
2
4
4
2
2
3
4
6
2
6
5
3
3
4
4
2
3
2
2
11
11
4
5
4
3
18
11
7
5
4
4
9
3
3
6
8
3
3
8

2
2
2
2
2
2
2
2
2
2
2
2
2
2
4
2
2
2
3
2
2
2
4
2
2
2
2
2
2
2
2
2
2
3
2
2
9
2
2
2
2
3
2
2
2
2
2
2
6
2
2
2
2
2
2
2
2
2
2
3
2
2
2
3
2
2
3
2
2
2
2
2
2
2
2
2
7
7
4
2
4
2
12
6
2
2
2
4
5
2
3
2
2
2
3
2

[10,10]
[13,13]
[10,10]
[10,13]
[18,23]
[10,21]
[10,15]
[10,15]
[10,10]
[15,67]
[10,10]
[10,18]
[20,38]
[10,22]
[14,19]
[10,14]
[11,22]
[10,19]
[10,19]
[10,12]
[18,26]
[15,17]
[17,27]
[10,10]
[17,18]
[10,18]
[13,16]
[14,26]
[10,20]
[10,10]
[10,10]
[10,20]
[10,16]
[14,17]
[11,20]
[18,20]
[11,16]
[10,18]
[12,13]
[10,10]
[10,11]
[10,17]
[16,19]
[10,10]
[14,16]
[16,20]
[10,10]
[10,10]
[11,26]
[10,10]
[10,10]
[10,20]
[10,11]
[10,10]
[17,45]
[17,30]
[14,18]
[10,11]
[10,21]
[10,19]
[10,10]
[10,16]
[10,12]
[16,25]
[17,20]
[10,10]
[14,19]
[10,25]
[17,20]
[10,10]
[10,19]
[10,20]
[10,10]
[10,15]
[18,18]
[10,14]
[28,69]
[10,71]
[24,55]
[14,33]
[10,19]
[10,17]
[10,21]
[10,26]
[10,10]
[18,19]
[10,10]
[10,16]
[10,20]
[24,25]
[24,29]
[47,66]
[13,15]
[10,18]
[10,24]
[13,31]

TableS10

chr11:77468303
chr1:39272658
chr1:39267183
chr1:39272866
chr1:39264594
chr1:39264595
chr11:67560687
chr11:67136575
chr11:67130987
chr18:9124192
chr18:9124206
chr18:9114903
chr18:9114901
chr18:9114941
chr18:9114949
chr18:9114900
chr18:9124193
chr18:9124324
chr8:92040160
chr12:8135634
chr1:16659118
chr12:95862645
chr12:95854715
chr14:23755911
chr14:23771389
chr6:11300613
chr6:11300611
chr6:11291791
chr6:11292681
chr6:11293112
chr8:11681179
chr9:126154514
chr9:126154674
chr1:196488909
chr1:196555524
chr1:196556655
chr17:24092101
chr14:74640406
chr9:139462501
chr9:139462506
chr9:139462825
chr1:210686099
chr1:210686103
chr1:210686196
chr10:5490066
chr16:45714283
chr16:45675026
chr6:31935012
chr17:7168952
chr17:7162184
chr17:26656122
chr17:26727939
chr18:75322299
chr20:49482042
chr20:49438248
chr16:28874860
chr16:66758273
chr16:66714156
chr16:66782665
chr16:66782530
chr17:43483076
chr17:43483414
chr2:177803907
chr4:103733684
chr6:31634574
chr3:103054300
chr3:103057382
chr11:129245309
chr11:129239467
chr9:33284896
chr9:33322498
chr9:33361117
chr12:103038350
chr12:103037560
chr15:88610327
chr4:104190889
chr4:104187749
chr4:104187832
chr4:104198576
chr2:219648987
chr2:219649139
chr22:40399915
chr22:40399918
chr22:40400749
chr22:40400756
chr1:234206350
chr2:201470168
chr2:201468258
chr14:50280799
chr14:50291308
chr14:50256569
chr14:50257146
chr14:50257539
chr14:50258644
chr12:622937
chr15:20557777

NDUFC2
NDUFS5
NDUFS5
NDUFS5
NDUFS5
NDUFS5
NDUFS8
NDUFV1
NDUFV1
NDUFV2
NDUFV2
NDUFV2
NDUFV2
NDUFV2
NDUFV2
NDUFV2
NDUFV2
NDUFV2
NECAB1
NECAP1
NECAP2
NEDD1
NEDD1
NEDD8
NEDD8
NEDD9
NEDD9
NEDD9
NEDD9
NEDD9
NEIL2
NEK6
NEK6
NEK7
NEK7
NEK7
NEK8
NEK9
NELF
NELF
NELF
NENF
NENF
NENF
NET1
NETO2
NETO2
NEU1
NEURL4
NEURL4
NF1
NF1
NFATC1
NFATC2
NFATC2
NFATC2IP
NFATC3
NFATC3
NFATC3
NFATC3
NFE2L1
NFE2L1
NFE2L2
NFKB1
NFKBIL1
NFKBIZ
NFKBIZ
NFRKB
NFRKB
NFX1
NFX1
NFX1
NFYB
NFYB
NGRN
NHEDC2
NHEDC2
NHEDC2
NHEDC2
NHEJ1
NHEJ1
NHP2L1
NHP2L1
NHP2L1
NHP2L1
NID1
NIF3L1
NIF3L1
NIN
NIN
NIN
NIN
NIN
NIN
NINJ2
NIPA2

coding_exon
coding_exon
coding_exon
UTR3
UTR5
UTR5
UTR3
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR5
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
mixed
mixed
coding_exon
coding_exon
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
UTR5
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
mixed
mixed
UTR3
coding_exon
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon

ENST00000281031:LtoV;ENST00000324742:LtoV;
ENST00000372967:RtoP;ENST00000372969:RtoP;
ENST00000372967:LtoS;ENST00000372969:LtoS;

ENST00000318388:RtoH;ENST00000400033:RtoH;
ENST00000318388:PtoT;ENST00000400033:PtoT;
ENST00000318388:KtoN;ENST00000400033:KtoN;
ENST00000318388:KtoE;ENST00000400033:KtoE;
ENST00000318388:CtoY;ENST00000400033:CtoY;
ENST00000318388:AtoT;ENST00000400033:AtoT;

ENST00000339754:RtoS;ENST00000450991:RtoS;
ENST00000266742:EtoG;ENST00000411739:EtoG;ENST00000429527:EtoG;ENST000

ENST00000379446:VtoE;ENST00000448183:VtoE;
ENST00000379446:GtoR;ENST00000448183:GtoR;

ENST00000284503:Cto*;ENST00000354579:Cto*;ENST00000382309:Cto*;ENST000

ENST00000268766:LtoP;
ENST00000238616:CtoW;

ENST00000303155:PtoA;

ENST00000315614:VtoA;ENST00000399464:VtoA;

ENST00000329101:DtoG;ENST00000397794:DtoG;

ENST00000329524:LtoP;ENST00000346183:LtoP;ENST00000379165:LtoP;
ENST00000329524:HtoR;ENST00000346183:HtoR;ENST00000379165:HtoR;
ENST00000329524:HtoQ;ENST00000346183:HtoQ;ENST00000379165:HtoQ;

ENST00000397062:LtoP;ENST00000397063:LtoP;ENST00000446151:LtoP;

ENST00000326151:RtoT;ENST00000326172:RtoT;ENST00000394054:RtoT;
ENST00000304521:TtoP;ENST00000446488:TtoP;

ENST00000339611:LtoP;ENST00000362026:LtoP;ENST00000394785:LtoP;
ENST00000339611:GtoD;ENST00000362026:GtoD;ENST00000394785:GtoD;

ENST00000359683:VtoA;ENST00000403702:VtoA;ENST00000409020:VtoA;ENST00
ENST00000358515:ItoN;ENST00000359683:ItoN;ENST00000374679:ItoN;ENST0000
ENST00000245441:QtoR;ENST00000311149:QtoR;ENST00000324292:QtoR;ENST00

ENST00000337451:NtoS;ENST00000359727:NtoS;ENST00000398013:NtoS;ENST000

98

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+

+
+
+
+

+
+
+

+
+
+
+
+
+
+

+
+
+
+

+
+
+

+
+

CtoG
GtoC
TtoC
TtoC
TtoC
CtoT
AtoG
AtoG
CtoT
GtoA
CtoA
AtoT
AtoG
GtoA
GtoA
CtoT
CtoG
TtoA
TtoG
CtoA
GtoA
AtoG
TtoC
CtoA
TtoG
TtoA
GtoA
AtoG
TtoC
AtoG
CtoA
GtoA
TtoC
AtoC
TtoA
AtoG
TtoC
TtoG
CtoA
TtoC
CtoG
TtoC
AtoG
CtoG
AtoG
CtoG
TtoC
TtoA
TtoC
AtoC
AtoG
TtoA
AtoG
GtoA
TtoC
TtoC
TtoC
AtoG
TtoG
TtoC
AtoG
TtoC
TtoC
TtoG
TtoC
GtoC
TtoC
AtoC
TtoA
CtoA
AtoC
AtoG
TtoC
GtoA
TtoC
TtoC
GtoA
TtoG
TtoC
TtoA
TtoA
GtoT
TtoA
TtoA
TtoA
TtoG
TtoC
TtoA
AtoG
AtoG
AtoG
AtoG
AtoG
TtoC
GtoC
AtoG

0.3654
0.1053
0.1
0.1
0.1579
0.1818
0.2857
0.1
0.1
0.1
0.1176
0.1
0.1176
0.1
0.1667
0.1
0.1429
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1053
0.1538
0.1667
0.1
0.1
0.1
0.1
0.15
0.1
0.1
0.1
0.1
0.1
0.1
0.15
0.1
0.1
0.1
0.1
0.1
0.1053
0.1333
0.119
0.1
0.1
0.1
0.1053
0.1
0.1053
0.1
0.1111
0.125
0.1
0.1
0.1
0.1
0.1
0.125
0.1
0.1
0.1
0.1
0.1053
0.1154
0.1
0.1053
0.1
0.1053
0.125
0.1
0.1
0.1
0.1
0.1
0.1111

0.3871
0.1923
0.1
0.2727
0.3333
0.2857
0.3
0.2308
0.1
0.2
0.1538
0.1667
0.25
0.1538
0.5
0.2667
0.1818
0.2727
0.125
0.1111
0.2727
0.1333
0.1
0.3
0.1111
0.1429
0.1053
0.1538
0.1429
0.1
0.1
0.1667
0.1111
0.1
0.1
0.1
0.1053
0.1875
0.1
0.1111
0.1429
0.3529
0.1667
0.1667
0.1
0.1818
0.1
0.1667
0.1818
0.3846
0.1
0.1538
0.1111
0.1
0.1333
0.2308
0.1
0.25
0.1
0.1
0.2
0.1667
0.15
0.1636
0.1579
0.2
0.1
0.1333
0.1
0.25
0.1304
0.1538
0.2381
0.125
0.15
0.1
0.1
0.1111
0.3333
0.1
0.1
0.1818
0.1667
0.25
0.3
0.1111
0.1538
0.1333
0.1333
0.1818
0.1176
0.16
0.2727
0.2
0.1667
0.125

2
11
3
9
4
7
2
8
3
5
3
4
4
3
4
3
4
10
2
4
7
2
2
2
2
6
5
2
6
6
2
5
2
2
4
2
3
7
2
7
2
13
2
2
3
4
2
6
3
6
2
3
2
3
3
14
2
2
2
3
4
5
3
3
5
4
2
2
2
9
7
6
4
4
3
3
2
4
3
2
5
3
4
3
15
3
3
5
3
3
3
4
2
4
3
3

2
5
2
5
3
3
2
3
2
3
2
3
4
3
3
3
2
8
2
2
3
2
2
2
2
2
2
2
2
2
2
4
2
2
2
2
2
3
2
3
2
6
2
2
2
2
2
3
2
3
2
2
2
2
2
2
2
2
2
2
4
2
2
2
3
2
2
2
2
6
4
3
3
2
2
2
2
2
2
2
2
2
3
2
6
2
2
2
2
2
2
2
2
3
3
2

[31,52]
[16,28]
[10,10]
[10,20]
[12,19]
[11,18]
[10,14]
[10,18]
[10,10]
[10,20]
[13,17]
[10,13]
[13,17]
[10,13]
[10,12]
[10,15]
[11,14]
[10,19]
[10,17]
[10,20]
[10,14]
[10,15]
[10,20]
[10,10]
[10,27]
[14,20]
[19,20]
[10,13]
[10,14]
[10,20]
[10,10]
[12,19]
[10,20]
[10,10]
[10,11]
[10,10]
[19,20]
[16,20]
[10,10]
[10,99]
[10,15]
[11,19]
[13,13]
[12,12]
[10,10]
[10,11]
[10,20]
[10,12]
[11,20]
[10,20]
[10,10]
[10,13]
[18,20]
[10,10]
[10,15]
[13,20]
[10,10]
[10,12]
[10,10]
[10,10]
[10,21]
[13,19]
[15,20]
[42,55]
[10,27]
[10,10]
[10,10]
[15,19]
[10,10]
[12,38]
[10,23]
[13,19]
[17,21]
[10,16]
[10,20]
[10,10]
[10,10]
[10,10]
[12,16]
[10,10]
[10,10]
[10,11]
[10,13]
[12,19]
[10,26]
[10,11]
[14,19]
[10,15]
[15,19]
[11,16]
[10,17]
[10,25]
[11,11]
[12,20]
[10,16]
[16,18]

TableS10

chr15:20563876
NIPA2
chr15:20557950
NIPA2
chr15:20565926
NIPA2
chr1:24671905
NIPAL3
chr3:52501435
NISCH
chr3:52481015
NISCH
chr3:52490878
NISCH
chr1:159357027
NIT1
chr3:42636164
NKTR
chr17:30483533
NLE1
chr17:23543339
NLK
chr16:55619717
NLRC5
chr16:55580997
NLRC5
chr16:55581002
NLRC5
chr11:118559492
NLRX1
chr11:118559743
NLRX1
chr3:162452493
NMD3
chr17:46594388 NME1NME2
chr17:46603929
NME2
chr17:46603950
NME2
chr17:46603864
NME2
chr17:46602409
NME2
chr17:46602330
NME2
chr17:46602408
NME2
chr17:46603858
NME2
chr17:46603860
NME2
chr17:46603940
NME2
chr17:46603942
NME2
chr17:46603847
NME2
chr17:46603919
NME2
chr17:46604046
NME2
chr17:46604104
NME2
chr17:46604105
NME2
chr3:48311007
NME6
chr1:167368583
NME7
chr2:151835413
NMI
chr1:9965342
NMNAT1
chr17:40540826
NMT1
chr17:40541026
NMT1
chr17:40541830
NMT1
chr10:15223471
NMT2
chr5:43648945
NNT
chr5:43680052
NNT
chr5:43740530
NNT
chr5:43740639
NNT
chr5:43741104
NNT
chr10:96084389
NOC3L
chr10:96087574
NOC3L
chr10:96083906
NOC3L
chr7:30439275
NOD1
chr16:49303343
NOD2
chr16:49324170
NOD2
chr16:49324225
NOD2
chr22:36414910
NOL12
chr16:65766648
NOL3
chr9:33452621
NOL6
chr9:33451626
NOL6
chr9:33451630
NOL6
chr6:13728970
NOL7
chr6:13728528
NOL7
chr6:13729988
NOL7
chr6:13730111
NOL7
chr6:13729148
NOL7
chr9:94109124
NOL8
chr1:6508497
NOL9
chr10:103909297
NOLC1
chr7:156449363
NOM1
chr7:156445439
NOM1
chr7:156455078
NOM1
chr7:156449362
NOM1
chr5:175743705
NOP16
chr5:175743702
NOP16
chr5:175743706
NOP16
chr5:175743703
NOP16
chr12:6536312
NOP2
chr20:2586685
NOP56
chr2:202857446
NOP58
chr19:54750786
NOSIP
chr9:138509118
NOTCH1
chr11:107538114
NPAT
chr18:19366129
NPC1
chr20:56721883
NPEPL1
chr20:56721884
NPEPL1
chr20:56721999
NPEPL1
chr20:56723986
NPEPL1
chr17:43046067
NPEPPS
chr17:43054476
NPEPPS
chr17:43055387
NPEPPS
chr3:133759900
NPHP3
chr3:133760494
NPHP3
chr3:133760513
NPHP3
chr3:133804775
NPHP3
chr5:170751007
NPM1
chr5:170747595
NPM1
chr5:170770160
NPM1
chr5:170751378
NPM1

coding_exon
coding_exon
coding_exon
UTR3
coding_exon
mixed
mixed
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR5
UTR5
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
mixed
UTR3
UTR3
coding_exon
coding_exon
mixed
mixed
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon

ENST00000337451:ItoV;ENST00000359727:ItoV;ENST00000398013:ItoV;ENST0000

ENST00000345716:VtoG;ENST00000433196:VtoG;ENST00000479054:VtoG;

ENST00000368007:WtoR;ENST00000368009:WtoR;
ENST00000232978:NtoK;ENST00000442970:NtoK;
ENST00000262393:QtoR;ENST00000407008:QtoR;
ENST00000262510:Lto*;ENST00000308149:Lto*;ENST00000436936:Lto*;

ENST00000393185:YtoH;ENST00000393190:YtoH;ENST00000393191:YtoH;ENST000
ENST00000393185:WtoR;ENST00000393190:WtoR;ENST00000393191:WtoR;ENST0
ENST00000393185:StoN;ENST00000393190:StoN;ENST00000393191:StoN;ENST000
ENST00000393185:RtoK;ENST00000393190:RtoK;ENST00000393191:RtoK;ENST000
ENST00000393185:RtoG;ENST00000393190:RtoG;ENST00000393191:RtoG;ENST00
ENST00000393185:RtoG;ENST00000393190:RtoG;ENST00000393191:RtoG;ENST00
ENST00000393185:HtoR;ENST00000393190:HtoR;ENST00000393191:HtoR;ENST00
ENST00000393185:GtoS;ENST00000393190:GtoS;ENST00000393191:GtoS;ENST000
ENST00000393185:Cto*;ENST00000393190:Cto*;ENST00000393191:Cto*;ENST000
ENST00000393185:AtoD;ENST00000393190:AtoD;ENST00000393191:AtoD;ENST00

ENST00000377205:TtoR;

ENST00000371350:KtoE;ENST00000371361:KtoE;

ENST00000300589:TtoP;

ENST00000359114:StoP;

ENST00000451315:QtoK;
ENST00000451315:NtoD;

ENST00000358855:VtoA;ENST00000360868:VtoA;ENST00000375594:VtoA;ENST00
ENST00000370007:PtoT;ENST00000405356:PtoT;ENST00000429062:PtoT;
ENST00000275820:StoG;
ENST00000275820:LtoP;
ENST00000275820:AtoT;
ENST00000341213:HtoQ;ENST00000451293:HtoQ;
ENST00000341213:HtoP;ENST00000451293:HtoP;
ENST00000341213:HtoP;ENST00000451293:HtoP;
ENST00000341213:HtoN;ENST00000451293:HtoN;
ENST00000329276:KtoN;
ENST00000264279:HtoP;

ENST00000278612:KtoR;
ENST00000371131:DtoN;
ENST00000356091:TtoP;ENST00000371131:DtoA;
ENST00000356091:GtoE;
ENST00000322157:TtoA;

ENST00000296930:TtoA;ENST00000351986:TtoA;ENST00000393820:TtoA;
ENST00000296930:RtoM;ENST00000351986:RtoM;ENST00000393820:RtoM;
ENST00000296930:RtoG;ENST00000351986:RtoG;
ENST00000296930:PtoT;ENST00000351986:PtoT;ENST00000393820:PtoT;

99

+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+

+
+
+
+
+

+
+
+
+
+

+
+
+
+
+

+
+
+
+
+

+
+

+
+
+
+
+
+
+

+
+
+
+

AtoG
TtoA
AtoC
TtoC
TtoG
TtoC
GtoC
TtoC
TtoA
TtoC
AtoG
TtoG
CtoG
GtoT
CtoG
TtoC
TtoA
TtoC
TtoC
TtoC
GtoA
GtoA
CtoG
AtoG
AtoG
GtoA
TtoA
CtoA
GtoA
AtoG
AtoG
AtoG
CtoA
TtoC
AtoT
AtoG
CtoG
TtoG
GtoC
TtoC
TtoC
TtoG
TtoA
AtoC
TtoA
AtoG
AtoG
TtoC
TtoC
AtoT
AtoC
AtoG
TtoA
TtoC
TtoC
TtoC
AtoG
TtoC
CtoA
AtoG
AtoG
TtoC
AtoT
TtoC
TtoC
CtoA
AtoG
TtoC
GtoA
CtoA
CtoA
AtoC
AtoC
CtoA
AtoG
AtoC
AtoC
TtoC
TtoC
AtoG
AtoG
GtoA
AtoC
GtoA
TtoC
AtoG
AtoG
AtoC
AtoG
AtoC
AtoG
TtoA
AtoG
GtoT
AtoG
CtoA

0.1818
0.1
0.1633
0.1
0.1176
0.1176
0.1
0.1053
0.1
0.1071
0.1
0.1
0.3571
0.3182
0.1
0.1
0.1667
0.1
0.1333
0.1
0.1176
0.1429
0.1013
0.1
0.1429
0.1111
0.1
0.1
0.1
0.1
0.1005
0.1266
0.8929
0.1
0.1
0.1111
0.1
0.1053
0.2963
0.12
0.1
0.1
0.1
0.1
0.1
0.1111
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1429
0.1
0.1053
0.1
0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1111
0.1
0.1
0.1176
0.3462
0.1538
0.3462
0.1333
0.1053
0.1667
0.1053
0.1
0.1
0.1
0.1
0.1176
0.125
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.12
0.1034
0.1
0.1212

0.1923
0.1176
0.1892
0.1
0.3
0.2143
0.1
0.125
0.1
0.1875
0.1818
0.1875
0.4615
0.4667
0.1
0.1667
0.1667
0.2963
0.4
0.1818
0.125
0.1613
0.1111
0.1379
0.2727
0.3
0.1667
0.1333
0.2759
0.25
0.1015
0.1333
1
0.1111
0.1111
0.2727
0.1
0.1071
1
0.1212
0.1818
0.3125
0.1818
0.1111
0.1
0.125
0.15
0.1364
0.1
0.1
0.1
0.1667
0.1
0.2
0.1818
0.1176
0.1905
0.2
0.2308
0.1
0.129
0.2143
0.1
0.1212
0.15
0.1667
0.2308
0.2
0.1818
0.2143
0.5
0.25
0.5
0.3333
0.2
0.1818
0.3077
0.1111
0.1
0.1
0.1
0.2143
0.1333
0.1
0.1333
0.2143
0.125
0.2308
0.1154
0.1
0.1053
0.125
0.2963
0.1379
0.25
0.1923

7
2
4
3
5
3
2
5
2
2
2
5
2
2
2
2
2
21
3
3
2
8
11
10
3
2
3
2
13
5
17
11
7
3
2
7
2
3
3
4
2
8
3
2
2
7
8
5
2
2
2
2
2
3
3
2
9
7
7
2
7
7
2
3
4
8
7
2
3
6
4
3
3
6
5
2
5
4
3
2
3
6
3
2
5
4
2
6
7
2
3
2
9
7
8
8

4
2
2
2
2
2
2
2
2
2
2
4
2
2
2
2
2
16
2
2
2
3
2
2
2
2
2
2
8
3
2
3
7
2
2
3
2
2
3
2
2
4
2
2
2
2
2
3
2
2
2
2
2
2
2
2
4
2
2
2
2
3
2
2
2
2
5
2
2
4
4
2
3
5
2
2
5
2
2
2
2
4
2
2
2
2
2
3
2
2
2
2
4
2
5
3

[11,26]
[10,17]
[37,49]
[10,10]
[10,17]
[14,17]
[10,10]
[19,24]
[10,10]
[16,28]
[10,12]
[16,29]
[13,14]
[15,22]
[10,10]
[10,12]
[12,12]
[18,90]
[11,16]
[11,11]
[16,18]
[20,31]
[74,79]
[30,50]
[12,14]
[10,11]
[10,13]
[10,15]
[15,72]
[10,15]
[191,199]
[46,80]
[19,65]
[10,10]
[10,18]
[10,11]
[10,10]
[19,28]
[21,27]
[25,33]
[10,11]
[10,21]
[10,11]
[10,27]
[10,10]
[16,18]
[16,20]
[10,23]
[10,10]
[10,10]
[10,10]
[10,12]
[10,10]
[10,17]
[11,14]
[10,17]
[16,21]
[10,10]
[13,17]
[10,10]
[10,34]
[10,14]
[10,10]
[10,33]
[20,20]
[30,36]
[10,18]
[10,10]
[10,11]
[14,17]
[10,26]
[12,13]
[10,26]
[10,18]
[15,19]
[11,12]
[13,25]
[18,20]
[10,11]
[10,10]
[10,10]
[14,17]
[15,16]
[10,10]
[15,19]
[14,20]
[10,16]
[13,21]
[10,26]
[10,10]
[10,19]
[10,16]
[25,52]
[29,30]
[10,19]
[28,90]

TableS10

chr5:170751345
chr5:170747598
chr5:170747592
chr5:170751002
chr5:170770139
chr5:170751328
chr5:170751376
chr5:170747596
chr5:170751006
chr5:170751024
chr5:170751347
chr5:170770300
chr5:170770306
chr5:170770442
chr5:170770476
chr5:170770477
chr5:170770479
chr5:170747465
chr15:71639466
chr15:71639812
chr6:2962216
chr19:55573647
chr19:55573644
chr19:55573634
chr19:55571594
chr3:15054552
chr19:19174658
chr19:19174310
chr19:19174352
chr5:142655220
chr5:142655274
chr5:142641094
chr5:142638962
chr11:124121996
chr14:23642774
chr6:30763820
chr20:278348
chr5:176653762
chr5:176655302
chr5:176655783
chr5:176659396
chr17:42161411
chr20:1374320
chr8:59658905
chr16:27143830
chr8:126232658
chr8:126232653
chr8:126173379
chr10:123706726
chr1:46598991
chr1:46600761
chr10:104849682
chr10:104850831
chr10:104839310
chr17:37235042
chr16:15039446
chr16:2033595
chr11:17308263
chr1:203953146
chr1:203953555
chr1:203953813
chr1:203953814
chr1:203949054
chr1:203949072
chr1:203952434
chr1:203952496
chr1:203953037
chr1:27145470
chr1:27145471
chr5:162813581
chr7:44389875
chr7:2257206
chr9:34333284
chr9:34333653
chr4:88598079
chr4:88598237
chr17:24638835
chr17:24615282
chr12:67411668
chr12:67390075
chr1:227660553
chr6:17723728
chr5:37335388
chr11:47791133
chr11:47758561
chr7:134923150
chr7:134954899
chr7:134983881
chr3:13370113
chr9:132995988
chr12:100992271
chr12:101030027
chr6:150087186
chr6:150088781
chr6:150089384
chr17:70743401

NPM1
NPM1
NPM1
NPM1
NPM1
NPM1
NPM1
NPM1
NPM1
NPM1
NPM1
NPM1
NPM1
NPM1
NPM1
NPM1
NPM1
NPM1
NPTN
NPTN
NQO2
NR1H2
NR1H2
NR1H2
NR1H2
NR2C2
NR2C2AP
NR2C2AP
NR2C2AP
NR3C1
NR3C1
NR3C1
NR3C1
NRGN
NRL
NRM
NRSN2
NSD1
NSD1
NSD1
NSD1
NSF
NSFL1C
NSMAF
NSMCE1
NSMCE2
NSMCE2
NSMCE2
NSMCE4A
NSUN4
NSUN4
NT5C2
NT5C2
NT5C2
NT5C3L
NTAN1
NTHL1
NUCB2
NUCKS1
NUCKS1
NUCKS1
NUCKS1
NUCKS1
NUCKS1
NUCKS1
NUCKS1
NUCKS1
NUDC
NUDC
NUDCD2
NUDCD3
NUDT1
NUDT2
NUDT2
NUDT9
NUDT9
NUFIP2
NUFIP2
NUP107
NUP107
NUP133
NUP153
NUP155
NUP160
NUP160
NUP205
NUP205
NUP205
NUP210
NUP214
NUP37
NUP37
NUP43
NUP43
NUP43
NUP85

coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR5
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR5
UTR3
coding_exon
mixed
mixed
mixed
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3

ENST00000296930:PtoS;ENST00000351986:PtoS;ENST00000393820:PtoS;
ENST00000296930:PtoR;ENST00000351986:PtoR;ENST00000393820:PtoR;
ENST00000296930:LtoQ;ENST00000351986:LtoQ;ENST00000393820:LtoQ;
ENST00000296930:LtoP;ENST00000351986:LtoP;ENST00000393820:LtoP;
ENST00000296930:ItoV;ENST00000351986:ItoV;
ENST00000296930:GtoV;ENST00000351986:GtoV;ENST00000393820:GtoV;
ENST00000296930:GtoE;ENST00000351986:GtoE;ENST00000393820:GtoE;

ENST00000338130:Qto*;ENST00000380430:Qto*;ENST00000380441:Qto*;ENST00
ENST00000253727:StoA;ENST00000376942:StoA;ENST00000411902:StoA;
ENST00000253727:EtoQ;ENST00000376942:EtoQ;ENST00000411902:EtoQ;

ENST00000323373:ItoL;ENST00000383792:ItoL;ENST00000393102:ItoL;ENST00000
ENST00000331552:QtoR;ENST00000420605:QtoR;

ENST00000231509:StoL;ENST00000343796:StoL;ENST00000394464:StoL;ENST0000
ENST00000231509:LtoR;ENST00000343796:LtoR;ENST00000394464:LtoR;ENST000

ENST00000246039:KtoE;ENST00000382285:KtoE;ENST00000382291:KtoE;
ENST00000347982:StoP;ENST00000354179:StoP;ENST00000355783:StoP;ENST000

ENST00000398238:VtoA;
ENST00000216879:HtoP;ENST00000350991:HtoP;ENST00000353088:HtoP;ENST00

ENST00000287437:QtoR;

ENST00000474844:DtoA;

ENST00000219066:VtoG;
ENST00000323688:QtoR;ENST00000405119:QtoR;ENST00000458064:QtoR;

ENST00000337747:EtoG;ENST00000346365:EtoG;ENST00000379154:EtoG;ENST000
ENST00000302174:VtoA;ENST00000358033:VtoA;ENST00000440591:VtoA;

ENST00000229179:TtoA;
ENST00000229179:StoR;ENST00000378905:StoR;
ENST00000261396:DtoE;ENST00000366679:DtoE;ENST00000366681:DtoE;
ENST00000231498:CtoR;ENST00000381843:CtoR;ENST00000434056:CtoR;
ENST00000263764:LtoP;ENST00000378460:LtoP;
ENST00000285968:EtoA;

ENST00000254508:TtoP;
ENST00000354226:KtoE;ENST00000359428:KtoE;ENST00000411637:KtoE;ENST000

100

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+

+
+
+
+
+
+

+
+
+

+
+

+
+

+
+
+
+
+

+
+

+
+
+

CtoT
CtoG
TtoA
TtoC
AtoG
GtoT
GtoA
GtoA
AtoG
AtoC
AtoT
TtoC
TtoA
TtoC
CtoG
AtoG
TtoA
TtoG
AtoG
TtoC
CtoT
TtoG
GtoC
AtoG
TtoG
AtoC
AtoG
TtoC
CtoA
CtoT
TtoG
TtoG
TtoC
AtoG
AtoC
TtoC
AtoG
TtoC
AtoT
CtoT
AtoG
TtoC
AtoC
GtoA
TtoC
AtoG
TtoC
CtoA
AtoG
AtoC
AtoG
TtoG
GtoC
GtoA
GtoA
AtoG
TtoG
AtoG
CtoA
AtoC
GtoC
AtoT
CtoG
TtoC
TtoA
TtoC
TtoA
CtoA
AtoG
TtoC
AtoC
AtoC
AtoG
AtoG
TtoC
AtoG
TtoC
TtoA
AtoG
TtoA
TtoA
AtoG
TtoC
TtoC
AtoG
AtoC
AtoG
TtoG
AtoC
AtoG
TtoA
TtoC
AtoG
AtoG
TtoG
AtoG

0.1154
0.1
0.1136
0.1408
0.25
0.1053
0.1132
0.1111
0.18
0.1
0.1
0.1622
0.1429
0.108
0.1333
0.12
0.2727
0.1538
0.1111
0.1
0.1
0.1
0.12
0.1
0.1026
0.1
0.1053
0.1176
0.1
0.1667
0.1
0.1111
0.1
0.1
0.1077
0.1
0.1667
0.1
0.1111
0.1
0.1667
0.1053
0.1224
0.125
0.1053
0.1053
0.1
0.1429
0.1111
0.1429
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1026
0.1111
0.1818
0.1304
0.1
0.1429
0.1
0.1111
0.1
0.1
0.1333
0.1667
0.1034
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1111
0.1
0.1176
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1304
0.1667
0.1
0.1
0.2

0.1207
0.1176
0.28
0.28
0.25
0.125
0.1923
0.2105
0.3793
0.1
0.1111
0.2083
0.2581
0.1569
0.5882
0.2
0.6923
0.1667
0.1538
0.1111
0.1
0.3
0.4
0.1667
0.25
0.1
0.1111
0.125
0.1538
0.3
0.12
0.1818
0.1316
0.1333
0.1351
0.1389
0.2308
0.1333
0.1429
0.1
0.2
0.1333
0.1607
0.1818
0.1111
0.125
0.1
0.2
0.3
0.1765
0.1
0.2
0.1
0.1176
0.1333
0.1
0.3
0.2
0.4
0.2
0.1429
0.1613
0.3846
0.125
0.1667
0.125
0.1
0.1538
0.2143
0.125
0.1818
0.1944
0.12
0.1667
0.1667
0.1
0.1111
0.1818
0.2
0.1333
0.2
0.1429
0.1429
0.1333
0.1333
0.1111
0.1
0.1
0.2308
0.1667
0.125
0.1818
0.2
0.1176
0.1
0.3333

2
6
7
14
7
8
10
9
6
5
2
6
3
15
15
8
5
5
5
4
2
4
10
6
12
2
2
3
2
3
11
4
4
2
3
5
4
2
2
2
7
2
4
4
8
7
3
6
11
3
2
2
2
2
4
2
4
4
2
2
5
6
3
3
3
7
2
3
7
5
3
6
3
3
11
3
3
4
3
5
4
3
3
2
3
3
2
4
5
9
8
4
2
6
2
4

2
2
5
13
2
2
4
4
6
2
2
4
3
5
15
2
5
2
3
2
2
3
10
5
6
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
3
2
3
2
2
2
2
2
2
2
2
3
3
2
2
3
3
2
3
2
2
2
2
4
2
3
4
2
2
3
2
2
2
2
2
2
3
2
2
2
2
2
2
3
2
2
2
2
2
2
4

[52,60]
[10,18]
[18,48]
[50,210]
[12,24]
[24,38]
[27,90]
[18,27]
[51,79]
[10,20]
[47,61]
[25,50]
[14,31]
[180,351]
[13,67]
[25,25]
[12,20]
[12,26]
[10,18]
[10,10]
[10,10]
[10,14]
[10,32]
[10,30]
[11,70]
[10,10]
[18,19]
[16,17]
[10,13]
[10,12]
[10,25]
[10,11]
[30,38]
[10,15]
[37,65]
[10,36]
[12,13]
[10,15]
[15,18]
[10,10]
[10,12]
[15,19]
[49,56]
[11,16]
[18,19]
[16,24]
[10,20]
[10,20]
[10,36]
[14,17]
[10,10]
[10,15]
[10,10]
[10,17]
[10,15]
[10,10]
[10,14]
[10,40]
[10,18]
[10,12]
[21,36]
[19,31]
[13,21]
[10,20]
[12,18]
[30,32]
[10,10]
[13,15]
[11,18]
[29,32]
[10,15]
[11,36]
[25,30]
[10,12]
[18,18]
[10,10]
[10,18]
[10,11]
[10,18]
[10,15]
[10,17]
[10,14]
[14,20]
[18,30]
[10,15]
[10,10]
[10,10]
[10,10]
[10,60]
[10,12]
[16,18]
[11,23]
[12,20]
[10,17]
[10,10]
[10,12]

TableS10

chr17:5230180
chr11:3653978
chr11:3657376
chr11:3757032
chr13:24812650
chr13:24813524
chr7:23206862
chr6:118103927
chr15:39460509
chr16:66462702
chr16:66462705
chr12:111932908
chr12:111895102
chr2:192254965
chr9:130302513
chr9:130302572
chr22:49316866
chr22:49316870
chr22:49315726
chr7:44715083
chr16:55053975
chr16:55066926
chr12:122029055
chr12:122028963
chr12:122030029
chr15:39411427
chr3:194855475
chr3:194815506
chr19:50748775
chr19:50744316
chr1:239823978
chr1:239824338
chr10:13192463
chr10:13194567
chr12:120564064
chr7:101873984
chr7:101878972
chr16:30873049
chr11:69189699
chr1:52631997
chr1:52626856
chr2:201498899
chr2:201483790
chr2:148446786
chr2:148412431
chr2:148409466
chr2:190344397
chr2:190355700
chr11:59102378
chr11:59105546
chr11:59099624
chr20:60302720
chr20:60303144
chr7:24816017
chr7:24821320
chr7:24822809
chr7:24804427
chr17:43241232
chr14:19987012
chr14:19985241
chr14:19985091
chr2:190326944
chr3:197445857
chr3:197449712
chr3:197449729
chr4:109798066
chr4:109796232
chr4:109807891
chr4:109807910
chr4:109808118
chr4:109808341
chr8:92159833
chr1:148182961
chr20:17919727
chr14:22310553
chr14:22310803
chr5:41766534
chr5:41767521
chr3:25810730
chr3:25810599
chr3:38271213
chr3:38271712
chr12:120156281
chr19:10086697
chr19:10086699
chr10:74480958
chr10:74437730
chr3:49013988
chr3:49002973
chr12:54793342
chr12:54793595
chr12:54793931
chr11:73298236
chr1:39799098
chr8:101791134
chr8:101791112

NUP88
NUP98
NUP98
NUP98
NUPL1
NUPL1
NUPL2
NUS1
NUSAP1
NUTF2
NUTF2
OAS2
OAS3
OBFC2A
ODF2
ODF2
ODF3B
ODF3B
ODF3B
OGDH
OGFOD1
OGFOD1
OGFOD2
OGFOD2
OGFOD2
OIP5
OPA1
OPA1
OPA3
OPA3
OPN3
OPN3
OPTN
OPTN
ORAI1
ORAI2
ORAI2
ORAI3
ORAOV1
ORC1L
ORC1L
ORC2L
ORC2L
ORC4L
ORC4L
ORC4L
ORMDL1
ORMDL1
OSBP
OSBP
OSBP
OSBPL2
OSBPL2
OSBPL3
OSBPL3
OSBPL3
OSBPL3
OSBPL7
OSGEP
OSGEP
OSGEP
OSGEPL1
Osta
Osta
Osta
OSTC
OSTC
OSTC
OSTC
OSTC
OSTC
OTUD6B
OTUD7B
OVOL2
OXA1L
OXA1L
OXCT1
OXCT1
OXSM
OXSM
OXSR1
OXSR1
P2RX4
P2RY11
P2RY11
P4HA1
P4HA1
P4HTM
P4HTM
PA2G4
PA2G4
PA2G4
PAAF1
PABPC4
PABPCP5
PABPCP5

UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
mixed
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR5
coding_exon
coding_exon
UTR3
UTR3
UTR3
mixed
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
mixed
mixed
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
mixed
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon

ENST00000324932:VtoG;ENST00000355260:VtoG;
ENST00000324932:LtoP;ENST00000355260:LtoP;ENST00000359171:LtoP;

ENST00000368494:VtoD;

ENST00000401779:WtoR;ENST00000456888:WtoR;
ENST00000329363:GtoA;ENST00000405135:GtoA;ENST00000428989:GtoA;ENST00

ENST00000336111:WtoR;
ENST00000336111:EtoG;
ENST00000228922:MtoV;ENST00000397389:MtoV;ENST00000406539:MtoV;ENST0

ENST00000220514:ItoV;
ENST00000361150:WtoR;ENST00000361510:WtoR;ENST00000361715:WtoR;ENST0
ENST00000263275:VtoA;

ENST00000263036:KtoR;ENST00000378747:KtoR;ENST00000378748:KtoR;ENST000
ENST00000263036:ItoV;ENST00000378747:ItoV;ENST00000378748:ItoV;ENST0000
ENST00000356387:QtoR;ENST00000403646:QtoR;ENST00000458233:QtoR;ENST00

ENST00000371566:KtoT;ENST00000371568:KtoT;
ENST00000371566:ItoS;ENST00000371568:ItoS;
ENST00000234296:VtoA;
ENST00000264169:KtoE;ENST00000392857:KtoE;ENST00000392858:KtoE;

ENST00000263847:VtoA;ENST00000378235:VtoA;
ENST00000263847:TtoI;ENST00000378235:TtoI;

ENST00000007414:QtoR;
ENST00000206542:ItoV;
ENST00000206542:*toK;

ENST00000361564:QtoR;
ENST00000361564:HtoR;

ENST00000285420:AtoD;ENST00000404789:AtoD;
ENST00000369135:KtoE;

ENST00000280701:LtoH;ENST00000420173:LtoH;

ENST00000343546:StoC;ENST00000383729:StoC;ENST00000416619:StoC;
ENST00000343546:GtoR;ENST00000383729:GtoR;ENST00000416619:GtoR;

ENST00000310571:VtoG;ENST00000376384:VtoG;
ENST00000318607:VtoA;ENST00000347137:VtoA;
ENST00000318607:StoR;ENST00000347137:StoR;

101

+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+

+
+

+
+
+
+
+
+

+
+

+
+
+
+
+
+
+
+
+
+

+
+

+
+
+
+
+
+
+

+
+
+
+
+
+

TtoC
TtoG
TtoC
AtoG
TtoA
AtoG
TtoC
TtoA
TtoC
CtoA
AtoG
AtoT
TtoG
TtoC
AtoG
TtoG
TtoA
GtoC
TtoC
CtoA
TtoC
AtoG
AtoG
TtoA
TtoC
AtoG
TtoC
TtoG
TtoC
AtoG
TtoC
AtoG
AtoG
AtoG
GtoA
AtoG
TtoC
AtoT
TtoC
AtoC
TtoG
TtoC
TtoC
AtoG
TtoC
TtoA
AtoG
TtoC
TtoC
CtoT
GtoA
AtoG
GtoT
TtoG
AtoT
TtoC
TtoA
AtoG
AtoG
TtoA
TtoC
TtoC
AtoT
TtoG
AtoT
AtoG
AtoG
AtoG
CtoA
AtoG
AtoG
CtoA
AtoG
TtoC
TtoC
AtoG
TtoC
AtoG
TtoA
TtoA
GtoT
AtoG
TtoC
AtoT
TtoC
TtoA
GtoA
AtoT
GtoA
TtoC
GtoA
AtoG
TtoG
TtoA
TtoC
CtoA

0.1
0.1333
0.1333
0.1
0.1429
0.1
0.1
0.1053
0.1765
0.1538
0.1579
0.1
0.1136
0.2727
0.1176
0.1
0.2727
0.1538
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1034
0.1
0.1
0.1
0.1
0.1
0.1034
0.1538
0.1
0.1053
0.1
0.1
0.1
0.1667
0.1
0.1
0.1
0.1
0.1538
0.1
0.1
0.1489
0.2
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.122
0.1091
0.1
0.1
0.1
0.1
0.1111
0.1111
0.1
0.2
0.1111
0.1
0.1

0.1667
0.2
0.1538
0.1
0.1667
0.1111
0.1
0.1579
0.25
0.2
0.3636
0.1
0.2
0.3333
0.1667
0.125
0.625
0.2
0.1667
0.1538
0.1364
0.1
0.1176
0.1053
0.1667
0.1579
0.2
0.1667
0.1
0.1053
0.1
0.2
0.1538
0.1111
0.1667
0.1
0.1
0.1
0.2
0.1667
0.1
0.2
0.1111
0.1818
0.1053
0.125
0.1304
0.1
0.1
0.1
0.1
0.1538
0.1053
0.1111
0.1364
0.25
0.1
0.1
0.1154
0.1429
0.25
0.1667
0.1111
0.1875
0.1
0.2727
0.2
0.1
0.1304
0.3333
0.1111
0.1538
0.1
0.1
0.2297
0.25
0.1538
0.1
0.1
0.1
0.1765
0.1351
0.1
0.1364
0.2222
0.1176
0.1053
0.1
0.1
0.1667
0.25
0.1538
0.3636
0.1429
0.1176
0.2143

3
3
5
7
6
4
2
2
6
9
6
3
6
4
4
3
3
2
3
2
4
4
2
3
2
2
5
2
2
4
3
3
3
4
6
2
2
5
2
2
2
4
3
2
6
6
7
5
2
3
2
3
2
8
2
5
2
2
5
6
6
3
5
3
3
9
5
5
2
14
2
3
2
2
5
2
3
3
3
2
6
2
3
4
2
4
5
2
2
5
2
3
8
2
8
12

2
2
2
2
2
2
2
2
4
3
5
2
5
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
3
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
4
2
3
2
11
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
3
2
2
2
3
2
2
2
2
2
6

[10,12]
[10,15]
[13,15]
[10,11]
[12,14]
[10,18]
[10,20]
[19,19]
[10,19]
[10,20]
[13,22]
[10,10]
[19,45]
[11,12]
[12,17]
[10,24]
[11,16]
[10,13]
[12,20]
[13,19]
[10,22]
[10,10]
[10,18]
[10,20]
[10,12]
[10,19]
[10,10]
[10,13]
[10,10]
[19,20]
[10,10]
[10,10]
[10,13]
[18,40]
[12,17]
[20,20]
[10,10]
[10,10]
[10,10]
[10,12]
[10,10]
[10,15]
[10,18]
[11,15]
[10,19]
[10,16]
[20,23]
[10,10]
[10,10]
[10,10]
[10,10]
[10,13]
[10,19]
[18,29]
[10,22]
[10,12]
[10,10]
[10,10]
[26,30]
[21,30]
[12,13]
[10,12]
[18,19]
[16,20]
[10,20]
[10,25]
[15,18]
[10,10]
[10,25]
[10,56]
[10,18]
[13,13]
[10,10]
[10,10]
[47,75]
[10,12]
[13,16]
[10,10]
[10,10]
[10,10]
[14,20]
[20,37]
[10,10]
[22,43]
[27,55]
[10,17]
[10,19]
[10,10]
[10,10]
[12,18]
[12,18]
[10,13]
[10,11]
[14,18]
[18,31]
[20,41]

TableS10

chr8:101791113
PABPCP5
chr8:101794519
PABPCP5
chr8:101794520
PABPCP5
chr8:101786343
PABPCP5
chr8:101790566
PABPCP5
chr8:101794063
PABPCP5
chr8:101786337
PABPCP5
chr8:101790554
PABPCP5
chr8:101799637
PABPCP5
chr8:101799636
PABPCP5
chr8:101786358
PABPCP5
chr8:101793767
PABPCP5
chr8:101793766
PABPCP5
chr8:101791111
PABPCP5
chr8:101793825
PABPCP5
chr8:101791105
PABPCP5
chr8:101796895
PABPCP5
chr8:101796896
PABPCP5
chr8:101793816
PABPCP5
chr8:101785787
PABPCP5
chr8:101786345
PABPCP5
chr8:101786354
PABPCP5
chr8:101785791
PABPCP5
chr8:101796907
PABPCP5
chr8:101793817
PABPCP5
chr8:101791093
PABPCP5
chr8:101785784
PABPCP5
chr8:101796950
PABPCP5
chr8:101785785
PABPCP5
chr8:101796949
PABPCP5
chr8:101785771
PABPCP5
chr8:101788073
PABPCP5
chr8:101788079
PABPCP5
chr8:101790568
PABPCP5
chr8:101790574
PABPCP5
chr8:101791118
PABPCP5
chr8:101794062
PABPCP5
chr8:101794545
PABPCP5
chr8:101784321
PABPCP5
chr8:101784503
PABPCP5
chr8:101784599
PABPCP5
chr8:101784600
PABPCP5
chr8:101784606
PABPCP5
chr8:101803472
PABPCP5
chr14:22864695
PABPN1
chr14:22865013
PABPN1
chr14:22865182
PABPN1
chr22:41595729
PACSIN2
chr17:2532980
PAFAH1B1
chr17:2535168
PAFAH1B1
chr17:2535473
PAFAH1B1
chr17:2488238
PAFAH1B1
chr19:47496219
PAFAH1B3
chr5:43591725
PAIP1
chr5:138727405
PAIP2
chr11:76742248
PAK1
chr15:38300437
PAK6
chr16:23542873
PALB2
chr9:111972128 PALM2AKAP2
chr9:111972301 PALM2AKAP2
chr9:111974552 PALM2AKAP2
chr5:102370513
PAM
chr5:102337967
PAM
chr5:102366690
PAM
chr12:55004346
PAN2
chr12:55013030
PAN2
chr12:54999230
PAN2
chr13:27752636
PAN3
chr13:27766698
PAN3
chr13:27766862
PAN3
chr20:3845690
PANK2
chr20:3845697
PANK2
chr11:93552679
PANX1
chr5:79017379
PAPD4
chr5:78944653
PAPD4
chr14:96073110
PAPOLA
chr14:96056178
PAPOLA
chr14:96064092
PAPOLA
chr6:52378422
PAQR8
chr6:52377411
PAQR8
chr10:34666260
PARD3
chr3:185085358
PARL
chr16:14605575
PARN
chr16:14448285
PARN
chr8:145131195
PARP10
chr7:139403215
PARP12
chr7:139372585
PARP12
chr3:123921923
PARP14
chr3:123901737
PARP14
chr3:123932316
PARP14
chr3:123818607
PARP15
chr14:19893777
PARP2
chr14:19890338
PARP2
chr14:19895707
PARP2
chr14:19895519
PARP2
chr14:19895117
PARP2

coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
coding_exon
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon

ENST00000318607:StoN;ENST00000347137:StoN;
ENST00000318607:StoI;ENST00000347137:StoI;
ENST00000318607:StoC;ENST00000347137:StoC;
ENST00000318607:Sto*;ENST00000347137:Sto*;
ENST00000318607:RtoL;ENST00000347137:RtoL;
ENST00000318607:RtoK;ENST00000347137:RtoK;
ENST00000318607:RtoH;ENST00000347137:RtoH;
ENST00000318607:QtoL;ENST00000347137:QtoL;
ENST00000318607:PtoT;ENST00000347137:PtoT;
ENST00000318607:PtoR;ENST00000347137:PtoR;
ENST00000318607:LtoP;ENST00000347137:LtoP;
ENST00000318607:KtoT;ENST00000347137:KtoT;
ENST00000318607:KtoN;ENST00000347137:KtoN;
ENST00000318607:KtoE;ENST00000347137:KtoE;
ENST00000318607:ItoV;ENST00000347137:ItoV;
ENST00000318607:FtoL;ENST00000347137:FtoL;
ENST00000318607:EtoV;ENST00000347137:EtoV;
ENST00000318607:EtoQ;ENST00000347137:EtoQ;
ENST00000318607:EtoK;ENST00000347137:EtoK;
ENST00000318607:EtoG;ENST00000347137:EtoG;
ENST00000318607:EtoD;ENST00000347137:EtoD;
ENST00000318607:EtoD;ENST00000347137:EtoD;
ENST00000318607:DtoH;ENST00000347137:DtoH;
ENST00000318607:DtoG;ENST00000347137:DtoG;
ENST00000318607:DtoE;ENST00000347137:DtoE;
ENST00000318607:CtoS;ENST00000347137:CtoS;
ENST00000318607:AtoV;ENST00000347137:AtoV;
ENST00000318607:AtoT;ENST00000347137:AtoT;
ENST00000318607:AtoP;ENST00000347137:AtoP;
ENST00000318607:AtoG;ENST00000347137:AtoG;

ENST00000262890:TtoA;

ENST00000278568:FtoL;ENST00000356341:FtoL;
ENST00000261584:LtoP;

ENST00000304400:VtoG;ENST00000345721:VtoG;ENST00000346918:VtoG;ENST00

ENST00000257931:StoG;ENST00000379495:StoG;ENST00000425394:StoG;ENST000
ENST00000257931:LtoP;ENST00000379495:LtoP;ENST00000425394:LtoP;ENST0000

ENST00000316562:LtoR;ENST00000361370:LtoR;ENST00000399552:LtoR;ENST000
ENST00000227638:VtoA;ENST00000436171:VtoA;

ENST00000216277:StoP;
ENST00000216277:QtoH;
ENST00000216277:ItoK;
ENST00000361841:StoP;ENST00000442253:StoP;
ENST00000361841:AtoS;ENST00000442253:AtoS;
ENST00000340077:StoG;ENST00000346874:StoG;ENST00000374788:StoG;ENST000
ENST00000341484:YtoN;ENST00000420015:YtoN;ENST00000437198:YtoN;
ENST00000341484:KtoE;ENST00000420015:KtoE;ENST00000437198:KtoE;
ENST00000263549:PtoT;
ENST00000263549:GtoE;
ENST00000310276:KtoQ;ENST00000310290:KtoQ;ENST00000398157:KtoQ;ENST00

ENST00000250416:TtoR;ENST00000429687:TtoR;ENST00000446919:TtoR;
ENST00000250416:NtoD;ENST00000429687:NtoD;
ENST00000250416:NtoD;ENST00000429687:NtoD;
ENST00000250416:LtoR;ENST00000429687:LtoR;
ENST00000250416:LtoQ;ENST00000429687:LtoQ;ENST00000446919:LtoQ;

102

+
+
+

+
+
+
+

+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+

GtoA
GtoT
AtoT
CtoG
GtoT
GtoA
GtoA
AtoT
CtoA
CtoG
TtoC
AtoC
GtoT
AtoG
AtoG
TtoC
AtoT
GtoC
GtoA
AtoG
GtoT
GtoT
GtoC
AtoG
TtoG
TtoA
CtoT
GtoA
GtoC
CtoG
AtoT
AtoG
AtoC
TtoC
AtoG
TtoC
AtoG
AtoG
TtoC
TtoC
AtoG
CtoA
GtoA
GtoC
AtoC
TtoC
TtoC
TtoC
TtoA
AtoG
AtoG
AtoG
AtoG
TtoA
AtoG
TtoC
TtoC
TtoC
TtoC
CtoA
AtoG
TtoG
CtoA
AtoG
AtoG
TtoC
GtoT
TtoC
TtoC
TtoC
TtoG
AtoG
TtoC
AtoG
AtoG
TtoC
AtoC
TtoA
TtoC
GtoT
AtoG
TtoG
TtoA
AtoG
AtoG
CtoA
GtoA
AtoC
TtoC
TtoC
TtoC
CtoG
AtoG
AtoG
TtoG
TtoA

0.1111
0.1
0.1071
0.1
0.1333
0.1415
0.1
0.1148
0.1
0.1538
0.1111
0.1351
0.1
0.1053
0.1667
0.1176
0.1356
0.1136
0.125
0.1
0.1765
0.1053
0.2
0.1
0.2
0.1176
0.1
0.1071
0.1
0.1
0.1176
0.1
0.1061
0.125
0.1042
0.125
0.11
0.1064
0.1429
0.1013
0.1
0.1
0.1
0.1
0.1143
0.1034
0.1
0.1429
0.1
0.1
0.1429
0.12
0.1
0.1
0.1
0.1429
0.1
0.1
0.1176
0.125
0.1
0.1429
0.1
0.1
0.1
0.1
0.1667
0.1
0.1
0.1364
0.1111
0.1
0.1
0.1053
0.1
0.1
0.1026
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.125
0.1
0.1
0.1765
0.1
0.1
0.1111
0.1053

0.1667
0.1429
0.12
0.1818
0.1429
0.1852
0.2667
0.1311
0.2381
0.2381
0.2258
0.1429
0.1389
0.2188
0.1667
0.125
0.4
0.175
0.1429
0.1111
0.1818
0.1176
0.4667
0.125
0.2727
0.2
0.3636
0.4179
0.25
0.4203
0.1351
0.1507
0.2857
0.1724
0.1556
0.2381
0.1852
0.125
0.25
0.1263
0.1111
0.125
0.3889
0.1538
0.1964
0.1429
0.1429
0.15
0.1
0.1304
0.2308
0.1333
0.1
0.2143
0.2
0.2
0.1
0.1
0.2353
0.1538
0.1333
0.1818
0.1
0.1429
0.1667
0.1
0.1667
0.1
0.1
0.1579
0.2
0.125
0.1
0.1765
0.1
0.125
0.1818
0.1389
0.1818
0.125
0.1
0.1
0.1
0.1053
0.1053
0.1176
0.2
0.1333
0.1429
0.1333
0.125
0.1818
0.1176
0.1176
0.2258
0.1333

3
7
7
4
7
5
2
11
12
11
10
9
11
14
3
13
9
6
3
4
7
5
5
3
6
7
3
19
3
21
7
9
12
7
2
11
6
4
6
7
7
9
15
2
5
14
6
4
2
4
3
8
3
6
3
2
3
2
6
3
5
4
2
2
4
2
3
2
2
2
11
4
4
5
3
12
9
6
4
2
3
2
3
3
2
2
3
7
3
5
6
5
4
7
4
4

2
4
2
2
2
3
2
3
11
3
6
2
4
8
2
2
3
3
2
2
2
2
4
3
2
4
3
16
3
17
2
3
9
5
2
2
2
2
3
2
3
3
8
2
3
5
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
3
2
4
2
3
5
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
3
2
2

[12,27]
[14,38]
[25,30]
[10,11]
[45,77]
[28,106]
[10,16]
[63,117]
[28,105]
[22,79]
[13,37]
[39,56]
[36,62]
[13,39]
[12,12]
[16,18]
[16,64]
[40,57]
[14,17]
[10,10]
[12,17]
[17,19]
[10,15]
[10,24]
[10,11]
[12,20]
[10,16]
[14,101]
[10,12]
[10,101]
[17,39]
[51,116]
[51,160]
[29,43]
[47,49]
[21,24]
[27,100]
[35,48]
[12,22]
[81,98]
[10,38]
[16,29]
[14,31]
[10,13]
[32,56]
[15,29]
[10,14]
[14,20]
[10,10]
[10,23]
[13,14]
[15,25]
[10,10]
[10,14]
[10,30]
[10,15]
[10,10]
[10,10]
[18,18]
[13,16]
[10,19]
[11,21]
[10,10]
[10,14]
[10,12]
[10,10]
[12,12]
[10,10]
[10,10]
[19,22]
[10,18]
[10,25]
[10,10]
[17,32]
[10,10]
[10,34]
[38,57]
[16,37]
[10,11]
[10,16]
[10,10]
[10,10]
[10,10]
[10,19]
[10,19]
[10,17]
[10,10]
[20,30]
[14,16]
[10,15]
[10,17]
[11,17]
[10,17]
[10,19]
[18,32]
[15,19]

TableS10

chr14:19892155
chr15:70336789
chr5:50159615
chr3:123757164
chr3:123737766
chr3:123757108
chr3:123761245
chr1:54995338
chr11:59183492
chr11:59183303
chr11:59183334
chr11:59183430
chr11:59171846
chr12:78514452
chr9:37023984
chr9:36823550
chr9:36823819
chr9:36823882
chr7:154398355
chr7:154385099
chr7:105700327
chr9:127765122
chr9:127769351
chr10:72313333
chr5:134324233
chr12:52159723
chr12:52159874
chr12:52159885
chr12:52160860
chr3:137531642
chr3:137539193
chr11:82557470
chr11:82573803
chr4:745182
chr4:717578
chr4:749931
chr4:750196
chr4:750888
chr4:751258
chr10:93030360
chr13:112887847
chr13:112880443
chr20:44003239
chr8:17867874
chr8:17893466
chr8:17893487
chr8:17893467
chr8:17837417
chr6:150165052
chr20:5048591
chr21:46655532
chr21:46674382
chr14:70515114
chr14:70646596
chr11:65141554
chr11:65154620
chr11:65154477
chr11:116594456
chr12:95229072
chr7:98830257
chr10:105150195
chr6:170728573
chr10:112648280
chr10:112648281
chr5:368077
chr5:489022
chr5:489290
chr5:490017
chr5:490984
chr15:63197551
chr9:124622141
chr2:100559287
chr2:100551896
chr2:100559362
chr2:100554512
chr2:100552521
chr2:100549417
chr2:100552520
chr2:100552577
chr2:100554670
chr2:100559288
chr2:100559378
chr2:100559401
chr11:760217
chr3:57518140
chr19:10441251
chr8:66793024
chr8:66793332
chr8:66793334
chr15:83482585
chr11:34962769
chr11:34944833
chr2:10860095
chr2:10846497
chr10:96987579
chr16:2589019

PARP2
PARP6
PARP8
PARP9
PARP9
PARP9
PARP9
PARS2
PATL1
PATL1
PATL1
PATL1
PATL1
PAWR
PAX5
PAX5
PAX5
PAX5
PAXIP1
PAXIP1
PBEF1
PBX3
PBX3
PCBD1
PCBD2
PCBP2
PCBP2
PCBP2
PCBP2
PCCB
PCCB
PCF11
PCF11
PCGF3
PCGF3
PCGF3
PCGF3
PCGF3
PCGF3
PCGF5
PCID2
PCID2
PCIF1
PCM1
PCM1
PCM1
PCM1
PCM1
PCMT1
PCNA
PCNT
PCNT
PCNX
PCNX
PCNXL3
PCNXL3
PCNXL3
PCSK7
PCTK2
PDAP1
PDCD11
PDCD2
PDCD4
PDCD4
PDCD6
PDCD6
PDCD6
PDCD6
PDCD6
PDCD7
PDCL
PDCL3
PDCL3
PDCL3
PDCL3
PDCL3
PDCL3
PDCL3
PDCL3
PDCL3
PDCL3
PDCL3
PDCL3
PDDC1
PDE12
PDE4A
PDE7A
PDE7A
PDE7A
PDE8A
PDHX
PDHX
PDIA6
PDIA6
PDLIM1
PDPK1

coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
mixed
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
mixed
UTR3
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
UTR5
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
coding_exon
UTR3
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3

ENST00000260376:LtoP;ENST00000287196:LtoP;ENST00000336471:LtoP;ENST0000
ENST00000360356:ItoV;ENST00000452457:ItoV;ENST00000462315:ItoV;ENST0000

ENST00000300146:RtoC;ENST00000428532:RtoC;
ENST00000300146:Qto*;ENST00000428532:Qto*;

ENST00000323199:PtoR;ENST00000397192:PtoR;ENST00000404141:PtoR;ENST000
ENST00000222553:HtoR;ENST00000354289:HtoR;ENST00000393617:HtoR;
ENST00000373483:LtoP;ENST00000373487:LtoP;ENST00000373489:LtoP;ENST0000

ENST00000254908:LtoP;ENST00000398833:LtoP;

ENST00000362003:LtoP;ENST00000470161:LtoP;
ENST00000362003:FtoV;ENST00000470161:FtoV;

ENST00000246505:WtoR;ENST00000246506:WtoR;ENST00000337344:WtoR;ENST0
ENST00000372409:CtoF;ENST00000443130:CtoF;
ENST00000325083:QtoR;ENST00000327578:QtoR;ENST00000412583:QtoR;
ENST00000325083:GtoD;ENST00000327578:GtoD;ENST00000412583:GtoD;
ENST00000325083:EtoA;ENST00000327578:EtoA;ENST00000412583:EtoA;

ENST00000359568:VtoA;
ENST00000359568:EtoG;

ENST00000355703:RtoT;
ENST00000355703:LtoP;ENST00000439247:LtoP;

ENST00000369797:AtoS;

ENST00000264254:TtoI;
ENST00000264254:RtoC;
ENST00000264254:KtoR;
ENST00000264254:HtoN;
ENST00000264254:Gto*;

ENST00000311180:QtoE;ENST00000487257:QtoE;

ENST00000227868:VtoG;ENST00000430469:VtoG;ENST00000448838:VtoG;
ENST00000227868:TtoP;ENST00000448838:TtoP;
ENST00000272227:VtoL;ENST00000381611:VtoL;ENST00000404371:VtoL;ENST000
ENST00000272227:VtoG;ENST00000381611:VtoG;ENST00000404371:VtoG;ENST00

103

+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+

+
+
+
+
+
+
+

+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+

+
+

+
+
+

GtoA
TtoC
TtoA
AtoG
AtoG
AtoG
AtoT
GtoT
CtoT
CtoT
TtoC
GtoA
CtoT
AtoG
AtoC
GtoA
TtoA
TtoA
CtoG
AtoG
AtoG
TtoC
AtoG
AtoG
TtoC
TtoG
TtoA
TtoA
GtoA
TtoC
AtoG
TtoC
TtoC
TtoC
TtoG
TtoG
CtoT
CtoT
TtoC
TtoC
TtoC
TtoC
GtoT
AtoG
GtoA
AtoC
TtoA
TtoC
AtoT
AtoT
TtoC
AtoG
TtoC
AtoC
GtoC
TtoC
TtoC
TtoC
GtoA
CtoT
GtoT
AtoG
TtoA
AtoG
AtoG
GtoC
AtoG
TtoA
AtoT
TtoG
AtoG
CtoT
CtoT
AtoG
CtoA
GtoT
AtoG
CtoT
CtoT
CtoT
AtoG
CtoT
TtoG
TtoC
CtoG
TtoC
AtoG
GtoA
GtoA
CtoA
TtoG
AtoC
GtoT
TtoG
TtoC
TtoC

0.1176
0.125
0.1
0.1176
0.1
0.1
0.1
0.1
0.1538
0.1667
0.1
0.1538
0.1
0.1
0.1111
0.1
0.1
0.1667
0.1
0.1667
0.1111
0.1333
0.1538
0.1
0.1
0.2308
0.1034
0.1
0.1111
0.1
0.1
0.1
0.1333
0.1111
0.1667
0.1
0.1
0.1
0.1
0.1429
0.1111
0.1053
0.1
0.1
0.1
0.1
0.1176
0.1
0.1053
0.1111
0.1
0.1
0.1
0.1
0.1111
0.1111
0.1111
0.1
0.1
0.1154
0.1
0.1071
0.1053
0.1053
0.1
0.1
0.1333
0.1
0.1538
0.1
0.1
0.1176
0.1333
0.1154
0.1111
0.1429
0.1111
0.25
0.2
0.1
0.1212
0.1111
0.1
0.1
0.1
0.1
0.1111
0.1053
0.1111
0.1
0.1538
0.1538
0.1067
0.1062
0.4489
0.1

0.125
0.1429
0.1333
0.2308
0.1538
0.1
0.1111
0.1
0.5333
0.8
0.1333
0.2727
0.1071
0.2
0.1176
0.1667
0.1
0.2
0.1667
0.1765
0.2
0.1667
0.1667
0.125
0.1818
0.2368
0.2105
0.2
0.1364
0.1905
0.1
0.1
0.1429
0.1176
0.2
0.1
0.1
0.4286
0.1818
0.1875
0.1429
0.1364
0.1
0.1154
0.1579
0.1667
0.2083
0.1053
0.125
0.1111
0.1
0.1
0.1538
0.1111
0.15
0.125
0.125
0.2353
0.1
0.25
0.1818
0.1176
0.1765
0.125
0.1
0.1333
0.2
0.1667
0.2
0.1176
0.1111
0.5882
0.175
0.125
0.3462
0.4286
0.3077
0.4286
0.5789
0.2083
0.6316
0.1212
0.2143
0.1429
0.1
0.1
0.2222
0.1111
0.125
0.125
0.2
0.24
0.1809
0.1458
0.529
0.1

3
6
6
11
2
2
2
2
3
4
4
2
4
3
4
3
3
2
2
2
9
5
2
7
2
2
7
6
2
7
2
3
2
4
3
3
2
2
4
2
6
5
2
3
9
11
10
4
4
5
2
3
2
3
2
6
3
3
2
4
2
8
10
5
2
2
4
4
2
5
2
10
7
2
8
8
6
3
3
6
11
2
7
3
2
4
10
3
3
3
2
5
8
7
2
3

2
2
3
5
2
2
2
2
3
2
2
2
2
2
2
3
2
2
2
2
7
2
2
4
2
2
5
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
6
5
5
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
5
2
2
2
3
2
2
2
2
5
2
2
5
6
2
2
2
3
5
2
4
2
2
2
2
2
2
2
2
5
4
4
2
2

[16,17]
[15,16]
[10,15]
[13,19]
[10,13]
[10,20]
[10,10]
[10,10]
[11,15]
[10,12]
[15,40]
[11,13]
[28,30]
[10,11]
[18,34]
[10,19]
[10,10]
[10,12]
[10,12]
[12,17]
[10,22]
[12,15]
[12,13]
[10,20]
[10,11]
[13,40]
[10,30]
[10,10]
[18,22]
[20,21]
[10,10]
[10,10]
[14,15]
[17,18]
[10,12]
[10,10]
[10,10]
[10,14]
[10,11]
[14,16]
[14,29]
[19,22]
[10,10]
[10,26]
[10,37]
[12,40]
[12,29]
[10,19]
[16,19]
[18,45]
[10,10]
[10,20]
[10,13]
[10,10]
[18,20]
[16,18]
[16,18]
[17,31]
[10,10]
[20,51]
[11,20]
[17,28]
[17,45]
[19,24]
[10,10]
[10,15]
[15,21]
[10,18]
[10,13]
[10,17]
[10,19]
[17,48]
[15,40]
[24,26]
[15,26]
[12,19]
[13,45]
[12,14]
[19,20]
[20,64]
[19,46]
[33,54]
[13,48]
[10,14]
[10,10]
[10,10]
[18,27]
[18,19]
[16,18]
[10,16]
[10,13]
[10,25]
[18,94]
[48,139]
[483,499]
[10,10]

TableS10

chr16:68751371
chr16:68751935
chr16:68752188
chr20:29996986
chr20:29996992
chr4:39527662
chr4:39580434
chr4:39515894
chr4:39582177
chr4:39501007
chr4:39502887
chr10:27052851
chr21:44005989
chr21:44005999
chr10:119033429
chr12:117067768
chr2:216612298
chr2:64181136
chr2:64174340
chr5:52132305
chr17:17353516
chr17:7984943
chr4:152820417
chr15:88027517
chr2:61129178
chr1:10612870
chr1:158514053
chr1:158514895
chr22:16950857
chr22:16952021
chr22:16952235
chr22:16953508
chr22:16953514
chr22:16953774
chr12:7253657
chr6:137232763
chr6:137232828
chr17:8109640
chr17:8098256
chr17:8109069
chr17:8097989
chr1:159337058
chr12:51979496
chr10:6308237
chr10:6315310
chr10:6317003
chr10:6317403
chr3:48530153
chr21:44571677
chr21:44571683
chr12:46814320
chr12:46825818
chr10:3168993
chr10:3168971
chr17:4789784
chr11:3801714
chr11:3803510
chr1:10395757
chr1:10402646
chr19:17489563
chr4:37517868
chr16:2203740
chr19:18337948
chr19:18337979
chr19:18340609
chr19:18340869
chr19:18340916
chr4:129411749
chr17:73911735
chr17:73911611
chr1:28679556
chr1:28665553
chr1:28697361
chr5:125988538
chr17:44845585
chr17:44845601
chr17:44845547
chr17:44845581
chr17:44847228
chr1:33561980
chr3:171293617
chr6:33490098
chr6:33488541
chr6:33492045
chr6:169846442
chr5:133942351
chr4:130002450
chr4:130002324
chr9:122671928
chr9:122676671
chr9:122671717
chr9:122657824
chr20:33922362
chr20:34000070
chr20:34000697
chr8:133875902

PDPR
PDPR
PDPR
PDRG1
PDRG1
PDS5A
PDS5A
PDS5A
PDS5A
PDS5A
PDS5A
PDSS1
PDXK
PDXK
PDZD8
PEBP1
PECR
PELI1
PELI1
PELO
PEMT
PER1
PET112L
PEX11A
PEX13
PEX14
PEX19
PEX19
PEX26
PEX26
PEX26
PEX26
PEX26
PEX26
PEX5
PEX7
PEX7
PFAS
PFAS
PFAS
PFAS
PFDN2
PFDN5
PFKFB3
PFKFB3
PFKFB3
PFKFB3
PFKFB4
PFKL
PFKL
PFKM
PFKM
PFKP
PFKP
PFN1
PGAP2
PGAP2
PGD
PGD
PGLS
PGM2
PGP
PGPEP1
PGPEP1
PGPEP1
PGPEP1
PGPEP1
PGRMC2
PGS1
PGS1
PHACTR4
PHACTR4
PHACTR4
PHAX
PHB
PHB
PHB
PHB
PHB
PHC2
PHC3
PHF1
PHF1
PHF1
PHF10
PHF15
PHF17
PHF17
PHF19
PHF19
PHF19
PHF19
PHF20
PHF20
PHF20
PHF20L1

UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
mixed
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
mixed
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
UTR3
UTR3
coding_exon
mixed
UTR3
coding_exon
mixed
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
mixed
UTR3
UTR3
coding_exon

ENST00000303538:LtoQ;ENST00000412404:LtoQ;
ENST00000303538:HtoR;ENST00000412404:HtoR;

ENST00000358912:AtoV;
ENST00000274311:NtoT;ENST00000381463:NtoT;
ENST00000255389:MtoV;ENST00000343219:MtoV;ENST00000395781:MtoV;ENST0
ENST00000263985:Qto*;

ENST00000266563:StoP;ENST00000266564:StoP;ENST00000396637:StoP;ENST000
ENST00000318471:WtoR;
ENST00000318471:RtoS;
ENST00000314666:TtoP;
ENST00000314666:FtoV;
ENST00000314666:EtoD;

ENST00000340802:HtoR;ENST00000359794:HtoR;ENST00000395233:HtoR;

ENST00000278243:StoI;ENST00000300730:StoI;ENST00000396986:StoI;ENST00000
ENST00000270776:TtoP;

ENST00000381967:FtoI;
ENST00000333503:LtoH;

ENST00000262764:WtoR;ENST00000329897:WtoR;ENST00000335081:WtoR;
ENST00000262764:NtoK;ENST00000329897:NtoK;ENST00000335081:NtoK;
ENST00000373836:LtoP;ENST00000373837:LtoP;ENST00000373839:LtoP;

ENST00000300408:LtoP;ENST00000393345:LtoP;ENST00000434917:LtoP;
ENST00000300408:ItoV;ENST00000393345:ItoV;ENST00000434917:ItoV;

ENST00000374512:WtoR;ENST00000374516:WtoR;

ENST00000226319:EtoK;ENST00000413543:EtoK;ENST00000452328:EtoK;
ENST00000226319:CtoR;ENST00000413543:CtoR;ENST00000452328:CtoR;
ENST00000312189:StoP;
ENST00000312189:LtoP;ENST00000373896:LtoP;

ENST00000315808:WtoR;ENST00000337920:WtoR;ENST00000361997:WtoR;ENST0

104

+
+
+

+
+
+

+
+

+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+

+
+
+
+
+
+

+
+
+
+
+
+

+
+
+
+
+

+
+
+
+
+
+

+
+
+

+
+
+

+
+
+
+

CtoT
AtoG
GtoT
TtoG
TtoG
TtoA
AtoG
AtoG
TtoC
TtoG
TtoC
TtoC
TtoC
AtoG
AtoG
AtoG
AtoC
CtoT
TtoC
AtoC
AtoG
TtoG
CtoT
TtoA
TtoC
GtoC
AtoG
GtoA
AtoC
AtoG
AtoC
AtoG
TtoA
AtoG
TtoC
TtoC
GtoT
AtoC
TtoG
AtoC
AtoG
AtoG
GtoA
AtoG
TtoC
TtoC
TtoC
CtoG
TtoC
GtoA
AtoG
TtoC
AtoC
TtoA
CtoA
GtoT
GtoT
AtoC
TtoG
AtoC
TtoA
TtoA
AtoG
AtoC
TtoC
GtoA
TtoG
GtoT
TtoC
TtoA
TtoC
TtoC
AtoG
TtoC
TtoC
AtoG
TtoC
CtoG
GtoT
GtoT
TtoA
TtoC
TtoC
TtoC
TtoA
AtoC
GtoA
TtoC
TtoC
TtoC
AtoG
TtoC
TtoC
TtoA
TtoC
TtoC

0.1
0.1
0.1667
0.1176
0.1379
0.1818
0.1053
0.1111
0.1053
0.1
0.1818
0.1
0.1
0.1
0.1
0.1429
0.1
0.1429
0.1
0.1
0.125
0.1
0.1429
0.1
0.1
0.1
0.125
0.1
0.1
0.1053
0.1111
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1176
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1333
0.1053
0.3
0.1
0.1
0.1667
0.1071
0.987
0.1818
0.1538
0.1042
0.1053
0.1212
0.1176
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1154
0.1
0.1
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1429
0.1067
0.1429
0.1667
0.1
0.1
0.1
0.1

0.1538
0.1176
0.2414
0.1538
0.25
0.1818
0.1667
0.1333
0.2
0.1579
0.3
0.1
0.1
0.125
0.1
0.3
0.1053
0.3
0.1429
0.3125
0.1429
0.1
0.25
0.1
0.2143
0.1
0.1667
0.1818
0.1538
0.1176
0.1212
0.1538
0.1538
0.2
0.1176
0.1667
0.1
0.2
0.15
0.1429
0.1
0.3333
0.1026
0.1
0.1364
0.2
0.125
0.1538
0.2545
0.7
0.1538
0.2083
0.1818
0.381
0.9995
0.1818
0.4
0.1299
0.125
0.1731
0.1176
0.2222
0.1333
0.125
0.1053
0.1
0.1154
0.1
0.1
0.1
0.15
0.1
0.2353
0.1
0.3
0.1176
0.1053
0.2
0.1667
0.1818
0.1
0.1111
0.1111
0.1875
0.1
0.1176
0.1538
0.1
0.2105
0.1356
0.1818
0.1667
0.1333
0.1111
0.2727
0.1333

4
3
6
4
7
8
4
3
6
4
9
2
2
4
2
2
3
5
3
5
3
2
2
2
2
2
4
2
6
4
4
6
4
3
3
2
2
5
7
4
2
11
7
2
6
2
3
2
14
6
4
11
4
6
12
2
2
4
2
5
4
2
8
2
3
2
2
2
2
2
6
3
10
2
8
5
6
6
5
2
2
3
3
3
2
3
2
3
4
9
3
2
3
3
10
3

4
2
3
3
3
2
2
2
3
4
2
2
2
3
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
9
2
2
4
2
2
2
9
6
2
5
2
6
12
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
6
2
6
2
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
4
2

[10,24]
[10,17]
[18,29]
[13,34]
[14,34]
[11,12]
[12,19]
[15,18]
[10,38]
[10,19]
[10,11]
[10,11]
[10,10]
[10,16]
[10,10]
[10,14]
[10,19]
[10,14]
[10,14]
[10,16]
[14,16]
[10,20]
[12,14]
[10,10]
[10,14]
[10,10]
[12,16]
[10,11]
[10,13]
[17,19]
[27,33]
[10,13]
[10,13]
[10,10]
[18,18]
[10,12]
[10,10]
[10,20]
[17,20]
[14,19]
[10,20]
[10,26]
[10,39]
[10,10]
[10,22]
[10,10]
[16,19]
[13,15]
[19,81]
[10,23]
[13,20]
[13,37]
[11,13]
[28,56]
[733,3188]
[11,11]
[10,13]
[77,96]
[89,115]
[52,66]
[17,18]
[10,16]
[10,17]
[10,16]
[10,19]
[10,10]
[20,26]
[10,10]
[10,10]
[10,10]
[10,20]
[10,10]
[17,32]
[10,10]
[10,19]
[17,26]
[10,19]
[10,16]
[12,16]
[10,11]
[10,10]
[10,18]
[10,18]
[10,16]
[10,10]
[17,17]
[10,13]
[10,20]
[14,19]
[59,75]
[11,14]
[12,12]
[10,15]
[10,10]
[10,17]
[10,16]

TableS10

chr11:45947950
chr11:45910861
chr11:45911459
chr6:64480005
chr6:64459669
chr6:64459745
chr6:64452497
chr6:64480006
chr6:79707330
chr6:79768393
chr6:79770294
chr9:138863384
chr9:138863463
chr11:598595
chr11:599652
chr7:77369034
chr4:24888547
chr22:19445639
chr1:149555149
chr1:149565402
chr15:66267027
chr15:66253125
chr15:66253251
chr18:42663735
chr18:42724626
chr1:144289547
chr11:85347686
chr22:36801064
chr15:62899222
chr15:62899235
chr15:62897198
chr4:491339
chr14:67136571
chr14:67126614
chr14:67129153
chr14:67136521
chr14:67126071
chr14:67126403
chr14:67126431
chr17:16170116
chr18:57864117
chr17:23904783
chr10:98370163
chr10:98370217
chr1:202679305
chr1:202691743
chr18:37901393
chr18:37849439
chr18:37791590
chr18:37877697
chr5:67629170
chr5:67632835
chr5:67632909
chr19:18141408
chr1:46294126
chr1:46279215
chr1:46281458
chr3:131882583
chr3:131881018
chr17:8734072
chr17:8722997
chr17:8665945
chr17:8665936
chr6:37249811
chr6:37249967
chr6:37250314
chr6:37250504
chr6:37250505
chr22:48743697
chr22:48743698
chr12:56281857
chr1:149481621
chr1:149437985
chr19:3581290
chr19:3581485
chr19:3593910
chr10:22863909
chr17:34209055
chr17:1403186
chr17:1369181
chr22:26578453
chr11:67021280
chr11:67021279
chr10:3177869
chr10:3198510
chr10:3170113
chr5:108699624
chr16:2078887
chr8:110608245
chr15:70278424
chr15:70278425
chr15:70278426
chr16:2961341
chr16:2962666
chr3:120831052
chr22:36841566

PHF21A
PHF21A
PHF21A
PHF3
PHF3
PHF3
PHF3
PHF3
PHIP
PHIP
PHIP
PHPT1
PHPT1
PHRF1
PHRF1
PHTF2
PI4K2B
PI4KA
PI4KB
PI4KB
PIAS1
PIAS1
PIAS1
PIAS2
PIAS2
PIAS3
PICALM
PICK1
PIF1
PIF1
PIF1
PIGG
PIGH
PIGH
PIGH
PIGH
PIGH
PIGH
PIGH
PIGL
PIGN
PIGS
PIK3AP1
PIK3AP1
PIK3C2B
PIK3C2B
PIK3C3
PIK3C3
PIK3C3
PIK3C3
PIK3R1
PIK3R1
PIK3R1
PIK3R2
PIK3R3
PIK3R3
PIK3R3
PIK3R4
PIK3R4
PIK3R5
PIK3R5
PIK3R6
PIK3R6
PIM1
PIM1
PIM1
PIM1
PIM1
PIM3
PIM3
PIP4K2C
PIP5K1A
PIP5K1A
PIP5K1C
PIP5K1C
PIP5K1C
PIP5K2A
PIP5K2B
PITPNA
PITPNA
PITPNB
PITPNM1
PITPNM1
PITRM1
PITRM1
PITRM1
PJA2
PKD1
PKHD1L1
PKM2
PKM2
PKM2
PKMYT1
PKMYT1
PLA1A
PLA2G6

coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
UTR5
UTR5
coding_exon
coding_exon
coding_exon
UTR3
mixed
mixed
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR5
mixed
mixed
mixed
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
mixed

ENST00000257821:LtoI;ENST00000323180:LtoI;ENST00000418153:LtoI;

ENST00000262043:KtoR;ENST00000393387:KtoR;
ENST00000262043:GtoD;ENST00000393387:GtoD;
ENST00000262043:DtoE;ENST00000393387:DtoE;

ENST00000275034:EtoD;

ENST00000264555:StoP;ENST00000413872:StoP;ENST00000416188:StoP;
ENST00000264555:LtoP;ENST00000413872:LtoP;ENST00000416188:LtoP;

ENST00000249636:StoA;
ENST00000249636:LtoH;
ENST00000249636:KtoM;

ENST00000268043:TtoP;ENST00000333425:TtoP;
ENST00000268043:CtoW;ENST00000333425:CtoW;
ENST00000296306:MtoK;ENST00000310340:MtoK;ENST00000453061:MtoK;ENST0
ENST00000216452:RtoG;
ENST00000216452:ItoT;

ENST00000339364:VtoG;ENST00000371109:VtoG;ENST00000371110:VtoG;
ENST00000339364:LtoR;ENST00000371109:LtoR;ENST00000371110:LtoR;
ENST00000367187:YtoN;
ENST00000367187:TtoA;
ENST00000262039:VtoG;ENST00000398870:VtoG;
ENST00000262039:StoP;ENST00000398870:StoP;

ENST00000262741:EtoG;ENST00000340332:EtoG;ENST00000372006:EtoG;ENST000

ENST00000356763:VtoA;
ENST00000356763:EtoG;
ENST00000269300:WtoG;ENST00000444598:WtoG;ENST00000447110:WtoG;
ENST00000311434:VtoF;ENST00000434064:VtoF;
ENST00000311434:RtoL;ENST00000434064:RtoL;

ENST00000269554:VtoA;
ENST00000313486:VtoA;

ENST00000356404:EtoA;ENST00000436757:EtoA;

ENST00000378402:TtoA;ENST00000426474:TtoA;

105

+
+
+
+
+

+
+
+
+
+
+

+
+
+

+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+

CtoA
TtoC
AtoC
AtoG
GtoA
TtoA
TtoC
GtoA
GtoT
TtoC
AtoG
CtoG
TtoC
TtoC
TtoC
AtoG
CtoT
TtoG
AtoG
TtoG
TtoG
TtoA
AtoT
AtoG
AtoG
TtoC
AtoG
TtoG
AtoC
TtoG
AtoG
TtoA
CtoG
TtoC
AtoG
GtoA
TtoC
TtoA
GtoA
GtoA
AtoG
AtoT
TtoG
TtoG
TtoA
AtoG
TtoG
TtoC
AtoG
CtoT
AtoG
GtoA
AtoG
TtoG
AtoG
AtoG
TtoC
TtoC
AtoG
TtoG
AtoG
GtoT
GtoT
AtoC
AtoG
TtoC
TtoA
GtoT
TtoC
AtoG
AtoG
AtoG
TtoC
AtoC
TtoC
TtoG
TtoC
TtoC
TtoC
AtoT
AtoG
AtoC
GtoA
AtoG
TtoC
TtoC
TtoC
TtoC
AtoG
CtoA
CtoA
AtoG
CtoA
GtoA
GtoT
TtoC

0.1
0.1429
0.1364
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1
0.1667
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1429
0.1
0.1
0.1176
0.1765
0.1
0.1818
0.1333
0.1538
0.2727
0.1053
0.1
0.1579
0.1
0.1
0.12
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1429
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1176
0.125
0.1
0.1
0.1
0.1
0.1
0.1176
0.15
0.1667
0.1
0.2
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1034
0.1
0.1
0.1
0.1
0.1
0.1
0.2025
0.2576
0.1154
0.1
1
0.1034
0.1

0.1
0.2143
0.2222
0.1
0.1
0.1
0.1111
0.1818
0.1
0.1364
0.2727
0.2308
0.1538
0.1667
0.1
0.1
0.1
0.1333
0.1429
0.1
0.1053
0.1538
0.1
0.125
0.1667
0.1
0.2
0.1
0.1
0.1429
0.2
0.1111
0.7143
0.2
0.2
0.2727
0.1538
0.2143
0.1923
0.1111
0.1
0.1212
0.125
0.1
0.1
0.1
0.3077
0.1111
0.2
0.1
0.1
0.1176
0.3125
0.1
0.1538
0.1333
0.1333
0.1538
0.1
0.1
0.3333
0.16
0.2955
0.1
0.1667
0.1
0.3
0.2
0.2
0.2308
0.1667
0.5294
0.1429
0.1
0.2
0.1
0.1429
0.1818
0.2
0.1
0.1351
0.12
0.125
0.1
0.125
0.125
0.3333
0.125
0.1
1
0.9412
0.2885
0.1
1
0.2
0.1176

2
7
6
3
2
2
2
3
3
5
10
4
2
3
2
2
2
4
3
3
3
4
2
3
2
3
3
4
2
4
4
2
3
6
4
2
3
7
2
2
2
2
3
2
3
2
7
3
3
2
2
2
4
2
2
8
2
5
2
2
5
6
6
2
3
2
6
4
3
3
3
3
4
3
4
2
6
3
5
2
4
4
3
2
2
2
4
2
2
8
18
20
2
6
4
2

2
3
3
2
2
2
2
2
2
2
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
6
2
3
2
2
2
3
2
2
2
2
3
2
2
3
6
2
2
2
2
4
3
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
8
18
12
2
6
2
2

[10,10]
[11,14]
[18,33]
[10,10]
[10,10]
[10,10]
[10,18]
[10,11]
[10,20]
[15,22]
[10,19]
[13,18]
[10,13]
[10,12]
[10,10]
[10,10]
[10,10]
[10,15]
[20,21]
[10,10]
[10,19]
[10,13]
[10,10]
[10,16]
[10,12]
[10,10]
[10,14]
[10,10]
[10,10]
[14,21]
[10,17]
[10,10]
[10,14]
[15,15]
[10,13]
[11,11]
[13,19]
[10,14]
[19,26]
[10,18]
[10,10]
[25,33]
[16,31]
[10,10]
[10,10]
[10,10]
[10,16]
[10,18]
[10,12]
[10,10]
[10,10]
[10,17]
[12,16]
[10,10]
[10,13]
[10,15]
[10,15]
[13,18]
[10,20]
[10,10]
[12,17]
[16,40]
[20,44]
[10,10]
[10,12]
[10,10]
[10,16]
[10,17]
[10,20]
[12,21]
[10,12]
[10,17]
[10,14]
[20,30]
[10,10]
[10,10]
[10,15]
[10,11]
[10,20]
[10,10]
[27,37]
[10,25]
[16,29]
[10,10]
[16,20]
[16,20]
[11,20]
[16,40]
[10,10]
[10,84]
[11,137]
[17,52]
[10,10]
[10,18]
[10,29]
[10,17]

TableS10

chr4:84234882
chr4:84254887
chr15:38374498
chr15:38372436
chr15:38367645
chr3:17106607
chr8:145064465
chr8:145068731
chr8:145061375
chr8:38949459
chr8:38949583
chr8:38950528
chr2:131623833
chr19:44606867
chr1:148397845
chr4:129027333
chr4:155679745
chr4:155686459
chr3:147745103
chr3:48420928
chr12:93197392
chr12:93221740
chr18:55721739
chr1:154449469
chr15:72122587
chr15:72124731
chr16:8850554
chr9:138438021
chr9:138438024
chr7:102739765
chr2:218914554
chr2:218912844
chr2:218850400
chr2:218854968
chr14:38721857
chr8:28242716
chr8:28252871
chr11:812569
chr19:7513741
chr17:43377042
chr17:43381578
chr17:43381620
chr2:55726022
chr2:55747723
chr6:89850615
chr6:89847281
chr6:89847283
chr6:89847284
chr20:30288193
chr21:45508846
chr1:165084960
chr1:165090212
chr1:165090285
chr1:149668792
chr1:149669792
chr1:149644865
chr1:149643420
chr1:149643684
chr11:64821364
chr8:42348373
chr7:44128278
chr11:74017960
chr11:66875599
chr17:23698373
chr22:41309718
chr22:41310356
chr22:41310362
chr12:131719111
chr12:131728479
chr12:131728882
chr15:87671224
chr15:87663575
chr15:87662900
chr6:43689602
chr2:86122575
chr2:113033574
chr2:113021068
chr2:113023377
chr13:27138554
chr13:27138834
chr9:37476086
chr17:7356012
chr17:7356274
chr4:57567852
chr4:57555756
chr2:128321840
chr2:128321844
chr2:128321846
chr19:1037628
chr19:1037629
chr22:36693703
chr11:830202
chr10:79443427
chr10:79432040
chr10:79405482
chr16:22253170

PLAC8
PLAC8
PLCB2
PLCB2
PLCB2
PLCL2
PLEC1
PLEC1
PLEC1
PLEKHA2
PLEKHA2
PLEKHA2
PLEKHB2
PLEKHG2
PLEKHO1
PLK4
PLRG1
PLRG1
PLSCR1
PLXNB1
PLXNC1
PLXNC1
PMAIP1
PMF1
PML
PML
PMM2
PMPCA
PMPCA
PMPCB
PNKD
PNKD
PNKD
PNKD
PNN
PNOC
PNOC
PNPLA2
PNPLA6
PNPO
PNPO
PNPO
PNPT1
PNPT1
PNRC1
PNRC1
PNRC1
PNRC1
POFUT1
POFUT2
POGK
POGK
POGK
POGZ
POGZ
POGZ
POGZ
POGZ
POLA2
POLB
POLD2
POLD3
POLD4
POLDIP2
POLDIP3
POLDIP3
POLDIP3
POLE
POLE
POLE
POLG
POLG
POLG
POLH
POLR1A
POLR1B
POLR1B
POLR1B
POLR1D
POLR1D
POLR1E
POLR2A
POLR2A
POLR2B
POLR2B
POLR2D
POLR2D
POLR2D
POLR2E
POLR2E
POLR2F
POLR2L
POLR3A
POLR3A
POLR3A
POLR3E

coding_exon
UTR5
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
mixed
coding_exon
coding_exon
UTR3
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR5
UTR5
UTR5
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR5
coding_exon
UTR3
mixed
UTR3
UTR3
UTR3
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
UTR3
coding_exon
coding_exon
UTR3
UTR3

ENST00000311507:RtoS;ENST00000411416:RtoS;ENST00000426923:RtoS;
ENST00000260402:StoP;ENST00000456256:StoP;
ENST00000260402:ItoN;ENST00000456256:ItoN;

ENST00000322810:StoA;ENST00000345136:StoA;ENST00000354589:StoA;ENST000
ENST00000322810:ItoL;ENST00000345136:ItoL;ENST00000354589:ItoL;ENST00000

ENST00000409794:LtoR;ENST00000425673:LtoR;ENST00000458508:LtoR;
ENST00000025469:EtoK;ENST00000369124:EtoK;
ENST00000270861:LtoR;
ENST00000302078:HtoQ;ENST00000393905:HtoQ;

ENST00000258526:VtoA;

ENST00000320139:CtoW;ENST00000368273:CtoW;ENST00000368276:CtoW;ENST0

ENST00000258362:VtoG;ENST00000273077:VtoG;ENST00000436005:VtoG;
ENST00000258362:TtoP;ENST00000273077:TtoP;ENST00000436005:TtoP;

ENST00000336615:YtoS;
ENST00000221249:PtoL;ENST00000414982:PtoL;ENST00000450331:PtoL;
ENST00000225573:FtoI;ENST00000434554:FtoI;

ENST00000336032:LtoP;

ENST00000367875:MtoV;ENST00000367876:MtoV;

ENST00000271715:VtoA;ENST00000361398:VtoA;ENST00000392723:VtoA;ENST00
ENST00000271715:StoP;ENST00000361398:StoP;ENST00000392723:StoP;ENST000

ENST00000263681:MtoT;

ENST00000268124:VtoA;ENST00000442287:VtoA;
ENST00000268124:StoA;ENST00000442287:StoA;
ENST00000268124:FtoV;ENST00000442287:FtoV;
ENST00000372236:QtoR;
ENST00000263857:WtoR;ENST00000409681:WtoR;
ENST00000263331:TtoS;ENST00000417433:TtoS;

ENST00000322644:NtoK;
ENST00000322644:LtoP;
ENST00000314595:LtoQ;ENST00000381227:LtoQ;

ENST00000372371:LtoH;

106

+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+

+
+
+

+
+

+
+
+
+
+
+
+
+
+
+

AtoT
CtoT
TtoC
TtoA
AtoG
AtoG
TtoG
AtoC
AtoG
AtoT
TtoC
AtoG
AtoG
TtoG
GtoA
TtoG
CtoA
AtoC
TtoC
CtoA
TtoC
AtoC
GtoA
TtoG
AtoG
AtoC
TtoG
TtoC
CtoG
AtoG
TtoG
AtoC
AtoG
GtoA
AtoG
GtoA
TtoC
AtoC
CtoT
TtoA
TtoA
TtoC
TtoC
TtoC
TtoC
CtoG
TtoC
TtoC
TtoG
AtoG
AtoG
AtoG
TtoA
TtoC
TtoC
CtoA
AtoG
AtoG
AtoG
TtoG
TtoC
TtoC
TtoC
AtoG
TtoC
CtoA
AtoG
AtoC
CtoA
TtoA
TtoC
TtoG
TtoG
AtoG
TtoC
AtoT
TtoC
TtoC
TtoC
TtoA
TtoC
CtoA
TtoC
TtoA
TtoC
TtoG
CtoG
TtoC
AtoT
CtoT
AtoG
TtoA
TtoA
TtoC
TtoC
GtoC

0.1
0.1
0.1
0.1
0.1
0.1154
0.1
0.1
0.1
0.1818
0.1111
0.1053
0.1
0.1
0.1045
0.1
0.1111
0.1304
0.1
0.1
0.1
0.1
0.1429
0.1111
0.1
0.1818
0.1875
0.125
0.1538
0.1
0.1
0.1
0.1333
0.4286
0.1
0.7
0.16
0.1
0.3182
0.1
0.1
0.1
0.12
0.1429
0.1103
0.3
0.2
0.1667
0.1
0.1333
0.1
0.1111
0.1
0.1429
0.1
0.1
0.1
0.1
0.1429
0.1
0.1053
0.1
0.1111
0.1
0.1667
0.1429
0.1429
0.1
0.1
0.1
0.1
0.1538
0.1111
0.1
0.1
0.1
0.1538
0.1
0.1
0.1111
0.1
0.1304
0.1
0.1176
0.1
0.1
0.1
0.1
0.4
0.2
0.1053
0.1429
0.1
0.1
0.1
0.1111

0.1333
0.1333
0.1538
0.1
0.1538
0.1818
0.1
0.1
0.1
0.2
0.1667
0.1212
0.2143
0.1
0.1087
0.1
0.1154
0.1818
0.1
0.1667
0.1
0.1
0.3636
0.1579
0.1667
0.2667
0.2308
0.25
0.2
0.1216
0.1
0.125
0.1818
0.4375
0.1667
0.9091
0.1667
0.1667
0.6
0.1333
0.1111
0.1
0.1667
0.4167
0.1143
0.5455
0.3333
0.2143
0.1333
0.1875
0.125
0.1538
0.1333
0.1818
0.1
0.1429
0.1667
0.1
0.3
0.1304
0.1111
0.1
0.1667
0.1818
0.2
0.1667
0.24
0.1818
0.1429
0.125
0.1176
0.1818
0.3125
0.1
0.1
0.1
0.1579
0.1111
0.1538
0.1111
0.1111
0.1538
0.25
0.15
0.2
0.1111
0.1818
0.1176
0.9231
0.3636
0.1176
0.6667
0.1
0.1
0.1
0.1538

3
2
3
2
2
2
2
3
2
4
9
3
3
4
4
2
5
2
2
2
4
2
4
6
3
2
4
11
5
2
3
2
3
2
2
2
4
2
2
3
5
2
7
5
5
7
5
3
4
3
2
3
6
3
3
2
2
2
5
4
2
3
11
2
3
2
5
2
2
3
5
6
9
2
2
2
3
3
3
2
2
2
6
10
5
3
3
6
4
7
5
9
2
3
2
2

2
2
2
2
2
2
2
2
2
3
3
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
6
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
3
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
3
2
2
2
3
2
2
2
2
3
4
2
2
2
2
2
2
2
2
2
4
3
2
2
2
2
4
7
3
8
2
2
2
2

[10,15]
[10,15]
[10,13]
[10,10]
[10,13]
[11,26]
[10,10]
[10,10]
[10,10]
[10,27]
[13,38]
[19,36]
[10,14]
[10,10]
[67,138]
[10,10]
[18,26]
[11,23]
[10,10]
[10,12]
[10,10]
[10,10]
[11,14]
[18,19]
[10,12]
[11,15]
[13,16]
[10,30]
[10,13]
[40,74]
[10,10]
[10,16]
[11,15]
[14,16]
[10,12]
[10,11]
[18,25]
[10,12]
[10,22]
[10,15]
[10,18]
[10,10]
[12,25]
[12,28]
[37,138]
[10,11]
[15,18]
[14,18]
[10,15]
[16,16]
[10,16]
[13,18]
[10,15]
[11,14]
[10,10]
[14,20]
[10,12]
[10,10]
[10,41]
[10,23]
[18,19]
[10,20]
[12,30]
[10,11]
[10,19]
[14,18]
[21,25]
[10,11]
[10,14]
[10,16]
[10,17]
[11,25]
[14,18]
[10,10]
[10,10]
[10,10]
[13,19]
[10,10]
[10,13]
[10,36]
[18,20]
[13,23]
[10,20]
[18,20]
[10,10]
[10,10]
[10,11]
[10,17]
[10,16]
[10,16]
[19,35]
[10,26]
[10,10]
[10,10]
[10,10]
[13,18]

TableS10

chr19:575856
chr5:6808769
chr5:6809110
chr5:6809650
chr1:46435288
chr1:46428198
chr13:28150337
chr9:133388249
chr9:133387318
chr9:133388436
chr8:99237725
chr8:99222201
chr11:110728197
chr1:165651818
chr1:165656320
chr1:165659439
chr19:47288084
chr19:47287896
chr19:47286210
chr10:71644307
chr4:106510200
chr19:10082971
chr19:10083413
chr5:54756447
chr8:38241277
chr5:149213571
chr15:73129111
chr15:73129114
chr20:61623960
chr12:27725875
chr12:27739015
chr12:27568528
chr12:41121926
chr7:44805604
chr7:44805960
chr7:44805563
chr7:44805564
chr7:44805962
chr7:44805826
chr7:44805827
chr7:44805971
chr7:44805832
chr7:44804874
chr7:44804875
chr7:44804919
chr7:44805562
chr7:44807700
chr7:44807707
chr7:44807708
chr7:44807716
chr7:44807718
chr7:44807753
chr7:44807912
chr7:44807913
chr7:44808624
chr7:44802808
chr7:44802814
chr4:159856180
chr4:159856179
chr4:159861955
chr10:80783553
chr10:80784359
chr2:170196594
chr6:36930914
chr6:36930916
chr6:36931104
chr6:149868288
chr6:149898490
chr6:149903846
chr6:149896301
chr6:149903793
chr6:149889513
chr6:149883990
chr6:149903854
chr6:149889570
chr6:149896293
chr6:149898556
chr6:149868253
chr6:149868259
chr14:49150725
chr14:59829723
chr2:44282051
chr2:44298720
chr17:56066055
chr4:89397983
chr4:89401782
chr3:52258018
chr1:159407896
chr1:159407897
chr11:66930738
chr11:66930881
chr11:66922228
chr12:109643117
chr12:109642003
chr6:30676633
chr12:78693720

POLRMT
POLS
POLS
POLS
POMGNT1
POMGNT1
POMP
POMT1
POMT1
POMT1
POP1
POP1
POU2AF1
POU2F1
POU2F1
POU2F1
POU2F2
POU2F2
POU2F2
PPA1
PPA2
PPAN
PPAN
PPAP2A
PPAPDC1B
PPARGC1B
PPCDC
PPCDC
PPDPF
PPFIBP1
PPFIBP1
PPFIBP1
PPHLN1
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPIA
PPID
PPID
PPID
PPIF
PPIF
PPIG
PPIL1
PPIL1
PPIL1
PPIL4
PPIL4
PPIL4
PPIL4
PPIL4
PPIL4
PPIL4
PPIL4
PPIL4
PPIL4
PPIL4
PPIL4
PPIL4
PPIL5
PPM1A
PPM1B
PPM1B
PPM1D
PPM1K
PPM1K
PPM1M
PPOX
PPOX
PPP1CA
PPP1CA
PPP1CA
PPP1CC
PPP1CC
PPP1R10
PPP1R12A

coding_exon
UTR3
UTR3
UTR3
coding_exon
mixed
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR5
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR5
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
mixed
mixed
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
mixed
UTR3
UTR3
UTR3

ENST00000215591:TtoP;ENST00000432652:TtoP;

ENST00000371984:LtoP;ENST00000371986:LtoP;ENST00000371992:LtoP;ENST0000

ENST00000341012:StoP;ENST00000354713:StoP;ENST00000372228:StoP;ENST000
ENST00000341012:LtoP;ENST00000354713:LtoP;ENST00000372228:LtoP;ENST0000
ENST00000349693:CtoG;ENST00000401707:CtoG;

ENST00000292077:LtoF;ENST00000342301:LtoF;ENST00000389341:LtoF;

ENST00000373230:CtoW;ENST00000373232:CtoW;

ENST00000317577:VtoL;ENST00000424479:VtoL;

ENST00000451562:QtoH;ENST00000468812:QtoH;
ENST00000451562:NtoK;ENST00000468812:NtoK;
ENST00000451562:GtoS;ENST00000468812:GtoS;
ENST00000451562:GtoD;ENST00000468812:GtoD;
ENST00000451562:GtoD;ENST00000468812:GtoD;
ENST00000451562:GtoC;ENST00000468812:GtoC;
ENST00000451562:GtoA;ENST00000468812:GtoA;
ENST00000451562:FtoS;ENST00000468812:FtoS;
ENST00000451562:DtoH;ENST00000468812:DtoH;

ENST00000307720:DtoG;
ENST00000307720:DtoE;

ENST00000340881:ItoT;
ENST00000253329:MtoI;
ENST00000253329:KtoN;
ENST00000253329:ItoL;
ENST00000253329:GtoD;
ENST00000253329:EtoD;
ENST00000253329:CtoY;
ENST00000253329:AtoT;

ENST00000298288:ItoF;ENST00000318317:DtoV;

ENST00000305921:NtoI;ENST00000392995:NtoI;

ENST00000296487:LtoI;ENST00000323588:LtoI;ENST00000409502:LtoI;

107

+
+
+

+
+
+
+
+
+

+
+
+

+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+

+
+
+
+
+

+
+
+

AtoC
AtoC
TtoC
TtoG
TtoC
TtoC
GtoA
TtoC
TtoC
GtoC
TtoG
AtoG
TtoC
CtoA
TtoG
AtoG
GtoT
AtoG
GtoA
TtoG
AtoG
CtoA
TtoC
AtoG
GtoC
AtoG
GtoA
AtoG
TtoA
TtoG
TtoA
AtoT
TtoA
GtoC
TtoA
GtoA
GtoA
GtoA
GtoT
GtoC
TtoC
GtoC
AtoC
AtoG
GtoA
GtoA
TtoC
AtoG
TtoA
TtoA
AtoC
TtoA
AtoG
AtoG
AtoG
TtoC
AtoC
AtoG
TtoA
TtoG
TtoC
TtoA
TtoC
TtoG
AtoG
TtoG
TtoC
GtoT
AtoC
AtoT
GtoA
AtoT
GtoA
GtoA
AtoG
GtoA
CtoT
AtoG
AtoT
AtoT
AtoC
AtoT
AtoG
AtoT
TtoG
CtoA
TtoA
AtoC
AtoT
AtoT
AtoC
CtoA
AtoG
AtoG
TtoC
AtoG

0.1667
0.1
0.1111
0.1
0.1
0.1
0.1053
0.1
0.1176
0.1
0.1
0.1
0.1053
0.1818
0.1667
0.1
0.1273
0.2667
0.1
0.1132
0.1429
0.6667
0.125
0.1
0.1
0.1
0.1053
0.1
0.1064
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1111
0.15
0.1034
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1026
0.1
0.1
0.1176
0.1
0.125
0.1042
0.1912
0.1
0.125
0.1
0.1429
0.1053
0.1111
0.1136
0.1034
0.1
0.125
0.1071
0.1818
0.1333
0.1111
0.125
0.1818
0.125
0.1
0.1
0.1
0.1053
0.1
0.1
0.1111
0.1
0.1053
0.1
0.125
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.125
0.1136
0.1
0.1053
0.1176

0.1667
0.1
0.1176
0.1333
0.1176
0.1
0.16
0.1
0.1667
0.1
0.15
0.1071
0.2273
0.25
0.3
0.1
0.25
0.3077
0.125
0.15
0.1818
0.9231
0.2
0.1538
0.1
0.1
0.1538
0.1
0.12
0.1
0.1
0.1
0.1538
0.1429
0.1667
0.4
0.1111
0.2308
0.2308
0.1429
0.1818
0.1053
0.12
0.1071
0.5769
0.1176
0.1212
0.125
0.2381
0.7222
0.6875
0.4545
0.1724
0.45
0.6522
0.1
0.125
0.1538
0.1818
0.1538
0.1296
0.1667
0.11
0.1
0.1818
0.1333
0.3636
0.1818
0.2143
0.1875
0.3333
0.1667
0.1818
0.1818
0.1053
0.25
0.1667
0.1538
0.25
0.1
0.1429
0.1667
0.129
0.1
0.125
0.1667
0.1
0.1154
0.1304
0.1034
0.1053
0.1364
0.1333
0.1818
0.12
0.1818

6
2
3
2
2
3
8
3
4
3
2
2
12
2
2
4
4
3
7
11
5
3
3
6
2
2
3
3
7
2
2
2
6
4
14
13
5
11
8
3
6
6
9
9
14
5
3
5
4
7
10
12
11
15
19
2
2
7
7
6
3
7
3
4
2
6
6
4
5
9
3
3
5
4
5
10
2
5
7
4
3
2
3
2
6
2
2
3
3
4
2
8
4
6
7
2

2
2
2
2
2
2
3
2
2
2
2
2
5
2
2
2
3
2
3
5
3
3
2
4
2
2
2
2
2
2
2
2
5
2
6
10
2
4
6
2
3
2
4
2
10
2
2
2
2
7
9
9
4
14
19
2
2
3
4
2
2
2
2
2
2
2
5
2
3
3
2
2
3
3
2
6
2
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
3
3
2
2

[12,18]
[10,10]
[18,18]
[10,15]
[10,17]
[10,10]
[19,47]
[10,10]
[12,17]
[10,10]
[10,20]
[10,28]
[17,38]
[11,16]
[10,12]
[10,10]
[40,55]
[13,15]
[16,20]
[20,296]
[11,14]
[11,15]
[10,16]
[10,19]
[10,10]
[10,10]
[13,19]
[10,10]
[25,51]
[10,10]
[10,10]
[10,10]
[10,25]
[10,21]
[10,28]
[16,72]
[18,27]
[13,33]
[13,32]
[10,28]
[10,14]
[19,40]
[20,34]
[20,28]
[24,43]
[17,30]
[36,48]
[24,39]
[10,22]
[17,35]
[16,36]
[10,28]
[22,32]
[15,48]
[11,69]
[10,10]
[16,24]
[10,15]
[12,18]
[13,20]
[27,54]
[20,46]
[29,102]
[10,10]
[11,24]
[15,28]
[11,22]
[11,15]
[14,18]
[13,24]
[11,12]
[12,16]
[10,11]
[11,20]
[10,19]
[12,26]
[12,20]
[10,14]
[12,18]
[10,10]
[14,20]
[10,12]
[16,31]
[10,10]
[10,16]
[10,12]
[10,10]
[20,26]
[19,23]
[10,30]
[10,19]
[22,40]
[15,44]
[12,22]
[20,26]
[11,17]

TableS10

chr11:63768983
chr11:63768824
chr11:63770495
chr1:28040250
chr17:45567647
chr5:133560909
chr8:30771337
chr19:57385101
chr11:111140790
chr10:133603593
chr9:130951040
chr1:210600732
chr11:64451883
chr14:101463267
chr14:101463268
chr14:101463289
chr14:101463317
chr14:101463360
chr14:63076069
chr14:63079666
chr10:74876340
chr10:74876339
chr10:74867702
chr2:68259808
chr2:68261334
chr2:68261339
chr18:9537102
chr3:73195927
chr22:40325171
chr22:40325172
chr22:40325206
chr22:40325230
chr22:40325252
chr22:40325496
chr22:40326270
chr22:40326274
chr22:40326309
chr10:103890952
chr10:103894052
chr5:64918951
chr5:64918956
chr5:64914621
chr5:64894960
chr18:75764108
chr15:89326052
chr6:106660942
chr6:106660943
chr1:13977665
chr1:13978970
chr1:13981129
chr1:13978379
chr1:13977827
chr1:13978221
chr1:13985773
chr1:13986214
chr19:12771996
chr19:12768642
chr6:105843439
chr6:105832372
chr2:44419802
chr20:46729329
chr20:46675182
chr20:46675247
chr11:56913129
chr5:40813424
chr5:40803534
chr12:118603215
chr19:14064944
chr19:14064409
chr12:47693156
chr17:64030649
chr17:64030648
chr17:64038748
chr17:64039437
chr17:64039739
chr17:64039745
chr17:64040239
chr17:64040427
chr17:64040428
chr3:48760251
chr3:48763496
chr16:24134452
chr16:24134797
chr16:24134802
chr16:24134803
chr16:24138012
chr16:24138013
chr16:24138366
chr16:24139134
chr3:53201540
chr11:6297351
chr11:6297350
chr19:51869415
chr19:51869418
chr19:51911760
chr19:51911761

PPP1R14B
PPP1R14B
PPP1R14B
PPP1R8
PPP1R9B
PPP2CA
PPP2CB
PPP2R1A
PPP2R1B
PPP2R2D
PPP2R4
PPP2R5A
PPP2R5B
PPP2R5C
PPP2R5C
PPP2R5C
PPP2R5C
PPP2R5C
PPP2R5E
PPP2R5E
PPP3CB
PPP3CB
PPP3CB
PPP3R1
PPP3R1
PPP3R1
PPP4R1
PPP4R2
PPPDE2
PPPDE2
PPPDE2
PPPDE2
PPPDE2
PPPDE2
PPPDE2
PPPDE2
PPPDE2
PPRC1
PPRC1
PPWD1
PPWD1
PPWD1
PPWD1
PQLC1
PRC1
PRDM1
PRDM1
PRDM2
PRDM2
PRDM2
PRDM2
PRDM2
PRDM2
PRDM2
PRDM2
PRDX2
PRDX2
PREP
PREP
PREPL
PREX1
PREX1
PREX1
PRG2
PRKAA1
PRKAA1
PRKAB1
PRKACA
PRKACA
PRKAG1
PRKAR1A
PRKAR1A
PRKAR1A
PRKAR1A
PRKAR1A
PRKAR1A
PRKAR1A
PRKAR1A
PRKAR1A
PRKAR2A
PRKAR2A
PRKCB
PRKCB
PRKCB
PRKCB
PRKCB
PRKCB
PRKCB
PRKCB
PRKCD
PRKCDBP
PRKCDBP
PRKD2
PRKD2
PRKD2
PRKD2

coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
UTR5
coding_exon
UTR5
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR5
coding_exon
coding_exon
UTR3
mixed
mixed
mixed
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR5
UTR5

ENST00000309318:TtoA;
ENST00000309318:LtoP;
ENST00000309318:LtoP;

ENST00000164133:StoG;

ENST00000337537:StoP;
ENST00000394828:VtoE;ENST00000394829:VtoE;

ENST00000356692:LtoW;ENST00000394284:LtoW;

ENST00000261308:VtoA;
ENST00000261308:ItoV;
ENST00000261308:FtoL;
ENST00000261308:EtoK;
ENST00000361188:StoT;ENST00000361919:StoT;ENST00000394249:StoT;ENST0000
ENST00000071246:HtoY;ENST00000369089:HtoY;ENST00000369091:HtoY;ENST000
ENST00000071246:HtoR;ENST00000369089:HtoR;ENST00000369091:HtoR;ENST00
ENST00000235372:VtoA;ENST00000311066:VtoA;ENST00000343137:VtoA;ENST00
ENST00000235372:QtoR;ENST00000311066:QtoR;ENST00000343137:QtoR;ENST00
ENST00000235372:KtoE;ENST00000311066:KtoE;ENST00000343137:KtoE;ENST000
ENST00000235372:HtoR;ENST00000311066:HtoR;ENST00000343137:HtoR;ENST00
ENST00000235372:EtoG;ENST00000311066:EtoG;ENST00000343137:EtoG;ENST000

ENST00000371941:HtoP;ENST00000396220:HtoP;

ENST00000311862:VtoA;
ENST00000296800:GtoE;ENST00000354209:GtoE;ENST00000397128:GtoE;

ENST00000308677:KtoE;ENST00000350356:KtoE;

ENST00000358598:StoY;ENST00000392710:StoY;ENST00000392711:StoY;
ENST00000358598:StoA;ENST00000392710:StoA;ENST00000392711:StoA;

ENST00000303927:AtoD;

108

+
+
+
+
+
+
+
+
+

+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+

AtoG
TtoC
TtoC
TtoG
TtoC
TtoA
AtoC
GtoC
GtoT
GtoA
CtoG
AtoG
AtoG
TtoC
GtoT
TtoC
GtoA
TtoA
TtoC
TtoG
TtoA
AtoT
TtoC
AtoG
TtoG
TtoC
AtoG
TtoG
TtoA
TtoA
AtoG
AtoG
AtoG
TtoC
CtoT
AtoG
AtoG
TtoC
AtoC
TtoC
AtoG
TtoC
GtoA
TtoG
GtoC
CtoT
AtoG
TtoC
AtoG
AtoG
AtoG
AtoG
TtoC
TtoC
CtoT
TtoC
AtoG
TtoC
TtoA
TtoC
AtoC
AtoG
AtoC
TtoC
GtoA
AtoG
TtoC
AtoG
TtoG
TtoG
CtoA
TtoG
TtoA
AtoG
TtoC
TtoA
TtoG
CtoA
TtoG
CtoG
TtoA
GtoT
TtoC
AtoC
TtoA
CtoA
TtoC
TtoA
AtoG
TtoC
CtoA
CtoG
GtoA
TtoC
TtoA
TtoG

0.1
0.1
0.12
0.1111
0.75
0.1
0.1
0.1
0.1
0.1
0.1538
0.1
0.1
0.1
0.1
0.1
0.1
1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1333
0.1
0.1111
0.1
0.1579
0.1
0.1364
0.1
0.1
0.1
0.1
0.12
0.1
0.1
0.1154
0.1111
0.4762
0.1026
0.1
0.1111
0.1
0.125
0.1
0.1
0.1
0.1111
0.1
1
0.1
0.1
0.1
0.1
0.1429
0.1111
0.1489
0.1
0.1
0.1
0.1
0.1
0.1071
0.1
0.1
0.1169
0.1429
0.1304
0.1
0.1
0.1
0.1034
0.1176
0.1
0.1
0.1176
0.1111
0.1
0.125
0.1176
0.1333
0.1111
0.1111
0.1
0.1
0.1
0.1818
0.1
0.1
0.1

0.2759
0.2308
0.3125
0.1818
1
0.1429
0.125
0.2143
0.1
0.1
0.3
0.1
0.1
0.1176
0.1111
0.2
0.1818
1
0.1364
0.1
0.25
0.2727
0.1111
0.1111
0.1818
0.1818
0.1
0.3636
0.1875
0.2308
0.5455
0.2727
0.1923
0.2
0.16
0.125
0.1429
0.1
0.1
0.1667
0.3
0.125
0.1923
0.1111
0.75
0.2727
0.2308
0.1818
0.1818
0.1667
0.1
0.15
0.1
0.1176
0.1
1
0.1795
0.1176
0.2
0.1111
0.2667
0.1429
0.2105
0.1818
0.1
0.1429
0.1
0.1667
0.1176
0.1053
0.1029
0.2075
0.1429
0.2
0.1053
0.1818
0.1
0.1667
0.125
0.1
0.1
0.1429
0.1111
0.1111
0.2
0.12
0.1364
0.125
0.1429
0.25
0.1667
0.1667
0.1818
0.2727
0.1
0.1

12
4
8
9
2
2
3
2
2
2
2
2
3
8
7
3
7
12
6
2
11
12
3
4
2
6
2
4
3
3
12
3
4
2
8
2
5
2
2
6
3
2
9
2
2
6
6
3
2
2
2
3
3
3
2
15
4
2
2
5
8
7
6
2
2
2
2
7
2
2
5
10
5
11
9
5
2
2
4
2
2
2
3
6
5
3
3
5
4
10
3
2
2
4
2
2

8
3
8
5
2
2
2
2
2
2
2
2
2
3
2
2
2
12
2
2
10
10
2
2
2
2
2
4
2
3
10
2
2
2
2
2
2
2
2
3
3
2
4
2
2
3
4
2
2
2
2
2
2
2
2
15
4
2
2
2
3
2
2
2
2
2
2
2
2
2
2
3
2
5
2
4
2
2
2
2
2
2
2
2
3
2
2
2
2
6
2
2
2
2
2
2

[13,31]
[11,16]
[15,66]
[22,27]
[12,12]
[10,14]
[10,16]
[10,14]
[10,10]
[10,10]
[10,13]
[10,10]
[10,10]
[17,20]
[10,18]
[20,20]
[10,11]
[10,23]
[10,22]
[10,20]
[12,27]
[10,29]
[10,18]
[10,18]
[11,11]
[10,23]
[10,10]
[10,15]
[15,16]
[10,15]
[10,26]
[11,30]
[19,26]
[10,10]
[23,25]
[16,20]
[10,14]
[10,10]
[10,10]
[12,26]
[10,10]
[10,16]
[25,28]
[10,10]
[12,21]
[11,39]
[10,28]
[10,11]
[10,11]
[12,16]
[10,11]
[10,20]
[10,10]
[17,18]
[10,10]
[16,269]
[10,39]
[10,17]
[10,10]
[10,18]
[15,34]
[14,18]
[19,47]
[10,11]
[10,10]
[10,14]
[10,10]
[18,20]
[17,28]
[10,19]
[68,80]
[53,77]
[14,28]
[10,24]
[19,20]
[10,23]
[10,10]
[12,29]
[18,32]
[10,10]
[10,10]
[14,17]
[18,27]
[10,18]
[10,19]
[17,25]
[16,22]
[10,33]
[14,18]
[12,23]
[10,12]
[10,12]
[11,11]
[10,11]
[10,10]
[10,10]

TableS10

chr8:48964177
chr8:48915208
chr8:48896783
chr8:48857348
chr8:48956544
chr8:48848755
chr10:53127582
chr2:179005012
chr19:54883513
chr4:148813601
chr1:107402447
chr16:66931289
chr16:66912865
chr11:60430606
chr1:148583550
chr1:148571780
chr1:148592264
chr1:52655038
chr1:52655282
chr1:52655283
chr1:52655703
chr1:109040479
chr1:109040481
chr14:44649047
chr9:115094711
chr2:153228981
chr2:153220788
chr12:48317520
chr12:48321983
chr12:48321984
chr12:48322992
chr12:48316895
chr12:48316896
chr12:48321221
chr12:48321600
chr12:48323468
chr12:48324680
chr6:3987728
chr17:1500709
chr17:71818639
chr17:18721825
chr17:18774922
chr17:18774972
chr19:54789801
chr12:52126682
chr19:47498319
chr6:30639279
chr6:30639281
chr5:176815373
chr5:126888126
chr5:126915608
chr5:126917660
chr3:9963279
chr3:9963475
chr3:9965473
chr1:149274491
chr10:73251776
chr10:73251775
chr10:73246063
chr14:72729299
chr14:72756715
chr1:225144382
chr11:14483116
chr15:76628588
chr1:109770561
chr1:109770563
chr14:34856415
chr16:66525921
chr16:66525923
chr1:35840005
chr1:149641004
chr1:149638680
chr1:149638681
chr9:126155567
chr9:126155568
chr9:126155569
chr9:126155570
chr6:32933029
chr6:32935334
chr6:32935337
chr6:32935338
chr6:32935339
chr6:32935344
chr6:32935446
chr6:32935541
chr11:47396904
chr2:161976399
chr3:185507243
chr17:35407730
chr1:149506399
chr1:149506394
chr1:149506309
chr1:149506430
chr1:149506406
chr1:149506398
chr1:149506431

PRKDC
PRKDC
PRKDC
PRKDC
PRKDC
PRKDC
PRKG1
PRKRA
PRMT1
PRMT10
PRMT6
PRMT7
PRMT7
PRPF19
PRPF3
PRPF3
PRPF3
PRPF38A
PRPF38A
PRPF38A
PRPF38A
PRPF38B
PRPF38B
PRPF39
PRPF4
PRPF40A
PRPF40A
PRPF40B
PRPF40B
PRPF40B
PRPF40B
PRPF40B
PRPF40B
PRPF40B
PRPF40B
PRPF40B
PRPF40B
PRPF4B
PRPF8
PRPSAP1
PRPSAP2
PRPSAP2
PRPSAP2
PRR12
PRR13
PRR19
PRR3
PRR3
PRR7
PRRC1
PRRC1
PRRC1
PRRT3
PRRT3
PRRT3
PRUNE
PSAP
PSAP
PSAP
PSEN1
PSEN1
PSEN2
PSMA1
PSMA4
PSMA5
PSMA5
PSMA6
PSMB10
PSMB10
PSMB2
PSMB4
PSMB4
PSMB4
PSMB7
PSMB7
PSMB7
PSMB7
PSMB9
PSMB9
PSMB9
PSMB9
PSMB9
PSMB9
PSMB9
PSMB9
PSMC3
PSMD14
PSMD2
PSMD3
PSMD4
PSMD4
PSMD4
PSMD4
PSMD4
PSMD4
PSMD4

coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
coding_exon
mixed
coding_exon
coding_exon
UTR5
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
mixed
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR5
UTR3
UTR3
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR5
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon

ENST00000314191:YtoD;ENST00000338368:YtoD;
ENST00000314191:VtoA;ENST00000338368:VtoA;
ENST00000314191:TtoP;ENST00000338368:TtoP;
ENST00000314191:LtoR;
ENST00000314191:DtoY;ENST00000338368:DtoY;

ENST00000339507:WtoR;ENST00000348497:WtoR;ENST00000441236:WtoR;ENST0
ENST00000339507:RtoK;ENST00000348497:RtoK;ENST00000441236:RtoK;ENST000
ENST00000324862:NtoD;ENST00000414970:NtoD;
ENST00000324862:ItoS;ENST00000414970:ItoS;

ENST00000370021:EtoD;ENST00000370022:EtoD;ENST00000370025:EtoD;
ENST00000370021:EtoA;ENST00000370022:EtoA;ENST00000370025:EtoA;

ENST00000356402:QtoR;ENST00000359961:QtoR;ENST00000410080:QtoR;ENST00
ENST00000261897:TtoA;ENST00000341308:TtoA;ENST00000380281:TtoA;ENST000
ENST00000261897:NtoS;ENST00000341308:NtoS;ENST00000380281:NtoS;ENST000
ENST00000261897:NtoK;ENST00000341308:NtoK;ENST00000380281:NtoK;ENST00
ENST00000261897:HtoN;ENST00000341308:HtoN;ENST00000380281:HtoN;ENST00
ENST00000261897:FtoS;ENST00000341308:FtoS;ENST00000380281:FtoS;ENST0000

ENST00000337659:DtoV;

ENST00000268835:YtoS;ENST00000395656:YtoS;ENST00000419071:YtoS;

ENST00000418929:StoP;

ENST00000323249:VtoG;ENST00000355386:VtoG;

ENST00000295984:ItoL;ENST00000412055:ItoL;

ENST00000394934:LtoV;
ENST00000394934:LtoH;
ENST00000261970:LtoH;ENST00000324501:LtoH;ENST00000344094:LtoH;ENST000
ENST00000366782:KtoE;ENST00000366783:KtoE;ENST00000391872:KtoE;ENST000

ENST00000374859:VtoG;ENST00000395330:VtoG;ENST00000453265:VtoG;

ENST00000310118:VtoG;ENST00000435761:VtoG;ENST00000439383:VtoG;
ENST00000368881:TtoA;ENST00000368884:TtoA;ENST00000418119:TtoA;ENST000
ENST00000368881:QtoP;ENST00000368884:QtoP;ENST00000418119:QtoP;ENST00
ENST00000368881:FtoI;ENST00000368884:FtoI;ENST00000418119:FtoI;ENST00000
ENST00000368881:EtoA;ENST00000368884:EtoA;ENST00000418119:EtoA;ENST000
ENST00000368881:DtoA;ENST00000368884:DtoA;ENST00000418119:DtoA;ENST00

109

+
+
+

+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+

+
+
+

+
+
+

+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+

TtoG
TtoC
AtoC
TtoG
GtoT
TtoA
AtoT
TtoA
TtoC
GtoT
TtoA
TtoC
GtoA
GtoT
AtoG
TtoG
TtoG
TtoA
TtoA
TtoA
AtoG
AtoT
AtoC
TtoG
AtoC
AtoG
AtoC
AtoG
AtoG
CtoG
CtoA
TtoC
CtoT
TtoA
CtoA
TtoC
GtoT
AtoT
TtoG
TtoC
AtoC
AtoG
TtoC
TtoC
TtoC
TtoC
TtoC
GtoA
TtoG
AtoG
TtoA
TtoG
AtoC
AtoG
AtoG
AtoG
CtoG
TtoA
AtoG
TtoA
AtoG
AtoG
TtoC
AtoG
AtoT
TtoG
AtoG
AtoG
AtoG
TtoA
TtoG
TtoG
GtoC
TtoA
CtoA
GtoA
AtoG
TtoG
GtoA
AtoG
AtoG
AtoG
GtoA
GtoA
AtoT
GtoA
AtoG
TtoG
TtoC
AtoG
AtoC
TtoA
AtoC
AtoC
CtoA
AtoG

0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1429
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1333
0.1
0.1111
0.1
0.1333
0.1
0.1034
0.1
0.2
0.1
0.1111
0.1053
0.1538
0.1053
0.1053
0.1
0.1
0.1
0.125
0.1053
0.15
0.1
0.1
0.1111
0.1111
0.1333
0.1
0.1538
0.1667
0.1429
0.1
0.1429
0.1
0.1818
0.1
0.1
0.1
1
0.1
0.1
0.1333
0.1053
0.1
0.1
0.1818
0.1111
0.1
0.1169
0.1
0.1
0.1
0.1
0.1333
0.1053
0.1
0.1667
0.1
0.1
0.1818
0.1
0.1
0.1
0.1
0.12
0.1064
0.1333
0.1
0.1176
0.1
0.2
0.1
0.1111
0.1143
0.1
0.1
0.1
0.1071
0.1
0.1333
0.2222
0.1

0.1
0.1
0.1765
0.1034
0.1
0.1818
0.1429
0.1667
0.3
0.1
0.1667
0.1176
0.125
0.2
0.2
0.2353
0.2
0.1538
0.45
0.3571
0.125
0.1053
0.1429
0.4545
0.1429
0.1111
0.1333
0.5
0.25
0.1667
0.2
0.1875
0.25
0.125
0.125
0.1667
0.1
0.1429
0.125
0.2083
0.2222
0.1429
0.1818
0.1818
0.2857
0.1818
0.1538
0.1
0.2
0.1538
0.1
0.1
1
0.1
0.1429
0.2
0.3846
0.3846
0.1875
0.2
0.1818
0.1
0.1786
0.1667
0.1765
0.1538
0.1818
0.2
0.1364
0.1111
0.2
0.1
0.1818
0.2222
0.3077
0.3
0.125
0.1624
0.1667
0.375
0.2
0.1053
0.1176
0.1818
0.3
0.1538
0.1429
0.1184
0.2727
0.1667
0.1538
0.1786
0.6875
0.2143
0.25
0.4

3
2
4
7
2
2
2
3
12
2
4
3
6
2
2
3
3
5
15
12
4
7
10
6
3
4
2
4
12
10
3
8
10
4
5
4
2
2
7
2
2
5
8
2
2
5
7
3
3
3
2
3
4
2
2
5
7
4
5
3
4
2
4
2
5
4
4
3
14
5
7
2
2
5
8
11
7
4
4
18
8
5
2
4
2
9
7
5
5
2
2
7
5
2
3
6

2
2
2
2
2
2
2
2
5
2
2
2
2
2
2
2
2
3
11
3
2
2
4
4
2
2
2
4
9
6
3
4
5
2
2
3
2
2
2
2
2
2
2
2
2
4
3
2
2
2
2
2
4
2
2
3
5
2
3
2
2
2
2
2
2
2
3
2
5
2
2
2
2
2
3
6
2
2
3
14
2
2
2
3
2
4
3
2
4
2
2
5
3
2
2
4

[10,10]
[10,10]
[10,17]
[10,29]
[10,20]
[10,11]
[10,14]
[12,14]
[10,25]
[10,10]
[10,12]
[10,17]
[16,19]
[10,10]
[10,10]
[15,17]
[10,11]
[10,15]
[13,24]
[14,15]
[10,16]
[19,29]
[17,21]
[10,12]
[10,14]
[18,18]
[15,19]
[10,15]
[16,53]
[15,57]
[10,24]
[10,16]
[10,17]
[16,24]
[16,19]
[12,20]
[10,10]
[10,14]
[10,26]
[10,24]
[16,18]
[14,20]
[11,13]
[11,12]
[14,15]
[11,49]
[13,14]
[10,10]
[10,11]
[10,13]
[10,10]
[10,10]
[10,33]
[10,10]
[10,14]
[10,15]
[10,19]
[10,13]
[10,17]
[11,11]
[11,18]
[10,10]
[29,80]
[10,12]
[11,17]
[10,13]
[10,11]
[10,15]
[19,54]
[18,20]
[12,21]
[10,20]
[10,12]
[10,12]
[10,15]
[10,19]
[10,16]
[60,435]
[15,25]
[15,47]
[10,16]
[10,19]
[17,17]
[10,16]
[10,10]
[10,26]
[14,19]
[80,140]
[10,19]
[10,13]
[11,13]
[19,30]
[10,23]
[15,15]
[10,12]
[10,20]

TableS10

chr1:149501316
chr1:149501318
chr1:149501320
chr1:149501330
chr1:149503099
chr1:149504291
chr1:149505434
chr1:149505461
chr1:149506499
chr14:23677620
chr14:23678010
chr14:23678012
chr14:23683244
chr14:23682645
chr14:23684322
chr14:23682660
chr14:23682668
chr14:23683278
chr14:23684195
chr14:23682662
chr14:23683262
chr14:23682664
chr14:23683063
chr14:23683264
chr14:23683279
chr14:23682413
chr17:38240075
chr2:53976258
chr2:53999792
chr13:19149868
chr7:56056319
chr10:124744163
chr1:28350077
chr19:755407
chr19:750431
chr19:762320
chr19:763311
chr19:763313
chr2:86207937
chr2:86221715
chr2:86222007
chr10:89717058
chr10:89613600
chr8:27352808
chr8:27372811
chr8:27239007
chr2:232284316
chr2:232284326
chr2:232285767
chr2:232284324
chr2:232284315
chr2:232284937
chr2:232284320
chr2:232285469
chr2:232285762
chr2:232284936
chr2:232285410
chr2:232285464
chr2:232285766
chr2:232285793
chr2:232285398
chr2:232281481
chr2:232281484
chr2:232281490
chr2:232281492
chr2:232281614
chr2:232281619
chr2:232285991
chr2:232285992
chr2:232285994
chr2:232286002
chr2:232286059
chr2:232286060
chr2:232286093
chr2:232286111
chr2:232286112
chr2:232286280
chr2:232286290
chr2:232286291
chr12:6750362
chr19:55055410
chr19:55055681
chr19:55055792
chr15:63636158
chr15:63656451
chr15:63657271
chr3:124695945
chr11:47549931
chr20:48634595
chr7:77094405
chr7:77038379
chr2:130847659
chr3:47429377
chr12:6940728
chr12:6940737
chr15:73547227

PSMD4
PSMD4
PSMD4
PSMD4
PSMD4
PSMD4
PSMD4
PSMD4
PSMD4
PSME1
PSME1
PSME1
PSME2
PSME2
PSME2
PSME2
PSME2
PSME2
PSME2
PSME2
PSME2
PSME2
PSME2
PSME2
PSME2
PSME2
PSME3
PSME4
PSME4
PSPC1
PSPH
PSTK
PTAFR
PTBP1
PTBP1
PTBP1
PTBP1
PTBP1
PTCD3
PTCD3
PTCD3
PTEN
PTEN
PTK2B
PTK2B
PTK2B
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMA
PTMS
PTOV1
PTOV1
PTOV1
PTPLAD1
PTPLAD1
PTPLAD1
PTPLB
PTPMT1
PTPN1
PTPN12
PTPN12
PTPN18
PTPN23
PTPN6
PTPN6
PTPN9

mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
mixed
mixed
UTR3
coding_exon
mixed
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
mixed
UTR3
UTR3
UTR3
UTR5
coding_exon
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
coding_exon
UTR3
UTR3
UTR3

ENST00000382708:QtoR;

ENST00000216802:StoC;ENST00000396881:StoC;ENST00000429021:StoC;
ENST00000216802:RtoW;ENST00000396881:RtoW;ENST00000429021:RtoW;
ENST00000216802:MtoV;ENST00000396881:MtoV;ENST00000429021:MtoV;
ENST00000216802:MtoL;ENST00000396881:MtoL;ENST00000429021:MtoL;
ENST00000216802:LtoP;ENST00000396881:LtoP;ENST00000429021:LtoP;
ENST00000216802:KtoE;ENST00000396881:KtoE;ENST00000429021:KtoE;
ENST00000216802:CtoS;ENST00000396881:CtoS;ENST00000429021:CtoS;
ENST00000216802:AtoD;ENST00000396881:AtoD;ENST00000429021:AtoD;
ENST00000216802:AtoD;ENST00000396881:AtoD;ENST00000429021:AtoD;

ENST00000275605:RtoS;ENST00000395471:RtoS;

ENST00000349038:EtoG;ENST00000356948:EtoG;ENST00000394601:EtoG;

ENST00000338238:TtoP;ENST00000346049:TtoP;ENST00000397497:TtoP;ENST000

ENST00000358839:EtoK;
ENST00000341369:VtoL;ENST00000358839:VtoL;ENST00000409115:VtoL;ENST000
ENST00000341369:VtoI;ENST00000358839:VtoI;ENST00000409115:VtoI;ENST0000
ENST00000341369:VtoD;ENST00000409115:VtoD;ENST00000409321:VtoD;ENST00
ENST00000341369:KtoR;ENST00000409115:KtoR;ENST00000409321:KtoR;ENST000
ENST00000341369:GtoC;ENST00000358839:GtoC;ENST00000409115:GtoC;ENST00
ENST00000341369:EtoK;ENST00000358839:GtoE;ENST00000409115:EtoK;ENST000
ENST00000341369:EtoG;ENST00000358839:EtoG;ENST00000409115:EtoG;ENST000
ENST00000341369:DtoG;ENST00000358839:DtoG;ENST00000409115:DtoG;ENST00
ENST00000341369:DtoE;ENST00000358839:DtoE;ENST00000409115:DtoE;ENST000
ENST00000341369:DtoE;ENST00000358839:DtoE;ENST00000409115:DtoE;ENST000
ENST00000341369:DtoE;ENST00000358839:DtoE;ENST00000409115:DtoE;ENST000
ENST00000341369:DtoE;ENST00000358839:DtoE;ENST00000409115:DtoE;ENST000
ENST00000341369:DtoE;ENST00000358839:DtoE;ENST00000409115:DtoE;ENST000

ENST00000261875:VtoE;

ENST00000265562:StoP;

110

+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+

GtoA
CtoG
AtoG
TtoA
AtoG
AtoG
AtoC
AtoG
AtoG
AtoG
CtoA
CtoA
CtoG
AtoT
AtoG
AtoT
TtoC
AtoG
GtoC
CtoA
CtoA
GtoA
TtoG
AtoG
CtoG
TtoA
AtoG
GtoA
TtoG
TtoC
AtoT
TtoC
TtoC
AtoG
CtoA
CtoT
TtoC
GtoA
TtoG
TtoC
TtoA
AtoT
TtoC
AtoC
TtoC
CtoT
GtoA
GtoC
GtoA
TtoA
AtoG
GtoT
GtoA
AtoG
AtoG
TtoA
TtoG
TtoG
TtoG
CtoG
TtoG
CtoT
AtoG
TtoC
CtoA
TtoC
TtoG
CtoA
AtoG
CtoA
GtoA
GtoA
GtoA
AtoT
AtoT
GtoC
GtoA
AtoC
AtoC
TtoC
GtoC
AtoT
TtoA
TtoA
AtoG
AtoG
AtoG
TtoC
GtoC
CtoT
AtoC
AtoG
TtoC
TtoC
TtoA
AtoG

0.1053
0.1
0.1579
0.1429
0.1
0.1
0.1
0.1111
0.1
0.1
0.1667
0.7
0.1
0.1
0.1053
0.25
0.1111
0.1
0.1
0.1
0.1
0.1081
0.102
0.1
0.1667
0.9
0.1064
0.1176
0.1
0.1
0.6364
0.1053
0.1
0.1739
0.1818
0.3534
0.1053
0.1053
0.1111
0.1
0.1
0.1
0.1
0.1143
0.2727
0.1579
0.1333
0.1176
0.1818
0.1818
0.1053
0.1
0.1
0.1
0.1111
0.1053
0.1081
0.1
0.2
0.1111
0.1081
0.1176
0.1
0.1429
0.1395
0.1
0.25
0.1034
0.1379
0.1
0.1667
0.3077
0.2857
0.1667
0.1
0.1
0.1
0.1
0.1
0.1
0.3333
0.1111
0.1
0.1053
0.1
0.1
0.1
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1429
0.1

0.2143
0.1071
0.2143
0.1538
0.1333
0.1
0.125
0.1875
0.1304
0.1111
0.2
0.7778
0.125
0.2
0.1818
0.4286
0.2432
0.1818
0.1538
0.4167
0.1667
0.225
0.1429
0.125
0.4211
0.9836
0.1333
0.1538
0.1
0.1818
0.7358
0.1667
0.1176
0.28
0.3684
0.4364
0.32
0.4706
0.12
0.1
0.1
0.15
0.1111
0.1584
0.3
0.3125
0.16
0.2
0.3103
0.1818
0.1538
0.1538
0.1364
0.1667
0.3333
0.2143
0.2174
0.1034
0.5
0.1304
0.2903
0.1429
0.1053
0.1818
0.4
0.1538
0.6
0.2059
0.16
0.3333
0.3636
0.3333
0.4167
0.2143
0.3
0.1
0.1154
0.2
0.1429
0.15
0.6
0.3125
0.1875
0.125
0.2143
0.1538
0.2
0.1667
0.1
0.125
0.1818
0.1053
0.1
0.1875
0.1429
0.1429

3
4
6
6
7
3
2
5
9
4
4
2
6
2
3
3
10
10
4
7
4
10
8
8
11
7
6
4
2
3
2
2
3
3
3
2
11
13
5
2
2
3
3
2
3
2
7
9
2
7
10
17
11
7
10
12
10
11
3
4
15
2
2
5
4
4
3
6
7
2
2
2
2
2
6
4
6
5
2
5
2
12
4
5
2
4
3
4
2
2
3
2
2
11
7
3

2
2
4
2
2
2
2
2
2
2
2
2
2
2
3
3
9
3
2
5
2
7
3
2
6
7
2
2
2
2
2
2
2
2
2
2
11
13
2
2
2
2
3
2
2
2
3
6
2
2
4
4
4
5
6
5
4
3
3
2
8
2
2
2
4
3
2
3
4
2
2
2
2
2
5
2
2
2
2
4
2
12
3
2
2
2
2
3
2
2
2
2
2
5
2
2

[14,19]
[10,28]
[15,22]
[13,14]
[10,16]
[10,10]
[10,16]
[16,18]
[20,23]
[10,10]
[10,12]
[10,10]
[10,16]
[10,10]
[10,19]
[12,17]
[16,52]
[11,20]
[10,13]
[10,15]
[10,12]
[22,40]
[19,52]
[10,16]
[12,41]
[20,67]
[15,47]
[13,17]
[10,10]
[10,11]
[44,53]
[12,19]
[10,17]
[23,25]
[11,19]
[110,116]
[18,36]
[12,31]
[18,25]
[10,10]
[10,11]
[10,20]
[19,66]
[102,105]
[10,11]
[16,19]
[15,25]
[13,25]
[11,29]
[11,12]
[13,26]
[14,36]
[10,23]
[18,42]
[12,30]
[15,29]
[15,40]
[29,59]
[10,36]
[18,24]
[18,67]
[14,17]
[10,19]
[11,21]
[22,66]
[10,26]
[10,21]
[30,76]
[13,29]
[10,18]
[11,12]
[13,15]
[12,14]
[12,14]
[16,22]
[10,10]
[10,27]
[10,11]
[14,44]
[10,20]
[10,18]
[10,31]
[10,27]
[16,19]
[10,14]
[10,13]
[10,10]
[12,16]
[10,10]
[10,16]
[11,20]
[10,19]
[10,10]
[16,90]
[14,15]
[10,14]

TableS10

chr20:2967286
chr1:196970974
chr19:5224570
chr5:159783876
chr5:159787425
chr5:159782437
chr1:31177027
chr2:20374865
chr2:20312081
chr2:20312206
chr2:20313596
chr2:20313870
chr2:20313872
chr7:44890578
chr7:104885495
chr11:119051119
chr12:106630322
chr8:78074783
chr12:119136029
chr12:119134559
chr12:119136337
chr12:119134560
chr1:153200125
chr1:153196741
chr1:153196770
chr12:21493767
chr3:49117170
chr3:49108382
chr4:17103060
chr4:17097609
chr16:29586633
chr16:29586637
chr16:29586863
chr16:29586933
chr16:29587006
chr16:29587023
chr16:29588717
chr3:49045206
chr6:107210183
chr6:107220594
chr9:138239670
chr12:55975509
chr12:55975511
chr8:37851838
chr8:37854031
chr8:37836348
chr8:37837674
chr8:37838228
chr1:152225281
chr1:152221676
chr10:27861495
chr10:27867031
chr2:65178665
chr13:109973868
chr12:70466578
chr20:56369014
chr15:53308160
chr15:53284850
chr4:12992236
chr8:61696010
chr14:20998085
chr18:9850719
chr12:119026056
chr12:119018843
chr11:87486157
chr2:135594882
chr2:135624417
chr2:135643753
chr1:218450777
chr1:218393960
chr1:218389014
chr1:218389369
chr1:218389852
chr16:619125
chr1:227506500
chr3:19994854
chr3:19967313
chr17:37530531
chr3:130015545
chr17:5205371
chr17:5205320
chr17:5182108
chr17:5228442
chr17:5229475
chr9:124906839
chr1:173113155
chr1:173224474
chr7:65911616
chr7:65913423
chr7:65913447
chr7:65913531
chr1:76033272
chr22:35492134
chr7:100745054
chr7:100745057
chr7:6408652

PTPRA
PTPRC
PTPRS
PTTG1
PTTG1
PTTG1
PUM1
PUM2
PUM2
PUM2
PUM2
PUM2
PUM2
PURB
PUS7
PVRL1
PWP1
PXMP3
PXN
PXN
PXN
PXN
PYGO2
PYGO2
PYGO2
PYROXD1
QARS
QARS
QDPR
QDPR
QPRT
QPRT
QPRT
QPRT
QPRT
QPRT
QPRT
QRICH1
QRSL1
QRSL1
QSOX2
R3HDM2
R3HDM2
RAB11FIP1
RAB11FIP1
RAB11FIP1
RAB11FIP1
RAB11FIP1
RAB13
RAB13
RAB18
RAB18
RAB1A
RAB20
RAB21
RAB22A
RAB27A
RAB27A
RAB28
RAB2A
RAB2B
RAB31
RAB35
RAB35
RAB38
RAB3GAP1
RAB3GAP1
RAB3GAP1
RAB3GAP2
RAB3GAP2
RAB3GAP2
RAB3GAP2
RAB3GAP2
RAB40C
RAB4A
RAB5A
RAB5A
RAB5C
RAB7A
RABEP1
RABEP1
RABEP1
RABEP1
RABEP1
RABGAP1
RABGAP1L
RABGAP1L
RABGEF1
RABGEF1
RABGEF1
RABGEF1
RABGGTB
RABL4
RABL5
RABL5
RAC1

UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
coding_exon
coding_exon
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
mixed
mixed
mixed
mixed
mixed
mixed
mixed
coding_exon
coding_exon
UTR3
UTR3
mixed
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR5
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
mixed
mixed
coding_exon
UTR3
UTR3
UTR3
mixed
coding_exon
UTR3
UTR3
UTR3

ENST00000271610:DtoE;ENST00000348564:DtoE;ENST00000352140:DtoE;ENST000
ENST00000262963:GtoR;ENST00000348075:GtoR;ENST00000353284:GtoR;ENST00
ENST00000352433:YtoD;ENST00000393964:YtoD;
ENST00000352433:PtoS;ENST00000393964:PtoS;
ENST00000352433:GtoR;ENST00000393964:GtoR;
ENST00000319801:DtoA;ENST00000338086:DtoA;ENST00000361078:DtoA;ENST00

ENST00000356362:LtoQ;ENST00000469408:LtoQ;

ENST00000228307:RtoQ;ENST00000267257:RtoQ;ENST00000331257:RtoQ;ENST00
ENST00000228307:FtoV;ENST00000267257:FtoV;ENST00000397506:FtoV;ENST000
ENST00000228307:FtoL;ENST00000267257:FtoL;ENST00000331257:FtoL;ENST0000

ENST00000240651:ItoV;
ENST00000306125:MtoL;ENST00000414533:MtoL;ENST00000420147:MtoL;ENST00

ENST00000357496:FtoV;ENST00000395443:FtoV;ENST00000424300:FtoV;
ENST00000369046:GtoA;

ENST00000287263:Yto*;ENST00000330843:Yto*;ENST00000343853:Yto*;
ENST00000287263:StoP;ENST00000330843:StoP;ENST00000343853:StoP;

ENST00000368575:VtoA;
ENST00000368575:FtoL;

ENST00000260638:VtoM;ENST00000398529:VtoM;ENST00000409784:VtoM;

ENST00000288723:VtoL;ENST00000330852:VtoL;ENST00000338176:VtoL;

ENST00000229340:WtoG;ENST00000427416:WtoG;

ENST00000358951:FtoL;

ENST00000273047:StoP;ENST00000422242:StoP;

ENST00000262477:StoP;ENST00000341923:StoP;ENST00000408982:StoP;
ENST00000262477:MtoV;ENST00000341923:MtoV;ENST00000408982:MtoV;
ENST00000262477:DtoG;ENST00000341923:DtoG;ENST00000408982:DtoG;

ENST00000340630:DtoE;ENST00000433985:DtoE;ENST00000453009:DtoE;

111

+
+

+
+
+

+
+
+
+
+
+
+

+
+

+
+

+
+

+
+
+

+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+

TtoA
TtoA
GtoA
TtoG
CtoT
GtoA
TtoC
AtoC
TtoC
AtoG
AtoG
AtoG
TtoC
GtoA
TtoA
CtoG
GtoA
AtoG
GtoA
TtoG
TtoC
CtoA
TtoC
TtoC
TtoG
AtoG
AtoC
TtoG
TtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
TtoG
GtoC
CtoA
AtoC
AtoT
GtoT
CtoA
TtoC
AtoG
TtoC
GtoA
TtoC
TtoC
TtoC
AtoG
GtoA
TtoC
TtoA
AtoG
TtoC
TtoC
GtoC
AtoG
AtoG
AtoG
TtoG
AtoC
TtoC
TtoC
AtoG
TtoA
TtoC
TtoC
TtoC
AtoG
AtoT
TtoA
GtoA
TtoC
TtoC
TtoC
AtoG
TtoC
AtoG
AtoG
GtoA
TtoG
AtoG
GtoA
GtoT
TtoC
TtoA
TtoC
TtoC
AtoT
TtoA
TtoG
TtoG
TtoG

0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.2222
0.1176
0.1333
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1
0.125
0.1333
0.1
0.1
0.1
0.1
0.1364
0.1
0.1538
0.1176
0.1053
0.1053
0.1077
0.1
0.1053
0.1739
0.1538
0.1
0.1
0.1
0.1
0.1
0.125
0.1
0.1053
0.1
0.1
0.1
0.1333
0.1071
0.1
0.1786
0.1333
0.1333
0.1
0.1111
0.1
0.1
0.1429
0.1
0.1
0.1111
0.1
0.1
0.1
0.1053
0.1053
0.1
0.1429
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1034

0.1
0.1111
0.1538
0.1176
0.1538
0.1667
0.2174
0.2
0.25
0.1538
0.3077
0.1429
0.1562
0.1667
0.1667
0.1
0.1333
0.3529
0.1429
0.1667
0.2222
0.2308
0.1429
0.1
0.1053
0.125
0.1
0.1667
0.1053
0.3077
0.1429
0.1875
0.1799
0.1333
0.1765
0.1364
0.359
0.1875
0.1111
0.1429
0.1111
0.1
0.1
0.1333
0.1176
0.1667
0.1
0.1
0.125
0.2308
0.1111
0.1071
0.2
0.1579
0.1818
0.125
0.1176
0.1429
0.1
0.2727
0.1
0.1111
0.125
0.2
0.1176
0.1
0.125
0.125
0.1
0.1538
0.1538
0.1667
0.125
0.2
0.1
0.1
0.1176
0.1
0.1818
0.1667
0.1111
0.1053
0.1
0.2
0.2
0.2
0.1
0.1538
0.1111
0.1429
0.1176
0.1
0.1053
0.1
0.1429
0.1515

5
8
2
7
6
2
10
2
8
5
3
2
7
5
2
3
5
9
6
4
2
5
5
3
4
2
2
13
3
4
4
7
11
8
4
6
16
6
2
4
2
2
2
2
3
3
4
2
3
4
4
3
3
2
3
3
4
4
2
5
3
4
3
3
2
5
2
2
5
2
4
5
3
2
2
3
2
3
4
4
2
3
2
6
7
2
2
5
2
2
2
2
4
2
2
6

2
2
2
2
2
2
7
2
2
2
2
2
2
3
2
2
2
7
3
3
2
3
2
2
2
2
2
2
2
2
2
2
3
2
2
2
16
2
2
3
2
2
2
2
2
2
2
2
2
3
2
3
2
2
2
2
2
2
2
5
2
3
2
3
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3

[10,10]
[10,27]
[10,13]
[17,20]
[13,19]
[12,20]
[13,30]
[10,10]
[12,18]
[13,17]
[13,15]
[14,18]
[10,32]
[10,19]
[10,12]
[10,10]
[10,15]
[10,24]
[10,18]
[12,15]
[10,10]
[13,16]
[15,15]
[10,10]
[10,19]
[10,16]
[10,10]
[20,22]
[10,19]
[13,13]
[14,18]
[16,19]
[35,139]
[15,65]
[10,17]
[19,22]
[36,130]
[13,16]
[18,20]
[10,14]
[10,18]
[10,10]
[10,10]
[15,16]
[10,17]
[12,19]
[10,10]
[10,10]
[10,16]
[13,16]
[18,28]
[10,28]
[10,28]
[15,19]
[11,15]
[10,16]
[10,17]
[10,14]
[10,10]
[11,14]
[10,10]
[10,27]
[16,18]
[10,30]
[10,17]
[10,10]
[19,24]
[16,19]
[10,10]
[13,14]
[13,18]
[10,14]
[10,16]
[10,10]
[10,10]
[10,10]
[10,17]
[10,10]
[11,13]
[18,20]
[10,18]
[10,19]
[10,10]
[10,11]
[10,10]
[10,10]
[10,10]
[13,19]
[10,10]
[14,20]
[10,17]
[10,10]
[10,19]
[10,10]
[11,14]
[30,43]

TableS10

chr3:8898033
chr19:12924913
chr19:12925440
chr9:109132970
chr5:131979610
chr15:38810942
chr17:54129107
chr3:51639855
chr11:66917741
chr11:66920222
chr11:66916827
chr20:55386498
chr3:12600140
chr3:12680550
chr3:12680552
chr1:153377556
chr17:17638680
chr7:39696651
chr7:39702910
chr7:39629729
chr2:120768437
chr9:134963066
chr20:32131723
chr20:32131727
chr12:129926754
chr12:129926756
chr12:129927543
chr16:66319848
chr2:108765620
chr2:108764254
chr19:5868097
chr6:13747834
chr6:13765375
chr22:39982752
chr22:39971567
chr1:112056999
chr1:112057002
chr12:67340559
chr4:99556999
chr4:160498849
chr11:63060920
chr6:88296081
chr5:86705874
chr5:86706472
chr5:86722551
chr5:86722622
chr19:15423456
chr19:15423458
chr15:36591168
chr15:36578360
chr3:50342730
chr20:4710057
chr20:4710395
chr12:63375251
chr19:10288728
chr19:10289099
chr13:47952304
chr13:47952378
chr1:32907434
chr1:203322683
chr1:203322790
chr1:203322821
chr16:24488024
chr16:24488778
chr16:24478381
chr20:18425732
chr20:346449
chr20:359603
chr20:35059082
chr16:52053190
chr16:52082170
chr16:52082171
chr8:94816068
chr8:94815132
chr8:94816007
chr11:66149277
chr1:110689719
chr6:155187140
chr10:6187062
chr10:6197666
chr14:22444164
chr14:22440217
chr14:22440250
chr14:22458065
chr14:72656997
chr14:72657303
chr13:78794485
chr13:78794487
chr13:78792150
chr5:145621406
chr5:145630787
chr7:127740534
chr7:155230562
chr1:233382672
chr20:33790881
chr20:33790882

RAD18
RAD23A
RAD23A
RAD23B
RAD50
RAD51
RAD51C
RAD54L2
RAD9A
RAD9A
RAD9A
RAE1
RAF1
RAF1
RAF1
RAG1AP1
RAI1
RALA
RALA
RALA
RALB
RALGDS
RALY
RALY
RAN
RAN
RAN
RANBP10
RANBP2
RANBP2
RANBP3
RANBP9
RANBP9
RANGAP1
RANGAP1
RAP1A
RAP1A
RAP1B
RAP1GDS1
RAPGEF2
RARRES3
RARS2
RASA1
RASA1
RASA1
RASA1
RASAL3
RASAL3
RASGRP1
RASGRP1
RASSF1
RASSF2
RASSF2
RASSF3
RAVER1
RAVER1
RB1
RB1
RBBP4
RBBP5
RBBP5
RBBP5
RBBP6
RBBP6
RBBP6
RBBP9
RBCK1
RBCK1
RBL1
RBL2
RBL2
RBL2
RBM12B
RBM12B
RBM12B
RBM14
RBM15
RBM16
RBM17
RBM17
RBM23
RBM23
RBM23
RBM23
RBM25
RBM25
RBM26
RBM26
RBM26
RBM27
RBM27
RBM28
RBM33
RBM34
RBM39
RBM39

UTR3
UTR3
UTR3
mixed
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR5
UTR5
UTR3
coding_exon
coding_exon
coding_exon
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR5
UTR3
UTR3
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon

ENST00000265335:LtoR;ENST00000378810:LtoR;ENST00000378823:LtoR;

ENST00000307980:VtoA;
ENST00000307980:RtoT;
ENST00000307980:KtoQ;
ENST00000371242:QtoR;ENST00000395840:QtoR;ENST00000395841:QtoR;

ENST00000261641:StoP;ENST00000315321:StoP;ENST00000353383:StoP;ENST000
ENST00000005257:EtoG;
ENST00000005257:AtoE;

ENST00000317506:ItoV;ENST00000411657:ItoV;ENST00000448631:ItoV;
ENST00000283195:ItoK;ENST00000409491:ItoK;

ENST00000011619:StoG;ENST00000283152:StoG;
ENST00000011619:CtoW;ENST00000283152:CtoW;
ENST00000356244:VtoG;ENST00000405383:VtoG;ENST00000405486:VtoG;ENST00

ENST00000264572:KtoE;ENST00000339360:KtoE;ENST00000380158:KtoE;ENST000
ENST00000255688:AtoS;ENST00000439013:AtoS;
ENST00000369536:LtoP;
ENST00000274376:StoP;ENST00000456692:StoP;
ENST00000274376:StoI;ENST00000456692:StoI;

ENST00000310803:GtoC;ENST00000414708:GtoC;ENST00000415523:GtoC;ENST00

ENST00000319715:YtoH;ENST00000348022:YtoH;
ENST00000319715:RtoK;ENST00000348022:RtoK;
ENST00000337227:VtoG;ENST00000339848:VtoG;

ENST00000262133:NtoK;ENST00000379935:NtoK;

ENST00000329529:RtoW;
ENST00000329529:KtoE;
ENST00000329529:FtoS;
ENST00000310137:QtoK;
ENST00000369784:Kto*;
ENST00000379888:EtoK;ENST00000418869:EtoK;ENST00000446108:EtoK;

ENST00000265271:QtoH;
ENST00000223073:VtoA;ENST00000415472:VtoA;
ENST00000366606:QtoR;ENST00000408888:QtoR;

112

+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+

+
+
+
+
+

+
+

+
+
+
+
+
+

+
+
+
+

+
+
+

+
+
+

+
+

+
+
+

+
+
+
+
+

+
+

+
+

TtoG
AtoG
TtoA
AtoG
TtoG
TtoC
TtoG
TtoC
TtoC
GtoC
AtoC
AtoG
AtoG
AtoG
GtoA
TtoG
TtoC
AtoG
CtoA
TtoG
AtoG
TtoG
TtoC
AtoG
AtoG
TtoA
TtoC
AtoG
TtoA
TtoC
TtoA
AtoG
TtoG
TtoG
AtoG
AtoG
TtoA
TtoG
AtoG
TtoG
GtoT
TtoC
TtoC
GtoT
AtoT
GtoT
TtoA
AtoG
GtoT
TtoC
TtoC
AtoG
GtoT
TtoC
AtoT
TtoA
AtoG
TtoG
AtoG
TtoC
TtoG
TtoC
TtoC
GtoA
AtoG
TtoG
AtoG
TtoC
TtoC
CtoG
GtoA
AtoT
AtoT
AtoG
TtoC
CtoA
AtoT
AtoC
GtoA
TtoC
TtoG
CtoG
GtoT
TtoG
TtoC
TtoC
AtoG
GtoC
TtoC
AtoC
GtoA
TtoC
GtoA
AtoG
CtoT
GtoA

0.1
0.1
0.1111
0.1
0.1
0.125
0.1333
0.1
0.1
0.1
0.1429
0.1
0.15
0.1
0.1176
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.125
0.1667
0.1034
0.1176
0.1
0.1
0.1
0.1
0.1
0.1429
0.1
0.1
0.1
0.1053
0.1333
0.1111
0.1
0.1
0.1
0.1
0.1538
0.1
0.1
0.1
0.1053
0.1429
0.1
0.1
0.1071
0.1
0.1176
0.1333
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.1111
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1667
0.1
0.1
0.1034
0.1
0.1053
0.1071
0.1042
0.1
0.1053
0.1111
0.1
0.1111
0.1
0.1
0.1111
0.1111
0.1304
0.1053
0.1667
0.1667

0.1538
0.25
0.1538
0.1538
0.1
0.1429
0.1538
0.1
0.1
0.1429
0.2
0.1429
0.25
0.1176
0.15
0.2
0.1333
0.1111
0.1538
0.1
0.3
0.1
0.1538
0.4
0.12
0.4286
0.1875
0.1111
0.1
0.1304
0.1818
0.16
0.1538
0.1905
0.3077
0.25
0.1905
0.2
0.3
0.1
0.1
0.1667
0.1818
0.2
0.1
0.1
0.1818
0.1923
0.125
0.125
0.1176
0.125
0.1176
0.2
0.3077
0.1333
0.125
0.125
0.1429
0.1429
0.1
0.2
0.1333
0.1818
0.1
0.1053
0.1
0.25
0.1
0.1
0.1429
0.2632
0.15
0.1
0.1
0.1923
0.1
0.2308
0.1404
0.1667
0.1111
0.3529
0.3077
0.1
0.1053
0.1818
0.1429
0.1818
0.1
0.125
0.1333
0.2
0.1667
0.1429
0.3
0.3

6
2
4
3
9
4
5
3
2
9
4
3
6
3
3
2
2
2
6
2
2
2
12
4
10
18
3
2
4
3
2
4
4
6
5
3
5
5
2
2
3
2
3
2
3
2
3
6
4
3
4
2
5
3
4
6
4
4
4
3
4
3
2
2
2
3
2
6
3
2
5
5
4
3
2
3
2
2
10
5
3
11
16
2
7
7
7
6
3
3
3
5
3
8
4
4

3
2
3
2
2
2
3
3
2
2
3
2
2
2
2
2
2
2
4
2
2
2
3
3
2
16
2
2
2
2
2
2
2
3
5
2
2
3
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
3
2
3
2
2
2
2
2
3
2
5
11
2
2
2
3
2
2
2
2
2
2
2
3
3

[10,13]
[10,17]
[10,14]
[10,13]
[10,10]
[15,16]
[15,29]
[10,10]
[10,10]
[10,14]
[10,14]
[10,14]
[12,20]
[10,17]
[17,20]
[10,10]
[10,15]
[18,20]
[13,24]
[10,10]
[10,10]
[10,11]
[13,20]
[10,12]
[26,30]
[11,38]
[10,16]
[10,18]
[10,30]
[10,23]
[10,11]
[14,25]
[10,13]
[15,21]
[10,19]
[12,19]
[15,22]
[10,18]
[10,10]
[10,10]
[10,10]
[10,12]
[11,13]
[10,10]
[10,10]
[10,10]
[11,19]
[22,28]
[10,17]
[10,16]
[17,28]
[10,16]
[17,18]
[10,15]
[13,20]
[16,16]
[10,16]
[10,16]
[10,21]
[10,14]
[10,10]
[10,10]
[15,15]
[10,11]
[10,10]
[10,19]
[10,20]
[12,30]
[10,10]
[10,10]
[19,21]
[10,20]
[10,20]
[10,10]
[10,10]
[12,26]
[10,10]
[10,14]
[57,58]
[10,20]
[18,19]
[17,56]
[13,58]
[10,10]
[19,20]
[10,11]
[10,21]
[11,18]
[10,10]
[10,16]
[15,18]
[10,18]
[12,23]
[14,19]
[10,12]
[10,12]

TableS10

chr20:33791863
chr20:33791902
chr11:66164064
chr11:66170391
chr4:40121625
chr3:50102837
chr3:50073981
chr3:50089652
chr4:26039552
chr4:26026243
chr4:25973299
chr4:26045636
chr9:124646784
chr13:47962103
chr1:28709382
chr15:89305852
chr4:76626437
chr9:4850142
chr15:75015106
chr1:209552871
chr1:209544071
chr1:209555760
chr1:165940916
chr1:165940918
chr1:165941778
chr14:67213866
chr14:67213868
chr11:109609337
chr14:23719088
chr14:23712384
chr14:23718481
chr14:23716243
chr14:23716255
chr12:21545477
chr12:21545510
chr12:21545662
chr8:145707516
chr17:71137150
chr17:71137149
chr10:65040033
chr11:72785333
chr11:72785334
chr7:149697696
chr6:139306737
chr6:139283047
chr6:139304192
chr1:8337709
chr4:57490953
chr2:85422843
chr2:85422845
chr2:99387535
chr2:99384163
chr9:135261857
chr4:39029482
chr4:38982876
chr4:38994963
chr4:38965698
chr4:38966417
chr4:38966664
chr12:116953656
chr12:116953864
chr17:30361198
chr3:53100898
chr3:16332361
chr3:16332422
chr1:174316958
chr1:174420447
chr16:73212858
chr16:73214533
chr19:13933566
chr15:54170541
chr3:102766812
chr1:182147948
chr1:182161906
chr6:33367920
chr6:33369204
chr6:33372812
chr9:35744075
chr1:190815484
chr1:190815488
chr1:190815671
chr10:121249447
chr1:180834437
chr1:180834726
chr1:180835941
chr20:62175086
chr20:62181092
chr1:191044930
chr2:227568551
chr2:227569287
chr7:150795122
chr12:47745404
chr12:47745441
chr3:49371592
chr8:22931788
chr1:113045277

RBM39
RBM39
RBM4
RBM4
RBM47
RBM5
RBM6
RBM6
RBPSUH
RBPSUH
RBPSUH
RBPSUH
RC3H2
RCBTB2
RCC1
RCCD1
RCHY1
RCL1
RCN2
RCOR3
RCOR3
RCOR3
RCSD1
RCSD1
RCSD1
RDH11
RDH11
RDX
REC8
REC8
REC8
REC8
REC8
RECQL
RECQL
RECQL
RECQL4
RECQL5
RECQL5
REEP3
RELT
RELT
REPIN1
REPS1
REPS1
REPS1
RERE
REST
RETSAT
RETSAT
REV1
REV1
REXO4
RFC1
RFC1
RFC1
RFC1
RFC1
RFC1
RFC5
RFC5
RFFL
RFT1
RFTN1
RFTN1
RFWD2
RFWD2
RFWD3
RFWD3
RFX1
RFX7
RG9MTD1
RGL1
RGL1
RGL2
RGL2
RGL2
RGP1
RGS1
RGS1
RGS1
RGS10
RGS16
RGS16
RGS16
RGS19
RGS19
RGS2
RHBDD1
RHBDD1
RHEB
RHEBL1
RHEBL1
RHOA
RHOBTB2
RHOC

coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR5
coding_exon
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
UTR5
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
UTR5
UTR5
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR5
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
UTR3
UTR3
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
coding_exon
UTR3
UTR3
UTR3
mixed
mixed
UTR3
UTR3
UTR3

ENST00000342295:LtoH;ENST00000342320:LtoH;ENST00000345843:LtoH;ENST000

ENST00000300233:GtoV;ENST00000394258:GtoV;
ENST00000381728:HtoR;ENST00000381730:HtoR;ENST00000381750:HtoR;ENST00
ENST00000367005:EtoA;ENST00000419091:EtoA;ENST00000435653:EtoA;ENST000

ENST00000311457:QtoK;ENST00000447460:QtoK;
ENST00000311457:LtoQ;ENST00000447460:LtoQ;
ENST00000311457:ItoV;ENST00000447460:ItoV;

ENST00000317905:LtoV;
ENST00000317905:LtoP;

ENST00000258062:YtoN;ENST00000367663:YtoN;ENST00000367668:YtoN;ENST00
ENST00000258062:VtoA;ENST00000367663:VtoA;ENST00000367668:VtoA;ENST00
ENST00000258062:KtoE;ENST00000367663:KtoE;ENST00000367668:KtoE;ENST000
ENST00000309042:CtoF;ENST00000358605:CtoF;

ENST00000258428:LtoP;ENST00000393445:LtoP;

ENST00000349703:KtoE;ENST00000381897:KtoE;
ENST00000349703:ItoT;ENST00000381897:ItoT;

ENST00000309922:LtoR;
ENST00000304685:StoP;ENST00000360851:StoP;ENST00000367531:StoP;
ENST00000304685:StoC;ENST00000360851:StoC;ENST00000367531:StoC;
ENST00000421215:EtoA;

ENST00000235382:TtoP;

113

+
+

+
+
+
+
+
+
+

+
+

+
+
+
+
+
+
+
+

+
+
+
+
+

+
+
+
+

+
+

+
+
+

+
+
+
+

+
+
+

AtoC
AtoG
TtoC
TtoG
AtoG
CtoT
CtoG
TtoA
TtoA
GtoA
CtoA
TtoA
AtoC
GtoC
TtoC
GtoT
AtoG
AtoG
GtoA
AtoC
TtoC
GtoA
AtoG
TtoC
TtoC
TtoC
TtoC
AtoC
CtoA
TtoA
AtoG
AtoG
TtoA
CtoA
AtoT
TtoG
TtoG
CtoG
TtoC
AtoG
CtoA
TtoA
AtoC
TtoA
TtoC
AtoG
GtoC
GtoT
AtoG
TtoG
TtoC
TtoG
AtoG
AtoG
TtoC
TtoC
TtoA
TtoG
TtoA
TtoA
AtoG
TtoC
AtoG
CtoA
AtoC
AtoG
AtoG
TtoA
TtoC
AtoG
CtoT
TtoG
TtoC
AtoT
AtoC
TtoG
GtoT
AtoG
TtoC
AtoG
TtoA
TtoG
AtoG
TtoC
CtoA
AtoG
TtoA
AtoC
TtoA
TtoC
CtoT
AtoG
TtoC
AtoG
TtoC
AtoG

0.1765
0.1111
0.1143
0.1111
0.1
0.1
0.2
0.1
0.1
0.1
0.1
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.125
0.1
0.1053
0.1
0.1176
0.1
0.1373
0.1
0.1111
0.1
0.3333
0.1
0.1
0.1111
0.1
0.1667
0.1
0.1
0.1
0.1
0.1
0.1
0.1538
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1667
0.1
0.1
0.1
0.1
0.1
0.1
0.1667
0.1
0.1
0.1029
0.1429
0.125
0.1538
0.1026
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.2
0.1176
0.1146
0.1071
0.1
0.1429
0.1
0.1
0.1
0.1
0.1
0.9667
0.1
0.1
0.1667
0.1
0.1

0.4
0.1429
0.1944
0.15
0.1
0.125
0.3333
0.1
0.1053
0.1579
0.1538
0.2105
0.1667
0.1
0.1429
0.125
0.1
0.1429
0.1
0.1
0.1
0.1818
0.5714
0.4286
0.125
0.2632
0.1818
0.1667
0.2
0.1765
0.1304
0.2
0.5
0.1
0.1
0.2308
0.1
0.25
0.1818
0.1
0.1
0.2222
0.1818
0.1
0.1667
0.1818
0.1111
0.1
0.1429
0.1765
0.125
0.1
0.1
0.1
0.1818
0.1
0.1818
0.1429
0.1176
0.1
0.2
0.1765
0.1818
0.2
0.1528
0.1538
0.125
0.2
0.1905
0.1
0.1
0.1667
0.1
0.1
0.1
0.125
0.1
0.1667
0.129
0.2105
0.1667
0.1154
0.125
0.1053
0.1818
0.1818
0.125
0.1
0.1111
0.1429
1
0.1667
0.1538
0.25
0.1667
0.2857

4
3
8
8
3
3
3
2
2
4
2
2
2
2
3
2
3
4
2
2
2
2
4
3
11
7
10
4
4
2
4
2
3
2
5
2
5
4
2
2
2
5
2
3
5
5
3
2
4
8
3
2
2
4
2
5
2
2
4
4
3
3
3
9
5
8
2
2
6
2
4
4
2
2
2
2
2
2
7
16
10
10
3
5
6
4
2
2
2
7
17
2
2
4
5
6

3
2
3
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
3
3
5
4
2
3
2
2
2
2
3
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
3
2
2
2
3
2
2
2
2
2
2
2
2
2
5
3
2
2
2
3
2
3
2
2
2
2
2
2
2
3
2
2
2
2
2
3
2
2
2
2
2
17
2
2
4
3
5

[10,17]
[14,18]
[17,70]
[18,40]
[10,10]
[10,16]
[10,21]
[10,22]
[10,19]
[10,19]
[10,13]
[10,19]
[12,15]
[10,30]
[10,16]
[10,16]
[10,10]
[10,14]
[10,10]
[10,10]
[10,10]
[10,11]
[14,24]
[14,24]
[19,36]
[13,20]
[11,18]
[10,17]
[25,51]
[10,17]
[24,27]
[10,10]
[10,16]
[10,10]
[10,10]
[10,13]
[10,10]
[12,16]
[10,11]
[10,10]
[10,10]
[10,10]
[10,11]
[10,10]
[12,13]
[19,22]
[10,18]
[10,10]
[10,14]
[10,18]
[10,16]
[10,10]
[20,30]
[10,10]
[11,12]
[10,10]
[10,11]
[10,14]
[10,17]
[10,11]
[10,10]
[12,17]
[10,11]
[10,16]
[72,136]
[14,14]
[16,16]
[13,15]
[15,39]
[10,10]
[10,10]
[10,12]
[10,10]
[10,10]
[10,10]
[11,16]
[10,10]
[10,12]
[17,31]
[10,20]
[12,17]
[27,102]
[16,28]
[10,19]
[12,14]
[10,11]
[10,16]
[10,11]
[10,10]
[10,14]
[32,61]
[10,12]
[13,20]
[10,16]
[11,14]
[10,14]

TableS10

chr1:113045280
chr11:3804790
chr11:3804794
chr4:39922176
chr2:46656889
chr2:46657244
chr2:46656827
chr2:46623828
chr2:46656774
chr2:46656828
chr17:27527103
chr17:27526465
chr17:27576504
chr16:661000
chr16:660999
chr16:664135
chr11:205073
chr2:152029058
chr2:152034482
chr1:42653052
chr5:96538748
chr5:96528974
chr18:19311144
chr18:19311143
chr18:19298040
chr18:19315455
chr18:19315985
chr8:90871727
chr1:154136661
chr6:151796000
chr2:86852259
chr5:31445181
chr5:31562752
chr6:167272246
chr12:119482921
chr12:119499165
chr20:48002833
chr20:48003503
chr1:144398437
chr11:71383533
chr19:598871
chr5:141338332
chr5:141343255
chr5:141343159
chr5:141333490
chr5:158517130
chr2:101276911
chr17:4788761
chr3:197699951
chr11:74225412
chr2:85678216
chr2:85678215
chr22:29913229
chr22:29913036
chr8:101338885
chr8:101339083
chr8:101339372
chr1:183328838
chr1:183328830
chr1:183323332
chr1:183327334
chr1:183327390
chr1:183327446
chr1:183327381
chr9:103337640
chr9:103365412
chr17:75934795
chr17:75972086
chr7:5629239
chr7:5747445
chr7:5628718
chr13:78088393
chr1:44874470
chr2:219237062
chr11:118713207
chr14:23686898
chr14:23699696
chr12:120338508
chr9:36328592
chr9:36329353
chr16:30693883
chr16:30693974
chr12:54886482
chr3:142947235
chr6:37457058
chr6:37436229
chr6:37444708
chr6:89671197
chr6:89377239
chr11:494825
chr18:13754208
chr17:642180
chr1:200241832
chr2:241166521
chr16:2254575
chr16:2243294

RHOC
RHOG
RHOG
RHOH
RHOQ
RHOQ
RHOQ
RHOQ
RHOQ
RHOQ
RHOT1
RHOT1
RHOT1
RHOT2
RHOT2
RHOT2
RIC8A
RIF1
RIF1
RIMKLA
RIOK2
RIOK2
RIOK3
RIOK3
RIOK3
RIOK3
RIOK3
RIPK2
RIT1
RMND1
RMND5A
RNASEN
RNASEN
RNASET2
RNF10
RNF10
RNF114
RNF114
RNF115
RNF121
RNF126
RNF14
RNF14
RNF14
RNF14
RNF145
RNF149
RNF167
RNF168
RNF169
RNF181
RNF181
RNF185
RNF185
RNF19A
RNF19A
RNF19A
RNF2
RNF2
RNF2
RNF2
RNF2
RNF2
RNF2
RNF20
RNF20
RNF213
RNF213
RNF216
RNF216
RNF216
RNF219
RNF220
RNF25
RNF26
RNF31
RNF31
RNF34
RNF38
RNF38
RNF40
RNF40
RNF41
RNF7
RNF8
RNF8
RNF8
RNGTT
RNGTT
RNH1
RNMT
RNMTL1
RNPEP
RNPEPL1
RNPS1
RNPS1

UTR3
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
UTR5
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
mixed
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR5
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3

ENST00000238738:TtoA;
ENST00000238738:NtoS;
ENST00000238738:KtoR;
ENST00000238738:AtoT;

ENST00000333942:ItoV;ENST00000354266:ItoV;ENST00000358365:ItoV;ENST0000
ENST00000333942:DtoN;ENST00000354266:DtoN;ENST00000358365:DtoN;ENST00
ENST00000315082:DtoE;
ENST00000315082:DtoA;

ENST00000283109:ItoT;
ENST00000339486:WtoR;ENST00000424813:WtoR;ENST00000453294:WtoR;

ENST00000220751:EtoG;

ENST00000283632:QtoP;
ENST00000265075:LtoQ;ENST00000344624:LtoQ;ENST00000442743:LtoQ;
ENST00000310843:YtoC;
ENST00000325954:HtoP;ENST00000413266:HtoP;ENST00000458409:HtoP;

ENST00000369291:WtoR;
ENST00000361756:StoP;
ENST00000347642:NtoS;ENST00000356143:NtoS;ENST00000394514:NtoS;ENST000
ENST00000347642:LtoQ;ENST00000356143:LtoQ;ENST00000394514:LtoQ;ENST000
ENST00000347642:LtoP;ENST00000356143:LtoP;ENST00000394514:LtoP;ENST0000

ENST00000262482:HtoP;ENST00000381350:HtoP;
ENST00000318037:AtoG;
ENST00000299563:GtoR;

ENST00000266252:VtoA;ENST00000326132:VtoA;ENST00000419966:VtoA;ENST00

ENST00000367510:RtoW;
ENST00000367510:PtoL;
ENST00000367509:NtoK;ENST00000367510:NtoK;
ENST00000367509:EtoK;ENST00000367510:EtoK;
ENST00000367509:EtoD;ENST00000367510:EtoD;
ENST00000367509:CtoS;ENST00000367510:CtoS;

ENST00000336301:ItoV;
ENST00000447067:HtoP;

ENST00000282003:Kto*;

ENST00000324103:MtoL;ENST00000382682:MtoL;
ENST00000354795:GtoE;ENST00000361234:GtoE;ENST00000392465:GtoE;

ENST00000373479:LtoP;

ENST00000265607:StoA;ENST00000369475:StoA;ENST00000369485:StoA;

ENST00000320225:RtoM;ENST00000397086:RtoM;

114

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+

+
+
+
+
+
+

+
+
+
+

+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+

+
+
+
+

+
+

+
+
+
+

+
+
+
+

TtoC
TtoC
TtoA
GtoA
AtoG
AtoG
AtoG
GtoA
TtoC
AtoG
AtoG
GtoA
GtoA
TtoA
AtoC
TtoA
AtoG
AtoG
TtoC
TtoC
TtoC
TtoA
TtoA
CtoG
GtoA
TtoA
TtoA
AtoG
AtoG
AtoG
AtoC
TtoA
AtoG
AtoG
AtoC
TtoC
TtoC
AtoG
TtoA
TtoC
GtoC
AtoG
TtoA
TtoC
CtoT
GtoT
AtoG
AtoC
CtoG
GtoA
CtoA
CtoA
TtoC
TtoC
TtoC
TtoC
TtoG
CtoT
CtoT
CtoA
GtoA
AtoT
GtoC
AtoG
AtoG
TtoC
AtoG
CtoA
AtoC
TtoC
AtoG
AtoT
GtoC
TtoC
GtoA
AtoC
AtoG
GtoA
AtoG
TtoG
TtoG
TtoG
TtoC
CtoA
TtoC
AtoG
AtoG
TtoG
TtoA
AtoG
AtoG
TtoA
AtoG
AtoG
GtoT
AtoG

0.1667
0.1176
0.15
0.1
0.1
0.1
0.125
0.1111
0.1667
0.1429
0.3571
0.1818
0.1111
0.1143
0.129
0.1053
0.15
0.1
0.1
0.1
0.1
0.1111
0.1111
0.1081
0.1
0.1
0.125
0.1
0.1
0.125
0.1
0.1053
0.1
0.2
0.15
0.1
0.1053
0.1053
0.1034
0.1
0.1
0.1538
0.1333
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.8
0.3571
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1818
0.1071
0.1
0.1
0.1
0.1
0.1
0.1
0.1
1
0.1667
0.1053
0.1
0.1
0.1087
0.1111
0.1
0.1
0.1
0.1
0.1
0.1429
0.1
0.1111
0.1
0.1111
0.1
0.119
0.1017
0.1389

0.2917
0.1364
0.1667
0.1053
0.2
0.2
0.1818
0.1154
0.2857
0.1667
0.8182
0.9091
0.125
0.2
0.2381
0.1538
0.1538
0.1053
0.1
0.1111
0.1
0.2
0.1429
0.1667
0.1
0.1579
0.1818
0.1667
0.1818
0.1333
0.1
0.1538
0.1
0.4
0.1905
0.1
0.1111
0.1176
0.2
0.2143
0.12
0.1667
0.1429
0.1111
0.25
0.1053
0.1
0.1613
0.1
0.1
0.9
0.6429
0.1
0.1111
0.1429
0.1
0.125
0.1667
0.2
0.2
0.1
0.2632
0.1667
0.3
0.1
0.125
0.2
0.1333
0.2222
0.1
0.1579
0.1
0.1
0.1
0.1
1
0.25
0.125
0.2
0.1429
0.25
0.1818
0.1818
0.7
0.2
0.125
0.1
0.1818
0.1429
0.1212
0.1364
0.1111
0.15
0.122
0.2698
0.1429

6
6
3
2
11
9
4
4
5
5
4
5
4
5
5
5
5
2
5
2
2
7
6
7
3
5
8
7
5
4
3
5
2
4
5
2
7
5
8
9
2
6
3
2
2
3
2
6
4
2
3
12
5
3
9
5
5
2
2
3
2
5
6
6
2
3
3
2
8
5
4
2
2
2
2
6
5
2
2
2
7
2
3
2
2
2
2
4
4
3
10
5
3
2
18
11

6
2
2
2
3
6
4
2
4
4
4
5
2
2
2
2
2
2
2
2
2
2
4
6
2
2
2
2
2
2
2
2
2
3
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
3
12
2
2
3
2
2
2
2
3
2
3
3
5
2
2
2
2
6
2
2
2
2
2
2
6
2
2
2
2
6
2
2
2
2
2
2
2
2
2
3
2
2
2
12
3

[12,149]
[17,22]
[12,20]
[10,19]
[16,20]
[10,23]
[11,26]
[26,27]
[10,14]
[12,26]
[11,15]
[10,15]
[16,18]
[25,35]
[21,31]
[13,20]
[13,20]
[10,19]
[10,10]
[18,20]
[10,10]
[10,18]
[14,36]
[12,56]
[10,20]
[10,19]
[11,16]
[12,40]
[10,11]
[15,16]
[10,10]
[14,19]
[10,10]
[10,11]
[20,21]
[10,10]
[19,27]
[17,19]
[21,51]
[10,14]
[10,25]
[12,13]
[14,15]
[10,18]
[10,12]
[10,19]
[10,10]
[31,36]
[10,10]
[10,10]
[10,11]
[10,25]
[10,10]
[10,18]
[10,27]
[10,10]
[10,16]
[10,12]
[10,10]
[10,14]
[10,10]
[10,19]
[10,12]
[10,20]
[10,10]
[10,24]
[11,15]
[15,28]
[10,37]
[10,10]
[10,19]
[10,10]
[10,10]
[10,10]
[10,10]
[13,33]
[12,18]
[16,20]
[10,10]
[10,14]
[12,46]
[11,18]
[10,12]
[10,11]
[10,10]
[10,16]
[10,20]
[11,14]
[10,14]
[33,54]
[10,22]
[10,36]
[10,20]
[42,42]
[32,73]
[23,49]

TableS10

chr1:154294917
chr3:78729988
chr18:16818446
chr18:16849401
chr2:11240651
chr9:114025989
chr9:114026264
chr9:114021089
chr1:152947273
chr10:13679499
chr10:13692142
chr9:114273771
chr11:17206620
chr11:17206626
chr11:17206627
chr11:17206663
chr11:17206672
chr11:17206673
chr10:103328649
chr9:5978482
chr3:52554606
chr22:48990776
chr22:48989119
chr20:36484294
chr1:87101270
chr20:33328542
chr20:33328566
chr20:33330138
chr20:33330143
chr1:32414560
chr20:61663214
chr20:51617571
chr20:51617829
chr20:32331737
chr20:5512968
chr16:87332577
chr7:33105449
chr7:33105467
chr7:33105565
chr7:33105498
chr7:33105520
chr7:33105550
chr7:7642914
chr7:7642920
chr17:5270015
chr15:39597542
chr15:39616112
chr15:39610627
chr12:46349047
chr2:210589490
chr6:35545273
chr6:35546351
chr6:35546357
chr6:35544769
chr6:35546456
chr6:35546447
chr6:35546096
chr6:35546373
chr6:35545281
chr6:35545270
chr6:35545282
chr6:35545269
chr6:35545940
chr6:35545976
chr6:35545278
chr6:35545949
chr6:35546458
chr6:35545957
chr6:35546459
chr6:35544432
chr6:35544553
chr6:35544937
chr6:35545941
chr6:35545947
chr6:35546349
chr6:35546355
chr6:35546457
chr6:35546534
chr1:23891687
chr1:23891686
chr1:23891684
chr1:23891685
chr1:23895501
chr9:129252841
chr9:129250509
chr9:129250469
chr9:129252851
chr9:129251783
chr9:129250464
chr9:129250465
chr9:129250477
chr9:129251397
chr9:129251767
chr9:129252840
chr9:129249774
chr9:129249775

ROBLD3
ROBO1
ROCK1
ROCK1
ROCK2
ROD1
ROD1
ROD1
RP11274N19.1
RP11295P9.1
RP11295P9.1
RP1132M23.1
RP11452G18.1
RP11452G18.1
RP11452G18.1
RP11452G18.1
RP11452G18.1
RP11452G18.1
RP11529I10.1
RP11546N22.1
RP11844E22.1
RP3402G11.1
RP3402G11.1
RP4564F22.1
RP4604K5.1
RP4614O4.1
RP4614O4.1
RP4614O4.1
RP4614O4.1
RP4622L5.1
RP4697K14.1
RP4724E16.1
RP4724E16.1
RP4785G19.1
RP51022P6.1
RP51142A6.1
RP9
RP9
RP9
RP9
RP9
RP9
RPA3
RPA3
RPAIN
RPAP1
RPAP1
RPAP1
RPAP3
RPE
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL10A
RPL11
RPL11
RPL11
RPL11
RPL11
RPL12
RPL12
RPL12
RPL12
RPL12
RPL12
RPL12
RPL12
RPL12
RPL12
RPL12
RPL12
RPL12

UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
mixed
UTR3
mixed
mixed
mixed
mixed
mixed
coding_exon
mixed
mixed
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3

ENST00000399799:LtoV;
ENST00000399799:LtoM;
ENST00000343327:HtoR;ENST00000374255:HtoR;ENST00000374257:HtoR;ENST00
ENST00000343327:GtoV;ENST00000374255:GtoV;ENST00000374257:GtoV;ENST00

ENST00000380903:CtoG;ENST00000400016:CtoG;

ENST00000252889:StoP;ENST00000427522:StoP;ENST00000467148:StoP;

ENST00000297157:MtoK;
ENST00000297157:GtoE;
ENST00000297157:EtoD;
ENST00000297157:AtoT;

ENST00000381208:EtoG;ENST00000381209:EtoG;ENST00000405578:EtoG;
ENST00000304330:VtoG;
ENST00000304330:VtoA;
ENST00000304330:StoT;

ENST00000322203:VtoG;
ENST00000322203:VtoE;
ENST00000322203:VtoD;
ENST00000322203:StoP;
ENST00000322203:RtoQ;
ENST00000322203:QtoR;
ENST00000322203:QtoP;
ENST00000322203:MtoI;
ENST00000322203:LtoV;
ENST00000322203:LtoP;
ENST00000322203:LtoP;
ENST00000322203:LtoM;
ENST00000322203:KtoR;
ENST00000322203:KtoM;
ENST00000322203:KtoE;
ENST00000322203:AtoV;
ENST00000322203:AtoT;
ENST00000322203:AtoS;
ENST00000322203:AtoD;

ENST00000374550:QtoP;
ENST00000374550:QtoE;

ENST00000361436:PtoH;
ENST00000361436:NtoD;
ENST00000361436:MtoT;
ENST00000361436:KtoE;
ENST00000361436:ItoS;
ENST00000361436:HtoD;

115

+
+

+
+
+
+
+
+
+

+
+
+

+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

TtoA
AtoG
TtoG
TtoA
AtoG
AtoG
GtoT
AtoG
AtoC
CtoA
AtoG
AtoT
GtoC
GtoC
GtoT
TtoA
AtoT
TtoA
AtoT
GtoA
TtoC
TtoG
TtoC
GtoT
TtoG
TtoC
TtoA
GtoA
TtoC
TtoC
TtoC
AtoC
AtoG
GtoA
AtoG
AtoC
TtoA
GtoA
GtoC
GtoA
CtoT
TtoC
TtoA
TtoC
AtoG
TtoG
TtoC
TtoA
AtoG
CtoA
TtoG
TtoA
TtoA
TtoC
GtoA
AtoG
AtoC
GtoC
CtoG
TtoC
TtoC
CtoA
AtoG
AtoT
AtoG
CtoT
GtoA
GtoT
CtoA
AtoG
GtoT
AtoG
GtoA
TtoC
TtoA
TtoA
GtoA
TtoA
AtoC
CtoG
AtoT
GtoT
AtoG
CtoA
AtoG
TtoC
AtoG
TtoG
CtoG
GtoA
TtoC
AtoG
TtoG
CtoG
AtoG
GtoA

0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1273
0.1
0.1
0.1
0.1
0.1
0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1081
0.1818
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1364
0.1667
0.1
0.1111
0.1333
0.1
0.2308
0.125
0.125
0.125
0.1
0.1
0.1333
0.1053
0.125
0.125
0.2941
0.1009
0.1364
0.1277
0.1327
0.1
0.1176
0.1111
0.1111
0.125
0.1111
0.1212
0.1667
0.125
0.1
0.1053
0.2308
0.1
0.1176
0.1
0.1
0.125
0.1304
0.1176
0.125
0.8
0.1005
0.104
0.619
0.1
0.1
0.1667
0.1084
0.1119
0.1429
0.1026
0.1101
0.1105
0.1011
0.1007
0.1333
0.1163
0.1818
0.1034

0.2
0.1818
0.1333
0.1538
0.1818
0.1
0.1
0.1515
0.1667
0.1
0.1538
0.125
0.1351
0.1333
0.3
0.1538
0.1818
0.2
0.1053
0.1
0.1
0.1429
0.1053
0.1
0.1667
0.1111
0.1429
0.4
0.35
0.1
0.1818
0.1
0.2
0.1538
0.125
0.1
0.2258
0.2963
0.65
0.125
0.6154
0.825
0.2941
0.2
0.1579
0.1333
0.2143
0.1
0.1667
0.1111
0.2
0.4
0.7778
0.1616
0.1429
0.1842
0.1413
0.1538
0.1667
0.2
0.4737
0.1935
0.1333
0.1944
0.1818
0.2222
0.3636
0.1176
0.3684
0.1
0.1818
0.1333
0.2667
0.1765
0.3846
0.3333
0.3571
0.9412
0.1115
0.1706
0.8
0.2143
0.3846
0.2609
0.1593
0.1566
0.1739
0.1029
0.1824
0.1799
0.1754
0.1272
0.1351
0.2838
0.4
0.4167

3
2
4
3
2
3
4
11
3
3
4
4
4
2
3
3
5
6
4
3
5
3
2
2
6
4
5
2
11
2
2
5
2
4
3
3
3
6
8
5
12
8
2
5
9
2
2
2
2
5
7
12
7
18
8
10
10
6
5
6
8
6
7
8
2
16
9
3
6
2
5
3
11
5
14
7
13
8
17
17
3
4
21
4
17
11
4
4
13
12
16
21
11
6
7
16

3
2
2
2
2
2
2
4
3
2
2
2
2
2
2
2
3
5
2
2
2
2
2
2
2
2
2
2
8
2
2
2
2
2
2
2
2
2
6
2
7
8
2
2
3
2
2
2
2
2
2
12
7
11
3
4
2
2
2
3
2
4
2
3
2
6
8
2
5
2
4
2
7
2
14
6
12
8
3
3
3
4
21
3
3
7
3
2
7
5
9
7
2
4
4
12

[10,11]
[10,11]
[10,15]
[10,13]
[10,11]
[10,20]
[10,10]
[35,77]
[18,55]
[10,10]
[10,13]
[10,16]
[10,38]
[10,16]
[10,13]
[13,31]
[10,11]
[10,12]
[10,19]
[10,10]
[10,10]
[10,14]
[10,19]
[10,10]
[12,18]
[10,10]
[14,37]
[10,12]
[13,35]
[10,10]
[10,11]
[10,10]
[10,11]
[10,26]
[16,30]
[10,10]
[22,31]
[18,27]
[10,27]
[16,18]
[15,28]
[10,40]
[13,17]
[10,16]
[19,40]
[15,24]
[10,15]
[10,10]
[12,15]
[18,19]
[11,16]
[10,84]
[10,40]
[99,233]
[14,23]
[22,47]
[97,102]
[10,13]
[13,17]
[10,16]
[10,19]
[13,31]
[15,18]
[45,72]
[11,13]
[15,54]
[12,53]
[17,19]
[14,23]
[10,10]
[11,17]
[10,15]
[10,32]
[17,18]
[10,98]
[15,47]
[10,32]
[10,27]
[260,487]
[211,441]
[10,21]
[10,23]
[12,76]
[43,70]
[173,391]
[64,172]
[78,121]
[68,157]
[45,289]
[43,265]
[58,418]
[97,216]
[32,38]
[43,76]
[12,16]
[14,365]

TableS10

chr9:129249776
chr9:129249777
chr9:129253492
chr9:129253493
chr9:129253495
chr16:88156977
chr16:88157877
chr16:88157879
chr19:54686524
chr19:54686148
chr19:54682699
chr19:54682701
chr19:54685363
chr19:54685365
chr19:54685333
chr19:54682702
chr19:54685294
chr19:54685299
chr19:54686115
chr19:54686529
chr19:54687356
chr19:54687358
chr19:54687359
chr19:54682677
chr19:54682689
chr19:54682691
chr19:54682692
chr19:54682693
chr19:54682698
chr13:53912812
chr13:53912816
chr12:6863341
chr12:6863804
chr3:40474421
chr3:40477958
chr3:40474416
chr3:40477970
chr3:40478441
chr3:40477969
chr3:40475194
chr3:40475195
chr3:40478156
chr3:40475200
chr3:40478111
chr3:40478148
chr3:40478445
chr3:40478107
chr3:40478106
chr3:40477962
chr3:40477968
chr3:40478476
chr3:40478567
chr3:40478670
chr3:40478690
chr3:40478840
chr12:61645723
chr12:61645721
chr3:23933626
chr18:45271796
chr18:45271908
chr18:45271790
chr18:45271178
chr18:45271785
chr18:45271177
chr18:45270877
chr18:45271294
chr18:45271293
chr18:45270836
chr18:45270826
chr18:45270884
chr18:45271180
chr18:45271198
chr18:45271199
chr18:45271782
chr18:45270841
chr18:45270840
chr18:45271168
chr18:45270875
chr18:45270832
chr18:45270825
chr18:45270879
chr18:45271170
chr18:45271179
chr18:45271182
chr18:45271197
chr18:45272833
chr18:45272835
chr18:45272837
chr19:53810958
chr19:53810960
chr19:17835121
chr19:17831735
chr17:34612810
chr17:34612840
chr17:34612101
chr17:34612846

RPL12
RPL12
RPL12
RPL12
RPL12
RPL13
RPL13
RPL13
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13A
RPL13AP22
RPL13AP22
RPL13P5
RPL13P5
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14
RPL14P1
RPL14P1
RPL15
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL17P20
RPL18
RPL18
RPL18A
RPL18A
RPL19P12
RPL19P12
RPL19P12
RPL19P12

UTR3
UTR3
UTR5
UTR5
UTR5
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR5
UTR5
UTR5
UTR5
UTR5
UTR5
UTR3
UTR3
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
UTR3
coding_exon
coding_exon
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
UTR5
UTR5
coding_exon
coding_exon
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon

ENST00000391857:VtoI;
ENST00000391857:RtoC;
ENST00000391857:MtoL;
ENST00000391857:MtoI;
ENST00000391857:KtoQ;
ENST00000391857:KtoN;
ENST00000391857:ItoV;
ENST00000391857:AtoS;

ENST00000338970:YtoN;ENST00000396203:YtoN;ENST00000416518:YtoN;
ENST00000338970:Wto*;ENST00000396203:Wto*;ENST00000416518:Wto*;
ENST00000338970:VtoG;ENST00000396203:VtoG;ENST00000416518:VtoG;
ENST00000338970:RtoQ;ENST00000396203:RtoQ;ENST00000416518:RtoQ;
ENST00000338970:RtoK;ENST00000396203:RtoK;
ENST00000338970:RtoG;ENST00000396203:RtoG;ENST00000416518:RtoG;
ENST00000338970:MtoV;ENST00000396203:MtoV;ENST00000416518:MtoV;
ENST00000338970:MtoR;ENST00000396203:MtoR;ENST00000416518:MtoR;
ENST00000338970:MtoI;ENST00000396203:MtoI;ENST00000416518:MtoI;
ENST00000338970:LtoI;ENST00000396203:LtoI;ENST00000416518:LtoI;
ENST00000338970:KtoN;ENST00000396203:KtoN;ENST00000416518:KtoN;
ENST00000338970:KtoE;ENST00000396203:KtoE;ENST00000416518:KtoE;
ENST00000338970:ItoM;ENST00000396203:ItoM;ENST00000416518:NtoD;
ENST00000338970:AtoV;ENST00000396203:AtoV;ENST00000416518:AtoV;
ENST00000338970:AtoT;ENST00000396203:AtoT;ENST00000416518:AtoT;

ENST00000266610:TtoS;
ENST00000266610:KtoR;
ENST00000418495:StoP;ENST00000441578:StoP;
ENST00000418495:PtoL;ENST00000441578:PtoL;
ENST00000418495:LtoI;ENST00000441578:LtoI;
ENST00000332968:VtoF;ENST00000418495:VtoF;ENST00000441578:VtoF;
ENST00000332968:VtoE;
ENST00000332968:VtoA;ENST00000418495:VtoA;ENST00000441578:VtoA;
ENST00000332968:StoI;ENST00000418495:StoI;ENST00000441578:StoI;
ENST00000332968:NtoS;ENST00000418495:NtoS;ENST00000441578:NtoS;
ENST00000332968:NtoK;ENST00000418495:NtoK;ENST00000441578:NtoK;
ENST00000332968:NtoD;ENST00000418495:NtoD;ENST00000441578:NtoD;
ENST00000332968:LtoH;ENST00000418495:LtoH;ENST00000441578:LtoH;
ENST00000332968:KtoQ;ENST00000418495:KtoQ;ENST00000441578:KtoQ;
ENST00000332968:GtoA;ENST00000418495:GtoA;ENST00000441578:GtoA;
ENST00000332968:FtoS;ENST00000418495:FtoS;ENST00000441578:FtoS;
ENST00000332968:FtoL;ENST00000418495:FtoL;ENST00000441578:FtoL;
ENST00000332968:FtoC;
ENST00000332968:EtoG;ENST00000418495:EtoG;ENST00000441578:EtoG;
ENST00000332968:EtoD;ENST00000418495:EtoD;ENST00000441578:EtoD;
ENST00000332968:CtoS;ENST00000418495:CtoS;ENST00000441578:CtoS;
ENST00000332968:AtoS;ENST00000418495:AtoS;ENST00000441578:AtoS;
ENST00000332968:AtoD;ENST00000418495:AtoD;ENST00000441578:AtoD;

ENST00000084795:HtoP;

ENST00000225430:VtoA;
ENST00000225430:RtoH;
ENST00000225430:QtoK;
ENST00000225430:LtoQ;

116

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+

GtoA
TtoA
GtoT
GtoC
TtoG
TtoC
AtoG
AtoG
GtoA
CtoT
AtoC
GtoC
AtoC
GtoT
AtoG
GtoT
CtoT
AtoG
CtoA
CtoA
AtoG
AtoG
TtoA
CtoT
GtoT
TtoC
GtoC
CtoT
GtoT
AtoG
TtoC
CtoG
TtoC
TtoA
GtoA
TtoG
GtoA
GtoA
CtoG
AtoG
TtoG
GtoA
CtoA
GtoT
AtoG
AtoG
CtoT
GtoA
AtoG
AtoG
GtoA
CtoA
TtoC
AtoG
AtoG
AtoT
AtoG
TtoG
TtoC
CtoT
CtoA
GtoT
TtoA
TtoC
GtoT
AtoG
CtoA
AtoG
TtoA
AtoC
GtoC
TtoC
TtoC
TtoG
AtoG
GtoT
GtoC
GtoT
CtoA
TtoG
GtoA
GtoA
AtoT
TtoG
CtoT
AtoT
GtoT
AtoC
AtoC
GtoC
CtoA
TtoC
TtoC
GtoA
CtoA
TtoA

0.101
0.1477
0.1296
0.102
0.1111
0.1002
0.1
0.1333
0.1
0.2308
0.1
0.1287
0.1039
0.1111
0.1067
0.1171
0.2
0.1818
0.1
0.1
0.1098
0.1176
0.1053
0.125
0.1333
0.1154
0.1176
0.1538
0.1132
0.1875
0.1667
0.1
0.1
0.1667
0.1
0.3
0.2222
0.1
0.5
0.1
0.1667
0.1
0.1
0.1765
0.1
0.1
0.4
0.2
0.1034
0.1538
0.1
0.1364
0.1525
0.1818
0.1765
1
1
0.2105
0.1111
0.12
0.1053
0.1111
0.1
0.1111
0.1053
0.1
0.6
0.1
0.1
0.1429
0.1
0.4444
0.1
0.1333
0.1
0.1
0.1228
0.1
0.1
0.2
0.1316
0.1231
0.1039
0.1111
0.2308
0.1111
0.1
0.1429
0.1122
0.1126
0.1127
0.12
0.1068
0.1
0.1522
0.1031

0.4118
0.3962
0.2128
0.1951
0.1667
0.1471
0.2353
0.1333
0.2727
0.2667
0.1765
0.4286
0.1481
0.175
0.1366
0.44
0.5
0.8571
0.2308
0.1667
0.1429
0.1875
0.2609
0.2
0.3077
0.1875
0.6098
0.55
0.1739
0.3043
0.1935
0.1667
0.1
0.1667
0.2093
0.6
0.8182
0.1
0.6923
0.1667
0.2143
0.1667
0.1212
0.1818
0.1333
0.1
0.9
0.9091
0.125
0.1765
0.3
0.2083
0.2308
0.5
0.3
1
1
0.6364
0.1667
0.28
0.1538
0.413
0.1176
0.4444
0.3788
0.7692
0.7692
0.1
0.2308
0.2308
0.2069
0.9091
0.1
0.1429
0.1538
0.3571
0.125
0.1429
0.15
0.2667
0.1707
0.1299
0.2143
0.2222
0.7273
0.1944
0.1818
0.48
0.229
0.138
0.1158
0.4667
0.2121
0.2045
0.1538
0.1053

18
9
8
7
3
19
8
3
7
5
11
13
6
10
18
12
6
8
3
6
6
13
4
4
4
5
12
10
10
2
2
2
2
4
12
7
6
6
3
6
5
11
2
5
7
5
3
3
6
6
3
3
6
7
4
2
2
2
4
9
5
16
2
15
10
4
3
4
3
11
11
6
3
4
3
11
5
8
3
3
8
4
14
8
8
8
9
14
7
4
12
9
11
8
5
11

16
9
3
5
2
9
4
2
4
2
8
12
3
4
7
12
6
8
3
3
3
7
3
4
2
2
8
6
5
2
2
2
2
2
10
4
6
2
3
3
2
4
2
2
2
2
3
3
2
2
3
2
2
6
2
2
2
2
2
5
2
13
2
14
8
4
3
2
3
2
6
6
2
2
3
7
2
2
2
2
3
2
9
2
8
2
4
8
4
3
2
9
7
5
2
2

[64,499]
[70,1092]
[47,54]
[28,52]
[18,25]
[544,1204]
[10,17]
[15,15]
[10,21]
[14,15]
[13,127]
[19,160]
[27,97]
[19,124]
[230,745]
[21,180]
[12,30]
[11,25]
[10,15]
[10,13]
[35,84]
[16,56]
[15,23]
[10,24]
[13,15]
[16,27]
[11,43]
[14,40]
[18,116]
[23,50]
[30,62]
[10,18]
[10,10]
[13,13]
[17,53]
[11,26]
[10,14]
[20,20]
[13,14]
[10,13]
[14,18]
[10,34]
[10,33]
[11,17]
[16,22]
[10,20]
[10,14]
[11,13]
[16,29]
[13,18]
[10,12]
[66,170]
[27,62]
[10,16]
[10,17]
[10,11]
[11,12]
[11,19]
[13,18]
[26,92]
[13,19]
[36,108]
[10,17]
[19,115]
[25,68]
[10,29]
[10,30]
[10,10]
[10,13]
[21,42]
[22,75]
[10,14]
[10,10]
[14,15]
[10,27]
[10,24]
[56,171]
[21,36]
[10,20]
[10,15]
[37,41]
[66,179]
[29,77]
[18,19]
[10,14]
[37,54]
[10,34]
[11,42]
[2198,4164]
[2740,4456]
[97,147]
[15,68]
[204,409]
[136,316]
[47,52]
[106,139]

TableS10

chr17:34613944
chr17:34612105
chr17:34613861
chr17:34613921
chr17:34613941
chr17:34611017
chr17:34612165
chr17:34612163
chr17:34612841
chr17:34612862
chr17:34612880
chr17:34613859
chr17:34613961
chr17:34613962
chr17:34614432
chr17:34614453
chr17:34614502
chr13:26728452
chr13:26728451
chr13:26728453
chr13:26728443
chr13:26728442
chr13:26728447
chr13:26728693
chr13:26728697
chr13:26728698
chr13:26728699
chr13:26728701
chr3:172066770
chr17:34259432
chr17:34259865
chr17:34259866
chr17:34259867
chr17:34259877
chr17:34263508
chr17:34263515
chr17:24071154
chr17:24074760
chr17:24074753
chr17:24074747
chr17:24074748
chr17:24072035
chr17:24073975
chr17:24074757
chr17:24074750
chr17:24073968
chr17:24071888
chr17:24071889
chr17:24072036
chr17:24072037
chr17:24072038
chr17:24074737
chr17:24074758
chr17:24075080
chr17:24075082
chr17:24075190
chr17:24075466
chr17:24071146
chr3:102882658
chr3:102888248
chr3:102888252
chr17:8223894
chr17:8221665
chr17:8226270
chr17:8221699
chr17:8226269
chr17:8221670
chr17:8221587
chr17:8221565
chr17:38405507
chr17:38405491
chr17:38408458
chr17:38408469
chr11:8663963
chr11:8664819
chr11:8665283
chr11:8660914
chr11:8660915
chr19:60590467
chr19:60590466
chr19:60591554
chr19:60591555
chr19:60591556
chr19:60591557
chr19:60591558
chr19:60591559
chr19:60595049
chr3:52004092
chr3:52003061
chr3:52003815
chr3:52002684
chr3:52004945
chr3:52004946
chr22:38038834
chr22:38038847
chr22:38038848

RPL19P12
RPL19P12
RPL19P12
RPL19P12
RPL19P12
RPL19P12
RPL19P12
RPL19P12
RPL19P12
RPL19P12
RPL19P12
RPL19P12
RPL19P12
RPL19P12
RPL19P12
RPL19P12
RPL19P12
RPL21
RPL21
RPL21
RPL21
RPL21
RPL21
RPL21
RPL21
RPL21
RPL21
RPL21
RPL22L1
RPL23
RPL23
RPL23
RPL23
RPL23
RPL23
RPL23
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL23A
RPL24
RPL24
RPL24
RPL26
RPL26
RPL26
RPL26
RPL26
RPL26
RPL26
RPL26
RPL27
RPL27
RPL27
RPL27
RPL27A
RPL27A
RPL27A
RPL27A
RPL27A
RPL28
RPL28
RPL28
RPL28
RPL28
RPL28
RPL28
RPL28
RPL28
RPL29
RPL29
RPL29
RPL29
RPL29
RPL29
RPL3
RPL3
RPL3

coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
mixed
mixed
mixed
mixed
UTR5
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR5
UTR3
UTR5
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR5
UTR5
coding_exon
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR5
UTR5
UTR3
UTR3
UTR3

ENST00000225430:KtoE;
ENST00000225430:ItoT;
ENST00000225430:HtoP;
ENST00000225430:HtoP;
ENST00000225430:DtoN;
ENST00000225430:AtoP;
ENST00000225430:AtoD;

ENST00000272274:WtoS;ENST00000311549:WtoS;ENST00000319826:WtoS;ENST0
ENST00000272274:WtoG;ENST00000311549:WtoG;ENST00000319826:WtoG;ENST
ENST00000272274:WtoC;ENST00000311549:WtoC;ENST00000319826:WtoC;ENST0
ENST00000272274:KtoT;ENST00000311549:KtoT;ENST00000319826:KtoT;ENST000
ENST00000272274:Kto*;ENST00000311549:Kto*;ENST00000319826:Kto*;ENST000

ENST00000422514:AtoS;
ENST00000394935:YtoF;ENST00000394938:YtoF;ENST00000422514:YtoF;
ENST00000394935:PtoA;ENST00000394938:PtoA;ENST00000422514:PtoA;
ENST00000394935:LtoV;ENST00000394938:LtoV;ENST00000422514:LtoV;
ENST00000394935:LtoQ;ENST00000394938:LtoQ;ENST00000422514:LtoQ;
ENST00000394935:KtoR;ENST00000394938:KtoR;ENST00000422514:KtoR;
ENST00000394935:KtoR;ENST00000394938:KtoR;ENST00000422514:KtoR;
ENST00000394935:DtoV;ENST00000394938:DtoV;ENST00000422514:DtoV;
ENST00000394935:AtoT;ENST00000394938:AtoT;ENST00000422514:AtoT;
ENST00000394935:AtoS;ENST00000394938:AtoS;ENST00000422514:AtoS;
ENST00000394935:AtoD;ENST00000394938:AtoD;ENST00000422514:AtoD;

ENST00000293842:VtoA;ENST00000334048:VtoA;
ENST00000293842:QtoR;ENST00000334048:QtoR;
ENST00000293842:KtoN;ENST00000334048:KtoN;
ENST00000293842:KtoE;ENST00000334048:KtoE;
ENST00000293842:ItoL;ENST00000334048:ItoL;

ENST00000253788:YtoS;
ENST00000253788:TtoP;
ENST00000253788:FtoI;

ENST00000428193:*toR;

ENST00000481629:StoR;
ENST00000294189:LtoR;ENST00000466397:LtoR;ENST00000475248:LtoR;ENST000

117

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

AtoG
TtoC
AtoC
AtoC
GtoA
GtoC
CtoA
GtoA
CtoG
TtoC
TtoC
TtoC
CtoT
CtoT
TtoC
TtoC
TtoC
GtoC
TtoG
GtoT
AtoC
AtoT
TtoC
TtoC
CtoA
TtoG
AtoG
AtoG
AtoG
TtoG
TtoA
TtoA
AtoG
AtoC
CtoT
CtoT
GtoT
AtoT
CtoG
CtoG
TtoA
AtoG
AtoG
AtoT
GtoA
GtoT
CtoA
TtoG
GtoA
TtoA
CtoG
AtoG
TtoC
TtoA
TtoA
AtoC
AtoG
AtoG
TtoC
CtoT
CtoT
TtoC
AtoG
GtoT
AtoG
AtoC
TtoC
TtoG
GtoA
AtoC
AtoC
TtoA
TtoG
TtoA
AtoG
CtoA
CtoT
CtoT
TtoA
GtoA
CtoA
CtoA
TtoA
GtoA
CtoA
CtoA
CtoT
TtoA
TtoG
TtoA
AtoG
CtoT
CtoG
CtoA
TtoG
TtoA

0.1429
0.102
0.1125
0.1316
0.1667
0.1667
0.1714
0.2222
0.1452
0.1111
0.15
0.102
0.1
0.1176
0.1106
0.101
0.1042
0.1111
0.125
0.125
0.1
0.1
0.1333
0.1029
0.1111
0.1071
0.1
0.1667
0.1176
0.1
0.1538
0.5484
0.1379
0.4324
0.125
0.1
0.1111
0.1667
0.1
0.1273
0.2143
0.1818
0.1
0.1538
0.1667
0.1111
0.1765
0.125
0.1667
0.2
0.2
0.1077
0.1333
0.1
0.12
0.1111
0.1429
0.1304
0.1008
0.1
0.1
0.1092
0.1013
0.1111
0.105
0.1008
0.1192
0.102
0.1111
0.1246
0.1157
0.121
0.1
0.1143
0.1
0.1
0.125
0.1429
0.3
0.1538
0.1333
0.1087
0.1765
0.1429
0.1429
0.3
0.1
0.1
0.1151
0.1
0.1053
0.12
0.1111
0.8
0.1044
0.1004

0.6117
0.1176
0.3566
0.1408
0.1852
0.2212
0.4783
0.5714
0.241
0.1636
0.1538
0.1695
0.25
0.2857
0.1586
0.2
0.1714
0.5
0.1538
0.4062
0.1538
0.1
0.1538
0.1149
0.1458
0.4286
0.125
0.1818
0.1364
0.1
0.5
0.75
0.2899
0.9833
0.1321
0.2222
0.2857
0.3
0.6429
0.2857
0.8182
0.7
0.1081
0.2
0.7
0.2632
0.275
0.25
0.6364
0.4545
0.5
0.1549
0.2
0.2619
0.1765
0.1429
0.2692
0.1538
0.1148
0.3158
0.2143
0.2415
0.1417
0.2963
0.1886
0.3026
0.3607
0.1581
0.3125
0.1723
0.1241
0.1552
0.15
0.2444
0.1333
0.1
0.1714
0.1667
0.8182
0.3529
0.1364
0.15
0.7273
0.45
0.3636
0.3571
0.1
0.1333
0.1395
0.1
0.2556
0.1429
0.1786
0.9714
0.1534
0.1602

15
12
9
6
4
3
11
10
7
9
5
3
4
7
3
12
10
19
11
20
7
6
12
17
8
10
7
9
6
3
3
6
7
14
7
12
6
3
2
15
16
7
6
2
12
8
7
3
9
7
6
9
2
13
8
10
7
9
7
13
5
14
12
11
18
12
15
16
16
3
4
10
3
13
3
3
4
4
2
5
7
6
10
10
9
3
2
5
7
2
17
8
10
10
7
6

14
3
5
2
2
2
11
9
4
3
2
2
4
5
2
11
2
17
2
18
2
3
4
2
4
9
3
2
2
2
3
6
6
14
2
8
5
2
2
12
15
7
2
2
11
5
6
2
9
6
6
2
2
10
2
4
2
2
2
10
3
6
2
6
18
7
15
10
4
2
2
3
2
8
2
2
2
3
2
4
2
4
10
8
6
3
2
3
2
2
16
2
4
10
4
4

[11,105]
[17,49]
[81,270]
[39,72]
[12,27]
[106,139]
[19,106]
[17,74]
[130,302]
[29,177]
[41,53]
[62,105]
[10,17]
[11,17]
[210,899]
[131,380]
[35,48]
[15,67]
[13,16]
[14,65]
[10,13]
[10,10]
[13,15]
[175,352]
[18,48]
[14,36]
[16,28]
[11,12]
[17,22]
[10,10]
[13,14]
[13,34]
[26,86]
[60,399]
[17,54]
[28,60]
[14,23]
[10,13]
[10,14]
[31,187]
[19,113]
[10,14]
[20,37]
[10,13]
[15,72]
[13,19]
[10,42]
[12,32]
[10,13]
[10,12]
[10,12]
[67,77]
[10,15]
[20,131]
[17,25]
[49,108]
[14,26]
[13,23]
[241,246]
[10,33]
[10,18]
[177,599]
[81,128]
[54,158]
[319,981]
[78,183]
[151,533]
[135,537]
[16,28]
[330,568]
[122,309]
[63,130]
[10,21]
[35,455]
[10,15]
[10,10]
[17,35]
[18,42]
[10,11]
[13,29]
[15,22]
[14,56]
[11,53]
[12,37]
[10,22]
[10,14]
[10,10]
[10,15]
[143,295]
[10,10]
[39,131]
[25,30]
[16,62]
[16,54]
[177,640]
[173,628]

TableS10

chr8:99123159
chr8:99123160
chr8:99123161
chr8:99123164
chr8:99126936
chr8:99126937
chr8:99126946
chr2:100985182
chr2:100985194
chr3:12852681
chr3:12852705
chr3:12852706
chr3:12852708
chr3:12852658
chr3:12852711
chr3:12852680
chr3:12852713
chr3:12858010
chr3:12858011
chr3:12858014
chr3:12858029
chr4:109770628
chr4:109770629
chr4:109761188
chr4:109761201
chr4:109761202
chr9:126660050
chr9:126659983
chr9:126659987
chr19:5642670
chr5:40870339
chr5:40870345
chr5:40870349
chr5:40868316
chr5:40868340
chr5:40871072
chr2:217072985
chr2:217093742
chr2:217074404
chr2:217074406
chr2:217074422
chr2:217074423
chr2:217074431
chr2:217074436
chr2:217074483
chr2:217074689
chr2:217071810
chr2:217071812
chr2:217071816
chr2:217071820
chr17:69717585
chr17:69717588
chr17:69711412
chr17:69711418
chr17:69711420
chr3:188321745
chr15:64578706
chr15:64578708
chr15:64578709
chr15:64578710
chr15:64578711
chr15:64578720
chr12:54797262
chr12:54797261
chr12:54797533
chr1:93070187
chr1:93070191
chr1:93070201
chr1:93070202
chr1:93080065
chr1:93080066
chr1:93080067
chr1:93080068
chr12:111328215
chr12:111328142
chr12:111330798
chr12:111328128
chr12:111328141
chr12:111328180
chr12:111330683
chr12:111330680
chr12:111330794
chr12:111330792
chr12:111328127
chr12:111330682
chr12:111330793
chr12:111331780
chr12:111331781
chr12:111331793
chr12:111331795
chr8:74366036
chr8:74365993
chr8:74367101
chr8:74367110
chr8:74367143
chr8:74367188

RPL30
RPL30
RPL30
RPL30
RPL30
RPL30
RPL30
RPL31
RPL31
RPL32
RPL32
RPL32
RPL32
RPL32
RPL32
RPL32
RPL32
RPL32
RPL32
RPL32
RPL32
RPL34
RPL34
RPL34
RPL34
RPL34
RPL35
RPL35
RPL35
RPL36
RPL37
RPL37
RPL37
RPL37
RPL37
RPL37
RPL37A
RPL37A
RPL37A
RPL37A
RPL37A
RPL37A
RPL37A
RPL37A
RPL37A
RPL37A
RPL37A
RPL37A
RPL37A
RPL37A
RPL38
RPL38
RPL38
RPL38
RPL38
RPL39L
RPL4
RPL4
RPL4
RPL4
RPL4
RPL4
RPL41
RPL41
RPL41
RPL5
RPL5
RPL5
RPL5
RPL5
RPL5
RPL5
RPL5
RPL6P10
RPL6P10
RPL6P10
RPL6P10
RPL6P10
RPL6P10
RPL6P10
RPL6P10
RPL6P10
RPL6P10
RPL6P10
RPL6P10
RPL6P10
RPL6P10
RPL6P10
RPL6P10
RPL6P10
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7

UTR3
UTR3
UTR3
UTR3
UTR5
UTR5
UTR5
UTR5
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
UTR5
UTR5
UTR5
UTR3
UTR3
UTR5
UTR5
UTR5
coding_exon
mixed
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR5
coding_exon
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR5
UTR5
UTR5
UTR5
UTR3
UTR3
UTR5
UTR5
UTR5
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
UTR5
UTR5
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon

ENST00000273223:NtoT;ENST00000396953:NtoT;ENST00000396957:NtoT;ENST00
ENST00000273223:ItoT;ENST00000396953:ItoT;ENST00000396957:ItoT;ENST00000
ENST00000273223:ItoL;ENST00000396953:ItoL;ENST00000396957:ItoL;ENST00000
ENST00000273223:EtoG;ENST00000396953:EtoG;ENST00000396957:EtoG;ENST000
ENST00000273223:AtoS;ENST00000396953:AtoS;ENST00000396957:AtoS;ENST000
ENST00000273223:AtoD;ENST00000396953:AtoD;ENST00000396957:AtoD;ENST00

ENST00000348462:YtoD;

ENST00000274242:KtoQ;
ENST00000274242:KtoQ;

ENST00000414721:RtoK;
ENST00000414721:RtoG;

ENST00000202773:VtoA;ENST00000424576:VtoA;
ENST00000202773:StoR;ENST00000424576:StoR;
ENST00000202773:PtoS;ENST00000424576:PtoS;
ENST00000202773:PtoR;ENST00000424576:PtoR;
ENST00000202773:NtoD;ENST00000424576:NtoD;
ENST00000202773:KtoE;ENST00000424576:KtoE;
ENST00000202773:ItoT;ENST00000424576:ItoT;
ENST00000202773:GtoV;ENST00000424576:GtoV;
ENST00000202773:EtoG;ENST00000424576:EtoG;
ENST00000202773:AtoT;ENST00000424576:AtoT;

ENST00000352983:YtoH;ENST00000396465:YtoH;ENST00000396466:YtoH;ENST000
ENST00000352983:TtoN;ENST00000396465:TtoN;ENST00000396466:TtoN;ENST00
ENST00000352983:RtoG;ENST00000396465:RtoG;ENST00000396466:RtoG;ENST00
ENST00000352983:Rto*;ENST00000396465:Rto*;ENST00000396466:Rto*;ENST000
ENST00000352983:KtoQ;ENST00000396465:KtoQ;ENST00000396466:KtoQ;ENST00
ENST00000352983:KtoE;ENST00000396465:KtoE;ENST00000396466:KtoE;ENST000

118

+
+

+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+

AtoG
AtoG
AtoG
TtoC
CtoT
CtoT
TtoC
TtoC
AtoT
AtoC
TtoC
AtoC
AtoG
GtoT
CtoA
CtoT
TtoC
GtoT
GtoC
GtoT
GtoT
CtoA
CtoA
CtoG
TtoC
GtoT
TtoG
AtoG
TtoA
TtoG
AtoC
AtoC
TtoC
TtoA
AtoG
TtoG
TtoG
GtoA
CtoG
AtoG
TtoA
TtoG
CtoA
TtoA
GtoC
AtoG
TtoG
CtoT
CtoG
GtoT
TtoA
AtoG
CtoT
CtoT
TtoG
TtoC
CtoA
GtoA
TtoA
AtoG
CtoA
AtoG
GtoA
AtoG
GtoA
TtoC
CtoT
AtoC
GtoT
AtoG
AtoG
CtoA
TtoA
TtoC
CtoA
CtoT
CtoG
AtoG
AtoG
TtoC
GtoT
AtoG
GtoA
AtoG
TtoC
AtoG
TtoC
CtoT
TtoG
AtoC
TtoC
CtoA
AtoG
CtoT
AtoC
AtoG

0.1053
0.1
0.129
0.1006
0.12
0.1154
0.1
0.1538
0.125
0.1
0.1
0.1818
0.1667
0.1014
0.1154
0.1192
0.1
0.1136
0.1111
0.1017
0.1
0.1
0.1
0.1087
0.1059
0.1203
0.1008
0.1034
0.1007
0.1197
0.1244
0.1526
0.1005
0.1333
0.1667
0.16
0.1324
0.1429
0.1111
0.1087
0.1
0.1
0.1
0.125
0.1
0.1724
0.1538
0.1
0.1081
0.1613
0.1
0.1176
0.1
0.1
0.1
0.1667
0.1154
0.125
0.1071
0.1154
0.1081
0.1062
0.1
0.1186
0.1282
0.1
0.1
0.1
0.1429
0.1067
0.1017
0.1217
0.9565
0.1111
0.1053
0.1
0.1
0.1538
0.1053
0.2667
0.2353
0.1111
0.1333
0.2222
0.2
0.1053
0.1333
0.1212
0.1111
0.1333
0.1081
0.1
0.1053
0.1
0.1667
0.1

0.3333
0.359
0.216
0.1216
0.1818
0.129
0.1176
0.1538
0.1702
0.1489
0.1667
0.5
0.6
0.1046
0.1176
0.1887
0.1667
0.2083
0.1786
0.1739
0.12
0.375
0.1667
0.1111
0.1606
0.1387
0.1139
0.1356
0.1519
0.1211
0.1416
0.1883
0.2245
0.1667
0.2979
0.4545
0.1645
0.25
0.1273
0.2143
0.1765
0.1667
0.2
0.1364
0.1053
0.3684
0.1667
0.2222
0.1429
0.5517
0.1176
0.2222
0.3125
0.1765
0.1875
0.2143
0.5
0.1818
0.2308
0.1429
0.1786
0.1429
0.3333
0.1818
0.3077
0.1
0.2
0.3208
0.2254
0.25
0.2727
0.5263
1
0.1429
0.3846
0.1071
0.1818
0.3125
0.1818
0.4
0.8182
0.2222
0.7273
0.4444
0.2857
0.7143
0.4545
0.4706
0.2
0.3333
0.1333
0.2
0.25
0.2353
0.2353
0.1

7
10
5
13
8
5
9
2
6
13
5
4
5
11
4
9
14
8
7
4
4
16
8
4
12
8
12
15
14
12
10
4
14
3
20
3
8
2
21
12
8
9
7
5
2
5
3
7
5
13
12
12
13
9
9
5
12
10
12
12
14
15
9
7
4
3
6
8
6
17
15
12
4
8
10
8
2
14
2
3
8
6
9
4
4
11
14
13
7
10
7
3
14
7
6
4

6
10
5
2
3
2
3
2
2
7
3
4
4
3
2
3
4
6
6
3
2
15
4
2
6
2
3
6
13
2
2
3
5
2
20
3
3
2
3
6
3
2
4
2
2
3
2
3
2
13
5
2
9
3
6
2
11
4
9
4
7
4
7
3
4
2
4
5
3
13
4
12
4
4
9
3
2
11
2
3
8
3
9
3
4
11
12
13
3
8
3
2
9
2
4
3

[10,19]
[19,42]
[100,166]
[532,647]
[11,51]
[27,31]
[10,17]
[13,13]
[49,73]
[75,223]
[10,13]
[12,22]
[10,12]
[138,363]
[17,27]
[108,257]
[10,29]
[11,107]
[30,93]
[23,59]
[10,26]
[10,30]
[10,18]
[27,46]
[170,661]
[578,756]
[1454,5000]
[61,184]
[190,778]
[120,272]
[365,672]
[372,728]
[605,1367]
[12,15]
[80,802]
[12,26]
[3593,5785]
[12,14]
[55,130]
[20,135]
[10,17]
[10,18]
[15,49]
[16,23]
[10,19]
[16,29]
[12,13]
[17,20]
[30,37]
[32,132]
[11,35]
[10,18]
[10,48]
[17,30]
[20,104]
[12,15]
[10,26]
[11,28]
[10,37]
[14,60]
[22,38]
[124,343]
[10,34]
[11,62]
[13,39]
[10,10]
[10,33]
[24,72]
[31,71]
[36,211]
[23,60]
[11,118]
[10,25]
[14,18]
[13,31]
[19,28]
[10,12]
[10,30]
[11,19]
[10,15]
[10,21]
[20,20]
[10,30]
[10,22]
[10,15]
[12,36]
[11,33]
[13,33]
[15,18]
[11,20]
[15,37]
[10,11]
[13,31]
[17,20]
[11,17]
[10,11]

TableS10

chr8:74366006
chr8:74365987
chr8:74367095
chr8:74366353
chr8:74365986
chr8:74366007
chr8:74367093
chr8:74367102
chr8:74367484
chr8:74367485
chr8:74367495
chr8:74367507
chr8:74367534
chr8:74367535
chr8:74367545
chr8:74367556
chr8:74365438
chr8:74365440
chr8:74368419
chr8:74368422
chr9:135206617
chr9:135206293
chr9:135206606
chr9:135206611
chr9:135206928
chr9:135207313
chr9:135206930
chr9:135206280
chr9:135207295
chr9:135206279
chr9:135206953
chr9:135206954
chr9:135206300
chr9:135206610
chr9:135207245
chr9:135207246
chr9:135207676
chr9:135208006
chr9:135208009
chr9:135205687
chr9:135205695
chr9:135205704
chr9:135205705
chr9:135205706
chr9:135205708
chr9:135205711
chr9:135205712
chr9:135206222
chr9:135206225
chr9:135206250
chr9:135208075
chr9:135208076
chr9:135208096
chr9:135204908
chr9:135204914
chr6:42959248
chr6:42959280
chr6:42960335
chr8:145985959
chr8:145985960
chr4:39132150
chr4:39132151
chr4:39136913
chr4:39136914
chr4:39136926
chr12:119119095
chr12:119119099
chr12:119120799
chr12:119119539
chr12:119119540
chr12:119119094
chr12:119119097
chr12:119119103
chr12:119119553
chr12:119119556
chr12:119118906
chr12:119118907
chr12:119118912
chr12:119118916
chr12:119118917
chr12:119118931
chr12:119118942
chr12:119118943
chr15:67534883
chr15:67534933
chr15:67534934
chr15:67534940
chr15:67532218
chr11:802873
chr11:802874
chr11:799963
chr11:799968
chr3:129821566
chr3:129821777
chr3:58277310
chr18:31827254

RPL7
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7A
RPL7L1
RPL7L1
RPL7L1
RPL8
RPL8
RPL9
RPL9
RPL9
RPL9
RPL9
RPLP0P3
RPLP0P3
RPLP0P3
RPLP0P3
RPLP0P3
RPLP0P3
RPLP0P3
RPLP0P3
RPLP0P3
RPLP0P3
RPLP0P3
RPLP0P3
RPLP0P3
RPLP0P3
RPLP0P3
RPLP0P3
RPLP0P3
RPLP0P3
RPLP1
RPLP1
RPLP1
RPLP1
RPLP1
RPLP2
RPLP2
RPLP2
RPLP2
RPN1
RPN1
RPP14
RPRD1A

coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR5
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR5
UTR5
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR5
UTR5
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
UTR5
UTR5
UTR3
UTR3
coding_exon
coding_exon

ENST00000352983:HtoD;ENST00000396465:HtoD;ENST00000396466:HtoD;ENST00
ENST00000352983:GtoE;ENST00000396465:GtoE;ENST00000396466:GtoE;ENST000
ENST00000352983:AtoT;ENST00000396465:AtoT;ENST00000396466:AtoT;ENST000
ENST00000352983:AtoS;ENST00000396465:AtoS;ENST00000396466:AtoS;ENST000

ENST00000323345:YtoD;
ENST00000323345:QtoP;
ENST00000323345:LtoQ;
ENST00000323345:HtoD;
ENST00000315731:VtoA;ENST00000323345:VtoA;ENST00000412126:VtoA;
ENST00000315731:VtoA;ENST00000323345:VtoA;ENST00000412126:VtoA;
ENST00000315731:TtoA;ENST00000323345:TtoA;ENST00000412126:TtoA;
ENST00000315731:LtoR;ENST00000323345:YtoD;ENST00000412126:LtoR;
ENST00000315731:LtoR;ENST00000323345:LtoR;ENST00000412126:LtoR;
ENST00000315731:LtoI;ENST00000412126:LtoI;
ENST00000315731:KtoN;ENST00000323345:KtoN;ENST00000412126:KtoN;
ENST00000315731:AtoS;ENST00000323345:AtoS;ENST00000412126:AtoS;

ENST00000304734:RtoG;ENST00000493763:RtoG;

ENST00000228306:StoY;ENST00000313104:StoY;ENST00000392514:StoY;
ENST00000228306:PtoT;ENST00000313104:PtoT;ENST00000392514:PtoT;
ENST00000228306:ItoV;ENST00000392514:ItoV;
ENST00000228306:EtoV;ENST00000313104:EtoV;ENST00000392514:EtoV;
ENST00000228306:EtoQ;ENST00000313104:EtoQ;ENST00000392514:EtoQ;

ENST00000260379:FtoV;ENST00000357790:FtoV;

ENST00000295959:LtoR;ENST00000445193:LtoR;ENST00000466547:LtoR;
ENST00000337059:KtoM;ENST00000357384:KtoM;ENST00000399022:KtoM;

119

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+

CtoG
GtoA
GtoA
GtoT
AtoG
TtoA
AtoG
GtoA
AtoG
AtoG
AtoG
CtoA
AtoT
AtoC
AtoT
AtoT
AtoG
TtoG
CtoT
CtoG
TtoG
AtoC
TtoA
CtoG
TtoC
TtoC
AtoG
TtoG
TtoG
CtoA
AtoC
GtoT
GtoA
CtoA
AtoC
CtoG
AtoC
GtoA
AtoG
GtoA
AtoG
AtoT
GtoC
AtoT
TtoC
TtoC
GtoT
CtoA
AtoT
GtoC
TtoA
AtoG
TtoC
CtoT
CtoT
CtoG
CtoT
CtoT
CtoG
CtoA
CtoA
CtoA
AtoT
TtoA
CtoT
CtoA
CtoA
AtoG
AtoT
GtoC
TtoA
AtoG
TtoA
GtoT
CtoT
AtoG
AtoG
AtoG
AtoG
CtoA
TtoA
AtoG
CtoA
TtoG
AtoG
AtoG
CtoA
CtoT
TtoA
CtoA
CtoT
CtoT
GtoT
TtoG
TtoG
AtoT

0.1176
0.1071
0.1
0.1
0.1111
0.1053
0.2667
0.125
0.1176
0.1
0.1091
0.1429
0.1724
0.1034
0.1176
0.2222
0.1
0.1
0.1
0.1818
0.1026
0.1154
0.1184
0.1034
0.1358
0.1034
0.1107
0.1111
0.1048
0.1096
0.1111
0.1132
0.102
0.1071
0.1176
0.1
0.1111
0.1
0.5
0.1111
0.1
0.2727
0.1
0.1
0.1
0.1
0.1
0.1667
0.1818
0.1111
0.1176
0.1333
0.1
0.1364
0.1103
0.1667
0.1579
0.1111
0.1
0.1
0.8594
0.3511
0.14
0.102
0.1
0.1
0.125
0.1101
0.1
0.1091
0.1
0.1429
0.125
0.125
0.1111
0.1
0.1579
0.1304
0.1
0.1333
0.1034
0.1053
0.1279
0.102
0.1028
0.1628
0.1176
0.125
0.2273
0.1364
0.1
0.1045
0.1053
0.1176
0.1
0.1

0.25
0.4167
0.2308
0.3077
0.4444
0.2273
0.3636
0.25
0.4667
0.4545
0.1111
0.2941
0.1818
0.125
0.1667
0.4
0.186
0.25
0.2727
0.2222
0.1579
0.1282
0.1416
0.1111
0.1784
0.2353
0.1181
0.1143
0.1361
0.1111
0.1296
0.1689
0.2174
0.1364
0.1364
0.125
0.25
0.1429
0.9286
0.1304
0.6667
0.4118
0.1053
0.1667
0.2
0.3333
0.2632
0.1667
0.3
0.1444
0.15
0.1739
0.1053
0.3333
0.1133
0.2609
0.1765
0.25
0.25
0.125
1
0.9158
0.3333
0.2308
0.2308
0.125
0.1463
0.1612
0.2812
0.2812
0.1875
0.1579
0.1569
0.1333
0.2308
0.2727
0.25
0.3077
0.1923
0.3
0.1429
0.1875
0.2727
0.1039
0.18
0.1739
0.3333
0.1429
0.6
0.5455
0.1562
0.1915
0.2308
0.1667
0.1176
0.1111

6
5
10
2
6
6
3
13
7
9
5
7
4
6
6
3
14
10
2
2
9
8
5
7
10
17
15
10
9
12
5
7
9
8
5
7
6
5
13
10
5
3
3
7
11
13
11
2
2
6
4
4
7
12
9
2
4
6
10
5
15
16
11
6
3
4
9
17
13
13
5
7
5
4
7
3
3
8
9
10
9
11
10
13
13
8
4
7
6
8
4
11
6
10
5
3

4
5
5
2
6
5
2
2
4
9
2
3
2
2
3
3
9
5
2
2
4
2
2
3
3
5
3
2
2
2
3
4
7
2
2
3
4
2
13
4
4
3
2
2
5
6
5
2
2
2
2
2
2
9
2
2
2
4
7
2
15
16
5
5
3
2
3
9
11
10
4
2
2
2
4
2
3
5
3
3
4
5
5
3
9
2
3
2
6
8
2
6
5
3
2
2

[17,54]
[11,32]
[10,20]
[10,13]
[10,27]
[17,57]
[11,16]
[12,16]
[12,18]
[10,51]
[27,58]
[17,40]
[22,30]
[24,29]
[12,35]
[14,20]
[14,44]
[13,36]
[11,20]
[10,11]
[21,52]
[26,41]
[79,116]
[47,58]
[180,572]
[72,138]
[257,305]
[65,74]
[131,163]
[75,136]
[54,152]
[53,149]
[23,49]
[22,57]
[17,22]
[16,25]
[10,18]
[22,71]
[10,39]
[24,38]
[10,19]
[11,17]
[10,20]
[13,20]
[10,38]
[16,48]
[10,25]
[12,12]
[10,11]
[57,90]
[17,20]
[15,23]
[10,19]
[10,41]
[417,667]
[23,24]
[17,19]
[15,27]
[10,29]
[10,16]
[19,101]
[66,286]
[15,50]
[13,49]
[10,18]
[16,20]
[32,42]
[245,435]
[28,55]
[30,60]
[10,16]
[14,20]
[42,52]
[16,60]
[13,40]
[11,20]
[12,19]
[10,24]
[13,26]
[10,27]
[28,39]
[39,248]
[48,301]
[763,1126]
[31,113]
[23,43]
[12,17]
[14,16]
[10,37]
[11,32]
[10,32]
[48,152]
[13,51]
[12,18]
[10,18]
[10,19]

TableS10

chr18:31860863
chr20:36152230
chr1:148710871
chr1:148711099
chr6:34500537
chr6:34500556
chr6:34500549
chr6:34500550
chr6:34493216
chr6:34493219
chr6:34493220
chr19:54691503
chr6:133180392
chr6:133180394
chr6:133180396
chr6:133177410
chr11:17052531
chr11:17052532
chr11:17052533
chr11:17052535
chr11:17052536
chr11:17055773
chr11:17055777
chr11:17055778
chr11:17055789
chr11:17055791
chr5:149803989
chr5:149804000
chr5:149809492
chr16:18701786
chr16:18701789
chr16:18701790
chr19:1391483
chr19:1391490
chr19:1391491
chr19:1389417
chr19:44616013
chr19:44616012
chr19:44616019
chr19:44616022
chr19:44616003
chr19:44616004
chr19:44615869
chr19:44615872
chr19:44615873
chr19:44615893
chr19:44615892
chr19:44615702
chr19:44615703
chr19:44618417
chr19:44618418
chr6:33352262
chr6:33347840
chr22:38255047
chr19:47067309
chr19:47067317
chr16:1952779
chr16:1952848
chr16:1954358
chr16:1952657
chr16:1954357
chr16:1952264
chr16:1952592
chr16:1953188
chr16:1952580
chr16:1952579
chr16:1952586
chr16:1952504
chr16:1952872
chr16:1952624
chr16:1952863
chr16:1952768
chr16:1953184
chr16:1952767
chr16:1954304
chr16:1952879
chr16:1952600
chr16:1952501
chr16:1952502
chr16:1952844
chr16:1952500
chr16:1952503
chr16:1952581
chr16:1954353
chr16:1954356
chr16:1954544
chr16:1954559
chr16:1952079
chr16:1954820
chr16:1954828
chr16:1954829
chr16:1954830
chr8:57149202
chr8:57148173
chr8:57149606
chr8:57149607

RPRD1A
RPRD1B
RPRD2
RPRD2
RPS10
RPS10
RPS10
RPS10
RPS10
RPS10
RPS10
RPS11P5
RPS12
RPS12
RPS12
RPS12
RPS13P2
RPS13P2
RPS13P2
RPS13P2
RPS13P2
RPS13P2
RPS13P2
RPS13P2
RPS13P2
RPS13P2
RPS14
RPS14
RPS14
RPS15A
RPS15A
RPS15A
RPS15P5
RPS15P5
RPS15P5
RPS15P5
RPS16P1
RPS16P1
RPS16P1
RPS16P1
RPS16P1
RPS16P1
RPS16P1
RPS16P1
RPS16P1
RPS16P1
RPS16P1
RPS16P1
RPS16P1
RPS16P1
RPS16P1
RPS18
RPS18
RPS19BP1
RPS19P3
RPS19P3
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS2
RPS20
RPS20
RPS20
RPS20

coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR5
UTR5
UTR5
UTR5
UTR3
UTR3
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR5
UTR5
UTR3
UTR5
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR5
UTR5
UTR5
UTR5
coding_exon
mixed
UTR5
UTR5

ENST00000319040:EtoQ;ENST00000337059:EtoQ;ENST00000357384:EtoQ;ENST00
ENST00000369068:DtoE;ENST00000401000:DtoE;
ENST00000326199:YtoC;ENST00000344700:YtoC;ENST00000374053:YtoC;
ENST00000326199:WtoR;ENST00000344700:WtoR;ENST00000374053:WtoR;
ENST00000326199:HtoR;ENST00000344700:HtoR;ENST00000374053:HtoR;
ENST00000326199:HtoD;ENST00000344700:HtoD;ENST00000374053:HtoD;

ENST00000251453:YtoC;ENST00000339471:ItoV;
ENST00000251453:Yto*;ENST00000339471:ItoS;
ENST00000251453:VtoA;ENST00000339471:WtoR;
ENST00000251453:LtoQ;ENST00000339471:WtoR;
ENST00000251453:KtoN;ENST00000339471:NtoI;
ENST00000251453:KtoI;ENST00000339471:NtoY;
ENST00000251453:Kto*;
ENST00000251453:ItoL;ENST00000339471:RtoS;
ENST00000251453:EtoD;ENST00000339471:RtoI;
ENST00000251453:DtoN;ENST00000339471:Wto*;
ENST00000251453:DtoG;ENST00000339471:MtoV;

ENST00000343262:WtoR;
ENST00000343262:VtoL;
ENST00000343262:VtoI;
ENST00000343262:VtoG;
ENST00000343262:VtoD;
ENST00000343262:TtoP;
ENST00000343262:StoP;
ENST00000343262:QtoL;
ENST00000343262:PtoS;
ENST00000343262:PtoL;
ENST00000343262:PtoA;
ENST00000343262:NtoT;
ENST00000343262:LtoV;
ENST00000343262:LtoH;
ENST00000343262:KtoQ;
ENST00000343262:KtoN;
ENST00000343262:KtoN;
ENST00000343262:ItoL;
ENST00000343262:ItoF;
ENST00000343262:HtoQ;
ENST00000343262:GtoD;
ENST00000343262:FtoS;
ENST00000343262:FtoL;
ENST00000343262:AtoV;

ENST00000009589:TtoK;ENST00000427539:TtoK;

120

+
+
+

+
+
+
+
+

+
+
+
+

+
+

+
+

GtoC
TtoC
CtoG
AtoG
AtoG
TtoC
AtoG
CtoG
AtoG
AtoG
AtoG
CtoT
TtoC
AtoG
AtoG
TtoC
AtoG
AtoG
TtoA
AtoG
CtoA
GtoT
GtoT
TtoC
CtoT
TtoC
TtoA
AtoG
TtoC
GtoA
CtoA
TtoA
AtoG
TtoC
CtoG
CtoT
AtoG
TtoG
TtoC
TtoA
AtoT
AtoT
AtoT
AtoC
GtoT
GtoA
AtoG
TtoA
TtoA
GtoT
TtoC
AtoG
CtoG
AtoG
AtoG
AtoG
TtoC
GtoT
GtoA
TtoG
TtoA
AtoC
TtoC
AtoT
CtoT
CtoT
CtoG
AtoC
CtoG
TtoA
AtoC
GtoT
GtoT
AtoC
AtoT
CtoG
GtoA
TtoC
TtoC
CtoT
CtoT
CtoT
GtoT
CtoA
CtoG
TtoG
TtoC
AtoG
CtoT
CtoT
TtoG
TtoG
CtoA
TtoA
AtoT
GtoC

0.1
0.1
0.1
0.1
0.1359
0.103
0.1157
0.1333
0.2308
0.1023
0.1383
0.1148
0.1053
0.1143
0.2222
0.1
0.1304
0.1538
0.1143
0.1373
0.1067
0.1239
0.1083
0.15
0.1071
0.2353
0.1
0.1143
0.1
0.1515
0.1154
0.1455
0.104
0.1619
0.1111
0.1102
0.1538
0.1
0.1
0.1044
0.1111
0.1053
0.1053
0.1818
0.1875
0.1
0.1
0.15
0.24
0.1
0.1071
0.7179
0.125
0.1667
0.1009
0.1205
0.1129
0.1176
0.1107
0.1012
0.5217
0.1102
0.1795
0.1149
0.16
0.1818
0.25
0.1
0.1111
0.1211
0.1333
0.1046
0.1409
0.101
0.1875
0.1056
0.1731
0.3043
0.1
0.1667
0.16
0.1
0.1111
0.1111
0.1111
0.1333
0.1026
0.1
0.1
0.125
0.25
0.2
0.1768
0.2667
0.1111
0.1176

0.1667
0.1538
0.1
0.1429
0.3333
0.1576
0.1407
0.1589
0.3
0.2245
0.3179
0.1795
0.2174
0.5294
0.4167
0.1
0.1429
0.1538
0.3333
0.6029
0.1605
0.2316
0.119
0.3556
0.5152
0.3529
0.1
0.1429
0.1
0.2941
0.1667
0.5
0.1224
0.6364
0.1154
0.1176
0.1538
0.2632
0.1379
0.1421
0.2632
0.3043
0.1556
0.5455
0.8333
0.1538
0.1818
0.3226
0.4828
0.1429
0.45
0.9286
0.1765
0.3077
0.1389
0.4095
0.1452
0.1333
0.2727
0.129
0.7429
0.1389
0.2667
0.1714
0.4167
0.3636
0.3077
0.2143
0.2174
0.129
0.4
0.1732
0.19
0.1875
0.2
0.1508
0.2222
0.6377
0.1765
0.3675
0.4839
0.2778
0.1538
0.3636
0.8158
0.1667
0.3333
0.1667
0.12
0.1333
0.75
0.3
0.1964
0.8182
0.2857
0.3333

3
2
2
2
6
17
9
9
5
16
19
9
11
13
6
5
3
13
18
19
13
4
4
5
4
2
6
8
5
8
11
13
12
15
5
6
6
10
12
17
9
14
9
8
5
4
4
9
10
3
2
5
6
3
4
22
12
2
12
6
2
9
5
8
4
5
2
2
12
10
8
8
12
9
7
12
2
11
10
7
10
7
2
6
11
2
2
5
5
8
4
3
4
6
8
11

2
2
2
2
5
4
2
3
2
8
19
7
3
13
6
2
2
2
12
19
3
2
2
4
3
2
2
2
2
4
6
13
2
15
2
2
2
7
5
7
8
11
5
8
5
2
2
9
10
3
2
5
2
3
3
20
4
2
6
2
2
2
3
2
3
5
2
2
8
2
8
5
3
6
2
5
2
10
4
6
10
6
2
4
11
2
2
2
2
3
4
2
3
6
4
5

[12,20]
[14,20]
[10,10]
[10,14]
[29,110]
[59,244]
[124,138]
[105,199]
[10,13]
[50,118]
[104,360]
[39,79]
[19,42]
[14,67]
[10,34]
[10,10]
[15,23]
[13,14]
[17,59]
[32,158]
[35,81]
[235,465]
[43,121]
[21,102]
[17,34]
[17,18]
[10,10]
[36,49]
[20,20]
[17,33]
[42,116]
[50,235]
[99,416]
[14,704]
[18,26]
[34,118]
[39,40]
[19,63]
[36,139]
[148,320]
[13,28]
[10,28]
[39,74]
[11,39]
[11,31]
[10,13]
[10,11]
[10,44]
[10,56]
[10,34]
[20,29]
[10,42]
[35,56]
[12,13]
[108,327]
[62,232]
[197,423]
[15,17]
[45,303]
[32,173]
[24,36]
[124,152]
[16,40]
[38,151]
[13,25]
[11,23]
[27,40]
[10,14]
[23,121]
[134,241]
[10,44]
[181,865]
[100,149]
[209,805]
[16,31]
[86,589]
[53,120]
[22,70]
[18,55]
[22,118]
[31,108]
[17,21]
[14,19]
[11,112]
[10,232]
[12,15]
[19,86]
[12,31]
[25,30]
[16,25]
[11,23]
[10,11]
[1319,2141]
[11,16]
[44,58]
[21,51]

TableS10

chr8:57149612
chr8:57149615
chr8:57149619
chr20:60396971
chr5:81606948
chr5:81607022
chr5:81607637
chr5:81607640
chr10:79469965
chr10:79470461
chr10:79470463
chr10:79470467
chr10:79470468
chr11:118393360
chr11:118393405
chr11:118393428
chr11:118393429
chr11:118393375
chr11:118393425
chr11:118393365
chr11:118393885
chr11:118393886
chr11:118393892
chr11:118393897
chr11:118393355
chr11:118393376
chr11:118393887
chr11:118394250
chr11:118394263
chr11:118394265
chr1:152230320
chr1:152230319
chr1:152230681
chr1:152230683
chr1:152230727
chr1:152230731
chr1:152230743
chr1:152230746
chr1:152231239
chr1:152231248
chr2:55316245
chr2:55316248
chr2:55316249
chr2:55316250
chr2:55316251
chr2:55313335
chr19:18547045
chr19:18547050
chr19:18547053
chr19:18543670
chr19:18543705
chr19:8292549
chr19:8292589
chr19:8292590
chr19:8293248
chr19:8293264
chr19:8293265
chr19:8292395
chr14:49120045
chr14:49122821
chr14:49122838
chr14:49122839
chr14:49122844
chr4:152243599
chr4:152243671
chr4:152243669
chr4:152243651
chr4:152243602
chr4:152243597
chr4:152243598
chr4:152243676
chr4:152240306
chr4:152243665
chr4:152243666
chr4:152240304
chr4:152243517
chr4:152245218
chr4:152245240
chr4:152245241
chr4:152245243
chr4:152240239
chr11:74794379
chr11:74788227
chr19:63590462
chr19:63590467
chr9:19366626
chr9:19368918
chr9:19368920
chr9:19366252
chr9:19366257
chr9:19370225
chr17:55342754
chr17:55344934
chr2:3605726
chr2:3605727
chr2:3606381

RPS20
RPS20
RPS20
RPS21
RPS23
RPS23
RPS23
RPS23
RPS24
RPS24
RPS24
RPS24
RPS24
RPS25P8
RPS25P8
RPS25P8
RPS25P8
RPS25P8
RPS25P8
RPS25P8
RPS25P8
RPS25P8
RPS25P8
RPS25P8
RPS25P8
RPS25P8
RPS25P8
RPS25P8
RPS25P8
RPS25P8
RPS27
RPS27
RPS27
RPS27
RPS27
RPS27
RPS27
RPS27
RPS27
RPS27
RPS27A
RPS27A
RPS27A
RPS27A
RPS27A
RPS27A
RPS27AP11
RPS27AP11
RPS27AP11
RPS27AP11
RPS27AP11
RPS28
RPS28
RPS28
RPS28
RPS28
RPS28
RPS28
RPS29
RPS29
RPS29
RPS29
RPS29
RPS3AP47
RPS3AP47
RPS3AP47
RPS3AP47
RPS3AP47
RPS3AP47
RPS3AP47
RPS3AP47
RPS3AP47
RPS3AP47
RPS3AP47
RPS3AP47
RPS3AP47
RPS3AP47
RPS3AP47
RPS3AP47
RPS3AP47
RPS3AP47
RPS3P3
RPS3P3
RPS5
RPS5
RPS6
RPS6
RPS6
RPS6
RPS6
RPS6
RPS6KB1
RPS6KB1
RPS7
RPS7
RPS7

UTR5
UTR5
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
mixed
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
UTR5
UTR5
coding_exon
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
UTR3
UTR5
UTR5
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR5
mixed
UTR5
UTR5
UTR5
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR5
mixed
UTR5
UTR5
UTR5
coding_exon
mixed
mixed
UTR3
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
UTR3

ENST00000236900:TtoP;
ENST00000236900:TtoP;
ENST00000236900:NtoI;
ENST00000236900:NtoH;
ENST00000236900:NtoD;
ENST00000236900:LtoS;
ENST00000236900:LtoH;
ENST00000236900:KtoR;
ENST00000236900:KtoE;
ENST00000236900:KtoE;
ENST00000236900:GtoE;

ENST00000368567:PtoA;ENST00000392558:PtoA;
ENST00000368567:CtoW;ENST00000392558:CtoW;

ENST00000417088:VtoI;

ENST00000274065:VtoI;
ENST00000274065:VtoI;
ENST00000274065:VtoE;
ENST00000274065:TtoK;
ENST00000274065:RtoC;
ENST00000274065:QtoP;
ENST00000274065:QtoH;
ENST00000274065:NtoK;
ENST00000274065:KtoE;
ENST00000274065:EtoK;
ENST00000274065:EtoG;
ENST00000274065:AtoD;

ENST00000315377:PtoS;ENST00000380384:PtoS;ENST00000380394:PtoS;

ENST00000225577:LtoP;ENST00000393021:LtoP;ENST00000406116:LtoP;ENST0000
ENST00000225577:GtoE;ENST00000393021:GtoE;ENST00000406116:GtoE;ENST000
ENST00000407445:VtoI;
ENST00000407445:VtoG;

121

+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+

AtoG
TtoG
CtoT
AtoG
AtoG
CtoT
AtoG
AtoG
CtoA
AtoG
GtoA
CtoA
TtoA
AtoC
AtoC
AtoT
AtoC
AtoG
TtoC
TtoA
AtoG
AtoG
AtoG
GtoA
AtoG
CtoA
CtoG
AtoC
CtoT
TtoG
CtoG
CtoG
CtoT
AtoT
CtoG
AtoC
CtoA
CtoA
AtoG
AtoC
TtoA
CtoA
AtoG
TtoA
TtoA
AtoC
GtoA
AtoG
TtoA
CtoT
GtoT
GtoA
TtoA
AtoG
TtoC
TtoA
TtoG
AtoC
CtoA
GtoC
CtoT
AtoT
CtoT
GtoA
GtoA
TtoA
CtoA
CtoT
AtoC
GtoT
TtoA
AtoG
GtoA
AtoG
CtoA
CtoT
AtoG
TtoA
GtoA
TtoA
CtoA
AtoG
GtoT
AtoG
GtoC
CtoT
AtoT
GtoT
TtoA
TtoC
GtoC
TtoC
GtoA
GtoA
TtoG
AtoG

0.1
0.1111
0.5455
0.3636
0.1111
0.1
0.1
0.1241
0.6538
0.1111
0.1
0.1111
0.1
0.1
0.1
0.1071
0.1
0.1034
0.1
0.1
0.1111
0.2
0.1111
0.1021
0.2222
0.1111
0.1026
0.1065
0.2222
0.1
0.1111
0.1667
0.1111
0.1273
0.1172
0.1092
0.1081
0.1364
0.1016
0.1053
0.1
0.1014
0.1053
0.1667
0.1
0.1
0.1016
0.1467
0.1176
0.1538
0.1
0.1
0.3889
0.1
0.1019
0.1333
0.1143
0.1667
0.1
0.1003
0.1053
0.1111
0.125
0.1
0.1034
0.1
0.1042
0.1333
0.1538
0.125
0.1765
0.16
0.1304
0.1111
0.1
0.1
0.1188
0.1714
0.1429
0.6923
0.1087
0.1
0.1163
0.1364
0.1
0.1078
0.1111
0.2
0.8462
0.1034
0.1579
0.1
0.1538
0.1
0.3636
0.125

0.12
0.1538
0.8
0.6
0.1429
0.1818
0.25
0.1932
0.9792
0.2143
0.2727
0.2222
0.1111
0.3
0.1818
0.3
0.3636
0.28
0.3077
0.25
0.2632
0.5938
0.1163
0.1087
0.4444
0.1875
0.125
0.1304
0.6552
0.3
0.1333
0.1818
0.2262
0.1685
0.1719
0.6415
0.125
0.1875
0.125
0.4
0.3793
0.2273
0.3333
0.3333
0.1667
0.1071
0.1268
0.3011
0.1667
0.4615
0.1416
0.1154
0.4
0.4
0.1286
0.1875
0.2667
0.2
0.3333
0.1338
0.1111
0.2
0.2308
0.6389
0.3333
0.3077
0.1628
0.549
0.1667
0.1875
0.2727
0.3333
0.1333
0.1429
0.2
0.1538
0.1717
0.625
0.5
1
0.3333
0.32
0.1957
0.1667
0.2973
0.1555
0.5385
0.5455
0.8889
0.1667
0.2143
0.1
0.1818
0.3846
0.3846
0.1579

7
3
3
3
5
2
4
15
16
12
10
4
2
4
10
6
8
13
16
10
14
15
11
13
3
4
11
10
15
5
7
4
17
16
3
8
7
5
19
10
11
13
11
4
3
6
15
17
6
5
2
4
2
3
16
9
4
3
3
8
7
3
5
6
15
15
10
6
4
5
4
2
10
8
2
2
21
12
11
3
3
13
6
5
5
9
4
4
3
9
3
4
3
3
2
13

2
2
3
3
2
2
2
15
16
7
6
4
2
2
4
4
5
7
10
4
10
15
2
2
3
2
4
3
15
3
2
2
6
2
2
6
2
3
8
3
11
5
6
4
2
2
3
17
2
3
2
3
2
3
8
2
2
2
3
2
2
2
3
6
14
12
2
6
2
5
2
2
3
7
2
2
19
12
10
3
2
11
3
2
4
3
4
4
3
5
2
2
2
3
2
2

[10,26]
[13,19]
[10,12]
[10,12]
[14,18]
[10,11]
[10,12]
[91,613]
[17,90]
[11,34]
[10,22]
[10,18]
[10,22]
[10,10]
[10,35]
[10,29]
[11,31]
[15,33]
[10,48]
[10,16]
[15,64]
[29,107]
[86,91]
[190,238]
[10,22]
[16,27]
[41,81]
[186,295]
[12,53]
[10,12]
[15,18]
[11,12]
[46,191]
[59,92]
[64,285]
[20,120]
[34,39]
[16,22]
[179,511]
[10,19]
[29,139]
[22,70]
[15,42]
[12,18]
[11,18]
[28,30]
[188,491]
[110,246]
[18,31]
[13,47]
[30,113]
[19,26]
[10,19]
[10,22]
[143,513]
[16,16]
[16,37]
[20,36]
[10,17]
[341,804]
[10,19]
[11,19]
[11,16]
[15,55]
[14,93]
[14,86]
[47,51]
[31,80]
[12,14]
[20,32]
[11,17]
[10,26]
[30,92]
[24,77]
[10,15]
[10,13]
[280,1215]
[10,35]
[10,19]
[13,15]
[15,46]
[16,73]
[46,81]
[13,24]
[19,50]
[340,978]
[10,14]
[10,13]
[10,14]
[16,48]
[14,19]
[10,10]
[11,13]
[10,13]
[11,13]
[20,25]

TableS10

chr2:3606382
chr2:3606383
chr2:3600909
chr2:3600912
chr1:45014133
chr1:45014192
chr1:45014193
chr1:45015263
chr1:45016998
chr1:45016999
chr1:45017000
chr1:45013829
chr1:45013832
chr19:59402406
chr19:59403320
chr19:59403321
chr19:59396540
chr3:39428505
chr3:39425192
chr3:39425202
chr3:39427301
chr3:39425205
chr3:39425116
chr3:39427358
chr3:39425118
chr3:39425196
chr3:39428418
chr3:39424185
chr3:39427348
chr3:39424186
chr3:39427350
chr3:39425117
chr3:39427299
chr3:39427359
chr3:39428426
chr3:39423250
chr3:39423253
chr17:76546121
chr3:9858733
chr11:125577537
chr11:125577538
chr2:219168276
chr1:39095307
chr1:39076856
chr6:90134588
chr6:90134607
chr6:90131749
chr6:90133093
chr6:90134401
chr20:17571632
chr20:17565286
chr20:17588409
chr20:17588436
chr20:17588712
chr20:17542591
chr6:7194611
chr11:4087481
chr11:4116310
chr11:4116404
chr8:103320232
chr10:99106846
chr21:43931210
chr21:43921153
chr11:6578547
chr11:6579148
chr11:6578771
chr17:45917274
chr1:114121418
chr7:77245901
chr11:77055653
chr11:77090647
chr11:77090422
chr11:77153306
chr15:53261579
chr16:55830329
chr16:55830959
chr16:55831451
chr3:159555357
chr12:121561613
chr20:61791568
chr20:61797980
chr15:39555229
chr15:39561772
chr15:39562005
chr15:39562303
chr2:55052858
chr2:55053068
chr18:65849150
chr5:178922212
chr4:71869427
chr17:38398758
chr1:25101550
chr1:25098688
chr21:29300679
chr21:29300060
chr6:33271217

RPS7
RPS7
RPS7
RPS7
RPS8
RPS8
RPS8
RPS8
RPS8
RPS8
RPS8
RPS8
RPS8
RPS9
RPS9
RPS9
RPS9
RPSA
RPSA
RPSA
RPSA
RPSA
RPSA
RPSA
RPSA
RPSA
RPSA
RPSA
RPSA
RPSA
RPSA
RPSA
RPSA
RPSA
RPSA
RPSA
RPSA
RPTOR
RPUSD3
RPUSD4
RPUSD4
RQCD1
RRAGC
RRAGC
RRAGD
RRAGD
RRAGD
RRAGD
RRAGD
RRBP1
RRBP1
RRBP1
RRBP1
RRBP1
RRBP1
RREB1
RRM1
RRM1
RRM1
RRM2B
RRP12
RRP1B
RRP1B
RRP8
RRP8
RRP8
RSAD1
RSBN1
RSBN1L
RSF1
RSF1
RSF1
RSF1
RSL24D1
RSPRY1
RSPRY1
RSPRY1
RSRC1
RSRC2
RTEL1
RTEL1
RTF1
RTF1
RTF1
RTF1
RTN4
RTN4
RTTN
RUFY1
RUFY3
RUNDC1
RUNX3
RUNX3
RWDD2B
RWDD2B
RXRB

UTR3
UTR3
UTR5
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR5
UTR5
mixed
UTR3
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
UTR5
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
mixed
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
coding_exon
coding_exon
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon

ENST00000301821:WtoR;ENST00000415859:WtoR;ENST00000443003:WtoR;
ENST00000301821:StoR;ENST00000415859:StoR;ENST00000443003:StoR;
ENST00000301821:StoP;ENST00000415859:StoP;ENST00000443003:StoP;
ENST00000301821:RtoL;ENST00000415859:RtoL;ENST00000443003:RtoL;
ENST00000301821:RtoG;ENST00000415859:RtoG;ENST00000443003:RtoG;
ENST00000301821:NtoT;ENST00000415859:NtoT;ENST00000443003:NtoT;
ENST00000301821:LtoH;ENST00000415859:LtoH;ENST00000443003:LtoH;
ENST00000301821:LtoF;ENST00000415859:LtoF;ENST00000443003:LtoF;
ENST00000301821:ItoL;ENST00000415859:ItoL;ENST00000443003:ItoL;
ENST00000301821:EtoQ;ENST00000415859:EtoQ;ENST00000443003:EtoQ;
ENST00000301821:EtoK;ENST00000415859:EtoK;ENST00000443003:EtoK;
ENST00000301821:EtoK;ENST00000415859:EtoK;ENST00000443003:EtoK;
ENST00000301821:EtoG;ENST00000415859:EtoG;ENST00000443003:EtoG;
ENST00000301821:EtoD;ENST00000415859:EtoD;ENST00000443003:EtoD;

ENST00000306801:VtoG;
ENST00000287624:LtoP;ENST00000383820:LtoP;ENST00000424438:LtoP;ENST0000

ENST00000373001:LtoR;
ENST00000359203:VtoA;ENST00000369415:VtoA;
ENST00000359203:ItoV;ENST00000369415:ItoV;

ENST00000246043:WtoR;ENST00000360807:WtoR;ENST00000377807:WtoR;ENST0
ENST00000246043:VtoG;ENST00000360807:VtoG;ENST00000377807:VtoG;ENST00

ENST00000300738:DtoG;

ENST00000251810:EtoG;ENST00000395910:EtoG;ENST00000395912:EtoG;
ENST00000315563:PtoA;ENST00000370992:PtoA;ENST00000414986:PtoA;
ENST00000340648:KtoN;ENST00000446602:KtoN;
ENST00000254605:VtoG;
ENST00000254605:MtoV;

ENST00000261441:VtoE;ENST00000369581:VtoE;ENST00000434941:VtoE;
ENST00000334955:QtoL;ENST00000445288:QtoL;
ENST00000308488:VtoE;ENST00000360355:VtoE;
ENST00000308488:CtoW;ENST00000360355:CtoW;

ENST00000394420:CtoR;

ENST00000389628:TtoA;ENST00000389629:TtoA;

ENST00000319449:EtoD;ENST00000360569:EtoD;ENST00000377001:EtoD;ENST000
ENST00000226328:RtoS;ENST00000381006:RtoS;ENST00000417478:RtoS;
ENST00000308873:TtoP;ENST00000338888:TtoP;ENST00000399916:TtoP;ENST000
ENST00000493196:LtoH;
ENST00000374685:LtoV;

122

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+

+
+

+
+
+
+

+
+
+
+
+
+

+
+
+

GtoA
TtoA
AtoT
GtoA
GtoC
CtoA
TtoG
AtoG
CtoA
AtoG
TtoA
GtoC
TtoG
TtoG
CtoA
TtoG
CtoT
TtoC
TtoA
TtoC
GtoT
AtoG
AtoC
TtoA
CtoT
AtoC
GtoC
GtoA
GtoA
AtoG
GtoT
TtoC
CtoT
TtoG
AtoG
GtoT
GtoC
TtoG
TtoC
CtoG
CtoA
TtoC
TtoG
AtoG
TtoC
AtoG
GtoT
TtoC
AtoC
TtoC
TtoG
AtoG
GtoC
AtoG
AtoC
CtoA
AtoG
AtoG
GtoA
AtoG
CtoG
AtoT
TtoC
TtoG
AtoG
TtoA
TtoC
TtoA
AtoT
TtoA
TtoG
TtoC
AtoG
TtoC
TtoC
AtoG
GtoT
CtoG
TtoA
TtoC
TtoA
AtoG
AtoG
TtoC
TtoC
AtoG
TtoA
AtoG
GtoT
AtoT
AtoG
AtoC
AtoG
TtoA
GtoA
CtoG

0.1356
0.9
0.2
0.2174
0.1176
0.1379
0.1
0.1176
0.3135
0.1032
0.1316
0.1
0.1176
0.2143
0.1017
0.7857
0.12
0.1538
0.1034
0.1364
0.1176
0.1364
0.1
0.1
0.1111
0.1463
0.2
0.1667
0.1111
0.4167
0.3333
0.1
0.2778
0.1818
0.1
0.1
0.1176
0.1111
0.1
0.2
0.1
0.1111
0.1111
0.125
0.1
0.1
0.1
0.1
0.1176
0.1
0.1143
0.1053
0.129
0.125
0.1
0.1
0.1429
0.1111
0.1
0.1
0.1333
0.1
0.1
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1667
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1538
0.1
0.1538
0.1
0.1
0.1143
0.1
0.1
0.1
0.1
0.12
0.1
0.1
0.1176
0.1

0.5
1
0.25
0.2857
0.1818
0.1579
0.1333
0.1333
0.6118
0.1523
0.3163
0.3
0.1923
0.4286
0.3968
0.9394
0.1714
0.1739
0.5417
0.5455
0.1905
0.1818
0.1111
0.48
0.1875
0.1538
0.3846
0.5
0.1154
0.4545
0.5
0.2
0.3636
0.5789
0.1111
0.2609
0.2097
0.1429
0.1818
0.25
0.1
0.1818
0.1538
0.1304
0.1875
0.1333
0.1818
0.1364
0.1364
0.1
0.1389
0.1538
0.1765
0.1429
0.1667
0.1
0.1667
0.15
0.1667
0.2727
0.1429
0.1
0.1818
0.2
0.1
0.1176
0.1
0.1
0.1818
0.1333
0.1
0.1818
0.1
0.2
0.1143
0.1429
0.125
0.1429
0.1667
0.1
0.1111
0.1875
0.1667
0.1818
0.1111
0.1
0.2558
0.1
0.1
0.1
0.1
0.1325
0.1905
0.1
0.25
0.1818

17
12
2
2
3
3
8
2
19
13
19
7
6
5
10
3
5
2
13
10
5
3
3
3
5
6
3
4
2
2
6
5
2
3
5
13
10
4
3
2
2
7
3
7
3
3
2
3
3
2
7
4
4
2
2
2
4
9
5
5
3
4
2
10
2
5
3
2
5
4
2
6
3
6
10
5
3
2
7
2
3
5
9
2
3
6
10
2
2
3
3
2
4
2
2
3

13
12
2
2
2
2
3
2
19
8
19
5
5
2
10
3
2
2
12
10
3
2
2
3
2
2
3
4
2
2
5
3
2
3
2
6
6
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
3
2
3
2
2
2
2
2
2
3
3
2
2
2
2
2
3
2
2
2
2
2
3
3
2
2
2
4
2
2
2
2
2
3
2
2
2

[10,59]
[10,26]
[15,24]
[14,23]
[11,17]
[19,29]
[15,20]
[15,17]
[124,503]
[93,258]
[37,110]
[10,23]
[17,34]
[14,14]
[26,93]
[15,35]
[26,35]
[14,23]
[15,65]
[11,37]
[14,21]
[11,22]
[10,10]
[10,26]
[16,18]
[14,41]
[10,14]
[10,15]
[27,27]
[11,13]
[16,48]
[10,17]
[11,20]
[12,29]
[10,18]
[18,49]
[11,63]
[14,18]
[11,20]
[10,12]
[10,10]
[12,19]
[10,13]
[16,23]
[10,16]
[10,15]
[10,11]
[10,22]
[17,24]
[20,21]
[36,36]
[19,26]
[17,31]
[14,16]
[10,18]
[10,10]
[12,14]
[18,20]
[10,24]
[10,12]
[15,21]
[10,10]
[10,11]
[10,16]
[10,10]
[17,20]
[10,10]
[10,10]
[10,11]
[10,15]
[10,10]
[10,12]
[10,10]
[16,25]
[20,37]
[10,20]
[10,16]
[10,14]
[12,18]
[10,20]
[10,18]
[13,16]
[10,36]
[11,13]
[10,10]
[10,20]
[22,50]
[10,10]
[10,10]
[10,10]
[10,10]
[50,83]
[21,34]
[10,10]
[12,17]
[10,11]

TableS10

chr6:33272189
chr3:72507252
chr3:72578347
chr3:135377154
chr3:135377161
chr3:135377199
chr3:135377503
chr3:135377562
chr1:151865532
chr1:151773732
chr1:151773736
chr1:33094594
chr1:33095858
chr1:33096420
chr1:33096584
chr1:101479127
chr19:10196386
chr11:18061854
chr19:5551233
chr19:44552461
chr19:44558285
chr19:44566972
chr7:92599575
chr7:92600325
chr7:92614371
chr22:42723719
chr2:128484371
chr2:128484410
chr4:174531208
chr11:68138735
chr10:71587625
chr5:133970241
chr17:23732349
chr17:23712397
chr17:23712406
chr17:23749308
chr12:54437413
chr1:109582267
chr11:65503086
chr12:107440630
chr1:100322132
chr17:7470988
chr17:7470833
chr12:122374283
chr12:122380955
chr4:166478499
chr11:120683711
chr15:72923597
chr19:1868815
chr20:34004962
chr20:34004964
chr15:74808127
chr4:77299169
chr4:83770861
chr4:83770862
chr14:30274668
chr2:238672027
chr1:41265988
chr17:10524865
chr1:53289233
chr17:52429335
chr17:52438738
chr17:52438760
chr8:144946904
chr8:144945463
chr7:29926423
chr17:43270472
chr11:65054753
chr12:99253752
chr4:77110515
chr4:77101207
chr4:77097566
chr4:77105948
chr4:77100260
chr4:77101479
chr4:77101389
chr4:77110510
chr4:77101251
chr4:77101250
chr4:77098044
chr4:77100305
chr4:77100265
chr4:77100355
chr4:77109569
chr4:77113536
chr4:77115950
chr4:77090877
chr8:59651158
chr5:64349990
chr9:138420251
chr9:138422142
chr1:241534687
chr1:241504500
chr17:23999991
chr1:159598931
chr1:159599463

RXRB
RYBP
RYBP
RYK
RYK
RYK
RYK
RYK
S100A13
S100A6
S100A6
S100PBP
S100PBP
S100PBP
S100PBP
S1PR1
S1PR2
SAAL1
SAFB2
SAMD4B
SAMD4B
SAMD4B
SAMD9L
SAMD9L
SAMD9L
SAMM50
SAP130
SAP130
SAP30
SAPS3
SAR1A
SAR1B
SARM1
SARM1
SARM1
SARM1
SARNP
SARS
SART1
SART3
SASS6
SAT2
SAT2
SBNO1
SBNO1
SC4MOL
SC5DL
SCAMP2
SCAMP4
SCAND1
SCAND1
SCAPER
SCARB2
SCD5
SCD5
SCFD1
SCLY
SCMH1
SCO1
SCP2
SCPEP1
SCPEP1
SCPEP1
SCRIB
SCRIB
SCRN1
SCRN2
SCYL1
SCYL2
SDAD1
SDAD1
SDAD1
SDAD1
SDAD1
SDAD1
SDAD1
SDAD1
SDAD1
SDAD1
SDAD1
SDAD1
SDAD1
SDAD1
SDAD1
SDAD1
SDAD1
SDAD1
SDCBP
SDCCAG10
SDCCAG3
SDCCAG3
SDCCAG8
SDCCAG8
SDF2
SDHC
SDHC

coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
coding_exon
coding_exon
mixed
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
mixed
UTR3
mixed
mixed
coding_exon
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
mixed
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
mixed
UTR3

ENST00000374680:StoR;ENST00000374683:StoR;ENST00000374685:StoR;

ENST00000339556:EtoV;ENST00000368699:EtoV;ENST00000392622:EtoV;ENST000

ENST00000317726:StoP;
ENST00000300013:VtoE;
ENST00000314471:WtoR;ENST00000392067:WtoR;ENST00000429637:WtoR;
ENST00000314471:StoC;ENST00000392067:StoC;ENST00000429637:StoC;

ENST00000457710:RtoG;

ENST00000269298:RtoL;ENST00000380466:RtoL;
ENST00000269298:QtoP;ENST00000380466:QtoP;

ENST00000316097:WtoG;ENST00000409472:WtoG;

ENST00000324767:KtoE;

ENST00000262288:VtoE;ENST00000393142:VtoE;

ENST00000320476:VtoG;ENST00000356994:VtoG;ENST00000377533:VtoG;ENST00
ENST00000320476:PtoL;ENST00000356994:PtoL;ENST00000377533:PtoL;ENST0000

ENST00000356260:StoL;ENST00000395710:StoL;ENST00000395711:StoL;
ENST00000356260:RtoW;ENST00000395710:RtoW;ENST00000395711:RtoW;
ENST00000356260:RtoP;ENST00000395710:RtoP;ENST00000395711:RtoP;
ENST00000356260:PtoH;ENST00000395710:PtoH;ENST00000395711:PtoH;
ENST00000356260:NtoS;ENST00000395710:NtoS;ENST00000395711:NtoS;
ENST00000356260:NtoK;ENST00000395710:NtoK;ENST00000395711:NtoK;
ENST00000356260:KtoN;ENST00000395710:KtoN;ENST00000395711:KtoN;
ENST00000356260:ItoV;ENST00000395710:ItoV;ENST00000395711:ItoV;
ENST00000356260:HtoR;ENST00000395710:HtoR;ENST00000395711:HtoR;
ENST00000356260:HtoQ;ENST00000395710:HtoQ;ENST00000395711:HtoQ;
ENST00000356260:DtoN;ENST00000395710:DtoN;ENST00000395711:DtoN;
ENST00000356260:DtoG;ENST00000395710:DtoG;ENST00000395711:DtoG;

ENST00000260130:LtoR;ENST00000413219:LtoR;ENST00000422546:LtoR;ENST000
ENST00000298537:LtoV;ENST00000357365:LtoV;ENST00000371722:LtoV;ENST000
ENST00000298537:LtoP;ENST00000357365:LtoP;ENST00000371722:LtoP;ENST0000
ENST00000343783:QtoR;ENST00000355875:QtoR;ENST00000366541:QtoR;ENST00

123

+
+
+
+
+

+
+
+

+
+

+
+
+
+

+
+

+
+

+
+

+
+
+
+

+
+

+
+

+
+

+
+

CtoG
TtoA
AtoG
GtoA
CtoT
CtoT
GtoC
GtoA
AtoT
TtoA
TtoC
AtoG
AtoG
TtoA
TtoA
AtoC
TtoC
TtoA
AtoG
TtoC
AtoT
TtoA
TtoG
AtoG
TtoG
TtoC
AtoT
GtoC
TtoG
TtoC
TtoC
TtoA
AtoG
TtoG
TtoC
GtoA
AtoG
TtoA
TtoC
TtoC
AtoT
GtoT
AtoC
GtoA
TtoC
TtoA
AtoG
TtoC
TtoG
GtoA
GtoA
AtoG
TtoA
CtoT
CtoA
TtoA
GtoA
TtoC
AtoC
TtoA
TtoA
TtoA
AtoG
TtoG
CtoT
AtoG
GtoA
TtoC
AtoG
CtoT
CtoT
GtoC
CtoA
AtoG
TtoA
GtoT
AtoG
AtoG
CtoG
GtoA
AtoG
AtoG
GtoA
GtoA
GtoA
AtoT
GtoA
TtoG
GtoA
CtoG
TtoC
AtoG
TtoA
TtoG
GtoC
GtoA

0.1818
0.1
0.1
0.1
0.1
0.1
0.1538
0.1
0.1
0.1429
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1429
0.1
0.1333
0.1
0.1333
0.1
0.1
0.1818
0.1143
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1429
0.1
0.1053
0.1
0.1
0.1429
0.1176
0.1
0.1
0.1
0.1111
0.1111
0.1
0.1
0.2
0.1
0.1
0.8182
0.7143
0.1667
0.1429
0.1
0.1
0.1
0.1053
0.1
0.1429
0.1
0.5233
0.1333
0.1
0.1
0.1111
0.1
0.1111
0.1053
0.12
0.1034
0.1
0.1
0.1905
0.1053
0.1111
0.1
0.1
0.1304
0.1111
0.1
0.1
0.1
0.1333
0.1
0.1667
0.1429
0.1053
0.1
0.1
0.1111
0.5116
0.1064

0.2143
0.1
0.1053
0.1667
0.1538
0.2
0.3
0.2308
0.1
0.1786
0.1111
0.1538
0.1667
0.1053
0.1667
0.1053
0.1111
0.2
0.1579
0.1667
0.1
0.2
0.1429
0.1
0.2667
0.129
0.1
0.1
0.1111
0.1
0.1212
0.1
0.1
0.1154
0.125
0.1818
0.1579
0.1111
0.1818
0.2308
0.1
0.1667
0.125
0.1923
0.1
0.1
0.2
0.1818
0.3571
0.3333
0.2667
0.1176
0.1
0.9048
0.9667
0.25
0.2222
0.1
0.2059
0.1538
0.1111
0.1538
0.2
0.1053
0.5816
0.2222
0.1176
0.1
0.1538
0.1667
0.2105
0.2308
0.1429
0.1875
0.1
0.15
0.2
0.1429
0.1176
0.1
0.2727
0.2
0.2
0.2
0.1818
0.1818
0.2
0.1154
0.1667
0.3077
0.1304
0.1
0.1
0.2
0.6364
0.129

2
2
4
4
3
3
4
6
3
4
5
3
5
4
2
4
6
4
3
2
3
9
2
2
2
7
3
2
2
3
8
6
5
5
6
2
7
9
2
9
2
8
3
8
2
4
3
3
2
2
3
3
2
2
3
9
3
2
3
3
8
7
2
2
2
3
2
2
5
6
7
13
6
11
3
6
6
6
7
4
7
12
9
8
4
4
6
4
2
9
7
2
2
12
2
4

2
2
2
2
2
2
2
4
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
3
2
2
2
2
5
2
2
2
3
2
2
2
3
2
2
2
3
2
2
3
2
2
2
2
2
2
3
2
2
2
2
2
2
2
4
3
4
2
4
2
3
2
3
2
2
6
4
4
4
2
2
2
2
2
4
2
2
2
7
2
2

[11,14]
[10,10]
[10,19]
[10,12]
[10,13]
[10,10]
[10,13]
[10,14]
[10,10]
[14,30]
[10,18]
[10,13]
[12,18]
[10,20]
[10,12]
[11,19]
[10,18]
[14,15]
[19,20]
[12,15]
[10,10]
[11,15]
[11,15]
[10,10]
[11,15]
[31,35]
[10,10]
[10,10]
[18,19]
[10,10]
[33,41]
[10,10]
[10,10]
[10,26]
[16,19]
[10,22]
[19,21]
[10,18]
[11,19]
[13,31]
[10,10]
[12,21]
[16,17]
[10,26]
[10,10]
[10,10]
[10,18]
[11,27]
[10,14]
[10,27]
[10,15]
[10,20]
[10,10]
[12,21]
[14,30]
[12,12]
[14,18]
[10,10]
[10,34]
[10,13]
[18,19]
[13,20]
[10,14]
[10,19]
[86,98]
[15,19]
[10,17]
[10,10]
[13,18]
[17,30]
[17,27]
[13,19]
[21,25]
[14,29]
[10,10]
[10,20]
[15,21]
[14,19]
[17,18]
[10,20]
[10,22]
[15,23]
[10,18]
[10,15]
[10,11]
[10,11]
[15,15]
[10,26]
[12,12]
[12,18]
[19,23]
[10,10]
[10,10]
[14,30]
[33,45]
[31,47]

TableS10

chr1:159599464
chr15:83013828
chr17:72721729
chr17:72722428
chr17:72722451
chr17:72723138
chr9:138486320
chr9:138488805
chr9:138455418
chr9:138455444
chr9:138455703
chr9:138455787
chr9:138455876
chr3:42564887
chr14:38572269
chr20:18461350
chr10:121682611
chr5:134061637
chr5:134084670
chr10:75200209
chr4:119864125
chr4:83967590
chr4:83967678
chr4:84003546
chr10:102239485
chr10:102236764
chr3:129254409
chr3:129271279
chr10:12246320
chr10:12249578
chr9:101032694
chr9:101032695
chr7:54787499
chr3:171176184
chr3:171188810
chr3:171193691
chr6:108321458
chr6:108298846
chr6:108299387
chr18:12977017
chr18:12977399
chr14:81042186
chr14:81009716
chr1:154413017
chr2:96893831
chr9:91183884
chr9:91183080
chr9:91183086
chr12:46723944
chr12:46724158
chr3:186812133
chr3:186830879
chr3:186831068
chr3:186831165
chr3:198143489
chr4:78152073
chr4:78160765
chr4:78174717
chr4:78174749
chr4:78176072
chr4:78176438
chr4:78176494
chr4:78178391
chr2:241940596
chr7:35807406
chr5:132120562
chr17:73008263
chr16:1928445
chr15:41874100
chr15:41873538
chr15:41873539
chr11:17966785
chr1:31678493
chr1:31680044
chr20:42560841
chr3:151744247
chr3:151744258
chr3:151744392
chr3:151764816
chr3:151772449
chr3:151784481
chr19:45620630
chr2:64713895
chr2:64714901
chr19:45639352
chr1:28468296
chr9:130493976
chr9:130495808
chr9:130494020
chr9:130494007
chr9:130494014
chr9:130493960
chr9:130494055
chr9:130494830
chr9:130494828
chr9:130494836

SDHC
SEC11B
SEC14L1
SEC14L1
SEC14L1
SEC14L1
SEC16A
SEC16A
SEC16A
SEC16A
SEC16A
SEC16A
SEC16A
SEC22C
SEC23A
SEC23B
SEC23IP
SEC24A
SEC24A
SEC24C
SEC24D
SEC31A
SEC31A
SEC31A
SEC31B
SEC31B
SEC61A1
SEC61A1
SEC61A2
SEC61A2
SEC61B
SEC61B
SEC61G
SEC62
SEC62
SEC62
SEC63
SEC63
SEC63
SEH1L
SEH1L
SEL1L
SEL1L
SEMA4A
SEMA4C
SEMA4D
SEMA4D
SEMA4D
SENP1
SENP1
SENP2
SENP2
SENP2
SENP2
SENP5
SEPT11
SEPT11
SEPT11
SEPT11
SEPT11
SEPT11
SEPT11
SEPT11
SEPT2
SEPT7
SEPT8
SEPT9
SEPX1
SERF2
SERF2
SERF2
SERGEF
SERINC2
SERINC2
SERINC3
SERP1
SERP1
SERP1
SERP1
SERP1
SERP1
SERTAD1
SERTAD2
SERTAD2
SERTAD3
SESN2
SET
SET
SET
SET
SET
SET
SET
SET
SET
SET

UTR3
UTR3
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
coding_exon
coding_exon
mixed
coding_exon
UTR3
mixed
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
mixed
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
mixed
mixed
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
mixed
UTR3
UTR3
coding_exon
mixed
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR5
UTR5
coding_exon
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon

ENST00000262544:VtoI;ENST00000336714:VtoI;ENST00000377465:VtoI;ENST0000
ENST00000369075:KtoE;
ENST00000398844:CtoR;

ENST00000264405:NtoD;ENST00000311785:NtoD;ENST00000348405:NtoD;ENST00

ENST00000370345:AtoS;

ENST00000298428:LtoR;ENST00000379020:LtoR;ENST00000379033:LtoR;

ENST00000337002:VtoD;ENST00000480708:VtoD;
ENST00000337002:CtoW;ENST00000480708:CtoW;
ENST00000369002:Lto*;

ENST00000336735:WtoR;
ENST00000355014:FtoI;ENST00000368282:FtoI;ENST00000368283:FtoI;ENST00000
ENST00000343780:NtoS;ENST00000356444:NtoS;ENST00000422704:NtoS;ENST000

ENST00000264893:VtoA;
ENST00000264893:TtoP;

ENST00000265965:HtoR;
ENST00000373709:VtoE;ENST00000373710:VtoE;

ENST00000357949:LtoM;

ENST00000322354:VtoG;ENST00000392028:VtoG;
ENST00000253063:RtoW;
ENST00000322030:StoR;ENST00000372686:StoR;ENST00000372688:StoR;ENST000
ENST00000322030:StoI;ENST00000372686:StoI;ENST00000372688:StoI;ENST00000
ENST00000322030:QtoR;ENST00000372686:QtoR;ENST00000372688:QtoR;ENST00
ENST00000322030:NtoH;ENST00000372686:NtoH;ENST00000372688:NtoH;ENST00
ENST00000322030:LtoP;ENST00000372686:LtoP;ENST00000372688:LtoP;ENST0000
ENST00000322030:LtoH;ENST00000372686:LtoH;ENST00000372688:LtoH;ENST000
ENST00000322030:KtoE;ENST00000372686:KtoE;ENST00000372688:KtoE;ENST000
ENST00000322030:FtoI;ENST00000372686:FtoI;ENST00000372688:FtoI;ENST00000
ENST00000322030:EtoG;ENST00000372686:EtoG;ENST00000372688:EtoG;ENST000
ENST00000322030:DtoN;ENST00000372686:DtoN;ENST00000372688:DtoN;ENST00

124

+
+
+
+

+
+
+
+
+

+
+
+
+
+
+

+
+
+

+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+

+
+

+
+
+
+
+
+
+
+
+
+
+

AtoG
TtoC
AtoG
AtoG
TtoC
CtoA
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
TtoA
GtoA
AtoG
TtoC
AtoC
TtoC
TtoA
AtoG
AtoC
TtoA
GtoT
TtoC
CtoT
AtoG
TtoG
AtoT
TtoA
AtoG
GtoT
TtoA
TtoG
TtoC
TtoA
TtoC
TtoG
TtoC
TtoG
TtoC
TtoA
TtoA
GtoC
AtoG
TtoG
TtoC
TtoC
TtoC
TtoC
TtoC
TtoC
TtoA
TtoA
TtoC
AtoC
AtoG
TtoC
TtoC
AtoG
GtoT
TtoA
TtoC
GtoC
TtoC
GtoA
TtoG
AtoG
TtoA
TtoA
AtoG
TtoA
CtoG
TtoC
CtoT
TtoA
TtoA
TtoC
TtoC
TtoC
CtoA
CtoA
TtoG
TtoG
CtoT
TtoA
GtoT
AtoG
AtoC
TtoC
TtoA
AtoG
TtoA
AtoG
GtoA

0.125
0.1
0.1
0.1
0.125
0.4571
0.1
0.1
0.1
0.1
0.1
0.1667
0.1333
0.1
0.1429
0.4103
0.1
0.1
0.1
0.1111
0.1176
0.1
0.1129
0.125
0.1
0.1
0.125
0.1111
0.1
0.3
0.1111
0.1053
0.1304
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.125
0.1
0.1
0.1
0.1154
0.1
0.1034
0.1
0.1
0.1
0.125
1
0.1
0.1
0.1111
0.1
0.1111
0.1
0.1667
0.1
0.2308
0.1
0.1364
0.1176
0.1081
0.1111
0.1026
0.1053
0.1
0.1429
0.1111
0.1
0.4545
0.1
0.1818
0.125
0.1
0.3571
0.1053
0.125
0.1034
0.1176
0.1667

0.1364
0.2105
0.1053
0.1333
0.125
0.5221
0.1053
0.1111
0.4167
0.3
0.5333
0.1765
0.1364
0.1
0.1538
0.5
0.1538
0.1579
0.1429
0.1176
0.1333
0.1148
0.1698
0.1667
0.1
0.1429
0.1304
0.1143
0.1
0.6
0.1111
0.3
0.3
0.1351
0.1071
0.2
0.1
0.1538
0.1
0.1429
0.1
0.1818
0.2
0.1304
0.1818
0.1429
0.1053
0.1364
0.1
0.1
0.1
0.1111
0.1
0.1429
0.1
0.1471
0.1429
0.1864
0.1429
0.1429
0.2
0.1
0.1053
0.1429
1
0.1
0.1111
0.1538
0.2727
0.1875
0.2143
0.2
0.1961
0.4364
0.2667
0.1667
0.2727
0.1379
0.25
0.12
0.1111
0.1
0.1818
0.1538
0.1
0.5714
0.2308
0.2
0.25
0.1
0.5
0.25
0.125
0.1143
0.1746
0.4

5
10
2
6
2
2
2
2
16
9
14
3
4
2
5
2
2
5
4
2
6
12
5
3
2
2
2
7
2
3
2
2
3
11
2
7
2
5
4
2
3
4
5
2
3
2
8
5
2
2
2
3
3
6
2
6
7
8
4
7
11
3
4
6
4
4
9
5
2
3
2
5
4
4
2
7
3
5
14
3
5
2
2
6
4
2
7
6
8
3
6
3
9
10
7
3

2
3
2
3
2
2
2
2
12
6
12
2
2
2
2
2
2
2
2
2
2
2
4
2
2
2
2
2
2
3
2
2
2
2
2
4
2
2
2
2
2
3
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
5
2
2
2
4
2
2
3
2
3
2
2
3
4
2
2
3
3
7
2
2
2
2
2
2
2
4
2
4
2
6
3
2
2
3
3

[32,44]
[12,22]
[10,19]
[10,20]
[16,17]
[70,113]
[10,19]
[10,10]
[18,45]
[10,56]
[15,35]
[12,17]
[15,22]
[10,11]
[13,14]
[12,118]
[10,13]
[10,19]
[10,14]
[10,17]
[15,17]
[61,61]
[51,62]
[13,16]
[10,10]
[10,14]
[17,23]
[27,35]
[10,10]
[10,11]
[10,10]
[10,20]
[10,23]
[40,41]
[19,28]
[10,17]
[10,10]
[10,26]
[10,10]
[10,14]
[10,10]
[10,19]
[10,17]
[18,23]
[10,11]
[10,14]
[10,19]
[10,24]
[10,10]
[10,10]
[10,10]
[10,27]
[10,10]
[14,17]
[10,10]
[20,34]
[14,40]
[38,59]
[14,30]
[14,29]
[10,18]
[10,20]
[11,20]
[14,24]
[15,23]
[10,10]
[10,18]
[18,27]
[10,11]
[10,16]
[10,14]
[10,12]
[20,51]
[12,55]
[15,20]
[12,22]
[11,35]
[22,37]
[16,27]
[25,39]
[19,27]
[10,10]
[11,14]
[13,18]
[10,10]
[11,14]
[10,19]
[11,15]
[14,28]
[10,10]
[11,28]
[20,21]
[16,49]
[31,38]
[17,63]
[10,12]

TableS10

chr9:130493958
chr9:130493973
chr9:130494024
chr9:130494826
chr9:130494835
chr9:130495806
chr9:130495809
chr3:47102786
chr3:47104731
chr3:47133155
chr14:98940332
chr14:99001881
chr14:98934703
chr3:9461810
chr3:9452419
chr3:9493173
chr16:57109574
chr1:149167073
chr1:149186107
chr1:149203504
chr9:134191681
chr9:134192354
chr9:134191892
chr9:134127389
chr9:134128238
chr9:134128536
chr11:64288663
chr11:64289398
chr2:197965283
chr2:197965044
chr11:65583054
chr19:19268854
chr22:30311089
chr22:30344465
chr10:7241336
chr10:7242216
chr10:7242269
chr10:7243962
chr1:35414580
chr1:35416221
chr1:35416796
chr1:35417582
chr1:35422397
chr1:35422398
chr17:53436363
chr5:65511360
chr5:65512148
chr19:18997211
chr19:18964881
chr19:18965446
chr21:31995967
chr21:31995179
chr21:32000515
chr6:99955144
chr6:99955140
chr6:99954772
chr17:72242735
chr17:72242736
chr17:72242747
chr17:72243448
chr11:94441462
chr11:94441463
chr12:44606989
chr6:36670130
chr6:36670131
chr1:29346996
chr14:69308438
chr14:69303727
chr14:69303847
chr14:69303848
chr20:41524166
chr20:41524171
chr20:41525617
chr12:130776121
chr12:130807102
chr12:119383892
chr12:119383894
chr6:166658051
chr1:166467730
chr5:174887433
chr10:104485618
chr10:104487689
chr10:104487858
chr10:104487872
chr10:120895771
chr7:94055951
chr6:134533920
chr10:51773471
chr2:201144344
chr10:72308323
chr17:75797934
chr17:75797956
chr22:39134968
chr22:39132451
chr16:28787871
chr16:28788191

SET
SET
SET
SET
SET
SET
SET
SETD2
SETD2
SETD2
SETD3
SETD3
SETD3
SETD5
SETD5
SETD5
SETD6
SETDB1
SETDB1
SETDB1
SETX
SETX
SETX
SETX
SETX
SETX
SF1
SF1
SF3B1
SF3B1
SF3B2
SF4
SFI1
SFI1
SFMBT2
SFMBT2
SFMBT2
SFMBT2
SFPQ
SFPQ
SFPQ
SFPQ
SFPQ
SFPQ
SFRS1
SFRS12
SFRS12
SFRS14
SFRS14
SFRS14
SFRS15
SFRS15
SFRS15
SFRS18
SFRS18
SFRS18
SFRS2
SFRS2
SFRS2
SFRS2
SFRS2B
SFRS2B
SFRS2IP
SFRS3
SFRS3
SFRS4
SFRS5
SFRS5
SFRS5
SFRS5
SFRS6
SFRS6
SFRS6
SFRS8
SFRS8
SFRS9
SFRS9
SFT2D1
SFT2D2
SFXN1
SFXN2
SFXN2
SFXN2
SFXN2
SFXN4
SGCE
SGK1
SGMS1
SGOL2
SGPL1
SGSH
SGSH
SGSM3
SGSM3
SH2B1
SH2B1

coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
mixed
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
mixed
coding_exon
UTR5
UTR5
UTR3
UTR3
UTR5
UTR5
UTR5
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
mixed
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
mixed
coding_exon
coding_exon

ENST00000409792:LtoP;ENST00000451092:LtoP;
ENST00000409792:EtoG;ENST00000451092:EtoG;
ENST00000331768:VtoE;

ENST00000302463:EtoD;ENST00000402198:EtoD;ENST00000402466:EtoD;ENST000
ENST00000302463:DtoE;ENST00000402198:DtoE;ENST00000402466:DtoE;ENST000

ENST00000271640:RtoG;ENST00000368960:RtoG;ENST00000368962:RtoG;ENST00
ENST00000271640:NtoT;ENST00000368969:NtoT;
ENST00000224140:KtoE;ENST00000372169:KtoE;ENST00000393220:KtoE;
ENST00000224140:EtoD;ENST00000372169:EtoD;ENST00000393220:EtoD;

ENST00000335508:YtoN;
ENST00000322535:NtoD;
ENST00000247001:LtoP;
ENST00000400288:LtoQ;ENST00000400289:LtoQ;ENST00000414585:LtoQ;ENST000

ENST00000330854:FtoV;ENST00000337018:FtoV;ENST00000392342:FtoV;ENST000

ENST00000286835:GtoV;ENST00000399804:GtoV;ENST00000419806:GtoV;ENST00

ENST00000369239:Sto*;ENST00000438806:Sto*;

ENST00000369367:QtoR;

ENST00000271375:LtoQ;ENST00000367825:LtoQ;ENST00000367829:LtoQ;
ENST00000369893:FtoL;

ENST00000265735:QtoR;ENST00000379889:QtoR;ENST00000415788:QtoR;ENST00
ENST00000361781:LtoQ;
ENST00000357799:CtoS;

ENST00000248929:NtoS;ENST00000454798:NtoS;
ENST00000337120:QtoR;ENST00000359285:QtoR;ENST00000395532:QtoR;
ENST00000337120:DtoA;ENST00000359285:DtoA;ENST00000395532:DtoA;

125

+
+
+
+
+
+
+

+
+
+
+
+
+
+

+
+

+
+

+
+

+
+

+
+
+
+
+
+
+
+
+

+
+
+
+
+
+

+
+

+
+
+
+

AtoG
CtoG
AtoT
AtoG
AtoG
GtoA
CtoT
TtoC
AtoG
TtoC
TtoA
TtoC
TtoG
AtoC
TtoG
GtoA
CtoT
AtoG
AtoC
CtoT
AtoG
GtoT
AtoC
TtoA
GtoA
TtoC
GtoA
TtoA
TtoA
GtoA
AtoG
TtoC
TtoA
AtoG
AtoG
TtoG
TtoC
AtoC
AtoG
AtoG
GtoT
TtoC
AtoT
TtoC
AtoT
TtoC
CtoA
TtoG
TtoG
GtoT
GtoT
GtoA
TtoC
CtoA
GtoA
AtoG
TtoG
TtoC
TtoA
GtoA
CtoA
CtoA
AtoG
GtoC
AtoT
TtoA
CtoA
TtoA
CtoG
GtoT
TtoC
TtoA
TtoA
GtoA
AtoG
AtoG
CtoA
TtoG
TtoA
TtoC
CtoG
GtoA
AtoG
AtoG
AtoG
AtoG
AtoG
TtoA
TtoA
AtoG
TtoC
GtoA
AtoG
TtoC
AtoG
AtoC

0.1212
0.1
0.1
0.1008
0.1
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.15
0.1
0.1
0.1
0.1
0.1
0.1034
0.1
0.1
0.1
0.1
0.1111
0.1429
0.1
0.125
0.1071
0.1
0.1029
0.1053
0.1
0.1
0.1
0.1
0.1429
0.1
0.1525
0.1
0.1
0.1
0.1111
0.1029
0.1143
0.1
0.1
0.1111
0.1
0.1111
0.1
0.125
0.1333
0.1
0.12
0.1053
0.1071
0.1042
0.1154
0.1053
0.1176
0.1053
0.1
0.1
0.1111
0.1
0.1333
0.1
0.1111
0.1026
0.1
0.1
0.1176
0.1
0.1111
0.1429
0.1282
0.1084
0.1
0.1
0.1
0.1
0.1
0.1538
0.1111
0.1
0.1
0.1
0.1
0.1
0.1026
0.1667
0.1
0.1163
0.125
0.1

0.1333
0.1379
0.1818
0.1135
0.1818
0.1538
0.1429
0.1
0.1538
0.1
0.2
0.1364
0.1176
0.1667
0.1
0.1481
0.1
0.1
0.3529
0.5833
0.1111
0.1
0.2
0.1176
0.125
0.1538
0.1333
0.1429
0.3529
0.1818
0.1538
0.1111
0.125
0.25
0.1
0.1
0.1667
0.1
0.3571
0.25
0.1
0.2
0.1579
0.1507
0.1304
0.3077
0.1333
0.25
0.1
0.1667
0.1
0.1667
0.1579
0.3636
0.4
0.1667
0.1154
0.1154
0.2
0.375
0.125
0.1875
0.2
0.2
0.2
0.1
0.4545
0.1
0.1333
0.129
0.1053
0.1818
0.125
0.1538
0.1111
0.2727
0.1667
0.2097
0.1
0.1081
0.1
0.3333
0.1538
0.1667
0.1176
0.1
0.1429
0.1
0.2
0.1429
0.1739
0.2
0.1667
0.1667
0.1667
0.1

4
7
4
16
3
6
3
3
2
3
4
4
6
2
2
2
2
4
2
3
2
2
3
3
9
4
3
5
9
4
7
4
3
2
2
3
2
2
3
2
2
8
7
4
3
7
2
3
2
6
2
7
2
9
4
8
7
12
16
13
3
4
6
4
3
2
5
3
7
8
4
4
4
5
2
7
8
14
4
3
2
4
2
2
4
3
2
3
2
3
6
3
9
6
6
2

3
2
3
3
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
3
2
4
2
2
2
2
2
2
2
2
2
3
2
2
2
3
3
2
4
2
2
2
2
2
2
2
4
4
4
2
2
6
5
2
2
2
3
3
2
4
2
4
3
2
2
2
2
2
6
2
10
2
2
2
2
2
2
2
2
2
2
2
2
5
2
2
2
3
2

[15,33]
[10,29]
[10,15]
[123,170]
[10,11]
[11,17]
[14,15]
[10,10]
[10,13]
[10,10]
[10,15]
[10,23]
[10,34]
[12,20]
[10,10]
[10,27]
[10,10]
[10,10]
[10,17]
[12,29]
[10,18]
[10,10]
[10,17]
[10,17]
[16,27]
[13,14]
[10,20]
[14,40]
[13,29]
[10,22]
[39,68]
[18,19]
[16,20]
[10,12]
[10,10]
[10,10]
[12,14]
[10,10]
[12,65]
[10,12]
[10,10]
[10,11]
[25,77]
[29,73]
[35,116]
[10,15]
[10,15]
[10,12]
[10,10]
[13,18]
[10,11]
[12,16]
[15,19]
[10,17]
[10,47]
[13,19]
[26,28]
[27,48]
[21,84]
[15,32]
[16,17]
[16,19]
[10,10]
[10,20]
[10,18]
[10,10]
[11,21]
[10,10]
[17,36]
[17,39]
[10,19]
[11,11]
[17,17]
[13,20]
[18,27]
[10,17]
[13,39]
[40,163]
[10,10]
[10,37]
[10,10]
[12,20]
[10,13]
[12,13]
[17,18]
[10,10]
[10,14]
[10,20]
[10,10]
[10,14]
[19,39]
[12,15]
[12,21]
[12,43]
[13,18]
[10,10]

TableS10

chr16:28792291
chr12:110370178
chr12:110371229
chr12:110372045
chr12:110372534
chr9:129580700
chr9:129541783
chr9:129553300
chr4:2796651
chr4:2801116
chr3:15271888
chr3:15272510
chr1:247073175
chr1:247072344
chr17:40837419
chr1:86981578
chr10:105352305
chr4:8288125
chr16:45174955
chr16:45209136
chr12:55914777
chr12:55914778
chr10:112735472
chr10:112713902
chr3:72944533
chr5:132186255
chr11:124011655
chr11:124011656
chr3:114827716
chr3:114827717
chr11:116571805
chr19:56612378
chr11:111100406
chr1:115115165
chr15:73449306
chr15:73451163
chr14:38675563
chr14:71241751
chr19:43271249
chr19:43264917
chr19:43264929
chr20:1853479
chr6:13720083
chr17:77465692
chr9:35640389
chr9:35639326
chr17:43594930
chr7:26676315
chr7:26675112
chr6:32036080
chr5:54655746
chr5:54639611
chr5:133524650
chr5:133524643
chr13:77235440
chr4:48118832
chr4:48118930
chr4:48120669
chr1:158759594
chr1:158725583
chr1:158987193
chr1:158987465
chr16:66537236
chr15:32334843
chr15:32316252
chr15:32310901
chr15:32311054
chr3:126284763
chr3:126284764
chr11:60463685
chr12:127843784
chr1:113261772
chr1:113273340
chr1:113256688
chr1:113256877
chr1:113256882
chr17:77790645
chr17:77790646
chr17:77790647
chr20:61069309
chr2:65103604
chr2:113132905
chr2:113137494
chr5:138733093
chr20:4803311
chr20:4791482
chr20:4899564
chr22:17543395
chr22:17543578
chr22:17543581
chr17:77297298
chr2:172352334
chr7:95599065
chr10:69916954
chr22:39520485
chr22:39496235

SH2B1
SH2B3
SH2B3
SH2B3
SH2B3
SH2D3C
SH2D3C
SH2D3C
SH3BP2
SH3BP2
SH3BP5
SH3BP5
SH3BP5L
SH3BP5L
SH3D20
SH3GLB1
SH3PXD2A
SH3TC1
SHCBP1
SHCBP1
SHMT2
SHMT2
SHOC2
SHOC2
SHQ1
SHROOM1
SIAE
SIAE
SIDT1
SIDT1
SIDT2
SIGLEC10
SIK2
SIKE1
SIN3A
SIN3A
SIP1
SIPA1L1
SIPA1L3
SIPA1L3
SIPA1L3
SIRPA
SIRT5
SIRT7
SIT1
SIT1
SKAP1
SKAP2
SKAP2
SKIV2L
SKIV2L2
SKIV2L2
SKP1
SKP1
SLAIN1
SLAIN2
SLAIN2
SLAIN2
SLAMF6
SLAMF6
SLAMF7
SLAMF7
SLC12A4
SLC12A6
SLC12A6
SLC12A6
SLC12A6
SLC12A8
SLC12A8
SLC15A3
SLC15A4
SLC16A1
SLC16A1
SLC16A1
SLC16A1
SLC16A1
SLC16A3
SLC16A3
SLC16A3
SLC17A9
SLC1A4
SLC20A1
SLC20A1
SLC23A1
SLC23A2
SLC23A2
SLC23A2
SLC25A1
SLC25A1
SLC25A1
SLC25A10
SLC25A12
SLC25A13
SLC25A16
SLC25A17
SLC25A17

mixed
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
mixed
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR5
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
mixed
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR5
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3

ENST00000341259:NtoD;

ENST00000314830:KtoE;

ENST00000356331:StoG;ENST00000442312:StoG;ENST00000452765:StoG;
ENST00000356331:KtoE;ENST00000435136:KtoE;ENST00000442312:KtoE;ENST000

ENST00000376922:RtoK;ENST00000428638:RtoK;ENST00000442348:RtoK;ENST000
ENST00000315994:GtoV;ENST00000355946:GtoV;ENST00000369774:GtoV;
ENST00000303383:QtoR;
ENST00000303383:EtoK;

ENST00000369452:DtoA;
ENST00000325599:TtoA;ENST00000463369:TtoA;

ENST00000264852:HtoQ;ENST00000393830:HtoQ;
ENST00000264852:FtoI;ENST00000393830:FtoI;
ENST00000339313:VtoE;ENST00000353836:VtoE;ENST00000432469:VtoE;ENST000

ENST00000358550:StoG;ENST00000381232:StoG;
ENST00000222345:VtoG;
ENST00000222345:LtoP;
ENST00000222345:DtoG;
ENST00000356025:LtoQ;ENST00000358771:LtoQ;ENST00000400068:LtoQ;ENST000
ENST00000328666:TtoP;
ENST00000259608:VtoG;
ENST00000336915:VtoG;
ENST00000345317:WtoG;
ENST00000375394:LtoP;ENST00000433155:LtoP;
ENST00000230640:VtoG;
ENST00000230640:FtoL;
ENST00000328392:RtoQ;ENST00000353411:RtoQ;

ENST00000264313:WtoL;

ENST00000368055:FtoV;ENST00000368057:FtoV;ENST00000368059:FtoV;

ENST00000290209:EtoG;ENST00000354181:EtoG;ENST00000397702:EtoG;ENST000

ENST00000369626:HtoR;

ENST00000272542:LtoV;ENST00000409095:LtoV;

ENST00000338244:YtoD;ENST00000379324:YtoD;ENST00000379333:YtoD;ENST000
ENST00000338244:StoR;ENST00000379324:StoR;ENST00000379333:StoR;ENST000

ENST00000331531:KtoN;ENST00000350690:KtoN;
ENST00000422440:Gto*;
ENST00000265631:HtoR;ENST00000416240:HtoR;
ENST00000435456:EtoG;

126

+
+
+
+
+

+
+

+
+
+
+

+
+
+

+
+
+
+
+
+
+

+
+
+

+
+
+
+

+
+

+
+
+
+
+
+
+

AtoC
AtoG
TtoC
AtoG
TtoG
AtoG
GtoA
CtoA
AtoG
AtoG
TtoG
AtoG
GtoC
TtoA
GtoA
TtoA
GtoT
TtoG
AtoG
GtoA
CtoA
CtoA
AtoC
AtoG
AtoG
CtoT
TtoG
TtoG
CtoG
TtoA
CtoG
TtoA
AtoT
TtoA
AtoG
AtoC
TtoC
AtoG
TtoG
TtoC
AtoG
TtoA
TtoC
AtoC
TtoG
TtoC
TtoG
TtoG
CtoG
TtoC
TtoG
TtoC
GtoA
TtoC
TtoC
GtoT
AtoG
AtoG
TtoG
AtoC
GtoA
TtoC
CtoA
AtoG
GtoA
AtoG
TtoC
AtoG
AtoG
AtoG
TtoC
AtoG
AtoG
TtoC
GtoA
AtoG
CtoA
CtoA
AtoG
AtoC
AtoT
TtoG
GtoA
AtoC
TtoG
CtoA
TtoC
TtoC
CtoT
TtoA
GtoT
GtoT
AtoG
TtoC
AtoG
CtoA

0.1
0.125
0.1333
0.1
0.1176
0.1
0.1
0.1
0.12
0.1
0.1667
0.1
0.1
0.1
0.1429
0.1176
0.1
0.1
0.1
0.1
0.1739
0.1
0.1
0.1
0.1
0.1
0.1111
0.1333
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1667
0.1667
0.1
0.1
0.1
0.1111
0.1053
0.1
0.1
0.1
0.1
0.1
0.1429
0.1176
0.1034
0.1071
0.1
0.1333
0.1
0.1429
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1053
0.1176
0.125
0.1
0.1429
0.1034
0.1053
0.1
0.1852
0.1818
0.1667
0.2
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1429
0.1075
0.1176
0.1053
0.1
0.1
0.1
0.1
0.1

0.1
0.15
0.1667
0.1
0.125
0.1818
0.1111
0.1
0.1538
0.1
0.6
0.1
0.1
0.1
0.2
0.1818
0.1
0.1111
0.1053
0.1
0.5714
0.2778
0.1429
0.2727
0.1
0.1
0.2143
0.2727
0.25
0.2727
0.1
0.1
0.1
0.1
0.1667
0.15
0.1667
0.1176
0.1333
0.2
0.3
0.1
0.2
0.1
0.125
0.2143
0.1739
0.1818
0.1176
0.1176
0.1538
0.1579
0.125
0.1333
0.1538
0.1579
0.1429
0.1
0.2308
0.1667
0.1364
0.1
0.1
0.1111
0.1053
0.1333
0.1667
0.2
0.2
0.1818
0.1346
0.1111
0.1538
0.1111
0.1333
0.1765
0.3667
0.7
0.2667
0.2
0.1
0.2143
0.1818
0.1304
0.1
0.1176
0.1
0.3077
0.9286
0.1667
0.1429
0.12
0.1429
0.125
0.1
0.1

2
2
4
2
6
2
2
2
6
2
5
3
2
2
2
7
2
3
2
3
14
16
2
4
2
2
2
2
6
6
7
2
2
2
2
9
4
2
3
2
2
2
4
2
3
13
11
4
3
4
3
2
2
2
7
2
5
2
5
11
3
2
2
2
2
3
3
7
10
2
8
3
2
5
3
5
11
8
4
4
2
6
2
8
2
2
2
5
12
4
3
3
2
7
2
2

2
2
2
2
2
2
2
2
3
2
4
2
2
2
2
4
2
2
2
2
14
10
2
2
2
2
2
2
3
4
2
2
2
2
2
2
2
2
3
2
2
2
3
2
2
4
6
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
3
2
4
5
2
2
2
2
3
2
3
10
8
3
2
2
3
2
2
2
2
2
2
9
3
2
2
2
2
2
2

[10,10]
[16,20]
[12,15]
[10,10]
[16,18]
[10,11]
[10,18]
[10,10]
[13,25]
[10,10]
[12,30]
[10,10]
[10,10]
[10,10]
[10,21]
[12,17]
[10,20]
[10,18]
[10,19]
[10,10]
[15,85]
[10,37]
[10,14]
[11,20]
[10,10]
[10,10]
[10,15]
[11,15]
[12,20]
[11,18]
[20,50]
[10,10]
[10,10]
[10,10]
[10,12]
[10,20]
[10,13]
[17,18]
[15,30]
[15,42]
[10,12]
[10,11]
[10,11]
[10,10]
[10,24]
[14,42]
[18,65]
[10,33]
[10,17]
[10,17]
[10,13]
[14,19]
[16,34]
[15,29]
[13,28]
[10,19]
[14,16]
[10,10]
[21,26]
[12,30]
[18,22]
[10,10]
[20,20]
[10,18]
[10,19]
[10,19]
[10,12]
[10,18]
[10,37]
[17,22]
[32,52]
[18,21]
[13,14]
[18,29]
[15,19]
[10,19]
[10,33]
[10,24]
[12,18]
[20,25]
[10,10]
[10,15]
[10,11]
[20,23]
[10,10]
[10,17]
[10,20]
[13,14]
[13,134]
[17,26]
[14,19]
[20,25]
[10,14]
[10,16]
[10,10]
[10,10]

TableS10

chr11:783553
chr19:6392862
chr14:99834934
chr12:97519606
chr3:142177823
chr3:142178168
chr3:142178523
chr3:142179474
chr3:142179501
chr3:142180718
chr8:23484816
chr8:23485230
chr19:19079768
chr11:64906534
chr5:110126597
chr3:48643688
chr3:48638405
chr9:130144397
chr9:130144398
chr9:130144453
chr9:130144454
chr19:63702079
chr6:44308691
chr6:44306069
chr6:44301776
chr6:44301779
chr22:22567409
chr22:22567411
chr22:22567412
chr4:41783780
chr4:41783830
chr6:88278411
chr17:45133802
chr6:44330143
chr6:44330144
chr6:8373210
chr7:133634834
chr7:133635543
chr11:45789026
chr1:67241316
chr21:42874066
chr11:118400313
chr11:118405349
chr12:44869108
chr12:44865532
chr12:44866431
chr17:76864428
chr17:76839651
chr17:76834368
chr12:45046995
chr12:45046994
chr1:152198283
chr17:68154824
chr11:47393418
chr8:22333086
chr8:22321881
chr8:22335911
chr8:22335912
chr19:2683575
chr4:103401953
chr14:68997542
chr14:68998166
chr3:127208179
chr11:57018067
chr11:56948064
chr11:56948067
chr11:56945044
chr11:56931742
chr19:10609707
chr2:27764390
chr2:27771134
chr3:27390757
chr3:14484623
chr13:28983497
chr13:28984192
chr13:28984975
chr16:86430826
chr16:86424074
chr16:66888213
chr16:66858121
chr16:66866097
chr14:22313165
chr14:22313163
chr1:27308608
chr20:47865033
chr17:30796721
chr18:12417110
chr15:57011912
chr15:57011905
chr15:56972482
chr15:56958590
chr5:159772046
chr5:159761412
chr4:146694412
chr18:43620821
chr18:46859750

SLC25A22
SLC25A23
SLC25A29
SLC25A3
SLC25A36
SLC25A36
SLC25A36
SLC25A36
SLC25A36
SLC25A36
SLC25A37
SLC25A37
SLC25A42
SLC25A45
SLC25A46
SLC26A6
SLC26A6
SLC27A4
SLC27A4
SLC27A4
SLC27A4
SLC27A5
SLC29A1
SLC29A1
SLC29A1
SLC29A1
SLC2A11
SLC2A11
SLC2A11
SLC30A9
SLC30A9
SLC35A1
SLC35B1
SLC35B2
SLC35B2
SLC35B3
SLC35B4
SLC35B4
SLC35C1
SLC35D1
SLC37A1
SLC37A4
SLC37A4
SLC38A1
SLC38A1
SLC38A1
SLC38A10
SLC38A10
SLC38A10
SLC38A2
SLC38A2
SLC39A1
SLC39A11
SLC39A13
SLC39A14
SLC39A14
SLC39A14
SLC39A14
SLC39A3
SLC39A8
SLC39A9
SLC39A9
SLC41A3
SLC43A1
SLC43A3
SLC43A3
SLC43A3
SLC43A3
SLC44A2
SLC4A1AP
SLC4A1AP
SLC4A7
SLC6A6
SLC7A1
SLC7A1
SLC7A1
SLC7A5
SLC7A5
SLC7A6
SLC7A6
SLC7A6
SLC7A7
SLC7A7
SLC9A1
SLC9A8
SLFN13
SLMO1
SLTM
SLTM
SLTM
SLTM
SLU7
SLU7
SMAD1
SMAD2
SMAD4

coding_exon
mixed
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR5
UTR3
coding_exon
UTR3
mixed
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR5
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
mixed
UTR3
mixed
UTR3
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
mixed
UTR5
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3

ENST00000320230:FtoS;
ENST00000359232:KtoQ;

ENST00000290075:YtoD;
ENST00000290075:StoP;
ENST00000318596:HtoR;ENST00000454460:HtoR;

ENST00000337000:VtoA;ENST00000358747:VtoA;ENST00000383733:VtoA;ENST00

ENST00000263093:VtoA;ENST00000415559:VtoA;
ENST00000313248:LtoP;ENST00000371708:LtoP;ENST00000371713:LtoP;ENST0000

ENST00000314134:LtoH;ENST00000442528:LtoH;ENST00000456334:LtoH;

ENST00000354341:WtoR;ENST00000398637:LtoS;ENST00000439706:LtoS;

ENST00000288439:VtoG;ENST00000374759:VtoG;
ENST00000288439:MtoL;
ENST00000256689:AtoD;ENST00000395444:AtoD;

ENST00000289952:LtoP;ENST00000359741:LtoP;ENST00000381237:LtoP;

ENST00000352187:TtoP;ENST00000395123:TtoP;ENST00000395124:TtoP;ENST000
ENST00000352187:TtoP;ENST00000395123:TtoP;ENST00000395124:TtoP;ENST000
ENST00000352187:StoP;ENST00000395123:StoP;ENST00000395124:StoP;ENST000
ENST00000335757:VtoG;ENST00000407327:VtoG;

ENST00000360861:LtoR;ENST00000454876:LtoR;

ENST00000261622:StoP;

ENST00000285850:LtoV;ENST00000397528:LtoV;ENST00000397529:LtoV;ENST000
ENST00000263980:MtoT;ENST00000374086:MtoT;
ENST00000285013:RtoK;
ENST00000336990:MtoR;ENST00000430510:MtoR;ENST00000440960:MtoR;
ENST00000249735:DtoG;ENST00000380516:DtoG;
ENST00000249735:DtoE;ENST00000380516:DtoE;

ENST00000297151:VtoA;
ENST00000302085:EtoK;ENST00000394092:EtoK;

127

+
+
+
+
+
+
+
+
+
+

+
+
+
+

+
+
+
+
+
+
+
+
+
+

+
+
+
+
+

+
+

+
+
+

+
+
+

TtoC
AtoG
AtoC
AtoG
AtoG
GtoA
TtoA
CtoA
AtoG
TtoC
TtoG
TtoC
AtoG
TtoA
GtoA
TtoC
CtoG
GtoT
AtoC
CtoA
AtoG
TtoC
TtoC
TtoC
GtoC
CtoG
TtoA
GtoA
GtoA
AtoT
CtoA
TtoC
TtoC
TtoC
TtoA
TtoC
AtoG
AtoG
TtoA
TtoG
TtoC
TtoC
AtoG
TtoC
GtoA
AtoG
TtoG
AtoT
TtoG
CtoA
TtoG
AtoG
TtoG
CtoA
TtoC
GtoA
GtoC
AtoT
TtoA
AtoG
GtoT
GtoA
TtoG
GtoA
AtoC
AtoC
TtoC
AtoC
TtoG
AtoG
AtoG
TtoC
TtoG
CtoG
TtoA
AtoC
TtoC
AtoG
GtoA
GtoT
CtoA
CtoG
CtoA
TtoC
GtoA
GtoA
TtoG
AtoG
TtoA
AtoG
TtoC
TtoC
TtoC
GtoA
TtoC
AtoG

0.1
0.1029
0.1
0.1471
0.1538
0.1
0.1
0.1053
0.1
0.1111
0.1
0.1
0.1
0.1667
0.1034
0.1
0.1
0.7692
0.8182
0.9091
0.9643
0.1
0.1
0.1176
0.1
0.1429
0.5
0.2308
0.2308
0.1667
0.1739
0.1
0.12
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.12
0.1
0.1176
0.1
0.1
0.1
0.1071
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1667
0.1
0.5417
0.1
0.1
0.1127
0.1
0.12
0.1169
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1176
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1765
0.1
0.1
0.1
0.1

0.1333
0.2273
0.3636
0.2727
0.1538
0.2222
0.1
0.1667
0.1
0.15
0.1538
0.1905
0.1
0.2
0.1579
0.1
0.1
1
1
1
1
0.2
0.2
0.125
0.1111
0.2
0.7222
0.6
0.3077
0.1818
0.25
0.1
0.1538
0.3636
0.1333
0.1
0.1111
0.1538
0.1
0.1
0.1429
0.2727
0.1429
0.1
0.2143
0.1176
0.2
0.1875
0.1
0.2
0.2
0.1154
0.2
0.1
0.1818
0.1
0.1111
0.1176
0.1
0.2
0.2
0.8125
0.1
0.1
0.2041
0.1017
0.2174
0.25
0.2308
0.1
0.1818
0.1538
0.2
0.1429
0.1818
0.1154
0.1818
0.1
0.1
0.1667
0.1538
0.1111
0.1111
0.1818
0.1
0.1
0.1818
0.1538
0.1176
0.125
0.1875
0.1818
0.2222
0.1
0.1579
0.1111

3
5
2
9
6
2
3
2
3
4
2
2
2
2
4
2
2
8
8
15
14
6
4
3
2
2
6
12
5
3
4
2
10
11
5
2
2
3
3
2
2
6
5
2
3
2
4
4
2
2
3
8
2
3
4
3
4
4
2
3
3
2
3
3
8
4
9
4
6
2
3
2
2
4
2
2
2
2
2
6
3
5
5
2
2
3
2
2
4
2
8
3
6
3
3
3

2
5
2
6
2
2
2
2
2
2
2
2
2
2
2
2
2
8
8
15
14
3
2
2
2
2
6
12
5
3
2
2
3
9
3
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
4
2
5
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
3
2
2
2

[10,15]
[18,68]
[10,11]
[11,34]
[13,13]
[10,18]
[10,10]
[18,19]
[10,10]
[18,20]
[10,13]
[10,21]
[10,10]
[10,18]
[19,29]
[10,10]
[10,20]
[11,19]
[10,19]
[33,434]
[38,431]
[10,20]
[10,10]
[16,17]
[10,18]
[10,14]
[13,52]
[10,33]
[10,17]
[11,12]
[12,23]
[10,10]
[14,25]
[11,20]
[10,16]
[10,10]
[10,10]
[10,13]
[10,10]
[10,10]
[14,26]
[11,20]
[17,21]
[10,10]
[10,14]
[10,17]
[15,28]
[10,16]
[10,10]
[10,10]
[10,10]
[26,30]
[10,10]
[10,10]
[10,11]
[10,10]
[10,18]
[17,19]
[10,10]
[10,12]
[15,20]
[16,24]
[10,10]
[10,10]
[49,71]
[10,59]
[15,62]
[32,77]
[13,21]
[10,10]
[10,12]
[10,13]
[10,10]
[14,17]
[10,11]
[10,26]
[11,17]
[10,10]
[10,10]
[10,18]
[13,20]
[18,19]
[18,20]
[10,11]
[10,10]
[10,10]
[10,11]
[10,13]
[10,17]
[16,17]
[10,23]
[11,17]
[10,27]
[10,10]
[10,19]
[10,18]

TableS10

chr4:144693779
chr2:217005833
chr22:22506685
chr3:47603812
chr12:54843803
chr12:54842514
chr12:54843337
chr12:48768597
chr12:48780648
chr17:36038551
chr9:105898288
chr9:105941952
chr9:105942547
chr10:112350812
chr3:161603194
chr9:72152671
chr9:72128240
chr2:17748038
chr2:17748009
chr2:17741064
chr14:90998922
chr14:91026850
chr14:91006934
chr14:91012031
chr2:55648888
chr2:55679492
chr16:18736292
chr16:18724828
chr16:18726245
chr16:18726406
chr1:154502445
chr17:2150225
chr17:2149529
chr17:1910694
chr1:181777857
chr1:181778011
chr1:181787775
chr10:112047322
chr10:112045103
chr12:52862127
chr7:98483363
chr17:1633184
chr2:73304614
chr9:15454515
chr9:15455450
chr9:138406795
chr9:138396321
chr7:127519882
chr17:44362774
chr17:44362776
chr1:28778910
chr1:37775939
chr1:37790860
chr16:11680101
chr11:93106225
chr11:93114221
chr9:138739019
chr1:28707203
chr6:86443929
chr6:86444573
chr6:86444628
chr3:43364348
chr2:96307286
chr2:96314648
chr12:122516477
chr19:54298188
chr19:45963119
chr19:45948962
chr20:2391822
chr20:16669826
chr22:23298086
chr22:23298088
chr1:202099460
chr1:202099466
chr1:202099468
chr1:202099467
chr1:202099416
chr12:94783990
chr14:77253732
chr15:62222571
chr7:26378143
chr17:43554582
chr6:86313628
chr11:64562788
chr11:130251712
chr15:62235061
chr15:62235089
chr15:62235578
chr4:186504735
chr4:186509688
chr1:149936600
chr1:149937582
chr1:149937718
chr16:12062956
chr16:12570807
chr16:12571932

SMARCA5
SMARCAL1
SMARCB1
SMARCC1
SMARCC2
SMARCC2
SMARCC2
SMARCD1
SMARCD1
SMARCE1
SMC2
SMC2
SMC2
SMC3
SMC4
SMC5
SMC5
SMC6
SMC6
SMC6
SMEK1
SMEK1
SMEK1
SMEK1
SMEK2
SMEK2
SMG1
SMG1
SMG1
SMG1
SMG5
SMG6
SMG6
SMG6
SMG7
SMG7
SMG7
SMNDC1
SMNDC1
SMUG1
SMURF1
SMYD4
SMYD5
SNAPC3
SNAPC3
SNAPC4
SNAPC4
SND1
SNF8
SNF8
SNHG12
SNIP1
SNIP1
SNN
SNORA32
SNORA32
SNORA43
SNORA73A
SNORD50B
SNORD50B
SNORD50B
SNRK
SNRNP200
SNRNP200
SNRNP35
SNRNP70
SNRPA
SNRPA
SNRPB
SNRPB2
SNRPD3
SNRPD3
SNRPE
SNRPE
SNRPE
SNRPE
SNRPE
SNRPF
SNW1
SNX1
SNX10
SNX11
SNX14
SNX15
SNX19
SNX22
SNX22
SNX22
SNX25
SNX25
SNX27
SNX27
SNX27
SNX29
SNX29
SNX29

coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
mixed
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR5
mixed
mixed
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR5
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
coding_exon
UTR3
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3

ENST00000283131:KtoE;
ENST00000357276:EtoD;ENST00000358207:EtoD;

ENST00000361804:TtoP;
ENST00000344722:KtoE;ENST00000357388:KtoE;ENST00000360111:KtoE;ENST000
ENST00000361138:LtoR;
ENST00000361138:DtoE;
ENST00000351948:DtoA;ENST00000381272:DtoA;ENST00000402989:DtoA;ENST00
ENST00000351948:AtoS;ENST00000381272:AtoS;ENST00000402989:AtoS;ENST000
ENST00000337238:LtoP;ENST00000417249:LtoP;ENST00000417427:LtoP;ENST0000
ENST00000337238:KtoN;ENST00000417249:KtoN;ENST00000417427:KtoN;ENST00
ENST00000337238:CtoS;ENST00000417249:CtoS;ENST00000417427:CtoS;ENST000

ENST00000389467:VtoA;ENST00000446231:VtoA;

ENST00000361813:StoP;
ENST00000263073:VtoD;
ENST00000263073:GtoV;
ENST00000347615:VtoA;ENST00000367537:VtoA;ENST00000367539:VtoA;ENST00

ENST00000369592:MtoV;ENST00000369603:MtoV;
ENST00000369592:EtoG;ENST00000369603:EtoG;

ENST00000305513:AtoD;

ENST00000298532:NtoK;
ENST00000298532:LtoR;

ENST00000296215:StoR;ENST00000436196:StoR;

ENST00000323853:EtoK;
ENST00000323853:EtoD;
ENST00000412157:GtoE;ENST00000438124:GtoE;

ENST00000303103:TtoP;ENST00000336808:HtoP;ENST00000339610:TtoP;ENST000

ENST00000367208:ItoK;ENST00000414487:ItoK;
ENST00000367208:GtoD;ENST00000414487:GtoD;
ENST00000367208:CtoG;ENST00000414487:CtoG;

ENST00000301886:QtoR;ENST00000377244:QtoR;

ENST00000306030:StoP;ENST00000323433:StoP;

128

+
+
+

+
+

+
+
+
+
+
+
+

+
+
+

+
+
+

+
+
+
+

+
+
+
+
+
+
+
+
+

+
+
+

+
+
+
+
+
+
+
+
+
+
+

AtoG
GtoT
TtoC
TtoA
CtoT
TtoG
TtoA
TtoA
TtoC
TtoG
TtoC
AtoG
TtoG
AtoC
AtoG
TtoG
TtoA
AtoC
GtoT
AtoG
TtoC
AtoT
TtoA
TtoA
TtoC
TtoC
TtoC
TtoC
AtoG
AtoG
TtoC
TtoA
GtoT
AtoC
TtoC
AtoG
TtoC
AtoG
AtoG
TtoC
TtoC
CtoA
TtoC
GtoA
AtoT
CtoG
TtoG
GtoA
GtoA
TtoC
TtoG
CtoA
TtoC
TtoA
CtoT
GtoC
TtoA
AtoC
TtoA
GtoA
CtoT
TtoC
GtoA
GtoC
GtoA
CtoT
GtoA
GtoT
AtoC
CtoG
TtoC
GtoA
TtoA
GtoA
TtoG
CtoG
AtoC
TtoC
TtoC
AtoC
AtoG
AtoG
AtoG
AtoG
CtoA
AtoG
AtoG
GtoA
TtoA
GtoA
TtoC
TtoG
TtoA
TtoC
TtoG
TtoC

0.1111
0.1
0.2
0.1538
0.1333
0.1111
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1538
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1364
0.1111
0.1
0.1
0.3077
0.1071
0.1071
0.15
0.1
0.1667
0.1
0.1
0.1389
0.1111
0.1818
0.1212
0.1071
0.1154
0.1
0.1176
0.1
0.1111
0.1
0.1
0.1
0.1119
0.1
0.1
0.1364
0.1
0.1304
0.2727
0.1429
0.1
0.1096
0.1
0.1
0.1667
0.1739
0.1
0.1111
0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1429
0.1
0.1333

0.125
0.1
0.3
0.4444
0.5294
0.1111
0.1
0.1111
0.1667
0.1765
0.1667
0.1
0.1
0.2143
0.1429
0.1
0.1053
0.1429
0.1818
0.1053
0.1
0.1
0.2
0.1
0.125
0.1667
0.3
0.1053
0.1
0.1429
0.1034
0.1
0.1
0.1667
0.1
0.2
0.1053
0.125
0.1
0.1
0.2
0.1
0.1111
0.1379
0.1667
0.1
0.1
0.7895
0.125
0.28
0.1538
0.1053
0.2
0.2
0.1
0.2632
0.12
0.2727
0.1707
0.3333
0.2703
0.3
0.125
0.1143
0.125
0.1
0.1538
0.1304
0.3542
0.1
0.2188
0.1667
0.125
0.3
0.4167
0.5
0.3438
0.1429
0.2
0.2
0.2
0.2
0.1
0.125
0.1333
0.2143
0.2667
0.1538
0.1053
0.2105
0.1
0.1
0.1
0.2
0.1
0.1818

4
2
3
7
2
3
2
4
4
2
3
3
3
4
7
4
2
2
2
2
3
3
4
4
3
5
5
3
2
4
4
2
2
2
3
2
3
3
5
4
2
2
3
2
4
2
2
6
4
8
5
2
2
5
2
4
6
2
11
20
21
2
5
3
7
2
2
7
3
4
9
6
9
8
2
10
13
8
3
2
3
3
2
2
3
2
4
5
6
10
2
3
4
5
2
5

2
2
3
7
2
2
2
2
3
2
3
2
2
2
4
2
2
2
2
2
2
3
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
5
2
5
2
2
2
3
2
2
2
2
5
20
20
2
2
2
4
2
2
2
2
2
4
3
2
7
2
8
12
4
3
2
2
2
2
2
2
2
3
4
2
3
2
2
2
2
2
3

[32,45]
[10,10]
[11,50]
[13,25]
[15,34]
[10,19]
[10,10]
[10,10]
[10,16]
[17,18]
[10,12]
[10,10]
[10,10]
[10,14]
[10,37]
[10,10]
[10,19]
[10,14]
[10,11]
[10,19]
[10,10]
[10,10]
[10,17]
[10,10]
[16,19]
[10,19]
[10,10]
[10,19]
[10,10]
[10,14]
[30,30]
[10,10]
[10,10]
[12,13]
[10,10]
[10,10]
[19,19]
[16,20]
[10,10]
[10,10]
[10,10]
[10,10]
[10,18]
[22,29]
[12,18]
[10,10]
[10,10]
[10,19]
[16,28]
[23,55]
[13,20]
[10,19]
[10,12]
[10,28]
[10,10]
[19,36]
[18,25]
[11,11]
[26,65]
[28,132]
[16,78]
[10,10]
[16,17]
[10,35]
[16,35]
[10,10]
[10,13]
[10,23]
[48,144]
[10,10]
[10,32]
[13,22]
[16,21]
[10,23]
[12,13]
[10,21]
[10,47]
[35,75]
[10,15]
[10,10]
[12,15]
[15,23]
[10,10]
[16,18]
[15,17]
[10,14]
[14,22]
[10,20]
[11,20]
[19,20]
[10,10]
[10,10]
[10,10]
[10,14]
[10,10]
[11,17]

TableS10

chr16:12572516
chr16:12574317
chr16:12575449
chr20:17889859
chr20:17889969
chr20:17870497
chr14:34148653
chr1:177584669
chr16:11255859
chr12:92493367
chr14:54580002
chr14:54580000
chr21:31962835
chr21:31962851
chr6:160023556
chr6:160020236
chr16:536967
chr21:33853781
chr21:33845126
chr21:33845189
chr11:121003630
chr11:121006940
chr11:121007309
chr2:39065512
chr6:21702335
chr6:21706340
chr8:10660372
chr12:52091095
chr12:52092474
chr12:52092478
chr12:52093657
chr2:231016021
chr2:230820959
chr2:230821013
chr2:230842533
chr2:230821010
chr2:230867268
chr2:230811861
chr1:118303607
chr1:118303771
chr17:4803353
chr17:46409499
chr17:46398403
chr20:47955361
chr12:48170773
chr2:201045948
chr2:200962241
chr3:52717136
chr4:177487849
chr4:177489232
chr4:177489320
chr4:177489321
chr2:28876095
chr2:28876570
chr2:28877607
chr2:28878852
chr2:28926752
chr1:16130247
chr1:16131219
chr1:16128026
chr1:16134682
chr1:16139027
chr15:42644127
chr15:42688050
chr15:42694889
chr15:42648993
chr15:63043098
chr15:63042463
chr15:63042681
chr16:88151154
chr19:53823345
chr19:53825196
chr19:55624056
chr19:55624061
chr9:90281292
chr16:28894164
chr17:45032054
chr17:45032379
chr12:51754766
chr12:51745167
chr9:130368914
chr2:54730317
chr2:54749427
chr2:54749429
chr2:54749843
chr9:93834113
chr14:77043171
chr11:18584633
chr8:126088879
chr8:126088873
chr15:43770696
chr3:144228695
chr3:144222915
chr3:144258183
chr2:45499048
chr20:35465447

SNX29
SNX29
SNX29
SNX5
SNX5
SNX5
SNX6
SOAT1
SOCS1
SOCS2
SOCS4
SOCS4
SOD1
SOD1
SOD2
SOD2
SOLH
SON
SON
SON
SORL1
SORL1
SORL1
SOS1
SOX4
SOX4
SOX7
SP1
SP1
SP1
SP1
SP100
SP140
SP140
SP140
SP140
SP140
SP140
SPAG17
SPAG17
SPAG7
SPAG9
SPAG9
SPATA2
SPATS2
SPATS2L
SPATS2L
SPCS1
SPCS3
SPCS3
SPCS3
SPCS3
SPDYA
SPDYA
SPDYA
SPDYA
SPDYA
SPEN
SPEN
SPEN
SPEN
SPEN
SPG11
SPG11
SPG11
SPG11
SPG21
SPG21
SPG21
SPG7
SPHK2
SPHK2
SPIB
SPIB
SPIN1
SPNS1
SPOP
SPOP
SPRYD3
SPRYD3
SPTAN1
SPTBN1
SPTBN1
SPTBN1
SPTBN1
SPTLC1
SPTLC2
SPTY2D1
SQLE
SQLE
SQRDL
SR140
SR140
SR140
SRBD1
SRC

UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
mixed
coding_exon
mixed
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
mixed
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
coding_exon
mixed
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
mixed
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
mixed
mixed
UTR3
UTR3
UTR3
mixed
UTR3
UTR3
coding_exon
UTR3
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
mixed
UTR3
coding_exon
UTR3

ENST00000367619:LtoQ;

ENST00000395472:TtoS;
ENST00000395472:StoI;

ENST00000337404:WtoR;ENST00000367054:WtoR;ENST00000367055:WtoR;ENST0
ENST00000219611:VtoA;ENST00000397687:VtoA;
ENST00000300278:AtoT;ENST00000321758:AtoT;ENST00000356577:AtoT;ENST000

ENST00000260197:NtoT;

ENST00000327443:VtoA;ENST00000426431:VtoA;

ENST00000343805:NtoS;ENST00000392045:NtoS;
ENST00000343805:GtoA;ENST00000392045:GtoA;
ENST00000343805:EtoG;ENST00000350136:EtoG;ENST00000392045:EtoG;
ENST00000343805:EtoA;ENST00000392045:EtoA;

ENST00000262013:NtoK;ENST00000357122:NtoK;ENST00000357804:NtoK;ENST00

ENST00000321898:KtoE;ENST00000447889:KtoE;

ENST00000375759:VtoG;
ENST00000375759:NtoS;
ENST00000375759:KtoE;

ENST00000261866:QtoR;
ENST00000261866:PtoS;ENST00000427534:PtoS;
ENST00000261866:LtoP;ENST00000427534:LtoP;

ENST00000301463:CtoW;

ENST00000333896:VtoG;ENST00000356805:VtoG;

ENST00000265896:QtoE;
ENST00000265896:GtoV;
ENST00000319822:LtoP;ENST00000397933:LtoP;ENST00000429264:LtoP;ENST0000

ENST00000263736:FtoV;

129

+
+
+

+
+
+
+
+

+
+
+
+
+
+
+

+
+

+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+

+
+
+
+
+

+
+
+
+
+
+

TtoC
AtoG
TtoA
TtoC
TtoG
AtoG
TtoC
TtoA
TtoG
GtoA
AtoT
GtoT
TtoA
TtoA
TtoC
TtoC
TtoC
GtoA
AtoG
AtoG
AtoC
AtoG
AtoT
AtoG
GtoA
CtoG
TtoC
TtoC
TtoC
CtoA
AtoC
TtoC
AtoG
GtoC
AtoG
AtoC
GtoA
TtoC
AtoG
AtoG
AtoT
TtoG
TtoG
AtoC
AtoG
AtoC
TtoC
AtoG
CtoT
AtoG
AtoG
AtoG
AtoG
AtoG
TtoC
AtoG
AtoC
TtoG
AtoG
AtoG
TtoC
AtoG
AtoG
CtoT
TtoC
AtoT
CtoT
TtoC
TtoA
TtoA
GtoA
AtoC
TtoC
GtoA
TtoG
TtoG
TtoC
GtoA
TtoG
TtoA
GtoT
TtoG
AtoG
AtoG
TtoA
TtoC
AtoT
GtoA
CtoG
GtoT
TtoA
TtoC
GtoT
TtoC
TtoG
TtoC

0.1
0.1
0.1
0.1
0.1333
0.1333
0.1
0.1
0.2
0.1
0.1
0.1
0.1091
0.1053
0.1
0.1538
0.1
0.963
0.1071
0.1026
0.1026
0.5968
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1538
0.125
0.1154
0.1702
0.1
0.1
0.1
0.1
0.1
0.1
0.1159
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1529
0.2667
0.5455
0.1
0.1176
0.1111
0.1
0.1
0.1667
0.1
0.1
0.1
0.1
0.1
0.1111
0.1111
0.1304
0.4355
0.1429
0.1176
0.1053
0.1
0.1
0.1176
0.1
0.1
0.1
0.1053
0.1176
0.15
0.1333
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.3
0.3
0.3
0.1
0.1
0.1
0.1
0.1
0.1

0.1111
0.1333
0.1111
0.1
0.2
0.1667
0.1
0.1
0.2857
0.1
0.1333
0.125
0.2121
0.2143
0.1429
0.1667
0.1
1
0.1154
0.1667
0.1739
0.6145
0.1538
0.1
0.4286
0.1364
0.1
0.1667
0.2
0.1
0.3
0.2222
0.1765
0.2308
0.1333
0.2115
0.1111
0.1765
0.2308
0.1538
0.1183
0.1053
0.1
0.1
0.3077
0.1
0.1429
0.1333
0.1667
0.6667
0.4
0.6364
0.1667
0.2857
0.1538
0.1875
0.1
0.4286
0.125
0.1053
0.1176
0.1
0.1579
0.1333
0.1429
0.2
0.5263
0.1818
0.1667
0.1579
0.1818
0.1
0.2
0.2143
0.1
0.2143
0.119
0.1212
0.1786
0.1818
0.1667
0.1538
0.2
0.1538
0.1875
0.1
0.1176
0.3077
0.5
0.6364
0.1905
0.1
0.15
0.1
0.1176
0.1

2
4
2
4
3
4
3
5
2
2
2
2
11
13
7
7
2
16
8
8
3
2
3
2
4
2
2
5
11
3
2
9
4
4
4
6
7
5
6
4
3
2
2
3
2
2
4
6
2
14
3
2
4
6
5
4
2
4
4
6
3
6
7
7
2
4
2
3
4
9
6
2
6
2
2
3
7
7
3
4
2
2
6
6
8
3
4
2
3
8
4
2
3
3
3
2

2
2
2
2
2
2
2
2
2
2
2
2
3
5
2
2
2
16
2
4
3
2
2
2
4
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
12
3
2
2
2
2
3
2
2
2
2
3
2
2
2
2
2
2
2
3
4
2
2
3
2
2
2
3
2
2
2
2
2
3
3
3
2
2
2
3
8
2
2
2
2
2
2

[10,18]
[15,20]
[10,10]
[10,10]
[10,15]
[13,15]
[10,10]
[10,11]
[11,14]
[10,10]
[10,15]
[10,16]
[33,55]
[14,30]
[14,30]
[12,13]
[10,10]
[18,92]
[26,28]
[39,60]
[17,39]
[62,83]
[10,13]
[10,10]
[10,20]
[10,22]
[10,10]
[12,17]
[10,20]
[10,10]
[10,13]
[19,32]
[26,52]
[13,47]
[10,15]
[16,52]
[10,27]
[10,18]
[10,13]
[10,13]
[69,94]
[10,19]
[10,10]
[10,10]
[10,13]
[10,10]
[10,14]
[15,20]
[10,12]
[12,85]
[10,15]
[11,11]
[10,12]
[14,18]
[18,27]
[10,16]
[10,10]
[14,18]
[10,16]
[10,19]
[10,17]
[10,20]
[10,20]
[10,15]
[14,18]
[10,23]
[38,62]
[11,14]
[13,18]
[18,28]
[10,11]
[10,10]
[10,35]
[14,20]
[10,10]
[10,14]
[17,42]
[17,33]
[20,28]
[11,15]
[10,12]
[10,13]
[16,20]
[14,19]
[11,16]
[10,10]
[10,17]
[10,13]
[10,14]
[10,21]
[10,21]
[10,10]
[10,20]
[10,10]
[10,18]
[10,10]

TableS10

chr20:35467045
SRC
chr20:35467047
SRC
chr5:6705099
SRD5A1
chr6:43255121
SRF
chr6:43255183
SRF
chr6:43256221
SRF
chr5:121384079
SRFBP1
chr3:9401522
SRGAP3
chr10:70534516
SRGN
chr10:70534567
SRGN
chr7:87673614
SRI
chr1:11037245
SRM
chr1:11037319
SRM
chr15:38115530
SRP14
chr5:112226171
SRP19
chr5:112231330
SRP19
chr14:34568095
SRP54
chr6:35946141
SRPK1
chr7:104574277
SRPK2
chr7:104553953
SRPK2
chr7:104570960
SRPK2
chr7:104539879
SRPK2
chr7:104541012
SRPK2
chr11:125638087
SRPR
chr17:2173206
SRR
chr22:25216103
SRRD
chr16:2753090
SRRM2
chr16:2761381
SRRM2
chr20:575645
SRXN1
chr7:141096703
SSBP1
chr7:141084636
SSBP1
chr12:107705168
SSH1
chr6:7243173
SSR1
chr6:7232801
SSR1
chr6:7234118
SSR1
chr6:7234323
SSR1
chr6:7234754
SSR1
chr6:7234755
SSR1
chr6:7234957
SSR1
chr1:154245469
SSR2
chr3:157741562
SSR3
chr3:157742482
SSR3
chr3:157743528
SSR3
chr11:56850049
SSRP1
chr11:56850051
SSRP1
chr22:39576817
ST13
chr22:39566639
ST13
chr22:39576789
ST13
chr22:39556794
ST13
chr22:39570797
ST13
chr22:39556845
ST13
chr22:39556846
ST13
chr22:39576820
ST13
chr22:39556849
ST13
chr22:39561775
ST13
chr22:39556843
ST13
chr22:39556852
ST13
chr22:39555618
ST13
chr22:39566612
ST13
chr22:39561577
ST13
chr22:39558575
ST13
chr22:39561567
ST13
chr22:39556790
ST13
chr22:39556853
ST13
chr22:39558576
ST13
chr22:39561776
ST13
chr22:39570792
ST13
chr22:39574251
ST13
chr22:39576803
ST13
chr22:39576824
ST13
chr22:39582470
ST13
chr16:68971437
ST3GAL2
chr1:44168563
ST3GAL3
chr3:99975517
ST3GAL6
chr3:99989678
ST3GAL6
chr3:188277458
ST6GAL1
chr3:188279021
ST6GAL1
chr9:129687425 ST6GALNAC6
chr7:116657174
ST7
chr5:100249964
ST8SIA4
chr5:100175732
ST8SIA4
chr3:52533448
STAB1
chr2:73943437
STAMBP
chr2:73909693
STAMBP
chr10:90672089
STAMBPL1
chr4:68155059
STAP1
chr19:4276419
STAP2
chr11:72146577
STARD10
chr11:72181570
STARD10
chr7:38220534
STARD3NL
chr5:110864628
STARD4
chr5:110861974
STARD4
chr2:96214907
STARD7
chr2:96215657
STARD7
chr15:40774217
STARD9
chr15:40774218
STARD9

UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
mixed
coding_exon
coding_exon
coding_exon
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR5
UTR3
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR5
coding_exon
UTR3
coding_exon
coding_exon
UTR5
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon

ENST00000282999:ItoV;ENST00000445150:ItoV;
ENST00000216774:FtoI;
ENST00000357311:EtoG;ENST00000393651:EtoG;ENST00000457338:EtoG;ENST000

ENST00000215917:StoP;
ENST00000301740:StoP;ENST00000382301:StoP;

ENST00000244763:QtoH;ENST00000397511:QtoH;ENST00000462112:QtoH;ENST0

ENST00000216218:VtoL;
ENST00000216218:TtoS;
ENST00000216218:Sto*;
ENST00000216218:QtoR;
ENST00000216218:NtoY;
ENST00000216218:KtoR;
ENST00000216218:KtoE;
ENST00000216218:KtoE;
ENST00000216218:ItoV;
ENST00000216218:ItoV;
ENST00000216218:EtoK;
ENST00000216218:EtoK;
ENST00000216218:Eto*;
ENST00000216218:DtoH;
ENST00000216218:CtoR;
ENST00000216218:CtoG;
ENST00000216218:AtoD;

ENST00000265261:KtoR;ENST00000394162:NtoS;ENST00000468553:KtoR;ENST000

ENST00000231461:StoN;ENST00000451528:StoN;

ENST00000314714:PtoR;ENST00000424810:PtoR;
ENST00000334805:KtoE;
ENST00000009041:YtoN;ENST00000396013:YtoN;ENST00000434197:YtoN;
ENST00000296632:VtoA;ENST00000455172:VtoA;

ENST00000290607:YtoN;
ENST00000290607:YtoC;

130

+
+
+
+
+
+
+

+
+

+
+
+

+
+
+
+

+
+

+
+
+
+
+

+
+
+
+
+

+
+

TtoC
CtoT
AtoG
AtoG
TtoC
TtoA
AtoG
AtoT
TtoA
AtoG
TtoG
TtoC
AtoC
CtoA
AtoG
TtoA
TtoA
TtoC
AtoG
TtoC
GtoA
AtoG
TtoC
AtoG
TtoC
TtoC
TtoC
TtoA
AtoG
AtoG
AtoG
TtoC
AtoC
TtoG
TtoA
TtoG
AtoT
GtoA
GtoC
AtoG
AtoG
TtoC
TtoG
TtoC
AtoG
GtoT
AtoT
CtoA
AtoG
AtoT
AtoG
AtoG
AtoG
AtoG
AtoG
GtoA
GtoA
GtoT
GtoC
TtoC
TtoG
CtoA
GtoA
AtoG
CtoA
CtoT
GtoA
TtoC
TtoC
TtoG
CtoT
TtoG
AtoG
AtoG
TtoA
GtoT
TtoC
TtoC
AtoC
GtoA
TtoG
AtoG
AtoG
GtoA
GtoA
TtoG
CtoG
AtoG
CtoA
TtoA
TtoC
TtoG
TtoC
CtoG
TtoA
AtoG

0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1091
0.1047
0.1
0.1
0.1
0.1034
0.1
0.1
0.1
0.1
0.1
0.1176
0.1176
0.1
0.1
0.1429
0.1
0.1
0.1071
0.1
0.1176
0.1538
0.1765
0.1579
0.1
0.1111
0.1111
0.1053
0.1034
0.1429
0.1
0.1034
0.1
0.1
0.125
0.1
0.1
0.1
0.1818
0.1
0.1
0.1
0.2
0.1765
0.1111
0.1111
0.1053
0.1
0.1538
0.1333
0.1
0.1053
0.1
0.1538
0.125
0.2
0.1
0.1
0.1053
0.1333
0.1
0.1
0.1
0.1
0.1111
0.1053
0.1176
0.1
0.1
0.1667
0.2941
0.1111
0.1
0.1
0.1
0.1
0.1429
0.2727
0.1
0.1
0.1
0.1111
0.1
1
1

0.1818
0.1429
0.1
0.1
0.1
0.1667
0.1818
0.2
0.1789
0.2667
0.2727
0.1111
0.2424
0.1429
0.1176
0.2222
0.1429
0.1786
0.1667
0.1538
0.1034
0.1
0.1818
0.1875
0.1176
0.1429
0.1538
0.1429
0.1
0.3171
0.1176
0.125
0.5526
0.2222
0.1818
0.1429
0.1429
0.1538
0.8636
0.2
0.2
0.2727
0.1071
0.2
0.1333
0.1579
0.1
0.1
0.1622
0.2
0.2
0.2222
0.1
0.2
0.8
0.2
0.1667
0.1111
0.2
0.2222
0.2222
0.2308
0.1765
0.2917
0.2
0.8
0.6364
0.1111
0.1
0.2
0.35
0.2143
0.2143
0.1333
0.1
0.2667
0.1333
0.3636
0.1111
0.2
0.1667
0.3333
0.1176
0.1
0.1
0.1
0.1
0.2
0.6
0.1053
0.1875
0.1818
0.15
0.1
1
1

3
2
3
2
2
7
2
2
16
5
3
8
4
6
5
3
10
5
7
6
2
3
8
10
3
3
2
11
2
11
3
3
4
4
8
4
6
2
10
3
4
4
6
2
4
3
3
2
8
2
8
11
9
7
2
4
13
5
2
2
2
2
5
10
4
2
4
3
6
3
2
2
3
2
3
7
3
6
3
2
3
3
8
2
2
2
4
2
2
3
5
10
4
3
5
6

2
2
2
2
2
4
2
2
7
3
2
2
3
2
2
2
3
2
3
3
2
2
3
5
2
2
2
5
2
8
2
2
3
2
2
2
3
2
9
3
3
2
2
2
3
2
2
2
4
2
4
5
2
2
2
2
4
2
2
2
2
2
3
4
3
2
3
2
2
2
2
2
2
2
2
5
2
2
2
2
2
3
3
2
2
2
2
2
2
2
2
4
2
2
5
6

[11,17]
[10,14]
[10,10]
[10,10]
[10,10]
[10,25]
[10,11]
[10,10]
[57,364]
[10,15]
[10,11]
[28,58]
[76,100]
[10,14]
[11,17]
[10,20]
[28,33]
[10,28]
[10,24]
[10,13]
[10,29]
[10,10]
[11,17]
[16,54]
[10,34]
[10,14]
[13,14]
[16,37]
[10,10]
[13,43]
[17,20]
[16,17]
[13,68]
[10,17]
[11,19]
[10,14]
[14,18]
[13,18]
[19,148]
[10,29]
[10,21]
[10,22]
[28,32]
[10,20]
[10,20]
[16,19]
[10,10]
[10,10]
[18,37]
[10,11]
[10,18]
[10,18]
[10,20]
[10,16]
[10,17]
[11,19]
[18,24]
[19,27]
[10,15]
[10,13]
[10,15]
[10,13]
[18,19]
[21,30]
[10,13]
[10,17]
[10,18]
[10,10]
[10,20]
[10,19]
[15,20]
[30,42]
[10,14]
[10,15]
[10,10]
[12,20]
[15,19]
[11,17]
[18,40]
[10,16]
[12,18]
[16,18]
[17,18]
[10,10]
[10,10]
[10,10]
[10,10]
[10,14]
[10,11]
[10,19]
[10,16]
[10,21]
[20,27]
[10,10]
[11,15]
[10,15]

TableS10

chr15:40799948
chr2:191562622
chr2:191548543
chr2:191548548
chr12:55031383
chr12:55036254
chr12:55023940
chr12:55029217
chr12:55040109
chr17:37720748
chr17:37720749
chr17:37604972
chr17:37605808
chr17:37607201
chr12:55784520
chr12:55784517
chr20:47163518
chr20:47163519
chr8:74814651
chr5:172676993
chr1:47488521
chr1:47488535
chr1:47488759
chr11:4070486
chr5:171403227
chr19:1169495
chr2:196709057
chr2:242083263
chr20:2076920
chr6:36572509
chr12:27368333
chr20:43139440
chr1:36579878
chr1:26099639
chr1:26099643
chr9:123143263
chr9:35089897
chr9:35089901
chr2:201960891
chr9:124911853
chr9:124927236
chr19:51923097
chr19:51914761
chr19:51914873
chr3:31640336
chr3:31641527
chr3:31654084
chr1:28021329
chr1:28022441
chr1:28023332
chr20:56686042
chr20:56686362
chr9:101772026
chr4:4472476
chr11:62349350
chr11:62348609
chr1:179209341
chr6:132821017
chr6:132821264
chr7:75463606
chr2:84530347
chr2:84504190
chr3:67651413
chr12:117338634
chr17:70682473
chr17:70682470
chr17:70682467
chr17:70682477
chr17:70688860
chr17:70688861
chr17:70682469
chr17:70682472
chr17:70688759
chr17:70675650
chr17:70690580
chr17:70690582
chr19:44655806
chr19:44651248
chr17:24037503
chr2:27729555
chr9:135208500
chr9:135218264
chr9:135219393
chr9:135187707
chr9:113843279
chr10:14978886
chr10:14984422
chr10:14983226
chr10:14984472
chr11:67689887
chr17:27345710
chr17:27351751
chr11:22801178
chr11:9728955
chr11:9729191
chr11:9729192

STARD9
STAT1
STAT1
STAT1
STAT2
STAT2
STAT2
STAT2
STAT2
STAT3
STAT3
STAT5B
STAT5B
STAT5B
STAT6
STAT6
STAU1
STAU1
STAU2
STC2
STIL
STIL
STIL
STIM1
STK10
STK11
STK17B
STK25
STK35
STK38
STK38L
STK4
STK40
STMN1
STMN1
STOM
STOML2
STOML2
STRADB
STRBP
STRBP
STRN4
STRN4
STRN4
STT3B
STT3B
STT3B
STX12
STX12
STX12
STX16
STX16
STX17
STX18
STX5
STX5
STX6
STX7
STX7
STYXL1
SUCLG1
SUCLG1
SUCLG2
SUDS3
SUMO2
SUMO2
SUMO2
SUMO2
SUMO2
SUMO2
SUMO2
SUMO2
SUMO2
SUMO2
SUMO2
SUMO2
SUPT5H
SUPT5H
SUPT6H
SUPT7L
SURF1
SURF4
SURF4
SURF6
SUSD1
SUV39H2
SUV39H2
SUV39H2
SUV39H2
SUV420H1
SUZ12
SUZ12
SVIP
SWAP70
SWAP70
SWAP70

UTR3
coding_exon
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR5
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
mixed
mixed
UTR3
UTR3
UTR3
mixed
mixed
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
mixed
mixed
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR5
UTR5
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3

ENST00000361099:LtoR;ENST00000392322:LtoR;ENST00000392323:LtoR;ENST000

ENST00000314128:NtoH;
ENST00000314128:GtoC;ENST00000418572:GtoC;

ENST00000300134:QtoH;ENST00000454075:QtoH;

ENST00000326873:KtoE;ENST00000405031:KtoE;

ENST00000295770:LtoP;

ENST00000373939:KtoE;ENST00000373943:KtoE;

ENST00000294179:VtoA;ENST00000377897:VtoA;ENST00000394690:VtoA;

ENST00000307227:QtoR;ENST00000492795:QtoR;ENST00000493112:QtoR;
ENST00000420826:QtoR;
ENST00000420826:PtoQ;
ENST00000420826:ItoN;
ENST00000420826:GtoR;
ENST00000314523:NtoD;ENST00000420826:NtoD;
ENST00000314523:EtoD;ENST00000420826:EtoD;

ENST00000359191:QtoH;ENST00000378524:QtoH;ENST00000402194:QtoH;ENST0
ENST00000314616:LtoQ;

ENST00000313519:WtoC;ENST00000354919:WtoC;ENST00000378325:WtoC;ENST0
ENST00000313519:ItoV;ENST00000354919:ItoV;ENST00000378325:ItoV;ENST0000
ENST00000313519:ItoK;ENST00000354919:ItoK;ENST00000378325:ItoK;ENST00000

131

+
+

+
+
+
+
+
+
+
+
+

+
+
+

+
+
+
+

+
+

+
+
+

TtoG
TtoG
TtoA
TtoC
AtoC
GtoT
AtoC
TtoG
GtoT
CtoA
GtoC
AtoG
AtoG
TtoA
GtoT
CtoT
TtoA
AtoG
CtoA
TtoG
AtoG
AtoG
TtoC
AtoC
TtoA
AtoG
TtoG
TtoC
CtoT
AtoG
AtoG
GtoC
TtoG
AtoG
TtoC
GtoA
AtoG
TtoC
AtoG
CtoA
CtoA
TtoC
TtoC
TtoC
TtoC
TtoC
TtoC
AtoG
TtoA
AtoG
TtoA
TtoG
TtoG
AtoC
TtoC
TtoC
AtoG
TtoC
TtoA
TtoA
TtoC
AtoG
AtoG
AtoG
AtoG
CtoA
TtoA
GtoA
AtoG
GtoT
AtoG
AtoG
TtoC
CtoA
TtoG
GtoT
GtoT
TtoC
TtoA
AtoG
TtoC
AtoG
AtoG
AtoG
TtoC
GtoT
AtoG
TtoA
AtoT
TtoC
TtoC
CtoA
TtoG
TtoA
CtoA
TtoG

0.1
0.1053
0.1
0.1
0.1
0.125
0.1053
0.1
0.1282
0.1111
0.1
0.1053
0.1
0.125
0.1053
0.1667
0.1333
0.1304
0.1
0.1
0.1
0.1
0.1
0.12
0.1
0.1
0.2222
0.1143
0.1
0.1
0.1111
0.1
0.1333
0.1053
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1
0.1081
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.125
0.1
0.1667
0.1111
0.1
0.1111
0.1111
0.1
0.1053
0.1
0.1
0.1
0.1
0.1034
0.1538
0.1111
0.1316
0.1053
0.1
0.1176
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1154
0.1071
0.1111
0.1
0.1
0.1
0.1
0.1364
0.1
0.1
0.1
0.1
0.1042
0.1667
0.1

0.1
0.2222
0.1
0.1333
0.2
0.125
0.1053
0.15
0.2692
0.3182
0.3043
0.1333
0.1333
0.1818
0.1818
0.2609
0.1818
0.2
0.1
0.1
0.1538
0.1429
0.1538
0.2
0.6
0.125
0.4167
0.125
0.1
0.1
0.1579
0.1538
0.2
0.1143
0.1429
0.1111
0.2
0.1818
0.1176
0.1
0.1053
0.1053
0.1304
0.1538
0.1
0.1481
0.1333
0.2
0.1818
0.1333
0.2
0.1818
0.1
0.25
0.25
0.125
0.1818
0.1111
0.1
0.125
0.15
0.1538
0.1111
0.1538
0.303
0.1333
0.1818
0.1739
0.5
0.129
0.1429
0.1333
0.1818
0.125
0.1034
0.2105
0.1
0.1765
0.1176
0.1
0.1333
0.1333
0.1667
0.1818
0.2
0.1
0.5
0.2
0.2105
0.1818
0.1
0.1333
0.1
0.1231
0.2727
0.1818

3
2
4
3
4
2
3
2
5
12
9
7
3
7
3
3
9
10
2
3
4
9
4
4
5
4
2
4
3
3
7
5
3
10
8
4
7
10
2
3
2
2
4
3
7
3
4
3
2
2
6
11
2
5
4
2
6
9
2
2
6
7
2
4
12
6
5
5
6
5
7
4
5
3
4
5
3
3
5
4
7
5
8
13
3
2
7
4
8
4
2
2
8
8
8
4

2
2
2
2
2
2
2
2
3
7
5
2
2
2
3
3
3
2
2
2
3
3
2
3
5
2
2
2
2
2
4
2
2
2
2
2
5
2
2
2
2
2
2
2
2
2
2
2
2
2
2
6
2
3
2
2
2
3
2
2
3
2
2
2
10
2
2
3
5
2
3
2
3
2
2
4
2
2
2
2
3
2
4
3
2
2
6
3
3
2
2
2
3
4
2
2

[10,10]
[10,19]
[10,10]
[10,15]
[10,10]
[16,32]
[19,19]
[20,20]
[16,39]
[11,22]
[10,23]
[15,21]
[10,15]
[11,17]
[11,19]
[12,23]
[11,16]
[24,26]
[10,10]
[10,20]
[10,17]
[14,20]
[10,13]
[10,25]
[10,22]
[10,16]
[10,12]
[16,38]
[10,10]
[10,10]
[13,19]
[10,13]
[10,15]
[19,35]
[16,22]
[10,18]
[10,30]
[10,11]
[10,17]
[10,10]
[10,19]
[19,20]
[10,23]
[13,16]
[20,20]
[27,37]
[10,15]
[10,11]
[10,11]
[10,15]
[10,11]
[11,26]
[10,10]
[20,22]
[12,16]
[10,16]
[11,12]
[18,28]
[10,10]
[16,19]
[27,61]
[10,13]
[18,19]
[10,13]
[16,43]
[10,15]
[10,12]
[18,58]
[11,14]
[10,33]
[14,38]
[16,19]
[10,24]
[17,24]
[21,30]
[17,20]
[10,10]
[10,17]
[17,30]
[10,10]
[10,15]
[15,26]
[24,92]
[18,33]
[10,10]
[10,10]
[10,13]
[10,16]
[17,22]
[10,11]
[10,10]
[10,15]
[10,10]
[19,66]
[11,12]
[10,11]

TableS10

chr11:9729479
chr11:9729846
chr1:25422288
chr9:92699607
chr9:92700130
chr6:86377191
chr14:63666304
chr14:63762251
chr17:73680400
chr5:150018957
chr7:105519476
chr1:154121060
chr1:27549519
chr8:38815167
chr8:38824796
chr8:38826592
chr8:38829600
chr4:1716608
chr1:165098091
chr17:32911177
chr17:32911266
chr3:9796668
chr3:9796669
chr3:9796675
chr11:6588677
chr16:82771451
chr8:120864878
chr8:120864879
chr10:8046647
chr10:8047059
chr20:59984698
chr20:59984604
chr18:22223928
chr10:105138803
chr1:227816747
chr1:227816795
chr1:227805007
chr1:227805040
chr1:227805277
chr1:227816831
chr1:227804989
chr1:227805147
chr1:227805051
chr1:227805133
chr1:227812541
chr1:227804649
chr1:227804703
chr1:227805132
chr1:227805249
chr1:227812477
chr1:227812525
chr1:227816775
chr1:227816826
chr11:62302917
chr5:140678801
chr6:42144294
chr6:42154560
chr2:161769448
chr6:32904359
chr6:32904464
chr6:33375451
chr6:33375454
chr6:33375456
chr6:33375458
chr6:33377372
chr12:6438360
chr12:6440363
chr1:232635855
chr1:232609044
chr1:232652888
chr12:52186392
chr5:33490881
chr5:33503844
chr8:125570061
chr3:10295145
chr3:10297280
chr3:10297809
chr1:211055212
chr7:27834942
chr4:37699642
chr4:37696428
chr19:55082637
chr19:55073638
chr19:55077221
chr20:365065
chr22:45949498
chr22:45949579
chr3:17391143
chr3:17173779
chr3:17174068
chr3:17174552
chr3:17176481
chr2:101001892
chr2:100989214
chr2:100989313
chr2:100989314

SWAP70
SWAP70
SYF2
SYK
SYK
SYNCRIP
SYNE2
SYNE2
SYNGR2
SYNPO
SYPL1
SYT11
SYTL1
TACC1
TACC1
TACC1
TACC1
TACC3
TADA1L
TADA2L
TADA2L
TADA3L
TADA3L
TADA3L
TAF10
TAF1C
TAF2
TAF2
TAF3
TAF3
TAF4
TAF4
TAF4B
TAF5
TAF5L
TAF5L
TAF5L
TAF5L
TAF5L
TAF5L
TAF5L
TAF5L
TAF5L
TAF5L
TAF5L
TAF5L
TAF5L
TAF5L
TAF5L
TAF5L
TAF5L
TAF5L
TAF5L
TAF6L
TAF7
TAF8
TAF8
TANK
TAP2
TAP2
TAPBP
TAPBP
TAPBP
TAPBP
TAPBP
TAPBPL
TAPBPL
TARBP1
TARBP1
TARBP1
TARBP2
TARS
TARS
TATDN1
TATDN2
TATDN2
TATDN2
TATDN3
TAX1BP1
TBC1D1
TBC1D1
TBC1D17
TBC1D17
TBC1D17
TBC1D20
TBC1D22A
TBC1D22A
TBC1D5
TBC1D5
TBC1D5
TBC1D5
TBC1D5
TBC1D8
TBC1D8
TBC1D8
TBC1D8

UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
mixed
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
mixed
coding_exon
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
mixed

ENST00000318074:VtoM;ENST00000485269:VtoM;

ENST00000225396:Eto*;ENST00000394395:Eto*;

ENST00000341690:FtoV;ENST00000378541:FtoV;
ENST00000378164:LtoR;
ENST00000378164:LtoI;
ENST00000344293:StoA;
ENST00000344293:KtoR;
ENST00000252996:LtoP;
ENST00000269142:RtoQ;ENST00000418698:RtoQ;
ENST00000258281:StoP;ENST00000366674:StoP;ENST00000366675:StoP;ENST000
ENST00000258281:RtoW;ENST00000366674:RtoW;ENST00000366675:RtoW;ENST0
ENST00000258281:RtoH;ENST00000366675:RtoH;ENST00000366676:RtoH;
ENST00000258281:RtoH;ENST00000366675:RtoH;ENST00000366676:RtoH;
ENST00000258281:QtoP;ENST00000366675:QtoP;ENST00000366676:QtoP;
ENST00000258281:QtoE;ENST00000366674:QtoE;ENST00000366675:QtoE;ENST00
ENST00000258281:NtoS;ENST00000366675:NtoS;ENST00000366676:NtoS;
ENST00000258281:NtoK;ENST00000366675:NtoK;ENST00000366676:NtoK;
ENST00000258281:KtoN;ENST00000366675:KtoN;ENST00000366676:KtoN;
ENST00000258281:DtoG;ENST00000366675:DtoG;ENST00000366676:DtoG;
ENST00000258281:AtoV;ENST00000366675:AtoV;ENST00000366676:AtoV;

ENST00000294168:VtoG;
ENST00000372977:TtoA;ENST00000372982:TtoA;ENST00000456846:TtoA;ENST000
ENST00000259075:CtoW;ENST00000392749:CtoW;ENST00000402568:CtoW;ENST0

ENST00000266556:QtoR;
ENST00000266556:QtoP;
ENST00000040877:GtoD;

ENST00000276692:NtoK;
ENST00000287652:QtoR;ENST00000448281:QtoR;

ENST00000265393:HtoR;ENST00000396319:HtoR;ENST00000409980:HtoR;ENST00
ENST00000261439:VtoG;
ENST00000261439:KtoR;
ENST00000221543:WtoG;
ENST00000221543:KtoN;

ENST00000253692:YtoS;ENST00000429383:YtoS;ENST00000429924:YtoS;ENST0000

132

+
+

+
+

+
+
+
+

+
+
+
+
+
+
+

+
+

+
+

+
+

+
+
+

+
+

+
+
+

+
+
+
+
+
+
+
+
+
+

+
+

GtoA
AtoG
AtoG
TtoG
TtoC
TtoA
AtoG
TtoC
TtoA
TtoC
AtoG
TtoC
GtoA
CtoA
GtoA
TtoA
TtoC
AtoG
TtoC
GtoT
TtoC
TtoG
CtoA
TtoA
TtoC
TtoG
TtoG
CtoA
TtoG
AtoG
TtoC
TtoC
GtoA
AtoG
TtoC
CtoT
GtoA
GtoA
AtoC
CtoG
AtoG
TtoA
GtoT
AtoG
CtoT
TtoC
CtoT
TtoC
CtoT
TtoC
AtoG
TtoC
TtoC
TtoG
AtoG
AtoG
AtoG
TtoG
AtoG
TtoC
AtoG
TtoC
CtoA
TtoA
CtoT
AtoG
AtoC
GtoA
AtoG
TtoG
TtoC
TtoC
TtoC
TtoA
AtoG
GtoA
TtoA
AtoG
AtoG
TtoG
AtoG
TtoG
GtoT
AtoG
TtoC
CtoA
TtoC
AtoC
TtoA
GtoC
AtoC
AtoG
AtoC
AtoT
GtoT
AtoT

0.1053
0.1
0.1
0.1
0.72
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1724
0.1
0.1
0.1818
0.1
0.1
0.1
0.1
0.1
0.102
0.1667
0.12
0.1429
0.25
0.1818
0.1
0.1
0.1
0.1111
0.125
0.1111
0.1
0.25
0.1
0.2
0.1667
0.1364
0.2
0.1
0.2
0.1176
0.1
0.2
0.1
0.1429
0.1364
0.1176
0.1429
0.1111
0.1
0.1053
0.1111
0.1034
0.1
0.1765
0.1
0.1
0.1026
0.1017
0.1
0.1176
0.1
0.1053
0.1
0.1
0.1
0.1053
0.125
0.1
0.1176
0.1
0.1
0.1
0.1
0.1111
0.1
0.1333
0.1
0.1538
0.1
0.1118
0.3671

0.1333
0.1176
0.1333
0.1765
0.8421
0.1429
0.1818
0.1053
0.1
0.1818
0.1176
0.1
0.1
0.125
0.1667
0.1538
0.1818
0.1667
0.1818
0.1
0.1
0.1111
0.1
0.1667
0.2222
0.2222
0.1875
0.2
0.1
0.1333
0.1818
0.1
0.1818
0.1538
0.9167
1
0.5
0.8235
0.2308
0.1333
0.3125
0.3077
0.875
0.3636
0.3
0.25
0.8
0.4615
0.4545
0.4
0.95
0.9667
0.4
0.2
0.125
0.1
0.2941
0.1818
0.2222
0.2
0.3529
0.2
0.1429
0.2222
0.2
0.1667
0.2308
0.1
0.2
0.1
0.2667
0.1111
0.1154
0.1111
0.1818
0.1
0.1429
0.1
0.2632
0.1
0.1875
0.1538
0.1333
0.1786
0.125
0.1
0.1
0.1
0.1765
0.1481
0.15
0.1
0.1818
0.2308
0.5185
0.8333

2
8
5
6
3
3
3
2
2
3
4
3
2
2
10
7
6
4
3
2
6
4
2
5
4
6
5
4
2
2
3
2
2
17
4
10
8
9
4
7
5
6
9
5
8
3
8
4
7
5
13
12
4
4
3
2
3
6
4
4
3
5
5
6
6
2
8
3
2
4
6
2
11
3
2
2
7
2
15
2
2
4
5
4
3
2
2
3
15
4
3
3
3
3
15
10

2
3
2
3
2
2
2
2
2
3
2
2
2
2
3
3
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
4
4
9
7
6
3
2
3
5
8
3
5
2
6
3
4
2
9
12
3
2
2
2
2
3
2
3
3
2
3
6
3
2
6
2
2
2
3
2
3
2
2
2
2
2
10
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
15
10

[15,19]
[10,17]
[15,20]
[10,17]
[19,25]
[10,14]
[10,11]
[10,19]
[10,10]
[10,12]
[10,17]
[10,10]
[10,20]
[16,18]
[12,30]
[13,20]
[10,11]
[12,20]
[10,11]
[10,10]
[10,10]
[10,10]
[10,10]
[12,18]
[10,32]
[10,12]
[10,16]
[11,15]
[10,10]
[10,15]
[10,11]
[10,10]
[10,11]
[49,115]
[11,15]
[17,41]
[10,23]
[16,24]
[10,13]
[10,15]
[10,16]
[10,20]
[12,21]
[11,16]
[11,23]
[10,12]
[10,12]
[10,17]
[10,14]
[10,12]
[10,25]
[10,30]
[13,20]
[10,10]
[17,32]
[10,10]
[10,17]
[10,20]
[10,14]
[10,22]
[10,18]
[15,22]
[14,32]
[12,31]
[10,19]
[10,12]
[13,31]
[10,10]
[10,17]
[10,10]
[10,19]
[18,40]
[26,118]
[10,27]
[11,17]
[10,10]
[19,21]
[10,10]
[17,31]
[10,10]
[16,19]
[13,16]
[10,15]
[17,28]
[10,16]
[10,10]
[10,10]
[10,10]
[18,37]
[20,27]
[15,20]
[10,10]
[11,13]
[10,14]
[27,471]
[13,170]

TableS10

chr2:100989315
chr2:100989317
chr5:179222356
chr5:77022881
chr1:233644522
chr12:63177068
chr7:72626777
chr7:72622801
chr6:134350162
chr8:55054254
chr8:55063271
chr20:62168771
chr20:62165690
chr20:62168274
chr20:62168276
chr8:75021435
chr8:75021440
chr16:2761989
chr1:23950016
chr1:23958813
chr5:145863275
chr5:145839650
chr15:55367486
chr22:40940121
chr22:40940737
chr18:51045271
chr18:51045932
chr18:51045966
chr5:133502627
chr5:133502625
chr5:133505777
chr5:133505776
chr5:133511214
chr12:108830883
chr12:108826930
chr11:67567074
chr11:67574934
chr11:33063141
chr11:33062920
chr11:33063140
chr14:89503492
chr9:99233120
chr9:99262707
chr4:47835790
chr7:97683578
chr16:1485608
chr14:19904217
chr14:19904223
chr14:19904333
chr14:19904355
chr14:19904356
chr14:19904361
chr14:19904897
chr14:19904900
chr14:19904936
chr14:19904940
chr14:19904954
chr14:19904979
chr14:19906382
chr16:67958431
chr16:67976039
chr16:67952893
chr1:45582824
chr4:106416808
chr4:106419942
chr2:74186008
chr2:74186728
chr2:74187616
chr2:74187761
chr2:74188482
chr2:74188494
chr9:102151371
chr9:102104278
chr17:59579446
chr15:54508385
chr10:59815388
chr12:49775054
chr3:143153121
chr6:41759705
chr3:101950110
chr19:46528658
chr1:91921247
chr2:105263286
chr2:105248849
chr2:105250011
chr20:34652727
chr20:34652798
chr20:34654000
chr20:34655683
chr2:85400243
chr2:85401235
chr2:85401584
chr2:85403272
chr2:85403333
chr8:56900347
chr20:57002211

TBC1D8
TBC1D8
TBC1D9B
TBCA
TBCE
TBK1
TBL2
TBL2
TBPL1
TCEA1P2
TCEA1P2
TCEA2
TCEA2
TCEA2
TCEA2
TCEB1
TCEB1
TCEB2
TCEB3
TCEB3
TCERG1
TCERG1
TCF12
TCF20
TCF20
TCF4
TCF4
TCF4
TCF7
TCF7
TCF7
TCF7
TCF7
TCHP
TCHP
TCIRG1
TCIRG1
TCP11L1
TCP11L1
TCP11L1
TDP1
TDRD7
TDRD7
TEC
TECPR1
TELO2
TEP1
TEP1
TEP1
TEP1
TEP1
TEP1
TEP1
TEP1
TEP1
TEP1
TEP1
TEP1
TEP1
TERF2
TERF2
TERF2
TESK2
TET2
TET2
TET3
TET3
TET3
TET3
TET3
TET3
TEX10
TEX10
TEX2
TEX9
TFAM
TFCP2
TFDP2
TFEB
TFG
TGFB1
TGFBR3
TGFBRAP1
TGFBRAP1
TGFBRAP1
TGIF2
TGIF2
TGIF2
TGIF2
TGOLN2
TGOLN2
TGOLN2
TGOLN2
TGOLN2
TGS1
TH1L

mixed
mixed
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
coding_exon
coding_exon
mixed
coding_exon
UTR3
coding_exon
coding_exon
UTR3
mixed
mixed
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
coding_exon
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon

ENST00000366601:TtoP;ENST00000406207:TtoP;
ENST00000305632:QtoK;ENST00000432538:QtoK;ENST00000452475:QtoK;
ENST00000305632:LtoR;ENST00000432538:LtoR;
ENST00000396401:RtoW;ENST00000399633:RtoW;
ENST00000396401:RtoQ;ENST00000399633:RtoQ;

ENST00000284811:NtoS;

ENST00000374536:YtoN;ENST00000418390:YtoN;
ENST00000296702:YtoH;ENST00000394421:YtoH;
ENST00000296702:QtoR;ENST00000394421:QtoR;

ENST00000321584:WtoR;ENST00000321603:WtoR;ENST00000340914:WtoR;ENST0
ENST00000321584:StoT;ENST00000321603:StoT;ENST00000340914:StoT;ENST0000
ENST00000321584:FtoS;ENST00000321603:FtoS;ENST00000340914:FtoS;ENST0000
ENST00000321584:FtoL;ENST00000321603:FtoL;ENST00000340914:FtoL;ENST0000
ENST00000312777:LtoP;ENST00000405876:LtoP;
ENST00000265686:NtoS;
ENST00000324357:LtoF;

ENST00000254942:RtoG;
ENST00000254942:EtoA;

ENST00000373895:CtoW;ENST00000487519:CtoW;

ENST00000258449:LtoQ;ENST00000393359:LtoQ;

ENST00000373872:ItoV;ENST00000373874:ItoV;

133

+
+

+
+
+
+

+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+

+
+

+
+
+
+

+
+

AtoT
TtoC
AtoG
TtoC
AtoC
AtoG
CtoA
TtoG
AtoG
CtoT
GtoA
CtoA
GtoA
AtoT
GtoA
AtoG
TtoC
AtoC
TtoA
AtoC
TtoC
AtoG
AtoG
TtoC
CtoT
TtoC
CtoG
AtoG
TtoA
GtoC
TtoC
TtoC
TtoC
TtoC
TtoC
AtoG
TtoC
CtoT
AtoC
TtoC
TtoC
GtoC
GtoA
TtoC
TtoG
TtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoG
AtoC
AtoG
AtoG
TtoC
AtoG
TtoC
CtoT
AtoG
AtoG
AtoG
AtoG
CtoT
TtoC
GtoA
AtoG
TtoG
TtoC
TtoC
CtoG
TtoC
CtoA
TtoC
TtoA
AtoC
TtoC
AtoG
TtoA
CtoA
AtoG
TtoC
AtoT
CtoA
TtoC
AtoG
TtoG
TtoG

0.1304
0.2105
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.129
0.1176
0.1
0.125
0.1176
0.1
0.1
0.1143
0.1
0.1
0.1176
0.1
0.1111
0.1
0.1
0.1
0.1667
0.1
0.1071
0.1
0.1111
0.1053
0.1
0.125
0.1
0.1
0.1765
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1515
0.1
0.1176
0.1
0.1304
0.1333
0.1818
0.1
0.1
0.1667
0.4615
0.1
0.1
0.1
0.1667
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1818
0.1
0.1
0.1
0.2
0.1273
0.4
0.1538
0.1429
0.1
0.1
0.1111
0.1538
0.1667
0.1053
0.1111
0.1
0.1667
0.1667
0.1
0.1
0.1154

0.5882
0.25
0.1176
0.1538
0.1
0.1
0.1
0.125
0.1667
0.2097
0.2407
0.1
0.25
0.3333
0.2
0.1667
0.1778
0.925
0.1176
0.1429
0.1111
0.2
0.1818
0.1
0.4286
0.1818
0.1667
0.1111
0.2059
0.1667
0.119
0.2121
0.1429
0.1429
0.1
0.3636
0.3333
0.1667
0.1
0.1818
0.1
0.1
0.1429
0.2
0.1765
0.1538
0.1429
0.2
0.2727
0.3
0.25
0.1538
0.3
0.6154
0.2
0.1818
0.1
0.3846
0.3
0.1
0.12
0.1333
0.1
0.12
0.1818
0.1
0.1818
0.1818
0.1333
0.1429
0.1
0.1
0.1111
0.2
0.3
0.1304
0.1538
0.1111
0.2174
0.2222
0.5714
0.1538
0.1538
0.1
0.1429
0.1875
0.2143
0.1667
0.1053
0.1176
0.1
0.2727
0.1875
0.1111
0.2
0.1579

11
6
2
5
2
4
3
4
3
5
4
2
3
8
7
7
12
9
2
4
4
5
3
2
3
3
3
4
9
8
8
12
5
8
2
6
7
2
2
2
3
2
2
3
2
3
3
2
2
5
7
3
2
2
2
2
2
4
2
2
3
3
2
2
9
2
2
4
2
3
2
3
3
3
2
3
11
2
2
4
3
3
3
2
2
3
7
5
9
7
2
3
5
4
2
2

11
3
2
2
2
2
2
2
2
3
4
2
2
6
4
2
4
5
2
2
2
3
2
2
2
2
3
2
6
2
2
9
2
2
2
4
5
2
2
2
2
2
2
3
2
2
2
2
2
3
5
2
2
2
2
2
2
4
2
2
2
2
2
2
2
2
2
3
2
2
2
2
3
2
2
2
4
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2

[13,64]
[10,21]
[10,18]
[10,13]
[10,10]
[10,10]
[10,10]
[10,16]
[13,18]
[31,83]
[57,108]
[10,10]
[12,16]
[12,22]
[10,20]
[10,12]
[35,54]
[23,161]
[10,17]
[15,17]
[10,20]
[10,26]
[10,11]
[10,10]
[10,21]
[11,19]
[10,15]
[18,29]
[29,110]
[12,54]
[42,135]
[13,116]
[16,29]
[10,14]
[10,10]
[11,34]
[10,36]
[10,12]
[10,10]
[10,11]
[10,10]
[10,10]
[10,14]
[15,33]
[10,17]
[13,17]
[10,14]
[20,23]
[12,15]
[10,11]
[10,14]
[10,13]
[10,12]
[13,13]
[10,10]
[10,11]
[10,10]
[10,13]
[10,10]
[10,10]
[20,25]
[15,20]
[10,10]
[10,25]
[11,11]
[10,10]
[10,11]
[10,19]
[15,20]
[10,14]
[10,10]
[10,10]
[10,18]
[10,10]
[10,11]
[23,40]
[10,27]
[10,18]
[10,24]
[18,55]
[10,17]
[13,13]
[13,14]
[10,10]
[10,14]
[16,27]
[13,14]
[12,12]
[19,19]
[17,28]
[10,20]
[11,12]
[16,19]
[10,18]
[10,10]
[19,26]

TableS10

chr20:57003340
chr2:43565935
chr2:43657845
chr8:42812440
chr5:157100121
chr18:205461
chr18:214941
chr17:77439215
chr22:28280818
chr22:28276747
chr3:63794745
chr3:63794746
chr14:23095991
chr11:133623444
chr2:70296010
chr10:121324599
chr10:121325088
chr10:121346278
chr10:121346302
chr19:4768255
chr4:113417379
chr16:3281438
chr12:55113684
chr12:55110172
chr1:200205474
chr1:200205848
chr19:7912052
chr19:44672403
chr11:111461089
chr14:57945251
chr5:74108390
chr3:157906651
chr3:157906784
chr3:157907057
chr1:166437840
chr9:71059014
chr9:71021127
chr9:71059585
chr9:71059704
chr15:68140022
chr15:68128220
chr15:68128959
chr9:81526478
chr2:171625911
chr2:171556881
chr4:38451585
chr4:38451644
chr4:38452205
chr8:38967612
chr15:100000036
chr15:100000134
chr15:99999696
chr14:23728490
chr14:23728668
chr13:98986947
chr10:98277818
chr10:98326517
chr10:98271524
chr20:30217134
chr12:64818213
chr12:64825959
chr12:48444753
chr12:48444943
chr17:73634582
chr17:73648510
chr12:93486056
chr12:93486843
chr12:93487576
chr12:93487629
chr1:163963330
chr1:163963423
chr1:163963586
chr13:113250638
chr1:19881598
chr19:10806612
chr12:122648347
chr12:122648616
chr15:77402236
chr7:44585147
chr1:93390075
chr5:114978496
chr5:176955703
chr17:39444108
chr17:39444746
chr17:7279915
chr17:7279683
chr12:46648732
chr11:60446230
chr3:52864466
chr7:75454245
chr11:101774764
chr11:85039029
chr11:85045182
chr11:85022907
chr11:85017308
chr2:96284382

TH1L
THADA
THADA
THAP1
THG1L
THOC1
THOC1
THOC4
THOC5
THOC5
THOC7
THOC7
THTPA
THYN1
TIA1
TIAL1
TIAL1
TIAL1
TIAL1
TICAM1
TIFA
TIGD7
TIMELESS
TIMELESS
TIMM17A
TIMM17A
TIMM44
TIMM50
TIMM8B
TIMM9
TINP1
TIPARP
TIPARP
TIPARP
TIPRL
TJP2
TJP2
TJP2
TJP2
TLE3
TLE3
TLE3
TLE4
TLK1
TLK1
TLR10
TLR10
TLR10
TM2D2
TM2D3
TM2D3
TM2D3
TM9SF1
TM9SF1
TM9SF2
TM9SF3
TM9SF3
TM9SF3
TM9SF4
TMBIM4
TMBIM4
TMBIM6
TMBIM6
TMC6
TMC8
TMCC3
TMCC3
TMCC3
TMCC3
TMCO1
TMCO1
TMCO1
TMCO3
TMCO4
TMED1
TMED2
TMED2
TMED3
TMED4
TMED5
TMED7
TMED9
TMEM101
TMEM101
TMEM102
TMEM102
TMEM106C
TMEM109
TMEM110
TMEM120A
TMEM123
TMEM126A
TMEM126A
TMEM126B
TMEM126B
TMEM127

UTR3
mixed
mixed
mixed
UTR3
coding_exon
coding_exon
UTR3
mixed
UTR5
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR5
UTR5
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
mixed
mixed
mixed
UTR3
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR5
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR5
UTR3
mixed
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
coding_exon

ENST00000261600:EtoG;

ENST00000288014:Wto*;ENST00000404535:Wto*;

ENST00000229201:QtoE;ENST00000447258:QtoE;ENST00000452204:QtoE;
ENST00000229201:LtoR;ENST00000452204:LtoR;

ENST00000270538:StoP;

ENST00000348208:StoR;ENST00000377245:StoR;
ENST00000265384:HtoR;ENST00000348208:HtoR;ENST00000377245:HtoR;ENST00

ENST00000265284:QtoR;ENST00000376534:QtoR;ENST00000376537:QtoR;ENST00
ENST00000360843:TtoK;ENST00000431350:TtoK;ENST00000434911:TtoK;ENST000

ENST00000261789:YtoH;
ENST00000376387:CtoW;ENST00000419976:CtoW;
ENST00000371142:VtoL;

ENST00000286424:FtoV;ENST00000358230:FtoV;

ENST00000434316:VtoA;
ENST00000214869:Kto*;

ENST00000323206:MtoV;ENST00000396568:MtoV;

ENST00000304511:EtoK;
ENST00000304511:Eto*;

ENST00000258439:StoP;ENST00000432959:StoP;ENST00000435268:StoP;

134

+
+

+
+
+
+
+
+
+
+
+

+
+

+
+
+

+
+
+
+

+
+
+
+

TtoC
TtoG
TtoC
AtoG
GtoT
AtoG
AtoG
AtoG
AtoG
TtoC
AtoG
TtoA
GtoA
TtoC
AtoG
AtoG
TtoC
TtoC
TtoC
TtoG
TtoC
TtoC
CtoG
TtoG
TtoC
GtoA
TtoC
CtoA
AtoG
TtoC
TtoA
TtoA
TtoC
TtoG
TtoC
TtoG
AtoG
TtoG
AtoG
GtoC
GtoC
TtoA
AtoG
CtoA
TtoC
TtoC
AtoG
TtoA
AtoG
AtoG
TtoG
TtoC
TtoC
TtoC
TtoG
GtoT
TtoC
TtoC
TtoA
TtoG
TtoA
AtoG
TtoA
AtoG
CtoG
TtoA
TtoC
CtoG
AtoT
TtoA
AtoG
TtoG
TtoC
CtoA
AtoT
CtoT
TtoC
TtoC
TtoA
TtoC
CtoA
TtoA
TtoC
TtoG
AtoG
TtoA
TtoA
AtoC
TtoC
AtoG
TtoA
GtoA
GtoT
TtoC
GtoT
TtoC

0.1207
0.1
0.1
0.1
0.1
0.1
0.1176
0.1538
0.1905
0.1
0.1429
0.1
0.1
0.1053
0.1852
0.1
0.12
0.1
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1333
0.1
0.1053
0.1111
0.1304
0.1538
0.1
0.1
0.1667
0.1
0.125
0.1
0.1
0.1
0.5
0.6087
0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1818
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1667
0.1111
0.125
0.1
0.125
0.1053
0.1
0.1
0.1
0.1
0.1
0.1154
0.1
0.1
0.1
0.1176
0.1176
0.1538
0.1026
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1034
0.1
0.1429
0.2273
0.1053
0.1
0.1
0.1
0.1071

0.125
0.1
0.125
0.1429
0.1
0.1053
0.2
0.2727
0.2
0.1176
0.3077
0.3333
0.1111
0.125
0.2727
0.1875
0.16
0.1333
0.1429
0.1176
0.1538
0.1
0.1538
0.1
0.1053
0.2727
0.1
0.1111
0.1333
0.2727
0.1538
0.1667
0.1
0.25
0.1
0.1923
0.1176
0.1
0.1
0.6818
1
0.1667
0.1
0.1053
0.1
0.1
0.1053
0.1
0.1176
0.2
0.1
0.1875
0.1111
0.1429
0.1429
0.1538
0.1333
0.1
0.1429
0.2
0.2
0.1667
0.125
0.1333
0.1429
0.1
0.1429
0.1
0.1
0.2
0.1176
0.25
0.1
0.1
0.1667
0.3
0.2727
0.1429
0.1333
0.1667
0.1
0.3
0.2
0.1818
0.1
0.1053
0.1333
0.1818
0.1
0.1875
0.2727
0.1667
0.1
0.1034
0.1905
0.1667

2
3
2
2
2
3
4
5
4
2
3
7
3
3
7
5
8
2
2
3
2
4
4
6
9
6
2
11
3
4
2
3
5
2
2
7
4
4
3
2
2
2
2
3
4
8
5
5
3
2
6
7
3
2
4
3
3
2
3
7
2
5
4
4
6
3
3
3
2
3
3
4
2
3
3
5
5
4
5
3
2
11
3
4
2
2
13
4
3
3
5
3
3
2
4
6

2
2
2
2
2
2
3
4
2
2
2
6
2
2
5
2
2
2
2
2
2
2
3
2
2
3
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
3
3
2
2
2
2
2
2
3
2
2
2
2
2
3
4
3
2
2
2
6
3
2
2
2
4
3
2
2
2
2
2
2
2
2

[16,58]
[10,10]
[10,16]
[10,14]
[10,10]
[10,19]
[10,17]
[11,29]
[10,23]
[10,17]
[14,21]
[10,25]
[10,18]
[19,24]
[11,27]
[16,20]
[25,25]
[10,15]
[14,16]
[10,17]
[10,13]
[10,10]
[10,19]
[10,20]
[20,20]
[11,15]
[10,10]
[20,27]
[10,15]
[11,23]
[14,14]
[10,24]
[10,20]
[12,12]
[10,10]
[26,32]
[17,20]
[10,10]
[10,10]
[20,22]
[18,23]
[12,13]
[10,10]
[10,19]
[10,30]
[10,11]
[19,42]
[10,10]
[10,17]
[11,11]
[10,11]
[11,34]
[10,18]
[10,14]
[21,27]
[10,13]
[10,16]
[10,10]
[10,14]
[10,20]
[10,18]
[12,16]
[10,17]
[16,17]
[21,58]
[10,10]
[10,14]
[10,10]
[10,10]
[10,13]
[17,26]
[16,30]
[10,10]
[10,20]
[12,17]
[10,20]
[10,27]
[14,39]
[10,15]
[12,19]
[10,10]
[10,14]
[10,11]
[11,11]
[10,10]
[10,19]
[15,53]
[11,34]
[10,10]
[15,16]
[23,24]
[12,19]
[10,10]
[10,29]
[10,21]
[18,28]

TableS10

chr2:96280671
TMEM127
chr2:97749012
TMEM131
chr2:97779138
TMEM131
chr2:97779280
TMEM131
chr2:97739987
TMEM131
chr11:60461131 TMEM132A
chr11:60461161 TMEM132A
chr11:60888545
TMEM138
chr6:10864792
TMEM14B
chr16:21089346
TMEM159
chr19:19093436 TMEM161A
chr7:112194256
TMEM168
chr11:62314375 TMEM179B
chr2:665530
TMEM18
chr1:201259253 TMEM183A
chr20:48180834
TMEM189
chr20:48174263 MEM189UBE2V
chr12:70376561
TMEM19
chr12:70381040
TMEM19
chr12:70383459
TMEM19
chr6:130804361 TMEM200A
chr6:130804437 TMEM200A
chr16:65820512
TMEM208
chr2:27118048
TMEM214
chr11:60922636
TMEM216
chr1:27534906
TMEM222
chr1:27535317
TMEM222
chr11:62314951
TMEM223
chr11:117920912
TMEM25
chr1:32313201
TMEM39B
chr1:32340633
TMEM39B
chr3:186692132
TMEM41A
chr3:186690313
TMEM41A
chr3:186690411
TMEM41A
chr3:186691945
TMEM41A
chr11:9258931
TMEM41B
chr3:14159333
TMEM43
chr3:195789996
TMEM44
chr1:54031515
TMEM48
chr1:54003881
TMEM48
chr1:54006015
TMEM48
chr1:25559867
TMEM50A
chr1:25559996
TMEM50A
chr14:19995967
TMEM55B
chr7:77261655
TMEM60
chr1:224101458
TMEM63A
chr1:224100917
TMEM63A
chr1:45931502
TMEM69
chr1:45932366
TMEM69
chr1:45929325
TMEM69
chr8:75056314
TMEM70
chr1:154529302
TMEM79
chr15:32309380
TMEM85
chr2:112563702
TMEM87B
chr2:112563713
TMEM87B
chr2:112590158
TMEM87B
chr1:199370968
TMEM9
chr19:46584162
TMEM91
chr17:23670508
TMEM97
chr17:36244500
TMEM99
chr9:99371094
TMOD1
chr12:97466038
TMPO
chr4:91978817
TMSL3
chr4:91978820
TMSL3
chr4:91978822
TMSL3
chr4:91978825
TMSL3
chr14:50776897
TMX1
chr11:57261663
TMX2
chr11:57263060
TMX2
chr11:57262014
TMX2
chr11:57264277
TMX2
chr11:57262429
TMX2
chr11:57263051
TMX2
chr11:57262732
TMX2
chr11:57263209
TMX2
chr11:57263268
TMX2
chr11:57263022
TMX2
chr11:57264200
TMX2
chr11:57264361
TMX2
chr11:57264495
TMX2
chr11:57264520
TMX2
chr11:57264525
TMX2
chr11:57264620
TMX2
chr11:57264655
TMX2
chr11:57264754
TMX2
chr11:57264813
TMX2
chr11:57264963
TMX2
chr11:57264993
TMX2
chr17:23696143
TNFAIP1
chr14:102662521
TNFAIP2
chr6:138245696
TNFAIP3
chr5:118757301
TNFAIP8
chr8:22941851
TNFRSF10B
chr8:22937706
TNFRSF10B
chr1:2479130
TNFRSF14
chr1:2481124
TNFRSF14

UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
mixed
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
mixed
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
coding_exon
UTR3
coding_exon
UTR3
UTR5
mixed
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
mixed
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR3
UTR3
coding_exon
coding_exon
mixed
mixed

ENST00000186436:StoG;ENST00000409062:StoG;ENST00000409721:StoG;ENST000
ENST00000186436:NtoD;ENST00000409062:NtoD;ENST00000409721:NtoD;ENST00

ENST00000278826:VtoA;ENST00000451389:VtoA;
ENST00000233047:StoP;ENST00000261388:StoP;ENST00000451578:StoP;
ENST00000162044:VtoG;ENST00000450333:VtoG;

ENST00000281017:ItoT;ENST00000355654:ItoT;ENST00000405941:ItoT;
ENST00000371650:TtoR;ENST00000371652:TtoR;ENST00000371656:TtoR;
ENST00000266673:StoL;ENST00000422859:StoL;
ENST00000266673:*toG;

ENST00000307366:LtoP;

ENST00000360494:VtoA;ENST00000371429:VtoA;

ENST00000366835:YtoC;
ENST00000372025:RtoG;

ENST00000283206:VtoG;
ENST00000283206:GtoR;

ENST00000259365:AtoD;ENST00000375175:AtoD;ENST00000395211:AtoD;

ENST00000457354:DtoG;
ENST00000278422:VtoA;ENST00000319399:VtoA;ENST00000378312:VtoA;
ENST00000278422:VtoA;ENST00000319399:VtoA;ENST00000378312:VtoA;
ENST00000278422:TtoA;ENST00000319399:TtoA;
ENST00000278422:NtoS;ENST00000319399:TtoA;ENST00000378312:NtoS;
ENST00000278422:LtoP;ENST00000319399:LtoP;ENST00000378312:LtoP;
ENST00000278422:KtoT;ENST00000319399:KtoT;ENST00000378312:KtoT;
ENST00000278422:KtoN;ENST00000319399:KtoN;ENST00000378312:KtoN;
ENST00000278422:KtoN;ENST00000319399:KtoN;ENST00000378312:KtoN;
ENST00000278422:ItoT;ENST00000319399:ItoT;ENST00000378312:ItoT;

ENST00000276431:VtoG;ENST00000347739:VtoG;
ENST00000276431:AtoS;ENST00000347739:AtoS;

135

+
+
+
+
+

+
+
+
+
+
+
+
+
+
+

+
+
+

+
+

+
+
+
+
+
+
+
+
+

+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+

AtoC
AtoG
AtoG
AtoG
CtoA
GtoT
AtoT
TtoC
CtoG
TtoC
TtoG
TtoG
GtoT
TtoC
TtoC
CtoG
TtoG
CtoT
TtoG
GtoC
TtoC
TtoC
TtoC
GtoA
AtoG
AtoG
AtoC
TtoC
TtoC
TtoC
AtoC
AtoG
TtoC
TtoC
CtoG
TtoA
AtoC
AtoG
TtoC
AtoG
TtoA
AtoG
AtoC
TtoG
TtoC
AtoG
AtoC
AtoG
CtoG
AtoG
TtoC
TtoA
AtoC
TtoG
GtoA
TtoA
TtoC
AtoG
AtoC
TtoA
CtoA
AtoG
CtoA
CtoG
GtoA
TtoC
AtoG
TtoC
TtoC
AtoG
AtoG
TtoC
AtoC
GtoC
GtoT
TtoC
AtoG
AtoG
GtoA
TtoG
TtoC
CtoT
GtoC
TtoC
CtoG
CtoT
AtoC
GtoA
TtoC
AtoG
GtoA
TtoC
TtoG
GtoT
GtoA
GtoT

0.1
0.1
0.1
0.1818
0.1111
0.1111
0.1154
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1538
0.1333
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1
0.1
0.1429
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.129
0.1
0.1
0.1
0.1
0.1
0.1
0.1538
0.1
0.1
0.125
0.3333
0.1
0.1
0.1
0.1034
0.1
0.1
0.1
0.1
0.1
0.1818
0.4
0.1053
0.1667
0.1034
0.1026
0.1311
0.1154
0.1111
0.1053
0.1067
0.1034
0.1
0.1
0.1017
0.12
0.1
0.12
0.1
0.1
0.1111
0.1
0.1087
0.1
0.1111
0.1429
0.1
0.1
0.1034
0.1111
0.1071
0.1
0.4545
0.1831

0.1
0.1818
0.1
0.1875
0.1333
0.4
0.1333
0.125
0.1667
0.125
0.1
0.1
0.1
0.1111
0.1176
0.1667
0.2
0.1
0.1
0.2667
0.2
0.125
0.1
0.1538
0.1
0.1
0.15
0.1818
0.1
0.15
0.1
0.1667
0.1333
0.1
0.1
0.2
0.1333
0.1053
0.1429
0.125
0.1
0.1579
0.1765
0.1111
0.1
0.1
0.1053
0.1053
0.4167
0.1111
0.1333
0.1333
0.36
0.1
0.1538
0.1
0.1053
0.1136
0.125
0.1111
0.1333
0.1429
0.4737
0.7
0.2381
0.2
0.3
0.1471
0.2373
0.2917
0.2222
0.1765
0.1373
0.4762
0.2308
0.1176
0.2826
0.25
0.1282
0.1379
0.2093
0.1458
0.1111
0.1786
0.2333
0.1579
0.2
0.1667
0.1
0.1
0.1136
0.1111
0.2778
0.1053
0.9
0.6957

3
4
4
2
5
4
11
2
7
2
3
2
2
6
5
2
5
2
2
2
2
2
6
3
3
2
4
3
3
2
4
2
3
2
5
3
2
2
3
4
2
11
2
3
2
2
2
2
3
2
4
4
2
2
2
2
5
3
2
3
3
5
6
7
7
2
2
10
10
17
16
7
9
14
13
5
12
12
12
8
10
14
9
6
11
8
12
5
5
3
6
5
4
2
2
13

2
2
2
2
2
4
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
6
7
4
2
2
4
6
16
9
2
5
12
10
2
10
8
2
2
8
4
2
4
6
3
9
2
4
2
2
2
2
2
2
13

[10,10]
[11,22]
[10,10]
[11,16]
[15,18]
[10,33]
[15,27]
[10,16]
[10,16]
[16,20]
[10,11]
[10,10]
[10,10]
[10,18]
[10,17]
[12,13]
[10,15]
[10,10]
[10,10]
[10,15]
[10,10]
[16,17]
[30,31]
[10,13]
[10,11]
[10,10]
[20,35]
[11,18]
[10,10]
[10,20]
[10,10]
[10,12]
[10,16]
[10,10]
[10,10]
[10,10]
[10,15]
[10,19]
[15,19]
[10,17]
[10,10]
[19,31]
[10,17]
[10,18]
[10,10]
[10,10]
[10,19]
[10,19]
[12,13]
[10,18]
[15,20]
[15,16]
[12,25]
[10,10]
[10,13]
[10,10]
[19,29]
[10,46]
[10,16]
[10,10]
[10,15]
[10,14]
[11,25]
[10,22]
[11,22]
[10,12]
[10,29]
[34,47]
[59,98]
[10,70]
[25,46]
[17,19]
[51,76]
[21,68]
[13,105]
[34,50]
[36,96]
[14,70]
[39,40]
[50,58]
[20,55]
[10,57]
[27,36]
[27,36]
[30,46]
[20,30]
[23,72]
[12,14]
[10,10]
[10,10]
[29,44]
[27,27]
[18,28]
[10,19]
[10,11]
[11,88]

TableS10

chr1:2481126
chr1:2481159
chr1:2481272
chr1:2481920
chr1:2482999
chr1:2483161
chr1:2484161
chr1:2484509
chr1:2484510
chr1:1129079
chr13:23141023
chr1:12189688
chr1:12087127
chr1:12120884
chr1:12126187
chr13:42079714
chr1:171421293
chr1:171421296
chr1:171421837
chr3:172377839
chr3:172263105
chr5:150389702
chr5:150424881
chr5:150446840
chr5:150446842
chr4:2713203
chr5:72224726
chr5:72236968
chr5:72245663
chr5:72245865
chr19:12692719
chr19:12671029
chr16:24708572
chr16:24709958
chr16:24710452
chr16:24739039
chr16:24742800
chr16:24743217
chr16:24743220
chr16:24744920
chr22:38988075
chr22:38991047
chr22:39051093
chr22:40161496
chr22:40161538
chr1:45580673
chr1:45581259
chr1:45581847
chr1:233352271
chr1:233352272
chr6:41865601
chr7:22819117
chr3:101566086
chr3:101566930
chr8:144462975
chr17:35799931
chr17:35818397
chr17:35798427
chr3:25632010
chr3:25636501
chr3:25653806
chr17:18124664
chr22:20643014
chr3:134819748
chr3:134829994
chr9:131620637
chr1:178144365
chr1:178101321
chr8:59913386
chr14:21037118
chr14:21037119
chr14:21037123
chr17:7512915
chr17:7512918
chr15:41500018
chr15:41511987
chr1:222034730
chr8:96008084
chr1:3642190
chr12:112214120
chr12:112190119
chr12:112220286
chr8:81112650
chr8:81112762
chr1:152411160
chr1:152411155
chr1:152411150
chr1:152412062
chr1:152412281
chr1:152412215
chr1:152412239
chr1:152412243
chr1:152422191
chr1:152422288
chr6:18257293
chr13:102099337

TNFRSF14
TNFRSF14
TNFRSF14
TNFRSF14
TNFRSF14
TNFRSF14
TNFRSF14
TNFRSF14
TNFRSF14
TNFRSF18
TNFRSF19
TNFRSF1B
TNFRSF8
TNFRSF8
TNFRSF8
TNFSF11
TNFSF4
TNFSF4
TNFSF4
TNIK
TNIK
TNIP1
TNIP1
TNIP1
TNIP1
TNIP2
TNPO1
TNPO1
TNPO1
TNPO1
TNPO2
TNPO2
TNRC6A
TNRC6A
TNRC6A
TNRC6A
TNRC6A
TNRC6A
TNRC6A
TNRC6A
TNRC6B
TNRC6B
TNRC6B
TOB2
TOB2
TOE1
TOE1
TOE1
TOMM20
TOMM20
TOMM6
TOMM7
TOMM70A
TOMM70A
TOP1MT
TOP2A
TOP2A
TOP2A
TOP2B
TOP2B
TOP2B
TOP3A
TOP3B
TOPBP1
TOPBP1
TOR1A
TOR1AIP1
TOR1AIP2
TOX
TOX4
TOX4
TOX4
TP53
TP53
TP53BP1
TP53BP1
TP53BP2
TP53INP1
TP73
TPCN1
TPCN1
TPCN1
TPD52
TPD52
TPM3
TPM3
TPM3
TPM3
TPM3
TPM3
TPM3
TPM3
TPM3
TPM3
TPMT
TPP2

mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
coding_exon
UTR3
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR5
UTR5
UTR5
UTR3
mixed
mixed
UTR3
UTR3
coding_exon
UTR3
mixed
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
coding_exon
UTR3
UTR3
UTR3
mixed
mixed
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
coding_exon
coding_exon

ENST00000263932:CtoS;

ENST00000284483:TtoP;ENST00000341852:TtoP;ENST00000357327:TtoP;ENST000

ENST00000356861:TtoP;ENST00000420511:TtoP;ENST00000425528:TtoP;ENST000

ENST00000301923:AtoS;ENST00000335727:AtoS;ENST00000400140:AtoS;ENST000

ENST00000372090:TtoP;
ENST00000372090:StoP;
ENST00000366607:LtoR;
ENST00000366607:LtoI;

ENST00000348049:TtoP;ENST00000357601:TtoP;ENST00000423485:TtoP;ENST000
ENST00000348049:CtoW;ENST00000357601:CtoW;ENST00000423485:CtoW;ENST0

ENST00000357179:PtoT;ENST00000398789:PtoT;ENST00000398793:PtoT;ENST000

ENST00000351698:VtoG;ENST00000427355:VtoG;ENST00000437532:VtoG;
ENST00000271583:StoP;ENST00000367610:StoP;ENST00000398836:StoP;

ENST00000335509:YtoS;ENST00000392569:YtoS;
ENST00000335509:ItoT;ENST00000392569:ItoT;ENST00000428632:ItoT;

ENST00000328159:NtoS;ENST00000330188:NtoS;ENST00000341372:NtoS;ENST000
ENST00000328159:KtoE;ENST00000330188:KtoE;ENST00000341372:KtoE;ENST000
ENST00000328159:Cto*;ENST00000330188:Cto*;ENST00000341372:Cto*;ENST000
ENST00000271850:VtoA;ENST00000302206:VtoA;ENST00000312970:VtoA;ENST00
ENST00000271850:NtoS;ENST00000302206:NtoS;ENST00000312970:NtoS;ENST000
ENST00000271850:ItoT;ENST00000302206:ItoT;ENST00000312970:ItoT;ENST00000
ENST00000271850:ItoS;ENST00000302206:ItoS;ENST00000312970:ItoS;ENST00000
ENST00000271850:EtoK;ENST00000302206:EtoK;ENST00000312970:EtoK;ENST000

ENST00000309983:DtoE;
ENST00000376052:LtoH;ENST00000376065:LtoH;

136

+
+
+
+
+
+
+
+
+

+
+
+
+
+
+

+
+
+
+

+
+
+
+
+
+
+
+
+
+
+

+
+
+

+
+
+

+
+
+
+

TtoC
CtoA
TtoC
GtoC
AtoG
AtoG
GtoC
AtoG
CtoG
TtoC
AtoG
TtoC
TtoA
TtoC
GtoC
GtoA
GtoC
AtoG
TtoG
AtoC
AtoT
TtoA
GtoC
AtoG
CtoT
TtoG
TtoG
GtoA
AtoC
AtoG
AtoC
TtoG
TtoC
TtoC
TtoC
TtoC
CtoG
AtoG
AtoG
AtoT
GtoT
TtoC
AtoG
CtoA
AtoG
AtoC
TtoC
CtoT
TtoG
CtoA
AtoG
TtoA
AtoC
TtoG
TtoG
AtoC
TtoG
TtoC
AtoG
AtoG
TtoC
TtoC
CtoA
GtoA
AtoG
TtoG
TtoC
AtoT
GtoA
GtoA
AtoT
TtoC
GtoA
TtoC
TtoC
AtoG
GtoT
AtoG
AtoG
AtoC
TtoC
TtoC
AtoG
TtoA
AtoG
AtoG
TtoA
TtoC
AtoG
TtoC
TtoG
GtoA
TtoG
TtoG
TtoA
TtoA

0.2857
0.1111
0.1
0.88
0.7647
0.102
1
0.1176
0.1111
1
0.1
0.1
0.1
0.4255
1
0.1
0.1111
0.125
0.1
0.1
0.1
0.25
0.1176
0.1127
0.1
0.1
0.1
0.1
0.1481
0.1
0.1667
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1333
0.1176
0.1111
0.1026
0.7778
0.1
0.1
0.1
0.1667
0.1053
0.1667
0.1111
0.1
0.1
0.1111
0.1
0.1
0.1
0.1081
0.1
0.1
0.1
0.1
0.1034
0.1
0.1081
0.1
0.1
0.1
0.1
0.1
0.1
0.15
0.1
0.1
0.1
0.1053
0.1071
0.1429
0.1
0.1
0.1071
0.1111
0.1
0.1071
0.1136
0.1
0.1
0.1053

0.75
0.2727
0.1
1
1
0.4
1
0.3333
0.7857
1
0.1
0.1
0.1
0.4583
1
0.2
0.1333
0.1579
0.1
0.1379
0.1
0.5556
0.2168
0.35
0.1818
0.1
0.1111
0.1
0.2143
0.1
0.3
0.1579
0.1818
0.125
0.1053
0.1
0.1111
0.1
0.1667
0.1
0.1053
0.1176
0.125
0.1
0.1
0.1
0.1818
0.1429
0.1579
0.1875
0.2143
1
0.1
0.1111
0.1
0.2143
0.1304
0.2
0.2
0.1333
0.1
0.1429
0.1
0.1667
0.1111
0.1176
0.1
0.1
0.1333
0.1351
0.1515
0.1538
0.1538
0.1346
0.1
0.1
0.1
0.1111
0.125
0.1667
0.1176
0.2
0.125
0.1538
0.1538
0.2
0.1
0.1389
0.1176
0.2308
0.3
0.1429
0.1698
0.1333
0.1
0.2

14
14
3
5
5
12
7
5
14
4
2
2
4
2
12
2
3
3
4
5
3
3
12
13
8
2
3
3
4
2
3
2
2
7
2
4
3
2
5
2
2
3
3
2
3
2
2
4
4
4
8
7
2
4
2
5
4
4
7
2
2
3
2
3
7
3
2
2
2
7
8
3
5
7
2
2
2
2
2
2
2
2
4
4
7
3
4
6
4
3
6
10
7
6
4
2

14
11
2
5
5
8
7
5
14
4
2
2
2
2
12
2
2
2
2
2
3
3
7
12
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
3
7
2
2
2
2
3
2
3
2
2
2
2
2
3
2
2
2
2
4
5
2
2
4
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
3
2
4
3
3
2
2

[13,84]
[11,62]
[10,10]
[10,25]
[11,38]
[11,75]
[13,25]
[10,37]
[11,63]
[10,52]
[10,10]
[10,10]
[10,21]
[24,47]
[20,114]
[10,10]
[15,18]
[16,19]
[10,10]
[10,29]
[10,10]
[17,22]
[13,143]
[11,124]
[10,22]
[10,10]
[10,19]
[10,10]
[14,27]
[10,10]
[10,12]
[10,19]
[10,11]
[10,24]
[10,20]
[10,10]
[10,18]
[10,10]
[10,12]
[10,10]
[19,20]
[17,18]
[10,16]
[10,10]
[10,10]
[10,10]
[10,11]
[14,15]
[17,19]
[16,18]
[10,39]
[10,22]
[10,10]
[18,20]
[10,11]
[14,18]
[19,51]
[11,12]
[10,36]
[15,20]
[10,10]
[21,27]
[10,10]
[10,12]
[10,19]
[34,37]
[10,10]
[10,10]
[10,15]
[27,50]
[28,46]
[10,13]
[13,37]
[16,52]
[10,10]
[10,20]
[10,10]
[10,27]
[10,16]
[12,20]
[10,17]
[10,10]
[10,16]
[13,19]
[13,28]
[10,15]
[10,10]
[20,37]
[17,28]
[13,18]
[10,10]
[14,28]
[55,98]
[15,41]
[10,10]
[10,19]

TableS10

chr13:102124646
chr13:102088664
chr1:184570123
chr1:184579723
chr2:73817938
chr2:73817939
chr22:25258688
chr22:25252230
chr13:44809009
chr13:44809310
chr13:44809311
chr7:23512284
chr7:23510965
chr3:187117952
chr14:22086302
chr14:22064519
chr14:22090527
chr14:22090531
chr14:22090659
chr14:22090663
chr14:22090937
chr9:122706067
chr9:122706090
chr9:122728248
chr9:122728838
chr9:122730531
chr6:111986886
chr1:208003344
chr1:209612973
chr1:209614039
chr16:2166941
chr16:2166945
chr3:42226478
chr2:201959283
chr2:201959354
chr8:71649744
chr8:71649751
chr8:71649690
chr8:71649695
chr21:44331164
chr21:44348551
chr21:44348578
chr21:44348825
chr1:36375039
chr19:7653738
chr19:50358031
chr19:50358032
chr8:141476920
chr8:141379822
chr6:41267629
chr6:42312059
chr3:48482845
chr8:126515030
chr8:126515031
chr8:126517907
chr8:126518926
chr20:324969
chr1:226648685
chr13:49485011
chr11:4362819
chr11:5687113
chr11:5688321
chr7:137920843
chr17:52328287
chr17:52321345
chr17:52321523
chr17:52322250
chr6:30262240
chr6:28978802
chr19:63751305
chr1:114771400
chr1:114741396
chr11:5620229
chr8:27207575
chr17:54464226
chr17:54493232
chr17:54473958
chr6:26092511
chr5:180594306
chr5:180583543
chr11:35785193
chr11:5642188
chr11:5642304
chr5:180615158
chr7:100518122
chr7:100519861
chr17:71400176
chr11:4577424
chr15:42835949
chr15:42838344
chr5:14454138
chr5:14440693
chr5:14562061
chr22:36495094
chr2:230366078
chr2:230378826

TPP2
TPP2
TPR
TPR
TPRKB
TPRKB
TPST2
TPST2
TPT1
TPT1
TPT1
TRA2A
TRA2A
TRA2B
TRAC
TRAC
TRAC
TRAC
TRAC
TRAC
TRAC
TRAF1
TRAF1
TRAF1
TRAF1
TRAF1
TRAF3IP2
TRAF3IP3
TRAF5
TRAF5
TRAF7
TRAF7
TRAK1
TRAK2
TRAK2
TRAM1
TRAM1
TRAM1
TRAM1
TRAPPC10
TRAPPC10
TRAPPC10
TRAPPC10
TRAPPC3
TRAPPC5
TRAPPC6A
TRAPPC6A
TRAPPC9
TRAPPC9
TREML2
TRERF1
TREX1
TRIB1
TRIB1
TRIB1
TRIB1
TRIB3
TRIM11
TRIM13
TRIM21
TRIM22
TRIM22
TRIM24
TRIM25
TRIM25
TRIM25
TRIM25
TRIM26
TRIM27
TRIM28
TRIM33
TRIM33
TRIM34
TRIM35
TRIM37
TRIM37
TRIM37
TRIM38
TRIM41
TRIM41
TRIM44
TRIM5
TRIM5
TRIM52
TRIM56
TRIM56
TRIM65
TRIM68
TRIM69
TRIM69
TRIO
TRIO
TRIO
TRIOBP
TRIP12
TRIP12

coding_exon
coding_exon
coding_exon
coding_exon
UTR5
UTR5
coding_exon
UTR3
mixed
mixed
mixed
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR5
UTR5
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR5
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon
UTR3
mixed
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR5
UTR3
mixed
mixed
UTR3
mixed
mixed
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon

ENST00000376052:KtoN;ENST00000376065:KtoN;

ENST00000297071:Yto*;

ENST00000442641:DtoA;ENST00000452868:DtoA;

ENST00000327628:StoT;ENST00000341421:StoT;ENST00000396175:StoT;

ENST00000262213:NtoD;

ENST00000291574:HtoD;

ENST00000317378:PtoR;ENST00000426877:PtoR;ENST00000452406:PtoR;

ENST00000301226:VtoD;ENST00000389327:VtoD;ENST00000389328:VtoD;ENST00
ENST00000301226:StoP;ENST00000389327:StoP;ENST00000389328:StoP;ENST000

ENST00000311922:EtoA;

ENST00000217233:StoP;ENST00000422053:StoP;
ENST00000298772:WtoR;ENST00000356017:WtoR;ENST00000420995:WtoR;
ENST00000379965:FtoI;ENST00000455293:FtoI;

ENST00000437089:TtoP;ENST00000453195:TtoP;ENST00000454678:TtoP;

ENST00000358465:DtoY;ENST00000369543:DtoY;ENST00000450349:DtoY;
ENST00000354852:LtoR;ENST00000380089:LtoR;ENST00000396866:LtoR;
ENST00000305364:LtoP;ENST00000380544:LtoP;
ENST00000262294:StoR;ENST00000376149:StoR;ENST00000393066:StoR;
ENST00000262294:RtoQ;ENST00000376149:RtoQ;ENST00000393066:RtoQ;
ENST00000262294:AtoG;ENST00000376149:AtoG;ENST00000393066:AtoG;

ENST00000269383:NtoD;
ENST00000329464:HtoP;ENST00000338264:HtoP;
ENST00000344204:RtoG;

ENST00000403663:LtoR;ENST00000406386:LtoR;

137

+
+

+
+
+
+
+
+
+

+
+
+
+
+
+

+
+
+
+

+
+
+
+
+
+

+
+
+

+
+
+
+

+
+

+
+
+
+
+
+

AtoT
AtoG
AtoG
TtoC
TtoA
AtoT
AtoC
TtoC
TtoC
TtoA
TtoA
CtoA
TtoC
TtoA
AtoC
TtoA
TtoG
CtoA
AtoG
CtoT
AtoG
TtoA
AtoG
CtoT
TtoC
TtoG
TtoC
TtoG
GtoA
AtoG
GtoA
TtoG
TtoA
TtoC
TtoC
AtoG
TtoC
AtoG
TtoC
CtoG
AtoG
TtoC
TtoA
TtoC
CtoG
AtoG
AtoG
TtoA
TtoC
TtoA
AtoG
TtoA
AtoC
GtoA
TtoC
TtoC
TtoC
TtoC
TtoC
GtoT
TtoA
TtoC
AtoG
TtoA
TtoG
TtoA
TtoC
AtoC
GtoA
TtoC
GtoT
TtoC
TtoG
TtoC
CtoA
GtoA
CtoG
TtoC
TtoG
TtoC
GtoA
TtoG
TtoC
TtoC
AtoG
AtoC
AtoG
TtoA
AtoC
AtoG
AtoG
GtoA
AtoG
TtoG
TtoG
TtoC

0.1111
0.125
0.1
0.1053
0.1111
0.1333
0.1
0.1111
0.1053
0.1268
0.1176
0.1087
0.1
0.1
0.1
0.3889
0.1
0.1625
0.1071
0.1053
0.1333
0.1136
0.1558
0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1765
0.1
0.1
0.1
0.1
0.1
0.1667
0.1364
0.1
0.1667
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1667
0.1111
0.1
0.9964
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1429
0.1
0.1
0.1
0.1
0.1
0.1
0.1154
0.1
0.1
0.1
0.1
0.2
0.1818
0.1
0.1071
0.1
0.125
0.1176

0.1304
0.1579
0.1333
0.1818
0.25
0.2222
0.1176
0.12
0.1923
0.1887
0.3857
0.125
0.1
0.1304
0.1
0.9
0.2609
0.4118
0.2
0.4211
0.6
0.119
0.2941
0.1379
0.1818
0.1
0.1333
0.1
0.1
0.1667
0.1364
0.2308
0.1
0.2
0.1
0.1667
0.1333
0.1667
0.2
0.1
0.1667
0.2
0.1111
0.1538
0.1818
0.125
0.2222
0.1
0.1429
0.1
0.1429
0.1667
0.2273
0.2759
0.1
0.1579
0.1111
0.1
0.2
0.1176
0.2
0.12
0.2308
0.1429
0.3571
0.1538
0.3
0.1818
0.1176
1
0.125
0.1364
0.1176
0.1429
0.1
0.1
0.1
0.1818
0.1429
0.1667
0.125
0.1379
0.1
0.1
0.1667
0.2727
0.2
0.1
0.1
0.2
0.1818
0.1
0.1818
0.1818
0.1429
0.125

7
5
4
7
7
7
2
5
13
10
16
9
7
6
2
2
5
9
3
7
4
4
11
4
3
3
5
3
2
6
10
2
4
3
2
8
5
3
4
3
8
5
5
8
5
4
7
2
3
2
3
2
5
3
2
5
2
2
6
3
8
5
6
8
4
4
8
3
5
13
2
3
3
3
2
2
2
2
2
2
5
5
2
2
2
2
2
2
2
5
4
2
5
2
2
4

2
2
2
3
7
7
2
3
6
4
6
2
2
2
2
2
4
8
2
7
4
2
10
2
2
2
4
2
2
3
4
2
2
2
2
3
3
2
2
2
2
3
2
2
3
2
3
2
2
2
2
2
2
2
2
3
2
2
3
2
3
2
3
3
3
2
3
2
2
13
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2

[23,27]
[16,19]
[10,15]
[11,26]
[11,21]
[11,25]
[10,17]
[17,25]
[13,39]
[55,149]
[52,160]
[47,56]
[10,10]
[20,23]
[11,20]
[10,18]
[14,23]
[17,80]
[20,28]
[19,39]
[10,25]
[42,46]
[17,77]
[17,29]
[10,11]
[10,10]
[10,16]
[20,20]
[10,10]
[10,26]
[10,30]
[14,17]
[20,20]
[10,10]
[10,10]
[10,20]
[15,20]
[12,12]
[10,22]
[10,10]
[12,24]
[10,15]
[18,20]
[26,30]
[10,16]
[10,17]
[10,22]
[10,10]
[14,16]
[10,10]
[10,14]
[10,12]
[10,22]
[10,29]
[10,10]
[10,19]
[10,10]
[10,10]
[10,16]
[10,17]
[26,40]
[10,25]
[10,14]
[18,21]
[10,14]
[10,13]
[11,12]
[11,18]
[10,17]
[12,457]
[10,16]
[20,22]
[10,18]
[14,18]
[10,10]
[10,10]
[10,10]
[11,14]
[10,14]
[10,12]
[10,18]
[11,29]
[10,10]
[10,10]
[12,26]
[10,11]
[10,10]
[10,10]
[10,10]
[10,10]
[11,11]
[10,10]
[11,28]
[10,11]
[14,16]
[16,17]

TableS10

chr5:970673
chr15:62503283
chr1:40082465
chr1:40082466
chr1:40079821
chr11:63841598
chr22:18482600
chr14:103071673
chr1:28763847
chr3:3145769
chr12:48004250
chr12:48009104
chr1:191327453
chr11:63747878
chr7:98440883
chr7:98385762
chr7:98419917
chr9:134766013
chr9:134757546
chr19:59389129
chr2:122239660
chr2:122241860
chr10:82268927
chr10:82270930
chr12:56425874
chr12:56426683
chr6:116705493
chr6:116678345
chr2:3171809
chr5:159409183
chr5:159425080
chr1:229156761
chr1:229108707
chr2:3362545
chr11:43379671
chr11:43421492
chr11:43385591
chr11:43429389
chr11:43383663
chr17:15869086
chr17:15872746
chr2:32781430
chr21:37382487
chr2:74571304
chr2:74564044
chr5:94831285
chr5:94839858
chr5:94878511
chr22:45048594
chr14:70204058
chr14:70209015
chr1:117446471
chr1:117446472
chr3:9845644
chr3:9836868
chr3:9851962
chr3:9852063
chr2:219320123
chr2:219320620
chr2:219325818
chr2:219323031
chr2:219320598
chr14:75418959
chr14:75490797
chr6:24759129
chr7:2670787
chr2:219823757
chr2:219823647
chr2:219823746
chr2:219823379
chr2:219823744
chr2:219823747
chr12:47953350
chr12:47953351
chr22:16993661
chr6:3098927
chr6:3172731
chr6:3169822
chr6:3169832
chr6:3169833
chr9:139257264
chr9:139257297
chr17:38019201
chr10:134947452
chr15:20421386
chr15:20423847
chr15:20400374
chr22:49007379
chr22:49001977
chr16:28761607
chr16:28761608
chr16:28761609
chr3:50362103
chr3:50362452
chr11:62090860
chr11:62090863

TRIP13
TRIP4
TRIT1
TRIT1
TRIT1
TRMT112
TRMT2A
TRMT61A
TRNAU1AP
TRNT1
TROAP
TROAP
TROVE2
TRPT1
TRRAP
TRRAP
TRRAP
TSC1
TSC1
TSEN34
TSN
TSN
TSPAN14
TSPAN14
TSPAN31
TSPAN31
TSPYL1
TSPYL5
TSSC1
TTC1
TTC1
TTC13
TTC13
TTC15
TTC17
TTC17
TTC17
TTC17
TTC17
TTC19
TTC19
TTC27
TTC3
TTC31
TTC31
TTC37
TTC37
TTC37
TTC38
TTC9
TTC9
TTF2
TTF2
TTLL3
TTLL3
TTLL3
TTLL3
TTLL4
TTLL4
TTLL4
TTLL4
TTLL4
TTLL5
TTLL5
TTRAP
TTYH3
TUBA1
TUBA1
TUBA1
TUBA1
TUBA1
TUBA1
TUBA1C
TUBA1C
TUBA8
TUBB2A
TUBB2B
TUBB2B
TUBB2B
TUBB2B
TUBB2C
TUBB2C
TUBG1
TUBGCP2
TUBGCP5
TUBGCP5
TUBGCP5
TUBGCP6
TUBGCP6
TUFM
TUFM
TUFM
TUSC4
TUSC4
TUT1
TUT1

UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR5
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
mixed
UTR3
UTR3
mixed
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
coding_exon
coding_exon
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
mixed
mixed
coding_exon
coding_exon

ENST00000261884:RtoS;
ENST00000046894:TtoP;ENST00000316891:TtoP;ENST00000372818:TtoP;ENST000

ENST00000252136:StoC;ENST00000403707:StoC;ENST00000404751:StoC;ENST000

ENST00000380327:PtoL;
ENST00000257909:LtoQ;

ENST00000355540:TtoS;ENST00000359863:TtoS;ENST00000446306:TtoS;
ENST00000355540:LtoM;ENST00000359863:LtoM;ENST00000446306:LtoM;
ENST00000298552:MtoI;ENST00000440111:MtoI;

ENST00000257910:GtoE;

ENST00000231238:LtoP;
ENST00000366661:VtoL;ENST00000366662:VtoL;ENST00000414259:VtoL;

ENST00000039989:VtoA;ENST00000299240:VtoA;
ENST00000039989:NtoD;ENST00000299240:NtoD;
ENST00000039989:LtoH;ENST00000299240:LtoH;
ENST00000039989:KtoQ;
ENST00000261647:LtoS;ENST00000395886:LtoS;
ENST00000317907:LtoP;
ENST00000233623:LtoR;ENST00000410003:LtoR;ENST00000441635:LtoR;ENST000
ENST00000358746:VtoG;

ENST00000381031:QtoL;ENST00000445282:QtoL;
ENST00000256367:VtoA;

ENST00000336674:NtoK;ENST00000383827:NtoK;ENST00000397241:NtoK;ENST00

ENST00000258398:WtoG;ENST00000392102:WtoG;ENST00000457313:WtoG;
ENST00000258398:VtoD;ENST00000392102:VtoD;ENST00000442769:VtoD;ENST00
ENST00000258398:QtoL;ENST00000392102:QtoL;ENST00000442769:QtoL;ENST000
ENST00000258398:LtoI;ENST00000392102:LtoI;ENST00000442769:LtoI;ENST00000
ENST00000258398:KtoQ;ENST00000392102:KtoQ;ENST00000442769:KtoQ;ENST00
ENST00000286653:EtoG;ENST00000298832:EtoG;ENST00000393826:EtoG;ENST000
ENST00000341060:FtoV;ENST00000378198:FtoV;
ENST00000248437:VtoG;ENST00000332858:*toE;ENST00000392088:VtoG;
ENST00000248437:StoG;ENST00000392088:StoG;
ENST00000248437:PtoT;ENST00000392088:PtoT;
ENST00000248437:EtoG;ENST00000392088:EtoG;

ENST00000316027:KtoE;ENST00000330423:KtoE;
ENST00000259818:ItoL;

ENST00000340384:VtoA;
ENST00000340384:GtoD;
ENST00000251413:DtoG;
ENST00000252936:VtoA;ENST00000368562:VtoA;ENST00000368563:VtoA;ENST00
ENST00000283645:VtoL;ENST00000453949:VtoL;
ENST00000283645:StoT;ENST00000453949:StoT;
ENST00000283645:LtoP;ENST00000453949:LtoP;
ENST00000248846:YtoS;ENST00000413101:YtoS;ENST00000439308:YtoS;
ENST00000248846:StoA;ENST00000413101:StoA;ENST00000439308:StoA;

ENST00000329251:PtoR;ENST00000378019:PtoR;ENST00000424909:PtoA;
ENST00000329251:LtoP;ENST00000378019:LtoP;ENST00000424909:CtoR;

138

+
+

+
+
+
+
+
+

+
+
+

+
+
+
+
+
+
+

+
+

+
+
+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+

+
+
+

+
+
+

AtoG
GtoT
AtoC
TtoC
GtoC
CtoT
CtoG
TtoC
TtoC
TtoC
CtoT
TtoA
TtoC
AtoT
AtoT
CtoA
GtoA
GtoT
AtoC
TtoC
TtoC
TtoC
AtoC
TtoG
GtoA
TtoC
TtoC
TtoC
TtoC
TtoC
TtoC
GtoC
TtoC
CtoA
TtoC
AtoG
TtoA
AtoC
TtoA
TtoC
TtoC
TtoC
AtoC
TtoG
AtoG
TtoG
AtoG
TtoC
AtoT
TtoC
TtoG
AtoT
CtoG
CtoG
GtoA
TtoG
CtoG
TtoG
TtoA
AtoT
CtoA
AtoC
AtoG
AtoC
TtoG
AtoG
TtoG
AtoG
CtoA
AtoG
CtoT
TtoC
TtoA
AtoG
AtoG
TtoA
AtoC
CtoT
TtoC
CtoA
TtoC
GtoA
AtoG
TtoC
GtoC
TtoA
TtoC
AtoC
TtoG
CtoA
GtoA
AtoG
AtoC
TtoA
CtoG
TtoC

0.1
0.1
0.1
0.2143
0.1
0.1053
0.1111
0.1538
0.4545
0.1
0.1
0.1333
0.1
0.1111
0.1
0.1
0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.125
0.1
0.1111
0.1
0.1333
0.1
0.1
0.3571
0.1
0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1429
0.1
0.1
0.1
0.1
0.1
0.1
0.1034
0.1
0.1
0.1333
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1333
0.1053
0.1019
0.1304
0.1
0.2
0.1875
0.1
0.1
0.2143
0.1875
0.1
0.1176
0.1739
0.1
0.1111
0.1026
0.1
0.1
0.1
0.1
0.1
0.4706
0.5217
0.1304
0.1
0.1
0.1111
0.1579

0.1818
0.1
0.3
0.25
0.1
0.2
0.1333
0.1667
0.5
0.125
0.1
0.1667
0.1429
0.5
0.1429
0.1
0.1818
0.1
0.1
0.125
0.1111
0.2
0.2
0.1
0.1111
0.1176
0.4
0.1
0.2143
0.1176
0.1944
0.1
0.1
0.5833
0.1
0.25
0.1
0.1111
0.1176
0.1
0.1
0.1111
0.1333
0.1
0.1818
0.25
0.1053
0.2
0.1
0.1333
0.25
0.1538
0.1892
0.2
0.5
0.2143
0.2
0.1
0.1538
0.1053
0.1
0.1111
0.1
0.2
0.3077
0.1053
0.1579
0.15
0.1111
0.1161
0.1818
0.1429
0.3333
0.4167
0.1429
0.1
0.2941
0.6
0.3171
0.122
0.2188
0.2
0.125
0.1379
0.25
0.1
0.1
0.1
0.1
0.8
0.9412
0.2727
0.1538
0.1
0.2
0.2252

5
2
6
3
2
4
3
2
3
5
2
3
3
3
5
2
2
2
2
7
4
2
2
2
2
3
4
2
2
9
8
2
3
2
3
5
3
3
3
2
5
3
2
3
2
7
2
5
3
3
3
3
2
6
2
2
2
4
3
5
3
4
2
2
2
2
5
3
4
2
6
11
3
5
2
2
2
10
9
5
7
2
2
8
3
2
2
4
2
4
9
13
2
2
5
8

3
2
5
2
2
2
2
2
3
2
2
2
3
3
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
4
2
2
2
2
3
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
3
4
2
5
2
2
2
10
8
2
2
2
2
2
2
2
2
2
2
4
9
9
2
2
3
3

[10,19]
[10,10]
[10,19]
[12,14]
[10,11]
[10,21]
[15,18]
[12,13]
[20,41]
[10,16]
[10,10]
[12,15]
[10,14]
[13,18]
[20,21]
[10,10]
[11,13]
[10,10]
[10,10]
[16,20]
[10,18]
[10,10]
[10,10]
[10,10]
[18,18]
[17,30]
[10,32]
[10,10]
[10,14]
[11,34]
[15,36]
[10,10]
[10,10]
[12,14]
[10,10]
[12,13]
[10,10]
[10,18]
[10,17]
[10,10]
[10,10]
[18,20]
[10,15]
[10,10]
[10,11]
[13,17]
[19,21]
[10,10]
[10,10]
[10,15]
[10,12]
[10,27]
[29,37]
[10,25]
[10,18]
[15,15]
[10,10]
[10,10]
[10,13]
[10,19]
[10,10]
[10,18]
[10,10]
[10,10]
[13,17]
[19,20]
[10,19]
[21,32]
[19,19]
[110,159]
[18,23]
[10,19]
[10,16]
[10,26]
[10,14]
[10,10]
[14,18]
[10,81]
[10,61]
[17,42]
[24,33]
[10,10]
[16,18]
[29,39]
[10,12]
[10,10]
[10,10]
[10,10]
[10,11]
[11,18]
[10,25]
[11,30]
[10,13]
[10,10]
[12,18]
[27,116]

TableS10

chr11:62100289
chr11:62100960
chr11:62100288
chr11:62083776
chr11:62083780
chr11:62083784
chr11:62083794
chr11:62083795
chr11:62083796
chr11:62083844
chr11:62083845
chr11:62083859
chr11:62083867
chr11:62083868
chr11:62083869
chr11:62083870
chr11:62097909
chr11:62083653
chr11:62083654
chr3:52231463
chr3:52231327
chr3:52232866
chr3:52237700
chr7:19710969
chr7:19703700
chr18:9386541
chr18:9391249
chr9:112046131
chr9:112046230
chr16:11732006
chr16:11680612
chr16:11732131
chr1:52271754
chr1:52258451
chr6:7826803
chr6:7826823
chr6:7826824
chr18:75834500
chr16:70685368
chr12:103267884
chr10:71573723
chr1:75003126
chr21:43387726
chr21:43386191
chr19:40927066
chr1:160835975
chr4:68182570
chr4:68166569
chr4:68166798
chr4:68167023
chr3:49822700
chr3:49823476
chr3:49822701
chr9:137976767
chr13:98744799
chr13:98745188
chr13:98836540
chr13:98836543
chr9:34241521
chr9:33931683
chr9:33912543
chr9:33961733
chr9:33979112
chr9:33911857
chr1:152493139
chr1:152509609
chr1:152509844
chr12:123963624
chr12:123965130
chr20:43875250
chr5:138987384
chr4:103936250
chr7:43958911
chr3:23907153
chr3:23907154
chr3:23907462
chr3:23907801
chr2:181635945
chr21:45013514
chr21:45015596
chr1:1181354
chr4:39456637
chr4:39456704
chr4:39457196
chr4:39460063
chr22:20306124
chr22:20306287
chr22:20307187
chr17:71913209
chr17:71906596
chr17:71897481
chr17:71898341
chr1:152788695
chr15:73970362
chr15:73978852
chr15:73979041

TUT1
TUT1
TUT1
TUT1
TUT1
TUT1
TUT1
TUT1
TUT1
TUT1
TUT1
TUT1
TUT1
TUT1
TUT1
TUT1
TUT1
TUT1
TUT1
TWF2
TWF2
TWF2
TWF2
TWISTNB
TWISTNB
TWSG1
TWSG1
TXN
TXN
TXNDC11
TXNDC11
TXNDC11
TXNDC12
TXNDC12
TXNDC5
TXNDC5
TXNDC5
TXNL4A
TXNL4B
TXNRD1
TYSND1
TYW3
U2AF1
U2AF1
U2AF1L4
UAP1
UBA6
UBA6
UBA6
UBA6
UBA7
UBA7
UBA7
UBAC1
UBAC2
UBAC2
UBAC2
UBAC2
UBAP1
UBAP2
UBAP2
UBAP2
UBAP2
UBAP2
UBAP2L
UBAP2L
UBAP2L
UBC
UBC
UBE2C
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E1
UBE2E1
UBE2E1
UBE2E3
UBE2G2
UBE2G2
UBE2J2
UBE2K
UBE2K
UBE2K
UBE2K
UBE2L3
UBE2L3
UBE2L3
UBE2O
UBE2O
UBE2O
UBE2O
UBE2Q1
UBE2Q2
UBE2Q2
UBE2Q2

coding_exon
coding_exon
coding_exon
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
mixed
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR5
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
mixed
mixed
mixed
UTR3
coding_exon
mixed
mixed
coding_exon
UTR5
mixed
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3

ENST00000278279:StoF;ENST00000476907:StoF;
ENST00000278279:KtoT;ENST00000476907:KtoT;

ENST00000423623:QtoE;
ENST00000423623:LtoP;
ENST00000423623:LtoP;

ENST00000262120:KtoE;

ENST00000283033:YtoS;ENST00000356957:YtoS;ENST00000436567:YtoS;

ENST00000287078:ItoN;
ENST00000291552:GtoS;ENST00000380276:GtoS;ENST00000398137:GtoS;ENST000
ENST00000292879:KtoQ;ENST00000378975:KtoQ;ENST00000412391:KtoQ;

ENST00000333486:RtoG;
ENST00000333486:LtoP;
ENST00000371756:EtoD;

ENST00000271877:YtoD;ENST00000343815:YtoD;ENST00000361546:YtoD;ENST000

ENST00000339647:EtoV;

ENST00000319380:VtoA;
ENST00000319380:NtoT;

ENST00000267938:NtoK;ENST00000426727:NtoK;
ENST00000267938:*toE;ENST00000338677:LtoR;ENST00000426727:*toE;

139

+
+

+
+
+
+
+

+
+
+

+
+

+
+
+
+
+
+

+
+
+
+
+
+
+

+
+
+

CtoT
AtoC
CtoT
CtoG
GtoT
GtoA
AtoT
TtoA
GtoA
GtoT
GtoC
CtoT
GtoC
GtoT
AtoC
CtoT
CtoT
TtoG
AtoG
CtoG
TtoC
TtoC
TtoC
CtoA
AtoG
AtoG
TtoC
TtoG
AtoG
AtoC
AtoC
TtoC
GtoT
AtoG
AtoG
TtoA
TtoC
GtoA
GtoC
AtoG
TtoA
GtoA
GtoA
CtoA
AtoC
AtoG
AtoC
TtoA
TtoG
TtoA
CtoG
TtoC
CtoA
GtoT
AtoG
AtoG
TtoG
AtoC
AtoT
TtoA
TtoC
TtoG
AtoG
GtoA
TtoG
TtoC
GtoA
AtoT
TtoG
TtoC
AtoG
TtoA
AtoG
TtoA
TtoA
TtoA
CtoA
TtoA
AtoG
CtoT
AtoG
TtoA
AtoT
AtoG
TtoC
TtoA
GtoA
TtoA
TtoC
AtoC
CtoA
GtoA
TtoC
TtoA
TtoG
TtoG

0.1
0.16
0.1176
0.1562
0.1224
0.1167
0.1154
0.12
0.14
0.1168
0.1441
0.1176
0.12
0.2143
0.25
0.1
0.1143
0.2105
0.1
0.1
0.1538
0.1
0.1538
0.1
0.1
0.125
0.1
0.1
0.1205
0.1
0.1724
0.1
0.1
0.1
0.1
0.1
0.125
0.1053
0.5
0.1429
0.1
0.1
0.125
0.1
0.1
0.1
0.1
0.125
0.1
0.1
0.1111
0.1154
0.1
0.1
0.1
0.1163
0.1053
0.1111
0.1
0.1
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.1
0.5
0.1
0.1
0.1
0.1
0.1429
0.1053
0.1053
0.2143
0.1429
0.125
0.1
0.125
0.1111
0.1
0.1
0.1
0.122
0.2
0.1
0.1429
0.1
0.1
0.1
0.1
0.1
0.1
0.1

0.125
0.1852
0.12
0.1667
0.2353
0.1515
0.6701
0.5161
0.2097
0.3849
0.487
0.16
0.2432
0.6364
0.5714
0.1111
0.1429
0.8
0.2455
0.125
0.2222
0.1
0.2941
0.3636
0.1364
0.1429
0.2
0.1667
0.1562
0.1818
0.2
0.1
0.1
0.125
0.1538
0.15
0.2174
0.1607
0.7143
0.1538
0.1
0.1667
0.2
0.1111
0.1364
0.1
0.1
0.1429
0.1176
0.2
0.1667
0.1875
0.15
0.3636
0.1875
0.1875
0.1333
0.1818
0.1818
0.1
0.1875
0.2727
0.1538
0.25
0.15
0.1
0.1429
0.3571
0.5207
0.1538
0.2
0.1
0.1429
0.175
0.1818
0.1176
0.3636
0.1818
0.1282
0.125
0.1333
0.1429
0.1
0.1818
0.1
0.1429
0.4
0.1818
0.1429
0.1818
0.1364
0.1818
0.1
0.1818
0.2143
0.1538

4
2
3
5
8
4
12
7
7
15
15
5
12
10
6
2
4
14
11
2
5
3
2
2
4
2
3
4
6
2
3
3
2
8
4
4
5
15
3
4
2
2
4
7
2
2
2
3
7
3
4
7
3
3
5
3
8
4
2
6
4
2
3
2
2
3
3
2
2
8
7
6
2
12
3
2
3
2
11
3
6
4
2
4
4
8
5
3
4
2
5
3
3
2
3
2

3
2
2
2
4
3
10
7
3
14
14
2
8
10
5
2
2
12
5
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
3
9
2
2
2
2
3
3
2
2
2
2
2
3
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
5
2
2
6
2
2
2
2
2
2
2
2
2
3
2
2
3
3
2
2
2
2
2
2
2
2

[10,24]
[25,27]
[17,25]
[13,33]
[18,57]
[34,61]
[22,206]
[15,88]
[54,237]
[46,281]
[47,262]
[17,25]
[23,40]
[11,26]
[10,15]
[10,11]
[15,36]
[11,45]
[11,114]
[10,16]
[10,13]
[10,10]
[13,18]
[10,11]
[10,22]
[14,16]
[10,15]
[11,12]
[32,83]
[10,11]
[11,29]
[10,10]
[10,10]
[10,17]
[11,13]
[10,20]
[11,23]
[15,56]
[14,22]
[13,14]
[10,10]
[12,20]
[15,16]
[10,20]
[10,22]
[10,10]
[10,10]
[14,17]
[10,17]
[10,13]
[12,28]
[16,26]
[10,20]
[10,11]
[10,16]
[16,86]
[16,19]
[11,18]
[10,11]
[10,10]
[16,30]
[11,15]
[10,13]
[10,16]
[10,20]
[10,20]
[10,15]
[10,15]
[216,218]
[10,18]
[12,30]
[10,10]
[10,14]
[12,41]
[12,19]
[17,19]
[11,14]
[11,14]
[24,39]
[11,16]
[15,16]
[10,14]
[10,10]
[10,11]
[10,10]
[28,41]
[10,12]
[10,12]
[14,15]
[10,11]
[10,22]
[10,11]
[10,10]
[10,22]
[10,14]
[10,13]

TableS10

chr9:33907951
chr9:33907971
chr9:33908120
chr9:33908167
chr9:33909509
chr9:33909906
chr19:60604496
chr8:49136065
chr8:49136622
chr17:44361069
chr17:44361072
chr15:23135408
chr12:108456956
chr12:108425340
chr11:117755577
chr11:117741019
chr11:117749520
chr1:10109491
chr1:10162617
chr16:23485812
chr16:23491807
chr16:23493091
chr1:11268804
chr1:11270684
chr19:9801782
chr19:9801792
chr16:4850859
chr16:4860319
chr16:4872304
chr20:3075395
chr20:3075399
chr20:3075673
chr3:33419376
chr9:85464773
chr9:85465140
chr9:85465645
chr9:85465823
chr9:85466238
chr9:85466244
chr15:41031783
chr6:42734521
chr1:19313988
chr1:19338300
chr1:19349698
chr1:19354011
chr1:19367221
chr8:103380890
chr8:103334916
chr8:103335331
chr8:103335333
chr8:103335340
chr5:171571571
chr5:171570809
chr17:39638194
chr17:39638439
chr11:62200556
chr11:62200558
chr2:136256946
chr19:4396026
chr3:197579392
chr3:197560125
chr3:197563393
chr3:197565587
chr3:197566737
chr3:197567808
chr9:133389038
chr9:133389205
chr1:164147043
chr1:159390403
chr1:159390405
chr4:186573326
chr4:186576644
chr9:113734421
chr9:113735965
chr2:128644385
chr2:128665458
chr2:128665459
chr2:128665548
chr2:128667961
chr2:128667962
chr2:128667981
chr2:128668146
chr4:39182503
chr4:39183718
chr4:39177391
chr1:160759243
chr1:160760238
chr1:160765056
chr6:34958759
chr6:34958835
chr9:6467643
chr9:6467752
chr9:6496343
chr5:176317737
chr5:176264756
chr12:130972938

UBE2R2
UBE2R2
UBE2R2
UBE2R2
UBE2R2
UBE2R2
UBE2S
UBE2V2
UBE2V2
UBE2Z
UBE2Z
UBE3A
UBE3B
UBE3B
UBE4A
UBE4A
UBE4A
UBE4B
UBE4B
UBFD1
UBFD1
UBFD1
UBIAD1
UBIAD1
UBL5
UBL5
UBN1
UBN1
UBN1
UBOX5
UBOX5
UBOX5
UBP1
UBQLN1
UBQLN1
UBQLN1
UBQLN1
UBQLN1
UBQLN1
UBR1
UBR2
UBR4
UBR4
UBR4
UBR4
UBR4
UBR5
UBR5
UBR5
UBR5
UBR5
UBTD2
UBTD2
UBTF
UBTF
UBXN1
UBXN1
UBXN4
UBXN6
UBXN7
UBXN7
UBXN7
UBXN7
UBXN7
UBXN7
UCK1
UCK1
UCK2
UFC1
UFC1
UFSP2
UFSP2
UGCG
UGCG
UGCGL1
UGCGL1
UGCGL1
UGCGL1
UGCGL1
UGCGL1
UGCGL1
UGCGL1
UGDH
UGDH
UGDH
UHMK1
UHMK1
UHMK1
UHRF1BP1
UHRF1BP1
UHRF2
UHRF2
UHRF2
UIMC1
UIMC1
ULK1

UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
mixed
mixed
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR5
UTR5
UTR5
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
coding_exon
mixed
mixed
mixed
mixed
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
UTR5
UTR5
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
mixed
mixed
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3

ENST00000232165:ItoN;ENST00000397954:ItoN;ENST00000438097:ItoN;
ENST00000342494:FtoV;ENST00000434735:FtoV;
ENST00000252108:VtoG;ENST00000431736:VtoG;
ENST00000252108:EtoG;ENST00000431736:EtoG;
ENST00000253251:LtoP;ENST00000343090:LtoP;ENST00000377157:LtoP;
ENST00000219638:RtoQ;ENST00000395878:RtoQ;

ENST00000262376:LtoV;ENST00000396658:LtoV;

ENST00000283628:TtoP;ENST00000283629:TtoP;ENST00000447368:TtoP;

ENST00000372899:StoP;ENST00000372901:StoP;

ENST00000264689:GtoC;
ENST00000264689:EtoG;

ENST00000259253:VtoG;ENST00000375990:VtoG;

ENST00000316423:StoP;
ENST00000316423:ItoV;

ENST00000276893:DtoA;

ENST00000274827:TtoP;ENST00000323774:TtoP;ENST00000377219:TtoP;ENST000

140

+
+
+
+
+
+

+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+

+
+
+
+
+
+
+
+
+
+

+
+
+
+
+
+
+
+

TtoA
TtoG
CtoA
GtoT
AtoG
GtoA
TtoC
AtoG
TtoA
AtoT
GtoA
TtoA
TtoG
TtoA
TtoG
AtoG
TtoC
TtoC
AtoC
GtoA
TtoC
AtoG
TtoC
AtoT
TtoA
CtoA
TtoG
TtoC
TtoC
AtoT
TtoA
GtoT
AtoC
TtoA
AtoG
AtoG
TtoA
AtoG
TtoC
TtoG
TtoC
CtoA
TtoC
TtoG
TtoG
TtoC
TtoC
TtoC
TtoA
AtoG
AtoG
TtoC
TtoA
TtoC
GtoT
AtoG
TtoG
TtoC
AtoG
TtoC
TtoG
AtoG
TtoC
GtoA
TtoC
AtoG
CtoA
TtoA
TtoC
GtoC
GtoT
AtoG
AtoG
GtoC
TtoG
AtoC
CtoA
AtoC
AtoG
AtoG
AtoG
CtoT
TtoC
AtoG
TtoA
TtoG
TtoC
TtoA
TtoG
GtoC
AtoC
TtoA
AtoG
AtoC
AtoG
CtoT

0.1053
0.1
0.1
0.1
0.1
0.1
0.1111
0.1333
0.1176
0.1525
0.102
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1667
0.1
0.1
0.1111
0.1538
0.1053
0.1
0.1
0.1176
0.1
0.1429
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1
0.1429
0.1
0.1111
0.1282
0.1
0.1
0.125
0.1
0.1429
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1053
0.1
0.1667
0.1
0.1
0.1
0.1667
0.1818
0.1
0.1
0.1
0.1053
0.1
0.1429
0.1176
0.1
0.1
0.1
0.1026
0.1
0.1
0.1176
0.1
0.1429
0.1

0.1053
0.1
0.1
0.1
0.125
0.1429
0.1765
0.1818
0.125
0.1951
0.1463
0.1111
0.2
0.1111
0.1
0.1333
0.1
0.1818
0.1
0.1176
0.1304
0.1
0.1111
0.1
0.1429
0.3333
0.1
0.1111
0.3
0.125
0.1
0.1818
0.1765
0.125
0.1
0.2857
0.2222
0.1304
0.2
0.1
0.1538
0.1
0.1176
0.1667
0.1
0.1333
0.1765
0.2
0.1818
0.1818
0.1875
0.1538
0.1
0.1364
0.1
0.3636
0.1111
0.1333
0.1333
0.1
0.1176
0.1
0.1667
0.1
0.2
0.25
0.1
0.1053
0.1
0.125
0.2
0.1333
0.2143
0.6364
0.1538
0.1
0.1
0.2308
0.2
0.3
0.2857
0.1
0.1333
0.1053
0.2
0.1538
0.1
0.125
0.125
0.1379
0.1111
0.1176
0.1875
0.1538
0.2
0.1

3
2
2
3
2
3
4
3
7
2
4
6
4
2
2
2
2
5
2
2
3
2
2
3
5
5
3
4
2
4
2
2
4
5
5
5
5
3
7
2
2
2
4
2
2
2
2
8
2
5
11
2
5
8
2
6
10
4
5
2
2
2
5
3
3
4
2
2
4
4
4
3
5
2
3
3
3
2
4
4
4
3
2
4
2
4
2
2
3
3
3
12
6
4
3
2

2
2
2
2
2
2
2
2
2
2
3
2
3
2
2
2
2
2
2
2
2
2
2
2
2
4
2
2
2
2
2
2
2
2
2
5
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
4
4
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
4
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2

[19,19]
[10,10]
[10,10]
[10,10]
[17,20]
[10,14]
[17,18]
[11,15]
[16,17]
[41,59]
[41,49]
[10,18]
[10,10]
[10,10]
[10,10]
[10,15]
[10,10]
[10,11]
[10,10]
[10,17]
[18,23]
[10,30]
[10,18]
[10,10]
[10,14]
[10,14]
[10,10]
[10,10]
[11,12]
[10,16]
[10,10]
[11,18]
[13,17]
[16,19]
[10,10]
[10,14]
[10,17]
[10,23]
[10,14]
[10,10]
[10,13]
[10,10]
[10,17]
[12,17]
[10,10]
[10,15]
[18,30]
[14,15]
[10,11]
[11,18]
[16,42]
[10,13]
[10,10]
[17,22]
[10,10]
[11,27]
[10,11]
[10,15]
[10,15]
[10,10]
[10,17]
[10,10]
[10,18]
[10,10]
[10,10]
[10,12]
[10,10]
[10,20]
[10,10]
[16,19]
[10,20]
[15,19]
[10,29]
[12,33]
[10,13]
[10,10]
[10,10]
[12,13]
[10,11]
[10,10]
[10,15]
[10,10]
[15,19]
[10,19]
[10,21]
[13,17]
[10,10]
[10,16]
[10,16]
[29,39]
[10,10]
[10,17]
[17,18]
[10,14]
[10,14]
[10,10]

TableS10

chr17:23897898
chr12:119642517
chr12:119643422
chr12:119644454
chr12:119645409
chr15:89292383
chr7:866403
chr7:849655
chr22:37467521
chr19:18838385
chr10:12111023
chr10:12024748
chr10:12002929
chr13:114075083
chr11:118334142
chr19:1549046
chr19:1549049
chr1:46555033
chr5:132231273
chr5:132231279
chr21:32638838
chr1:227861653
chr9:130189970
chr1:159275769
chr19:40462472
chr4:76952367
chr1:62679833
chr1:62689705
chr18:201850
chr18:203566
chr12:61001528
chr21:29348066
chr21:29341218
chr21:29343014
chr9:131683148
chr1:159401311
chr1:159400606
chr17:20845949
chr17:20845950
chr17:20846416
chr1:55304792
chr21:16172871
chr11:113179779
chr11:113179802
chr11:113185176
chr15:61667673
chr15:61667625
chr15:61633032
chr17:55668306
chr1:77934329
chr1:77934594
chr2:61329192
chr2:61460860
chr2:61307751
chr2:61271269
chr2:61284927
chr2:61269637
chr11:77598785
chr17:74310156
chr17:74321540
chr4:144360913
chr4:144360912
chr4:144361071
chr2:85689195
chr3:49310394
chr3:49347937
chr3:49290593
chr3:49290596
chr11:11921087
chr1:21878313
chr1:21878317
chr10:11563873
chr10:11544797
chr10:11543644
chr16:8893522
chr15:48538595
chr15:48575461
chr15:48578726
chr15:48579099
chr5:72900123
chr12:100235527
chr12:100303985
chr8:117853115
chr4:71774729
chr6:144853857
chr6:145213839
chr11:75531073
chr11:75531161
chr11:75531210
chr2:106076917
chr2:106076273
chr16:69288661
chr12:6443526
chr12:6441902
chr17:8003892
chr1:7763942

UNC119
UNC119B
UNC119B
UNC119B
UNC119B
UNC45A
UNC84A
UNC84A
UNC84B
UPF1
UPF2
UPF2
UPF2
UPF3A
UPK2
UQCR
UQCR
UQCRH
UQCRQ
UQCRQ
URB1
URB2
URM1
USF1
USF2
USO1
USP1
USP1
USP14
USP14
USP15
USP16
USP16
USP16
USP20
USP21
USP21
USP22
USP22
USP22
USP24
USP25
USP28
USP28
USP28
USP3
USP3
USP3
USP32
USP33
USP33
USP34
USP34
USP34
USP34
USP34
USP34
USP35
USP36
USP36
USP38
USP38
USP38
USP39
USP4
USP4
USP4
USP4
USP47
USP48
USP48
USP6NL
USP6NL
USP6NL
USP7
USP8
USP8
USP8
USP8
UTP15
UTP20
UTP20
UTP23
UTP3
UTRN
UTRN
UVRAG
UVRAG
UVRAG
UXS1
UXS1
VAC14
VAMP1
VAMP1
VAMP2
VAMP3

UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
mixed
UTR3
UTR3
mixed
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
mixed
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
mixed
UTR3
UTR3
UTR3

ENST00000268159:CtoG;ENST00000394275:CtoG;ENST00000418476:CtoG;
ENST00000297445:DtoA;ENST00000389574:DtoA;ENST00000401592:DtoA;ENST00

ENST00000313977:LtoQ;ENST00000356352:LtoQ;ENST00000357604:LtoQ;ENST000

ENST00000351487:LtoI;ENST00000375299:LtoI;
ENST00000264031:StoP;

ENST00000382751:LtoP;
ENST00000258243:RtoG;

ENST00000339950:LtoP;ENST00000371146:LtoP;ENST00000433771:LtoP;

ENST00000334352:StoP;ENST00000399975:StoP;ENST00000399976:StoP;

ENST00000289865:PtoT;ENST00000368001:PtoT;ENST00000368002:PtoT;ENST000
ENST00000289865:LtoP;ENST00000368001:LtoP;ENST00000368002:LtoP;ENST0000

ENST00000003302:Kto*;ENST00000260188:Kto*;
ENST00000003302:HtoR;ENST00000260188:HtoR;
ENST00000268049:KtoQ;ENST00000380324:KtoQ;
ENST00000268049:KtoE;ENST00000380324:KtoE;
ENST00000300896:QtoR;

ENST00000263989:YtoN;ENST00000398569:YtoN;ENST00000398571:YtoN;ENST00
ENST00000263989:YtoC;ENST00000398569:YtoC;ENST00000398571:YtoC;ENST000
ENST00000263989:MtoK;ENST00000398569:MtoK;ENST00000398571:MtoK;ENST0
ENST00000263989:LtoH;ENST00000398569:LtoH;ENST00000398571:LtoH;ENST000
ENST00000263989:CtoR;ENST00000398569:CtoR;ENST00000398571:CtoR;ENST000
ENST00000263311:ItoV;ENST00000441408:ItoV;
ENST00000312010:KtoR;ENST00000449938:KtoR;
ENST00000312010:GtoV;ENST00000449938:GtoV;
ENST00000307017:AtoS;

ENST00000265560:VtoA;ENST00000351842:VtoA;

ENST00000277575:LtoP;ENST00000379237:LtoP;

ENST00000307179:TtoA;ENST00000396444:TtoA;ENST00000425032:TtoA;ENST000
ENST00000307179:GtoV;ENST00000396444:GtoV;ENST00000425032:GtoV;ENST00

ENST00000261637:QtoR;
ENST00000261637:KtoE;

ENST00000367545:KtoE;

ENST00000283148:StoR;ENST00000409032:StoR;ENST00000409501:StoR;
ENST00000261776:EtoK;

141

+
+
+
+
+
+
+

+
+

+
+
+

+
+

+
+
+
+
+
+
+
+
+
+
+
+
+

+
+
+

+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+

TtoC
GtoA
AtoG
TtoA
TtoA
TtoG
AtoC
AtoG
AtoT
TtoA
TtoA
TtoC
AtoG
CtoA
TtoC
TtoA
TtoC
AtoG
TtoC
CtoA
TtoC
AtoG
CtoA
AtoG
TtoG
AtoC
TtoC
GtoA
TtoA
AtoT
AtoG
TtoC
TtoA
TtoA
GtoT
CtoA
TtoC
TtoG
AtoT
TtoG
CtoA
AtoG
AtoT
AtoG
AtoG
AtoC
AtoG
AtoG
AtoG
GtoA
TtoA
TtoA
AtoG
TtoA
TtoA
TtoC
TtoC
AtoG
AtoG
GtoT
GtoT
TtoC
TtoC
CtoT
TtoC
TtoC
CtoA
AtoG
GtoA
GtoC
TtoA
TtoC
CtoA
CtoA
TtoC
AtoG
GtoT
TtoC
AtoC
TtoC
AtoG
AtoG
TtoC
TtoA
AtoG
GtoA
TtoC
AtoG
AtoG
CtoA
GtoA
GtoA
TtoG
TtoC
TtoA
TtoC

0.125
0.1
0.1
0.1
0.1
0.1071
0.1
0.1
0.1667
0.1538
0.1
0.1053
0.1
0.1765
0.1
0.1111
0.1
0.1034
0.1
0.5833
0.1
0.1
0.1
0.1091
0.125
0.1
0.1316
0.1
0.1176
0.1
0.1
0.125
0.1
0.1
0.1
0.1
0.1111
0.1765
0.2105
0.1176
0.1
0.1
0.1
0.1
0.1176
0.1333
0.125
0.1
0.1333
0.1
0.1
0.1053
0.1
0.1
0.1
0.125
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.125
0.2727
0.1
0.1111
0.1053
0.1111
0.1
0.1
0.1
0.1
0.1
0.2
0.1111
0.1
0.1
0.1538
0.1
0.1538
0.1
0.1
0.1
0.4038
0.1
0.1154
0.1
0.1
0.1
0.1333
0.1
0.1
0.1

0.14
0.1
0.1333
0.1
0.1
0.1379
0.1
0.1
0.1667
0.1818
0.1
0.1875
0.1053
0.2
0.1818
0.5
0.125
0.1579
0.1683
0.9565
0.1111
0.1818
0.1
0.3077
0.175
0.1429
0.1579
0.1
0.2308
0.1
0.1538
0.1538
0.1
0.1429
0.1
0.1
0.125
0.2
0.2222
0.2353
0.1818
0.1333
0.1
0.1053
0.1538
0.1667
0.2
0.1429
0.2
0.1667
0.1111
0.2
0.1
0.1
0.1111
0.1333
0.1
0.2
0.2857
0.1
0.125
0.1538
0.1
0.125
0.2
0.1333
0.3077
0.1429
0.1765
0.125
0.1176
0.1429
0.1333
0.1
0.1
0.1053
0.2
0.1538
0.125
0.1111
0.2
0.1
0.1538
0.2222
0.1
0.125
0.5435
0.125
0.1765
0.1176
0.1176
0.1
0.1765
0.1333
0.1053
0.1

13
2
2
4
4
8
3
2
3
9
2
7
2
4
3
14
6
14
21
10
5
2
2
7
3
4
5
2
6
2
3
5
2
4
3
2
6
2
3
2
2
4
5
2
2
4
3
2
6
3
2
2
2
3
2
4
4
2
5
2
4
3
3
4
7
3
3
3
5
2
3
2
3
2
2
3
2
2
2
2
2
2
2
2
2
2
3
4
2
4
4
3
6
5
3
3

2
2
2
2
2
5
2
2
2
2
2
2
2
2
2
12
3
7
9
10
2
2
2
2
3
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
5
2
2
2
2
2
3
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
3
2
2

[16,51]
[10,10]
[10,15]
[10,10]
[10,10]
[17,34]
[10,10]
[10,10]
[12,12]
[11,14]
[10,10]
[17,19]
[10,20]
[10,17]
[10,11]
[10,25]
[32,55]
[19,78]
[44,181]
[10,24]
[10,20]
[10,11]
[10,10]
[13,61]
[23,80]
[14,20]
[13,38]
[10,20]
[13,17]
[10,10]
[10,13]
[13,16]
[10,10]
[10,14]
[10,10]
[10,10]
[16,18]
[20,34]
[19,36]
[17,17]
[10,11]
[10,16]
[10,10]
[10,19]
[13,17]
[12,15]
[10,16]
[14,20]
[10,15]
[10,12]
[10,18]
[10,19]
[10,10]
[10,10]
[10,18]
[15,16]
[10,20]
[10,10]
[10,17]
[10,10]
[10,16]
[10,13]
[10,10]
[16,20]
[17,25]
[15,24]
[11,13]
[10,14]
[17,18]
[16,19]
[17,18]
[10,14]
[10,15]
[10,10]
[10,10]
[10,19]
[10,10]
[13,18]
[10,16]
[10,18]
[10,14]
[10,10]
[13,13]
[10,10]
[10,10]
[10,16]
[41,53]
[10,16]
[18,26]
[10,17]
[10,17]
[10,10]
[15,17]
[10,19]
[10,19]
[10,10]

TableS10

chr2:85662660
chr18:9944453
chr18:9946548
chr20:56453317
chr6:31855000
chr6:31853295
chr1:211201216
chr1:211229083
chr1:211230888
chr17:38421074
chr17:38421078
chr19:6808303
chr10:75548065
chr10:75548070
chr10:75548345
chr9:35046558
chr9:35046559
chr5:133335505
chr5:133335507
chr10:76661042
chr12:46523451
chr6:43861518
chr17:53414251
chr12:94200455
chr3:11574200
chr3:11574486
chr3:10167484
chr6:159106766
chr6:159106767
chr6:159106768
chr6:159106938
chr6:159106946
chr6:159107351
chr6:159107353
chr6:159107865
chr6:159107869
chr7:65058004
chr6:133115319
chr6:133112676
chr22:22425173
chr11:118449156
chr9:79175641
chr9:79148957
chr9:79221924
chr15:59935848
chr15:59963741
chr1:12382911
chr20:2790498
chr15:38982702
chr15:38974338
chr15:38983228
chr2:86585374
chr10:70592265
chr10:70601993
chr10:70602196
chr10:70602468
chr11:133620758
chr8:145619817
chr15:89358076
chr15:89350915
chr15:89352198
chr16:45249577
chr13:51886706
chr11:60654544
chr15:40264099
chr15:40257947
chr15:40257770
chr15:40245254
chr15:40238205
chr15:40240051
chr15:40240191
chr7:38732163
chr1:148349275
chr1:148307414
chr17:451863
chr17:368529
chr2:58240005
chr2:58169009
chr2:58240371
chr19:55215713
chr6:142529113
chr6:142581753
chr6:142582297
chr10:114566744
chr11:60783195
chr10:28919740
chr10:28948876
chr10:88249736
chr10:88250260
chr10:88186996
chr14:99869879
chr14:99870601
chr1:119420524
chr1:119377362
chr1:119376964
chr2:74541517

VAMP8
VAPA
VAPA
VAPB
VARS
VARS
VASH2
VASH2
VASH2
VAT1
VAT1
VAV1
VCL
VCL
VCL
VCP
VCP
VDAC1
VDAC1
VDAC2
VDR
VEGFA
VEZF1
VEZT
VGLL4
VGLL4
VHL
VIL2
VIL2
VIL2
VIL2
VIL2
VIL2
VIL2
VIL2
VIL2
VKORC1L1
VNN2
VNN2
VPREB3
VPS11
VPS13A
VPS13A
VPS13A
VPS13C
VPS13C
VPS13D
VPS16A
VPS18
VPS18
VPS18
VPS24
VPS26A
VPS26A
VPS26A
VPS26A
VPS26B
VPS28
VPS33B
VPS33B
VPS33B
VPS35
VPS36
VPS37C
VPS39
VPS39
VPS39
VPS39
VPS39
VPS39
VPS39
VPS41
VPS45
VPS45
VPS53
VPS53
VRK2
VRK2
VRK2
VRK3
VTA1
VTA1
VTA1
VTI1A
VWCE
WAC
WAC
WAPAL
WAPAL
WAPAL
WARS
WARS
WARS2
WARS2
WARS2
WBP1

UTR3
UTR3
UTR3
UTR3
mixed
UTR3
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
coding_exon
mixed
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
mixed
UTR3
coding_exon
coding_exon
UTR3
UTR5
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
mixed
mixed
UTR3
UTR3
UTR3
coding_exon
mixed
UTR3
UTR3

ENST00000261219:QtoR;ENST00000397792:QtoR;ENST00000397796:QtoR;ENST00

ENST00000326499:TtoR;ENST00000335846:TtoR;ENST00000392389:TtoR;
ENST00000248948:StoP;ENST00000398465:StoP;
ENST00000355766:ItoV;ENST00000357409:ItoV;ENST00000360280:ItoV;ENST0000

ENST00000249837:WtoR;ENST00000261517:WtoR;
ENST00000249837:VtoM;ENST00000261517:VtoM;ENST00000395898:VtoM;
ENST00000380445:VtoA;
ENST00000220509:QtoH;
ENST00000220509:ItoT;

ENST00000263559:TtoS;ENST00000373382:TtoS;ENST00000395098:TtoS;

ENST00000333371:Rto*;
ENST00000333371:LtoR;
ENST00000333371:DtoG;

ENST00000318006:VtoG;ENST00000348544:VtoG;
ENST00000318006:StoP;ENST00000348544:StoP;
ENST00000318006:MtoL;ENST00000348544:MtoL;
ENST00000318006:LtoP;ENST00000348544:LtoP;

ENST00000369130:YtoN;
ENST00000369130:LtoR;

ENST00000340157:RtoS;ENST00000412104:RtoS;ENST00000423109:RtoS;ENST000
ENST00000340157:GtoV;ENST00000394539:GtoV;ENST00000412104:GtoV;ENST00

ENST00000301770:LtoP;ENST00000335613:LtoP;
ENST00000347934:TtoP;ENST00000354911:TtoP;ENST00000375646:TtoP;ENST000

ENST00000235521:EtoG;ENST00000369426:EtoG;

142

+
+
+
+

+
+
+

+
+
+
+

+
+
+
+

+
+
+
+
+

+
+
+
+
+

+
+

+
+
+

+
+
+
+

+
+

TtoC
TtoC
AtoG
AtoG
TtoG
AtoG
TtoA
AtoT
CtoA
TtoC
AtoG
AtoG
GtoA
CtoG
AtoG
CtoA
GtoA
AtoG
TtoC
CtoA
TtoC
TtoC
AtoG
AtoG
AtoG
AtoG
AtoG
GtoA
CtoA
AtoG
TtoA
TtoG
AtoG
AtoG
CtoT
GtoT
TtoA
CtoG
AtoG
TtoC
AtoT
AtoG
TtoC
TtoA
TtoC
GtoA
CtoG
TtoC
GtoT
TtoC
TtoC
CtoG
AtoT
TtoA
TtoA
TtoA
TtoG
TtoC
CtoT
TtoG
AtoG
TtoC
AtoC
GtoT
TtoG
TtoC
AtoT
TtoC
AtoG
AtoG
TtoG
GtoA
TtoA
TtoG
AtoG
AtoG
AtoT
GtoT
TtoC
GtoT
TtoC
AtoG
TtoC
GtoA
TtoC
AtoC
TtoC
CtoA
TtoA
TtoC
CtoA
AtoG
AtoG
TtoC
TtoC
GtoA

0.1
0.1
0.1
0.1
0.1154
0.1429
0.1
0.1
0.1429
0.1
0.1
0.1
0.1538
0.1
0.1
0.1111
0.1613
0.2222
0.1481
0.1071
0.1
0.1429
0.1
0.1333
0.1
0.1053
0.1538
0.1667
0.1818
0.1333
0.102
0.102
0.1034
0.1132
0.125
0.3256
0.1
0.1
0.1
0.125
0.1
0.1333
0.1333
0.1111
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1667
0.1
0.1
0.1053
0.1
0.1
0.1071
0.1
0.1
0.1
0.1176
0.1
0.1053
0.1
0.1333
0.1
0.1176
0.1
0.1
0.4167
0.1176
0.1
0.1
0.1
0.1
0.1
0.1818
0.1042
0.1
0.1053
0.1
0.1

0.3
0.1333
0.1
0.1667
0.1333
0.2
0.125
0.1
0.1818
0.1
0.1
0.1176
0.2
0.1818
0.1111
0.375
0.4762
0.4545
0.2
0.25
0.1
0.1429
0.1
0.1667
0.1
0.1333
0.1818
0.4375
0.6
0.25
0.1207
0.1613
0.1579
0.1607
0.44
0.4286
0.1
0.1
0.1333
0.2
0.1
0.1429
0.1667
0.1538
0.1333
0.1818
0.1
0.1154
0.1538
0.1
0.1053
0.1
0.1538
0.1
0.1538
0.2308
0.1
0.2
0.1
0.1
0.1053
0.1429
0.1
0.1
0.2
0.1
0.1667
0.1333
0.2
0.1
0.1111
0.1
0.1
0.1
0.1333
0.2
0.125
0.1
0.1538
0.1
0.1429
0.1
0.1538
0.4706
0.1818
0.1622
0.25
0.1
0.1667
0.125
0.5
0.122
0.2727
0.1304
0.1667
0.125

6
7
3
2
2
6
3
2
2
2
2
5
3
2
3
8
13
2
2
13
2
2
2
4
2
4
2
5
11
14
6
4
8
17
7
3
2
2
2
3
4
3
2
2
6
3
2
4
2
2
4
3
2
6
3
12
3
7
2
5
2
2
2
2
5
2
2
2
2
3
4
4
3
3
2
7
4
2
5
3
5
3
5
3
2
5
4
2
4
6
8
9
3
3
2
4

3
3
2
2
2
2
2
2
2
2
2
2
2
2
3
4
10
2
2
8
2
2
2
2
2
2
2
5
9
9
2
3
2
8
6
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
3
2
5
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
3
2
2
4
3
2
2
3
8
2
2
2
2
2

[10,16]
[10,16]
[10,10]
[10,12]
[30,52]
[15,28]
[10,16]
[10,10]
[11,14]
[10,10]
[10,10]
[17,20]
[10,13]
[10,11]
[10,18]
[11,18]
[15,31]
[10,11]
[15,28]
[12,29]
[10,10]
[14,14]
[10,10]
[12,15]
[10,10]
[15,19]
[11,13]
[12,19]
[10,19]
[12,24]
[49,58]
[31,49]
[19,29]
[48,161]
[21,40]
[16,43]
[10,10]
[10,10]
[10,15]
[15,16]
[10,10]
[14,15]
[12,15]
[13,18]
[16,19]
[10,11]
[10,10]
[10,26]
[10,13]
[10,10]
[10,19]
[10,10]
[10,13]
[10,10]
[13,19]
[10,13]
[10,10]
[15,81]
[10,10]
[10,10]
[10,19]
[10,14]
[10,10]
[10,10]
[11,20]
[10,30]
[10,12]
[15,19]
[10,10]
[10,10]
[18,28]
[10,20]
[10,10]
[10,10]
[15,17]
[10,10]
[19,24]
[10,10]
[14,16]
[10,11]
[17,21]
[10,20]
[10,13]
[12,17]
[11,17]
[20,41]
[10,18]
[10,10]
[10,18]
[10,18]
[10,16]
[41,97]
[10,12]
[19,23]
[10,12]
[10,16]

TableS10

chr12:14835457
chr13:40555106
chr7:72739087
chr2:224455014
chr2:224451226
chr13:51223550
chr10:49601539
chr10:49563048
chr14:54499297
chr14:54477941
chr19:945557
chr14:101745162
chr14:101745788
chr14:23662253
chr1:222688102
chr1:222643885
chr1:222643886
chr1:118278808
chr1:118286656
chr9:37851913
chr2:128198479
chr2:128196772
chr2:128239019
chr2:128177554
chr2:128180152
chr2:20001014
chr10:1160194
chr10:1166263
chr5:76772461
chr5:76764463
chr1:158456474
chr2:29011949
chr2:28982886
chr2:29023563
chr3:39113029
chr3:39111685
chr3:52155016
chr3:52134187
chr12:88337938
chr16:73509347
chr16:73515337
chr16:73495377
chr16:73479578
chr3:49024505
chr7:158376784
chr5:37515706
chr5:37432309
chr5:37788474
chr2:190048187
chr15:41919191
chr15:41921919
chr17:1580933
chr9:139578784
chr7:150705895
chr14:63135679
chr16:656120
chr16:655684
chr7:134524638
chr7:134524637
chr7:134519530
chr7:134519901
chr2:68218038
chr2:159813262
chr1:27507299
chr8:124517875
chr15:81296511
chr4:1952282
chr4:1953485
chr4:1954266
chr12:54581816
chr17:35688016
chr17:35688392
chr17:35689265
chr17:35689823
chr17:35691004
chr7:5237210
chr7:5237212
chr7:5237330
chr12:860397
chr12:793097
chr12:733498
chr12:850692
chr12:861482
chr12:888267
chr12:888667
chr12:889253
chr17:7546837
chr21:39685572
chr8:31144228
chr6:2730716
chr17:22664527
chr12:116955128
chr12:116955130
chr12:116956005
chr6:160097091
chr16:68479460

WBP11
WBP4
WBSCR22
WDFY1
WDFY1
WDFY2
WDFY4
WDFY4
WDHD1
WDHD1
WDR18
WDR20
WDR20
WDR23
WDR26
WDR26
WDR26
WDR3
WDR3
WDR32
WDR33
WDR33
WDR33
WDR33
WDR33
WDR35
WDR37
WDR37
WDR41
WDR41
WDR42A
WDR43
WDR43
WDR43
WDR48
WDR48
WDR51A
WDR51A
WDR51B
WDR59
WDR59
WDR59
WDR59
WDR6
WDR60
WDR70
WDR70
WDR70
WDR75
WDR76
WDR76
WDR81
WDR85
WDR86
WDR89
WDR90
WDR90
WDR91
WDR91
WDR91
WDR91
WDR92
WDSUB1
WDTC1
WDYHV1
WHAMM
WHSC1
WHSC1
WHSC2
WIBG
WIPF2
WIPF2
WIPF2
WIPF2
WIPF2
WIPI2
WIPI2
WIPI2
WNK1
WNK1
WNK1
WNK1
WNK1
WNK1
WNK1
WNK1
WRAP53
WRB
WRN
WRNIP1
WSB1
WSB2
WSB2
WSB2
WTAP
WWP2

coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
mixed
UTR5
coding_exon
UTR3
UTR3
coding_exon
coding_exon
mixed
mixed
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
mixed
UTR3
coding_exon
coding_exon
coding_exon
UTR3
mixed
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
mixed
coding_exon
mixed
mixed
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon

ENST00000261167:FtoV;
ENST00000265758:CtoW;ENST00000420399:CtoW;ENST00000423166:CtoW;ENST0
ENST00000233055:GtoE;ENST00000352510:GtoE;
ENST00000298125:EtoK;

ENST00000359167:Wto*;ENST00000360586:Wto*;ENST00000421192:Wto*;

ENST00000299135:HtoR;ENST00000335263:HtoR;ENST00000342702:HtoR;ENST00
ENST00000299135:Gto*;ENST00000335263:Gto*;ENST00000342702:Gto*;ENST00

ENST00000349139:RtoG;

ENST00000322313:KtoR;
ENST00000322313:KtoE;
ENST00000322313:HtoL;ENST00000393006:HtoL;ENST00000409658:HtoL;

ENST00000263150:NtoK;ENST00000358220:NtoK;ENST00000416775:NtoK;

ENST00000407426:LtoP;
ENST00000407426:CtoW;

ENST00000296484:FtoV;ENST00000394970:FtoV;ENST00000474012:FtoV;

ENST00000262144:VtoG;
ENST00000262144:KtoN;
ENST00000205064:VtoG;ENST00000262144:VtoG;
ENST00000205064:HtoR;ENST00000262144:HtoR;
ENST00000407559:VtoG;
ENST00000265107:StoP;

ENST00000277540:HtoR;

ENST00000293879:TtoS;ENST00000315764:TtoS;
ENST00000293879:NtoS;ENST00000315764:NtoS;
ENST00000326099:FtoS;ENST00000344400:FtoS;ENST00000354475:FtoS;ENST0000
ENST00000326099:FtoL;ENST00000344400:FtoL;ENST00000354475:FtoL;ENST0000

ENST00000295121:ItoK;ENST00000295122:ItoK;ENST00000406245:ItoK;ENST00000

ENST00000287387:DtoA;
ENST00000234505:VtoG;ENST00000286760:VtoG;

ENST00000315939:TtoA;ENST00000340908:TtoA;
ENST00000252477:QtoR;ENST00000315939:QtoR;ENST00000447667:QtoR;
ENST00000252477:PtoR;ENST00000315939:PtoR;ENST00000447667:PtoR;
ENST00000252477:AtoP;ENST00000315939:AtoP;ENST00000340908:AtoP;

ENST00000316024:StoP;ENST00000396463:StoP;ENST00000431639:StoP;ENST000

ENST00000356003:TtoP;ENST00000359154:TtoP;ENST00000448661:TtoP;

143

+
+

+
+
+

+
+
+
+

+
+
+

+
+

+
+
+
+
+

+
+
+
+
+
+
+
+
+

+
+

+
+
+
+
+

+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+

+
+

TtoG
AtoG
TtoG
GtoA
TtoG
GtoA
TtoG
TtoC
GtoA
TtoC
CtoA
AtoG
GtoT
CtoA
TtoG
TtoG
TtoC
AtoG
CtoA
GtoC
AtoG
AtoG
AtoT
AtoG
CtoA
TtoG
CtoA
CtoA
AtoG
TtoA
AtoG
TtoC
TtoG
GtoA
AtoG
TtoG
TtoG
TtoC
GtoA
TtoG
GtoT
TtoG
AtoG
TtoG
TtoG
TtoC
TtoA
TtoC
TtoA
AtoC
TtoC
CtoA
AtoG
AtoG
TtoA
CtoG
AtoG
TtoC
TtoA
TtoG
TtoC
TtoA
AtoT
TtoA
AtoC
TtoG
TtoC
TtoA
TtoC
TtoG
TtoC
GtoA
AtoG
TtoG
TtoC
AtoG
AtoG
TtoC
AtoG
AtoG
CtoG
GtoC
AtoG
TtoC
AtoC
TtoC
TtoC
TtoC
TtoC
TtoC
TtoC
CtoG
TtoG
TtoC
TtoA
AtoC

0.1
0.1
0.119
0.125
0.1111
0.1429
0.1
0.1
0.1053
0.1
0.16
0.1
0.1
0.1
0.1429
0.1111
0.1
0.1
0.1429
0.1
0.1
0.1
0.125
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1429
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.125
0.1176
0.1071
0.1
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1154
0.1071
0.1053
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.125
0.1143
0.1
0.1
0.1
0.1
0.1
0.1053
0.1333
0.1111
0.1
0.1053
0.1111
0.1538
0.1304
0.1
0.1111
0.5333
0.1176
0.1
0.1
0.1
0.1111
0.1
0.1333
0.1071
0.1
0.1

0.125
0.2143
0.129
0.1875
0.2143
0.3
0.1
0.1111
0.125
0.2
0.1818
0.1
0.1429
0.2333
0.1429
0.125
0.125
0.1538
0.2
0.1
0.1818
0.1
0.25
0.1
0.2
0.1
0.1
0.1
0.1538
0.1
0.1
0.1429
0.1818
0.1667
0.1176
0.1
0.125
0.1
0.1538
0.1429
0.1
0.1818
0.1333
0.2105
0.1
0.1667
0.1667
0.1429
0.125
0.1304
0.1111
0.1538
0.125
0.1111
0.2
0.1176
0.1818
0.1395
0.1628
0.1667
0.125
0.1667
0.1
0.1
0.1
0.1
0.125
0.125
0.2
0.7
0.1818
0.1
0.1176
0.1111
0.1818
0.1579
0.1429
0.1111
0.1
0.125
0.2
0.1905
0.1818
0.1818
0.1333
0.6667
0.1667
0.1053
0.2
0.2
0.1667
0.1429
0.1875
0.1333
0.1818
0.2143

9
4
9
3
3
4
4
2
2
4
3
2
2
6
2
3
3
3
6
2
2
2
4
3
3
3
2
2
9
3
2
2
3
2
2
2
3
2
2
7
4
3
6
4
2
3
5
7
5
3
4
2
4
6
2
3
3
9
8
4
2
4
2
3
2
2
3
4
4
2
3
3
6
3
2
6
3
3
2
5
2
5
8
4
2
3
3
6
2
4
3
2
2
2
4
3

2
2
3
2
3
2
2
2
2
2
2
2
2
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
4
3
2
2
2
2
3
2
2
3
2
4
2
2
3
2
2
2
2
2
2
3
2
2
2
2
2
2
3
2
2
2
2
2
2
3
2
2
3
2
2
2
2
2
2
2
2
2
3

[10,17]
[10,14]
[32,43]
[16,16]
[14,18]
[10,14]
[10,10]
[10,18]
[16,19]
[10,11]
[11,25]
[10,10]
[10,14]
[35,70]
[14,14]
[10,16]
[10,16]
[10,13]
[10,14]
[10,10]
[10,11]
[10,10]
[12,16]
[10,10]
[15,20]
[10,10]
[10,10]
[10,10]
[10,13]
[10,10]
[10,10]
[10,14]
[11,14]
[10,12]
[17,19]
[10,10]
[10,16]
[10,10]
[10,13]
[31,35]
[10,10]
[11,16]
[15,17]
[19,28]
[10,10]
[10,12]
[10,13]
[10,14]
[16,20]
[10,23]
[10,18]
[10,13]
[17,21]
[10,19]
[10,10]
[10,17]
[10,21]
[43,78]
[18,83]
[12,19]
[10,16]
[10,14]
[10,10]
[10,11]
[10,20]
[10,10]
[10,16]
[10,16]
[10,19]
[11,35]
[10,11]
[10,10]
[10,18]
[10,18]
[10,11]
[13,19]
[15,15]
[10,18]
[10,10]
[16,19]
[10,19]
[13,21]
[11,23]
[12,20]
[15,27]
[18,43]
[12,17]
[10,38]
[10,25]
[20,40]
[18,27]
[10,14]
[15,16]
[15,30]
[10,11]
[10,16]

TableS10

chr16:68500214
chr17:6604641
chr17:6617325
chr22:27520547
chr3:14172876
chr3:14175116
chr10:111630641
chr2:61573087
chr2:61582645
chr2:61618424
chr13:20271447
chr8:21919093
chr12:63128326
chr12:63128436
chr12:63128641
chr1:179060619
chr1:179120874
chr1:179121495
chr14:103243262
chr2:216778386
chr2:216779239
chr2:216682334
chr22:40389974
chr22:40389975
chr3:143513340
chr11:74230144
chr17:45793483
chr1:42935014
chr1:42935447
chr1:42935438
chr1:42935491
chr1:42935442
chr1:42935443
chr22:20312408
chr3:184952733
chr3:184952732
chr3:184986627
chr18:746699
chr19:43487887
chr19:43487598
chr2:32386216
chr5:143525295
chr5:143519163
chr5:143519949
chr7:44218718
chr7:44220123
chr14:74318071
chr1:38041920
chr4:68862400
chr4:68862406
chr5:112954796
chr20:61297592
chr20:61298365
chr20:61298366
chr17:1195095
chr17:1195352
chr17:1195353
chr7:75794539
chr22:30683342
chr14:99814191
chr14:99817006
chr22:36381969
chr20:43140205
chr20:43140622
chr6:34360625
chr14:64058309
chr14:64058968
chr6:151727342
chr6:33390372
chr14:64026892
chr14:64024018
chr19:40898247
chr19:40898744
chr19:40898882
chr3:142647519
chr3:142647514
chr3:142648706
chr17:7303719
chr17:7305208
chr17:7305735
chr1:22701478
chr11:129614934
chr11:129606810
chr1:6571666
chr1:6570948
chr9:37429528
chr19:3997533
chr1:32872237
chr1:32888721
chr1:202083159
chr1:202032052
chr1:202032061
chr6:149811911
chr6:149813084
chr14:88109084
chr2:187077158

WWP2
XAF1
XAF1
XBP1
XPC
XPC
XPNPEP1
XPO1
XPO1
XPO1
XPO4
XPO7
XPOT
XPOT
XPOT
XPR1
XPR1
XPR1
XRCC3
XRCC5
XRCC5
XRCC5
XRCC6
XRCC6
XRN1
XRRA1
XYLT2
YBX1
YBX1
YBX1
YBX1
YBX1
YBX1
YDJC
YEATS2
YEATS2
YEATS2
YES1
YIF1B
YIF1B
YIPF4
YIPF5
YIPF5
YIPF5
YKT6
YKT6
YLPM1
YRDC
YTHDC1
YTHDC1
YTHDC2
YTHDF1
YTHDF1
YTHDF1
YWHAE
YWHAE
YWHAE
YWHAG
YWHAH
YY1
YY1
Z83844.4
Z93016.1
Z93016.1
Z98036.1
ZBTB1
ZBTB1
ZBTB2
ZBTB22
ZBTB25
ZBTB25
ZBTB32
ZBTB32
ZBTB32
ZBTB38
ZBTB38
ZBTB38
ZBTB4
ZBTB4
ZBTB4
ZBTB40
ZBTB44
ZBTB44
ZBTB48
ZBTB48
ZBTB5
ZBTB7A
ZBTB8OS
ZBTB8OS
ZC3H11A
ZC3H11A
ZC3H11A
ZC3H12D
ZC3H12D
ZC3H14
ZC3H15

coding_exon
coding_exon
UTR3
UTR3
mixed
mixed
coding_exon
coding_exon
coding_exon
UTR5
coding_exon
UTR3
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR5
UTR3
UTR3
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
coding_exon
mixed
mixed
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
mixed
mixed
mixed
mixed
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
mixed
UTR3
coding_exon
mixed
coding_exon
UTR5
UTR5
UTR3
UTR3
coding_exon
coding_exon

ENST00000356003:NtoD;ENST00000359154:NtoD;ENST00000448661:NtoD;
ENST00000346752:KtoE;ENST00000348844:KtoE;ENST00000361842:KtoE;ENST000

ENST00000195419:KtoE;ENST00000401558:KtoE;ENST00000403576:KtoE;ENST000
ENST00000195419:ItoT;ENST00000401558:ItoT;ENST00000403576:ItoT;ENST00000
ENST00000255305:WtoR;ENST00000400602:WtoR;

ENST00000367589:GtoC;ENST00000367590:GtoC;

ENST00000352127:HtoQ;ENST00000440302:HtoQ;ENST00000445556:HtoQ;

ENST00000318612:NtoD;ENST00000321358:NtoD;
ENST00000318612:NtoD;ENST00000321358:NtoD;
ENST00000318612:GtoS;ENST00000321358:GtoS;
ENST00000318612:CtoY;ENST00000321358:MtoI;
ENST00000318612:AtoD;ENST00000321358:AtoD;

ENST00000305135:KtoT;ENST00000421660:KtoT;
ENST00000305135:KtoE;ENST00000421660:KtoE;

ENST00000274496:QtoH;ENST00000377986:QtoH;ENST00000448443:QtoH;

ENST00000161863:ItoV;

ENST00000358738:CtoS;

ENST00000261683:HtoR;ENST00000394715:HtoR;
ENST00000262630:QtoH;ENST00000392197:QtoH;
ENST00000262630:HtoP;ENST00000392197:HtoP;
ENST00000441582:ItoN;

ENST00000375647:LtoP;ENST00000404138:LtoP;

ENST00000377674:VtoA;
ENST00000377674:TtoA;

ENST00000373501:LtoP;ENST00000468695:LtoP;
ENST00000332127:QtoK;ENST00000367210:QtoK;ENST00000367212:QtoK;ENST00

ENST00000251038:StoP;ENST00000302216:StoP;ENST00000336693:StoP;ENST000
ENST00000337859:ItoS;

144

+
+
+

+
+
+
+
+
+
+

+
+
+
+
+

+
+
+
+
+
+
+

+
+
+

+
+
+

+
+
+

+
+
+
+
+

+
+
+
+
+
+

+
+

+
+
+

+
+

AtoG
AtoG
TtoG
GtoA
GtoC
TtoG
CtoT
AtoG
TtoC
GtoT
TtoC
AtoG
TtoC
TtoC
AtoG
GtoT
TtoG
GtoT
CtoA
AtoG
TtoA
AtoT
CtoA
CtoT
TtoA
TtoA
AtoG
AtoG
AtoG
GtoA
GtoA
CtoA
TtoA
TtoA
AtoC
AtoG
AtoG
GtoA
TtoG
AtoG
GtoT
AtoC
TtoC
TtoA
TtoG
CtoG
TtoC
CtoG
AtoG
TtoG
AtoG
AtoG
CtoG
CtoA
AtoG
GtoT
GtoT
TtoC
AtoG
AtoG
TtoA
AtoT
AtoG
CtoT
AtoG
TtoA
AtoG
AtoG
AtoG
AtoG
CtoG
GtoC
AtoC
GtoT
TtoA
AtoG
CtoT
TtoC
TtoC
AtoG
TtoC
TtoC
TtoC
TtoC
AtoG
TtoG
GtoA
TtoC
AtoT
CtoA
TtoA
GtoT
AtoG
TtoA
TtoC
TtoG

0.1
0.1
0.1
0.1304
0.2
0.125
0.4375
0.1053
0.1
0.1
0.1429
0.1111
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1176
0.1667
0.1
0.1034
0.1071
0.1
0.1
0.1
0.101
0.1
0.1111
0.1
0.1
0.1176
0.1
0.1111
0.1
0.1
0.1818
0.12
0.1
0.1
0.1053
0.1
0.125
0.1667
0.5319
0.1
0.1
0.1
0.1
0.1667
0.1176
0.1
0.1
0.1275
0.15
0.1
0.1
0.1429
0.1111
0.1
0.1176
0.2
0.1
0.1
0.1
0.1
0.1
0.1
0.1538
0.1
0.1
0.1053
1
0.1
0.1176
0.1
0.1667
0.1
0.1176
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1333
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1071

0.1429
0.1429
0.1667
0.1333
0.3077
0.1333
0.7083
0.1333
0.1111
0.1875
0.1667
0.1579
0.1667
0.1429
0.1667
0.1
0.1
0.1
0.1176
0.2
0.2308
0.1667
0.2903
0.2
0.1
0.1
0.1667
0.1011
0.2308
0.1282
0.2727
0.3077
0.1667
0.3158
0.2
0.1333
0.1429
1
0.125
0.1429
0.1
0.1176
0.1667
0.1818
0.2
0.5714
0.1667
0.1
0.1
0.1
0.1765
0.1429
0.1333
0.1333
0.1364
0.3793
0.2083
0.1429
0.1818
0.1875
0.1333
0.1364
0.2
0.1053
0.1
0.1053
0.1333
0.2
0.2
0.1667
0.1
0.1333
0.1707
1
0.1
0.3
0.1
0.2
0.1
0.2143
0.1
0.1667
0.1667
0.3
0.1
0.1
0.1364
0.1818
0.1
0.1538
0.1667
0.1
0.3333
0.1667
0.1
0.1818

2
5
5
2
3
5
2
7
4
6
2
10
5
2
3
2
2
2
2
12
8
3
10
8
3
3
2
11
4
13
8
9
11
4
7
3
4
7
4
5
2
2
2
2
2
2
2
2
2
8
4
5
3
3
11
6
8
2
6
7
3
8
2
3
2
2
4
6
4
4
2
8
4
13
2
8
3
4
5
2
2
2
2
2
2
2
6
5
2
5
3
2
5
3
4
3

2
2
2
2
3
2
2
2
2
3
2
4
4
2
2
2
2
2
2
4
3
2
7
6
2
2
2
2
2
4
5
5
3
2
3
2
2
6
2
3
2
2
2
2
2
2
2
2
2
2
2
3
2
2
2
6
5
2
2
3
2
2
2
2
2
2
3
2
2
2
2
3
2
13
2
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
5
2
2
3

[10,14]
[10,14]
[10,12]
[15,23]
[10,14]
[15,16]
[24,32]
[15,19]
[10,18]
[10,18]
[12,14]
[19,23]
[12,20]
[10,14]
[12,20]
[10,10]
[10,10]
[10,10]
[10,17]
[14,17]
[13,18]
[10,12]
[27,46]
[17,36]
[10,10]
[10,10]
[10,12]
[89,107]
[10,13]
[27,67]
[10,12]
[10,26]
[13,17]
[10,20]
[10,18]
[10,15]
[10,14]
[11,31]
[24,26]
[10,16]
[10,10]
[17,19]
[10,12]
[11,16]
[16,18]
[47,98]
[10,12]
[11,11]
[10,10]
[10,22]
[12,17]
[14,17]
[10,15]
[10,15]
[45,102]
[14,40]
[10,28]
[10,14]
[11,21]
[11,18]
[10,15]
[17,23]
[10,11]
[10,19]
[10,10]
[10,19]
[10,15]
[10,10]
[10,10]
[12,14]
[10,10]
[15,57]
[19,41]
[21,136]
[10,10]
[10,17]
[10,10]
[11,12]
[10,10]
[14,17]
[10,10]
[10,12]
[10,12]
[10,19]
[10,10]
[10,10]
[10,22]
[11,16]
[10,10]
[13,18]
[10,12]
[10,10]
[10,18]
[10,12]
[10,10]
[11,29]

TableS10

chr8:144691720
chr19:52259453
chr19:52259871
chr16:11768835
chr16:11766917
chr16:11764908
chr16:11772207
chr16:11752319
chr16:11752668
chr22:40072086
chr7:138414923
chr1:52684260
chr18:58396140
chr9:88128231
chr9:37344748
chr12:121524058
chr12:121528402
chr12:121532062
chr12:121523769
chr5:80644197
chr5:80636504
chr5:80636386
chr5:80644368
chr1:27051883
chr3:44943305
chr11:57222844
chr11:57196665
chr11:57196834
chr16:83566621
chr10:31850289
chr10:31824722
chr10:31831369
chr9:130555307
chr9:130537448
chr9:130554928
chr7:1159101
chr6:38229303
chr9:74156396
chr9:74156452
chr9:74156457
chr9:74159377
chr8:135665258
chr8:135665259
chr12:70290744
chr12:70290742
chr12:70290045
chr15:40527593
chr15:40518150
chr15:40492508
chr15:40495111
chr15:40495522
chr14:68326341
chr14:68326936
chr14:68324189
chr14:68324239
chr5:180207311
chr16:67157887
chr16:67158133
chr11:58134014
chr11:58138282
chr11:58141943
chr11:58141984
chr11:58142134
chr11:58144746
chr11:64608423
chr5:32431151
chr3:15098906
chr3:15086634
chr3:15087086
chr14:67317990
chr14:67284595
chr20:61810645
chr7:99470075
chr5:140066178
chr3:180218544
chr3:180224958
chr10:80745567
chr10:80746037
chr7:44774819
chr1:35643236
chr1:35637697
chr1:35657824
chr9:139596556
chr20:45271767
chr20:45272121
chr19:19649776
chr20:18244546
chr19:62824552
chr19:62824763
chr2:219215275
chr2:219215249
chr11:9452117
chr11:9452115
chr19:41419600
chr3:126435414
chr3:126435415

ZC3H3
ZC3H4
ZC3H4
ZC3H7A
ZC3H7A
ZC3H7A
ZC3H7A
ZC3H7A
ZC3H7A
ZC3H7B
ZC3HAV1
ZCCHC11
ZCCHC2
ZCCHC6
ZCCHC7
ZCCHC8
ZCCHC8
ZCCHC8
ZCCHC8
ZCCHC9
ZCCHC9
ZCCHC9
ZCCHC9
ZDHHC18
ZDHHC3
ZDHHC5
ZDHHC5
ZDHHC5
ZDHHC7
ZEB1
ZEB1
ZEB1
ZER1
ZER1
ZER1
ZFAND2A
ZFAND3
ZFAND5
ZFAND5
ZFAND5
ZFAND5
ZFAT
ZFAT
ZFC3H1
ZFC3H1
ZFC3H1
ZFP106
ZFP106
ZFP106
ZFP106
ZFP106
ZFP36L1
ZFP36L1
ZFP36L1
ZFP36L1
ZFP62
ZFP90
ZFP90
ZFP91
ZFP91
ZFP91
ZFP91
ZFP91
ZFP91
ZFPL1
ZFR
ZFYVE20
ZFYVE20
ZFYVE20
ZFYVE26
ZFYVE26
ZGPAT
ZKSCAN1
ZMAT2
ZMAT3
ZMAT3
ZMIZ1
ZMIZ1
ZMIZ2
ZMYM4
ZMYM4
ZMYM4
ZMYND19
ZMYND8
ZMYND8
ZNF101
ZNF133
ZNF134
ZNF134
ZNF142
ZNF142
ZNF143
ZNF143
ZNF146
ZNF148
ZNF148

coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
UTR5
UTR5
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
mixed
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR5
coding_exon
mixed
UTR3
UTR3
coding_exon
mixed
coding_exon
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon

ENST00000355758:Wto*;ENST00000396516:Wto*;
ENST00000355758:NtoD;ENST00000396516:NtoD;
ENST00000355758:CtoW;ENST00000396516:CtoW;

ENST00000242351:VtoA;ENST00000464606:VtoA;ENST00000471652:VtoA;

ENST00000277141:KtoE;ENST00000375960:KtoE;ENST00000375961:KtoE;ENST000
ENST00000336229:ItoK;

ENST00000254037:QtoR;ENST00000380199:QtoR;ENST00000407610:QtoR;ENST00
ENST00000254037:HtoN;ENST00000380199:HtoN;ENST00000407610:HtoN;ENST00

ENST00000374141:YtoS;ENST00000374142:YtoS;
ENST00000287169:TtoP;

ENST00000320985:TtoP;ENST00000437844:TtoP;ENST00000446923:TtoP;
ENST00000320985:RtoG;ENST00000446923:RtoG;
ENST00000320985:AtoD;ENST00000437844:AtoD;ENST00000446923:AtoD;
ENST00000291900:StoP;
ENST00000291900:LtoP;

ENST00000377838:DtoE;ENST00000429442:DtoE;
ENST00000377838:DtoA;ENST00000429442:DtoA;
ENST00000378743:DtoH;
ENST00000378743:DtoE;
ENST00000263805:QtoR;ENST00000434903:QtoR;
ENST00000263805:EtoK;ENST00000434903:EtoK;

ENST00000336440:TtoP;ENST00000435246:TtoP;ENST00000439696:TtoP;

ENST00000316059:RtoQ;
ENST00000316059:HtoR;

ENST00000265069:DtoA;ENST00000382126:DtoA;

ENST00000347230:GtoA;ENST00000411699:GtoA;
ENST00000328969:VtoE;ENST00000355969:VtoE;ENST00000357119:VtoE;ENST000

ENST00000314607:VtoG;ENST00000373297:VtoG;
ENST00000314607:QtoL;ENST00000373297:QtoL;
ENST00000314607:KtoE;ENST00000373297:KtoE;

ENST00000318110:TtoI;
ENST00000316358:EtoK;ENST00000377671:EtoK;ENST00000396026:EtoK;ENST000
ENST00000396161:HtoP;
ENST00000336124:HtoP;ENST00000396788:HtoP;ENST00000411696:HtoP;ENST00
ENST00000336124:AtoS;ENST00000396788:AtoS;ENST00000411696:AtoS;ENST000
ENST00000299606:YtoD;ENST00000396597:YtoD;ENST00000396602:YtoD;ENST000
ENST00000299606:AtoD;ENST00000396597:AtoD;ENST00000396602:AtoD;ENST00
ENST00000301233:KtoE;ENST00000428827:KtoE;ENST00000443387:KtoE;ENST000
ENST00000360647:DtoE;ENST00000484491:DtoE;ENST00000485866:DtoE;ENST000
ENST00000360647:DtoA;ENST00000484491:DtoA;ENST00000485866:DtoA;ENST00

145

+
+
+
+
+

+
+
+

+
+
+

+
+
+
+
+
+
+
+
+

+
+
+

+
+
+
+
+
+

+
+
+
+

+
+
+

TtoC
TtoC
TtoC
GtoA
AtoG
TtoG
TtoA
AtoG
TtoC
TtoG
TtoC
TtoG
TtoC
AtoG
TtoC
TtoA
AtoG
TtoA
TtoG
AtoG
CtoA
AtoG
AtoG
AtoC
TtoG
AtoC
TtoC
TtoA
TtoG
AtoC
AtoG
CtoA
TtoC
TtoC
CtoT
TtoC
TtoG
GtoA
AtoG
TtoC
TtoC
TtoA
AtoC
GtoC
TtoG
TtoC
AtoG
GtoA
TtoC
GtoT
TtoC
AtoC
TtoC
AtoC
TtoC
AtoC
CtoG
TtoC
GtoA
AtoG
TtoC
CtoA
TtoC
AtoG
TtoC
AtoC
AtoG
TtoC
AtoG
GtoC
AtoG
TtoA
TtoC
TtoA
TtoC
AtoG
TtoA
TtoC
CtoG
TtoG
AtoT
AtoG
GtoT
AtoG
GtoA
CtoT
GtoA
AtoC
AtoG
AtoC
GtoT
TtoG
CtoA
AtoG
CtoA
AtoC

0.1
0.1
0.1
0.1111
0.1
0.1026
0.1
0.1333
0.1111
0.1
0.1
0.1
0.1
0.1
0.1667
0.1333
0.1
0.1
0.1
0.1053
0.1
0.1176
0.1111
0.1053
0.1176
0.1111
0.1
0.1
0.1
0.1
1
0.1
0.1
0.1
0.1
0.1
0.1
0.8667
0.8
0.8824
0.2
0.1111
0.1111
0.1333
0.1111
0.1818
0.1
0.1
0.1
0.1111
0.1
0.1111
0.1
0.2
0.1
0.1
0.1
0.1
0.1333
0.1
0.1
0.1429
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1053
0.1111
0.1
0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1

0.1667
0.1333
0.1429
0.1579
0.1463
0.1282
0.125
0.1875
0.1818
0.2308
0.1
0.1429
0.1333
0.1429
0.1818
0.1818
0.1818
0.1
0.1
0.1667
0.1818
0.45
0.2222
0.3
0.125
0.2
0.2
0.1
0.1
0.1111
1
0.1
0.1538
0.1
0.1
0.2
0.1429
1
1
1
0.25
0.2143
0.2143
0.1667
0.2308
0.3
0.2308
0.1111
0.125
0.1667
0.2
0.1818
0.1067
0.4
0.2222
0.1
0.1
0.1
0.48
0.1111
0.1333
0.2
0.1
0.1
0.1481
0.1
0.1
0.1
0.1
0.1
0.1176
0.1333
0.1818
0.1111
0.1667
0.1818
0.1
0.1538
0.1111
0.1
0.1
0.125
0.1
0.1034
0.1579
0.1
0.1111
0.1053
0.1
0.2
0.1429
0.1429
0.1
0.125
0.1667
0.125

2
3
2
3
5
3
3
9
5
3
2
3
2
2
4
3
3
3
2
6
2
2
10
4
7
3
3
5
3
2
5
2
2
2
2
5
9
6
6
6
2
8
7
6
7
2
5
3
4
2
7
2
11
2
14
2
2
2
2
2
4
3
4
5
3
4
2
3
2
2
2
5
4
13
7
4
4
7
9
2
3
3
3
9
10
2
2
4
2
2
2
2
2
3
4
2

2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
4
2
2
4
2
2
2
2
2
2
2
5
2
2
2
2
2
3
6
6
6
2
4
2
3
5
2
3
2
2
2
2
2
4
2
8
2
2
2
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
2
3
2
4
2
2
2
2
2
2
5
2
2
2
2
2
2
2
2
2
3
2

[10,12]
[10,15]
[10,14]
[18,19]
[41,50]
[39,39]
[10,16]
[16,16]
[18,22]
[10,13]
[10,10]
[10,14]
[10,15]
[10,14]
[11,12]
[11,15]
[10,11]
[10,10]
[10,10]
[13,22]
[10,11]
[17,40]
[14,27]
[30,38]
[16,18]
[10,18]
[10,10]
[10,21]
[10,11]
[10,10]
[12,28]
[10,10]
[10,13]
[10,10]
[10,20]
[10,10]
[14,61]
[13,34]
[13,30]
[10,20]
[10,12]
[14,38]
[14,36]
[12,15]
[13,18]
[10,11]
[10,27]
[10,18]
[10,16]
[10,18]
[10,15]
[11,18]
[48,90]
[10,15]
[10,62]
[10,10]
[10,10]
[10,10]
[16,25]
[10,18]
[10,16]
[10,14]
[10,10]
[10,10]
[10,27]
[10,10]
[10,10]
[10,10]
[10,10]
[10,20]
[10,17]
[10,16]
[11,19]
[18,28]
[10,12]
[11,13]
[10,10]
[15,39]
[10,18]
[10,10]
[10,10]
[10,16]
[10,10]
[29,30]
[17,23]
[10,10]
[10,18]
[10,19]
[10,10]
[10,10]
[10,14]
[10,14]
[10,10]
[10,17]
[10,32]
[10,24]

TableS10

chr6:28303212
chr11:3336964
chr11:3337107
chr11:3337751
chr11:3337572
chr11:3337269
chr11:3338310
chr11:3336317
chr17:27732449
chr19:62845045
chr7:148583249
chr16:3132365
chr16:3132453
chr16:3132478
chr20:51626913
chr20:51631441
chr19:49304271
chr19:49368112
chr19:49366028
chr19:49424467
chr19:49431590
chr17:4953459
chr11:116154489
chr16:3280309
chr16:3280363
chr19:9385869
chr19:9385422
chr19:9406835
chr16:31833523
chr16:31804004
chr19:63415345
chr16:88332010
chr19:58262554
chr19:58263869
chr1:198644281
chr1:198642703
chr7:148553389
chr6:88024545
chr6:88026537
chr6:88029921
chr19:50266832
chr7:99511125
chr7:99505829
chr19:9127656
chr6:43415638
chr6:43432983
chr19:63676190
chr20:44015919
chr20:44019645
chr20:2399416
chr20:2399417
chr19:7490433
chr12:53049247
chr12:53049817
chr8:28259198
chr8:28259199
chr8:28259213
chr18:70906466
chr11:46682899
chr14:73430377
chr14:73457490
chr14:73458559
chr14:73468454
chr19:57495492
chr19:12600325
chr1:245558614
chr20:62076933
chr20:62134890
chr19:63465342
chr19:63465678
chr19:63449959
chr19:63466351
chr19:62601842
chr19:8784894
chr19:9315305
chr19:62982404
chr19:62982406
chr19:62982405
chr19:62982129
chr3:48277344
chr15:83142843
chr16:1989881
chr15:62754668
chr5:16504669
chr19:11590310
chr2:71515452
chr16:31000025
chr12:123062505
chr16:30983303
chr1:247110292
chr1:149526385
chr1:43090115
chr1:247118482
chr19:11921647
chr6:35368339
chr19:57487443

ZNF193
ZNF195
ZNF195
ZNF195
ZNF195
ZNF195
ZNF195
ZNF195
ZNF207
ZNF211
ZNF212
ZNF213
ZNF213
ZNF213
ZNF217
ZNF217
ZNF225
ZNF226
ZNF226
ZNF227
ZNF227
ZNF232
ZNF259
ZNF263
ZNF263
ZNF266
ZNF266
ZNF266
ZNF267
ZNF267
ZNF274
ZNF276
ZNF28
ZNF28
ZNF281
ZNF281
ZNF282
ZNF292
ZNF292
ZNF292
ZNF296
ZNF3
ZNF3
ZNF317
ZNF318
ZNF318
ZNF324
ZNF335
ZNF335
ZNF343
ZNF343
ZNF358
ZNF385A
ZNF385A
ZNF395
ZNF395
ZNF395
ZNF407
ZNF408
ZNF410
ZNF410
ZNF410
ZNF410
ZNF480
ZNF490
ZNF496
ZNF512B
ZNF512B
ZNF544
ZNF544
ZNF544
ZNF544
ZNF548
ZNF558
ZNF559
ZNF586
ZNF586
ZNF586
ZNF586
ZNF589
ZNF592
ZNF598
ZNF609
ZNF622
ZNF627
ZNF638
ZNF646
ZNF664
ZNF668
ZNF672
ZNF687
ZNF691
ZNF692
ZNF700
ZNF76
ZNF766

coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
coding_exon
UTR3
UTR3
UTR3
UTR3
mixed
mixed
mixed
coding_exon
UTR5
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR5
coding_exon
coding_exon
coding_exon
coding_exon
mixed
mixed
coding_exon
UTR3
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
mixed
mixed
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
mixed
mixed
mixed
UTR3
UTR3
UTR3
UTR3
UTR3
UTR3
coding_exon
mixed
mixed
mixed
UTR3
mixed
mixed
coding_exon
UTR5
UTR5
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
mixed
UTR5
mixed
coding_exon
mixed
coding_exon
coding_exon
coding_exon
UTR3

ENST00000252207:VtoG;ENST00000425468:VtoG;
ENST00000005082:QtoR;ENST00000343338:QtoR;ENST00000354599:QtoR;ENST00
ENST00000005082:KtoN;ENST00000343338:KtoN;ENST00000354599:KtoN;ENST00
ENST00000005082:KtoE;ENST00000343338:KtoE;ENST00000354599:KtoE;ENST000
ENST00000005082:EtoD;ENST00000343338:EtoD;ENST00000354599:EtoD;ENST000

ENST00000240731:KtoR;ENST00000299871:KtoR;ENST00000347302:KtoR;ENST000

ENST00000300823:AtoG;ENST00000337433:AtoG;ENST00000413984:AtoG;ENST00
ENST00000313040:VtoG;
ENST00000313040:FtoL;
ENST00000250076:VtoG;ENST00000381274:VtoG;ENST00000416429:VtoG;
ENST00000219069:KtoR;
ENST00000219069:ItoT;
ENST00000361151:EtoD;ENST00000361451:EtoD;ENST00000393865:EtoD;ENST000

ENST00000300870:QtoR;ENST00000394846:QtoR;
ENST00000300870:DtoA;ENST00000394846:DtoA;
ENST00000326804:EtoG;ENST00000345813:EtoG;ENST00000424679:EtoG;
ENST00000289816:HtoP;ENST00000443381:HtoP;ENST00000446326:HtoP;

ENST00000303809:HtoP;

ENST00000361428:LtoP;
ENST00000318149:CtoW;ENST00000361428:CtoW;
ENST00000322927:TtoA;ENST00000426788:TtoA;
ENST00000322927:GtoV;ENST00000426788:GtoV;

ENST00000311764:CtoF;

ENST00000294753:DtoN;ENST00000366498:DtoN;

ENST00000269829:YtoN;ENST00000415203:YtoN;
ENST00000269829:YtoH;ENST00000415203:YtoH;ENST00000441758:YtoH;

ENST00000396154:KtoE;
ENST00000396150:StoN;
ENST00000396150:StoG;ENST00000396154:KtoR;
ENST00000396150:LtoV;ENST00000396154:PtoR;
ENST00000296437:TtoI;ENST00000354698:TtoI;ENST00000412564:TtoI;ENST00000
ENST00000431526:GtoD;

ENST00000300850:GtoW;

ENST00000324048:ItoV;ENST00000336715:ItoV;ENST00000368879:ItoV;

ENST00000254321:CtoS;
ENST00000339411:GtoD;ENST00000373953:GtoD;ENST00000417184:GtoD;ENST00

146

+
+
+
+
+
+

+
+
+
+
+

+
+

+
+
+
+

+
+
+
+

+
+
+
+
+
+
+

+
+
+
+
+

+
+
+
+
+
+
+

+
+
+
+

+
+
+

+
+
+

TtoG
AtoG
GtoT
AtoG
AtoC
CtoA
AtoG
AtoG
TtoC
AtoG
GtoA
AtoC
TtoC
CtoT
TtoC
AtoG
AtoC
CtoG
TtoG
TtoG
CtoA
TtoG
TtoC
AtoG
TtoC
GtoT
TtoC
CtoG
AtoG
AtoC
AtoG
AtoC
TtoC
CtoA
TtoA
AtoG
AtoC
TtoG
TtoC
TtoC
AtoC
TtoG
AtoG
TtoC
TtoC
TtoG
AtoG
AtoG
GtoT
CtoT
GtoC
TtoC
AtoT
TtoG
CtoA
GtoA
CtoA
GtoT
GtoT
TtoA
GtoT
TtoG
GtoA
AtoT
AtoC
GtoA
TtoC
AtoG
TtoA
TtoC
GtoA
AtoG
AtoG
TtoC
TtoC
AtoG
GtoA
AtoG
CtoG
CtoT
AtoG
GtoA
TtoC
TtoA
TtoA
GtoA
GtoT
AtoC
AtoG
TtoC
AtoG
TtoA
AtoG
GtoC
GtoA
TtoA

0.1538
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.2
0.1
0.1818
0.1
0.1333
0.1
0.1
0.1
0.1
0.1
0.125
0.1818
0.1
0.1
0.1
0.1053
0.1
0.1
0.1
0.1
0.1154
0.125
0.1
0.1
0.1
0.1
0.1
0.1111
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1
0.1
0.2
0.1111
0.1
0.1111
0.1
0.1154
0.1481
0.1
0.1
0.1
0.1
0.1
0.1176
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1818
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1852
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1282
0.1
0.1
0.1
0.1
0.1
0.1

0.2
0.1111
0.1
0.1818
0.1
0.1
0.25
0.1818
0.125
0.1538
0.1
0.3333
0.1
0.3333
0.1875
0.1333
0.1053
0.1053
0.1
0.25
0.1
0.2
0.3
0.1
0.1
0.1
0.1333
0.2
0.125
0.1
0.1
0.1333
0.1818
0.1
0.1
0.1818
0.1
0.1333
0.2
0.1538
0.2
0.1
0.1
0.1
0.125
0.1
0.2
0.1
0.1
0.375
0.3
0.1
0.125
0.1053
0.2069
0.25
0.2778
0.1176
0.1538
0.125
0.1
0.1667
0.1
0.2
0.1333
0.1
0.125
0.2308
0.1818
0.1
0.1
0.1818
0.1
0.1667
0.1538
0.2
0.2
0.2143
0.1667
0.4545
0.1538
0.1905
0.1538
0.1429
0.1818
0.1111
0.1
0.1
0.1
0.24
0.1
0.1667
0.1818
0.1538
0.1
0.1

2
2
3
2
2
2
5
2
2
2
2
4
2
4
2
2
2
3
3
3
2
3
5
2
2
2
3
4
2
3
2
2
5
2
2
2
2
3
5
3
4
3
2
2
5
3
2
2
2
5
3
2
3
3
6
5
4
2
3
4
2
8
3
2
2
3
7
7
2
3
2
8
2
3
2
2
3
4
3
8
2
2
10
3
3
5
2
4
3
9
2
3
6
2
2
2

2
2
2
2
2
2
2
2
2
2
2
3
2
3
2
2
2
2
2
3
2
2
2
2
2
2
2
4
2
2
2
2
3
2
2
2
2
2
2
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
3
3
3
2
2
2
2
2
2
2
2
2
4
4
2
2
2
2
2
2
2
2
3
4
2
3
2
2
3
2
2
3
2
2
2
3
2
2
3
2
2
2

[10,13]
[10,18]
[10,10]
[10,11]
[10,10]
[10,10]
[10,12]
[10,12]
[10,17]
[10,13]
[10,10]
[10,12]
[10,10]
[10,24]
[10,16]
[15,15]
[10,19]
[10,19]
[10,10]
[10,14]
[10,10]
[10,16]
[10,11]
[10,10]
[10,10]
[10,10]
[15,19]
[10,10]
[10,16]
[10,10]
[10,10]
[16,27]
[11,16]
[10,10]
[10,10]
[10,11]
[10,10]
[10,15]
[10,18]
[10,15]
[10,17]
[10,10]
[10,10]
[10,10]
[16,17]
[20,70]
[10,10]
[10,10]
[10,10]
[10,16]
[11,27]
[10,10]
[10,17]
[10,19]
[23,29]
[11,27]
[18,20]
[10,17]
[10,13]
[11,16]
[10,10]
[17,20]
[10,10]
[10,10]
[10,15]
[10,10]
[10,20]
[10,25]
[11,11]
[10,10]
[10,10]
[11,11]
[10,10]
[10,12]
[10,13]
[10,10]
[10,15]
[10,14]
[10,12]
[10,11]
[10,13]
[21,27]
[10,13]
[10,14]
[10,11]
[10,18]
[10,10]
[10,10]
[10,10]
[25,41]
[10,10]
[10,13]
[10,11]
[10,13]
[10,10]
[10,10]

TableS10

chr7:149726569
chr7:148764694
chr19:45279616
chr7:148594886
chr7:148594881
chr7:148612383
chr16:30504056
chr7:98929859
chr7:98930031
chr19:58147881
chr19:58147854
chr19:58147853
chr4:146902053
chr17:30313808
chr14:101871819
chr20:47297337
chr20:47320856
chr20:47296589
chr7:100648182
chr17:31916665
chr17:31922792
chr17:31925556
chr10:126660276
chr10:126652861
chr10:126664498
chr1:71310809
chr1:71302642
chr1:71303151
chr15:41438514
chr17:15822112
chr15:64612378
chr15:64627743
chr10:57787465
chr10:57787551
chr3:127663592
chr1:53131485
chr17:3904101
chr17:3908117
chr1:77814393

ZNF775
ZNF777
ZNF780A
ZNF783
ZNF783
ZNF783
ZNF785
ZNF789
ZNF789
ZNF816A
ZNF816A
ZNF816A
ZNF827
ZNF830
ZNF839
ZNFX1
ZNFX1
ZNFX1
ZNHIT1
ZNHIT3
ZNHIT3
ZNHIT3
ZRANB1
ZRANB1
ZRANB1
ZRANB2
ZRANB2
ZRANB2
ZSCAN29
ZSWIM7
ZWILCH
ZWILCH
ZWINT
ZWINT
ZXDC
ZYG11A
ZZEF1
ZZEF1
ZZZ3

UTR3
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
coding_exon
UTR3
coding_exon
mixed
coding_exon
coding_exon
mixed
UTR5
coding_exon
coding_exon
UTR3
coding_exon
coding_exon
UTR3
coding_exon
UTR3
UTR3
UTR3
coding_exon
coding_exon
UTR3
UTR3
UTR3
coding_exon
UTR3
coding_exon
coding_exon
coding_exon

ENST00000247930:MtoR;ENST00000314683:MtoR;ENST00000440594:MtoR;
ENST00000340963:EtoG;ENST00000392041:EtoG;ENST00000414720:EtoG;ENST000
ENST00000434415:LtoQ;

ENST00000321694:KtoN;ENST00000395216:KtoN;ENST00000395222:KtoN;ENST00

ENST00000357666:NtoI;ENST00000444460:NtoI;
ENST00000357666:AtoD;ENST00000444460:AtoD;

ENST00000359653:TtoR;
ENST00000359653:LtoQ;

ENST00000336332:StoP;ENST00000389709:StoP;ENST00000435595:StoP;

ENST00000370798:DtoA;ENST00000370801:DtoA;ENST00000420374:DtoA;

147

+
+
+

+
+

+
+

+
+
+
+
+
+
+

+
+

TtoG
TtoG
AtoG
TtoA
TtoC
AtoG
AtoT
CtoT
CtoT
AtoT
CtoA
TtoC
CtoA
AtoG
TtoC
TtoC
TtoA
TtoC
AtoT
GtoT
TtoC
AtoG
CtoG
TtoA
AtoG
TtoC
TtoC
AtoG
AtoG
TtoC
TtoC
CtoG
TtoA
GtoC
TtoC
TtoG
AtoG
CtoA
AtoC

0.1667
0.1
0.1
0.1818
0.1667
0.1
0.1
0.6667
0.1
0.1111
0.1
0.1
0.1
0.1333
0.1
0.1111
0.1
0.1
0.1818
0.1081
0.1111
0.1071
0.1
0.1
0.1
0.1
0.1
0.2
0.1
0.1
0.2
0.1
0.1034
0.1429
0.1
0.1
0.1
0.1
0.1

0.1667
0.1
0.1111
0.5
0.3077
0.1
0.1
0.6818
0.1
0.1818
0.1
0.5455
0.1
0.2
0.4
0.1538
0.1
0.1111
0.2
0.1333
0.1304
0.1212
0.1
0.1
0.1
0.1429
0.1
0.2857
0.1429
0.1
0.3
0.125
0.1429
0.3333
0.125
0.1
0.1
0.1
0.1

4
2
3
5
3
3
2
2
2
2
4
4
2
2
2
4
3
5
3
3
9
9
2
2
3
5
4
3
3
2
2
2
6
6
4
3
2
2
2

2
2
2
5
3
2
2
2
2
2
2
4
2
2
2
2
2
3
2
2
3
2
2
2
2
2
2
2
2
2
2
2
4
5
3
2
2
2
2

[12,12]
[10,10]
[10,10]
[10,13]
[12,14]
[10,11]
[10,10]
[15,22]
[10,10]
[11,18]
[10,10]
[10,13]
[10,10]
[10,15]
[10,10]
[13,27]
[10,10]
[10,18]
[10,11]
[15,37]
[17,23]
[28,34]
[10,10]
[10,10]
[10,10]
[14,20]
[10,20]
[10,14]
[10,14]
[10,10]
[10,10]
[10,16]
[19,34]
[32,46]
[10,17]
[10,10]
[10,10]
[10,10]
[10,10]

REFERENCES
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
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18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44.

R.T.Libby,J.A.Gallant,MolMicrobiol5,999(1991).
J.F.Sydow,P.Cramer,CurrOpinStructBiol19,732(2009).
S.H.Chenetal.,Science238,363(1987).
L.M.Powelletal.,Cell50,831(1987).
B.L.Bass,H.Weintraub,Cell55,1089(1988).
J.B.Lietal.,Science324,1210(2009).
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