sfEdlman\TiBlelIRbBnsrsR bsaTsVyt

(Autonomic Nervous System Agents)

rYmman
sfEdlman\TiBlelIRbB&ns rsRbsaT Sympathetic:
1. Adrenergics or Sympathomimetics or Adrenomimetics or Adrenergic Agonists 2. Adrenergic blockers or Adrenergic Antagonists or Sympatholytics or Adrenolytics

sfEdlman\TiBlelIRbB&nsr

sRbsaTParasympathetic:

1. Cholinergics or Parasympathomimetics or Cholinergic Agonists 2. Anticholinergics or Parasympatholytics or Cholinergic Antagonist or Antispasmodics

Autonomic Nervous System Agents

I. Review of Nervous System

RbB&nsrsRbsaT (Nervous System) EbgEckCaRbB&nsrsRbsaTkNal (CNS) nigsrsRbsaTxageRkA (PNS). CNS manxYrk,al nig xYrqwgxg (Brain and Spinal cord). cMEnk PNS EbgEckCaBIrEpkKW Autonomic Nervous - System (ANS)nig Somatic Nervous System (SNS). vaman NeuronsBIr RbePTenAkg PNS KW Sensory Neurons EdldwknaMBtman (action potentials) BIGkTTYl(Sensory Receptors)eTARbBnssRbsaTkNal nig

Motor Neurons Edldwk

naMBtman BI CNS eTAsriragRbtibti (Effector Organs) dUcCasac;dMurlIg nigRkeBj. Motor Neurons enHdwknaMBtmantam pvBIrRbePTKWmYyrytam Autonomic
Nervous System

CaRbB&nsrsRbsaTEdleyIgminGacb Baa)anrYmman sac;dMuebH dUg sac;dMurlIg nig RkeBj (cardiac muscle, smooth muscles and glands) ehIymYyeTottamry Somatic Nervous System CaRbB&nsrsRbsaTEdleyIgGacRKb;RKg rWbBaa)andUcCa sac;dMuCab;qwg (Skeletal muscles).
Autonomic Nervous SystemEbgEckCaBIrRbePTeTotKW Sympathetic

nig Parasympathetic Nervous System EdlRbB&nsrsRbsaTTaMgBIrenHvae FIV-

karpyKaedI ,I[ragkaymnusSeyIgm antulPaB (Homeost sis) .

II.

karEbgEckRbBnsrsRbsaT
Nervous System

(Subdi isions of t e nervous system):

Central Nervous System

Brain Spinal Cord

eri eral Nervous System ( NS)

Autonomi Nervous System Somati Nervous System

Sympat eti Nervous System

arasympat eti Nervous System

III. \TiBlRbBn Sympathetic nig Parasympathetic

m elIsrIrag (Sympathetic and Parasympathetic effects on

body tissues): Body tissues/organ Eye: Sympathetic Response Dilates pupils Dilates bronchioles Increases Heart rate Constricts Blood vessels Parasympathetic Response Constricts pupils Constricts and Increases secretions Decreases Heart rate Dilates Blood vessels Increases peristalsis

EPk

Lungs: sYt Heart:

ebHdUg
Blood vessels:

srsQam
Gastrointestinal Relaxes smooth muscles : gastrointestinal tract

RkBHeBaH evon
Bladder: Relaxes Bladder muscles Relaxes uterine muscles Increases salivation Constricts

e)akenam
Uterus:

s,n

Salivary gland:

RkeBjTwk mat;
Note: The Sympathetic and Parasympathetic Nervous Systems have opposite responses on body tissues and organs.

IV. Classifications of Autonomic Nervous System Agents:

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1. Autonomic Nervous System Stimulants: -Sympathetic Stimulants -Parasympathetic Stimulants. 2. Autonomic Nervous System Depressants: -Sympathetic Depressants -Parasympathetic Depressants.

A. Sympathetic Stimulants:
 Sympathomimetics or Adrenergics or Adrenomimetics or Adrenergic agonist drugs

manskmPaB -Increase blood pressure: begInsm<aFQam

-Increase pulse rate: begIncgVak;CIBcr

-Increase blood sugar: begInCatisrkgQam

-Relax bronchioles: TgsYtrIk -Relax uterine muscles: sac;duMs,nsRmak -Dilate pupils of the eyes: RbRsIEPkrIk B. Parasympathetic Stimulants: Direct acting RkumsfmanskmPaBpal;

Parasympathomimetics or cholinergics or cholinergic

agonists

manskmPaB
-Decrease pulse rate:

-Decrease blood pressure: - Constricts bronchioles: - Constricts pupils of the eyes:

-Increase urinary contraction: -Increase peristalsis:

Indirect acting

RkumsfmanskmPaBminpal; Rbeyal
 Cholinesterase Inhibitors or Anticholinesterase

manskmPaB
-Increase muscle tone.
C. Sympathetic Depressants:  Sympatholytics or Adrenergic Blockers or Adrenolytics or Adrenergic Antagonists

manskmPaB
-Decrease pulse rate: -Decrease blood pressure: -Constrict bronchioles:

D. Parasympathetic Depressants:  Parasympatholytics or Anticholinergics or Cholinergic Antagonists or Antispasmodics

manskmPaB
-Increase pulse rate:

-Increase urinary retention:

-Decrease gastrointestinal motility: -Decrease mucous secretion: -Dilate pupils of the eyes:

Note: Sympathetic and Parasympathetic Responses to Drugs Sympathetic

Sympathomimetic Sympatholytic Sympathomimetic Sympatholytic

Parasympathetic
Parasympathomimetic Parasympatholytic Parasympatholytic Parasympathomimetic

Response
Opposite Response Opposite Response Similar Response Similar Response