Brand Name: Ponstan Generic Name: Mefenamic Acid Indications: Mild to moderate pain in rheumatic disease and other

musculo-skeletal disorders, reduce high body temperature, lessen the pain of menstrual problems. Drug Classification: Anti-inflammatory, analgesic Mechanism of Action: It works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is an enzyme that is involved in the production of various chemicals in the body, some of which are known as prostaglandins. Prostaglandins are produced in response to injury or certain diseases and cause pain, swelling and inflammation. As mefenamic acid stops the production of prostaglandins, it is effective at relieving pain and inflammation. Mefenamic acid may also works by preventing the action of prostaglandins after they have already been formed. Dosage: initially 500 mg, followed by 250 mg q 6 hrs prn. Special Precautions: Patients with any allergic condition (including asthma). Pregnancy Risk Category: B

Adverse Reactions: GI: Nausea, GIT disturbances may eventually result in ulceration, CNS: drowsiness, dizziness Contraindications: Patients with inflammations in the intestines, peptic ulcers, or impaired liver or kidney function, or who are pregnant. Forms: Capsules 250mg, 500 mg; tablets; soluble tablets; childrens suspension for dilution; Nursing Responsibilities:  Administer with meals, food, or milk to minimize GI adverse effects.  Diabetic patients may show increased need for insulin.  Children under 12 years of age should be prescribed mefenamic acid liquid, rather than tablets or capsules, as this allows a more accurate dose to be given.  Advise client to notify physician if persistent GI discomfort, sore throat, fever, or malaise occur.