IMMUNOLOGY

TODAY

Expanding the role of Peyers patches in B-cell ontogeny

Philip J. Griebel and Wayne R. Hein

IMMUNOLOGY

TODAY

Box I. What did Poysr actually say about hi patshal

IMMUNOLOGY

TODAY

Year 1677

PfUpXIl Mucus-secreting glands Lymphoid tissue connected lymphatlcs to Siies of iymphxyte dlwslon similar to germinalcenters

PA

t
2 3

1851
,885 I928

Jejunal and ileal P&s

patcha have

distinct developmental p8ftems 1960s Se ofrntigen smpling (M cells) and specificinduction of ,m~co~al imnlunrly (,.e. I&A) I9Ear siteofgeneratlov dsyaemic pre-im~ne immunoglobulinrepertoire 12-16 s. 9-l I

These same grwpb ~150 define two distinct patterns of PI development. In Group animals,4% develop in the ikum and jejunum prena4at*yl.?,.~~.~,, As noted earlier, the two types of PP have d different life history after birth. The ileal PR reach their maximum early in tiff and then mmmen~e ~tze involution in a way similar to the

thymus. F~orexample, in sheep, the total mass of &al PI tissue is Tab& 2. An interrpeckr No. -ileum compar4ron of tbc diwibution and damfopmcmt of PFs Prenat?l development

of PR

in;

jeiunum

No. of follicles in: ltern ieiunum

lleal PPS(?q

Refs

Single (I

J-20 m)
m)

25-40

ICQCCQ

IOCCQ

90

4. I2

Single

(I.o-2.0

t4-27

78 ooo

9col

90

4, 17, I8

Single (0.2-0.3 m) Sewra (0.1-0.3 m) HLIIITW trrwp P&&ii Rat Mause II SKRdU5 rotundus 18-10 6-17 several

26-29

ND

ND

00

19,2a

245-320

ND

ND

lIea PP5 larger

180-240

IOOW-2ocCo

tIeal PPS larger

21

I-10

ND NO l-57 ND

ND

ND No bias No btas

22 23,24 25 ___ 26

ChKkcn Single several -Abbrwiationc: ND, m dataqwted; PP. PeyerspltEhea

ND

ND

JANUARY

1996

Lik history

structure

Cdllwcclnpmitio
of fo!licks

IMMUNOLOGY

TODAY

IMMUNOLOGY

TODAY

IMMUNOLOGY

TODAY

IMMUNOLOGY

TODAY

IMMUNOLOGY

TODAY

Preventing abnormalities in signal transduction of T cells in cancer: the promise of cytokine gene therapy

JANUARY

1996