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Opportunistic Amoeba Facultative Parasites
Opportunistic Amoeba Facultative Parasites
Opportunistic Amoeba Facultative Parasites
AMOEBA
FACULTATIVE
PARASITES
• Naegleria is an amoeba commonly found in warm freshwater and
soil. Only one species of Naegleria infects people, Naegleria
fowleri. It causes a very rare but severe brain infection. Most
infections are fatal.
• Soil
• Hold the nose shut or use nose clips when taking part in water-related
activities in bodies of warm freshwater such as lakes, rivers, or hot
springs.
• Entry can occur through the eye, the nasal passages to the lower respiratory
tract , or ulcerated or broken skin.
• When Acanthamoeba spp. enters the eye it can cause severe keratitis in
otherwise healthy individuals, particularly contact lens users.
• When it enters the respiratory system or through the skin, it can invade the
central nervous system by hematogenous dissemination causing
granulomatous amebic encephalitis (GAE) or disseminated disease, or skin
lesions in individuals with compromised immune systems.
– Eye pain
– Eye redness
– Blurred vision
– Sensitivity to light
– Sensation of something in the eye
– Excessive tearing
• Eye infection with Acanthamoeba has never been known to cause infections in other
parts of the body.
• Acanthamoeba can also cause skin lesions and/or disseminated infection. These
infections usually occur in people with compromised immune systems. Acanthamoeba
can cause a serious, most often deadly, infection of the brain and spinal cord called
Granulomatous Amebic Encephalitis (GAE). Once infected, a person may suffer with
headaches, stiff neck, nausea and vomiting, tiredness, confusion, lack of attention to
people and surroundings, loss of balance and bodily control, seizures, and
hallucinations. Symptoms progress over several weeks and death usually occurs. Skin
infections do not necessarily lead to disseminated disease.
Prevention
• Even though acanthamoeba keratitis is much more common than it used to
be, it is still rare even among contact lens wearers. To avoid this devastating
infection:
– Never allow lenses or cases to come in contact with tap water.
– Never swim with contact lenses in, even in a chlorinated swimming
pool.
– Don’t shower with contact lenses in your eyes.
– Never wear contact lenses when your eyes are irritated or if you suspect
you have even a tiny scratch.
– Do not keep lenses or solutions past their expiry date.
– Do not wear lenses for longer periods than your eye professional
recommends.
– Always carefully follow your eye professional’s instructions for
cleaning contact lenses.
– A lens cleaning routine that requires rubbing is preferable to one that
only requires soaking.
• Contact lenses and lens care disinfectants are improving; however, contact
lens wearers still have to be careful. Taking the precautions listed above
should keep this opportunistic amoeba where it belongs—in the
environment.
Where is Acanthamoeba found?
• Acanthamoeba is found worldwide. Most
commonly, Acanthamoeba is found in the soil and
dust, in fresh water sources such as lakes, rivers,
and hot springs, in brackish water, and in sea
water. Acanthamoeba can also be found in
swimming pools, hot tubs, in drinking water
systems (e.g., slime layers in pipes, taps), as well
as heating, ventilating, and air conditioning
(HVAC) systems and humidifiers.
Acanthamoeba
Summary
Acanthamoeba
• Most common species: Acanthamoeba culbertsoni
• Found in soil or stagnant waters
Source of infection: dust or water
Resistant to chlorine and drying
• Life cycle
a) Trophozoite - no flagellate form
b) Cyst
• Pathogenesis
Portal of Entry: broken or ulcerated skin/eyes
lungs and GIT
• Disease:
Chronic Meningoencephalitis in immunocompromised host
Corneal ulceration
• Treatment: Sulfadiazine
• Prevention: early diagnosis
prompt treatment of lesions
Free-Living Amoebas
Submitted To:
Dr. Celino
Prepared By:
Elizabeth G. Querubin
Mon Aldrin E. Evangelista
Tricia A. Narido
BSN 2-B
Tuesday 4:30-7:30