Cholestasis

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Neonatal Cholestasis

Prolonged elevation of serum levels of conjugated bilirubin beyond the 1st 14 days of life that appears after 2 wk of age, progresses after this time, or does not resolve at this time should be evaluated and a conjugated bilirubin level determined

Jaundice

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 Cholestasis

in a newborn:

infectious Genetic Metabolic undefined

mechanical obstruction of bile flow functional impairment of hepatic excretory function and bile secretion

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(see Table 352-3 ). Mechanical lesions include stricture or obstruction of the common bile duct; biliary atresia is the prototypic obstructive abnormality. Functional impairment of bile secretion can result from congenital defects or damage to liver cells or to the biliary secretory apparatus. Neonatal cholestasis can be divided into extrahepatic and intrahepatic disease ( Fig. 353-1 ). The clinical features of any form of cholestasis are similar. In an affected neonate, the diagnosis of 4/15/12

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