CERTIFICATE

This is to certify that the work presented in the thesis entitled DEVELOPMENT AND VALIDATION OF UV-VISIBLE METHODS SPETROPHOTOMETRIC, HPTLC, AND RP-HPLC

FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE , HYDROCHLORTHIAZIDE AND VALSARTAN IN THEIR COMBINED DOSAGE FORM by Mr. MANISH B. SHARMA. In the partial fulfillment for the requirement of degree of Master of Pharmacy, is carried out under my guidance and to my satisfaction. I recommended this project report ready for examination. This work is carried out by him and has not been submitted earlier either to this university or to any other institutions for fulfillment of requirement of a course of study. Guided By: Dr. CHARMY S. KOTHARI M.PHARM, PH.D DEPARTMENT OF PHARMCEUTCIAL ANALYSIS INSTITUTE OF PHARMACY Nirma University o

Forwarded Through: Dr. PRITI J.MEHTA HEAD, DEPARTMENT OF PHARMCEUTCIAL ANALYSIS Institute of Pharmacy, Nirma University

DECLARATI ON
I, MANISH B. SHARMA, Final Year M. Pharm student of the Institute of Pharmacy, Nirma University, hereby state that the study entitled DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROPHOTOMETRIC, HPTLC AND RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE, HYDROCHLORTHIAZIDE AND VALSARTAN IN COMBINED DOSAGE FORM is my own work and that, to the best of my knowledge, it contains no material previously published or written by another person nor material which to a substantial extent has been accepted for the award of any other degree or Diploma of University or other institute, except where due acknowledgement has been made in this text. I also here by give my unconditional undertaking that all the rights to use this work, for publication of any kind scientific or commercial purpose, completely rest with my guide.

Date:

MANISH B. SHARMA

Dedicated to My Family and Friends