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    The document summarizes key information about hepatitis E virus (HEV) including that the average incubation period is 40 days, pregnant women have the highest case-fatality rate at 15-25%, and most outbreaks are associated with fecally contaminated drinking water with minimal person-to-person transmission. It also provides recommendations for travelers to endemic areas to avoid untreated water and certain raw foods to prevent infection.

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    The document summarizes key information about hepatitis E virus (HEV) including that the average incubation period is 40 days, pregnant women have the highest case-fatality rate at 15-25%, and most outbreaks are associated with fecally contaminated drinking water with minimal person-to-person transmission. It also provides recommendations for travelers to endemic areas to avoid untreated water and certain raw foods to prevent infection.

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    27 views6 pages

    Epatite E

    Uploaded by

    api-3704348
    The document summarizes key information about hepatitis E virus (HEV) including that the average incubation period is 40 days, pregnant women have the highest case-fatality rate at 15-25%, and most outbreaks are associated with fecally contaminated drinking water with minimal person-to-person transmission. It also provides recommendations for travelers to endemic areas to avoid untreated water and certain raw foods to prevent infection.

    Copyright:

    Attribution Non-Commercial (BY-NC)
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    of 6

    Hepatitis E Virus

    Hepatitis E - Clinical Features

    • Incubation period: Average 40 days


    Range 15-60 days
    • Case-fatality rate: Overall, 1%-3%
    Pregnant women, 15%-25%
    • Illness severity: Increased with age
    • Chronic sequelae: None identified
    Hepatitis E Virus Infection
    Typical Serologic Course
    Symptoms

    ALT
    IgG anti-HEV

    IgM anti-HEV
    Titer

    Virus in stool

    0 1 2 3 4 5 6 7 8 9 10 11 12 13

    Weeks after Exposure


    Hepatitis E -
    Epidemiologic Features

    • Most outbreaks associated with


    fecally contaminated drinking water
    • Minimal person-to-person transmission
    • U.S. cases usually have history of travel
    to HEV-endemic areas
    Geographic Distribution of Hepatitis E
    Outbreaks
    Outbreaks or
    or Confirmed
    Confirmed Infection
    Infection in
    in >25%
    >25% of
    of Sporadic
    Sporadic Non-ABC
    Non-ABC Hepatitis
    Hepatitis
    Prevention and Control Measures for
    Travelers to HEV-Endemic Regions
    • Avoid drinking water (and beverages with ice) of unknown
    purity, uncooked shellfish, and uncooked fruit/vegetables
    not peeled or prepared by traveler
    • IG prepared from donors in Western countries does not
    prevent infection
    • Unknown efficacy of IG prepared from donors in endemic
    areas
    • Vaccine?

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