CeII SignaIing CeII SignaIing

TEAM MEMBERS
Soumya
Subeesh
Shakily
Treesa Jojo Kodiyan
Veena Mathew
Vineeth
SignaIing Events
Recognition of stimuIus
Transmission of signaI
Triggering a response
SIGNALS
TYPES OF CELL SIGNALING
!#TENS/#ECE!T#S N #
N THE CELL SU#CE
#ECEVE SGNLS
NT#CELLUL# #ECE!T#S
Signals from lipid soluble, non charged,
non polar small molecule
Signals pass across plasma membrane of
target cell
#eceptors on cytoplasm ,nucleus
Slower long lasting
RECEPTORS ACT AS GENE
REGULATORS
#eceptors for
cortisol,estrogen,projestron,vit D,tyroid
hormone
inding of a steroid hormone to a
DN regulatory protein
lter shape and inhibitor releaced
DN binding site exposed
DN binds to site and transcription
follows
RECEPTORS ACT AS ENZYMES
#eceptor for N binds with GUNYLYL
CYCLSE
ctivates enzyme
Synthesis of GM!
#elaxation of smooth muscle
EXTRA CELLULAR
RECCEPTORS
SignaIs are water soIuabIe
CeII responds quickIy
They are short Iived
Receptors beIong to.
Chemically gated channels
Enzymic receptors
G-protein linked receptors