pepLlc ulcer dlsease lnfecLlon lngesLlon of nSAlus or smoklng ls essenLlal ln maklng Lhe correcL dlagnosls W plgasLrlc paln ls Lhe mosL common sympLom of boLh gasLrlc and duodenal ulcers lL ls characLerlzed by a gnawlng or burnlng sensaLlon and occurs afLer mealsclasslcally shorLly afLer meals wlLh gasLrlc ulcer and 23 hours afLerward wlLh duodenal ulcer W ood or anLaclds relleve Lhe paln of duodenal ulcers buL provlde mlnlmal rellef of gasLrlc ulcer paln W aLlenLs who develop gasLrlc ouLleL obsLrucLlon as a resulL of a chronlc unLreaLed duodenal ulcer usually reporL a hlsLory of fullness and bloaLlng assoclaLed wlLh nausea and emesls LhaL occurs several hours afLer food lnLake W CLher posslble manlfesLaLlons lnclude Lhe followlng uyspepsla lncludlng belchlng bloaLlng dlsLenLlon and faLLy food lnLolerance PearLburn ChesL dlscomforL PemaLemesls or melena resulLlng from gasLrolnLesLlnal bleedlng Melena may be lnLermlLLenL over several days or mulLlple eplsodes ln a slngle day 8arely a brlskly bleedlng ulcer can presenL as hemaLochezla SympLoms conslsLenL wlLh anemla (eg faLlgue dyspnea) may be presenL Sudden onseL of sympLoms may lndlcaLe perforaLlon W Alarm feaLures LhaL warranL prompL gasLroenLerology referral lncluded 8leedlng or anemla arly saLleLy unexplalned welghL loss rogresslve dysphagla or odynophagla 8ecurrenL vomlLlng amlly hlsLory of Cl cancer